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Philip D. Compton, Ph.D. - Publications

Affiliations: 
2009 University of Virginia, Charlottesville, VA 
Area:
Analytical Biochemistry
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45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Shi RL, Dillon MA, Compton PD, Sawyer WS, Thorup JR, Kwong M, Chan P, Chiu CPC, Li R, Yadav R, Lee GY, Gober JG, Li Z, ElSohly AM, Ovacik AM, et al. High-Throughput Analyses of Therapeutic Antibodies Using High-Field Asymmetric Waveform Ion Mobility Spectrometry Combined with SampleStream and Intact Protein Mass Spectrometry. Analytical Chemistry. PMID 37956201 DOI: 10.1021/acs.analchem.3c03158  0.375
2022 McGee JP, Senko MW, Jooß K, Des Soye BJ, Compton PD, Kelleher NL, Kafader JO. Automated Control of Injection Times for Unattended Acquisition of Multiplexed Individual Ion Mass Spectra. Analytical Chemistry. PMID 36416365 DOI: 10.1021/acs.analchem.2c03495  0.43
2021 Santos Seckler HD, Park HM, Lloyd-Jones CM, Melani RD, Camarillo JM, Wilkins JT, Compton PD, Kelleher NL. New Interface for Faster Proteoform Analysis: Immunoprecipitation Coupled with SampleStream-Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 34043341 DOI: 10.1021/jasms.1c00026  0.311
2020 Fornelli L, Srzentić K, Toby TK, Doubleday PF, Huguet R, Mullen C, Melani RD, Dos Santos Seckler H, DeHart CJ, Weisbrod CR, Durbin KR, Greer JB, Early BP, Fellers RT, Zabrouskov V, ... ... Compton PD, et al. Thorough Performance Evaluation of 213 nm Ultraviolet Photodissociation for Top-down Proteomics. Molecular & Cellular Proteomics : McP. 19: 405-420. PMID 33451396 DOI: 10.1074/mcp.TIR119.001638  0.376
2020 McGee JP, Melani RD, Yip PF, Senko MW, Compton PD, Kafader JO, Kelleher NL. Isotopic Resolution of Protein Complexes up to 466 kDa Using Individual Ion Mass Spectrometry. Analytical Chemistry. PMID 33322893 DOI: 10.1021/acs.analchem.0c03282  0.456
2020 McGee JP, Melani RD, Goodwin M, McAlister G, Huguet R, Senko MW, Compton PD, Kelleher NL. Voltage Rollercoaster Filtering of Low-Mass Contaminants During Native Protein Analysis. Journal of the American Society For Mass Spectrometry. 31: 763-767. PMID 32126774 DOI: 10.1021/Jasms.9B00037  0.456
2020 Kafader JO, Melani RD, Durbin KR, Ikwuagwu B, Early BP, Fellers RT, Beu SC, Zabrouskov V, Makarov AA, Maze JT, Shinholt DL, Yip PF, Tullman-Ercek D, Senko MW, Compton PD, et al. Multiplexed mass spectrometry of individual ions improves measurement of proteoforms and their complexes. Nature Methods. PMID 32123391 DOI: 10.1038/S41592-020-0764-5  0.525
2020 Kafader JO, Durbin KR, Melani RD, Des Soye BJ, Schachner LF, Senko MW, Compton PD, Kelleher NL. Individual Ion Mass Spectrometry Enhances the Sensitivity and Sequence Coverage of Top-Down Mass Spectrometry. Journal of Proteome Research. PMID 32032494 DOI: 10.1021/Acs.Jproteome.9B00797  0.55
2020 Kafader JO, Melani RD, Schachner LF, Ives A, Patrie SM, Kelleher NL, Compton PD. Native vs Denatured: An in Depth Investigation of Charge State and Isotope Distributions. Journal of the American Society For Mass Spectrometry. PMID 31971796 DOI: 10.1021/Jasms.9B00040  0.486
2019 Fornelli L, Srzentić K, Toby TK, Doubleday PF, Huguet R, Mullen C, Melani RD, Dos Santos Seckler H, DeHart CJ, Weisbrod CR, Durbin KR, Greer JB, Early BP, Fellers RT, Zabrouskov V, ... ... Compton PD, et al. Thorough performance evaluation of 213 nm ultraviolet photodissociation for top-down proteomics. Molecular & Cellular Proteomics : McP. PMID 31888965 DOI: 10.1074/Mcp.Tir119.001638  0.469
2019 Park HM, Winton VJ, Drader JJ, Manalili Wheeler S, Lazar GA, Kelleher NL, Liu Y, Tran JC, Compton PD. A Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry. Analytical Chemistry. PMID 31880920 DOI: 10.1021/Acs.Analchem.9B04826  0.435
2019 Kafader JO, Beu SC, Early BP, Melani RD, Durbin KR, Zabrouskov V, Makarov AA, Maze JT, Shinholt DL, Yip PF, Kelleher NL, Compton PD, Senko MW. STORI Plots Enable Accurate Tracking of Individual Ion Signals. Journal of the American Society For Mass Spectrometry. PMID 31512223 DOI: 10.1007/S13361-019-02309-0  0.443
2019 Schachner LF, Ives AN, McGee JP, Melani RD, Kafader JO, Compton PD, Patrie SM, Kelleher NL. Standard Proteoforms and Their Complexes for Native Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 30963455 DOI: 10.1007/S13361-019-02191-W  0.451
2019 Kafader JO, Melani RD, Senko MW, Makarov AA, Kelleher NL, Compton PD. Measurement of Individual Ions Sharply Increases the Resolution of Orbitrap Mass Spectra of Proteins. Analytical Chemistry. PMID 30609364 DOI: 10.1021/Acs.Analchem.8B04519  0.525
2018 Compton PD, Kelleher NL, Gunawardena J. Estimating the distribution of protein post-translational modification states by mass-spectrometry. Journal of Proteome Research. PMID 29945451 DOI: 10.1021/Acs.Jproteome.8B00150  0.422
2018 Fornelli L, Srzentić K, Huguet R, Mullen C, Sharma S, Zabrouskov V, Fellers RT, Durbin KR, Compton PD, Kelleher NL. Accurate sequence analysis of a monoclonal antibody by top-down and middle-down Orbitrap mass spectrometry applying multiple ion activation techniques. Analytical Chemistry. PMID 29894161 DOI: 10.1021/Acs.Analchem.8B00984  0.52
2017 Skinner OS, Haverland NA, Fornelli L, Melani RD, Do Vale LHF, Seckler HS, Doubleday PF, Schachner LF, Srzentić K, Kelleher NL, Compton PD. Top-down characterization of endogenous protein complexes with native proteomics. Nature Chemical Biology. PMID 29131144 DOI: 10.1038/Nchembio.2515  0.428
2017 Lyon YA, Riggs D, Fornelli L, Compton PD, Julian RR. The Ups and Downs of Repeated Cleavage and Internal Fragment Production in Top-Down Proteomics. Journal of the American Society For Mass Spectrometry. PMID 29038993 DOI: 10.1007/S13361-017-1823-8  0.516
2017 Skinner OS, McAnally MO, Van Duyne RP, Schatz GC, Breuker K, Compton PD, Kelleher NL. Native Electron Capture Dissociation Maps to Iron-Binding Channels in Horse Spleen Ferritin. Analytical Chemistry. PMID 28938074 DOI: 10.1021/Acs.Analchem.7B01581  0.379
2017 Haverland NA, Skinner OS, Fellers RT, Tariq AA, Early BP, LeDuc RD, Fornelli L, Compton PD, Kelleher NL. Defining Gas-Phase Fragmentation Propensities of Intact Proteins During Native Top-Down Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 28374312 DOI: 10.1007/S13361-017-1635-X  0.5
2017 Fornelli L, Durbin KR, Fellers RT, Early BP, Greer JB, LeDuc RD, Compton PD, Kelleher NL. Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer. Journal of Proteome Research. 16: 609-618. PMID 28152595 DOI: 10.1021/Acs.Jproteome.6B00698  0.39
2016 Zhou Y, Zhang X, Fornelli L, Compton PD, Kelleher N, Wirth MJ. Chromatographic efficiency and selectivity in top-down proteomics of histones. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1044: 47-53. PMID 28076774 DOI: 10.1016/J.Jchromb.2016.12.027  0.32
2016 Melani RD, Skinner OS, Fornelli L, Domont GB, Compton PD, Kelleher NL. Mapping proteoforms and protein complexes from king cobra venom using both denaturing and native top-down proteomics. Molecular & Cellular Proteomics : McP. PMID 27178327 DOI: 10.1074/Mcp.M115.056523  0.452
2016 Melani RD, Seckler HS, Skinner OS, Do Vale LH, Catherman AD, Havugimana PC, Valle de Sousa M, Domont GB, Kelleher NL, Compton PD. CN-GELFrEE - Clear Native Gel-eluted Liquid Fraction Entrapment Electrophoresis. Journal of Visualized Experiments : Jove. PMID 26967310 DOI: 10.3791/53597  0.388
2016 Skinner OS, Havugimana PC, Haverland NA, Fornelli L, Early BP, Greer JB, Fellers RT, Durbin KR, Do Vale LH, Melani RD, Seckler HS, Nelp MT, Belov ME, Horning SR, Makarov AA, ... ... Compton PD, et al. An informatic framework for decoding protein complexes by top-down mass spectrometry. Nature Methods. PMID 26780093 DOI: 10.1038/Nmeth.3731  0.464
2015 Kim K, Compton PD, Toby TK, Thomas PM, Wilkins JT, Mutharasan RK, Kelleher NL. Reducing protein oxidation in low-flow electrospray enables deeper investigation of proteoforms by top down proteomics. Eupa Open Proteomics. 8: 40-47. PMID 26753126 DOI: 10.1016/J.Euprot.2015.05.005  0.45
2015 Compton PD, Fornelli L, Kelleher NL, Skinner OS. Probing Asymmetric Charge Partitioning of Protein Oligomers during Tandem Mass Spectrometry. International Journal of Mass Spectrometry. 390: 132-136. PMID 26692813 DOI: 10.1016/J.Ijms.2015.08.021  0.448
2015 Ntai I, LeDuc RD, Fellers RT, Erdmann-Gilmore P, Davies SR, Rumsey J, Early BP, Thomas PM, Li S, Compton PD, Ellis MJ, Ruggles KV, Fenyo D, Boja ES, Rodriguez H, et al. Integrated Bottom-up and Top-down Proteomics of Patient-derived Breast Tumor Xenografts. Molecular & Cellular Proteomics : McP. PMID 26503891 DOI: 10.1074/Mcp.M114.047480  0.395
2015 Savaryn JP, Skinner OS, Fornelli L, Fellers RT, Compton PD, Terhune SS, Abecassis MM, Kelleher NL. Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry. Journal of Proteomics. PMID 25952688 DOI: 10.1016/J.Jprot.2015.04.025  0.469
2015 Kim KH, Compton PD, Tran JC, Kelleher NL. Online matrix removal platform for coupling gel-based separations to whole protein electrospray ionization mass spectrometry. Journal of Proteome Research. 14: 2199-206. PMID 25836738 DOI: 10.1021/Pr501331Q  0.485
2015 Skinner OS, Do Vale LH, Catherman AD, Havugimana PC, de Sousa MV, Compton PD, Kelleher NL. Native GELFrEE: a new separation technique for biomolecular assemblies. Analytical Chemistry. 87: 3032-8. PMID 25664979 DOI: 10.1021/Ac504678D  0.443
2014 Kelleher NL, Thomas PM, Ntai I, Compton PD, LeDuc RD. Deep and quantitative top-down proteomics in clinical and translational research. Expert Review of Proteomics. 11: 649-51. PMID 25347991 DOI: 10.1586/14789450.2014.976559  0.395
2014 Skinner OS, Catherman AD, Early BP, Thomas PM, Compton PD, Kelleher NL. Fragmentation of integral membrane proteins in the gas phase. Analytical Chemistry. 86: 4627-34. PMID 24689519 DOI: 10.1021/Ac500864W  0.307
2014 Li Y, Compton PD, Tran JC, Ntai I, Kelleher NL. Optimizing capillary electrophoresis for top-down proteomics of 30-80 kDa proteins. Proteomics. 14: 1158-64. PMID 24596178 DOI: 10.1002/Pmic.201300381  0.493
2014 Durbin KR, Fellers RT, Ntai I, Kelleher NL, Compton PD. Autopilot: an online data acquisition control system for the enhanced high-throughput characterization of intact proteins. Analytical Chemistry. 86: 1485-92. PMID 24400813 DOI: 10.1021/Ac402904H  0.506
2013 Belov ME, Damoc E, Denisov E, Compton PD, Horning S, Makarov AA, Kelleher NL. From protein complexes to subunit backbone fragments: a multi-stage approach to native mass spectrometry. Analytical Chemistry. 85: 11163-73. PMID 24237199 DOI: 10.1021/Ac4029328  0.544
2013 Earley L, Anderson LC, Bai DL, Mullen C, Syka JE, English AM, Dunyach JJ, Stafford GC, Shabanowitz J, Hunt DF, Compton PD. Front-end electron transfer dissociation: a new ionization source. Analytical Chemistry. 85: 8385-90. PMID 23909443 DOI: 10.1021/Ac401783F  0.585
2013 Catherman AD, Li M, Tran JC, Durbin KR, Compton PD, Early BP, Thomas PM, Kelleher NL. Top down proteomics of human membrane proteins from enriched mitochondrial fractions. Analytical Chemistry. 85: 1880-8. PMID 23305238 DOI: 10.1021/Ac3031527  0.438
2012 Compton PD, Kelleher NL. Spinning up mass spectrometry for whole protein complexes. Nature Methods. 9: 1065-6. PMID 23132117 DOI: 10.1038/Nmeth.2216  0.446
2012 Ahlf DR, Compton PD, Tran JC, Early BP, Thomas PM, Kelleher NL. Evaluation of the compact high-field orbitrap for top-down proteomics of human cells. Journal of Proteome Research. 11: 4308-14. PMID 22746247 DOI: 10.1021/Pr3004216  0.527
2012 Compton PD, Strukl JV, Bai DL, Shabanowitz J, Hunt DF. Optimization of electron transfer dissociation via informed selection of reagents and operating parameters. Analytical Chemistry. 84: 1781-5. PMID 22182179 DOI: 10.1021/Ac202807H  0.573
2011 Tran JC, Zamdborg L, Ahlf DR, Lee JE, Catherman AD, Durbin KR, Tipton JD, Vellaichamy A, Kellie JF, Li M, Wu C, Sweet SM, Early BP, Siuti N, LeDuc RD, ... Compton PD, et al. Mapping intact protein isoforms in discovery mode using top-down proteomics. Nature. 480: 254-8. PMID 22037311 DOI: 10.1038/Nature10575  0.447
2011 Compton PD, Zamdborg L, Thomas PM, Kelleher NL. On the scalability and requirements of whole protein mass spectrometry. Analytical Chemistry. 83: 6868-74. PMID 21744800 DOI: 10.1021/Ac2010795  0.543
2010 Wang Z, Udeshi ND, Slawson C, Compton PD, Sakabe K, Cheung WD, Shabanowitz J, Hunt DF, Hart GW. Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis. Science Signaling. 3: ra2. PMID 20068230 DOI: 10.1126/Scisignal.2000526  0.609
2008 Udeshi ND, Compton PD, Shabanowitz J, Hunt DF, Rose KL. Methods for analyzing peptides and proteins on a chromatographic timescale by electron-transfer dissociation mass spectrometry. Nature Protocols. 3: 1709-17. PMID 18927556 DOI: 10.1038/Nprot.2008.159  0.697
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