Christina J. Sigurdson, Ph.D.

Affiliations: 
2001 Colorado State University, Fort Collins, CO 
Area:
Animal Pathology Agriculture, Zoology Biology
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"Christina Sigurdson"

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Edward A. Hoover grad student 2001 Colorado State
 (Chronic wasting disease of mule deer: Transmission and pathogenesis.)
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Publications

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Aguilar-Calvo P, Malik A, Sandoval DR, et al. (2023) Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection. Plos Pathogens. 19: e1011487
Lawrence JA, Aguilar-Calvo P, Ojeda-Juárez D, et al. (2023) Diminished neuronal ESCRT-0 function exacerbates AMPA receptor derangement and accelerates prion-induced neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
Ojeda-Juarez D, Lawrence J, Soldau K, et al. (2022) Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus. Neurobiology of Disease. 105834
Meisl G, Kurt T, Condado-Morales I, et al. (2021) Scaling analysis reveals the mechanism and rates of prion replication in vivo. Nature Structural & Molecular Biology
Asher DM, Belay E, Bigio E, et al. (2020) Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns. Journal of Neuropathology and Experimental Neurology
Mantuano E, Azmoon P, Banki MA, et al. (2020) A soluble derivative of PrP activates cell-signaling and regulates cell physiology through LRP1 and the NMDA Receptor. The Journal of Biological Chemistry
Callender JA, Sevillano AM, Soldau K, et al. (2020) Prion protein post-translational modifications modulate heparan sulfate binding and limit aggregate size in prion disease. Neurobiology of Disease. 104955
Sevillano AM, Aguilar-Calvo P, Kurt TD, et al. (2020) Prion protein glycans reduce intracerebral fibril formation and spongiosis in prion disease. The Journal of Clinical Investigation
Callender JA, Sevillano AM, Soldau K, et al. (2020) Manipulating PrP Glycan Structure to Understand Toxic Signaling Pathways Driving Prion‐Induced Neurodegeneration The Faseb Journal. 34: 1-1
Aguilar-Calvo P, Sevillano AM, Bapat J, et al. (2019) Shortening heparan sulfate chains prolongs survival and reduces parenchymal plaques in prion disease caused by mobile, ADAM10-cleaved prions. Acta Neuropathologica
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