David J. Hackam, M.D., Ph.D. - Publications

Johns Hopkins University, Baltimore, MD 

138 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Keswani SG, Moles CM, Morowitz M, Zeh H, Kuo JS, Levine MH, Cheng LS, Hackam DJ, Ahuja N, Goldstein AM. The Future of Basic Science in Academic Surgery: Identifying Barriers to Success for Surgeon-scientists. Annals of Surgery. PMID 27643928 DOI: 10.1097/SLA.0000000000002009  0.68
2016 Good M, Sodhi CP, Yamaguchi Y, Jia H, Lu P, Fulton WB, Martin LY, Prindle T, Nino DF, Zhou Q, Ma C, Ozolek JA, Buck RH, Goehring KC, Hackam DJ. The human milk oligosaccharide 2'-fucosyllactose attenuates the severity of experimental necrotising enterocolitis by enhancing mesenteric perfusion in the neonatal intestine. The British Journal of Nutrition. 1-13. PMID 27609061 DOI: 10.1017/S0007114516002944  0.68
2016 Niño DF, Sodhi CP, Egan CE, Zhou Q, Lin J, Lu P, Yamaguchi Y, Jia H, Martin LY, Good M, Fulton WB, Prindle T, Ozolek JA, Hackam DJ. Retinoic Acid Improves Incidence and Severity of Necrotizing Enterocolitis by Lymphocyte Balance Restitution and Repopulation of LGR5+ Intestinal Stem Cells. Shock (Augusta, Ga.). PMID 27488085 DOI: 10.1097/SHK.0000000000000713  0.68
2016 Sacco Casamassima MG, Gause CD, Goldstein SD, Abdullah F, Meoded A, Lukish JR, Wolfgang CL, Cameron J, Hackam DJ, Hruban RH, Colombani PM. Pancreatic surgery for tumors in children and adolescents. Pediatric Surgery International. PMID 27364750 DOI: 10.1007/s00383-016-3925-y  0.68
2016 Jia H, Sodhi CP, Yamaguchi Y, Lu P, Martin LY, Good M, Zhou Q, Sung J, Fulton WB, Nino DF, Prindle T, Ozolek JA, Hackam DJ. Pulmonary Epithelial TLR4 Activation Leads to Lung Injury in Neonatal Necrotizing Enterocolitis. Journal of Immunology (Baltimore, Md. : 1950). PMID 27307558 DOI: 10.4049/jimmunol.1600618  0.68
2015 Egan CE, Sodhi CP, Good M, Lin J, Jia H, Yamaguchi Y, Lu P, Ma C, Branca MF, Weyandt S, Fulton WB, Niño DF, Prindle T, Ozolek JA, Hackam DJ. Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis. The Journal of Clinical Investigation. PMID 26690704 DOI: 10.1172/JCI83356  0.68
2015 Fritz M, Klawonn AM, Nilsson A, Singh AK, Zajdel J, Björk Wilhelms D, Lazarus M, Löfberg A, Jaarola M, Örtegren Kugelberg U, Billiar TR, Hackam DJ, Sodhi CP, Breyer MD, Jakobsson J, et al. Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice. The Journal of Clinical Investigation. PMID 26690700 DOI: 10.1172/JCI83844  0.68
2015 Deng M, Ma T, Yan Z, Zettel KR, Scott MJ, Liao H, Frank A, Morelli AE, Sodhi CP, Hackam DJ, Billiar TR. TLR4 signaling on dendritic cells suppresses polymorphonuclear leukocytes CXCR2 expression and trafficking via IL-10 during intra-abdominal sepsis. The Journal of Infectious Diseases. PMID 26603204 DOI: 10.1093/infdis/jiv562  0.68
2015 Cai J, Yuan H, Wang Q, Yang H, Al-Abed Y, Hua Z, Wang J, Chen D, Wu J, Lu B, Pribis JP, Jiang W, Yang K, Hackam DJ, Tracey KJ, et al. HMGB1-Driven Inflammation and Intimal Hyperplasia After Arterial Injury Involves Cell-Specific Actions Mediated by TLR4. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 26515416 DOI: 10.1161/ATVBAHA.115.305789  0.4
2015 Shaffiey SA, Jia H, Keane T, Costello C, Wasserman D, Quidgley M, Dziki J, Badylak S, Sodhi CP, March JC, Hackam DJ. Intestinal stem cell growth and differentiation on a tubular scaffold with evaluation in small and large animals. Regenerative Medicine. PMID 26395928 DOI: 10.2217/rme.15.70  0.68
2015 Hackam DJ. The dawn of the third renaissance in surgery. Surgery. 158: 317-22. PMID 26088923 DOI: 10.1016/j.surg.2015.05.001  0.68
2015 Good M, Sodhi CP, Egan CE, Afrazi A, Jia H, Yamaguchi Y, Lu P, Branca MF, Ma C, Prindle T, Mielo S, Pompa A, Hodzic Z, Ozolek JA, Hackam DJ. Breast milk protects against the development of necrotizing enterocolitis through inhibition of Toll-like receptor 4 in the intestinal epithelium via activation of the epidermal growth factor receptor. Mucosal Immunology. PMID 25899687 DOI: 10.1038/mi.2015.30  0.68
2015 Sodhi CP, Jia H, Yamaguchi Y, Lu P, Good M, Egan C, Ozolek J, Zhu X, Billiar TR, Hackam DJ. Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut. Journal of Immunology (Baltimore, Md. : 1950). 194: 4931-9. PMID 25862813 DOI: 10.4049/jimmunol.1402490  0.68
2015 Buchholz BM, Shapiro RA, Vodovotz Y, Billiar TR, Sodhi CP, Hackam DJ, Bauer AJ. Myocyte TLR4 enhances enteric and systemic inflammation driving late murine endotoxic ileus. American Journal of Physiology. Gastrointestinal and Liver Physiology. 308: G852-62. PMID 25747352 DOI: 10.1152/ajpgi.00211.2014  0.68
2015 Wipf P, Eyer BR, Yamaguchi Y, Zhang F, Neal MD, Sodhi CP, Good M, Branca M, Prindle T, Lu P, Brodsky JL, Hackam DJ. Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4) Tetrahedron Letters. 56: 3097-3100. DOI: 10.1016/j.tetlet.2014.11.048  0.68
2014 Hackam DJ. Letter to the editor: Rebuttal. Journal of Pediatric Surgery. 49: 1872. PMID 25487505 DOI: 10.1016/j.jpedsurg.2014.09.057  0.68
2014 Brower-Sinning R, Zhong D, Good M, Firek B, Baker R, Sodhi CP, Hackam DJ, Morowitz MJ. Mucosa-associated bacterial diversity in necrotizing enterocolitis. Plos One. 9: e105046. PMID 25203729 DOI: 10.1371/journal.pone.0105046  0.68
2014 Ding N, Chen G, Hoffman R, Loughran PA, Sodhi CP, Hackam DJ, Billiar TR, Neal MD. Toll-like receptor 4 regulates platelet function and contributes to coagulation abnormality and organ injury in hemorrhagic shock and resuscitation. Circulation. Cardiovascular Genetics. 7: 615-24. PMID 25049041 DOI: 10.1161/CIRCGENETICS.113.000398  0.68
2014 Sho S, Neal MD, Sperry J, Hackam DJ. A novel scoring system to predict the development of necrotizing enterocolitis totalis in premature infants. Journal of Pediatric Surgery. 49: 1053-6. PMID 24952787 DOI: 10.1016/j.jpedsurg.2013.10.023  0.68
2014 Good M, Sodhi CP, Hackam DJ. Evidence-based feeding strategies before and after the development of necrotizing enterocolitis. Expert Review of Clinical Immunology. 10: 875-84. PMID 24898361 DOI: 10.1586/1744666X.2014.913481  0.68
2014 Lu P, Sodhi CP, Jia H, Shaffiey S, Good M, Branca MF, Hackam DJ. Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges. American Journal of Physiology. Gastrointestinal and Liver Physiology. 306: G917-28. PMID 24763555 DOI: 10.1152/ajpgi.00422.2013  0.68
2014 Good M, Sodhi CP, Ozolek JA, Buck RH, Goehring KC, Thomas DL, Vikram A, Bibby K, Morowitz MJ, Firek B, Lu P, Hackam DJ. Lactobacillus rhamnosus HN001 decreases the severity of necrotizing enterocolitis in neonatal mice and preterm piglets: evidence in mice for a role of TLR9. American Journal of Physiology. Gastrointestinal and Liver Physiology. 306: G1021-32. PMID 24742987 DOI: 10.1152/ajpgi.00452.2013  0.68
2014 Bauer EM, Chanthaphavong RS, Sodhi CP, Hackam DJ, Billiar TR, Bauer PM. Genetic deletion of toll-like receptor 4 on platelets attenuates experimental pulmonary hypertension. Circulation Research. 114: 1596-600. PMID 24637196 DOI: 10.1161/CIRCRESAHA.114.303662  0.68
2014 Afrazi A, Branca MF, Sodhi CP, Good M, Yamaguchi Y, Egan CE, Lu P, Jia H, Shaffiey S, Lin J, Ma C, Vincent G, Prindle T, Weyandt S, Neal MD, ... ... Hackam DJ, et al. Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis. The Journal of Biological Chemistry. 289: 9584-99. PMID 24519940 DOI: 10.1074/jbc.M113.526517  0.68
2014 Costello CM, Hongpeng J, Shaffiey S, Yu J, Jain NK, Hackam D, March JC. Synthetic small intestinal scaffolds for improved studies of intestinal differentiation. Biotechnology and Bioengineering. 111: 1222-32. PMID 24390638 DOI: 10.1002/bit.25180  0.68
2014 Lu P, Sodhi CP, Hackam DJ. Toll-like receptor regulation of intestinal development and inflammation in the pathogenesis of necrotizing enterocolitis. Pathophysiology : the Official Journal of the International Society For Pathophysiology / Isp. 21: 81-93. PMID 24365655 DOI: 10.1016/j.pathophys.2013.11.007  0.68
2013 Neal MD, Jia H, Eyer B, Good M, Guerriero CJ, Sodhi CP, Afrazi A, Prindle T, Ma C, Branca M, Ozolek J, Brodsky JL, Wipf P, Hackam DJ. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. Plos One. 8: e65779. PMID 23776545 DOI: 10.1371/journal.pone.0065779  0.68
2013 Hackam DJ, Afrazi A, Good M, Sodhi CP. Innate immune signaling in the pathogenesis of necrotizing enterocolitis. Clinical & Developmental Immunology. 2013: 475415. PMID 23762089 DOI: 10.1155/2013/475415  0.68
2013 Yazji I, Sodhi CP, Lee EK, Good M, Egan CE, Afrazi A, Neal MD, Jia H, Lin J, Ma C, Branca MF, Prindle T, Richardson WM, Ozolek J, Billiar TR, ... ... Hackam DJ, et al. Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling. Proceedings of the National Academy of Sciences of the United States of America. 110: 9451-6. PMID 23650378 DOI: 10.1073/pnas.1219997110  0.68
2013 Hackam DJ, Good M, Sodhi CP. Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch. Seminars in Pediatric Surgery. 22: 76-82. PMID 23611610 DOI: 10.1053/j.sempedsurg.2013.01.003  0.68
2013 Ford HR, Hackam DJ. Management of premature infants. Preface. Seminars in Pediatric Surgery. 22: 67-8. PMID 23611608 DOI: 10.1053/j.sempedsurg.2013.01.001  0.68
2013 Deng M, Scott MJ, Loughran P, Gibson G, Sodhi C, Watkins S, Hackam D, Billiar TR. Lipopolysaccharide clearance, bacterial clearance, and systemic inflammatory responses are regulated by cell type-specific functions of tlr4 during sepsis Journal of Immunology. 190: 5152-5160. PMID 23562812 DOI: 10.4049/jimmunol.1300496  0.68
2013 Nace GW, Huang H, Klune JR, Eid RE, Rosborough BR, Korff S, Li S, Shapiro RA, Stolz DB, Sodhi CP, Hackam DJ, Geller DA, Billiar TR, Tsung A. Cellular-specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury in mice. Hepatology (Baltimore, Md.). 58: 374-87. PMID 23460269 DOI: 10.1002/hep.26346  0.68
2013 Neal MD, Sodhi CP, Dyer M, Craig BT, Good M, Jia H, Yazji I, Afrazi A, Richardson WM, Beer-Stolz D, Ma C, Prindle T, Grant Z, Branca MF, Ozolek J, ... Hackam DJ, et al. A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis. Journal of Immunology (Baltimore, Md. : 1950). 190: 3541-51. PMID 23455503 DOI: 10.4049/jimmunol.1202264  0.68
2013 Arciero JC, Mi Q, Branca M, Hackam D, Swigon D. Using a continuum model to predict closure time of gaps in intestinal epithelial cell layers. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 21: 256-65. PMID 23421747 DOI: 10.1111/j.1524-475X.2012.00865.x  0.68
2013 Arciero J, Bard Ermentrout G, Siggers R, Afrazi A, Hackam D, Vodovotz Y, Rubin J. Modeling the interactions of bacteria and Toll-like receptor-mediated inflammation in necrotizing enterocolitis Journal of Theoretical Biology. 321: 83-99. PMID 23238281 DOI: 10.1016/j.jtbi.2012.12.002  0.68
2013 Naiditch JA, Barsness KA, Fitz C, Hackam DJ. Massive congenital lymphatic malformation of the small intestine: Case report and review of the literature Journal of Pediatric Surgery Case Reports. 1: 325-327. DOI: 10.1016/j.epsc.2013.08.014  0.68
2012 Neal MD, Sodhi CP, Jia H, Dyer M, Egan CE, Yazji I, Good M, Afrazi A, Marino R, Slagle D, Ma C, Branca MF, Prindle T, Grant Z, Ozolek J, ... Hackam DJ, et al. Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis. The Journal of Biological Chemistry. 287: 37296-308. PMID 22955282 DOI: 10.1074/jbc.M112.375881  0.68
2012 Sodhi CP, Neal MD, Siggers R, Sho S, Ma C, Branca MF, Prindle T, Russo AM, Afrazi A, Good M, Brower-Sinning R, Firek B, Morowitz MJ, Ozolek JA, Gittes GK, ... ... Hackam DJ, et al. Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice. Gastroenterology. 143: 708-18.e1-5. PMID 22796522 DOI: 10.1053/j.gastro.2012.05.053  0.68
2012 Good M, Siggers RH, Sodhi CP, Afrazi A, Alkhudari F, Egan CE, Neal MD, Yazji I, Jia H, Lin J, Branca MF, Ma C, Prindle T, Grant Z, Shah S, ... ... Hackam DJ, et al. Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium. Proceedings of the National Academy of Sciences of the United States of America. 109: 11330-5. PMID 22733781 DOI: 10.1073/pnas.1200856109  0.68
2012 Li HH, Li Q, Liu P, Liu Y, Li J, Wasserloos K, Chao W, You M, Oury TD, Chhinder S, Hackam DJ, Billiar TR, Leikauf GD, Pitt BR, Zhang LM. WNT1-inducible signaling pathway protein 1 contributes to ventilator-induced lung injury. American Journal of Respiratory Cell and Molecular Biology. 47: 528-35. PMID 22700866 DOI: 10.1165/rcmb.2012-0127OC  0.68
2012 Yi H, Patel AK, Sodhi CP, Hackam DJ, Hackam AS. Novel role for the innate immune receptor Toll-like receptor 4 (TLR4) in the regulation of the Wnt signaling pathway and photoreceptor apoptosis. Plos One. 7: e36560. PMID 22615780 DOI: 10.1371/journal.pone.0036560  0.68
2012 Afrazi A, Sodhi CP, Good M, Jia H, Siggers R, Yazji I, Ma C, Neal MD, Prindle T, Grant ZS, Branca MF, Ozolek J, Chang EB, Hackam DJ. Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium. Journal of Immunology (Baltimore, Md. : 1950). 188: 4543-57. PMID 22461698 DOI: 10.4049/jimmunol.1103114  0.68
2012 Hackam DJ. Guts, germs and glucose: understanding the effects of prematurity on the interaction between bacteria and nutrient absorption across the intestine. The British Journal of Nutrition. 108: 571-3. PMID 22136881 DOI: 10.1017/S0007114511006416  0.68
2012 Tomaszewski JJ, Smaldone MC, Cannon GM, Schneck FX, Hackam DJ, Docimo SG. Cloacal exstrophy variant with intravesical phallus: further description of anatomy and implications for gender reassignment. Journal of Pediatric Urology. 8: 426-30. PMID 22061965 DOI: 10.1016/j.jpurol.2011.09.003  0.68
2011 Siggers RH, Hackam DJ. The role of innate immune-stimulated epithelial apoptosis during gastrointestinal inflammatory diseases. Cellular and Molecular Life Sciences : Cmls. 68: 3623-34. PMID 21986983 DOI: 10.1007/s00018-011-0821-4  0.68
2011 Hackam DJ. Danger at the doorstep: regulation of bacterial translocation across the intestinal barrier by nitric oxide. Critical Care Medicine. 39: 2189-90. PMID 21849832 DOI: 10.1097/CCM.0b013e31822661ad  0.68
2011 Lin J, Hackam DJ. Worms, flies and four-legged friends: the applicability of biological models to the understanding of intestinal inflammatory diseases. Disease Models & Mechanisms. 4: 447-56. PMID 21669933 DOI: 10.1242/dmm.007252  0.68
2011 Arciero JC, Mi Q, Branca MF, Hackam DJ, Swigon D. Continuum model of collective cell migration in wound healing and colony expansion. Biophysical Journal. 100: 535-43. PMID 21281567 DOI: 10.1016/j.bpj.2010.11.083  0.68
2011 Sodhi C, Levy R, Gill R, Neal MD, Richardson W, Branca M, Russo A, Prindle T, Billiar TR, Hackam DJ. DNA attenuates enterocyte Toll-like receptor 4-mediated intestinal mucosal injury after remote trauma. American Journal of Physiology. Gastrointestinal and Liver Physiology. 300: G862-73. PMID 21233273 DOI: 10.1152/ajpgi.00373.2010  0.68
2011 Afrazi A, Sodhi CP, Richardson W, Neal M, Good M, Siggers R, Hackam DJ. New insights into the pathogenesis and treatment of necrotizing enterocolitis: Toll-like receptors and beyond. Pediatric Research. 69: 183-8. PMID 21135755 DOI: 10.1203/PDR.0b013e3182093280  0.68
2011 Shah SR, Esni F, Jakub A, Paredes J, Lath N, Malek M, Potoka DA, Prasadan K, Mastroberardino PG, Shiota C, Guo P, Miller KA, Hackam DJ, Burns RC, Tulachan SS, et al. Embryonic mouse blood flow and oxygen correlate with early pancreatic differentiation. Developmental Biology. 349: 342-9. PMID 21050843 DOI: 10.1016/j.ydbio.2010.10.033  0.68
2011 Neal MD, Richardson WM, Sodhi CP, Russo A, Hackam DJ. Intestinal stem cells and their roles during mucosal injury and repair. The Journal of Surgical Research. 167: 1-8. PMID 20599211 DOI: 10.1016/j.jss.2010.04.037  0.68
2011 Gill R, Ruan X, Menzel CL, Namkoong S, Loughran P, Hackam DJ, Billiar TR. Systemic inflammation and liver injury following hemorrhagic shock and peripheral tissue trauma involve functional TLR9 signaling on bone marrow-derived cells and parenchymal cells. Shock (Augusta, Ga.). 35: 164-70. PMID 20577143 DOI: 10.1097/SHK.0b013e3181eddcab  0.68
2011 Neal MD, Hackam DJ. Tension pneumopericardium in an infant. Surgery. 149: 457-8. PMID 19962168 DOI: 10.1016/j.surg.2009.10.013  0.68
2010 Kim AC, Langer JC, Pastor AC, Zhang L, Sloots CE, Hamilton NA, Neal MD, Craig BT, Tkach EK, Hackam DJ, Bax NM, Dillon PA, Chamberlain JN, Teitelbaum DH. Endorectal pull-through for Hirschsprung's disease-a multicenter, long-term comparison of results: transanal vs transabdominal approach. Journal of Pediatric Surgery. 45: 1213-20. PMID 20620323 DOI: 10.1016/j.jpedsurg.2010.02.087  0.68
2010 Richardson WM, Sodhi CP, Russo A, Siggers RH, Afrazi A, Gribar SC, Neal MD, Dai S, Prindle T, Branca M, Ma C, Ozolek J, Hackam DJ. Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4 signaling in the intestinal epithelium. Gastroenterology. 139: 904-17, 917.e1-6. PMID 20580721 DOI: 10.1053/j.gastro.2010.05.038  0.68
2010 Costello BJ, Hueser T, Mandell D, Hackam D, Prosen TL. Syndromic micrognathia and peri-natal management with the ex-utero intra-partum treatment (EXIT) procedure International Journal of Oral and Maxillofacial Surgery. 39: 725-728. PMID 20303239 DOI: 10.1016/j.ijom.2010.02.017  0.68
2010 Dai S, Sodhi C, Cetin S, Richardson W, Branca M, Neal MD, Prindle T, Ma C, Shapiro RA, Li B, Wang JH, Hackam DJ. Extracellular high mobility group box-1 (HMGB1) inhibits enterocyte migration via activation of Toll-like receptor-4 and increased cell-matrix adhesiveness. The Journal of Biological Chemistry. 285: 4995-5002. PMID 20007974 DOI: 10.1074/jbc.M109.067454  0.68
2010 Sodhi CP, Shi XH, Richardson WM, Grant ZS, Shapiro RA, Prindle T, Branca M, Russo A, Gribar SC, Ma C, Hackam DJ. Toll-like receptor-4 inhibits enterocyte proliferation via impaired beta-catenin signaling in necrotizing enterocolitis. Gastroenterology. 138: 185-96. PMID 19786028 DOI: 10.1053/j.gastro.2009.09.045  0.68
2009 Neal MD, Sippey M, Gaines BA, Hackam DJ. Presence of pneumomediastinum after blunt trauma in children: what does it really mean? Journal of Pediatric Surgery. 44: 1322-7. PMID 19573655 DOI: 10.1016/j.jpedsurg.2009.02.069  0.68
2009 Gribar SC, Sodhi CP, Richardson WM, Anand RJ, Gittes GK, Branca MF, Jakub A, Shi XH, Shah S, Ozolek JA, Hackam DJ. Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis. Journal of Immunology (Baltimore, Md. : 1950). 182: 636-46. PMID 19109197  0.68
2008 Anand RJ, Dai S, Gribar SC, Richardson W, Kohler JW, Hoffman RA, Branca MF, Li J, Shi XH, Sodhi CP, Hackam DJ. A role for connexin43 in macrophage phagocytosis and host survival after bacterial peritoneal infection. Journal of Immunology (Baltimore, Md. : 1950). 181: 8534-43. PMID 19050272  0.68
2008 Sodhi C, Richardson W, Gribar S, Hackam DJ. The development of animal models for the study of necrotizing enterocolitis. Disease Models & Mechanisms. 1: 94-8. PMID 19048070 DOI: 10.1242/dmm.000315  0.68
2008 Defranco BH, Nickel BM, Baty CJ, Martinez JS, Gay VL, Sandulache VC, Hackam DJ, Murray SA. Migrating cells retain gap junction plaque structure and function. Cell Communication & Adhesion. 15: 273-88. PMID 18979295 DOI: 10.1080/15419060802198298  0.68
2008 Leaphart CL, Dai S, Gribar SC, Richardson W, Ozolek J, Shi XH, Bruns JR, Branca M, Li J, Weisz OA, Sodhi C, Hackam DJ. Interferon-gamma inhibits enterocyte migration by reversibly displacing connexin43 from lipid rafts. American Journal of Physiology. Gastrointestinal and Liver Physiology. 295: G559-69. PMID 18635599 DOI: 10.1152/ajpgi.90320.2008  0.68
2008 Gribar SC, Richardson WM, Sodhi CP, Hackam DJ. No longer an innocent bystander: epithelial toll-like receptor signaling in the development of mucosal inflammation. Molecular Medicine (Cambridge, Mass.). 14: 645-59. PMID 18584047 DOI: 10.2119/2008-00035.Gribar  0.68
2008 Aziz A, Healey JM, Qureshi F, Kane TD, Kurland G, Green M, Hackam DJ. Comparative analysis of chest tube thoracostomy and video-assisted thoracoscopic surgery in empyema and parapneumonic effusion associated with pneumonia in children. Surgical Infections. 9: 317-23. PMID 18570573 DOI: 10.1089/sur.2007.025  0.68
2008 Mollen KP, Gribar SC, Anand RJ, Kaczorowski DJ, Kohler JW, Branca MF, Dubowski TD, Sodhi CP, Hackam DJ. Increased expression and internalization of the endotoxin coreceptor CD14 in enterocytes occur as an early event in the development of experimental necrotizing enterocolitis. Journal of Pediatric Surgery. 43: 1175-81. PMID 18558203 DOI: 10.1016/j.jpedsurg.2008.02.050  0.68
2008 Leaphart CL, Borland K, Kane TD, Hackam DJ. Hypertrophic pyloric stenosis in newborns younger than 21 days: remodeling the path of surgical intervention. Journal of Pediatric Surgery. 43: 998-1001. PMID 18558172 DOI: 10.1016/j.jpedsurg.2008.02.022  0.68
2008 Gribar SC, Anand RJ, Sodhi CP, Hackam DJ. The role of epithelial Toll-like receptor signaling in the pathogenesis of intestinal inflammation. Journal of Leukocyte Biology. 83: 493-8. PMID 18160540 DOI: 10.1189/jlb.0607358  0.68
2008 Anand RJ, Dai S, Rippel C, Leaphart C, Qureshi F, Gribar SC, Kohler JW, Li J, Stolz DB, Sodhi C, Hackam DJ. Activated macrophages inhibit enterocyte gap junctions via the release of nitric oxide. American Journal of Physiology. Gastrointestinal and Liver Physiology. 294: G109-19. PMID 17975131 DOI: 10.1152/ajpgi.00331.2007  0.68
2008 Nadler EP, Hackam DJ. Laparoscopic Resection of a Pheochromocytoma at the Organ of Zuckerkandl in a 13-year old child Surgical Endoscopy. 1. DOI: 10.1007/s00464-006-9146-z  0.96
2007 Leaphart CL, Cavallo J, Gribar SC, Cetin S, Li J, Branca MF, Dubowski TD, Sodhi CP, Hackam DJ. A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair. Journal of Immunology (Baltimore, Md. : 1950). 179: 4808-20. PMID 17878380  0.68
2007 Mi Q, Swigon D, Rivière B, Cetin S, Vodovotz Y, Hackam DJ. One-dimensional elastic continuum model of enterocyte layer migration. Biophysical Journal. 93: 3745-52. PMID 17704181 DOI: 10.1529/biophysj.107.112326  0.36
2007 Anand RJ, Gribar SC, Li J, Kohler JW, Branca MF, Dubowski T, Sodhi CP, Hackam DJ. Hypoxia causes an increase in phagocytosis by macrophages in a HIF-1alpha-dependent manner. Journal of Leukocyte Biology. 82: 1257-65. PMID 17675562 DOI: 10.1189/jlb.0307195  0.68
2007 Levy RM, Mollen KP, Prince JM, Kaczorowski DJ, Vallabhaneni R, Liu S, Tracey KJ, Lotze MT, Hackam DJ, Fink MP, Vodovotz Y, Billiar TR. Systemic inflammation and remote organ injury following trauma require HMGB1. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 293: R1538-44. PMID 17652366 DOI: 10.1152/ajpregu.00272.2007  0.68
2007 Leaphart CL, Qureshi F, Cetin S, Li J, Dubowski T, Baty C, Batey C, Beer-Stolz D, Guo F, Murray SA, Hackam DJ. Interferon-gamma inhibits intestinal restitution by preventing gap junction communication between enterocytes. Gastroenterology. 132: 2395-411. PMID 17570214 DOI: 10.1053/j.gastro.2007.03.029  0.68
2007 Anand RJ, Kohler JW, Cavallo JA, Li J, Dubowski T, Hackam DJ. Toll-like receptor 4 plays a role in macrophage phagocytosis during peritoneal sepsis. Journal of Pediatric Surgery. 42: 927-32; discussion 9. PMID 17560196 DOI: 10.1016/j.jpedsurg.2007.01.023  0.68
2007 Fan J, Li Y, Levy RM, Fan JJ, Hackam DJ, Vodovotz Y, Yang H, Tracey KJ, Billiar TR, Wilson MA. Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling. Journal of Immunology (Baltimore, Md. : 1950). 178: 6573-80. PMID 17475888  0.68
2007 Cetin S, Leaphart CL, Li J, Ischenko I, Hayman M, Upperman J, Zamora R, Watkins S, Ford HR, Wang J, Hackam DJ. Nitric oxide inhibits enterocyte migration through activation of RhoA-GTPase in a SHP-2-dependent manner. American Journal of Physiology. Gastrointestinal and Liver Physiology. 292: G1347-58. PMID 17272518 DOI: 10.1152/ajpgi.00375.2006  0.68
2007 Anand RJ, Leaphart CL, Mollen KP, Hackam DJ. The role of the intestinal barrier in the pathogenesis of necrotizing enterocolitis. Shock (Augusta, Ga.). 27: 124-33. PMID 17224785 DOI: 10.1097/01.shk.0000239774.02904.65  0.68
2006 Otteson TD, Hackam DJ, Mandell DL. The Ex Utero Intrapartum Treatment (EXIT) procedure: new challenges. Archives of Otolaryngology--Head & Neck Surgery. 132: 686-9. PMID 16785417 DOI: 10.1001/archotol.132.6.686  0.68
2006 Moss RL, Dimmitt RA, Barnhart DC, Sylvester KG, Brown RL, Powell DM, Islam S, Langer JC, Sato TT, Brandt ML, Lee H, Blakely ML, Lazar EL, Hirschl RB, Kenney BD, ... Hackam DJ, et al. Laparotomy versus peritoneal drainage for necrotizing enterocolitis and perforation. The New England Journal of Medicine. 354: 2225-34. PMID 16723614 DOI: 10.1056/NEJMoa054605  0.68
2006 Nadler EP, Reblock KK, Qureshi FG, Hackam DJ, Gaines BA, Kane TD. Laparoscopic appendectomy in children with perforated appendicitis. Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A. 16: 159-63. PMID 16646709 DOI: 10.1089/lap.2006.16.159  0.68
2006 Leaphart CL, Danko M, Cassidy L, Gaines B, Hackam DJ. An analysis of proctoscopy vs computed tomography scanning in the diagnosis of rectal injuries in children: which is better? Journal of Pediatric Surgery. 41: 700-3; discussion 70. PMID 16567179 DOI: 10.1016/j.jpedsurg.2005.12.012  0.68
2006 Neal MD, Leaphart C, Levy R, Prince J, Billiar TR, Watkins S, Li J, Cetin S, Ford H, Schreiber A, Hackam DJ. Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier. Journal of Immunology (Baltimore, Md. : 1950). 176: 3070-9. PMID 16493066  0.68
2006 Grishin AV, Wang J, Potoka DA, Hackam DJ, Upperman JS, Boyle P, Zamora R, Ford HR. Lipopolysaccharide induces cyclooxygenase-2 in intestinal epithelium via a noncanonical p38 MAPK pathway. Journal of Immunology (Baltimore, Md. : 1950). 176: 580-8. PMID 16365453  0.68
2005 Qureshi FG, Ergun O, Sandulache VC, Nadler EP, Ford HR, Hackam DJ, Kane TD. Laparoscopic splenectomy in children. Jsls : Journal of the Society of Laparoendoscopic Surgeons / Society of Laparoendoscopic Surgeons. 9: 389-92. PMID 16381351  0.68
2005 Anand RJ, Hackam DJ. The role of gap junctions in health and disease. Critical Care Medicine. 33: S535-8. PMID 16340443 DOI: 10.1097/01.CCM.0000194035.40266.B2  0.68
2005 Cetin S, Hackam DJ. An approach to the writing of a scientific manuscript. The Journal of Surgical Research. 128: 165-7. PMID 16154592 DOI: 10.1016/j.jss.2005.07.002  0.68
2005 Upperman JS, Potoka D, Grishin A, Hackam D, Zamora R, Ford HR. Mechanisms of nitric oxide-mediated intestinal barrier failure in necrotizing enterocolitis. Seminars in Pediatric Surgery. 14: 159-66. PMID 16084403 DOI: 10.1053/j.sempedsurg.2005.05.004  0.68
2005 Zamora R, Grishin A, Wong C, Boyle P, Wang J, Hackam D, Upperman JS, Tracey KJ, Ford HR. High-mobility group box 1 protein is an inflammatory mediator in necrotizing enterocolitis: protective effect of the macrophage deactivator semapimod. American Journal of Physiology. Gastrointestinal and Liver Physiology. 289: G643-52. PMID 15947118 DOI: 10.1152/ajpgi.00067.2005  0.68
2005 Qureshi FG, Sandulache VC, Richardson W, Ergun O, Ford HR, Hackam DJ. Primary vs delayed surgery for spontaneous pneumothorax in children: which is better? Journal of Pediatric Surgery. 40: 166-9. PMID 15868579 DOI: 10.1016/j.jpedsurg.2004.09.042  0.68
2005 Qureshi FG, Leaphart C, Cetin S, Li J, Grishin A, Watkins S, Ford HR, Hackam DJ. Increased expression and function of integrins in enterocytes by endotoxin impairs epithelial restitution. Gastroenterology. 128: 1012-22. PMID 15825082 DOI: 10.1053/j.gastro.2005.01.052  0.68
2005 Aziz A, Kane TD, Meza MP, Vaughan KG, Hackam DJ. An unusual cause of rectal bleeding and intestinal obstruction in a child with peripheral vascular malformations. Pediatric Surgery International. 21: 491-3. PMID 15806421 DOI: 10.1007/s00383-005-1399-4  0.68
2005 Vaughan KG, Aziz A, Meza MP, Hackam DJ. Mesenteric inflammatory pseudotumor as a cause of abdominal pain in a teenager: presentation and literature review. Pediatric Surgery International. 21: 497-9. PMID 15789237 DOI: 10.1007/s00383-005-1395-8  0.68
2005 Hackam DJ, Upperman JS, Grishin A, Ford HR. Disordered enterocyte signaling and intestinal barrier dysfunction in the pathogenesis of necrotizing enterocolitis. Seminars in Pediatric Surgery. 14: 49-57. PMID 15770588 DOI: 10.1053/j.sempedsurg.2004.10.025  0.68
2005 Ergün O, Barksdale E, Ergün FS, Prosen T, Qureshi FG, Reblock KR, Ford H, Hackam DJ. The timing of delivery of infants with gastroschisis influences outcome. Journal of Pediatric Surgery. 40: 424-8. PMID 15750942 DOI: 10.1016/j.jpedsurg.2004.10.013  0.68
2005 Ergün O, Qureshi FG, Baty C, Li J, Ford HR, Hackam DJ. Lipopolysaccharide impairs cell-to-cell communication by affecting the gap junction protein connexin-43 in enterocytes | Lipopolisakkarid enterositlerdeki ara baǧlanti proteini konneksin-43′ü etkileyerek hücreler arasi iletişimi bozmaktadir Cocuk Cerrahisi Dergisi. 19: 53-58.  0.68
2005 Ergün O, Barksdale E, Nucci A, Şenuzun F, Yowarski JA, Qureshi F, Hackam DJ. The affect of the ileocecal valve on intestinal adaptation in children with intestinal failure | İleoçekal valvin korunmasinin baǧirsak yetmezlikli hastalarda baǧirsak uyumuna etkisi Cocuk Cerrahisi Dergisi. 19: 106-110.  0.68
2004 Kelly N, Friend K, Boyle P, Zhang XR, Wong C, Hackam DJ, Zamora R, Ford HR, Upperman JS. The role of the glutathione antioxidant system in gut barrier failure in a rodent model of experimental necrotizing enterocolitis. Surgery. 136: 557-66. PMID 15349102 DOI: 10.1016/j.surg.2004.05.034  0.68
2004 Cetin S, Dunklebarger J, Li J, Boyle P, Ergun O, Qureshi F, Ford H, Upperman J, Watkins S, Hackam DJ. Endotoxin differentially modulates the basolateral and apical sodium/proton exchangers (NHE) in enterocytes. Surgery. 136: 375-83. PMID 15300204 DOI: 10.1016/j.surg.2004.05.013  0.68
2004 Grishin A, Wang J, Hackam D, Qureshi F, Upperman J, Zamora R, Ford HR. p38 MAP kinase mediates endotoxin-induced expression of cyclooxygenase-2 in enterocytes. Surgery. 136: 329-35. PMID 15300199 DOI: 10.1016/j.surg.2004.05.008  0.68
2004 Hackam DJ, Mazzioti MV, Pearl RH, Mazziotti GM, Winthrop AL, Langer JC. Mechanisms of pediatric trauma deaths in Canada and the United States: the role of firearms. The Journal of Trauma. 56: 1286-90. PMID 15211138  0.68
2004 Rozmiarek AJ, Qureshi FG, Cassidy L, Ford HR, Gaines BA, Rycus P, Hackam DJ. How low can you go? Effectiveness and safety of extracorporeal membrane oxygenation in low-birth-weight neonates. Journal of Pediatric Surgery. 39: 845-7. PMID 15185209 DOI: 10.1016/j.jpedsurg.2004.02.012  0.68
2004 Rozmiarek AJ, Qureshi FG, Cassidy L, Ford HR, Hackam DJ. Factors influencing survival in newborns with congenital diaphragmatic hernia: the relative role of timing of surgery. Journal of Pediatric Surgery. 39: 821-4; discussion 82. PMID 15185204 DOI: 10.1016/j.jpedsurg.2004.02.010  0.68
2004 Hackam DJ, Reblock KK, Redlinger RE, Barksdale EM. Diagnosis and outcome of Hirschsprung's disease: does age really matter? Pediatric Surgery International. 20: 319-22. PMID 15185108 DOI: 10.1007/s00383-004-1188-5  0.68
2004 Cetin S, Ford HR, Sysko LR, Agarwal C, Wang J, Neal MD, Baty C, Apodaca G, Hackam DJ. Endotoxin inhibits intestinal epithelial restitution through activation of Rho-GTPase and increased focal adhesions. The Journal of Biological Chemistry. 279: 24592-600. PMID 15169791 DOI: 10.1074/jbc.M313620200  0.68
2004 Zuckerbraun BS, Morrison K, Gaines B, Ford HR, Hackam DJ. Effect of age on cervical spine injuries in children after motor vehicle collisions: effectiveness of restraint devices. Journal of Pediatric Surgery. 39: 483-6. PMID 15017574 DOI: 10.1016/j.jpedsurg.2003.11.046  0.68
2003 Hackam DJ, Reblock K, Barksdale EM, Redlinger R, Lynch J, Gaines BA. The influence of Down's syndrome on the management and outcome of children with Hirschsprung's disease. Journal of Pediatric Surgery. 38: 946-9. PMID 12778399 DOI: 10.1016/S0022-3468(03)00129-5  0.68
2002 Hackam DJ, Ford HR. Cellular, biochemical, and clinical aspects of wound healing. Surgical Infections. 3: S23-35. PMID 12573037 DOI: 10.1089/10962960260496316  0.68
2002 Hackam DJ, Potoka D, Meza M, Pollock A, Gardner M, Abrams P, Upperman J, Schall L, Ford H. Utility of radiographic hepatic injury grade in predicting outcome for children after blunt abdominal trauma. Journal of Pediatric Surgery. 37: 386-9. PMID 11877653 DOI: 10.1053/jpsu.2002.30822  0.68
2001 Hackam DJ, Botelho RJ, Sjolin C, Rotstein OD, Robinson JM, Schreiber AD, Grinstein S. Indirect role for COPI in the completion of FCgamma receptor-mediated phagocytosis. The Journal of Biological Chemistry. 276: 18200-8. PMID 11279223 DOI: 10.1074/jbc.M102009200  0.68
2000 Hackam DJ, Ali J, Jastaniah SS. Effects of other intra-abdominal injuries on the diagnosis, management, and outcome of small bowel trauma. The Journal of Trauma. 49: 606-10. PMID 11038076  0.68
2000 Botelho RJ, Hackam DJ, Schreiber AD, Grinstein S. Role of COPI in phagosome maturation. The Journal of Biological Chemistry. 275: 15717-27. PMID 10748188 DOI: 10.1074/jbc.M910068199  0.68
1999 Swenson O. How the cause and cure of Hirschsprung's disease were discovered. Journal of Pediatric Surgery. 34: 1580-1. PMID 10549781 DOI: 10.1016/S0022-3468(99)90138-0  0.68
1999 Govoni G, Canonne-Hergaux F, Pfeifer CG, Marcus SL, Mills SD, Hackam DJ, Grinstein S, Malo D, Finlay BB, Gros P. Functional expression of Nramp1 in vitro in the murine macrophage line RAW264.7. Infection and Immunity. 67: 2225-32. PMID 10225878  0.68
1999 Gruenheid S, Canonne-Hergaux F, Gauthier S, Hackam DJ, Grinstein S, Gros P. The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes. The Journal of Experimental Medicine. 189: 831-41. PMID 10049947 DOI: 10.1084/jem.189.5.831  0.68
1999 Hackam DJ, Kreller M, Pearl RH. Snow-related recreational injuries in children: assessment of morbidity and management strategies. Journal of Pediatric Surgery. 34: 65-8; discussion 69. PMID 10022145 DOI: 10.1016/S0022-3468(99)90230-0  0.68
1999 Hackam DJ, Rotstein OD, Grinstein S. Phagosomal acidification mechanisms and functional significance Advances in Cellular and Molecular Biology of Membranes and Organelles. 5: 299-319. DOI: 10.1016/S1874-5172(99)80037-6  0.68
1998 Hackam DJ, Christou N, Khaliq Y, Duffy DR, Vaughan D, Marshall JC, Rotstein OD. Bioavailability of oral ciprofloxacin in early postsurgical patients. Archives of Surgery (Chicago, Ill. : 1960). 133: 1221-5. PMID 9820354  0.68
1998 Hackam DJ, Rotstein OD, Sjolin C, Schreiber AD, Trimble WS, Grinstein S. v-SNARE-dependent secretion is required for phagocytosis. Proceedings of the National Academy of Sciences of the United States of America. 95: 11691-6. PMID 9751727 DOI: 10.1073/pnas.95.20.11691  0.68
1998 Hackam DJ, Rotstein OD, Zhang W, Gruenheid S, Gros P, Grinstein S. Host resistance to intracellular infection: mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification. The Journal of Experimental Medicine. 188: 351-64. PMID 9670047 DOI: 10.1084/jem.188.2.351  0.68
1998 Hackam DJ, Filler RM, Pearl RH. Enterocolitis after the surgical treatment of Hirschsprung's disease: risk factors and financial impact. Journal of Pediatric Surgery. 33: 830-3. PMID 9660207 DOI: 10.1016/S0022-3468(98)90652-2  0.68
1998 Hackam DJ, Rotstein OD. Host response to laparoscopic surgery: Mechanisms and clinical correlattes Canadian Journal of Surgery. 41: 103-111. PMID 9575992  0.68
1997 Hackam DJ, Rotstein OD, Zhang WJ, Demaurex N, Woodside M, Tsai O, Grinstein S. Regulation of phagosomal acidification. Differential targeting of Na +/H + exchangers, Na +/K +-ATPases, and vacuolar-type H +-ATPases Journal of Biological Chemistry. 272: 29810-29820. PMID 9368053 DOI: 10.1074/jbc.272.47.29810  0.68
1997 West MA, Hackam DJ, Baker J, Rodriguez JL, Bellingham J, Rotstein OD. Mechanism of decreased in vitro murine macrophage cytokine release after exposure to carbon dioxide: relevance to laparoscopic surgery. Annals of Surgery. 226: 179-90. PMID 9296512 DOI: 10.1097/00000658-199708000-00010  0.68
1997 Hackam DJ, Rotstein OD, Schreiber A, Zhang WJ, Grinstein S. Rho is required for the initiation of calcium signaling and phagocytosis by Fcγ receptors in macrophages Journal of Experimental Medicine. 186: 955-966. PMID 9294149 DOI: 10.1084/jem.186.6.955  0.68
1997 Hackam DJ, Superina RA, Pearl RH. Single-stage repair of Hirschsprung's disease: a comparison of 109 patients over 5 years. Journal of Pediatric Surgery. 32: 1028-31; discussion . PMID 9247227 DOI: 10.1016/S0022-3468(97)90392-4  0.68
1997 Hackam DJ, Zalev A, Burnstein M, Rotstein OD, Koo J. Enteric duplication in the adult, derived from the foregut, midgut and hindgut: Presentation, patterns and literature review Canadian Journal of Surgery. 40: 129-133. PMID 9126127  0.68
1996 Hackam DJ, Grinstdn S, Nathens A, William R, Watson G, Marshall JC, Rotstem OD. Exudative neutrophils show impaired pH regulation compared with circulating neutrophils Archives of Surgery. 131: 1296-1301. PMID 8956771  0.68
1996 Hackam DJ, Grinstein S, Rotstein OD. Intracellular pH regulation in leukocytes: Mechanisms and functional significance Shock. 5: 17-21. PMID 8821098  0.68
1996 Hackam DJ, Saibil F, Wilson S, Litwin D. Laparoscopic management of intussusception caused by colonic lipomata: A case report and review of the literature Surgical Laparoscopy and Endoscopy. 6: 155-159. PMID 8680642 DOI: 10.1097/00019509-199604000-00015  0.68
1996 Hackam DJ, Rotstein OD, Bennett MK, Klip A, Grinstein S, Manolson MF. Characterization and subcellular localization of target membrane soluble NSF attachment protein receptors (t-SNAREs) in macrophages. Syntaxins 2, 3, and 4 are present on phagosomal membranes. Journal of Immunology (Baltimore, Md. : 1950). 156: 4377-83. PMID 8666810  0.68
1996 Brisseau GF, Grinstein S, Hackam DJ, Nordström T, Manolson MF, Khine AA, Rotstein OD. Interleukin-1 increases vacuolar-type H +-ATPase activity in murine peritoneal macrophages Journal of Biological Chemistry. 271: 2005-2011. PMID 8567651 DOI: 10.1074/jbc.271.4.2005  0.68
1995 Hackam DJ, Rotstein OD. Wound infection during stoma closure Canadian Journal of Surgery. 38: 191. PMID 7728677  0.68
1995 Hackam DJ, Rotstein OD. Stoma closure and wound infection: An evaluation of risk factors Canadian Journal of Surgery. 38: 144-148. PMID 7728668  0.68
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