| Year |
Citation |
Score |
| 2023 |
Van Oers TJ, Piercey A, Belovodskiy A, Reiz B, Donnelly BL, Vuong W, Lemieux MJ, Nieman JA, Auclair K, Vederas JC. Deuteration for Metabolic Stabilization of SARS-CoV-2 Inhibitors GC373 and Nirmatrelvir. Organic Letters. 25: 5885-5889. PMID 37523471 DOI: 10.1021/acs.orglett.3c02140 |
0.553 |
|
| 2022 |
Lamer T, van Belkum MJ, Wijewardane A, Chiorean S, Martin-Visscher LA, Vederas JC. SPI "sandwich": Combined SUMO-Peptide-Intein expression system and isolation procedure for improved stability and yield of peptides. Protein Science : a Publication of the Protein Society. 31: e4316. PMID 35481634 DOI: 10.1002/pro.4316 |
0.772 |
|
| 2020 |
Antwi I, Chiorean S, van Belkum MJ, Vederas JC. Unveiling the active isomer of cycloalanopine, a cyclic opine from LS8, through synthesis and analog production. Rsc Medicinal Chemistry. 11: 528-531. PMID 33479654 DOI: 10.1039/d0md00033g |
0.804 |
|
| 2020 |
Gómez-Mendoza DP, Lemos RP, Jesus I, Gorshkov V, McKinnie SMK, Vederas JC, Kjeldsen F, Guatimosim S, Santos RA, Pimenta AMC, Verano-Braga T. Moving pieces in a cellular puzzle: a cryptic peptide from the scorpion toxin Ts14 activates AKT and ERK signaling and decreases cardiac myocyte contractility via dephosphorylation of phospholamban. Journal of Proteome Research. PMID 32597192 DOI: 10.1021/Acs.Jproteome.0C00290 |
0.357 |
|
| 2019 |
Vuong W, Mosquera-Guagua F, Sanichar R, McDonald TR, Ernst OP, Wang L, Vederas JC. Synthesis of Chiral Spin-Labeled Amino Acids. Organic Letters. PMID 31820646 DOI: 10.1021/Acs.Orglett.9B04216 |
0.326 |
|
| 2019 |
Chiorean S, Antwi I, Carney DW, Kotsogianni I, Giltrap AM, Alexander FM, Cochrane SA, Payne RJ, Martin NI, Henninot A, Vederas JC. Dissecting the binding interactions of teixobactin with the bacterial cell wall precursor lipid II. Chembiochem : a European Journal of Chemical Biology. PMID 31552694 DOI: 10.1002/Cbic.201900504 |
0.789 |
|
| 2019 |
Fischer C, Ahn YC, Vederas JC. Catalytic mechanism and properties of pyridoxal 5'-phosphate independent racemases: how enzymes alter mismatched acidity and basicity. Natural Product Reports. PMID 30994146 DOI: 10.1039/C9Np00017H |
0.656 |
|
| 2019 |
Fischer C, Lamer T, Wang W, McKinnie SMK, Iturrioz X, Llorens-Cortes C, Oudit GY, Vederas JC. Plasma kallikrein cleaves and inactivates apelin-17: Palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents. European Journal of Medicinal Chemistry. 166: 119-124. PMID 30690406 DOI: 10.1016/J.Ejmech.2019.01.040 |
0.367 |
|
| 2018 |
Fischer C, Kwon M, Ro DK, van Belkum MJ, Vederas JC. Isolation, expression and biochemical characterization of recombinant hyoscyamine-6β-hydroxylase from - tuning the scopolamine production. Medchemcomm. 9: 888-892. PMID 30108978 DOI: 10.1039/C8Md00090E |
0.31 |
|
| 2018 |
Acedo JZ, Chiorean S, Vederas JC, van Belkum MJ. The expanding structural variety among bacteriocins from Gram-positive bacteria. Fems Microbiology Reviews. PMID 30085042 DOI: 10.1093/Femsre/Fuy033 |
0.404 |
|
| 2018 |
Ahn YC, Fischer C, van Belkum MJ, Vederas JC. PLP-independent racemization: mechanistic and mutational studies of O-ureidoserine racemase (DcsC). Organic & Biomolecular Chemistry. PMID 29362754 DOI: 10.1039/C7Ob03013D |
0.632 |
|
| 2018 |
Chiorean S, Vederas JC, van Belkum MJ. Identification and Heterologous Expression of the sec-Dependent Bacteriocin Faerocin MK from Enterococcus faecium M3K31. Probiotics and Antimicrobial Proteins. PMID 29306983 DOI: 10.1007/S12602-017-9374-7 |
0.38 |
|
| 2017 |
Towle KM, Vederas JC. Structural features of many circular and leaderless bacteriocins are similar to those in saposins and saposin-like peptides. Medchemcomm. 8: 276-285. PMID 30108744 DOI: 10.1039/C6Md00607H |
0.383 |
|
| 2017 |
Bakhtiary A, Cochrane SA, Mercier P, McKay RT, Miskolzie M, Sit CS, Vederas JC. Insights into the Mechanism of Action of the Two-Peptide Lantibiotic Lacticin 3147. Journal of the American Chemical Society. PMID 29164875 DOI: 10.1021/Jacs.7B04728 |
0.8 |
|
| 2017 |
Caldo KMP, Acedo JZ, Panigrahi R, Vederas JC, Weselake RJ, Lemieux MJ. Diacylglycerol acyltransferase 1 is regulated by its N-terminal domain in response to allosteric effectors. Plant Physiology. PMID 28827454 DOI: 10.1104/Pp.17.00934 |
0.349 |
|
| 2017 |
McKinnie SMK, Wang W, Fischer C, McDonald T, Kalin KR, Iturrioz X, Llorens-Cortes C, Oudit GY, Vederas JC. Synthetic Modification within the "RPRL" Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation. Journal of Medicinal Chemistry. PMID 28685579 DOI: 10.1021/Acs.Jmedchem.7B00723 |
0.364 |
|
| 2017 |
Sanichar R, Vederas JC. One-Step Transformation of Coenzyme A into Analogues by Transamidation. Organic Letters. PMID 28393528 DOI: 10.1021/Acs.Orglett.7B00291 |
0.362 |
|
| 2017 |
Acedo JZ, Towle KM, Lohans CT, Miskolzie M, McKay RT, Doerksen TA, Vederas JC, Martin-Visscher LA. Identification and three-dimensional structure of carnobacteriocin XY, a class IIb bacteriocin produced by Carnobacteria. Febs Letters. PMID 28391617 DOI: 10.1002/1873-3468.12648 |
0.798 |
|
| 2016 |
Zhong JC, Zhang ZZ, Wang W, McKinnie SM, Vederas JC, Oudit GY. Targeting the Apelin Pathway as a Novel Therapeutic Approach for Cardiovascular Diseases. Biochimica Et Biophysica Acta. PMID 27825851 DOI: 10.1016/J.Bbadis.2016.11.007 |
0.309 |
|
| 2016 |
Cochrane SA, Findlay B, Bakhtiary A, Acedo JZ, Rodriguez-Lopez EM, Mercier P, Vederas JC. Antimicrobial lipopeptide tridecaptin A1 selectively binds to Gram-negative lipid II. Proceedings of the National Academy of Sciences of the United States of America. PMID 27688760 DOI: 10.1073/Pnas.1608623113 |
0.782 |
|
| 2016 |
Towle KM, Lohans CT, Miskolzie M, Acedo JZ, van Belkum MJ, Vederas JC. Solution Structures of Phenol-Soluble Modulins α1, α3, and β2, Virulence Factors from Staphylococcus aureus. Biochemistry. PMID 27525453 DOI: 10.1021/Acs.Biochem.6B00615 |
0.697 |
|
| 2016 |
McKinnie SM, Fischer C, Tran KM, Wang W, Mosquera F, Oudit GY, Vederas JC. The Metalloprotease Neprilysin Degrades and Inactivates Apelin Peptides. Chembiochem : a European Journal of Chemical Biology. PMID 27377680 DOI: 10.1002/Cbic.201600244 |
0.353 |
|
| 2016 |
Wang W, McKinnie SM, Farhan M, Paul M, McDonald T, McLean B, Llorens-Cortes C, Hazra S, Murray AG, Vederas JC, Oudit GY. Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System. Hypertension. PMID 27217402 DOI: 10.1161/Hypertensionaha.115.06892 |
0.383 |
|
| 2016 |
Arbulu S, Frantzen C, Lohans CT, Cintas LM, Herranz C, Holo H, Diep DB, Vederas JC, Hernández PE. Draft Genome Sequence of the Bacteriocin-Producing Strain Enterococcus faecium M3K31, Isolated from Griffon Vultures (Gyps fulvus subsp. fulvus). Genome Announcements. 4. PMID 27013035 DOI: 10.1128/Genomea.00055-16 |
0.643 |
|
| 2016 |
Cochrane RV, Sanichar R, Lambkin GR, Reiz B, Xu W, Tang Y, Vederas JC. Production of New Cladosporin Analogues by Reconstitution of the Polyketide Synthases Responsible for the Biosynthesis of this Antimalarial Agent. Angewandte Chemie (International Ed. in English). 55: 664-8. PMID 26783060 DOI: 10.1002/Anie.201509345 |
0.637 |
|
| 2016 |
Acedo JZ, van Belkum MJ, Lohans CT, Towle KM, Miskolzie M, Vederas JC. Nuclear Magnetic Resonance Solution Structures of Lacticin Q and Aureocin A53 Reveal a Structural Motif Conserved among Leaderless Bacteriocins with Broad-Spectrum Activity. Biochemistry. PMID 26771761 DOI: 10.1021/Acs.Biochem.5B01306 |
0.693 |
|
| 2016 |
Cochrane RVK, Norquay AK, Vederas JC. Natural products and their derivatives as tRNA synthetase inhibitors and antimicrobial agents Medchemcomm. 7: 1535-1545. DOI: 10.1039/C6Md00274A |
0.614 |
|
| 2015 |
Cochrane SA, Li X, He S, Yu M, Wu M, Vederas JC. Synthesis of Tridecaptin-Antibiotic Conjugates with in Vivo Activity against Gram-Negative Bacteria. Journal of Medicinal Chemistry. PMID 26636619 DOI: 10.1021/Acs.Jmedchem.5B01578 |
0.741 |
|
| 2015 |
Cacho RA, Thuss J, Xu W, Sanichar R, Gao Z, Nguyen A, Vederas JC, Tang Y. Understanding Programming of Fungal Iterative Polyketide Synthases: the Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase. Journal of the American Chemical Society. PMID 26630357 DOI: 10.1021/Jacs.5B11814 |
0.708 |
|
| 2015 |
Arbulu S, Lohans CT, Van Belkum MJ, Cintas LM, Herranz C, Vederas JC, Hernández PE. Solution Structure of Enterocin HF, an Antilisterial Bacteriocin Produced by Enterococcus faecium M3K31. Journal of Agricultural and Food Chemistry. PMID 26585399 DOI: 10.1021/Acs.Jafc.5B03882 |
0.687 |
|
| 2015 |
Cochrane RV, Gao Z, Lambkin GR, Xu W, Winter JM, Marcus SL, Tang Y, Vederas JC. Comparison of 10,11-Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs. Chembiochem : a European Journal of Chemical Biology. PMID 26493380 DOI: 10.1002/Cbic.201500428 |
0.794 |
|
| 2015 |
Cochrane SA, Surgenor RR, Khey KM, Vederas JC. Total Synthesis and Stereochemical Assignment of the Antimicrobial Lipopeptide Cerexin A1. Organic Letters. 17: 5428-31. PMID 26465807 DOI: 10.1021/Acs.Orglett.5B02779 |
0.759 |
|
| 2015 |
Winter JM, Cascio D, Dietrich D, Sato M, Watanabe K, Sawaya MR, Vederas JC, Tang Y. Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis. Journal of the American Chemical Society. PMID 26172141 DOI: 10.1021/Jacs.5B04520 |
0.572 |
|
| 2015 |
Cochrane SA, Lohans CT, van Belkum MJ, Bels MA, Vederas JC. Studies on tridecaptin B1, a lipopeptide with activity against multidrug resistant Gram-negative bacteria. Organic & Biomolecular Chemistry. 13: 6073-81. PMID 25959079 DOI: 10.1039/C5Ob00780A |
0.798 |
|
| 2015 |
van Belkum MJ, Lohans CT, Vederas JC. Draft Genome Sequences of Paenibacillus polymyxa NRRL B-30509 and Paenibacillus terrae NRRL B-30644, Strains from a Poultry Environment That Produce Tridecaptin A and Paenicidins. Genome Announcements. 3. PMID 25908148 DOI: 10.1128/Genomea.00372-15 |
0.64 |
|
| 2015 |
Li J, Chaytor JL, Findlay B, McMullen LM, Smith DC, Vederas JC. Identification of didecyldimethylammonium salts and salicylic acid as antimicrobial compounds in commercial fermented radish kimchi. Journal of Agricultural and Food Chemistry. 63: 3053-8. PMID 25779084 DOI: 10.1021/Jf5063588 |
0.798 |
|
| 2015 |
Acedo JZ, van Belkum MJ, Lohans CT, McKay RT, Miskolzie M, Vederas JC. Solution structure of acidocin B, a circular bacteriocin produced by Lactobacillus acidophilus M46. Applied and Environmental Microbiology. 81: 2910-8. PMID 25681186 DOI: 10.1128/Aem.04265-14 |
0.693 |
|
| 2015 |
Lin XB, Lohans CT, Duar R, Zheng J, Vederas JC, Walter J, Gänzle M. Genetic determinants of reutericyclin biosynthesis in Lactobacillus reuteri. Applied and Environmental Microbiology. 81: 2032-41. PMID 25576609 DOI: 10.1128/Aem.03691-14 |
0.674 |
|
| 2015 |
Lohans CT, Van Belkum MJ, Li J, Vederas JC. Characterization of bacterial antimicrobial peptides active against Campylobacter jejuni Canadian Journal of Chemistry. 93: 381-388. DOI: 10.1139/Cjc-2014-0411 |
0.712 |
|
| 2014 |
Kwon M, Cochrane SA, Vederas JC, Ro DK. Molecular cloning and characterization of drimenol synthase from valerian plant (Valeriana officinalis). Febs Letters. 588: 4597-603. PMID 25447532 DOI: 10.1016/J.Febslet.2014.10.031 |
0.74 |
|
| 2014 |
Bai Y, Findlay B, Maldonado AF, Schieber A, Vederas JC, Gänzle MG. Novel pyrano and vinylphenol adducts of deoxyanthocyanidins in sorghum sourdough. Journal of Agricultural and Food Chemistry. 62: 11536-46. PMID 25370078 DOI: 10.1021/Jf503330B |
0.621 |
|
| 2014 |
Cochrane SA, Vederas JC. Unacylated tridecaptin A₁ acts as an effective sensitiser of Gram-negative bacteria to other antibiotics. International Journal of Antimicrobial Agents. 44: 493-9. PMID 25315408 DOI: 10.1016/J.Ijantimicag.2014.08.008 |
0.745 |
|
| 2014 |
Cochrane RV, Vederas JC. Highly selective but multifunctional oxygenases in secondary metabolism. Accounts of Chemical Research. 47: 3148-61. PMID 25250512 DOI: 10.1021/Ar500242C |
0.636 |
|
| 2014 |
Lohans CT, Li JL, Vederas JC. Structure and biosynthesis of carnolysin, a homologue of enterococcal cytolysin with D-amino acids. Journal of the American Chemical Society. 136: 13150-3. PMID 25207953 DOI: 10.1021/Ja5070813 |
0.71 |
|
| 2014 |
Cochrane SA, Vederas JC. Lipopeptides from Bacillus and Paenibacillus spp.: A Gold Mine of Antibiotic Candidates. Medicinal Research Reviews. PMID 24866700 DOI: 10.1002/Med.21321 |
0.745 |
|
| 2014 |
Hu Y, Dietrich D, Xu W, Patel A, Thuss JA, Wang J, Yin WB, Qiao K, Houk KN, Vederas JC, Tang Y. A carbonate-forming Baeyer-Villiger monooxygenase. Nature Chemical Biology. 10: 552-4. PMID 24838010 DOI: 10.1038/Nchembio.1527 |
0.54 |
|
| 2014 |
Cochrane SA, Findlay B, Vederas JC, Ratemi ES. Key residues in octyl-tridecaptin A1 analogues linked to stable secondary structures in the membrane. Chembiochem : a European Journal of Chemical Biology. 15: 1295-9. PMID 24816483 DOI: 10.1002/Cbic.201402024 |
0.8 |
|
| 2014 |
Cochrane SA, Lohans CT, Brandelli JR, Mulvey G, Armstrong GD, Vederas JC. Synthesis and structure-activity relationship studies of N-terminal analogues of the antimicrobial peptide tridecaptin A(1). Journal of Medicinal Chemistry. 57: 1127-31. PMID 24479847 DOI: 10.1021/Jm401779D |
0.815 |
|
| 2014 |
Tulini FL, Lohans CT, Bordon KC, Zheng J, Arantes EC, Vederas JC, De Martinis EC. Purification and characterization of antimicrobial peptides from fish isolate Carnobacterium maltaromaticum C2: Carnobacteriocin X and carnolysins A1 and A2. International Journal of Food Microbiology. 173: 81-8. PMID 24412962 DOI: 10.1016/J.Ijfoodmicro.2013.12.019 |
0.704 |
|
| 2014 |
Lohans CT, van Belkum MJ, Cochrane SA, Huang Z, Sit CS, McMullen LM, Vederas JC. Biochemical, structural, and genetic characterization of tridecaptin A₁, an antagonist of Campylobacter jejuni. Chembiochem : a European Journal of Chemical Biology. 15: 243-9. PMID 24382692 DOI: 10.1002/Cbic.201300595 |
0.782 |
|
| 2014 |
McKinnie SM, Rodriguez-Lopez EM, Vederas JC, Crowther JM, Suzuki H, Dobson RC, Leustek T, Triassi AJ, Wheatley MS, Hudson AO. Differential response of orthologous L,L-diaminopimelate aminotransferases (DapL) to enzyme inhibitory antibiotic lead compounds. Bioorganic & Medicinal Chemistry. 22: 523-30. PMID 24268540 DOI: 10.1016/J.Bmc.2013.10.055 |
0.371 |
|
| 2014 |
Lohans CT, Vederas JC. Structural characterization of thioether-bridged bacteriocins. The Journal of Antibiotics. 67: 23-30. PMID 24022605 DOI: 10.1038/Ja.2013.81 |
0.711 |
|
| 2013 |
Pandya K, Dietrich D, Seibert J, Vederas JC, Odermatt A. Synthesis of sterically encumbered 11β-aminoprogesterone derivatives and evaluation as 11β-hydroxysteroid dehydrogenase inhibitors and mineralocorticoid receptor antagonists. Bioorganic & Medicinal Chemistry. 21: 6274-81. PMID 24074876 DOI: 10.1016/J.Bmc.2013.08.068 |
0.701 |
|
| 2013 |
Lohans CT, Towle KM, Miskolzie M, McKay RT, van Belkum MJ, McMullen LM, Vederas JC. Solution structures of the linear leaderless bacteriocins enterocin 7A and 7B resemble carnocyclin A, a circular antimicrobial peptide. Biochemistry. 52: 3987-94. PMID 23725536 DOI: 10.1021/Bi400359Z |
0.728 |
|
| 2013 |
Gao Z, Wang J, Norquay AK, Qiao K, Tang Y, Vederas JC. Investigation of fungal iterative polyketide synthase functions using partially assembled intermediates. Journal of the American Chemical Society. 135: 1735-8. PMID 23356934 DOI: 10.1021/Ja4001823 |
0.742 |
|
| 2013 |
Towle KM, Chaytor JL, Liu H, Austin P, Roberge M, Roskelley CD, Vederas JC. Synthesis and biological studies of neopetrosiamides as inhibitors of cancer cell invasion. Organic & Biomolecular Chemistry. 11: 1476-81. PMID 23334605 DOI: 10.1039/C3Ob27238A |
0.765 |
|
| 2013 |
Cochrane SA, Huang Z, Vederas JC. Investigation of the ring-closing metathesis of peptides in water. Organic & Biomolecular Chemistry. 11: 630-9. PMID 23212663 DOI: 10.1039/C2Ob26938D |
0.792 |
|
| 2013 |
Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Vederas JC, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports. 30: 108-60. PMID 23165928 DOI: 10.1039/C2Np20085F |
0.798 |
|
| 2013 |
Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Vederas JC, et al. Erratum: Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature (Natural Product Reports (2013) 30 (108-160) DOI:10.1039/C2NP20085F) Natural Product Reports. 30: 1568-1568. DOI: 10.1039/C3Np90040A |
0.784 |
|
| 2012 |
Lohans CT, Huang Z, van Belkum MJ, Giroud M, Sit CS, Steels EM, Zheng J, Whittal RM, McMullen LM, Vederas JC. Structural characterization of the highly cyclized lantibiotic paenicidin A via a partial desulfurization/reduction strategy. Journal of the American Chemical Society. 134: 19540-3. PMID 23167271 DOI: 10.1021/Ja3089229 |
0.812 |
|
| 2012 |
Pyle BW, Tran HT, Pickel B, Haslam TM, Gao Z, MacNevin G, Vederas JC, Kim SU, Ro DK. Enzymatic synthesis of valerena-4,7(11)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana officinalis). The Febs Journal. 279: 3136-46. PMID 22776156 DOI: 10.1111/J.1742-4658.2012.08692.X |
0.731 |
|
| 2012 |
Ames BD, Nguyen C, Bruegger J, Smith P, Xu W, Ma S, Wong E, Wong S, Xie X, Li JW, Vederas JC, Tang Y, Tsai SC. Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 109: 11144-9. PMID 22733743 DOI: 10.1073/Pnas.1113029109 |
0.762 |
|
| 2012 |
Li J, van Belkum MJ, Vederas JC. Functional characterization of recombinant hyoscyamine 6β-hydroxylase from Atropa belladonna. Bioorganic & Medicinal Chemistry. 20: 4356-63. PMID 22705021 DOI: 10.1016/J.Bmc.2012.05.042 |
0.323 |
|
| 2012 |
Lama A, Pané-Farré J, Chon T, Wiersma AM, Sit CS, Vederas JC, Hecker M, Nakano MM. Response of methicillin-resistant Staphylococcus aureus to amicoumacin A. Plos One. 7: e34037. PMID 22479511 DOI: 10.1371/Journal.Pone.0034037 |
0.705 |
|
| 2012 |
Zhou H, Gao Z, Qiao K, Wang J, Vederas JC, Tang Y. A fungal ketoreductase domain that displays substrate-dependent stereospecificity. Nature Chemical Biology. 8: 331-3. PMID 22406519 DOI: 10.1038/Nchembio.912 |
0.711 |
|
| 2012 |
Fan C, Vederas JC. Synthesis and structure-activity relationships of o-sulfonamido-arylhydrazides as inhibitors of LL-diaminopimelate aminotransferase (LL-DAP-AT). Organic & Biomolecular Chemistry. 10: 5815-9. PMID 22371097 DOI: 10.1039/C2Ob00040G |
0.529 |
|
| 2012 |
Dietrich D, van Belkum MJ, Vederas JC. Characterization of DcsC, a PLP-independent racemase involved in the biosynthesis of D-cycloserine. Organic & Biomolecular Chemistry. 10: 2248-54. PMID 22307920 DOI: 10.1039/C2Ob06864H |
0.573 |
|
| 2012 |
Ross AC, McKinnie SM, Vederas JC. The synthesis of active and stable diaminopimelate analogues of the lantibiotic peptide lactocin S. Journal of the American Chemical Society. 134: 2008-11. PMID 22280450 DOI: 10.1021/Ja211088M |
0.636 |
|
| 2012 |
Lohans CT, Vederas JC. Development of Class IIa Bacteriocins as Therapeutic Agents. International Journal of Microbiology. 2012: 386410. PMID 22187559 DOI: 10.1155/2012/386410 |
0.677 |
|
| 2012 |
Sit CS, Lohans CT, van Belkum MJ, Campbell CD, Miskolzie M, Vederas JC. Substitution of a conserved disulfide in the type IIa bacteriocin, leucocin A, with L-leucine and L-serine residues: effects on activity and three-dimensional structure. Chembiochem : a European Journal of Chemical Biology. 13: 35-8. PMID 22121114 DOI: 10.1002/Cbic.201100634 |
0.784 |
|
| 2012 |
Sit C, Lohans C, Belkum Mv, Campbell C, Miskolzie M, Vederas J. C9L,C14L-LeuA Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Ljt/Pdb |
0.746 |
|
| 2012 |
Sit C, Lohans C, Belkum Mv, Campbell C, Miskolzie M, Vederas J. (C9S, C14S)-leucocin A Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr17955 |
0.773 |
|
| 2012 |
McKinnie SMK, Ross AC, Little MJ, Vederas JC. The solid phase supported peptide synthesis of analogues of the lantibiotic lactocin S Medchemcomm. 3: 971-975. DOI: 10.1039/C2Md20014G |
0.605 |
|
| 2011 |
Shaheen M, Li J, Ross AC, Vederas JC, Jensen SE. Paenibacillus polymyxa PKB1 produces variants of polymyxin B-type antibiotics. Chemistry & Biology. 18: 1640-8. PMID 22195566 DOI: 10.1016/J.Chembiol.2011.09.017 |
0.612 |
|
| 2011 |
Liu W, Chan AS, Liu H, Cochrane SA, Vederas JC. Solid supported chemical syntheses of both components of the lantibiotic lacticin 3147. Journal of the American Chemical Society. 133: 14216-9. PMID 21848315 DOI: 10.1021/Ja206017P |
0.796 |
|
| 2011 |
Sit CS, van Belkum MJ, McKay RT, Worobo RW, Vederas JC. The 3D solution structure of thurincin H, a bacteriocin with four sulfur to α-carbon crosslinks. Angewandte Chemie (International Ed. in English). 50: 8718-21. PMID 21786372 DOI: 10.1002/Anie.201102527 |
0.684 |
|
| 2011 |
Watanabe N, Clay MD, van Belkum MJ, Fan C, Vederas JC, James MN. The structure of LL-diaminopimelate aminotransferase from Chlamydia trachomatis: implications for its broad substrate specificity. Journal of Molecular Biology. 411: 649-60. PMID 21722650 DOI: 10.1016/J.Jmb.2011.06.023 |
0.774 |
|
| 2011 |
van Belkum MJ, Martin-Visscher LA, Vederas JC. Structure and genetics of circular bacteriocins. Trends in Microbiology. 19: 411-8. PMID 21664137 DOI: 10.1016/J.Tim.2011.04.004 |
0.788 |
|
| 2011 |
Sit CS, McKay RT, Hill C, Ross RP, Vederas JC. The 3D structure of thuricin CD, a two-component bacteriocin with cysteine sulfur to α-carbon cross-links. Journal of the American Chemical Society. 133: 7680-3. PMID 21526839 DOI: 10.1021/Ja201802F |
0.725 |
|
| 2011 |
Barriuso J, Nguyen DT, Li JW, Roberts JN, MacNevin G, Chaytor JL, Marcus SL, Vederas JC, Ro DK. Double oxidation of the cyclic nonaketide dihydromonacolin L to monacolin J by a single cytochrome P450 monooxygenase, LovA. Journal of the American Chemical Society. 133: 8078-81. PMID 21495633 DOI: 10.1021/Ja201138V |
0.721 |
|
| 2011 |
Liu X, Vederas JC, Whittal RM, Zheng J, Stiles ME, Carlson D, Franz CM, McMullen LM, van Belkum MJ. Identification of an N-terminal formylated, two-peptide bacteriocin from Enterococcus faecalis 710C. Journal of Agricultural and Food Chemistry. 59: 5602-8. PMID 21469734 DOI: 10.1021/Jf104751V |
0.359 |
|
| 2011 |
Sit CS, Yoganathan S, Vederas JC. Biosynthesis of aminovinyl-cysteine-containing peptides and its application in the production of potential drug candidates. Accounts of Chemical Research. 44: 261-8. PMID 21366289 DOI: 10.1021/Ar1001395 |
0.829 |
|
| 2011 |
Yoganathan S, Sit CS, Vederas JC. Chemical synthesis and biological evaluation of gallidermin-siderophore conjugates. Organic & Biomolecular Chemistry. 9: 2133-41. PMID 21290068 DOI: 10.1039/C0Ob00846J |
0.797 |
|
| 2011 |
Martin-Visscher LA, Yoganathan S, Sit CS, Lohans CT, Vederas JC. The activity of bacteriocins from Carnobacterium maltaromaticum UAL307 against gram-negative bacteria in combination with EDTA treatment. Fems Microbiology Letters. 317: 152-9. PMID 21255070 DOI: 10.1111/J.1574-6968.2011.02223.X |
0.792 |
|
| 2011 |
Ross AC, Vederas JC. Fundamental functionality: recent developments in understanding the structure-activity relationships of lantibiotic peptides. The Journal of Antibiotics. 64: 27-34. PMID 21081951 DOI: 10.1038/Ja.2010.136 |
0.609 |
|
| 2010 |
van Belkum MJ, Martin-Visscher LA, Vederas JC. Cloning and Characterization of the Gene Cluster Involved in the Production of the Circular Bacteriocin Carnocyclin A. Probiotics and Antimicrobial Proteins. 2: 218-25. PMID 26781316 DOI: 10.1007/S12602-010-9056-1 |
0.759 |
|
| 2010 |
Zhou H, Qiao K, Gao Z, Vederas JC, Tang Y. Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs. The Journal of Biological Chemistry. 285: 41412-21. PMID 20961859 DOI: 10.1074/Jbc.M110.183574 |
0.737 |
|
| 2010 |
Campbell CD, Vederas JC. Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes. Biopolymers. 93: 755-63. PMID 20577995 DOI: 10.1002/Bip.21428 |
0.323 |
|
| 2010 |
Rea MC, Sit CS, Clayton E, O'Connor PM, Whittal RM, Zheng J, Vederas JC, Ross RP, Hill C. Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile. Proceedings of the National Academy of Sciences of the United States of America. 107: 9352-7. PMID 20435915 DOI: 10.1073/Pnas.0913554107 |
0.724 |
|
| 2010 |
Yamamoto K, Xu J, Kawulka KE, Vederas JC, Ramamoorthy A. Use of a copper-chelated lipid speeds up NMR measurements from membrane proteins. Journal of the American Chemical Society. 132: 6929-31. PMID 20433169 DOI: 10.1021/Ja102103N |
0.783 |
|
| 2010 |
Huang Z, Derksen DJ, Vederas JC. Preparation and use of cysteine orthoesters for solid-supported synthesis of peptides. Organic Letters. 12: 2282-5. PMID 20405951 DOI: 10.1021/Ol100645T |
0.755 |
|
| 2010 |
Zhou H, Qiao K, Gao Z, Meehan MJ, Li JW, Zhao X, Dorrestein PC, Vederas JC, Tang Y. Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis. Journal of the American Chemical Society. 132: 4530-1. PMID 20222707 DOI: 10.1021/Ja100060K |
0.739 |
|
| 2010 |
Fan C, Clay MD, Deyholos MK, Vederas JC. Exploration of inhibitors for diaminopimelate aminotransferase. Bioorganic & Medicinal Chemistry. 18: 2141-51. PMID 20185317 DOI: 10.1016/J.Bmc.2010.02.001 |
0.784 |
|
| 2010 |
Liu H, Boudreau MA, Zheng J, Whittal RM, Austin P, Roskelley CD, Roberge M, Andersen RJ, Vederas JC. Chemical synthesis and biological activity of the neopetrosiamides and their analogues: revision of disulfide bond connectivity. Journal of the American Chemical Society. 132: 1486-7. PMID 20073461 DOI: 10.1021/Ja9102925 |
0.707 |
|
| 2010 |
Ross AC, Liu H, Pattabiraman VR, Vederas JC. Synthesis of the lantibiotic lactocin S using peptide cyclizations on solid phase. Journal of the American Chemical Society. 132: 462-3. PMID 20017553 DOI: 10.1021/Ja9095945 |
0.804 |
|
| 2010 |
van Belkum MJ, Martin-Visscher LA, Vederas JC. Cloning and Characterization of the Gene Cluster Involved in the Production of the Circular Bacteriocin Carnocyclin A Probiotics and Antimicrobial Proteins. 2: 218-225. DOI: 10.1007/s12602-010-9056-1 |
0.725 |
|
| 2010 |
Ramtohul YK, Martin NI, Silkin L, James MNG, Vederas JC. ChemInform Abstract: Synthesis of Pseudoxazolones and Their Inhibition of the 3C Cysteine Proteinases from Hepatitis A Virus and Human Rhinovirus-14. Cheminform. 33: no-no. DOI: 10.1002/chin.200239120 |
0.782 |
|
| 2010 |
Lall MS, Ramtohul YK, James MNG, Vederas JC. ChemInform Abstract: Serine and Threonine β-Lactones: A New Class of Hepatitis A Virus 3C Cysteine Proteinase Inhibitors. Cheminform. 33: no-no. DOI: 10.1002/chin.200236107 |
0.674 |
|
| 2010 |
Yoganathan S, Vederas JC. Nonprotein l-amino acids Comprehensive Natural Products Ii: Chemistry and Biology. 5: 5-70. |
0.618 |
|
| 2009 |
Liu H, Pattabiraman VR, Vederas JC. Synthesis and biological activity of oxa-lacticin A2, a lantibiotic analogue with sulfur replaced by oxygen. Organic Letters. 11: 5574-7. PMID 19921853 DOI: 10.1021/Ol9025205 |
0.737 |
|
| 2009 |
Ma SM, Li JW, Choi JW, Zhou H, Lee KK, Moorthie VA, Xie X, Kealey JT, Da Silva NA, Vederas JC, Tang Y. Complete reconstitution of a highly reducing iterative polyketide synthase. Science (New York, N.Y.). 326: 589-92. PMID 19900898 DOI: 10.1126/Science.1175602 |
0.79 |
|
| 2009 |
Martin-Visscher LA, Gong X, Duszyk M, Vederas JC. The three-dimensional structure of carnocyclin A reveals that many circular bacteriocins share a common structural motif. The Journal of Biological Chemistry. 284: 28674-81. PMID 19692336 DOI: 10.1074/Jbc.M109.036459 |
0.801 |
|
| 2009 |
Huang T, Geng H, Miyyapuram VR, Sit CS, Vederas JC, Nakano MM. Isolation of a variant of subtilosin A with hemolytic activity. Journal of Bacteriology. 191: 5690-6. PMID 19633086 DOI: 10.1128/Jb.00541-09 |
0.71 |
|
| 2009 |
Gong X, Martin-Visscher LA, Nahirney D, Vederas JC, Duszyk M. The circular bacteriocin, carnocyclin A, forms anion-selective channels in lipid bilayers. Biochimica Et Biophysica Acta. 1788: 1797-803. PMID 19463781 DOI: 10.1016/J.Bbamem.2009.05.008 |
0.768 |
|
| 2009 |
Spantulescu MD, Boudreau MA, Vederas JC. Retention of configuration in photolytic decarboxylation of peresters to form chiral acetals and ethers. Organic Letters. 11: 645-8. PMID 19113895 DOI: 10.1021/Ol802745N |
0.582 |
|
| 2009 |
Pillai B, Moorthie VA, van Belkum MJ, Marcus SL, Cherney MM, Diaper CM, Vederas JC, James MN. Crystal structure of diaminopimelate epimerase from Arabidopsis thaliana, an amino acid racemase critical for L-lysine biosynthesis. Journal of Molecular Biology. 385: 580-94. PMID 19013471 DOI: 10.1016/J.Jmb.2008.10.072 |
0.799 |
|
| 2009 |
Martin-Visscher L, Gong X, Duszyk M, Vederas J. The solution structure of the circular bacteriocin carnocyclin A (CclA) Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Kjf/Pdb |
0.744 |
|
| 2008 |
Watanabe N, Clay MD, van Belkum MJ, Cherney MM, Vederas JC, James MN. Mechanism of substrate recognition and PLP-induced conformational changes in LL-diaminopimelate aminotransferase from Arabidopsis thaliana. Journal of Molecular Biology. 384: 1314-29. PMID 18952095 DOI: 10.1016/J.Jmb.2008.10.022 |
0.758 |
|
| 2008 |
Yoganathan S, Vederas JC. Fracturing rings to understand lantibiotics. Chemistry & Biology. 15: 999-1001. PMID 18940660 DOI: 10.1016/J.Chembiol.2008.10.001 |
0.664 |
|
| 2008 |
Pattabiraman VR, McKinnie SM, Vederas JC. Solid-supported synthesis and biological evaluation of the lantibiotic peptide bis(desmethyl) lacticin 3147 A2. Angewandte Chemie (International Ed. in English). 47: 9472-5. PMID 18937239 DOI: 10.1002/Anie.200802919 |
0.694 |
|
| 2008 |
Derksen DJ, Boudreau MA, Vederas JC. Hydrophobic interactions as substitutes for a conserved disulfide linkage in the type IIa bacteriocins, leucocin A and pediocin PA-1. Chembiochem : a European Journal of Chemical Biology. 9: 1898-901. PMID 18642256 DOI: 10.1002/Cbic.200800272 |
0.679 |
|
| 2008 |
Martin-Visscher LA, van Belkum MJ, Garneau-Tsodikova S, Whittal RM, Zheng J, McMullen LM, Vederas JC. Isolation and characterization of carnocyclin a, a novel circular bacteriocin produced by Carnobacterium maltaromaticum UAL307. Applied and Environmental Microbiology. 74: 4756-63. PMID 18552180 DOI: 10.1128/Aem.00817-08 |
0.806 |
|
| 2008 |
Martin-Visscher LA, Sprules T, Gursky LJ, Vederas JC. Nuclear magnetic resonance solution structure of PisI, a group B immunity protein that provides protection against the type IIa bacteriocin piscicolin 126, PisA. Biochemistry. 47: 6427-36. PMID 18500825 DOI: 10.1021/Bi8004076 |
0.777 |
|
| 2008 |
Sit CS, Vederas JC. Approaches to the discovery of new antibacterial agents based on bacteriocins. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 86: 116-23. PMID 18443625 DOI: 10.1139/O07-153 |
0.724 |
|
| 2008 |
Huitema C, Zhang J, Yin J, James MN, Vederas JC, Eltis LD. Heteroaromatic ester inhibitors of hepatitis A virus 3C proteinase: Evaluation of mode of action. Bioorganic & Medicinal Chemistry. 16: 5761-77. PMID 18407505 DOI: 10.1016/J.Bmc.2008.03.059 |
0.38 |
|
| 2008 |
Zhang J, Huitema C, Niu C, Yin J, James MN, Eltis LD, Vederas JC. Aryl methylene ketones and fluorinated methylene ketones as reversible inhibitors for severe acute respiratory syndrome (SARS) 3C-like proteinase. Bioorganic Chemistry. 36: 229-40. PMID 18295820 DOI: 10.1016/J.Bioorg.2008.01.001 |
0.349 |
|
| 2008 |
Silkin L, Hamza S, Kaufman S, Cobb SL, Vederas JC. Spermicidal bacteriocins: lacticin 3147 and subtilosin A. Bioorganic & Medicinal Chemistry Letters. 18: 3103-6. PMID 18042385 DOI: 10.1016/J.Bmcl.2007.11.024 |
0.789 |
|
| 2008 |
Niu C, Yin J, Zhang J, Vederas JC, James MN. Molecular docking identifies the binding of 3-chloropyridine moieties specifically to the S1 pocket of SARS-CoV Mpro. Bioorganic & Medicinal Chemistry. 16: 293-302. PMID 17931870 DOI: 10.1016/J.Bmc.2007.09.034 |
0.322 |
|
| 2008 |
Martin-Visscher L, Sprules T, Gursky L, Vederas J. NMR solution structure of PisI Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2K19/Pdb |
0.766 |
|
| 2008 |
Watanabe N, Cherney M, van Belkum M, Marcus S, Flegel M, Clay M, Deyholos M, Vederas J, James M. Mechanism of stereospecific substrate recognition by LL-diaminopimelate aminotransferase Acta Crystallographica Section a Foundations of Crystallography. 64: C250-C250. DOI: 10.1107/S0108767308091964 |
0.766 |
|
| 2008 |
Pattabiraman V, McKinnie S, Vederas J. Cover Picture: Solid-Supported Synthesis and Biological Evaluation of the Lantibiotic Peptide Bis(desmethyl) Lacticin 3147 A2 (Angew. Chem. Int. Ed. 49/2008) Angewandte Chemie International Edition. 47: 9357-9357. DOI: 10.1002/Anie.200890251 |
0.694 |
|
| 2008 |
Pattabiraman V, McKinnie S, Vederas J. Titelbild: Solid-Supported Synthesis and Biological Evaluation of the Lantibiotic Peptide Bis(desmethyl) Lacticin 3147 A2 (Angew. Chem. 49/2008) Angewandte Chemie. 120: 9497-9497. DOI: 10.1002/Ange.200890300 |
0.694 |
|
| 2007 |
van Belkum MJ, Derksen DJ, Franz CM, Vederas JC. Structure function relationship of inducer peptide pheromones involved in bacteriocin production in Carnobacterium maltaromaticum and Enterococcus faecium. Microbiology (Reading, England). 153: 3660-6. PMID 17975073 DOI: 10.1099/Mic.0.2007/009183-0 |
0.645 |
|
| 2007 |
Pillai B, Cherney M, Diaper CM, Sutherland A, Blanchard JS, Vederas JC, James MN. Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase. Biochemical and Biophysical Research Communications. 363: 547-53. PMID 17889830 DOI: 10.1016/J.Bbrc.2007.09.012 |
0.697 |
|
| 2007 |
Liu H, Pattabiraman VR, Vederas JC. Stereoselective syntheses of 4-oxa diaminopimelic acid and its protected derivatives via aziridine ring opening. Organic Letters. 9: 4211-4. PMID 17850092 DOI: 10.1021/Ol701742X |
0.755 |
|
| 2007 |
Yin J, Niu C, Cherney MM, Zhang J, Huitema C, Eltis LD, Vederas JC, James MN. A mechanistic view of enzyme inhibition and peptide hydrolysis in the active site of the SARS-CoV 3C-like peptidase. Journal of Molecular Biology. 371: 1060-74. PMID 17599357 DOI: 10.1016/J.Jmb.2007.06.001 |
0.425 |
|
| 2007 |
Watanabe N, Cherney MM, van Belkum MJ, Marcus SL, Flegel MD, Clay MD, Deyholos MK, Vederas JC, James MN. Crystal structure of LL-diaminopimelate aminotransferase from Arabidopsis thaliana: a recently discovered enzyme in the biosynthesis of L-lysine by plants and Chlamydia. Journal of Molecular Biology. 371: 685-702. PMID 17583737 DOI: 10.1016/J.Jmb.2007.05.061 |
0.808 |
|
| 2007 |
Zhang J, Pettersson HI, Huitema C, Niu C, Yin J, James MN, Eltis LD, Vederas JC. Design, synthesis, and evaluation of inhibitors for severe acute respiratory syndrome 3C-like protease based on phthalhydrazide ketones or heteroaromatic esters. Journal of Medicinal Chemistry. 50: 1850-64. PMID 17381079 DOI: 10.1021/Jm061425K |
0.575 |
|
| 2007 |
Cobb SL, Vederas JC. A concise stereoselective synthesis of orthogonally protected lanthionine and beta-methyllanthionine. Organic & Biomolecular Chemistry. 5: 1031-8. PMID 17377656 DOI: 10.1039/B618178C |
0.321 |
|
| 2007 |
Pattabiraman VR, Stymiest JL, Derksen DJ, Martin NI, Vederas JC. Multiple on-resin olefin metathesis to form ring-expanded analogues of the lantibiotic peptide, lacticin 3147 A2. Organic Letters. 9: 699-702. PMID 17286377 DOI: 10.1021/Ol063133J |
0.802 |
|
| 2007 |
Boudreau MA, Vederas JC. Synthesis and biological evaluation of nucleoside dicarboxylates as potential mimics of nucleoside diphosphates. Organic & Biomolecular Chemistry. 5: 627-35. PMID 17285171 DOI: 10.1039/B615230A |
0.597 |
|
| 2007 |
Burr DA, Chen XB, Vederas JC. Syntheses of conjugated pyrones for the enzymatic assay of lovastatin nonaketide synthase, an iterative polyketide synthase. Organic Letters. 9: 161-4. PMID 17192110 DOI: 10.1021/Ol062763I |
0.587 |
|
| 2007 |
Pattabiraman VR, Stymiest JL, Derksen DJ, Martin NI, Vederas JC. On-Resin Olefin Metathesis Synfacts. 2007: 663-663. DOI: 10.1055/S-2007-968531 |
0.533 |
|
| 2006 |
Derksen DJ, Stymiest JL, Vederas JC. Antimicrobial leucocin analogues with a disulfide bridge replaced by a carbocycle or by noncovalent interactions of allyl glycine residues. Journal of the American Chemical Society. 128: 14252-3. PMID 17076487 DOI: 10.1021/Ja066203Q |
0.816 |
|
| 2006 |
Bushman BS, Scholte AA, Cornish K, Scott DJ, Brichta JL, Vederas JC, Ochoa O, Michelmore RW, Shintani DK, Knapp SJ. Identification and comparison of natural rubber from two Lactuca species. Phytochemistry. 67: 2590-6. PMID 17055543 DOI: 10.1016/J.Phytochem.2006.09.012 |
0.542 |
|
| 2006 |
Gursky LJ, Martin NI, Derksen DJ, van Belkum MJ, Kaur K, Vederas JC, Stiles ME, McMullen LM. Production of piscicolin 126 by Carnobacterium maltaromaticum UAL26 is controlled by temperature and induction peptide concentration. Archives of Microbiology. 186: 317-25. PMID 16927067 DOI: 10.1007/S00203-006-0147-Z |
0.8 |
|
| 2006 |
Yin J, Cherney MM, Bergmann EM, Zhang J, Huitema C, Pettersson H, Eltis LD, Vederas JC, James MN. An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors. Journal of Molecular Biology. 361: 673-86. PMID 16860823 DOI: 10.1016/J.Jmb.2006.06.047 |
0.62 |
|
| 2006 |
Pillai B, Cherney MM, Diaper CM, Sutherland A, Blanchard JS, Vederas JC, James MN. Structural insights into stereochemical inversion by diaminopimelate epimerase: an antibacterial drug target. Proceedings of the National Academy of Sciences of the United States of America. 103: 8668-73. PMID 16723397 DOI: 10.1073/Pnas.0602537103 |
0.688 |
|
| 2006 |
Scholte AA, Vederas JC. Incorporation of deuterium-labelled analogs of isopentenyl diphosphate for the elucidation of the stereochemistry of rubber biosynthesis. Organic & Biomolecular Chemistry. 4: 730-42. PMID 16467948 DOI: 10.1039/B515750A |
0.591 |
|
| 2006 |
Vederas JC. 2005 Alfred Bader Award Lecture Diaminopimelate and lysine biosynthesis - An antimicrobial target in bacteria Canadian Journal of Chemistry. 84: 1197-1207. DOI: 10.1139/V06-072 |
0.373 |
|
| 2006 |
Pollard MM, Vederas JC. A convenient preparation of thioether functionalized porphyrins Tetrahedron. 62: 11908-11915. DOI: 10.1016/J.Tet.2006.09.091 |
0.634 |
|
| 2005 |
Diaper CM, Sutherland A, Pillai B, James MN, Semchuk P, Blanchard JS, Vederas JC. The stereoselective synthesis of aziridine analogues of diaminopimelic acid (DAP) and their interaction with dap epimerase. Organic & Biomolecular Chemistry. 3: 4402-11. PMID 16327902 DOI: 10.1039/B513409A |
0.657 |
|
| 2005 |
Yin J, Bergmann EM, Cherney MM, Lall MS, Jain RP, Vederas JC, James MN. Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site. Journal of Molecular Biology. 354: 854-71. PMID 16288920 DOI: 10.1016/J.Jmb.2005.09.074 |
0.807 |
|
| 2005 |
Stymiest JL, Mitchell BF, Wong S, Vederas JC. Synthesis of oxytocin analogues with replacement of sulfur by carbon gives potent antagonists with increased stability. The Journal of Organic Chemistry. 70: 7799-809. PMID 16277299 DOI: 10.1021/Jo050539L |
0.803 |
|
| 2005 |
Thennarasu S, Lee DK, Poon A, Kawulka KE, Vederas JC, Ramamoorthy A. Membrane permeabilization, orientation, and antimicrobial mechanism of subtilosin A. Chemistry and Physics of Lipids. 137: 38-51. PMID 16095584 DOI: 10.1016/J.Chemphyslip.2005.06.003 |
0.789 |
|
| 2005 |
Yin J, Bergmann EM, Cherney MM, Lall MS, Jain RP, Vederas JC, James MNG. Crystal structure of HAV 3C protease complexed with a β-lactone inhibitor: a new crystal form of HAV 3C and its application for studying enzyme-inhibitor interaction Acta Crystallographica Section a Foundations of Crystallography. 61: c206-c206. DOI: 10.1107/S0108767305091233 |
0.701 |
|
| 2004 |
Jain RP, Pettersson HI, Zhang J, Aull KD, Fortin PD, Huitema C, Eltis LD, Parrish JC, James MN, Wishart DS, Vederas JC. Synthesis and evaluation of keto-glutamine analogues as potent inhibitors of severe acute respiratory syndrome 3CLpro. Journal of Medicinal Chemistry. 47: 6113-6. PMID 15566280 DOI: 10.1021/Jm0494873 |
0.606 |
|
| 2004 |
Garneau S, Qiao L, Chen L, Walker S, Vederas JC. Synthesis of mono- and disaccharide analogs of moenomycin and lipid II for inhibition of transglycosylase activity of penicillin-binding protein 1b. Bioorganic & Medicinal Chemistry. 12: 6473-94. PMID 15556765 DOI: 10.1016/J.Bmc.2004.09.019 |
0.54 |
|
| 2004 |
Sprules T, Kawulka KE, Vederas JC. NMR solution structure of ImB2, a protein conferring immunity to antimicrobial activity of the type IIa bacteriocin, carnobacteriocin B2. Biochemistry. 43: 11740-9. PMID 15362858 DOI: 10.1021/Bi048854+ |
0.801 |
|
| 2004 |
Lall MS, Jain RP, Vederas JC. Inhibitors of 3C cysteine proteinases from Picornaviridae. Current Topics in Medicinal Chemistry. 4: 1239-53. PMID 15320724 DOI: 10.2174/1568026043387836 |
0.803 |
|
| 2004 |
Kaur K, Andrew LC, Wishart DS, Vederas JC. Dynamic relationships among type IIa bacteriocins: temperature effects on antimicrobial activity and on structure of the C-terminal amphipathic alpha helix as a receptor-binding region. Biochemistry. 43: 9009-20. PMID 15248758 DOI: 10.1021/Bi036018E |
0.414 |
|
| 2004 |
Jain RP, Vederas JC. Structural variations in keto-glutamines for improved inhibition against hepatitis A virus 3C proteinase. Bioorganic & Medicinal Chemistry Letters. 14: 3655-8. PMID 15203137 DOI: 10.1016/J.Bmcl.2004.05.021 |
0.345 |
|
| 2004 |
Sprules T, Kawulka KE, Gibbs AC, Wishart DS, Vederas JC. NMR solution structure of the precursor for carnobacteriocin B2, an antimicrobial peptide from Carnobacterium piscicola. European Journal of Biochemistry / Febs. 271: 1748-56. PMID 15096213 DOI: 10.1111/J.1432-1033.2004.04085.X |
0.823 |
|
| 2004 |
Kawulka KE, Sprules T, Diaper CM, Whittal RM, McKay RT, Mercier P, Zuber P, Vederas JC. Structure of subtilosin A, a cyclic antimicrobial peptide from Bacillus subtilis with unusual sulfur to alpha-carbon cross-links: formation and reduction of alpha-thio-alpha-amino acid derivatives. Biochemistry. 43: 3385-95. PMID 15035610 DOI: 10.1021/Bi0359527 |
0.808 |
|
| 2004 |
Martin NI, Sprules T, Carpenter MR, Cotter PD, Hill C, Ross RP, Vederas JC. Structural characterization of lacticin 3147, a two-peptide lantibiotic with synergistic activity. Biochemistry. 43: 3049-56. PMID 15023056 DOI: 10.1021/Bi0362065 |
0.653 |
|
| 2004 |
Scholte AA, Eubanks LM, Poulter CD, Vederas JC. Synthesis and biological activity of isopentenyl diphosphate analogues. Bioorganic & Medicinal Chemistry. 12: 763-70. PMID 14759736 DOI: 10.1016/J.Bmc.2003.11.033 |
0.626 |
|
| 2003 |
Jain RP, Vederas JC. Synthesis of beta-cyclopropylalanines by photolysis of diacyl peroxides. Organic Letters. 5: 4669-72. PMID 14627411 DOI: 10.1021/Ol035859A |
0.305 |
|
| 2003 |
Mau CJ, Garneau S, Scholte AA, Van Fleet JE, Vederas JC, Cornish K. Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase. European Journal of Biochemistry / Febs. 270: 3939-45. PMID 14511375 DOI: 10.1046/J.1432-1033.2003.03775.X |
0.607 |
|
| 2003 |
Sorensen JL, Auclair K, Kennedy J, Hutchinson CR, Vederas JC. Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes. Organic & Biomolecular Chemistry. 1: 50-9. PMID 12929390 DOI: 10.1039/B207721C |
0.712 |
|
| 2003 |
Spantulescu MD, Jain RP, Derksen DJ, Vederas JC. Photolysis of diacyl peroxides: a radical-based approach for the synthesis of functionalized amino acids. Organic Letters. 5: 2963-5. PMID 12889919 DOI: 10.1021/ol035125y |
0.554 |
|
| 2003 |
Sorensen JL, Vederas JC. Monacolin N, a compound resulting from derailment of type I iterative polyketide synthase function en route to lovastatin. Chemical Communications (Cambridge, England). 1492-3. PMID 12868719 DOI: 10.1039/B304252A |
0.538 |
|
| 2003 |
Kawulka K, Sprules T, McKay RT, Mercier P, Diaper CM, Zuber P, Vederas JC. Structure of subtilosin A, an antimicrobial peptide from Bacillus subtilis with unusual posttranslational modifications linking cysteine sulfurs to alpha-carbons of phenylalanine and threonine. Journal of the American Chemical Society. 125: 4726-7. PMID 12696888 DOI: 10.1021/Ja029654T |
0.809 |
|
| 2003 |
Garneau S, Ference CA, van Belkum MJ, Stiles ME, Vederas JC. Purification and characterization of brochocin A and brochocin B(10-43), a functional fragment generated by heterologous expression in Carnobacterium piscicola. Applied and Environmental Microbiology. 69: 1352-8. PMID 12620816 DOI: 10.1128/Aem.69.3.1352-1358.2003 |
0.409 |
|
| 2003 |
Martin NI, Hu H, Moake MM, Churey JJ, Whittal R, Worobo RW, Vederas JC. Isolation, structural characterization, and properties of mattacin (polymyxin M), a cyclic peptide antibiotic produced by Paenibacillus kobensis M. The Journal of Biological Chemistry. 278: 13124-32. PMID 12569104 DOI: 10.1074/Jbc.M212364200 |
0.652 |
|
| 2003 |
Stymiest JL, Mitchell BF, Wong S, Vederas JC. Synthesis of biologically active dicarba analogues of the peptide hormone oxytocin using ring-closing metathesis. Organic Letters. 5: 47-9. PMID 12509887 DOI: 10.1021/Ol027160V |
0.798 |
|
| 2002 |
Garneau S, Martin NI, Vederas JC. Two-peptide bacteriocins produced by lactic acid bacteria. Biochimie. 84: 577-92. PMID 12423802 DOI: 10.1016/S0300-9084(02)01414-1 |
0.654 |
|
| 2002 |
Sutherland A, Vederas JC. Conjugate addition of radicals generated from diacyloxyiodobenzenes to dehydroamino acid derivatives; a synthesis of diaminopimelic acid analogues. Chemical Communications (Cambridge, England). 224-5. PMID 12120376 DOI: 10.1039/B109343F |
0.312 |
|
| 2002 |
Ramtohul YK, James MN, Vederas JC. Synthesis and evaluation of keto-glutamine analogues as inhibitors of hepatitis A virus 3C proteinase. The Journal of Organic Chemistry. 67: 3169-78. PMID 12003522 DOI: 10.1021/Jo0157831 |
0.767 |
|
| 2002 |
Lall MS, Ramtohul YK, James MN, Vederas JC. Serine and threonine beta-lactones: a new class of hepatitis A virus 3C cysteine proteinase inhibitors. The Journal of Organic Chemistry. 67: 1536-47. PMID 11871884 DOI: 10.1021/Jo0109016 |
0.785 |
|
| 2002 |
Ramtohul YK, Martin NI, Silkin L, James MNG, Vederas JC. Synthesis of pseudoxazolones and their inhibition of the 3C cysteine proteinases from hepatitis A virus and human rhinovirus-14 Journal of the Chemical Society-Perkin Transactions 1. 1351-1359. DOI: 10.1039/B202643K |
0.795 |
|
| 2002 |
Ramtohul YK, Martin NI, Silkin L, James MNG, Vederas JC. Synthesis of pseudoxazolones and their inhibition of the 3C cysteine proteinases from hepatitis A virus and human rhinovirus-14 Journal of the Chemical Society. Perkin Transactions 1. 1351-1359. |
0.777 |
|
| 2001 |
Auclair K, Kennedy J, Hutchinson CR, Vederas JC. Conversion of cyclic nonaketides to lovastatin and compactin by a lovC deficient mutant of Aspergillus terreus. Bioorganic & Medicinal Chemistry Letters. 11: 1527-31. PMID 11412974 DOI: 10.1016/S0960-894X(01)00290-6 |
0.62 |
|
| 2001 |
Sutherland A, Auclair K, Vederas JC. Recent advances in the biosynthetic studies of lovastatin. Current Opinion in Drug Discovery & Development. 4: 229-36. PMID 11378962 |
0.591 |
|
| 2001 |
Ramtohul YK, Martin NI, Silkin L, James MNG, Vederas JC. Pseudoxazolones, a new class of inhibitors for cysteine proteinases: inhibition of hepatitis A virus and human rhinovirus 3C proteinases Chemical Communications. 2740-2741. DOI: 10.1039/B109095J |
0.779 |
|
| 2001 |
Caplan JF, Sutherland A, Vederas JC. The first stereospecific synthesis of L-tetrahydrodipicolinic acid; a key intermediate of diaminopimelate metabolism Journal of the Chemical Society. Perkin Transactions 1. 2217-2220. DOI: 10.1039/B105091P |
0.789 |
|
| 2001 |
Ramtohul YK, Martin NI, Silkin L, James MNG, Vederas JC. Pseudoxazolones, a new class of inhibitors for cysteine proteinases: Inhibition of hepatitis A virus and human rhinovirus 3C proteinases Chemical Communications. 2740-2741. |
0.776 |
|
| 2000 |
Hutchinson CR, Kennedy J, Park C, Kendrew S, Auclair K, Vederas J. Aspects of the biosynthesis of non-aromatic fungal polyketides by iterative polyketide synthases. Antonie Van Leeuwenhoek. 78: 287-95. PMID 11386351 DOI: 10.1023/A:1010294330190 |
0.619 |
|
| 2000 |
Cirilli M, Scapin G, Sutherland A, Vederas JC, Blanchard JS. The three-dimensional structure of the ternary complex of Corynebacterium glutamicum diaminopimelate dehydrogenase-NADPH-L-2-amino-6-methylene-pimelate. Protein Science : a Publication of the Protein Society. 9: 2034-7. PMID 11106178 DOI: 10.1110/Ps.9.10.2034 |
0.372 |
|
| 2000 |
Caplan JF, Zheng R, Blanchard JS, Vederas JC. Vinylogous amide analogues of diaminopimelic acid (DAP) as inhibitors of enzymes involved in bacterial lysine biosynthesis. Organic Letters. 2: 3857-60. PMID 11101437 DOI: 10.1021/Ol000271E |
0.793 |
|
| 2000 |
Yan LZ, Gibbs AC, Stiles ME, Wishart DS, Vederas JC. Analogues of bacteriocins: antimicrobial specificity and interactions of leucocin A with its enantiomer, carnobacteriocin B2, and truncated derivatives. Journal of Medicinal Chemistry. 43: 4579-81. PMID 11101349 DOI: 10.1021/Jm000416N |
0.476 |
|
| 2000 |
DeBlassio JL, deLong MA, Glufke U, Kulathila R, Merkler KA, Vederas JC, Merkler DJ. Amidation of salicyluric acid and gentisuric acid: a possible role for peptidylglycine alpha-amidating monooxygenase in the metabolism of aspirin. Archives of Biochemistry and Biophysics. 383: 46-55. PMID 11097175 DOI: 10.1006/Abbi.2000.2047 |
0.342 |
|
| 2000 |
King L, Barnes S, Glufke U, Henz ME, Kirk M, Merkler KA, Vederas JC, Wilcox BJ, Merkler DJ. The enzymatic formation of novel bile acid primary amides. Archives of Biochemistry and Biophysics. 374: 107-17. PMID 10666288 DOI: 10.1006/Abbi.1999.1611 |
0.384 |
|
| 2000 |
Auclair K, Sutherland A, Kennedy J, Witter DJ, Van den Heever JP, Hutchinson CR, Vederas JC. Lovastatin nonaketide synthase catalyzes an intramolecular diels - Alder reaction of a substrate analogue [7] Journal of the American Chemical Society. 122: 11519-11520. DOI: 10.1021/Ja003216+ |
0.602 |
|
| 1999 |
Lall MS, Karvellas C, Vederas JC. β-Lactones as a new class of cysteine proteinase inhibitors: inhibition of hepatitis A virus 3C proteinase by N-Cbz-serine β-Lactone Organic Letters. 1: 803-806. PMID 10823207 DOI: 10.1021/Ol990148R |
0.714 |
|
| 1999 |
Bergmann EM, Cherney MM, Mckendrick J, Frormann S, Luo C, Malcolm BA, Vederas JC, James MN. Crystal structure of an inhibitor complex of the 3C proteinase from hepatitis A virus (HAV) and implications for the polyprotein processing in HAV. Virology. 265: 153-63. PMID 10603326 DOI: 10.1006/Viro.1999.9968 |
0.362 |
|
| 1999 |
Zheng G, Yan LZ, Vederas JC, Zuber P. Genes of the sbo-alb locus of Bacillus subtilis are required for production of the antilisterial bacteriocin subtilosin. Journal of Bacteriology. 181: 7346-55. PMID 10572140 DOI: 10.1128/Jb.181.23.7346-7355.1999 |
0.507 |
|
| 1999 |
Wang Y, Henz ME, Gallagher NL, Chai S, Gibbs AC, Yan LZ, Stiles ME, Wishart DS, Vederas JC. Solution structure of carnobacteriocin B2 and implications for structure-activity relationships among type IIa bacteriocins from lactic acid bacteria. Biochemistry. 38: 15438-47. PMID 10569926 DOI: 10.1021/Bi991351X |
0.542 |
|
| 1999 |
Huang Y, Malcolm BA, Vederas JC. Synthesis and testing of azaglutamine derivatives as inhibitors of hepatitis A virus (HAV) 3C proteinase. Bioorganic & Medicinal Chemistry. 7: 607-19. PMID 10353640 DOI: 10.1016/S0968-0896(99)00006-1 |
0.383 |
|
| 1999 |
Kennedy J, Auclair K, Kendrew SG, Park C, Vederas JC, Hutchinson CR. Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis. Science (New York, N.Y.). 284: 1368-72. PMID 10334994 DOI: 10.1126/Science.284.5418.1368 |
0.647 |
|
| 1999 |
Simpson TJ, R. Hanson J, B. Herbert R, Robins DJ, Vederas JC, Schofield CJ, Mann J. Book Reviews: : Comprehensive Natural Products Chemistry. Volumes 1 to 8. Natural Product Reports. 16: 637. DOI: 10.1039/A905Bkry |
0.391 |
|
| 1999 |
Sutherland A, Caplan JF, Vederas JC. Unsaturated α-aminopimelic acids as potent inhibitors of meso-diaminopimelic acid (DAP) D-dehydrogenase Chemical Communications. 555-556. DOI: 10.1039/A900297I |
0.788 |
|
| 1999 |
Hill RD, Vederas JC. Azodicarboxamides: A new class of cysteine proteinase inhibitor for hepatitis A virus and human rhinovirus 3C enzymes Journal of Organic Chemistry. 64: 9538-9546. DOI: 10.1021/Jo9915123 |
0.355 |
|
| 1998 |
McCormick JK, Poon A, Sailer M, Gao Y, Roy KL, McMullen LM, Vederas JC, Stiles ME, Van Belkum MJ. Genetic characterization and heterologous expression of brochocin-C, an antibotulinal, two-peptide bacteriocin produced by Brochothrix campestris ATCC 43754. Applied and Environmental Microbiology. 64: 4757-66. PMID 9835559 DOI: 10.1128/Aem.64.12.4757-4766.1998 |
0.424 |
|
| 1998 |
Scapin G, Cirilli M, Reddy SG, Gao Y, Vederas JC, Blanchard JS. Substrate and inhibitor binding sites in Corynebacterium glutamicum diaminopimelate dehydrogenase. Biochemistry. 37: 3278-85. PMID 9521647 DOI: 10.1021/Bi9727949 |
0.375 |
|
| 1998 |
Gao Y, Lane-Bell P, Vederas JC. Stereoselective synthesis of meso-2,6-diaminopimelic acid and its selectively protected derivatives Journal of Organic Chemistry. 63: 2133-2143. DOI: 10.1021/Jo972133H |
0.32 |
|
| 1997 |
Fregeau Gallagher NL, Sailer M, Niemczura WP, Nakashima TT, Stiles ME, Vederas JC. Three-dimensional structure of leucocin A in trifluoroethanol and dodecylphosphocholine micelles: spatial location of residues critical for biological activity in type IIa bacteriocins from lactic acid bacteria. Biochemistry. 36: 15062-72. PMID 9398233 DOI: 10.1021/Bi971263H |
0.374 |
|
| 1997 |
Morris TS, Frormann S, Shechosky S, Lowe C, Lall MS, Gauss-Müller V, Purcell RH, Emerson SU, Vederas JC, Malcolm BA. In vitro and ex vivo inhibition of hepatitis A virus 3C proteinase by a peptidyl monofluoromethyl ketone. Bioorganic & Medicinal Chemistry. 5: 797-807. PMID 9208091 DOI: 10.1016/S0968-0896(97)88649-X |
0.812 |
|
| 1997 |
Quadri LE, Yan LZ, Stiles ME, Vederas JC. Effect of amino acid substitutions on the activity of carnobacteriocin B2. Overproduction of the antimicrobial peptide, its engineered variants, and its precursor in Escherichia coli. The Journal of Biological Chemistry. 272: 3384-8. PMID 9013580 DOI: 10.1074/Jbc.272.6.3384 |
0.568 |
|
| 1997 |
Andrews MD, O'Callaghan KA, Vederas JC. Synthesis of tripeptide inhibitors of peptidylglycine α-amidating monooxygenase (PAM) containing D- and L-styrylglycine Tetrahedron. 53: 8295-8306. DOI: 10.1016/S0040-4020(97)00520-6 |
0.317 |
|
| 1996 |
Auger G, van Heijenoort J, Vederas JC, Blanot D. Effect of analogues of diaminopimelic acid on the meso-diaminopimelate-adding enzyme from Escherichia coli. Febs Letters. 391: 171-4. PMID 8706910 DOI: 10.1016/0014-5793(96)00619-9 |
0.346 |
|
| 1996 |
Harris JM, McDonald R, Vederas JC. Synthesis of a chiral azodicarboxamide containing a bridging binaphthyl moiety: electrophilic amination reactions of achiral ester enolates Journal of the Chemical Society-Perkin Transactions 1. 2669-2674. DOI: 10.1039/P19960002669 |
0.302 |
|
| 1996 |
Cox RJ, Sherwin WA, Lam LKP, Vederas JC. Synthesis and evaluation of novel substrates and inhibitors of N-succinyl-LL-diaminopimelate aminotransferase (DAP-AT) from Escherichia coli Journal of the American Chemical Society. 118: 7449-7460. DOI: 10.1021/Ja960640V |
0.379 |
|
| 1995 |
Quadri LE, Sailer M, Terebiznik MR, Roy KL, Vederas JC, Stiles ME. Characterization of the protein conferring immunity to the antimicrobial peptide carnobacteriocin B2 and expression of carnobacteriocins B2 and BM1. Journal of Bacteriology. 177: 1144-51. PMID 7868585 DOI: 10.1128/Jb.177.5.1144-1151.1995 |
0.3 |
|
| 1995 |
Malcolm BA, Lowe C, Shechosky S, McKay RT, Yang CC, Shah VJ, Simon RJ, Vederas JC, Santi DV. Peptide aldehyde inhibitors of hepatitis A virus 3C proteinase. Biochemistry. 34: 8172-9. PMID 7794931 DOI: 10.1021/Bi00025A024 |
0.406 |
|
| 1995 |
Worobo RW, Van Belkum MJ, Sailer M, Roy KL, Vederas JC, Stiles ME. A signal peptide secretion-dependent bacteriocin from Carnobacterium divergens. Journal of Bacteriology. 177: 3143-9. PMID 7768812 DOI: 10.1128/Jb.177.11.3143-3149.1995 |
0.401 |
|
| 1994 |
Zabriskie TM, Klinge M, Szymanski CM, Cheng H, Vederas JC. Peptide amidation in an invertebrate: purification, characterization, and inhibition of peptidylglycine alpha-hydroxylating monooxygenase from the heads of honeybees (Apis mellifera). Archives of Insect Biochemistry and Physiology. 26: 27-48. PMID 8054657 DOI: 10.1002/Arch.940260104 |
0.37 |
|
| 1994 |
Worobo RW, Henkel T, Sailer M, Roy KL, Vederas JC, Stiles ME. Characteristics and genetic determinant of a hydrophobic peptide bacteriocin, carnobacteriocin A, produced by Carnobacterium piscicola LV17A. Microbiology (Reading, England). 140: 517-26. PMID 8012574 DOI: 10.1099/00221287-140-3-517 |
0.361 |
|
| 1994 |
Klinge M, Cheng H, Zabriskie TM, Vederas JC. Irreversible inhibition of mammalian and insect peptidylglycine α-hydroxylating monooxygenases (PHMS), peptide amidating enzymes, by N-formyl amides Journal of the Chemical Society, Chemical Communications. 1379-1380. DOI: 10.1039/C39940001379 |
0.351 |
|
| 1994 |
Song Y, Niederer D, Lane-Bell PM, Lam LKP, Crawley S, Palcic MM, Pickard MA, Pruess DL, Vederas JC. Stereospecific synthesis of phosphonate analogues of diaminopimelic acid (DAP), their interaction with DAP enzymes, and antibacterial activity of peptide derivatives Journal of Organic Chemistry. 59: 5784-5793. DOI: 10.1021/Jo00098A045 |
0.355 |
|
| 1994 |
Pu Y, Lowe C, Sailer M, Vederas JC. Synthesis, Stability, and Antimicrobial Activity of (+)-Obafluorin and Related .beta.-Lactone Antibiotics Journal of Organic Chemistry. 59: 3642-3655. DOI: 10.1021/Jo00092A025 |
0.341 |
|
| 1994 |
Abbott SD, Lane-Bell P, Sidhu KPS, Vederas JC. Synthesis and testing of heterocyclic analogues of diaminopimelic acid (DAP) as inhibitors of DAP dehydrogenase and DAP epimerase Journal of the American Chemical Society. 116: 6513-6520. DOI: 10.1021/Ja00094A004 |
0.317 |
|
| 1993 |
Sailer M, Helms GL, Henkel T, Niemczura WP, Stiles ME, Vederas JC. 15N- and 13C-labeled media from Anabaena sp. for universal isotopic labeling of bacteriocins: NMR resonance assignments of leucocin A from Leuconostoc gelidum and nisin A from Lactococcus lactis. Biochemistry. 32: 310-8. PMID 8418850 DOI: 10.1021/Bi00052A039 |
0.342 |
|
| 1993 |
Qiao L, Vederas JC. Synthesis of a C-phosphonate disaccharide as a potential inhibitor of peptidoglycan polymerization by transglycosylase The Journal of Organic Chemistry. 58: 3480-3482. DOI: 10.1021/Jo00065A004 |
0.386 |
|
| 1993 |
Niederer DA, Kapron JT, Vederas JC. Amination with N-benzyloxycarbonyl-3-phenyloxaziridine as a route to sensitive chiral α-hydrazino acids: Synthesis of l-hydrazino serine Tetrahedron Letters. 34: 6859-6862. DOI: 10.1016/S0040-4039(00)91814-8 |
0.319 |
|
| 1992 |
Zabriskie TM, Cheng H, Vederas JC. Mechanism-based inactivation of peptidylglycine .alpha.-hydroxylating monooxygenase (PHM) by a substrate analog, D-phenylalanyl-L-phenylalanyl-D-vinylglycine: inhibition of formation of peptide C-terminal amides Journal of the American Chemical Society. 114: 2270-2272. DOI: 10.1021/Ja00032A058 |
0.354 |
|
| 1992 |
Henkel T, Sailer M, Helms GL, Stiles ME, Vederas JC. NMR assignment of leucocin A, a bacteriocin from Leuconostoc gelidum, supported by a stable isotope-labeling technique for peptides and proteins Journal of the American Chemical Society. 114: 1898-1900. DOI: 10.1021/Ja00031A064 |
0.321 |
|
| 1991 |
Hastings JW, Sailer M, Johnson K, Roy KL, Vederas JC, Stiles ME. Characterization of leucocin A-UAL 187 and cloning of the bacteriocin gene from Leuconostoc gelidum. Journal of Bacteriology. 173: 7491-500. PMID 1840587 DOI: 10.1128/Jb.173.23.7491-7500.1991 |
0.338 |
|
| 1991 |
Zabriskie TM, Cheng H, Vederas JC. Incorporation of aerobic oxygen into the hydroxyglycyl intermediate during formation of C-terminal peptide amides by peptidylglycine α-amidating monooxygenase (PAM) Journal of the Chemical Society, Chemical Communications. 571-572. DOI: 10.1039/C39910000571 |
0.359 |
|
| 1991 |
Pu Y, Martin FM, Vederas JC. Synthesis and acylation of salts of L-threonine .beta.-lactone: a route to .beta.-lactone antibiotics The Journal of Organic Chemistry. 56: 1280-1283. DOI: 10.1021/Jo00003A062 |
0.301 |
|
| 1990 |
Gelb MH, Lin Y, Pickard MA, Song Y, Vederas JC. Synthesis of 3-fluorodiaminopimelic acid isomers as inhibitors of diaminopimelate epimerase: stereocontrolled enzymatic elimination of hydrogen fluoride Journal of the American Chemical Society. 112: 4932-4942. DOI: 10.1021/Ja00168A045 |
0.304 |
|
| 1990 |
Yoshizawa Y, Li Z, Reese PB, Vederas JC. Intact incorporation of acetate-derived di- and tetraketides during biosynthesis of dehydrocurvularin, a macrolide phytotoxin from Alternaria cinerariae Journal of the American Chemical Society. 112: 3212-3213. DOI: 10.1021/Ja00164A053 |
0.33 |
|
| 1989 |
Li Z, Rawlings BJ, Harrison PH, Vederas JC. Production of new polyene antibiotics by Streptomyces cellulosae after addition of ethyl (Z)-16-phenylhexadec-9-enoate. The Journal of Antibiotics. 42: 577-84. PMID 2722673 DOI: 10.7164/Antibiotics.42.577 |
0.336 |
|
| 1989 |
Ramer SE, Cheng H, Vederas JC. Investigations of polypeptide biosynthesis: formation of peptide amides Pure and Applied Chemistry. 61: 489-492. DOI: 10.1351/Pac198961030489 |
0.374 |
|
| 1989 |
Johnson LB, Reese PB, Roberts EV, Lam LKP, Vederas JC. Structure elucidation of cordifolin A, a novel cucurbitacin from Fevillea cordifolia, using one and two dimensional n.m.r. techniques Journal of the Chemical Society-Perkin Transactions 1. 2111-2116. DOI: 10.1039/P19890002111 |
0.302 |
|
| 1989 |
Pansare SV, Vederas JC. Synthesis and reactivity of .beta.-lactones derived from L-threonine and related amino acids The Journal of Organic Chemistry. 54: 2311-2316. DOI: 10.1021/Jo00271A013 |
0.304 |
|
| 1989 |
Arai K, Rawlings BJ, Yoshizawa Y, Vederas JC. Biosyntheses of antibiotic A26771B by Penicillium turbatum and dehydrocurvularin by Alternaria cinerariae: comparison of stereochemistry of polyketide and fatty acid enoyl thiol ester reductases Journal of the American Chemical Society. 111: 3391-3399. DOI: 10.1021/Ja00191A042 |
0.303 |
|
| 1988 |
Ramer SE, Cheng H, Palcic MM, Vederas JC. Formation of peptide amides by peptidylglycine .alpha.-amidating monooxygenase: a new assay and stereochemistry of hydrogen loss Journal of the American Chemical Society. 110: 8526-8532. DOI: 10.1021/Ja00233A032 |
0.314 |
|
| 1988 |
Noguchi H, Harrison PH, Arai K, Nakashima TT, Trimble LA, Vederas JC. Biosynthesis and full NMR assignment of fungichromin, a polyene antibiotic from Streptomyces cellulose Journal of the American Chemical Society. 110: 2938-2945. DOI: 10.1021/Ja00217A041 |
0.31 |
|
| 1986 |
He XG, Chang CC, Chang CJ, Vederas JC, McInnes AG, Walter JA, Floss HG. Further studies on the biosynthesis of granaticin. Zeitschrift FüR Naturforschung. C, Journal of Biosciences. 41: 215-21. PMID 2939642 DOI: 10.1515/znc-1986-1-232 |
0.453 |
|
| 1986 |
Ramer SE, Moore RN, Vederas JC. Mechanism of formation of serine β-lactones by Mitsunobu cyclization: synthesis and use of L-serine stereospecifically labelled with deuterium at C-3 Canadian Journal of Chemistry. 64: 706-713. DOI: 10.1139/V86-113 |
0.333 |
|
| 1986 |
Hogg AM, Kelland JG, Vederas JC, Tamm C. Nucleosides and nucleotides part 24 Investigation of ribo- and deoxyribonucleosides and -nucleotides by fast- atom-bombardment mass spectrometry Helvetica Chimica Acta. 69: 908-917. DOI: 10.1002/Chin.198639058 |
0.443 |
|
| 1985 |
Kelland JG, Palcic MM, Pickard MA, Vederas JC. Stereochemistry of lysine formation by meso-diaminopimelate decarboxylase from wheat germ: use of 1H-13C NMR shift correlation to detect stereospecific deuterium labeling. Biochemistry. 24: 3263-7. PMID 3927976 DOI: 10.1021/Bi00334A028 |
0.319 |
|
| 1983 |
Holker JSE, O'Brien E, Moore RN, Vederas JC. The distribution of acetate-derived oxygens in the tetronic acids of Penicillium multicolor Journal of the Chemical Society, Chemical Communications. 192-194. DOI: 10.1039/C39830000192 |
0.313 |
|
| 1982 |
Vederas JC. Biosynthetic studies using 18O isotope shifts in 13C nuclear magnetic resonance Canadian Journal of Chemistry. 60: 1637-1642. DOI: 10.1139/V82-223 |
0.309 |
|
| 1982 |
Vederas J, Floss H. Additions and Corrections - Stereochemistry of Pyridoxal Phosphate Catalyzed Enzyme Reactions Accounts of Chemical Research. 15: 94-94. DOI: 10.1021/Ar00075A601 |
0.492 |
|
| 1982 |
Floss HG, Vederas JC. Chapter 4 Stereochemistry of pyridoxal phosphate-catalyzed reactions New Comprehensive Biochemistry. 3: 161-199. DOI: 10.1016/S0167-7306(08)60395-6 |
0.516 |
|
| 1980 |
Wyss R, Tamm C, Vederas JC. Differential Hydrogen Exchange During Biosynthesis of Cytochalasins B and D Helvetica Chimica Acta. 63: 1538-1541. DOI: 10.1002/Hlca.19800630622 |
0.497 |
|
| 1980 |
Vederas JC, Floss HG. Stereochemistry of pyridoxal phosphate catalyzed enzyme reactions Accounts of Chemical Research. 13: 455-463. DOI: 10.1002/Chin.198116352 |
0.489 |
|
| 1978 |
Vederas JC, Schleicher E, Tsai MD, Floss HG. Stereochemistry and mechanism of reactions catalyzed by tryptophanase Escherichia coli. The Journal of Biological Chemistry. 253: 5350-4. PMID 353050 |
0.57 |
|
| 1977 |
Tatum C, Vederas J, Schleicher E, Benkovic SJ, Floss H. Stereospecificity of thymidylate synthetase Journal of the Chemical Society, Chemical Communications. 218-220. DOI: 10.1039/C39770000218 |
0.476 |
|
| 1976 |
Vederas JC, Tamm C. Biosynthesis of cytochalasans. Part 6. The mode of incorporation of phenylalanine into cytochalasin D1. Helvetica Chimica Acta. 59: 558-66. PMID 1254501 DOI: 10.1002/Hlca.19760590221 |
0.444 |
|
| 1975 |
Vederas JC, Graf W, David L, Tamm C. Biosynthesis of cytochalasans. Part 4. The mode of incorporation of common naturally-occurring carboxylic acids into cytochalasin D1. Helvetica Chimica Acta. 58: 1886-98. PMID 1194050 DOI: 10.1002/Hlca.19750580704 |
0.515 |
|
| 1974 |
Graf W, Robert JL, Vederas JC, Tamm C, Solomon PH, Miura I, Nakanishi N. Biosynthesis of the cytochalasans. Part III. C-NMR. of cytochalasin B (phomin) and cytochalasin D. Incorporation of [1-13C]- and [2-13C]-sodium acetate. Helvetica Chimica Acta. 57: 1801-15. PMID 4465343 DOI: 10.1002/Hlca.19740570630 |
0.515 |
|
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