| Year |
Citation |
Score |
| 2022 |
Sampadi B, Vermeulen S, Mišovic B, Boei JJ, Batth TS, Chang JG, Paulsen MT, Magnuson B, Schimmel J, Kool H, Olie CS, Everts B, Vertegaal ACO, Olsen JV, Ljungman M, ... Jeggo PA, et al. Divergent Molecular and Cellular Responses to Low and High-Dose Ionizing Radiation. Cells. 11. PMID 36497055 DOI: 10.3390/cells11233794 |
0.316 |
|
| 2022 |
Feng H, Lane KA, Roumeliotis TI, Jeggo PA, Somaiah N, Choudhary JS, Downs JA. PBAF loss leads to DNA damage-induced inflammatory signaling through defective G2/M checkpoint maintenance. Genes & Development. PMID 35902118 DOI: 10.1101/gad.349249.121 |
0.424 |
|
| 2021 |
Shibata A, Jeggo PA. ATM's Role in the Repair of DNA Double-Strand Breaks. Genes. 12. PMID 34573351 DOI: 10.3390/genes12091370 |
0.503 |
|
| 2021 |
Anbalagan S, Ström C, Downs JA, Jeggo PA, McBay D, Wilkins A, Rothkamm K, Harrington KJ, Yarnold JR, Somaiah N. TP53 modulates radiotherapy fraction size sensitivity in normal and malignant cells. Scientific Reports. 11: 7119. PMID 33782505 DOI: 10.1038/s41598-021-86681-6 |
0.305 |
|
| 2020 |
Shibata A, Jeggo PA. Roles for 53BP1 in the repair of radiation-induced DNA double strand breaks. Dna Repair. 93: 102915. PMID 33087281 DOI: 10.1016/j.dnarep.2020.102915 |
0.475 |
|
| 2020 |
Shibata A, Jeggo PA. Roles for the DNA-PK complex and 53BP1 in protecting ends from resection during DNA double-strand break repair. Journal of Radiation Research. PMID 32779701 DOI: 10.1093/jrr/rraa053 |
0.47 |
|
| 2020 |
Shibata A, Jeggo PA. Canonical DNA non-homologous end-joining; capacity versus fidelity. The British Journal of Radiology. 20190966. PMID 31944860 DOI: 10.1259/Bjr.20190966 |
0.571 |
|
| 2019 |
Averbeck D, Candéias S, Chandna S, Foray N, Friedl A, Haghdoost S, Jeggo PA, Lumniczky K, Paris F, Quintens R, Sabatier L. Establishing mechanisms affecting the individual response to ionising radiation. International Journal of Radiation Biology. 1-109. PMID 31852363 DOI: 10.1080/09553002.2019.1704908 |
0.357 |
|
| 2019 |
Barazzuol L, Hopkins SR, Ju L, Jeggo PA. Distinct response of adult neural stem cells to low versus high dose ionising radiation. Dna Repair. 76: 70-75. PMID 30822688 DOI: 10.1016/J.Dnarep.2019.01.004 |
0.347 |
|
| 2019 |
Maerz LD, Tena TC, Gerhards J, Donow C, Jeggo PA, Philipp M. Analysis of cilia dysfunction phenotypes in zebrafish embryos depleted of Origin recognition complex factors European Journal of Human Genetics. 27: 772-782. PMID 30696958 DOI: 10.1038/S41431-019-0338-0 |
0.305 |
|
| 2019 |
Shibata A, Jeggo P. A historical reflection on our understanding of radiation-induced DNA double strand break repair in somatic mammalian cells; interfacing the past with the present. International Journal of Radiation Biology. 1-36. PMID 30608893 DOI: 10.1080/09553002.2018.1564083 |
0.492 |
|
| 2019 |
Meisenberg C, Pinder SI, Hopkins SR, Wooller SK, Benstead-Hume G, Pearl FMG, Jeggo PA, Downs JA. Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability. Molecular Cell. 73: 212-223.e7. PMID 30554942 DOI: 10.1016/J.Molcel.2018.11.001 |
0.473 |
|
| 2019 |
Tena TC, Maerz LD, Szafranski K, Groth M, Blätte TJ, Donow C, Matysik S, Walther P, Jeggo PA, Burkhalter MD, Philipp M. Resting cells rely on the DNA helicase component MCM2 to build cilia. Nucleic Acids Research. 47: 134-151. PMID 30329080 DOI: 10.1093/Nar/Gky945 |
0.462 |
|
| 2018 |
Shibata A, Jeggo P, Löbrich M. The pendulum of the Ku-Ku clock. Dna Repair. PMID 30177438 DOI: 10.1016/J.Dnarep.2018.08.020 |
0.496 |
|
| 2018 |
Yasuda T, Kagawa W, Ogi T, Kato TA, Suzuki T, Dohmae N, Takizawa K, Nakazawa Y, Genet MD, Saotome M, Hama M, Konishi T, Nakajima NI, Hazawa M, Tomita M, ... ... Jeggo PA, et al. Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites. Plos Genetics. 14: e1007277. PMID 29590107 DOI: 10.1371/Journal.Pgen.1007277 |
0.477 |
|
| 2018 |
Somaiah N, Anbalagan S, Strom C, Downs J, Jeggo P, Wilkins A, Boyle S, Rothkamm K, Yarnold J. OC-0380: Cell cycle checkpoint modulates radiotherapy fraction size sensitivity in normal and malignant cells Radiotherapy and Oncology. 127. DOI: 10.1016/S0167-8140(18)30690-X |
0.306 |
|
| 2017 |
Jeggo PA, Löbrich M. DNA non-homologous end-joining enters the resection arena. Oncotarget. 8: 93317-93318. PMID 29212151 DOI: 10.18632/Oncotarget.22075 |
0.496 |
|
| 2017 |
Jeggo PA, Löbrich M. DNA non-homologous end-joining enters the resection arena. Oncotarget. 8: 93317-93318. PMID 29212151 DOI: 10.18632/oncotarget.22075 |
0.399 |
|
| 2017 |
Jeggo PA, Downs JA, Gasser SM. Chromatin modifiers and remodellers in DNA repair and signalling. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 372. PMID 28847816 DOI: 10.1098/Rstb.2016.0279 |
0.585 |
|
| 2017 |
Löbrich M, Jeggo P. A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis. Trends in Biochemical Sciences. 42: 690-701. PMID 28739276 DOI: 10.1016/J.Tibs.2017.06.011 |
0.531 |
|
| 2017 |
Barazzuol L, Ju L, Jeggo PA. A coordinated DNA damage response promotes adult quiescent neural stem cell activation. Plos Biology. 15: e2001264. PMID 28489848 DOI: 10.1371/Journal.Pbio.2001264 |
0.475 |
|
| 2017 |
Biehs R, Steinlage M, Barton O, Juhász S, Künzel J, Spies J, Shibata A, Jeggo PA, Löbrich M. DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination. Molecular Cell. PMID 28132842 DOI: 10.1016/J.Molcel.2016.12.016 |
0.461 |
|
| 2017 |
Barazzuol L, Ju L, Jeggo PA. SP-0115: Response of adult neural stem cells to radiation-induced DNA damage Radiotherapy and Oncology. 123. DOI: 10.1016/S0167-8140(17)30559-5 |
0.473 |
|
| 2016 |
Barazzuol L, Jeggo PA. In vivo sensitivity of the embryonic and adult neural stem cell compartments to low-dose radiation. Journal of Radiation Research. PMID 27125639 DOI: 10.1093/Jrr/Rrw013 |
0.417 |
|
| 2016 |
Stiff T, Casar Tena T, O'Driscoll M, Jeggo PA, Philipp M. ATR promotes cilia signalling; links to developmental impacts. Human Molecular Genetics. PMID 26908596 DOI: 10.1093/Hmg/Ddw034 |
0.411 |
|
| 2015 |
Kakarougkas A, Downs JA, Jeggo PA. The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks. Molecular & Cellular Oncology. 2: e970072. PMID 27308404 DOI: 10.4161/23723548.2014.970072 |
0.517 |
|
| 2015 |
Jeggo PA, Pearl LH, Carr AM. DNA repair, genome stability and cancer: a historical perspective. Nature Reviews. Cancer. PMID 26667849 DOI: 10.1038/Nrc.2015.4 |
0.473 |
|
| 2015 |
Baldock RA, Day M, Wilkinson OJ, Cloney R, Jeggo PA, Oliver AW, Watts FZ, Pearl LH. ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX. Cell Reports. PMID 26628370 DOI: 10.1016/J.Celrep.2015.10.074 |
0.568 |
|
| 2015 |
Jeggo PA, Löbrich M. How cancer cells hijack DNA double-strand break repair pathways to gain genomic instability. The Biochemical Journal. 471: 1-11. PMID 26392571 DOI: 10.1042/Bj20150582 |
0.516 |
|
| 2015 |
Barazzuol L, Rickett N, Ju L, Jeggo PA. Low levels of endogenous or X-ray-induced DNA double-strand breaks activate apoptosis in adult neural stem cells. Journal of Cell Science. 128: 3597-606. PMID 26303202 DOI: 10.1242/Dev.131607 |
0.415 |
|
| 2015 |
Guo C, Nakazawa Y, Woodbine L, Björkman A, Shimada M, Fawcett H, Jia N, Ohyama K, Li TS, Nagayama Y, Mitsutake N, Pan-Hammarström Q, Gennery AR, Lehmann AR, Jeggo PA, et al. XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency. The Journal of Allergy and Clinical Immunology. PMID 26255102 DOI: 10.1016/J.Jaci.2015.06.007 |
0.568 |
|
| 2015 |
Alagoz M, Katsuki Y, Ogiwara H, Ogi T, Shibata A, Kakarougkas A, Jeggo P. SETDB1, HP1 and SUV39 promote repositioning of 53BP1 to extend resection during homologous recombination in G2 cells. Nucleic Acids Research. 43: 7931-44. PMID 26206670 DOI: 10.1093/Nar/Gkv722 |
0.428 |
|
| 2015 |
Lobachevsky P, Woodbine L, Hsiao KC, Choo S, Fraser C, Gray P, Smith J, Best N, Munforte L, Korneeva E, Martin RF, Jeggo PA, Martin OA. Evaluation of Severe Combined Immunodeficiency and Combined Immunodeficiency Pediatric Patients on the Basis of Cellular Radiosensitivity. The Journal of Molecular Diagnostics : Jmd. PMID 26151233 DOI: 10.1016/J.Jmoldx.2015.05.004 |
0.362 |
|
| 2015 |
Woodbine L, Haines J, Coster M, Barazzuol L, Ainsbury E, Sienkiewicz Z, Jeggo P. The rate of X-ray-induced DNA double-strand break repair in the embryonic mouse brain is unaffected by exposure to 50 Hz magnetic fields International Journal of Radiation Biology. 91: 495-499. PMID 25786477 DOI: 10.3109/09553002.2015.1021963 |
0.456 |
|
| 2014 |
Jeggo PA, Downs JA. Roles of chromatin remodellers in DNA double strand break repair. Experimental Cell Research. 329: 69-77. PMID 25278484 DOI: 10.1016/J.Yexcr.2014.09.023 |
0.54 |
|
| 2014 |
Barton O, Naumann SC, Diemer-Biehs R, Künzel J, Steinlage M, Conrad S, Makharashvili N, Wang J, Feng L, Lopez BS, Paull TT, Chen J, Jeggo PA, Löbrich M. Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1. The Journal of Cell Biology. 206: 877-94. PMID 25267294 DOI: 10.1083/Jcb.201401146 |
0.524 |
|
| 2014 |
Saha S, Woodbine L, Haines J, Coster M, Ricket N, Barazzuol L, Ainsbury E, Sienkiewicz Z, Jeggo P. Increased apoptosis and DNA double-strand breaks in the embryonic mouse brain in response to very low-dose X-rays but not 50 Hz magnetic fields. Journal of the Royal Society, Interface / the Royal Society. 11: 20140783. PMID 25209403 DOI: 10.1098/Rsif.2014.0783 |
0.371 |
|
| 2014 |
Kakarougkas A, Ismail A, Chambers AL, Riballo E, Herbert AD, Künzel J, Löbrich M, Jeggo PA, Downs JA. Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin. Molecular Cell. 55: 723-32. PMID 25066234 DOI: 10.1016/J.Molcel.2014.06.028 |
0.543 |
|
| 2014 |
Woodbine L, Gennery AR, Jeggo PA. Reprint of "The clinical impact of deficiency in DNA non-homologous end-joining". Dna Repair. 17: 9-20. PMID 24780557 DOI: 10.1016/j.dnarep.2014.04.002 |
0.459 |
|
| 2014 |
Shibata A, Jeggo PA. DNA double-strand break repair in a cellular context. Clinical Oncology (Royal College of Radiologists (Great Britain)). 26: 243-9. PMID 24630811 DOI: 10.1016/J.Clon.2014.02.004 |
0.544 |
|
| 2014 |
Woodbine L, Gennery AR, Jeggo PA. The clinical impact of deficiency in DNA non-homologous end-joining. Dna Repair. 16: 84-96. PMID 24629483 DOI: 10.1016/j.dnarep.2014.02.011 |
0.459 |
|
| 2014 |
Kakarougkas A, Jeggo PA. DNA DSB repair pathway choice: an orchestrated handover mechanism. The British Journal of Radiology. 87: 20130685. PMID 24363387 DOI: 10.1259/Bjr.20130685 |
0.573 |
|
| 2014 |
Shibata A, Moiani D, Arvai AS, Perry J, Harding SM, Genois MM, Maity R, van Rossum-Fikkert S, Kertokalio A, Romoli F, Ismail A, Ismalaj E, Petricci E, Neale MJ, Bristow RG, ... ... Jeggo PA, et al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Molecular Cell. 53: 7-18. PMID 24316220 DOI: 10.1016/J.Molcel.2013.11.003 |
0.585 |
|
| 2014 |
Shibata A, Moiani D, Arvai AS, Perry J, Harding SM, Genois MM, Maity R, Rossum-Fikkert Sv, Kertokalio A, Romoli F, Ismail A, Ismalaj E, Petricci E, Neale MJ, Bristow RG, ... ... Jeggo PA, et al. Erratum DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities. [Molecular Cell 53, 9, (2014) 7-18] Molecular Cell. 53. DOI: 10.1016/J.Molcel.2014.01.008 |
0.572 |
|
| 2013 |
Lee PP, Woodbine L, Gilmour KC, Bibi S, Cale CM, Amrolia PJ, Veys PA, Davies EG, Jeggo PA, Jones A. The many faces of Artemis-deficient combined immunodeficiency - Two patients with DCLRE1C mutations and a systematic literature review of genotype-phenotype correlation. Clinical Immunology (Orlando, Fla.). 149: 464-74. PMID 24230999 DOI: 10.1016/J.Clim.2013.08.006 |
0.416 |
|
| 2013 |
Yajima H, Fujisawa H, Nakajima NI, Hirakawa H, Jeggo PA, Okayasu R, Fujimori A. The complexity of DNA double strand breaks is a critical factor enhancing end-resection. Dna Repair. 12: 936-46. PMID 24041488 DOI: 10.1016/J.Dnarep.2013.08.009 |
0.599 |
|
| 2013 |
Kakarougkas A, Ismail A, Katsuki Y, Freire R, Shibata A, Jeggo PA. Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection. Nucleic Acids Research. 41: 10298-311. PMID 24013561 DOI: 10.1093/Nar/Gkt802 |
0.433 |
|
| 2013 |
Kakarougkas A, Ismail A, Klement K, Goodarzi AA, Conrad S, Freire R, Shibata A, Lobrich M, Jeggo PA. Opposing roles for 53BP1 during homologous recombination. Nucleic Acids Research. 41: 9719-31. PMID 23969417 DOI: 10.1093/Nar/Gkt729 |
0.687 |
|
| 2013 |
Nakajima NI, Brunton H, Watanabe R, Shrikhande A, Hirayama R, Matsufuji N, Fujimori A, Murakami T, Okayasu R, Jeggo P, Shibata A. Visualisation of γH2AX foci caused by heavy ion particle traversal; distinction between core track versus non-track damage. Plos One. 8: e70107. PMID 23967070 DOI: 10.1371/Journal.Pone.0070107 |
0.411 |
|
| 2013 |
Martin OA, Ivashkevich A, Choo S, Woodbine L, Jeggo PA, Martin RF, Lobachevsky P. Statistical analysis of kinetics, distribution and co-localisation of DNA repair foci in irradiated cells: cell cycle effect and implications for prediction of radiosensitivity. Dna Repair. 12: 844-55. PMID 23891250 DOI: 10.1016/J.Dnarep.2013.07.002 |
0.469 |
|
| 2013 |
Tilgner K, Neganova I, Singhapol C, Saretzki G, Al-Aama JY, Evans J, Gorbunova V, Gennery A, Przyborski S, Stojkovic M, Armstrong L, Jeggo P, Lako M. Brief report: A human induced pluripotent stem cell model of cernunnos deficiency reveals an important role for XLF in the survival of the primitive hematopoietic progenitors Stem Cells. 31: 2015-2023. PMID 23818183 DOI: 10.1002/Stem.1456 |
0.557 |
|
| 2013 |
Woodbine L, Neal JA, Sasi NK, Shimada M, Deem K, Coleman H, Dobyns WB, Ogi T, Meek K, Davies EG, Jeggo PA. PRKDC mutations in a SCID patient with profound neurological abnormalities. The Journal of Clinical Investigation. 123: 2969-80. PMID 23722905 DOI: 10.1172/Jci67349 |
0.56 |
|
| 2013 |
Tilgner K, Neganova I, Moreno-Gimeno I, Al-Aama JY, Burks D, Yung S, Singhapol C, Saretzki G, Evans J, Gorbunova V, Gennery A, Przyborski S, Stojkovic M, Armstrong L, Jeggo P, et al. A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors Cell Death and Differentiation. 20: 1089-1100. PMID 23722522 DOI: 10.1038/Cdd.2013.44 |
0.559 |
|
| 2013 |
Goodarzi AA, Jeggo PA. The repair and signaling responses to DNA double-strand breaks. Advances in Genetics. 82: 1-45. PMID 23721719 DOI: 10.1016/B978-0-12-407676-1.00001-9 |
0.74 |
|
| 2013 |
Stiff T, Alagoz M, Alcantara D, Outwin E, Brunner HG, Bongers EM, O'Driscoll M, Jeggo PA. Deficiency in origin licensing proteins impairs cilia formation: implications for the aetiology of Meier-Gorlin syndrome. Plos Genetics. 9: e1003360. PMID 23516378 DOI: 10.1371/Journal.Pgen.1003360 |
0.431 |
|
| 2013 |
Cottarel J, Frit P, Bombarde O, Salles B, Négrel A, Bernard S, Jeggo PA, Lieber MR, Modesti M, Calsou P. A noncatalytic function of the ligation complex during nonhomologous end joining. The Journal of Cell Biology. 200: 173-86. PMID 23337116 DOI: 10.1083/Jcb.201203128 |
0.59 |
|
| 2012 |
Ogi T, Walker S, Stiff T, Hobson E, Limsirichaikul S, Carpenter G, Prescott K, Suri M, Byrd PJ, Matsuse M, Mitsutake N, Nakazawa Y, Vasudevan P, Barrow M, Stewart GS, ... ... Jeggo PA, et al. Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome. Plos Genetics. 8: e1002945. PMID 23144622 DOI: 10.1371/Journal.Pgen.1002945 |
0.362 |
|
| 2012 |
Goodarzi AA, Jeggo PA. The heterochromatic barrier to DNA double strand break repair: how to get the entry visa. International Journal of Molecular Sciences. 13: 11844-60. PMID 23109886 DOI: 10.3390/Ijms130911844 |
0.746 |
|
| 2012 |
Lee DH, Goodarzi AA, Adelmant GO, Pan Y, Jeggo PA, Marto JA, Chowdhury D. Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response. The Embo Journal. 31: 2403-15. PMID 22491012 DOI: 10.1038/Emboj.2012.86 |
0.685 |
|
| 2012 |
Murray JM, Stiff T, Jeggo PA. DNA double-strand break repair within heterochromatic regions. Biochemical Society Transactions. 40: 173-8. PMID 22260685 DOI: 10.1042/Bst20110631 |
0.584 |
|
| 2012 |
Goodarzi AA, Jeggo PA. Irradiation induced foci (IRIF) as a biomarker for radiosensitivity. Mutation Research. 736: 39-47. PMID 21651917 DOI: 10.1016/J.Mrfmmm.2011.05.017 |
0.652 |
|
| 2011 |
Kato TA, Okayasu R, Jeggo PA, Fujimori A. ASPM influences DNA double-strand break repair and represents a potential target for radiotherapy. International Journal of Radiation Biology. 87: 1189-95. PMID 21923303 DOI: 10.3109/09553002.2011.624152 |
0.513 |
|
| 2011 |
Brunton H, Goodarzi AA, Noon AT, Shrikhande A, Hansen RS, Jeggo PA, Shibata A. Analysis of human syndromes with disordered chromatin reveals the impact of heterochromatin on the efficacy of ATM-dependent G2/M checkpoint arrest. Molecular and Cellular Biology. 31: 4022-35. PMID 21791604 DOI: 10.1128/Mcb.05289-11 |
0.692 |
|
| 2011 |
Jeggo PA, Geuting V, Löbrich M. The role of homologous recombination in radiation-induced double-strand break repair. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 101: 7-12. PMID 21737170 DOI: 10.1016/J.Radonc.2011.06.019 |
0.581 |
|
| 2011 |
Gatz SA, Ju L, Gruber R, Hoffmann E, Carr AM, Wang ZQ, Liu C, Jeggo PA. Requirement for DNA ligase IV during embryonic neuronal development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10088-100. PMID 21734301 DOI: 10.1523/Jneurosci.1324-11.2011 |
0.589 |
|
| 2011 |
Goodarzi AA, Kurka T, Jeggo PA. KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response. Nature Structural & Molecular Biology. 18: 831-9. PMID 21642969 DOI: 10.1038/Nsmb.2077 |
0.708 |
|
| 2011 |
Woodbine L, Brunton H, Goodarzi AA, Shibata A, Jeggo PA. Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair. Nucleic Acids Research. 39: 6986-97. PMID 21596788 DOI: 10.1093/Nar/Gkr331 |
0.758 |
|
| 2011 |
Deckbar D, Jeggo PA, Löbrich M. Understanding the limitations of radiation-induced cell cycle checkpoints. Critical Reviews in Biochemistry and Molecular Biology. 46: 271-83. PMID 21524151 DOI: 10.3109/10409238.2011.575764 |
0.487 |
|
| 2011 |
Bicknell LS, Walker S, Klingseisen A, Stiff T, Leitch A, Kerzendorfer C, Martin CA, Yeyati P, Al Sanna N, Bober M, Johnson D, Wise C, Jackson AP, O'Driscoll M, Jeggo PA. Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. Nature Genetics. 43: 350-5. PMID 21358633 DOI: 10.1038/Ng.776 |
0.395 |
|
| 2011 |
Shibata A, Conrad S, Birraux J, Geuting V, Barton O, Ismail A, Kakarougkas A, Meek K, Taucher-Scholz G, Löbrich M, Jeggo PA. Factors determining DNA double-strand break repair pathway choice in G2 phase. The Embo Journal. 30: 1079-92. PMID 21317870 DOI: 10.1038/Emboj.2011.27 |
0.605 |
|
| 2011 |
Lobrich M, Goodarzi AA, Stiff T, Jeggo PA. Checkpoint control following radiation exposure Current Cancer Research. 19: 53-77. DOI: 10.1007/978-1-4419-8044-1_3 |
0.504 |
|
| 2010 |
Goodarzi AA, Jeggo P, Lobrich M. The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax. Dna Repair. 9: 1273-82. PMID 21036673 DOI: 10.1016/J.Dnarep.2010.09.013 |
0.746 |
|
| 2010 |
Jeggo PA. A break is not the End; insight into the damage response to DNA double strand breaks. Dna Repair. 9: 1217-8. PMID 20956092 DOI: 10.1016/J.Dnarep.2010.09.021 |
0.566 |
|
| 2010 |
Jeggo P. The role of the DNA damage response mechanisms after low-dose radiation exposure and a consideration of potentially sensitive individuals Radiation Research. 174: 825-832. PMID 20738172 DOI: 10.1667/Rr1844.1 |
0.529 |
|
| 2010 |
Woodbine L, Grigoriadou S, Goodarzi AA, Riballo E, Tape C, Oliver AW, van Zelm MC, Buckland MS, Davies EG, Pearl LH, Jeggo PA. An Artemis polymorphic variant reduces Artemis activity and confers cellular radiosensitivity. Dna Repair. 9: 1003-10. PMID 20674517 DOI: 10.1016/J.Dnarep.2010.07.001 |
0.611 |
|
| 2010 |
Löser DA, Shibata A, Shibata AK, Woodbine LJ, Jeggo PA, Chalmers AJ. Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair. Molecular Cancer Therapeutics. 9: 1775-87. PMID 20530711 DOI: 10.1158/1535-7163.Mct-09-1027 |
0.557 |
|
| 2010 |
Deckbar D, Stiff T, Koch B, Reis C, Löbrich M, Jeggo PA. The limitations of the G1-S checkpoint. Cancer Research. 70: 4412-21. PMID 20460507 DOI: 10.1158/0008-5472.Can-09-3198 |
0.39 |
|
| 2010 |
Shibata A, Barton O, Noon AT, Dahm K, Deckbar D, Goodarzi AA, Löbrich M, Jeggo PA. Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G(2)/M checkpoint arrest. Molecular and Cellular Biology. 30: 3371-83. PMID 20421415 DOI: 10.1128/Mcb.01644-09 |
0.722 |
|
| 2010 |
Löbrich M, Shibata A, Beucher A, Fisher A, Ensminger M, Goodarzi AA, Barton O, Jeggo PA. gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization. Cell Cycle (Georgetown, Tex.). 9: 662-9. PMID 20139725 DOI: 10.4161/Cc.9.4.10764 |
0.732 |
|
| 2010 |
Noon AT, Shibata A, Rief N, Löbrich M, Stewart GS, Jeggo PA, Goodarzi AA. 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nature Cell Biology. 12: 177-84. PMID 20081839 DOI: 10.1038/Ncb2017 |
0.735 |
|
| 2010 |
Lee JH, Goodarzi AA, Jeggo PA, Paull TT. 53BP1 promotes ATM activity through direct interactions with the MRN complex. The Embo Journal. 29: 574-85. PMID 20010693 DOI: 10.1038/Emboj.2009.372 |
0.666 |
|
| 2010 |
Slatter M, Barge D, Jeggo P, Nademi Z, Harvey H, Flood T, Cant A, Hambleton S, Abinun M, Gennery A. Haematopoietic Stem Cell Transplantation For DNA-DSB Repair Defects Using A Modified Fanconi Anaemia Conditioning Regimen Biology of Blood and Marrow Transplantation. 16: S249. DOI: 10.1016/J.Bbmt.2009.12.283 |
0.477 |
|
| 2009 |
Goodarzi AA, Jeggo PA. 'A mover and a shaker': 53BP1 allows DNA doublestrand breaks a chance to dance and unite. F1000 Biology Reports. 1: 21. PMID 20948664 DOI: 10.3410/B1-21 |
0.722 |
|
| 2009 |
Jeggo P, Lavin MF. Cellular radiosensitivity: How much better do we understand it? International Journal of Radiation Biology. 85: 1061-1081. PMID 19995233 DOI: 10.3109/09553000903261263 |
0.587 |
|
| 2009 |
Jeggo PA. Risks from low dose/dose rate radiation: what an understanding of DNA damage response mechanisms can tell us. Health Physics. 97: 416-25. PMID 19820451 DOI: 10.1097/Hp.0B013E3181Aff9C8 |
0.587 |
|
| 2009 |
Beucher A, Birraux J, Tchouandong L, Barton O, Shibata A, Conrad S, Goodarzi AA, Krempler A, Jeggo PA, Löbrich M. ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. The Embo Journal. 28: 3413-27. PMID 19779458 DOI: 10.1038/Emboj.2009.276 |
0.717 |
|
| 2009 |
Covo S, de Villartay JP, Jeggo PA, Livneh Z. Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells. Nucleic Acids Research. 37: 6737-45. PMID 19762482 DOI: 10.1093/Nar/Gkp703 |
0.597 |
|
| 2009 |
Nijnik A, Dawson S, Crockford TL, Woodbine L, Visetnoi S, Bennett S, Jones M, Turner GD, Jeggo PA, Goodnow CC, Cornall RJ. Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome. The Journal of Clinical Investigation. 119: 1696-705. PMID 19451691 DOI: 10.1172/Jci32743 |
0.441 |
|
| 2009 |
Goodarzi AA, Noon AT, Jeggo PA. The impact of heterochromatin on DSB repair. Biochemical Society Transactions. 37: 569-76. PMID 19442252 DOI: 10.1042/Bst0370569 |
0.74 |
|
| 2009 |
Riballo E, Woodbine L, Stiff T, Walker SA, Goodarzi AA, Jeggo PA. XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation. Nucleic Acids Research. 37: 482-92. PMID 19056826 DOI: 10.1093/Nar/Gkn957 |
0.692 |
|
| 2008 |
Stiff T, Cerosaletti K, Concannon P, O'Driscoll M, Jeggo PA. Replication independent ATR signalling leads to G2/M arrest requiring Nbs1, 53BP1 and MDC1. Human Molecular Genetics. 17: 3247-53. PMID 18664457 DOI: 10.1093/Hmg/Ddn220 |
0.472 |
|
| 2008 |
Goodarzi AA, Noon AT, Deckbar D, Ziv Y, Shiloh Y, Löbrich M, Jeggo PA. ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Molecular Cell. 31: 167-77. PMID 18657500 DOI: 10.1016/J.Molcel.2008.05.017 |
0.711 |
|
| 2008 |
O'Driscoll M, Jeggo PA. The role of the DNA damage response pathways in brain development and microcephaly: insight from human disorders. Dna Repair. 7: 1039-50. PMID 18458003 DOI: 10.1016/J.Dnarep.2008.03.018 |
0.446 |
|
| 2008 |
O'Driscoll M, Jeggo PA. CsA can induce DNA double-strand breaks: implications for BMT regimens particularly for individuals with defective DNA repair. Bone Marrow Transplantation. 41: 983-9. PMID 18278071 DOI: 10.1038/Bmt.2008.18 |
0.587 |
|
| 2008 |
Griffith E, Walker S, Martin CA, Vagnarelli P, Stiff T, Vernay B, Al Sanna N, Saggar A, Hamel B, Earnshaw WC, Jeggo PA, Jackson AP, O'Driscoll M. Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. Nature Genetics. 40: 232-6. PMID 18157127 DOI: 10.1038/Ng.2007.80 |
0.495 |
|
| 2008 |
Shibata A, Barton O, Noon AT, Dahm K, Deckbar D, Goodarzi AA, Löbrich M, Jeggo PA. The maintenance of ATM dependent G2/M checkpoint arrest following exposure to ionizing radiation Acta Medica Nagasakiensia. 53: 19-21. |
0.538 |
|
| 2008 |
Goodarzi AA, Noon AT, Jeggo PA. Heterochromatic DNA double strand break repair Acta Medica Nagasakiensia. 53: 13-17. |
0.705 |
|
| 2007 |
Jeggo PA, Löbrich M. DNA double-strand breaks: their cellular and clinical impact? Oncogene. 26: 7717-9. PMID 18066083 DOI: 10.1038/Sj.Onc.1210868 |
0.584 |
|
| 2007 |
Löbrich M, Jeggo PA. The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nature Reviews. Cancer. 7: 861-9. PMID 17943134 DOI: 10.1038/Nrc2248 |
0.536 |
|
| 2007 |
Kegel P, Riballo E, Kühne M, Jeggo PA, Löbrich M. X-irradiation of cells on glass slides has a dose doubling impact. Dna Repair. 6: 1692-7. PMID 17644493 DOI: 10.1016/J.Dnarep.2007.05.013 |
0.409 |
|
| 2007 |
Krempler A, Deckbar D, Jeggo PA, Löbrich M. An imperfect G2M checkpoint contributes to chromosome instability following irradiation of S and G2 phase cells. Cell Cycle (Georgetown, Tex.). 6: 1682-6. PMID 17637566 DOI: 10.4161/Cc.6.14.4480 |
0.496 |
|
| 2007 |
O'Driscoll M, Dobyns WB, van Hagen JM, Jeggo PA. Cellular and clinical impact of haploinsufficiency for genes involved in ATR signaling. American Journal of Human Genetics. 81: 77-86. PMID 17564965 DOI: 10.1086/518696 |
0.456 |
|
| 2007 |
Nijnik A, Woodbine L, Marchetti C, Dawson S, Lambe T, Liu C, Rodrigues NP, Crockford TL, Cabuy E, Vindigni A, Enver T, Bell JI, Slijepcevic P, Goodnow CC, Jeggo PA, et al. DNA repair is limiting for haematopoietic stem cells during ageing. Nature. 447: 686-90. PMID 17554302 DOI: 10.1038/Nature05875 |
0.515 |
|
| 2007 |
Deckbar D, Birraux J, Krempler A, Tchouandong L, Beucher A, Walker S, Stiff T, Jeggo P, Löbrich M. Chromosome breakage after G2 checkpoint release Journal of Cell Biology. 176: 749-755. PMID 17353355 DOI: 10.1083/Jcb.200612047 |
0.473 |
|
| 2007 |
Costantini S, Woodbine L, Andreoli L, Jeggo PA, Vindigni A. Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK. Dna Repair. 6: 712-22. PMID 17241822 DOI: 10.1016/J.Dnarep.2006.12.007 |
0.567 |
|
| 2006 |
Jeggo P, Löbrich M. Radiation-induced DNA damage responses Radiation Protection Dosimetry. 122: 124-127. PMID 17351270 DOI: 10.1093/Rpd/Ncl495 |
0.577 |
|
| 2006 |
Stiff T, Walker SA, Cerosaletti K, Goodarzi AA, Petermann E, Concannon P, O'Driscoll M, Jeggo PA. ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. The Embo Journal. 25: 5775-82. PMID 17124492 DOI: 10.1038/Sj.Emboj.7601446 |
0.678 |
|
| 2006 |
O'Driscoll M, Jackson AP, Jeggo PA. Microcephalin: a causal link between impaired damage response signalling and microcephaly. Cell Cycle (Georgetown, Tex.). 5: 2339-44. PMID 17102619 DOI: 10.4161/Cc.5.20.3358 |
0.507 |
|
| 2006 |
Goodarzi AA, Yu Y, Riballo E, Douglas P, Walker SA, Ye R, Härer C, Marchetti C, Morrice N, Jeggo PA, Lees-Miller SP. DNA-PK autophosphorylation facilitates Artemis endonuclease activity. The Embo Journal. 25: 3880-9. PMID 16874298 DOI: 10.1038/Sj.Emboj.7601255 |
0.792 |
|
| 2006 |
Jeggo PA, Löbrich M. Contribution of DNA repair and cell cycle checkpoint arrest to the maintenance of genomic stability. Dna Repair. 5: 1192-8. PMID 16797253 DOI: 10.1016/J.Dnarep.2006.05.011 |
0.573 |
|
| 2006 |
Alderton GK, Galbiati L, Griffith E, Surinya KH, Neitzel H, Jackson AP, Jeggo PA, O'Driscoll M. Regulation of mitotic entry by microcephalin and its overlap with ATR signalling. Nature Cell Biology. 8: 725-33. PMID 16783362 DOI: 10.1038/Ncb1431 |
0.543 |
|
| 2006 |
Marchetti C, Walker SA, Odreman F, Vindigni A, Doherty AJ, Jeggo P. Identification of a novel motif in DNA ligases exemplified by DNA ligase IV Dna Repair. 5: 788-798. PMID 16735143 DOI: 10.1016/J.Dnarep.2006.03.011 |
0.563 |
|
| 2006 |
Evans PM, Woodbine L, Riballo E, Gennery AR, Hubank M, Jeggo PA. Radiation-induced delayed cell death in a hypomorphic Artemis cell line. Human Molecular Genetics. 15: 1303-11. PMID 16540517 DOI: 10.1093/Hmg/Ddl050 |
0.391 |
|
| 2006 |
O'Driscoll M, Jeggo PA. The role of double-strand break repair - insights from human genetics. Nature Reviews. Genetics. 7: 45-54. PMID 16369571 DOI: 10.1038/Nrg1746 |
0.525 |
|
| 2006 |
Löffler H, Bochtler T, Ho AD, Jeggo PA, Bartek J, Krämer A. P39. Chk1 accumulates at the centrosome in response to DNA damage European Journal of Cancer Supplements. 4: 41. DOI: 10.1016/J.Ejcsup.2006.04.099 |
0.517 |
|
| 2005 |
Löbrich M, Jeggo PA. The two edges of the ATM sword: co-operation between repair and checkpoint functions. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 76: 112-8. PMID 16026874 DOI: 10.1016/J.Radonc.2005.06.027 |
0.564 |
|
| 2005 |
Löbrich M, Jeggo PA. Harmonising the response to DSBs: a new string in the ATM bow. Dna Repair. 4: 749-59. PMID 15978533 DOI: 10.1016/J.Dnarep.2004.12.008 |
0.607 |
|
| 2005 |
Cabuy E, Newton C, Joksic G, Woodbine L, Koller B, Jeggo PA, Slijepcevic P. Accelerated telomere shortening and telomere abnormalities in radiosensitive cell lines. Radiation Research. 164: 53-62. PMID 15966765 DOI: 10.1667/Rr3376 |
0.481 |
|
| 2005 |
Jeggo PA, Löbrich M. Artemis links ATM to double strand break rejoining. Cell Cycle (Georgetown, Tex.). 4: 359-62. PMID 15684609 DOI: 10.4161/Cc.4.3.1527 |
0.588 |
|
| 2005 |
Kysela B, Chovanec M, Jeggo PA. Phosphorylation of linker histones by DNA-dependent protein kinase is required for DNA ligase IV-dependent ligation in the presence of histone H1. Proceedings of the National Academy of Sciences of the United States of America. 102: 1877-82. PMID 15671175 DOI: 10.1073/Pnas.0401179102 |
0.512 |
|
| 2005 |
Stiff T, Reis C, Alderton GK, Woodbine L, O'Driscoll M, Jeggo PA. Nbs1 is required for ATR-dependent phosphorylation events. The Embo Journal. 24: 199-208. PMID 15616588 DOI: 10.1038/Sj.Emboj.7600504 |
0.469 |
|
| 2005 |
Collis SJ, DeWeese TL, Jeggo PA, Parker AR. The life and death of DNA-PK. Oncogene. 24: 949-61. PMID 15592499 DOI: 10.1038/Sj.Onc.1208332 |
0.601 |
|
| 2005 |
Loeffler H, Bochtler T, Ho AD, Jeggo PA, Bartek J, Kraemer A. ATM and ATR Are Not Required for DNA Damage-Dependent Accumulation of Chk1 at the Centrosome. Blood. 106: 4288-4288. DOI: 10.1182/Blood.V106.11.4288.4288 |
0.611 |
|
| 2004 |
Riballo E, Kühne M, Rief N, Doherty A, Smith GC, Recio MJ, Reis C, Dahm K, Fricke A, Krempler A, Parker AR, Jackson SP, Gennery A, Jeggo PA, Löbrich M. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Molecular Cell. 16: 715-24. PMID 15574327 DOI: 10.1016/J.Molcel.2004.10.029 |
0.592 |
|
| 2004 |
Alderton GK, Joenje H, Varon R, Børglum AD, Jeggo PA, O'Driscoll M. Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway. Human Molecular Genetics. 13: 3127-38. PMID 15496423 DOI: 10.1093/Hmg/Ddh335 |
0.443 |
|
| 2004 |
Gennery AR, Slatter MA, Bhattacharya A, Barge D, Haigh S, O'Driscoll M, Coleman R, Abinun M, Flood TJ, Cant AJ, Jeggo PA. The clinical and biological overlap between Nijmegen Breakage Syndrome and Fanconi anemia. Clinical Immunology (Orlando, Fla.). 113: 214-9. PMID 15451479 DOI: 10.1016/J.Clim.2004.03.024 |
0.403 |
|
| 2004 |
Girard PM, Kysela B, Härer CJ, Doherty AJ, Jeggo PA. Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms. Human Molecular Genetics. 13: 2369-76. PMID 15333585 DOI: 10.1093/Hmg/Ddh274 |
0.443 |
|
| 2004 |
O'Driscoll M, Gennery AR, Seidel J, Concannon P, Jeggo PA. An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome. Dna Repair. 3: 1227-35. PMID 15279811 DOI: 10.1016/J.Dnarep.2004.03.025 |
0.461 |
|
| 2004 |
Stiff T, Shtivelman E, Jeggo P, Kysela B. AHNAK interacts with the DNA ligase IV-XRCC4 complex and stimulates DNA ligase IV-mediated double-stranded ligation. Dna Repair. 3: 245-56. PMID 15177040 DOI: 10.1016/J.Dnarep.2003.11.001 |
0.552 |
|
| 2004 |
Stiff T, O'Driscoll M, Rief N, Iwabuchi K, Löbrich M, Jeggo PA. ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Research. 64: 2390-6. PMID 15059890 DOI: 10.1158/0008-5472.Can-03-3207 |
0.593 |
|
| 2004 |
Izsvák Z, Stüwe EE, Fiedler D, Katzer A, Jeggo PA, Ivics Z. Healing the wounds inflicted by sleeping beauty transposition by double-strand break repair in mammalian somatic cells. Molecular Cell. 13: 279-90. PMID 14759372 DOI: 10.1016/S1097-2765(03)00524-0 |
0.525 |
|
| 2004 |
Kühne M, Riballo E, Rief N, Rothkamm K, Jeggo PA, Löbrich M. A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity. Cancer Research. 64: 500-8. PMID 14744762 DOI: 10.1158/0008-5472.Can-03-2384 |
0.583 |
|
| 2003 |
Rünger TM, Kotas M, Poot M, Leverkus M, Epe B, Jeggo PA, Hellfritsch D. Reduced joining of DNA ends correlates with chromosomal instability in three melanoma cell lines. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine. 24: 100-8. PMID 12853705 DOI: 10.1159/000071083 |
0.478 |
|
| 2003 |
Iwabuchi K, Basu BP, Kysela B, Kurihara T, Shibata M, Guan D, Cao Y, Hamada T, Imamura K, Jeggo PA, Date T, Doherty AJ. Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA. The Journal of Biological Chemistry. 278: 36487-95. PMID 12824158 DOI: 10.1074/Jbc.M304066200 |
0.572 |
|
| 2003 |
Foray N, Marot D, Gabriel A, Randrianarison V, Carr AM, Perricaudet M, Ashworth A, Jeggo P. A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. The Embo Journal. 22: 2860-71. PMID 12773400 DOI: 10.1093/Emboj/Cdg274 |
0.586 |
|
| 2003 |
Smith J, Riballo E, Kysela B, Baldeyron C, Manolis K, Masson C, Lieber MR, Papadopoulo D, Jeggo P. Impact of DNA ligase IV on the fidelity of end joining in human cells. Nucleic Acids Research. 31: 2157-67. PMID 12682366 DOI: 10.1093/Nar/Gkg317 |
0.57 |
|
| 2003 |
Kysela B, Doherty AJ, Chovanec M, Stiff T, Ameer-Beg SM, Vojnovic B, Girard PM, Jeggo PA. Ku stimulation of DNA ligase IV-dependent ligation requires inward movement along the DNA molecule. The Journal of Biological Chemistry. 278: 22466-74. PMID 12682039 DOI: 10.1074/Jbc.M303273200 |
0.557 |
|
| 2003 |
O'Driscoll M, Ruiz-Perez VL, Woods CG, Jeggo PA, Goodship JA. A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nature Genetics. 33: 497-501. PMID 12640452 DOI: 10.1038/Ng1129 |
0.42 |
|
| 2003 |
Dai Y, Kysela B, Hanakahi LA, Manolis K, Riballo E, Stumm M, Harville TO, West SC, Oettinger MA, Jeggo PA. Nonhomologous end joining and V(D)J recombination require an additional factor. Proceedings of the National Academy of Sciences of the United States of America. 100: 2462-7. PMID 12604777 DOI: 10.1073/Pnas.0437964100 |
0.543 |
|
| 2003 |
Jeggo P, O'Neill P. The Greek Goddess, Artemis, reveals the secrets of her cleavage. Dna Repair. 1: 771-7. PMID 12509281 DOI: 10.1016/S1568-7864(02)00096-4 |
0.462 |
|
| 2002 |
Roddam PL, Rollinson S, O'Driscoll M, Jeggo PA, Jack A, Morgan GJ. Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination. Journal of Medical Genetics. 39: 900-5. PMID 12471202 DOI: 10.1136/Jmg.39.12.900 |
0.386 |
|
| 2002 |
O'Driscoll M, Jeggo P. Immunological disorders and DNA repair Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 509: 109-126. PMID 12427534 DOI: 10.1016/S0027-5107(02)00221-X |
0.445 |
|
| 2002 |
Weller GR, Kysela B, Roy R, Tonkin LM, Scanlan E, Della M, Devine SK, Day JP, Wilkinson A, d'Adda di Fagagna F, Devine KM, Bowater RP, Jeggo PA, Jackson SP, Doherty AJ. Identification of a DNA nonhomologous end-joining complex in bacteria. Science (New York, N.Y.). 297: 1686-9. PMID 12215643 DOI: 10.1126/Science.1074584 |
0.599 |
|
| 2002 |
Jeggo PA. The fidelity of repair of radiation damage. Radiation Protection Dosimetry. 99: 117-22. PMID 12194262 DOI: 10.1093/Oxfordjournals.Rpd.A006740 |
0.561 |
|
| 2002 |
Girard PM, Riballo E, Begg AC, Waugh A, Jeggo PA. Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest. Oncogene. 21: 4191-9. PMID 12082606 DOI: 10.1038/Sj.Onc.1205596 |
0.412 |
|
| 2002 |
Foray N, Marot D, Randrianarison V, Venezia ND, Picard D, Perricaudet M, Favaudon V, Jeggo P. Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation. Molecular and Cellular Biology. 22: 4020-32. PMID 12024016 DOI: 10.1128/Mcb.22.12.4020-4032.2002 |
0.387 |
|
| 2001 |
Jeggo PA, Concannon P. Immune diversity and genomic stability: opposite goals but similar paths. Journal of Photochemistry and Photobiology. B, Biology. 65: 88-96. PMID 11809363 DOI: 10.1016/S1011-1344(01)00243-3 |
0.498 |
|
| 2001 |
O'Driscoll M, Cerosaletti KM, Girard PM, Dai Y, Stumm M, Kysela B, Hirsch B, Gennery A, Palmer SE, Seidel J, Gatti RA, Varon R, Oettinger MA, Neitzel H, Jeggo PA, et al. DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency. Molecular Cell. 8: 1175-85. PMID 11779494 DOI: 10.1016/S1097-2765(01)00408-7 |
0.56 |
|
| 2001 |
Bryntesson F, Regan JC, Jeggo PA, Taccioli GE, Hubank M. Analysis of gene transcription in cells lacking DNA-PK activity. Radiation Research. 156: 167-76. PMID 11448237 DOI: 10.1667/0033-7587(2001)156[0167:Aogtic]2.0.Co;2 |
0.592 |
|
| 2001 |
Rothkamm K, Kühne M, Jeggo PA, Löbrich M. Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks. Cancer Research. 61: 3886-93. PMID 11358801 |
0.488 |
|
| 2001 |
Riballo E, Doherty AJ, Dai Y, Stiff T, Oettinger MA, Jeggo PA, Kysela B. Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity. The Journal of Biological Chemistry. 276: 31124-32. PMID 11349135 DOI: 10.1074/Jbc.M103866200 |
0.506 |
|
| 2001 |
Manolis KG, Nimmo ER, Hartsuiker E, Carr AM, Jeggo PA, Allshire RC. Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe. The Embo Journal. 20: 210-21. PMID 11226171 DOI: 10.1093/Emboj/20.1.210 |
0.598 |
|
| 2001 |
Marangoni E, Foray N, O'Driscoll M, Douc-Rasy S, Bernier J, Bourhis J, Jeggo P. A Ku80 fragment with dominant negative activity imparts a radiosensitive phenotype to CHO-K1 cells. Nucleic Acids Research. 28: 4778-82. PMID 11095690 DOI: 10.1093/Nar/28.23.4778 |
0.597 |
|
| 2000 |
Girard PM, Foray N, Stumm M, Waugh A, Riballo E, Maser RS, Phillips WP, Petrini J, Arlett CF, Jeggo PA. Radiosensitivity in Nijmegen Breakage Syndrome cells is attributable to a repair defect and not cell cycle checkpoint defects. Cancer Research. 60: 4881-8. PMID 10987302 |
0.388 |
|
| 2000 |
Gennery AR, Cant AJ, Jeggo PA. Immunodeficiency associated with DNA repair defects. Clinical and Experimental Immunology. 121: 1-7. PMID 10886231 DOI: 10.1046/J.1365-2249.2000.01257.X |
0.598 |
|
| 2000 |
Beamish HJ, Jessberger R, Riballo E, Priestley A, Blunt T, Kysela B, Jeggo PA. The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity. Nucleic Acids Research. 28: 1506-13. PMID 10710416 |
0.407 |
|
| 1999 |
Woudstra EC, Konings AW, Jeggo PA, Kampinga HH. Role of DNA-PK subunits in radiosensitization by hyperthermia. Radiation Research. 152: 214-8. PMID 10409332 DOI: 10.2307/3580096 |
0.586 |
|
| 1999 |
Jimenez GS, Bryntesson F, Torres-Arzayus MI, Priestley A, Beeche M, Saito S, Sakaguchi K, Appella E, Jeggo PA, Taccioli GE, Wahl GM, Hubank M. DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage. Nature. 400: 81-3. PMID 10403253 DOI: 10.1038/21913 |
0.48 |
|
| 1999 |
Riballo E, Critchlow SE, Teo SH, Doherty AJ, Priestley A, Broughton B, Kysela B, Beamish H, Plowman N, Arlett CF, Lehmann AR, Jackson SP, Jeggo PA. Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient. Current Biology : Cb. 9: 699-702. PMID 10395545 DOI: 10.1016/S0960-9822(99)80311-X |
0.521 |
|
| 1999 |
Singleton BK, Torres-Arzayus MI, Rottinghaus ST, Taccioli GE, Jeggo PA. The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit. Molecular and Cellular Biology. 19: 3267-77. PMID 10207052 DOI: 10.1128/Mcb.19.5.3267 |
0.574 |
|
| 1999 |
Jeggo P, Singleton B, Beamish H, Priestley A. Double strand break rejoining by the Ku-dependent mechanism of non-homologous end-joining. Comptes Rendus De L'AcadéMie Des Sciences. SÉRie Iii, Sciences De La Vie. 322: 109-12. PMID 10196660 DOI: 10.1016/S0764-4469(99)80031-6 |
0.501 |
|
| 1998 |
Jeggo PA. Identification of genes involved in repair of DNA double-strand breaks in mammalian cells. Radiation Research. 150: S80-91. PMID 9806611 |
0.53 |
|
| 1998 |
Taccioli GE, Amatucci AG, Beamish HJ, Gell D, Xiang XH, Torres Arzayus MI, Priestley A, Jackson SP, Marshak Rothstein A, Jeggo PA, Herrera VL. Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity. Immunity. 9: 355-66. PMID 9768755 DOI: 10.1016/S1074-7613(00)80618-4 |
0.439 |
|
| 1998 |
Jeggo PA, Carr AM, Lehmann AR. Splitting the ATM: distinct repair and checkpoint defects in ataxia-telangiectasia. Trends in Genetics : Tig. 14: 312-6. PMID 9724963 DOI: 10.1016/S0168-9525(98)01511-X |
0.404 |
|
| 1998 |
Jeggo PA. DNA breakage and repair. Advances in Genetics. 38: 185-218. PMID 9677708 |
0.503 |
|
| 1998 |
Escarceller M, Buchwald M, Singleton BK, Jeggo PA, Jackson SP, Moustacchi E, Papadopoulo D. Fanconi anemia C gene product plays a role in the fidelity of blunt DNA end-joining. Journal of Molecular Biology. 279: 375-85. PMID 9642044 DOI: 10.1006/jmbi.1998.1784 |
0.409 |
|
| 1998 |
Priestley A, Beamish HJ, Gell D, Amatucci AG, Muhlmann-Diaz MC, Singleton BK, Smith GC, Blunt T, Schalkwyk LC, Bedford JS, Jackson SP, Jeggo PA, Taccioli GE. Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20. Nucleic Acids Research. 26: 1965-73. PMID 9518490 DOI: 10.1093/Nar/26.8.1965 |
0.475 |
|
| 1998 |
Jeggo PA. DNA repair: PARP - another guardian angel? Current Biology : Cb. 8: R49-51. PMID 9427640 DOI: 10.1016/S0960-9822(98)70032-6 |
0.494 |
|
| 1998 |
Jeggo PA. 5 DNA Breakage and Repair Advances in Genetics. 38: 185-218. DOI: 10.1016/S0065-2660(08)60144-3 |
0.503 |
|
| 1997 |
Jeggo PA. DNA-PK: at the cross-roads of biochemistry and genetics. Mutation Research. 384: 1-14. PMID 9201268 DOI: 10.1016/S0921-8777(97)00009-8 |
0.446 |
|
| 1997 |
Singleton BK, Priestley A, Steingrimsdottir H, Gell D, Blunt T, Jackson SP, Lehmann AR, Jeggo PA. Molecular and biochemical characterization of xrs mutants defective in Ku80. Molecular and Cellular Biology. 17: 1264-73. PMID 9032253 DOI: 10.1128/Mcb.17.3.1264 |
0.374 |
|
| 1997 |
Jeggo P, Singleton B, Priestley A, Beamish H, Taccioli G, Gell D, Jackson S. O IX.1 Mutational analysis of the components of DNA-PK Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 379: S61. DOI: 10.1016/S0027-5107(97)82803-5 |
0.409 |
|
| 1996 |
Blunt T, Gell D, Fox M, Taccioli GE, Lehmann AR, Jackson SP, Jeggo PA. Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. Proceedings of the National Academy of Sciences of the United States of America. 93: 10285-90. PMID 8816792 DOI: 10.1073/Pnas.93.19.10285 |
0.59 |
|
| 1996 |
Liang F, Romanienko PJ, Weaver DT, Jeggo PA, Jasin M. Chromosomal double-strand break repair in Ku80-deficient cells. Proceedings of the National Academy of Sciences of the United States of America. 93: 8929-33. PMID 8799130 DOI: 10.1073/pnas.93.17.8929 |
0.484 |
|
| 1996 |
Finnie NJ, Gottlieb TM, Blunt T, Jeggo PA, Jackson SP. DNA-dependent protein kinase defects are linked to deficiencies in DNA repair and V(D)J recombination. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 351: 173-9. PMID 8650264 DOI: 10.1098/Rstb.1996.0014 |
0.596 |
|
| 1995 |
Blunt T, Taccioli GE, Priestley A, Hafezparast M, McMillan T, Liu J, Cole CC, White J, Alt FW, Jackson SP, Schurr E, Lehmann AR, Jeggo PA. A YAC Contig Encompassing the XRCC5 (Ku80) DNA Repair Gene and Complementation of Defective Cells by YAC Protoplast Fusion Genomics. 30: 320-328. PMID 8586433 DOI: 10.1006/Geno.1995.9871 |
0.507 |
|
| 1995 |
Jackson SP, Jeggo PA. DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK Trends in Biochemical Sciences. 20: 412-415. PMID 8533154 DOI: 10.1016/S0968-0004(00)89090-8 |
0.589 |
|
| 1995 |
Jeggo PA, Taccioli GE, Jackson SP. Menage a trois: Double strand break repair, V(D)J recombination and DNA-PK Bioessays. 17: 949-957. PMID 8526889 DOI: 10.1002/Bies.950171108 |
0.545 |
|
| 1995 |
Blunt T, Finnie NJ, Taccioli GE, Smith GCM, Demengeot J, Gottlieb TM, Mizuta R, Varghese AJ, Alt FW, Jeggo PA, Jackson SP. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation Cell. 80: 813-823. PMID 7889575 DOI: 10.1016/0092-8674(95)90360-7 |
0.529 |
|
| 1995 |
Ross GM, Eady JJ, Mithal NP, Bush C, Steel GG, Jeggo PA, McMillan TJ. DNA strand break rejoining defect in xrs-6 is complemented by transfection with the human Ku80 gene Cancer Research. 55: 1235-1238. PMID 7882315 |
0.483 |
|
| 1995 |
Finnie NJ, Gottlieb TM, Blunt T, Jeggo PA, Jackson SP. DNA-dependent protein kinase activity is absent in xrs-6 cells: Implications for site-specific recombination and DNA double-strand break repair Proceedings of the National Academy of Sciences of the United States of America. 92: 320-324. PMID 7816841 DOI: 10.1073/Pnas.92.1.320 |
0.594 |
|
| 1995 |
Zdzienicka MZ, Jongmans W, Oshimura M, Priestley A, Whitmore GF, Jeggo PA. Complementation analysis of the murine scid cell line Radiation Research. 143: 238-244. PMID 7652160 DOI: 10.2307/3579209 |
0.382 |
|
| 1994 |
Taccioli GE, Gottlieb TM, Blunt T, Priestley A, Demengeot J, Mizuta R, Lehmann AR, Alt FW, Jackson SP, Jeggo PA. Ku80: Product of the XRCC5 gene and its role in DNA repair and V(D)J recombination Science. 265: 1442-1445. PMID 8073286 DOI: 10.1126/Science.8073286 |
0.588 |
|
| 1994 |
Jeggo PA, Carr AM, Lehmann AR. Cloning human DNA repair genes International Journal of Radiation Biology. 66: 573-577. PMID 7983449 DOI: 10.1080/09553009414551651 |
0.435 |
|
| 1993 |
Taccioli GE, Rathbun G, Oltz E, Stamato T, Jeggo PA, Alt FW. Impairment of V(D)J recombination in double-strand break repair mutants Science. 260: 207-210. PMID 8469973 DOI: 10.1126/Science.8469973 |
0.477 |
|
| 1993 |
Jeggo PA, Hafezparast M, Thompson AF, Kaur GP, Sandhu AK, Athwal RS. A hamster-human subchromosomal hybrid cell panel for chromosome 2. Somatic Cell and Molecular Genetics. 19: 39-49. PMID 8460397 DOI: 10.1007/Bf01233953 |
0.327 |
|
| 1993 |
Hafezparast M, Kaur GP, Zdzienicka M, Athwal RS, Lehmann AR, Jeggo PA. Subchromosomal localization of a gene (XRCC5) involved in double strand break repair to the region 2q34-36 Somatic Cell and Molecular Genetics. 19: 413-421. PMID 8291019 DOI: 10.1007/Bf01233246 |
0.389 |
|
| 1993 |
Dahm-Daphi J, Dikomey E, Pyttlik C, Jeggo PA. Reparable and non-reparable DNA Strand breaks induced by x-irradiation in CHO k1 cells and the radiosensitive mutants xrs1 and xrs5 International Journal of Radiation Biology. 64: 19-26. PMID 8102167 DOI: 10.1080/09553009314551071 |
0.509 |
|
| 1993 |
Caldecott K, Banks G, Jeggo P. The induction and reversal of topoisomerase II cleavable complexes formed by nuclear extract from the CHO DNA repair mutant, xrs1. Mutation Research. 293: 259-67. PMID 7679476 DOI: 10.1016/0921-8777(93)90077-T |
0.676 |
|
| 1992 |
Jeggo PA, Hafezparast M, Thompson AF, Broughton BC, Kaur GP, Zdzienicka MZ, Athwal RS. Localization of a DNA repair gene (XRCC5) involved in double-strand-break rejoining to human chromosome 2 Proceedings of the National Academy of Sciences of the United States of America. 89: 6423-6427. PMID 1631138 |
0.301 |
|
| 1991 |
Jeggo PA, Tesmer J, Chen DJ. Genetic analysis of ionising radiation sensitive mutants of cultured mammalian cell lines Mutation Research-Dna Repair. 254: 125-133. PMID 2002809 DOI: 10.1016/0921-8777(91)90003-8 |
0.425 |
|
| 1991 |
Caldecott K, Jeggo P. Cross-sensitivity of gamma-ray-sensitive hamster mutants to cross-linking agents. Mutation Research. 255: 111-21. PMID 1922147 DOI: 10.1016/0921-8777(91)90046-R |
0.704 |
|
| 1990 |
Jeggo PA. Studies on mammalian mutants defective in rejoining double-strand breaks in DNA Mutation Research/Reviews in Genetic Toxicology. 239: 1-16. PMID 2195330 DOI: 10.1016/0165-1110(90)90028-A |
0.517 |
|
| 1989 |
Jeggo PA, Smith-Ravin J. Decreased stable transfection frequencies of six X-ray-sensitive CHO strains, all members of the xrs complementation group Mutation Research-Dna Repair. 218: 75-86. PMID 2770766 DOI: 10.1016/0921-8777(89)90013-X |
0.477 |
|
| 1989 |
Smith-Ravin J, Jeggo PA. Use of damaged plasmid to study DNA repair in x-ray sensitive (xrs) strains of chinese hamster ovary (CHO) cells International Journal of Radiation Biology. 56: 951-961. PMID 2574223 DOI: 10.1080/09553008914552411 |
0.381 |
|
| 1989 |
Jeggo PA, Caldecott K, Pidsley S, Banks GR. Sensitivity of Chinese hamster ovary mutants defective in DNA double strand break repair to topoisomerase II inhibitors. Cancer Research. 49: 7057-63. PMID 2479475 |
0.622 |
|
| 1987 |
Bryant PE, Birch DA, Jeggo PA. High chromosomal sensitivity of chinese hamster xrs 5 cells to restriction endonuclease induced DNA double-Strand breaks International Journal of Radiation Biology. 52: 537-554. PMID 2822587 DOI: 10.1080/09553008714552041 |
0.332 |
|
| 1987 |
Gounari F, Banks GR, Khazaie K, Jeggo PA, Holliday R. Gene reactivation: a tool for the isolation of mammalian DNA methylation mutants. Genes & Development. 1: 899-912. PMID 2448188 |
0.549 |
|
| 1986 |
Kemp LM, Jeggo PA. Radiation-induced chromosome damage in X-ray-sensitive mutants (xrs) of the Chinese hamster ovary cell line Mutation Research Dna Repair Reports. 166: 255-263. PMID 3785270 DOI: 10.1016/0167-8817(86)90025-8 |
0.408 |
|
| 1986 |
Jeggo PA, Holliday R. Azacytidine-induced reactivation of a DNA repair gene in Chinese hamster ovary cells. Molecular and Cellular Biology. 6: 2944-9. PMID 2431295 |
0.486 |
|
| 1985 |
Jeggo PA. Genetic analysis of X-ray-sensitive mutants of the CHO cell line Mutation Research Dna Repair Reports. 146: 265-270. PMID 4058443 DOI: 10.1016/0167-8817(85)90067-7 |
0.467 |
|
| 1985 |
Jeggo PA. X-ray sensitive mutants of Chinese hamster ovary cell line: radio-sensitivity of DNA synthesis Mutation Research Dna Repair Reports. 145: 171-176. PMID 4039031 DOI: 10.1016/0167-8817(85)90024-0 |
0.484 |
|
| 1985 |
Holliday R, Jeggo PA. Mechanisms for changing gene expression and their possible relationship to carcinogenesis. Cancer Surveys. 4: 557-81. PMID 3916656 |
0.528 |
|
| 1984 |
Kemp LM, Sedgwick SG, Jeggo PA. X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining Mutation Research Dna Repair Reports. 132: 189-196. PMID 6513971 DOI: 10.1016/0167-8817(84)90037-3 |
0.442 |
|
| 1983 |
Jeggo PA, Kemp LM. X-ray-sensitive mutants of Chinese hamster ovary cell line isolation and cross-sensitivity to other DNA-damaging agents Mutation Research Dna Repair Reports. 112: 313-327. PMID 6197643 DOI: 10.1016/0167-8817(83)90026-3 |
0.406 |
|
| 1982 |
Jeggo PA, Kemp LM, Holliday R. The application of the microbial "tooth-pick" technique to somatic cell genetics, and its use in the isolation of X-ray sensitive mutants of Chinese hamster ovary cells. Biochimie. 64: 713-5. PMID 6814519 DOI: 10.1016/S0300-9084(82)80116-8 |
0.429 |
|
| 1975 |
Jeggo PA, Banks GR. DNA polymerase of Ustilago maydis: Partial characterization of the enzyme and a pol 1 mutation Mgg Molecular & General Genetics. 142: 209-224. PMID 1221304 DOI: 10.1007/Bf00425646 |
0.523 |
|
| 1973 |
Jeggo PA, Unrau P, Banks GR, Holliday R. A temperature sensitive DNA polymerase mutant of Ustilago maydis. Nature: New Biology. 242: 14-6. PMID 4511837 DOI: 10.1038/Newbio242014A0 |
0.663 |
|
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