Year |
Citation |
Score |
2006 |
Elban MA, Sun W, Eisenhauer BM, Gao R, Hecht SM. Synthesis and biological evaluation of 10,11-methylenedioxy-14-azacamptothecin. Organic Letters. 8: 3513-6. PMID 16869648 DOI: 10.1021/Ol0611604 |
0.692 |
|
2006 |
Gao R, Zhang Y, Dedkova L, Choudhury AK, Rahier NJ, Hecht SM. Effects of modification of the active site tyrosine of human DNA topoisomerase I. Biochemistry. 45: 8402-10. PMID 16819839 DOI: 10.1021/Bi0605179 |
0.584 |
|
2005 |
Gao R, Zhang Y, Choudhury AK, Dedkova LM, Hecht SM. Analogues of vaccinia virus DNA topoisomerase I modified at the active site tyrosine. Journal of the American Chemical Society. 127: 3321-31. PMID 15755148 DOI: 10.1021/Ja044182Z |
0.523 |
|
2005 |
Rahier NJ, Cheng K, Gao R, Eisenhauer BM, Hecht SM. Synthesis of 14-azacamptothecin, a water-soluble topoisomerase I poison. Organic Letters. 7: 835-7. PMID 15727453 DOI: 10.1021/Ol0400701 |
0.52 |
|
2005 |
Rahier NJ, Eisenhauer BM, Gao R, Thomas SJ, Hecht SM. On the role of E-ring oxygen atoms in the binding of camptothecin to the topoisomerase I-DNA covalent binary complex. Bioorganic & Medicinal Chemistry. 13: 1381-6. PMID 15670945 DOI: 10.1016/J.Bmc.2004.11.011 |
0.573 |
|
2005 |
Cheng K, Rahier NJ, Eisenhauer BM, Gao R, Thomas SJ, Hecht SM. 14-azacamptothecin: a potent water-soluble topoisomerase I poison. Journal of the American Chemical Society. 127: 838-9. PMID 15656613 DOI: 10.1021/Ja0442769 |
0.63 |
|
2004 |
Cagir A, Eisenhauer BM, Gao R, Thomas SJ, Hecht SM. Synthesis and topoisomerase I inhibitory properties of luotonin A analogues. Bioorganic & Medicinal Chemistry. 12: 6287-99. PMID 15519171 DOI: 10.1016/J.Bmc.2004.08.052 |
0.725 |
|
2004 |
Gao R, Claeboe CD, Eisenhauer BM, Hecht SM. Identification of specific nonbridging phosphate oxygens important for DNA cleavage by human topoisomerase I. Biochemistry. 43: 6167-81. PMID 15147201 DOI: 10.1021/Bi040005Z |
0.541 |
|
2004 |
Cagir A, Jones SH, Eisenhauer BM, Gao R, Hecht SM. Synthesis and biochemical properties of E-ring modified luotonin A derivatives. Bioorganic & Medicinal Chemistry Letters. 14: 2051-4. PMID 15080977 DOI: 10.1016/J.Bmcl.2004.02.069 |
0.73 |
|
2004 |
Rahier NJ, Eisenhauer BM, Gao R, Jones SH, Hecht SM. Water-soluble camptothecin derivatives that are intrinsic topoisomerase I poisons. Organic Letters. 6: 321-4. PMID 14748583 DOI: 10.1021/Ol030119N |
0.55 |
|
2003 |
Cagir A, Jones SH, Gao R, Eisenhauer BM, Hecht SM. Luotonin A. A naturally occurring human DNA topoisomerase I poison. Journal of the American Chemical Society. 125: 13628-9. PMID 14599178 DOI: 10.1021/Ja0368857 |
0.723 |
|
2003 |
Claeboe CD, Gao R, Hecht SM. 3'-modified oligonucleotides by reverse DNA synthesis. Nucleic Acids Research. 31: 5685-91. PMID 14500832 DOI: 10.1093/Nar/Gkg734 |
0.59 |
|
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