☰

jian zhang - Publications

Affiliations: 
Shanghai Jiao Tong University School of Medicine 
Area:
Molecular Design
Website:
http://mdl.shsmu.edu.cn/
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39 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Shang JL, Ning SB, Chen YY, Chen TX, Zhang J. MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer. Acta Pharmacologica Sinica. PMID 32541922 DOI: 10.1038/S41401-020-0442-2  0.317
2020 Zhang X, Shi S, Su Y, Yang X, He S, Wu J, Zhang J, Rao F. Suramin and NF449 are IP5K inhibitors that disrupt IP6-mediated regulation of cullin RING ligase and sensitize cancer cells to MLN4924/pevonedistat. The Journal of Biological Chemistry. PMID 32493769 DOI: 10.1074/Jbc.Ra120.014375  0.35
2020 Shang J, Zhu Z, Chen Y, Song J, Huang Y, Song K, Zhong J, Xu X, Wei J, Wang C, Cui L, Liu CY, Zhang J. Small-molecule activating SIRT6 elicits therapeutic effects and synergistically promotes anti-tumor activity of vitamin D in colorectal cancer. Theranostics. 10: 5845-5864. PMID 32483423 DOI: 10.7150/Thno.44043  0.329
2020 Qin J, Shen X, Zhang J, Jia D. Allosteric inhibitors of the STAT3 signaling pathway. European Journal of Medicinal Chemistry. 190: 112122. PMID 32066011 DOI: 10.1016/J.Ejmech.2020.112122  0.311
2020 Lu S, Chen Y, Wei J, Zhao M, Ni D, He X, Zhang J. Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators Acta Pharmaceutica Sinica B. DOI: 10.1016/J.Apsb.2020.09.010  0.305
2019 Huang K, Liang Q, Zhou Y, Jiang LL, Gu WM, Luo MY, Tang YB, Wang Y, Lu W, Huang M, Zhang SZ, Zhuang GL, Dai Q, Shen QC, Zhang J, et al. A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer. Cell Metabolism. PMID 31607564 DOI: 10.1016/J.Cmet.2019.09.014  0.339
2019 Wang L, Zhang L, Li L, Jiang J, Zheng Z, Shang J, Wang C, Chen W, Bao Q, Xu X, Jiang Z, Zhang J, You Q. Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer. Science Advances. 5: eaax2277. PMID 31555737 DOI: 10.1126/Sciadv.Aax2277  0.306
2019 Yao H, Tang H, Zhang Y, Zhang QF, Liu XY, Liu YT, Gu WT, Zheng YZ, Shang HB, Wang Y, Huang JY, Wei YX, Zhang X, Zhang J, Wu ZB. DEPTOR inhibits cell proliferation and confers sensitivity to dopamine agonist in pituitary adenoma. Cancer Letters. PMID 31176743 DOI: 10.1016/J.Canlet.2019.05.043  0.309
2019 Xu X, Chen Y, Fu Q, Ni D, Zhang J, Li X, Lu S. The chemical diversity and structure-based discovery of allosteric modulators for the PIF-pocket of protein kinase PDK1. Journal of Enzyme Inhibition and Medicinal Chemistry. 34: 361-374. PMID 30734603 DOI: 10.1080/14756366.2018.1553167  0.302
2018 Yang X, Deng M, Zhang X, Song K, Ruan C, Meng L, Zhang J. Design, Synthesis, and Biological Evaluation of Thieno[3,2-d]pyrimidine Derivatives as Potential Simplified Phosphatidylinositol 3-Kinase alpha (PI3Kα) inhibitors. Chemical Biology & Drug Design. PMID 30381889 DOI: 10.1111/Cbdd.13425  0.339
2018 Yang X, Zhong J, Zhang Q, Qian J, Song K, Ruan C, Xu J, Ding K, Zhang J. Rational Design and Structure Validation of a Novel peptide Inhibitor of the Adenomatous Polyposis Coli (APC)-Rho Guanine Nucleotide Exchange Factor 4 (Asef) Interaction. Journal of Medicinal Chemistry. PMID 30095910 DOI: 10.1021/Acs.Jmedchem.8B01112  0.325
2018 Huang M, Song K, Liu X, Lu S, Shen Q, Wang R, Gao J, Hong Y, Li Q, Ni D, Xu J, Chen G, Zhang J. AlloFinder: a strategy for allosteric modulator discovery and allosterome analyses. Nucleic Acids Research. PMID 29757429 DOI: 10.1093/Nar/Gky374  0.3
2018 Chen Y, Li Z, Xu Z, Tang H, Guo W, Sun X, Zhang W, Zhang J, Wan X, Jiang Y, Mao Z. Use of the XRCC2 promoter for in vivo cancer diagnosis and therapy. Cell Death & Disease. 9: 420. PMID 29549248 DOI: 10.1038/S41419-018-0453-9  0.308
2017 Jiang HM, Dong JK, Song K, Wang TD, Huang WK, Zhang JM, Yang XY, Shen Y, Zhang J. A novel allosteric site in casein kinase 2α discovered using combining bioinformatics and biochemistry methods. Acta Pharmacologica Sinica. PMID 28748912 DOI: 10.1038/Aps.2017.55  0.305
2016 Huang M, Chen Z, Zhang L, Huang Z, Chen Y, Xu J, Zhang J, Shu X. Screening and biological evaluation of a novel STAT3 signaling pathway inhibitor against cancer. Bioorganic & Medicinal Chemistry Letters. PMID 27727126 DOI: 10.1016/J.Bmcl.2016.09.073  0.35
2016 Yang Y, Lu Y, Wang L, Mizokami A, Keller ET, Zhang J, Fu J. Skp2 is associated with paclitaxel resistance in prostate cancer cells. Oncology Reports. PMID 27175797 DOI: 10.3892/Or.2016.4809  0.4
2016 Shang J, Lu S, Jiang Y, Zhang J. Allosteric Modulators of MEK1: Drug design and Discovery. Chemical Biology & Drug Design. PMID 27115708 DOI: 10.1111/Cbdd.12780  0.306
2015 Hu Y, Li S, Liu F, Geng L, Shu X, Zhang J. Discovery of novel nonpeptide allosteric inhibitors interrupting the interaction of CDK2/cyclin A3 by virtual screening and bioassays. Bioorganic & Medicinal Chemistry Letters. PMID 26316466 DOI: 10.1016/J.Bmcl.2015.08.050  0.303
2015 Guo S, Huang W, Zhang J, Wang Y. Novel inhibitor against Malassezia globosa LIP1 (SMG1), a potential anti-dandruff target. Bioorganic & Medicinal Chemistry Letters. PMID 26199121 DOI: 10.1016/J.Bmcl.2015.07.005  0.311
2014 Uckun FM, Ma H, Ozer Z, Goodman P, Zhang J, Qazi S. A PREVIOUSLY UNKNOWN UNIQUE CHALLENGE FOR INHIBITORS OF SYK ATP-BINDING SITE: ROLE OF SYK AS A CELL CYCLE CHECKPOINT REGULATOR. Ebiomedicine. 1: 16-28. PMID 25506060 DOI: 10.1016/J.Ebiom.2014.10.019  0.315
2014 Zhao Y, Zhang X, Chen Y, Lu S, Peng Y, Wang X, Guo C, Zhou A, Zhang J, Luo Y, Shen Q, Ding J, Meng L, Zhang J. Crystal Structures of PI3Kα Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design. Acs Medicinal Chemistry Letters. 5: 138-42. PMID 24900786 DOI: 10.1021/Ml400378E  0.495
2014 Lu S, Li S, Zhang J. Harnessing Allostery: A Novel Approach to Drug Discovery Medicinal Research Reviews. 34: 1242-1285. PMID 24827416 DOI: 10.1002/Med.21317  0.305
2013 Huang Z, Mou L, Shen Q, Lu S, Li C, Liu X, Wang G, Li S, Geng L, Liu Y, Wu J, Chen G, Zhang J. ASD v2.0: updated content and novel features focusing on allosteric regulation. Nucleic Acids Research. 42: D510-6. PMID 24293647 DOI: 10.1093/Nar/Gkt1247  0.306
2012 Chen Y, Wen D, Huang Z, Huang M, Luo Y, Liu B, Lu H, Wu Y, Peng Y, Zhang J. 2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation. Bioorganic & Medicinal Chemistry Letters. 22: 6867-70. PMID 23044371 DOI: 10.1016/J.Bmcl.2012.09.037  0.5
2012 Lv M, Shi T, Mao X, Li X, Chen Y, Zhu J, Ni S, Shen X, Jiang H, Li J, Zhang J, Huang J. 1-(2,6-Dibenzyloxybenzoyl)-3-(9H-fluoren-9-yl)-urea: a novel cyclophilin A allosteric activator. Biochemical and Biophysical Research Communications. 425: 938-43. PMID 22906739 DOI: 10.1016/J.Bbrc.2012.08.014  0.302
2012 Zhang J, Wang J, Guo Q, Wang Y, Zhou Y, Peng H, Cheng M, Zhao D, Li F. LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells. Cancer Letters. 317: 24-32. PMID 22085492 DOI: 10.1016/J.Canlet.2011.11.007  0.31
2012 Zhang Z, Chen L, Gao L, Lin K, Zhu L, Lu Y, Shi X, Gao Y, Zhou J, Xu P, Zhang J, Wu G. Structural basis for the recognition of Asef by adenomatous polyposis coli. Cell Research. 22: 372-86. PMID 21788986 DOI: 10.1038/Cr.2011.119  0.315
2011 Wang F, Liu D, Wang H, Luo C, Zheng M, Liu H, Zhu W, Luo X, Zhang J, Jiang H. Computational screening for active compounds targeting protein sequences: methodology and experimental validation. Journal of Chemical Information and Modeling. 51: 2821-2828. PMID 21955088 DOI: 10.1021/Ci200264H  0.305
2011 Cai X, Zhang J, Chen M, Wu Y, Wang X, Chen J, Zhang J, Shen X, Qu D, Jiang H. The effect of the potential PhoQ histidine kinase inhibitors on Shigella flexneri virulence. Plos One. 6: e23100. PMID 21853073 DOI: 10.1371/Journal.Pone.0023100  0.311
2011 Huang Z, Zhu L, Cao Y, Wu G, Liu X, Chen Y, Wang Q, Shi T, Zhao Y, Wang Y, Li W, Li Y, Chen H, Chen G, Zhang J. ASD: a comprehensive database of allosteric proteins and modulators. Nucleic Acids Research. 39: D663-9. PMID 21051350 DOI: 10.1093/Nar/Gkq1022  0.309
2010 Chen J, Bai L, Bernard D, Nikolovska-Coleska Z, Gomez C, Zhang J, Yi H, Wang S. Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors. Acs Medicinal Chemistry Letters. 1: 85-89. PMID 20596242 DOI: 10.1021/Ml100010J  0.624
2009 Gomez C, Bai L, Zhang J, Nikolovska-Coleska Z, Chen J, Yi H, Wang S. Design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as STAT3 inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 1733-6. PMID 19243938 DOI: 10.1016/J.Bmcl.2009.01.091  0.61
2008 Chen J, Collins GT, Zhang J, Yang CY, Levant B, Woods J, Wang S. Design, synthesis, and evaluation of potent and selective ligands for the dopamine 3 (D3) receptor with a novel in vivo behavioral profile. Journal of Medicinal Chemistry. 51: 5905-8. PMID 18785726 DOI: 10.1021/Jm800471H  0.405
2008 Shangary S, Qin D, McEachern D, Liu M, Miller RS, Qiu S, Nikolovska-Coleska Z, Ding K, Wang G, Chen J, Bernard D, Zhang J, Lu Y, Gu Q, Shah RB, et al. Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition. Proceedings of the National Academy of Sciences of the United States of America. 105: 3933-8. PMID 18316739 DOI: 10.1073/Pnas.0708917105  0.549
2007 Han C, Zhang J, Chen L, Chen K, Shen X, Jiang H. Discovery of Helicobacter pylori shikimate kinase inhibitors: bioassay and molecular modeling. Bioorganic & Medicinal Chemistry. 15: 656-62. PMID 17098431 DOI: 10.1016/J.Bmc.2006.10.058  0.305
2006 Qin Z, Zhang J, Xu B, Chen L, Wu Y, Yang X, Shen X, Molin S, Danchin A, Jiang H, Qu D. Structure-based discovery of inhibitors of the YycG histidine kinase: new chemical leads to combat Staphylococcus epidermidis infections. Bmc Microbiology. 6: 96. PMID 17094812 DOI: 10.1186/1471-2180-6-96  0.31
2006 Li J, Zhang J, Chen J, Luo X, Zhu W, Shen J, Liu H, Shen X, Jiang H. Strategy for discovering chemical inhibitors of human cyclophilin a: focused library design, virtual screening, chemical synthesis and bioassay. Journal of Combinatorial Chemistry. 8: 326-37. PMID 16677001 DOI: 10.1021/Cc0501561  0.303
2005 Li J, Chen J, Gui C, Zhang L, Qin Y, Xu Q, Zhang J, Liu H, Shen X, Jiang H. Discovering novel chemical inhibitors of human cyclophilin A: virtual screening, synthesis, and bioassay. Bioorganic & Medicinal Chemistry. 14: 2209-24. PMID 16307882 DOI: 10.1016/J.Bmc.2005.11.006  0.323
2005 Chen G, Zheng S, Luo X, Shen J, Zhu W, Liu H, Gui C, Zhang J, Zheng M, Puah CM, Chen K, Jiang H. Focused combinatorial library design based on structural diversity, druglikeness and binding affinity score. Acs Combinatorial Science. 7: 398-406. PMID 15877468 DOI: 10.1021/Cc049866H  0.301
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