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Thanh T. Lam, Ph.D. - Publications

Affiliations: 
2007 Chemistry University of California, San Diego, La Jolla, CA 
Area:
Organic Chemistry
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10 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Lam T, Hilgers MT, Cunningham ML, Kwan BP, Nelson KJ, Brown-Driver V, Ong V, Trzoss M, Hough G, Shaw KJ, Finn J. Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines. Journal of Medicinal Chemistry. 57: 651-68. PMID 24428639 DOI: 10.1021/Jm401204G  0.417
2013 Tari LW, Li X, Trzoss M, Bensen DC, Chen Z, Lam T, Zhang J, Lee SJ, Hough G, Phillipson D, Akers-Rodriguez S, Cunningham ML, Kwan BP, Nelson KJ, Castellano A, et al. Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents. Plos One. 8: e84409. PMID 24386374 DOI: 10.1371/Journal.Pone.0084409  0.335
2013 Tari LW, Trzoss M, Bensen DC, Li X, Chen Z, Lam T, Zhang J, Creighton CJ, Cunningham ML, Kwan B, Stidham M, Shaw KJ, Lightstone FC, Wong SE, Nguyen TB, et al. Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Bioorganic & Medicinal Chemistry Letters. 23: 1529-36. PMID 23352267 DOI: 10.1016/J.Bmcl.2012.11.032  0.318
2013 Trzoss M, Bensen DC, Li X, Chen Z, Lam T, Zhang J, Creighton CJ, Cunningham ML, Kwan B, Stidham M, Nelson K, Brown-Driver V, Castellano A, Shaw KJ, Lightstone FC, et al. Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: development of inhibitors with broad spectrum, Gram-negative antibacterial activity. Bioorganic & Medicinal Chemistry Letters. 23: 1537-43. PMID 23294697 DOI: 10.1016/J.Bmcl.2012.11.073  0.382
2011 Li X, Hilgers M, Cunningham M, Chen Z, Trzoss M, Zhang J, Kohnen L, Lam T, Creighton C, G C K, Nelson K, Kwan B, Stidham M, Brown-Driver V, Shaw KJ, et al. Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines. Bioorganic & Medicinal Chemistry Letters. 21: 5171-6. PMID 21831637 DOI: 10.1016/J.Bmcl.2011.07.059  0.347
2008 Bluhm U, Boucher JL, Buss U, Clement B, Friedrich F, Girreser U, Heber D, Lam T, Lepoivre M, Rostaie-Gerylow M, Wolschendorf U. Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases. European Journal of Medicinal Chemistry. 44: 2877-87. PMID 19144449 DOI: 10.1016/j.ejmech.2008.12.007  0.314
2007 Traves PG, Hortelano S, Zeini M, Chao TH, Lam T, Neuteboom ST, Theodorakis EA, Palladino MA, Castrillo A, Bosca L. Selective activation of liver X receptors by acanthoic acid-related diterpenes. Molecular Pharmacology. 71: 1545-53. PMID 17329499 DOI: 10.1124/Mol.106.031906  0.583
2007 Batova A, Lam T, Wascholowski V, Yu AL, Giannis A, Theodorakis EA. Synthesis and evaluation of caged Garcinia xanthones. Organic & Biomolecular Chemistry. 5: 494-500. PMID 17252132 DOI: 10.1039/B612903J  0.638
2005 Chao TH, Lam T, Vong BG, Través PG, Hortelano S, Chowdhury C, Bahjat FR, Lloyd GK, Moldawer LL, Boscá L, Palladino MA, Theodorakis EA. A new family of synthetic diterpenes that regulates cytokine synthesis by inhibiting IkappaBalpha phosphorylation. Chembiochem : a European Journal of Chemical Biology. 6: 133-44. PMID 15540220 DOI: 10.1002/Cbic.200400089  0.526
2003 Lam T, Ling T, Chowdhury C, Chao TH, Bahjat FR, Lloyd GK, Moldawer LL, Palladino MA, Theodorakis EA. Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters. 13: 3217-21. PMID 12951096 DOI: 10.1016/S0960-894X(03)00669-3  0.675
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