| Year |
Citation |
Score |
| 2018 |
Easton V, McPhillie M, Garcia-Dorival I, Barr J, Edwards T, Foster R, Fishwick C, Harris M. Identification of a small molecule inhibitor of Ebolavirus genome replication and transcription using in silico screening. Antiviral Research. PMID 29870771 DOI: 10.1016/J.Antiviral.2018.06.003 |
0.36 |
|
| 2018 |
Johnson R, Amporndanai K, Fishwick C, Hasnain S, Antonyuk S, Muench S. EM studies of cytochrome bc
1 to elucidate inhibitor binding Acta Crystallographica Section a Foundations and Advances. 74: a121-a121. DOI: 10.1107/S0108767318098781 |
0.35 |
|
| 2017 |
Johnson R, Rawson S, McPhillie M, Fishwick C, Muench S. The Growing Role of Electron Microscopy in Anti-parasitic Drug Discovery. Current Medicinal Chemistry. PMID 29119913 DOI: 10.2174/0929867324666171109120526 |
0.318 |
|
| 2016 |
Gordon JA, Fishwick CW, McPhillie MJ. New Opportunities in the Structure-based Design of Anti-Protozoan Agents. Current Topics in Medicinal Chemistry. PMID 27531028 DOI: 10.2174/1568026616666160719164542 |
0.386 |
|
| 2016 |
Brem J, Cain R, Cahill S, McDonough MA, Clifton IJ, Jiménez-Castellanos JC, Avison MB, Spencer J, Fishwick CW, Schofield CJ. Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates. Nature Communications. 7: 12406. PMID 27499424 DOI: 10.1038/Ncomms12406 |
0.32 |
|
| 2016 |
McPhillie M, Zhou Y, El Bissati K, Dubey J, Lorenzi H, Capper M, Lukens AK, Hickman M, Muench S, Verma SK, Weber CR, Wheeler K, Gordon J, Sanders J, Moulton H, ... ... Fishwick C, et al. New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections. Scientific Reports. 6: 29179. PMID 27412848 DOI: 10.1038/Srep29179 |
0.315 |
|
| 2015 |
Shaw J, Harris M, Fishwick CW. Identification of a lead like inhibitor of the hepatitis C virus non-structural NS2 autoprotease. Antiviral Research. PMID 26518228 DOI: 10.1016/J.Antiviral.2015.10.001 |
0.362 |
|
| 2015 |
King R, Tiede C, Simmons K, Fishwick C, Tomlinson D, Ajjan R. Inhibition of complement C3 and fibrinogen interaction: a potential novel therapeutic target to reduce cardiovascular disease in diabetes. Lancet (London, England). 385: S57. PMID 26312879 DOI: 10.1016/S0140-6736(15)60372-5 |
0.656 |
|
| 2015 |
Latham AM, Kankanala J, Fishwick CW, Ponnambalam S. Identification of Receptor Tyrosine Kinase Inhibitors Using Cell Surface Biotinylation and Affinity Isolation. Methods in Molecular Biology (Clifton, N.J.). 1332: 121-31. PMID 26285749 DOI: 10.1007/978-1-4939-2917-7_8 |
0.342 |
|
| 2015 |
Caseley EA, Muench SP, Baldwin SA, Simmons K, Fishwick CW, Jiang LH. Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human. Bioorganic & Medicinal Chemistry Letters. PMID 26099538 DOI: 10.1016/J.Bmcl.2015.06.001 |
0.681 |
|
| 2015 |
Avery CA, Pease RJ, Smith K, Boothby M, Buckley HM, Grant PJ, Fishwick CW. (±) cis-bisamido epoxides: A novel series of potent FXIII-A inhibitors. European Journal of Medicinal Chemistry. 98: 49-53. PMID 26005023 DOI: 10.1016/J.Ejmech.2015.05.019 |
0.335 |
|
| 2015 |
Kime L, Vincent HA, Gendoo DM, Jourdan SS, Fishwick CW, Callaghan AJ, McDowall KJ. The first small-molecule inhibitors of members of the ribonuclease E family. Scientific Reports. 5: 8028. PMID 25619596 DOI: 10.1038/Srep08028 |
0.363 |
|
| 2015 |
McPhillie MJ, Cain RM, Narramore S, Fishwick CW, Simmons KJ. Computational methods to identify new antibacterial targets. Chemical Biology & Drug Design. 85: 22-9. PMID 24974974 DOI: 10.1111/Cbdd.12385 |
0.697 |
|
| 2014 |
Latham AM, Kankanala J, Fearnley GW, Gage MC, Kearney MT, Homer-Vanniasinkam S, Wheatcroft SB, Fishwick CW, Ponnambalam S. In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis. Plos One. 9: e110997. PMID 25393739 DOI: 10.1371/Journal.Pone.0110997 |
0.355 |
|
| 2014 |
Yule IA, Czaplewski LG, Pommier S, Davies DT, Narramore SK, Fishwick CW. Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: structure based design, synthesis, SAR and antimicrobial activity. European Journal of Medicinal Chemistry. 86: 31-8. PMID 25137573 DOI: 10.1016/J.Ejmech.2014.08.025 |
0.41 |
|
| 2014 |
Cain R, Narramore S, McPhillie M, Simmons K, Fishwick CW. Applications of structure-based design to antibacterial drug discovery. Bioorganic Chemistry. 55: 69-76. PMID 24962384 DOI: 10.1016/J.Bioorg.2014.05.008 |
0.696 |
|
| 2014 |
Simmons KJ, Jackson SM, Brueckner F, Patching SG, Beckstein O, Ivanova E, Geng T, Weyand S, Drew D, Lanigan J, Sharples DJ, Sansom MS, Iwata S, Fishwick CW, Johnson AP, et al. Molecular mechanism of ligand recognition by membrane transport protein, Mhp1. The Embo Journal. 33: 1831-44. PMID 24952894 DOI: 10.15252/Embj.201387557 |
0.689 |
|
| 2014 |
Lolicato M, Bucchi A, Arrigoni C, Zucca S, Nardini M, Schroeder I, Simmons K, Aquila M, DiFrancesco D, Bolognesi M, Schwede F, Kashin D, Fishwick CW, Johnson AP, Thiel G, et al. Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness. Nature Chemical Biology. 10: 457-62. PMID 24776929 DOI: 10.1038/Nchembio.1521 |
0.685 |
|
| 2014 |
Ravichandran S, Singh N, Donnelly D, Migliore M, Johnson P, Fishwick C, Luke BT, Martin B, Maudsley S, Fugmann SD, Moaddel R. Pharmacophore model of the quercetin binding site of the SIRT6 protein. Journal of Molecular Graphics & Modelling. 49: 38-46. PMID 24491483 DOI: 10.1016/J.Jmgm.2014.01.004 |
0.321 |
|
| 2014 |
Fisher M, Basak R, Kalverda AP, Fishwick CW, Turnbull WB, Nelson A. Discovery of novel FabF ligands inspired by platensimycin by integrating structure-based design with diversity-oriented synthetic accessibility. Organic & Biomolecular Chemistry. 12: 486-94. PMID 24276506 DOI: 10.1039/C3Ob41975D |
0.348 |
|
| 2014 |
Cunningham F, McPhillie MJ, Johnson AP, Fishwick CW. An in silico structure-based approach to anti-infective drug discovery. Parasitology. 141: 17-27. PMID 23768800 DOI: 10.1017/S0031182013000693 |
0.387 |
|
| 2013 |
Lloyd AJ, Potter NJ, Fishwick CW, Roper DI, Dowson CG. Adenosine tetraphosphoadenosine drives a continuous ATP-release assay for aminoacyl-tRNA synthetases and other adenylate-forming enzymes. Acs Chemical Biology. 8: 2157-63. PMID 23898887 DOI: 10.1021/Cb400248F |
0.324 |
|
| 2013 |
van Berkel SS, Brem J, Rydzik AM, Salimraj R, Cain R, Verma A, Owens RJ, Fishwick CW, Spencer J, Schofield CJ. Assay platform for clinically relevant metallo-β-lactamases. Journal of Medicinal Chemistry. 56: 6945-53. PMID 23898798 DOI: 10.1021/Jm400769B |
0.329 |
|
| 2013 |
Mok NY, Chadwick J, Kellett KA, Casas-Arce E, Hooper NM, Johnson AP, Fishwick CW. Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design. Journal of Medicinal Chemistry. 56: 1843-52. PMID 23374014 DOI: 10.1021/Jm301127X |
0.387 |
|
| 2013 |
Simmons KJ, Gotfryd K, Billesbølle CB, Loland CJ, Gether U, Fishwick CW, Johnson AP. A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT. Molecular Membrane Biology. 30: 184-94. PMID 22908980 DOI: 10.3109/09687688.2012.710341 |
0.697 |
|
| 2012 |
Bedingfield PT, Cowen D, Acklam P, Cunningham F, Parsons MR, McConkey GA, Fishwick CW, Johnson AP. Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases. Journal of Medicinal Chemistry. 55: 5841-50. PMID 22621375 DOI: 10.1021/Jm300157N |
0.415 |
|
| 2012 |
Wacker SJ, Jurkowski W, Simmons KJ, Fishwick CW, Johnson AP, Madge D, Lindahl E, Rolland JF, de Groot BL. Identification of selective inhibitors of the potassium channel Kv1.1-1.2((3)) by high-throughput virtual screening and automated patch clamp. Chemmedchem. 7: 1775-83. PMID 22473914 DOI: 10.1002/Cmdc.201100600 |
0.683 |
|
| 2012 |
Kankanala J, Latham AM, Johnson AP, Homer-Vanniasinkam S, Fishwick CW, Ponnambalam S. A combinatorial in silico and cellular approach to identify a new class of compounds that target VEGFR2 receptor tyrosine kinase activity and angiogenesis. British Journal of Pharmacology. 166: 737-48. PMID 22141913 DOI: 10.1111/J.1476-5381.2011.01801.X |
0.325 |
|
| 2012 |
Majeed Y, Tumova S, Green BL, Seymour VA, Woods DM, Agarwal AK, Naylor J, Jiang S, Picton HM, Porter KE, O'Regan DJ, Muraki K, Fishwick CW, Beech DJ. Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone. Cell Calcium. 51: 1-11. PMID 22000496 DOI: 10.1016/J.Ceca.2011.09.005 |
0.336 |
|
| 2011 |
Woon EC, Zervosen A, Sauvage E, Simmons KJ, Zivec M, Inglis SR, Fishwick CW, Gobec S, Charlier P, Luxen A, Schofield CJ. Structure guided development of potent reversibly binding penicillin binding protein inhibitors. Acs Medicinal Chemistry Letters. 2: 219-23. PMID 24900305 DOI: 10.1021/Ml100260X |
0.704 |
|
| 2011 |
McPhillie MJ, Trowbridge R, Mariner KR, O'Neill AJ, Johnson AP, Chopra I, Fishwick CW. Structure-based ligand design of novel bacterial RNA polymerase inhibitors. Acs Medicinal Chemistry Letters. 2: 729-34. PMID 24900260 DOI: 10.1021/Ml200087M |
0.384 |
|
| 2011 |
Foster TL, Verow M, Wozniak AL, Bentham MJ, Thompson J, Atkins E, Weinman SA, Fishwick C, Foster R, Harris M, Griffin S. Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel. Hepatology (Baltimore, Md.). 54: 79-90. PMID 21520195 DOI: 10.1002/Hep.24371 |
0.37 |
|
| 2010 |
Agarwal AK, Fishwick CW. Structure-based design of anti-infectives. Annals of the New York Academy of Sciences. 1213: 20-45. PMID 21175675 DOI: 10.1111/J.1749-6632.2010.05859.X |
0.339 |
|
| 2010 |
Miller K, Dunsmore CJ, Leeds JA, Patching SG, Sachdeva M, Blake KL, Stubbings WJ, Simmons KJ, Henderson PJ, De Los Angeles J, Fishwick CW, Chopra I. Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ). The Journal of Antimicrobial Chemotherapy. 65: 2566-73. PMID 20861142 DOI: 10.1093/Jac/Dkq349 |
0.697 |
|
| 2010 |
Majeed Y, Agarwal AK, Naylor J, Seymour VA, Jiang S, Muraki K, Fishwick CW, Beech DJ. Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels. British Journal of Pharmacology. 161: 430-41. PMID 20735426 DOI: 10.1111/J.1476-5381.2010.00892.X |
0.305 |
|
| 2010 |
Simmons KJ, Chopra I, Fishwick CW. Structure-based discovery of antibacterial drugs. Nature Reviews. Microbiology. 8: 501-10. PMID 20551974 DOI: 10.1038/Nrmicro2349 |
0.698 |
|
| 2010 |
Cowen D, Bedingfield P, McConkey GA, Fishwick CW, Johnson AP. A study of the effects of substituents on the selectivity of the binding of N-arylaminomethylene malonate inhibitors to DHODH. Bioorganic & Medicinal Chemistry Letters. 20: 1284-7. PMID 20034791 DOI: 10.1016/J.Bmcl.2009.11.079 |
0.364 |
|
| 2009 |
Yi Mok N, Chadwick J, Kellett KA, Hooper NM, Johnson AP, Fishwick CW. Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening. Bioorganic & Medicinal Chemistry Letters. 19: 6770-4. PMID 19854048 DOI: 10.1016/J.Bmcl.2009.09.103 |
0.385 |
|
| 2009 |
StGelais C, Foster TL, Verow M, Atkins E, Fishwick CW, Rowlands D, Harris M, Griffin S. Determinants of hepatitis C virus p7 ion channel function and drug sensitivity identified in vitro. Journal of Virology. 83: 7970-81. PMID 19493992 DOI: 10.1128/Jvi.00521-09 |
0.325 |
|
| 2009 |
Davies M, Heikkilä T, McConkey GA, Fishwick CW, Parsons MR, Johnson AP. Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases. Journal of Medicinal Chemistry. 52: 2683-93. PMID 19351152 DOI: 10.1021/Jm800963T |
0.413 |
|
| 2009 |
Blake KL, O'Neill AJ, Mengin-Lecreulx D, Henderson PJ, Bostock JM, Dunsmore CJ, Simmons KJ, Fishwick CW, Leeds JA, Chopra I. The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors. Molecular Microbiology. 72: 335-43. PMID 19298367 DOI: 10.1111/J.1365-2958.2009.06648.X |
0.694 |
|
| 2009 |
Sova M, Cadez G, Turk S, Majce V, Polanc S, Batson S, Lloyd AJ, Roper DI, Fishwick CW, Gobec S. Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB). Bioorganic & Medicinal Chemistry Letters. 19: 1376-9. PMID 19196510 DOI: 10.1016/J.Bmcl.2009.01.034 |
0.314 |
|
| 2008 |
Dunsmore CJ, Miller K, Blake KL, Patching SG, Henderson PJ, Garnett JA, Stubbings WJ, Phillips SE, Palestrant DJ, Angeles Jde L, Leeds JA, Chopra I, Fishwick CW. 2-Aminotetralones: novel inhibitors of MurA and MurZ. Bioorganic & Medicinal Chemistry Letters. 18: 1730-4. PMID 18261901 DOI: 10.1016/J.Bmcl.2008.01.089 |
0.359 |
|
| 2008 |
Agarwal AK, Johnson AP, Fishwick CW. Synthesis of de novo designed small-molecule inhibitors of bacterial RNA polymerase Tetrahedron. 64: 10049-10054. DOI: 10.1016/J.Tet.2008.08.037 |
0.339 |
|
| 2007 |
Heikkilä T, Ramsey C, Davies M, Galtier C, Stead AM, Johnson AP, Fishwick CW, Boa AN, McConkey GA. Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase. Journal of Medicinal Chemistry. 50: 186-91. PMID 17228860 DOI: 10.1021/Jm060687J |
0.403 |
|
| 2006 |
Heikkilä T, Thirumalairajan S, Davies M, Parsons MR, McConkey AG, Fishwick CW, Johnson AP. The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. Bioorganic & Medicinal Chemistry Letters. 16: 88-92. PMID 16236496 DOI: 10.1016/J.Bmcl.2005.09.045 |
0.318 |
|
| 2003 |
Horton JR, Bostock JM, Chopra I, Hesse L, Phillips SE, Adams DJ, Johnson AP, Fishwick CW. Macrocyclic inhibitors of the bacterial cell wall biosynthesis enzyme MurD. Bioorganic & Medicinal Chemistry Letters. 13: 1557-60. PMID 12699754 DOI: 10.1016/S0960-894X(03)00176-8 |
0.332 |
|
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