| Year |
Citation |
Score |
| 2010 |
Frantom PA, Coward JK, Blanchard JS. UDP-(5F)-GlcNAc acts as a slow-binding inhibitor of MshA, a retaining glycosyltransferase. Journal of the American Chemical Society. 132: 6626-7. PMID 20411981 DOI: 10.1021/Ja101231A |
0.336 |
|
| 2010 |
Wang P, Wang Q, Yang Y, Coward JK, Nzila A, Sims PF, Hyde JE. Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition. Molecular and Biochemical Parasitology. 172: 41-51. PMID 20350571 DOI: 10.1016/J.Molbiopara.2010.03.012 |
0.383 |
|
| 2010 |
McGuire JJ, Bartley DM, Tomsho JW, Haile WH, Coward JK. Corrigendum to "Inhibition of human folylpolyglutamate synthetase by diastereomeric phosphinic acid mimics of the tetrahedral intermediate" [Archives of Biochemistry and Biophysics 488 (2009) 140-145] (DOI:10.1016/j.abb.2009.06.017) Archives of Biochemistry and Biophysics. 493: 250. DOI: 10.1016/J.Abb.2009.11.011 |
0.782 |
|
| 2010 |
MALACHOWSKI WP, COWARD JK. ChemInform Abstract: The Chemistry of Phosphapeptides: Investigations on the Synthesis of Phosphonamidate, Phosphonate, and Phosphinate Analogues of Glutamyl-. gamma.-glutamate. Cheminform. 26: no-no. DOI: 10.1002/chin.199525214 |
0.736 |
|
| 2010 |
HART BP, COWARD JK. ChemInform Abstract: The Synthesis of DL-3,3-Difluoroglutamic Acid (IX) from a 3- Oxoprolinol Derivative (I). Cheminform. 24: no-no. DOI: 10.1002/chin.199341250 |
0.766 |
|
| 2010 |
COWARD JK, MCGUIRE JJ, GALIVAN J. ChemInform Abstract: The Influence of Fluoro Substituents on the Reactivity of Carboxylic Acids, Amides, and Peptides in Enzyme-Catalyzed Reactions Cheminform. 22: no-no. DOI: 10.1002/chin.199138325 |
0.327 |
|
| 2009 |
McGuire JJ, Bartley DM, Tomsho JW, Haile WH, Coward JK. Inhibition of human folylpolyglutamate synthetase by diastereomeric phosphinic acid mimics of the tetrahedral intermediate. Archives of Biochemistry and Biophysics. 488: 140-5. PMID 19563773 DOI: 10.1016/J.Abb.2009.06.017 |
0.781 |
|
| 2009 |
Majumdar D, Alexander MD, Coward JK. Synthesis of isopeptide epoxide peptidomimetics. The Journal of Organic Chemistry. 74: 617-27. PMID 19086784 DOI: 10.1021/Jo801907P |
0.677 |
|
| 2009 |
Hagena TL, Coward JK. Fluoridolysis of 5,6-epoxy carbohydrates: application to the synthesis of 5-fluoro lactosamine and isolactosamine glycosides Tetrahedron Asymmetry. 20: 781-794. DOI: 10.1016/J.Tetasy.2009.03.025 |
0.749 |
|
| 2008 |
Oza SL, Chen S, Wyllie S, Coward JK, Fairlamb AH. ATP-dependent ligases in trypanothione biosynthesis--kinetics of catalysis and inhibition by phosphinic acid pseudopeptides. The Febs Journal. 275: 5408-21. PMID 18959765 DOI: 10.1111/J.1742-4658.2008.06670.X |
0.323 |
|
| 2008 |
Coward JK, McGuire JJ. Mechanism-based inhibitors of folylpoly-gamma-glutamate synthetase and gamma-glutamyl hydrolase: control of folylpoly-gamma-glutamate homeostasis as a drug target. Vitamins and Hormones. 79: 347-73. PMID 18804701 DOI: 10.1016/S0083-6729(08)00412-3 |
0.493 |
|
| 2008 |
Tomsho JW, Moran RG, Coward JK. Concentration-dependent processivity of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase. Biochemistry. 47: 9040-50. PMID 18672898 DOI: 10.1021/Bi800406W |
0.765 |
|
| 2008 |
Alexander JP, Ryan TJ, Ballou DP, Coward JK. Gamma-glutamyl hydrolase: kinetic characterization of isopeptide hydrolysis using fluorogenic substrates. Biochemistry. 47: 1228-39. PMID 18171026 DOI: 10.1021/Bi701607V |
0.404 |
|
| 2007 |
Hartman MC, Jiang S, Rush JS, Waechter CJ, Coward JK. Glycosyltransferase mechanisms: impact of a 5-fluoro substituent in acceptor and donor substrates on catalysis. Biochemistry. 46: 11630-8. PMID 17883281 DOI: 10.1021/Bi700863S |
0.669 |
|
| 2007 |
Yang Y, Coward JK. Synthesis of p-aminophenyl aryl H-phosphinic acids and esters via cross-coupling reactions: elaboration to phosphinic acid pseudopeptide analogues of pteroyl glutamic acid and related antifolates. The Journal of Organic Chemistry. 72: 5748-58. PMID 17602593 DOI: 10.1021/jo0707840 |
0.334 |
|
| 2006 |
Feng Y, Coward JK. Prodrug forms of N-[(4-deoxy-4-amino-10-methyl)pteroyl]glutamate-gamma-[psiP(O)(OH)]-glutarate, a potent inhibitor of folylpoly-gamma-glutamate synthetase: synthesis and hydrolytic stability. Journal of Medicinal Chemistry. 49: 770-88. PMID 16420062 DOI: 10.1021/jm050871p |
0.355 |
|
| 2006 |
Bartley DM, Coward JK. Regioselective synthesis of alpha-methyl 2-methyleneglutarate via a novel lactonization-elimination rearrangement. The Journal of Organic Chemistry. 71: 372-4. PMID 16388662 DOI: 10.1021/Jo051854A |
0.705 |
|
| 2005 |
Tomsho JW, McGuire JJ, Coward JK. Synthesis of (6R)- and (6S)-5,10-dideazatetrahydrofolate oligo-gamma-glutamates: kinetics of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase. Organic & Biomolecular Chemistry. 3: 3388-98. PMID 16132101 DOI: 10.1039/B505907K |
0.761 |
|
| 2005 |
Bartley DM, Coward JK. A stereoselective synthesis of phosphinic acid phosphapeptides corresponding to glutamyl-gamma-glutamate and incorporation into potent inhibitors of folylpoly-gamma-glutamyl synthetase. The Journal of Organic Chemistry. 70: 6757-74. PMID 16095295 DOI: 10.1021/Jo0507439 |
0.753 |
|
| 2005 |
Ganguli ARS, Coward JK. α:β Selectivity in the synthesis of 3-substituted, 4-methyl umbelliferone glycosides of N-acetyl glucosamine and chitobiose Tetrahedron Asymmetry. 16: 411-424. DOI: 10.1016/J.Tetasy.2004.11.053 |
0.358 |
|
| 2003 |
Volk EL, Pankuch JJ, Chave KJ, Coward JK, Schneider E. A rapid assay for the quantitation of gamma-glutamyl hydrolase using a fluorogenic peptide as substrate. Biotechniques. 35: 926-8, 930, 932. PMID 14628664 DOI: 10.2144/03355Bm04 |
0.758 |
|
| 2003 |
McGuire JJ, Haile WH, Valiaeva N, Bartley D, Guo J, Coward JK. Potent inhibition of human folylpolyglutamate synthetase by a phosphinic acid mimic of the tetrahedral reaction intermediate. Biochemical Pharmacology. 65: 315-8. PMID 12527324 DOI: 10.1016/S0006-2952(02)01602-7 |
0.742 |
|
| 2002 |
Hartman MC, Coward JK. Synthesis of 5-fluoro N-acetylglucosamine glycosides and pyrophosphates via epoxide fluoridolysis: versatile reagents for the study of glycoconjugate biochemistry. Journal of the American Chemical Society. 124: 10036-53. PMID 12188668 DOI: 10.1021/ja0127234 |
0.669 |
|
| 2002 |
Tsukamoto T, Flanary JM, Rojas C, Slusher BS, Valiaeva N, Coward JK. Phosphonate and phosphinate analogues of N-acylated gamma-glutamylglutamate. potent inhibitors of glutamate carboxypeptidase II. Bioorganic & Medicinal Chemistry Letters. 12: 2189-92. PMID 12127534 DOI: 10.1016/S0960-894X(02)00360-8 |
0.382 |
|
| 2002 |
Srinivasan A, Coward JK. A biotin capture assay for oligosaccharyltransferase. Analytical Biochemistry. 306: 328-35. PMID 12123673 DOI: 10.1006/Abio.2002.5699 |
0.589 |
|
| 2002 |
Konas DW, Pankuch JJ, Coward JK. The synthesis of (2S)-4,4-difluoroglutamyl γ-peptides based on Garner's aldehyde and fluoro-reformatsky chemistry Synthesis. 2616-2626. DOI: 10.1055/S-2002-35616 |
0.772 |
|
| 2001 |
Konas DW, Coward JK. Electrophilic fluorination of pyroglutamic acid derivatives: application of substrate-dependent reactivity and diastereoselectivity to the synthesis of optically active 4-fluoroglutamic acids. The Journal of Organic Chemistry. 66: 8831-42. PMID 11749613 DOI: 10.1021/Jo0106804 |
0.805 |
|
| 2001 |
Valiaeva N, Bartley D, Konno T, Coward JK. Phosphinic acid pseudopeptides analogous to glutamyl-gamma-glutamate: synthesis and coupling to pteroyl azides leads to potent inhibitors of folylpoly-gamma-glutamate synthetase. The Journal of Organic Chemistry. 66: 5146-54. PMID 11463268 DOI: 10.1021/Jo010283T |
0.768 |
|
| 2001 |
Pankuch JJ, Coward JK. N-Me-pAB-Glu-gamma-Glu-gamma-Tyr(3-NO(2)): an internally quenched fluorogenic gamma-glutamyl hydrolase substrate. Bioorganic & Medicinal Chemistry Letters. 11: 1561-4. PMID 11412981 DOI: 10.1016/S0960-894X(01)00103-2 |
0.77 |
|
| 2000 |
Varnado BL, Voci CJ, Meyer LM, Coward JK. Circular dichroism and NMR studies of metabolically stablealpha-methylpolyamines: spectral comparison with naturally occurring polyamines. Bioorganic Chemistry. 28: 395-408. PMID 11352474 DOI: 10.1006/Bioo.2000.1195 |
0.304 |
|
| 1999 |
Konas DW, Coward JK. Synthesis of L-4,4-difluoroglutamic acid via electrophilic difluorination of a lactam. Organic Letters. 1: 2105-7. PMID 10836063 DOI: 10.1021/Ol991150L |
0.792 |
|
| 1999 |
Reddy A, Gibbs BS, Liu YL, Coward JK, Changchien LM, Maley F. Glycosylation of the overlapping sequons in yeast external invertase: effect of amino acid variation on site selectivity in vivo and in vitro. Glycobiology. 9: 547-55. PMID 10336987 DOI: 10.1093/Glycob/9.6.547 |
0.356 |
|
| 1999 |
Gibbs BS, Coward JK. Dolichylpyrophosphate oligosaccharides: large-scale isolation and evaluation as oligosaccharyltransferase substrates. Bioorganic & Medicinal Chemistry. 7: 441-7. PMID 10220030 DOI: 10.1016/S0968-0896(98)00268-5 |
0.36 |
|
| 1999 |
Coward JK. Synthesis and biochemical studies of phosphorus-based "tetrahedral mimics" as inhibitors of ATP-dependent ligases Phosphorus, Sulfur and Silicon and Related Elements. 144: 113-116. DOI: 10.1080/10426509908546195 |
0.384 |
|
| 1998 |
Chen S, Coward JK. Investigations on New Strategies for the Facile Synthesis of Polyfunctionalized Phosphinates: Phosphinopeptide Analogues of Glutathionylspermidine. The Journal of Organic Chemistry. 63: 502-509. PMID 11672038 |
0.329 |
|
| 1998 |
Xu T, Khanna H, Coward JK. The design, synthesis, and initial evaluation of benzophenone-containing peptides as potential photoaffinity labels of oligosaccharyltransferase. Bioorganic & Medicinal Chemistry. 6: 1821-34. PMID 9839012 DOI: 10.1016/S0968-0896(98)00135-7 |
0.684 |
|
| 1998 |
Tsukamoto T, Haile WH, McGuire JJ, Coward JK. Mechanism-based inhibition of human folylpolyglutamate synthetase: design, synthesis, and biochemical characterization of a phosphapeptide mimic of the tetrahedral intermediate. Archives of Biochemistry and Biophysics. 355: 109-18. PMID 9647673 DOI: 10.1006/Abbi.1998.0703 |
0.404 |
|
| 1998 |
Berdis AJ, Lee I, Coward JK, Stephens C, Wright R, Shapiro L, Benkovic SJ. A cell cycle-regulated adenine DNA methyltransferase from Caulobacter crescentus processively methylates GANTC sites on hemimethylated DNA. Proceedings of the National Academy of Sciences of the United States of America. 95: 2874-9. PMID 9501183 DOI: 10.1073/Pnas.95.6.2874 |
0.477 |
|
| 1998 |
Xu T, Werner RM, Lee KC, Fettinger JC, Davis JT, Coward JK. Synthesis and Evaluation of Tripeptides Containing Asparagine Analogues as Potential Substrates or Inhibitors of Oligosaccharyltransferase Journal of Organic Chemistry. 63: 4767-4778. DOI: 10.1021/Jo9802123 |
0.573 |
|
| 1997 |
Xu T, Coward JK. 13C- and 15N-labeled peptide substrates as mechanistic probes of oligosaccharyltransferase. Biochemistry. 36: 14683-9. PMID 9398187 DOI: 10.1021/Bi9719511 |
0.497 |
|
| 1997 |
Lin CH, Chen S, Kwon DS, Coward JK, Walsh CT. Aldehyde and phosphinate analogs of glutathione and glutathionylspermidine: potent, selective binding inhibitors of the E. coli bifunctional glutathionylspermidine synthetase/amidase. Chemistry & Biology. 4: 859-66. PMID 9384533 DOI: 10.1016/S1074-5521(97)90118-6 |
0.365 |
|
| 1997 |
Chen S, Lin CH, Walsh CT, Coward JK. Novel inhibitors of trypanothione biosynthesis: Synthesis and evaluation of a phosphinate analog of glutathionyl spermidine (GSP), a potent, slow-binding inhibitor of GSP synthetase Bioorganic and Medicinal Chemistry Letters. 7: 505-510. DOI: 10.1016/S0960-894X(97)00061-9 |
0.343 |
|
| 1996 |
McGuire JJ, Tsukamoto T, Hart BP, Coward JK, Kalman TI, Galivan J. Exploitation of folate and antifolate polyglutamylation to achieve selective anticancer chemotherapy. Investigational New Drugs. 14: 317-23. PMID 8958187 DOI: 10.1007/Bf00194535 |
0.778 |
|
| 1996 |
McGuire JJ, Hart BP, Haile WH, Magee KJ, Rhee M, Bolanowska WE, Russell C, Galivan J, Paul B, Coward JK. Biological properties of fluoroglutamate-containing analogs of folates and methotrexate with altered capacities to form poly (gamma-glutamate) metabolites. Biochemical Pharmacology. 52: 1295-303. PMID 8937438 DOI: 10.1016/0006-2952(96)00485-6 |
0.761 |
|
| 1996 |
Burns MR, Coward JK. Synthesis of complex delta-acetylenic amino acids as potential multisubstrate adduct inhibitors of methyltransferases. Bioorganic & Medicinal Chemistry. 4: 1455-70. PMID 8894103 DOI: 10.1016/0968-0896(96)00139-3 |
0.744 |
|
| 1996 |
Tsukamoto T, Haile WH, McGuire JJ, Coward JK. Synthesis and biological evaluation of N alpha-(4-amino-4-deoxy-10-methylpteroyl)-DL-4,4-difluoroornithine. Journal of Medicinal Chemistry. 39: 2536-40. PMID 8691451 DOI: 10.1021/Jm960046W |
0.455 |
|
| 1996 |
Tsukamoto T, Kitazume T, McGuire JJ, Coward JK. Synthesis and biological evaluation of DL-4,4-difluoroglutamic acid and DL-gamma,gamma-difluoromethotrexate. Journal of Medicinal Chemistry. 39: 66-72. PMID 8568828 DOI: 10.1021/Jm950514M |
0.485 |
|
| 1996 |
Hart BP, Haile WH, Licato NJ, Bolanowska WE, McGuire JJ, Coward JK. Synthesis and biological activity of folic acid and methotrexate analogues containing L-threo-(2S,4S)-4-fluoroglutamic acid and DL-3,3-difluoroglutamic acid. Journal of Medicinal Chemistry. 39: 56-65. PMID 8568827 DOI: 10.1021/Jm950515E |
0.783 |
|
| 1996 |
Tsukamoto T, Coward JK. Facile synthesis of DL-4,4-difluoroornithine, DL-4,4-difluoroglutamine, and γ-DL-4,4-difluoroglutamyl-containing peptides: Regiospecific addition of nucleophiles to N-Cbz-di-tert-butyl-DL-4,4-difluoroglutamate Journal of Organic Chemistry. 61: 2497-2500. DOI: 10.1021/Jo952044+ |
0.429 |
|
| 1995 |
McGuire JJ, Hart BP, Haile WH, Rhee MS, Galivan J, Coward JK. DL-beta,beta-difluoroglutamic acid mediates position-dependent enhancement or termination of pteroylpoly(gamma-glutamate) synthesis catalyzed by folylpolyglutamate synthetase. Archives of Biochemistry and Biophysics. 321: 319-28. PMID 7646057 DOI: 10.1006/abbi.1995.1401 |
0.713 |
|
| 1995 |
Pegg AE, Poulin R, Coward JK. Use of aminopropyltransferase inhibitors and of non-metabolizable analogs to study polyamine regulation and function. The International Journal of Biochemistry & Cell Biology. 27: 425-42. PMID 7641073 DOI: 10.1016/1357-2725(95)00007-C |
0.368 |
|
| 1995 |
Lakanen JR, Pegg AE, Coward JK. Synthesis and biochemical evaluation of adenosylspermidine, a nucleoside-polyamine adduct inhibitor of spermidine synthase. Journal of Medicinal Chemistry. 38: 2714-27. PMID 7629810 DOI: 10.1021/Jm00014A023 |
0.791 |
|
| 1995 |
Yang J, Xiao L, Berkey KA, Tamez PA, Coward JK, Casero RA. Significant induction of spermidine/spermine N1-acetyltransferase without cytotoxicity by the growth-supporting polyamine analogue 1,12-dimethylspermine. Journal of Cellular Physiology. 165: 71-6. PMID 7559809 DOI: 10.1002/Jcp.1041650109 |
0.314 |
|
| 1995 |
Fang X, Gibbs BS, Coward JK. Synthesis and evaluation of synthetic analogues of dolichyl-P-P-chitobiose as oligosaccharyltransferase substrates Bioorganic and Medicinal Chemistry Letters. 5: 2701-2706. DOI: 10.1016/0960-894X(95)00460-B |
0.378 |
|
| 1994 |
Byers TL, Lakanen JR, Coward JK, Pegg AE. The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine. The Biochemical Journal. 303: 363-8. PMID 7980394 DOI: 10.1042/Bj3030363 |
0.767 |
|
| 1994 |
Liu YL, Hoops GC, Coward JK. A comparison of proteins and peptides as substrates for microsomal and solubilized oligosaccharyltransferase. Bioorganic & Medicinal Chemistry. 2: 1133-41. PMID 7757412 DOI: 10.1016/S0968-0896(00)82065-9 |
0.426 |
|
| 1994 |
Malachowski WP, Coward JK. The Chemistry of Phosphapeptides: Investigations on the Synthesis of Phosphonamidate, Phosphonate, and Phosphinate Analogs of Glutamyl-.gamma.-glutamate Journal of Organic Chemistry. 59: 7625-7634. DOI: 10.1021/Jo00104A017 |
0.748 |
|
| 1994 |
Malachowski WP, Coward JK. The chemistry of phosphapeptides: Formation of functionalized phosphonochloridates under mild conditions and their reaction with alcohols and amines Journal of Organic Chemistry. 59: 7616-7624. DOI: 10.1021/Jo00104A016 |
0.685 |
|
| 1994 |
Malachowski WP, Coward JK. The chemistry of phosphapeptides: Investigations on the synthesis of phosphonamidate, phosphonate, and phosphinate analogues of glutamyl-γ-glutamate Journal of Organic Chemistry. 59: 7625-7634. |
0.729 |
|
| 1993 |
Poulin R, Coward JK, Lakanen JR, Pegg AE. Enhancement of the spermidine uptake system and lethal effects of spermidine overaccumulation in ornithine decarboxylase-overproducing L1210 cells under hyposmotic stress. The Journal of Biological Chemistry. 268: 4690-8. PMID 8444843 |
0.769 |
|
| 1993 |
Pegg AE, Coward JK. Effect of N-(n-butyl)-1,3-diaminopropane on polyamine metabolism, cell growth and sensitivity to chloroethylating agents. Biochemical Pharmacology. 46: 717-24. PMID 8395844 DOI: 10.1016/0006-2952(93)90559-F |
0.358 |
|
| 1993 |
Lee J, Coward JK. Oligosaccharyltransferase: synthesis and use of deuterium-labeled peptide substrates as mechanistic probes. Biochemistry. 32: 6794-801. PMID 8329402 DOI: 10.1021/Bi00077A034 |
0.347 |
|
| 1993 |
Hart BP, Coward JK. The synthesis of DL-3,3-Difluoroglutamic acid from a 3-oxoprolinol derivative Tetrahedron Letters. 34: 4917-4920. DOI: 10.1016/S0040-4039(00)74045-7 |
0.777 |
|
| 1993 |
Burns MR, Coward JK. A facile one-pot synthesis of homopropargylic alcohols from terminal acetylenes Journal of Organic Chemistry. 58: 528-532. |
0.621 |
|
| 1992 |
Lakanen JR, Coward JK, Pegg AE. alpha-Methyl polyamines: metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines. Journal of Medicinal Chemistry. 35: 724-34. PMID 1542099 DOI: 10.1021/Jm00082A013 |
0.774 |
|
| 1992 |
Lee J, Coward J. Correction. Enzyme-Catalyzed Glycosylation of Peptides Using a Synthetic Lipid Disaccharide Substrate The Journal of Organic Chemistry. 57: 7373-7373. DOI: 10.1021/Jo00052A605 |
0.308 |
|
| 1991 |
McGuire JJ, Bolanowska WE, Coward JK, Sherwood RF, Russell CA, Felschow DM. Biochemical and biological properties of methotrexate analogs containing D-glutamic acid or D-erythro, threo-4-fluoroglutamic acid. Biochemical Pharmacology. 42: 2400-3. PMID 1684899 DOI: 10.1016/0006-2952(91)90247-3 |
0.344 |
|
| 1990 |
Licato NJ, Coward JK, Nimec Z, Galivan J, Bolanowska WE, McGuire JJ. Synthesis of N-[N-(4-deoxy-4-amino-10-methylpteroyl)-4-fluoroglutamyl]- gamma-glutamate, an unusual substrate for folylpoly-gamma-glutamate synthetase and gamma-glutamyl hydrolase. Journal of Medicinal Chemistry. 33: 1022-7. PMID 2308134 |
0.345 |
|
| 1990 |
McGuire JJ, Haile WH, Bey P, Coward JK. DL-3,3-difluoroglutamate: an enhancer of folylpolyglutamate elongation. The Journal of Biological Chemistry. 265: 14073-9. PMID 1974895 |
0.37 |
|
| 1989 |
Woster PM, Black AY, Duff KJ, Coward JK, Pegg AE. Synthesis and biological evaluation of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase. Journal of Medicinal Chemistry. 32: 1300-7. PMID 2724300 DOI: 10.1021/Jm00126A026 |
0.589 |
|
| 1989 |
Pegg AE, Wechter R, Poulin R, Woster PM, Coward JK. Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells. Biochemistry. 28: 8446-53. PMID 2605194 DOI: 10.1021/Bi00447A026 |
0.561 |
|
| 1989 |
McGuire JJ, Haile WH, Coward JK. Interaction of D, L-erythro- and D,L-threo-gamma-fluoromethotrexate with human leukemia cell dihydrofolate reductase. Biochemical Pharmacology. 38: 4321-5. PMID 2597202 DOI: 10.1016/0006-2952(89)90532-7 |
0.338 |
|
| 1988 |
Coward JK. Aminopropyltransferases: mechanistic studies and the synthesis of specific inhibitors. Advances in Experimental Medicine and Biology. 250: 111-5. PMID 3076318 DOI: 10.1007/978-1-4684-5637-0_11 |
0.389 |
|
| 1986 |
Pegg AE, Coward JK, Talekar RR, Secrist JA. Effects of certain 5'-substituted adenosines on polyamine synthesis: selective inhibitors of spermine synthase. Biochemistry. 25: 4091-7. PMID 3091070 DOI: 10.1021/Bi00362A016 |
0.31 |
|
| 1985 |
McGuire JJ, Coward JK. DL-threo-4-fluoroglutamic acid. A chain-terminating inhibitor of folylpolyglutamate synthesis. The Journal of Biological Chemistry. 260: 6747-54. PMID 2860109 |
0.356 |
|
| 1984 |
TANG K, COWARD JK. ChemInform Abstract: SYNTHESIS OF ACYL PHOSPHONATE ANALOGS OF BIOLOGICALLY IMPORTANT ACYL PHOSPHATES: N-(2-AMINO-10-METHYLPTEROYL)-5-AMINO-2-OXOPENTANEPHOSPHONIC ACID Chemischer Informationsdienst. 15. DOI: 10.1002/chin.198427229 |
0.34 |
|
| 1983 |
Tang KC, Coward JK. Synthesis of acyl phosphonate analogues of biologically important acyl phosphates: N-(2-amino-10-methylpteroyl)-5-amino-2-oxopentanephosphonic acid Journal of Organic Chemistry. 48: 5001-5006. |
0.341 |
|
| 1980 |
McGuire JJ, Hsieh P, Coward JK, Bertino JR. Enzymatic synthesis of folylpolyglutamates. Characterization of the reaction and its products. The Journal of Biological Chemistry. 255: 5776-88. PMID 6892914 |
0.323 |
|
| 1977 |
Coward JK, Motola NC, Moyer JD. Polyamine biosynthesis in rat prostate. Substrate and inhibitor properties of 7-deaza analogues of decarboxylated S-adenosylmethionine and 5'-methylthioadenosine. Journal of Medicinal Chemistry. 20: 500-5. PMID 850235 |
0.318 |
|
| 1976 |
Chang CD, Coward JK. Analogues of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Synthesis of analogues with modifications at the 5'-thioether linkage. Journal of Medicinal Chemistry. 19: 684-91. PMID 1271409 |
0.316 |
|
| 1975 |
Heller JS, Canellakis ES, Bussolotti DL, Coward JK. Stable multisubstrate adducts as enzyme inhibitors. Potent inhibition of ornithine decarboxylase by N-(5'-phosphopyridoxyl)-ornithine. Biochimica Et Biophysica Acta. 403: 197-207. PMID 1174545 DOI: 10.1016/0005-2744(75)90022-4 |
0.338 |
|
| 1969 |
Coward JK, Bruice TC. Intramolecular amine-catalyzed ketone enolization. A search for concerted intramolecular general-base, general-acid catalysis Journal of the American Chemical Society. 91: 5339-5345. DOI: 10.1021/Ja01047A024 |
0.542 |
|
| 1969 |
Coward JK, Bruice TC. Catalytic reactions involving azomethines. XII. Mechanism of hydrolysis of primary and secondary enamines Journal of the American Chemical Society. 91: 5329-5339. DOI: 10.1021/Ja01047A023 |
0.461 |
|
| 1967 |
Baker BR, Coward JK. Irreversible enzyme inhibitors. LXXXIX. candidate active-site-directed irreversible inhibitors of dihydrofolic reductase. X. derivatives of 2-amino-5-benzamidopropyl-4-pyrimidinol Journal of Heterocyclic Chemistry. 4: 188-194. DOI: 10.1002/Jhet.5570040205 |
0.546 |
|
| 1966 |
Baker BR, Ho BT, Coward JK, Santi DV. Analogs of tetrahydrofolic acid. 33. Hydrophobic bonding to dihydrofolic reductase V. Inhibition by some pyrimidines bridged to benzoic acid. Journal of Pharmaceutical Sciences. 55: 302-8. PMID 5960176 DOI: 10.1002/Jps.2600550308 |
0.648 |
|
| 1966 |
Baker BR, Santi DV, Coward JK, Shapiro HS, Jordaan JH. Analogs of tetrahydrofolic acid. XXXIX . selective bromoacylation of polyfunctional molecules for synthesis of active-site-directed irreversible enzyme inhibitors Journal of Heterocyclic Chemistry. 3: 425-434. DOI: 10.1002/Jhet.5570030407 |
0.659 |
|
| 1965 |
Baker BR, Coward JK. Analogs of tetrahydrofolic acid XXII. Effects of modification of the bridge between the pyrimidyl and phenyl moieties of 2-amino-5-(3-anilinopropyl)-6-methyl-4-pyrimidinol thymidylate synthetase. 3. Journal of Pharmaceutical Sciences. 54: 714-9. PMID 5847011 DOI: 10.1002/Jps.2600540511 |
0.561 |
|
| Show low-probability matches. |
