Arthur Melnick - Publications

Affiliations: 
University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
Area:
Philosophy

415 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Doane AS, Chu CS, Di Giammartino DC, Rivas MA, Hellmuth JC, Jiang Y, Yusufova N, Alonso A, Roeder RG, Apostolou E, Melnick AM, Elemento O. OCT2 pre-positioning facilitates cell fate transition and chromatin architecture changes in humoral immunity. Nature Immunology. PMID 34556886 DOI: 10.1038/s41590-021-01025-w  1
2021 Batra RN, Lifshitz A, Vidakovic AT, Chin SF, Sati-Batra A, Sammut SJ, Provenzano E, Ali HR, Dariush A, Bruna A, Murphy L, Purushotham A, Ellis I, Green A, Garrett-Bakelman FE, ... Melnick A, et al. DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation. Nature Communications. 12: 5406. PMID 34518533 DOI: 10.1038/s41467-021-25661-w  1
2021 Zee BM, Poels KE, Yao CH, Kawabata KC, Wu G, Duy C, Jacobus WD, Senior E, Endress JE, Jambhekar A, Lovitch SB, Ma J, Dhall A, Harris IS, Blanco MA, ... Melnick A, et al. Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia. Iscience. 24: 102651. PMID 34151238 DOI: 10.1016/j.isci.2021.102651  1
2021 Paietta E, Roberts KG, Wang V, Gu Z, Buck G, Pei D, Cheng C, Levine RL, Abdel-Wahab O, Cheng Z, Wu G, Qu C, Shi L, Pounds SB, Willman CL, ... Melnick A, et al. Molecular Classification Improves Risk Assessment in Adult BCR-ABL1-negative B-ALL. Blood. PMID 33895809 DOI: 10.1182/blood.2020010144  1
2021 Ai Y, Hwang L, MacKerell AD, Melnick A, Xue F. Progress toward B-Cell Lymphoma 6 BTB Domain Inhibitors for the Treatment of Diffuse Large B-Cell Lymphoma and Beyond. Journal of Medicinal Chemistry. PMID 33844535 DOI: 10.1021/acs.jmedchem.0c01686  1
2021 Mulet-Lazaro R, van Herk S, Erpelinck CAJ, Bindels E, Sanders MA, Vermeulen C, Renkens I, Valk P, Melnick A, de Ridder J, Rehli M, Gebhard C, Delwel R, Wouters BJ. Allele-specific expression of GATA2 due to epigenetic dysregulation in CEBPA double mutant AML. Blood. PMID 33831168 DOI: 10.1182/blood.2020009244  1
2021 Sevilla A, Papatsenko D, Mazloom AR, Xu H, Vasileva A, Unwin RD, LeRoy G, Chen EY, Garrett-Bakelman FE, Lee DF, Trinite B, Webb RL, Wang Z, Su J, Gingold J, Melnick A, et al. An Esrrb and Nanog Cell Fate Regulatory Module Controlled by Feed Forward Loop Interactions. Frontiers in Cell and Developmental Biology. 9: 630067. PMID 33816475 DOI: 10.3389/fcell.2021.630067  1
2021 Park J, Foox J, Hether T, Danko D, Warren S, Kim Y, Reeves J, Butler DJ, Mozsary C, Rosiene J, Shaiber A, Afshinnekoo E, MacKay M, Bram Y, Chandar V, ... Melnick AM, et al. Systemic Tissue and Cellular Disruption from SARS-CoV-2 Infection revealed in COVID-19 Autopsies and Spatial Omics Tissue Maps. Biorxiv : the Preprint Server For Biology. PMID 33758858 DOI: 10.1101/2021.03.08.434433  1
2021 Butler D, Mozsary C, Meydan C, Foox J, Rosiene J, Shaiber A, Danko D, Afshinnekoo E, MacKay M, Sedlazeck FJ, Ivanov NA, Sierra M, Pohle D, Zietz M, Gisladottir U, ... Melnick AM, et al. Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions. Nature Communications. 12: 1660. PMID 33712587 DOI: 10.1038/s41467-021-21361-7  1
2021 Carrasco-Leon A, Ezponda T, Meydan C, Valcárcel LV, Ordoñez R, Kulis M, Garate L, Miranda E, Segura V, Guruceaga E, Vilas-Zornoza A, Alignani D, Pascual M, Amundarain A, Castro-Labrador L, ... Melnick A, et al. Characterization of complete lncRNAs transcriptome reveals the functional and clinical impact of lncRNAs in multiple myeloma. Leukemia. PMID 33597729 DOI: 10.1038/s41375-021-01147-y  1
2021 Rapaport F, Neelamraju Y, Baslan T, Hassane D, Gruszczynska A, Robert de Massy M, Farnoud N, Haddox S, Lee T, Medina-Martinez J, Sheridan C, Thurmond A, Becker M, Bekiranov S, Carroll M, ... Melnick A, et al. Genomic and evolutionary portraits of disease relapse in acute myeloid leukemia. Leukemia. PMID 33580203 DOI: 10.1038/s41375-021-01153-0  1
2021 Mencia-Trinchant N, MacKay MJ, Chin C, Afshinnekoo E, Foox J, Meydan C, Butler D, Mozsary C, Vernice NA, Darby C, Schatz MC, Bailey SM, Melnick AM, Guzman ML, Bolton K, et al. Clonal hematopoiesis before, during, and after human spaceflight. Cell Reports. 34: 108740. PMID 33567281 DOI: 10.1016/j.celrep.2021.108740  1
2021 Kotlov N, Bagaev A, Revuelta MV, Phillip JM, Cacciapuoti MT, Antysheva Z, Svekolkin V, Tikhonova E, Miheecheva N, Kuzkina N, Nos G, Tabbo F, Frenkel F, Ghione P, Tsiper M, ... Melnick AM, et al. Clinical and biological subtypes of B-cell lymphoma revealed by microenvironmental signatures. Cancer Discovery. PMID 33541860 DOI: 10.1158/2159-8290.CD-20-0839  1
2021 Duy C, Li M, Teater M, Meydan C, Garrett-Bakelman FE, Lee TC, Chin CR, Durmaz C, Kawabata KC, Dhimolea E, Mitsiades CS, Doehner H, D'Andrea RJ, Becker MW, Paietta EM, ... Melnick AM, et al. Chemotherapy induces senescence-like resilient cells capable of initiating AML recurrence. Cancer Discovery. PMID 33500244 DOI: 10.1158/2159-8290.CD-20-1375  1
2021 Flümann R, Rehkämper T, Nieper P, Pfeiffer P, Holzem A, Klein S, Bhatia S, Kochanek M, Kisis I, Pelzer BW, Ahlert H, Hauer J, da Palma Guerreiro A, Ryan JA, Reimann M, ... Melnick AM, et al. An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities. Blood Cancer Discovery. 2: 70-91. PMID 33447829 DOI: 10.1158/2643-3230.BCD-19-0059  1
2021 Rivas MA, Meydan C, Chin CR, Challman MF, Kim D, Bhinder B, Kloetgen A, Viny AD, Teater MR, McNally DR, Doane AS, Béguelin W, Fernández MTC, Shen H, Wang X, ... Melnick AM, et al. Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation. Nature Immunology. PMID 33432228 DOI: 10.1038/s41590-020-00827-8  1
2021 Dhimolea E, de Matos Simoes R, Kansara D, Al'Khafaji A, Bouyssou J, Weng X, Sharma S, Raja J, Awate P, Shirasaki R, Tang H, Glassner BJ, Liu Z, Gao D, Bryan J, ... Melnick A, et al. An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence. Cancer Cell. PMID 33417832 DOI: 10.1016/j.ccell.2020.12.002  1
2020 Parsa S, Ortega-Molina A, Ying HY, Jiang M, Teater M, Wang J, Zhao C, Reznik E, Pasion JP, Kuo D, Mohan P, Wang S, Camarillo JM, Thomas PM, Jain N, ... Melnick AM, et al. The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing. Nature Cancer. 1: 653-664. PMID 33569544 DOI: 10.1038/s43018-020-0080-0  1
2020 Bezdan D, Grigorev K, Meydan C, Pelissier Vatter FA, Cioffi M, Rao V, MacKay M, Nakahira K, Burnham P, Afshinnekoo E, Westover C, Butler D, Mozsary C, Donahoe T, Foox J, ... Melnick AM, et al. Cell-free DNA (cfDNA) and Exosome Profiling from a Year-Long Human Spaceflight Reveals Circulating Biomarkers. Iscience. 23: 101844. PMID 33376973 DOI: 10.1016/j.isci.2020.101844  1
2020 Willcockson MA, Healton SE, Weiss CN, Bartholdy BA, Botbol Y, Mishra LN, Sidhwani DS, Wilson TJ, Pinto HB, Maron MI, Skalina KA, Toro LN, Zhao J, Lee CH, Hou H, ... Melnick AM, et al. H1 histones control the epigenetic landscape by local chromatin compaction. Nature. PMID 33299182 DOI: 10.1038/s41586-020-3032-z  0.08
2020 Yusufova N, Kloetgen A, Teater M, Osunsade A, Camarillo JM, Chin CR, Doane AS, Venters BJ, Portillo-Ledesma S, Conway J, Phillip JM, Elemento O, Scott DW, Béguelin W, Licht JD, ... Melnick AM, et al. Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture. Nature. PMID 33299181 DOI: 10.1038/s41586-020-3017-y  1
2020 Malkani S, Chin CR, Cekanaviciute E, Mortreux M, Okinula H, Tarbier M, Schreurs AS, Shirazi-Fard Y, Tahimic CGT, Rodriguez DN, Sexton BS, Butler D, Verma A, Bezdan D, Durmaz C, ... Melnick A, et al. Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development. Cell Reports. 108448. PMID 33242410 DOI: 10.1016/j.celrep.2020.108448  1
2020 Gertz ML, Chin CR, Tomoiaga D, MacKay M, Chang C, Butler D, Afshinnekoo E, Bezdan D, Schmidt MA, Mozsary C, Melnick A, Garrett-Bakelman F, Crucian B, Lee SMC, Zwart SR, et al. Multi-omic, Single-Cell, and Biochemical Profiles of Astronauts Guide Pharmacological Strategies for Returning to Gravity. Cell Reports. 108429. PMID 33242408 DOI: 10.1016/j.celrep.2020.108429  1
2020 Chu CS, Hellmuth JC, Singh R, Ying HY, Skrabanek L, Teater MR, Doane AS, Elemento O, Melnick AM, Roeder RG. Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage. Molecular Cell. PMID 33232656 DOI: 10.1016/j.molcel.2020.10.036  1
2020 Scholze H, Stephenson RE, Reynolds R, Shah S, Puri R, Butler SD, Trujillo-Alonso V, Teater MR, van Besien H, Gibbs-Curtis D, Ueno H, Parvin S, Letai A, Mathew S, Singh A, ... Melnick A, et al. Combined EZH2 and Bcl-2 inhibitors as precision therapy for genetically defined DLBCL subtypes. Blood Advances. 4: 5226-5231. PMID 33104794 DOI: 10.1182/bloodadvances.2020002580  1
2020 Abshiru NA, Sikora JW, Camarillo JM, Morris JA, Compton PD, Lee T, Neelamraju Y, Haddox S, Sheridan C, Carroll M, Cripe LD, Tallman MS, Paietta EM, Melnick AM, Thomas PM, et al. Targeted detection and quantitation of histone modifications from 1,000 cells. Plos One. 15: e0240829. PMID 33104722 DOI: 10.1371/journal.pone.0240829  1
2020 Li S, Chen X, Wang J, Meydan C, Glass JL, Shih AH, Delwel R, Levine RL, Mason CE, Melnick AM. Somatic mutations drive specific, but reversible epigenetic heterogeneity states in AML. Cancer Discovery. PMID 32938585 DOI: 10.1158/2159-8290.CD-19-0897  1
2020 Kawabata KC, Zong H, Meydan C, Wyman S, Wouters BJ, Sugita M, Goswami S, Albert M, Yip W, Roboz GJ, Chen Z, Delwel R, Carroll MP, Mason C, Melnick A, et al. BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells. Blood. PMID 32911532 DOI: 10.1182/Blood.2019001745  1
2020 Ordonez R, Kulis M, Russinol N, Chapaprieta V, Carrasco-Leon A, Garcia-Torre B, Charampopoulou S, Clot G, Beekman R, Meydan C, Duran-Ferrer M, Verdaguer-Dot N, Vilarrasa-Blasi R, Soler-Vila P, Garate L, ... Melnick A, et al. Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma. Genome Research. PMID 32820006 DOI: 10.1101/Gr.265520.120  1
2020 Fontan Gabas L, Goldstein RL, Casalena G, Durant M, Teater MR, Wilson J, Phillip JM, Xia M, Shah S, Us I, Shinglot H, Singh A, Inghirami GG, Melnick A. Identification of MALT1 Feedback Mechanisms Enables Rational Design of Potent Anti-Lymphoma Regimens for ABC-DLBCL. Blood. PMID 32785655 DOI: 10.1182/Blood.2019004713  1
2020 Venturutti L, Teater M, Zhai A, Chadburn A, Babiker L, Kim D, Béguelin W, Lee TC, Kim Y, Chin CR, Yewdell WT, Raught B, Phillip JM, Jiang Y, Staudt LM, ... Melnick AM, et al. TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate. Cell. PMID 32619424 DOI: 10.1016/J.Cell.2020.05.049  1
2020 Rosikiewicz W, Chen X, Dominguez PM, Ghamlouch H, Aoufouchi S, Bernard OA, Melnick A, Li S. TET2 deficiency reprograms the germinal center B cell epigenome and silences genes linked to lymphomagenesis. Science Advances. 6: eaay5872. PMID 32596441 DOI: 10.1126/Sciadv.Aay5872  1
2020 Butler DJ, Mozsary C, Meydan C, Danko D, Foox J, Rosiene J, Shaiber A, Afshinnekoo E, MacKay M, Sedlazeck FJ, Ivanov NA, Sierra M, Pohle D, Zietz M, Gisladottir U, ... Melnick AM, et al. Shotgun Transcriptome and Isothermal Profiling of SARS-CoV-2 Infection Reveals Unique Host Responses, Viral Diversification, and Drug Interactions. Biorxiv : the Preprint Server For Biology. PMID 32511352 DOI: 10.1101/2020.04.20.048066  1
2020 Béguelin W, Teater M, Meydan C, Hoehn KB, Phillip JM, Soshnev AA, Venturutti L, Rivas MA, Calvo-Fernández MT, Gutierrez J, Camarillo JM, Takata K, Tarte K, Kelleher NL, Steidl C, ... Melnick AM, et al. Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response. Cancer Cell. 37: 655-673.e11. PMID 32396861 DOI: 10.1016/J.Ccell.2020.04.004  1
2020 Mondello P, Tadros S, Teater M, Fontan L, Chang AY, Jain N, Yang H, Singh S, Ying HY, Chu CS, Ma MCJ, Toska E, Alig S, Durant M, de Stanchina E, ... Melnick AM, et al. Selective inhibition of HDAC3 targets synthetic vulnerabilities and activates immune surveillance in lymphoma. Cancer Discovery. PMID 31915197 DOI: 10.1158/2159-8290.Cd-19-0116  1
2020 MacKay M, Afshinnekoo E, Rub J, Hassan C, Khunte M, Baskaran N, Owens B, Liu L, Roboz GJ, Guzman ML, Melnick AM, Wu S, Mason CE. The therapeutic landscape for cells engineered with chimeric antigen receptors. Nature Biotechnology. PMID 31907405 DOI: 10.1038/S41587-019-0329-2  1
2019 Hellmuth JC, Chu CS, Singh R, Skrabanek LA, Doane A, Elemento O, Roeder RG, Melnick A. An OCT2 / OCA-B / MEF2B Ternary Complex Controls the Activity and Architecture of an Essential Locus Control Region for Normal and Malignant Germinal Center B-Cells. Blood. 134: 24. PMID 31723990 DOI: 10.1182/Blood-2019-130692  1
2019 Yusufova N, Teater MR, Soshnev A, Kloetgen A, Osunsade A, Conway J, Doane A, Skoultchi A, Tsirigos A, David Y, Allis CD, Cesarman E, Melnick A. Histone 1 Mutations Drive Lymphomagenesis By Inducing Primitive Stem Cell Functions and Epigenetic Instructions through Profound 3D Re-Organization of the B-Cell Genome. Blood. 134: 23. PMID 31723979 DOI: 10.1182/Blood-2019-127774  1
2019 Fong JY, Pignata L, Goy PA, Kawabata KC, Lee SC, Koh CM, Musiani D, Massignani E, Kotini AG, Penson A, Wun CM, Shen Y, Schwarz M, Low DH, Rialdi A, ... Melnick A, et al. Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation. Cancer Cell. 36: 194-209.e9. PMID 31408619 DOI: 10.1016/J.Ccell.2019.07.003  1
2019 Hurtz C, Chan LN, Geng H, Ballabio E, Xiao G, Deb G, Khoury H, Chen CW, Armstrong SA, Chen J, Ernst P, Melnick A, Milne T, Müschen M. Rationale for targeting BCL6 in -rearranged acute lymphoblastic leukemia. Genes & Development. PMID 31395741 DOI: 10.1101/Gad.327593.119  1
2019 Lu X, Chu CS, Fang T, Rayon-Estrada V, Fang F, Patke A, Qian Y, Clarke SH, Melnick AM, Zhang Y, Papavasiliou FN, Roeder RG. MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in Controlling the Pre-B to Immature B Cell Transition. Cell Reports. 28: 472-485.e5. PMID 31291582 DOI: 10.1016/J.Celrep.2019.06.029  1
2019 Li M, Chiang YL, Lyssiotis CA, Teater MR, Hong JY, Shen H, Wang L, Hu J, Jing H, Chen Z, Jain N, Duy C, Mistry SJ, Cerchietti L, Cross JR, ... Melnick AM, et al. Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis. Cancer Cell. 35: 916-931.e9. PMID 31185214 DOI: 10.1016/J.Ccell.2019.05.002  1
2019 Zhu B, Zhang R, Li C, Jiang L, Xiang M, Ye Z, Kita H, Melnick AM, Dent AL, Sun J. BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection. Proceedings of the National Academy of Sciences of the United States of America. PMID 31138703 DOI: 10.1073/Pnas.1902310116  1
2019 Scott DA, Hatcher JM, Liu H, Fu M, Du G, Fontán L, Us I, Casalena G, Qiao Q, Wu H, Melnick A, Gray NS. Quinoline and thiazolopyridine allosteric inhibitors of MALT1. Bioorganic & Medicinal Chemistry Letters. PMID 31129051 DOI: 10.1016/J.Bmcl.2019.05.040  1
2019 Duy C, Teater M, Garrett-Bakelman FE, Lee TC, Meydan C, Glass JL, Li M, Hellmuth JC, Mohammad HP, Smitheman KN, Shih AH, Abdel-Wahab O, Tallman MS, Guzman ML, Muench D, ... Melnick AM, et al. Rational targeting of cooperating layers of the epigenome yields enhanced therapeutic efficacy against AML. Cancer Discovery. PMID 31076479 DOI: 10.1158/2159-8290.Cd-19-0106  1
2019 Pastore A, Gaiti F, Lu SX, Brand RM, Kulm S, Chaligne R, Gu H, Huang KY, Stamenova EK, Béguelin W, Jiang Y, Schulman RC, Kim KT, Alonso A, Allan JN, ... Melnick AM, et al. Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL. Nature Communications. 10: 1874. PMID 31015400 DOI: 10.1038/S41467-019-09645-5  1
2019 Garrett-Bakelman FE, Darshi M, Green SJ, Gur RC, Lin L, Macias BR, McKenna MJ, Meydan C, Mishra T, Nasrini J, Piening BD, Rizzardi LF, Sharma K, Siamwala JH, Taylor L, ... Melnick AM, et al. The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. Science (New York, N.Y.). 364. PMID 30975860 DOI: 10.1126/Science.Aau8650  1
2019 Pascual M, Mena-Varas M, Robles EF, Garcia-Barchino MJ, Panizo C, Hervas-Stubbs S, Alignani D, Sagardoy A, Martínez JI, Bunting KL, Meier S, Sagaert X, Bagnara D, Guruceaga E, Blanco O, ... Melnick A, et al. PD-1/PD-L1 immune checkpoint and p53 loss facilitate tumor progression in activated B cell diffuse large B-cell lymphomas. Blood. PMID 30975638 DOI: 10.1182/Blood.2018889931  1
2019 Hatcher JM, Du G, Fontán L, Us I, Qiao Q, Chennamadhavuni S, Shao J, Wu H, Melnick A, Gray NS, Scott DA. Peptide-based covalent inhibitors of MALT1 paracaspase. Bioorganic & Medicinal Chemistry Letters. PMID 30954428 DOI: 10.1016/J.Bmcl.2019.03.046  1
2019 Goldman SL, MacKay M, Afshinnekoo E, Melnick AM, Wu S, Mason CE. The Impact of Heterogeneity on Single-Cell Sequencing. Frontiers in Genetics. 10: 8. PMID 30881372 DOI: 10.3389/fgene.2019.00008  1
2019 Mlynarczyk C, Fontán L, Melnick A. Germinal center-derived lymphomas: The darkest side of humoral immunity. Immunological Reviews. 288: 214-239. PMID 30874354 DOI: 10.1111/Imr.12755  1
2019 Agirre X, Meydan C, Jiang Y, Garate L, Doane AS, Li Z, Verma A, Paiva B, Martín-Subero JI, Elemento O, Mason CE, Prosper F, Melnick A. Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response. Nature Communications. 10: 821. PMID 30778059 DOI: 10.1038/S41467-019-08679-Z  1
2019 Fernando TM, Marullo R, Pera Gresely B, Phillip JM, Yang SN, Lundell-Smith G, Torregroza I, Ahn H, Evans T, Gyorffy B, Prive GG, Hirano M, Melnick AM, Cerchietti L. BCL6 evolved to enable stress tolerance in vertebrates and is broadly required by cancer cells to adapt to stress. Cancer Discovery. PMID 30777872 DOI: 10.1158/2159-8290.Cd-17-1444  1
2019 Ennishi D, Takata K, Beguelin W, Duns G, Mottok A, Farinha P, Bashashati A, Saberi S, Boyle M, Meissner B, Ben-Neriah S, Woolcock BW, Telenius A, Lai D, Teater M, ... Melnick AM, et al. Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition. Cancer Discovery. PMID 30705065 DOI: 10.1158/2159-8290.Cd-18-1090  1
2019 Hatzi K, Geng H, Doane AS, Meydan C, LaRiviere R, Cardenas M, Duy C, Shen H, Vidal MNC, Baslan T, Mohammad HP, Kruger RG, Shaknovich R, Haberman AM, Inghirami G, ... Melnick AM, et al. Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis. Nature Immunology. 20: 86-96. PMID 30538335 DOI: 10.1038/S41590-018-0273-1  1
2019 Saba NS, Meyers J, Fontan L, Melnick A, Wiestner A, Lobelle-Rich P, Kim E, Burger JA, Mouawad Y, Deininger PL, Socola F, Safah H, Flemington EK. The Paracaspase MALT1 Acts Independently of Pre-B-Cell Receptor Signaling As a Key Factor in Leukemic Cell Survival in Precursor B-Cell Acute Lymphoblastic Leukemia Blood. 134: 1288-1288. DOI: 10.1182/Blood-2019-131376  1
2019 Fontan L, Durant M, Goldstein R, Teater MR, Casalena G, Xia M, Wilson J, Us I, Inghirami G, Melnick A. Mapping MALT1 Signaling Connectivity Unveils Novel B-Cell Feedback Mechanisms Directing Assembly of Potent Anti-Lymphoma Regimens Blood. 134: 173-173. DOI: 10.1182/Blood-2019-130516  1
2019 Carrasco A, Ezponda T, Meydan C, Valcárcel LV, Ordoñez R, Kulis M, Garate L, Miranda E, Segura V, Guruceaga E, Vilas-Zornoza A, Alignani D, Castro L, Pascual M, Amundarain A, ... Melnick AM, et al. Characterization of Complete Lncrnas Transcriptome Reveals Expression of Lncrnas As a Prognostic Factor and Linc-Smilo As a Potential Therapeutic Target in Multiple Myeloma Blood. 134: 4323-4323. DOI: 10.1182/Blood-2019-123008  1
2019 Carrasco-Leon A, Ezponda T, Meydan C, Valcárcel LV, Ordoñez R, Kulis M, Garate L, Miranda E, Segura V, Guruceaga E, Vilas-Zornoza A, Alignani D, Castro-Labrador L, Pascual M, Amundarain A, ... Melnick A, et al. Role of lncRNAs as prognostic factor and potential therapeutic target in Multiple Myeloma Clinical Lymphoma, Myeloma & Leukemia. 19. DOI: 10.1016/J.Clml.2019.09.585  1
2018 Dominguez PM, Ghamlouch H, Rosikiewicz W, Kumar P, Béguelin W, Fontan L, Rivas MA, Pawlikowska P, Armand M, Mouly E, Torres-Martin M, Doane AS, Calvo Fernandez MT, Durant M, Della-Valle V, ... Melnick AM, et al. TET2 deficiency causes germinal center hyperplasia, impairs plasma cell differentiation and promotes B-cell lymphomagenesis. Cancer Discovery. PMID 30274972 DOI: 10.1158/2159-8290.Cd-18-0657  1
2018 Lu X, Fernando T, Lossos C, Yusufova N, Liu F, Fontán L, Durant M, Geng H, Melnick J, Luo Y, Vega F, Moy V, Inghirami G, Nimer S, Melnick AM, et al. PRMT5 interacts with the BCL6 oncoprotein and is required for germinal center formation and lymphoma cell survival. Blood. PMID 30082494 DOI: 10.1182/Blood-2018-02-831438  1
2018 Purwada A, Shah SB, Béguelin W, August A, Melnick AM, Singh A. Ex vivo synthetic immune tissues with T cell signals for differentiating antigen-specific, high affinity germinal center B cells. Biomaterials. PMID 30041943 DOI: 10.1016/J.Biomaterials.2018.06.034  1
2018 Fontán L, Qiao Q, Hatcher JM, Casalena G, Us I, Teater M, Durant M, Du G, Xia M, Bilchuk N, Chennamadhavuni S, Palladino G, Inghirami G, Philippar U, Wu H, ... Melnick A, et al. Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth. The Journal of Clinical Investigation. PMID 30024860 DOI: 10.1172/Jci99436  1
2018 Cheng H, Linhares B, Yu W, Cardenas MG, Ai Y, Jiang W, Winkler A, Cohen S, Melnick A, MacKerell AD, Cierpicki T, Xue F. Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 (BCL6) BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design. Journal of Medicinal Chemistry. PMID 29969259 DOI: 10.1021/Acs.Jmedchem.8B00040  1
2018 Apoorva F, Loiben AM, Shah SB, Purwada A, Fontan L, Goldstein R, Kirby BJ, Melnick AM, Cosgrove BD, Singh A. How Biophysical Forces Regulate Human B Cell Lymphomas. Cell Reports. 23: 499-511. PMID 29642007 DOI: 10.1016/j.celrep.2018.03.069  1
2018 Noh KM, Wang H, Kim HR, Wenderski W, Fang F, Li CH, Dewell S, Hughes SH, Melnick AM, Patel DJ, Li H, Allis CD. Engineering of a Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs. Molecular Cell. 69: 533. PMID 29395070 DOI: 10.1016/j.molcel.2018.01.014  1
2018 Teater M, Dominguez PM, Redmond D, Chen Z, Ennishi D, Scott DW, Cimmino L, Ghione P, Chaudhuri J, Gascoyne RD, Aifantis I, Inghirami G, Elemento O, Melnick A, Shaknovich R. AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis. Nature Communications. 9: 222. PMID 29335468 DOI: 10.1038/S41467-017-02595-W  1
2018 Mondello P, Teater M, Fontan L, Durant M, Stanchina Ed, Inghirami G, Green M, Melnick A. Abstract 797: Targeting HDAC3 reactivates immunosurveillance and enhances immunocheckpoint activity in B-cell lymphoma Cancer Research. 78: 797-797. DOI: 10.1158/1538-7445.Am2018-797  1
2018 Lee J, Geng H, Chen Z, Xiao G, Cosgun KN, Zammarchi F, Berkel PV, Melnick A, Paietta E, Muschen M. Abstract 2983: CD25 enables oncogenic BCR- and TCR-signaling and represents a therapeutic target in lymphoblastic malignancies Cancer Research. 78: 2983-2983. DOI: 10.1158/1538-7445.Am2018-2983  1
2017 Purwada A, Shah SB, Beguelin W, Melnick AM, Singh A. Modular Immune Organoids with Integrin Ligand Specificity Differentially Regulate Ex Vivo B Cell Activation. Acs Biomaterials Science & Engineering. 3: 214-225. PMID 33450794 DOI: 10.1021/acsbiomaterials.6b00474  1
2017 Kunimoto H, Meydan C, Nazir A, Whitfield J, Shank K, Rapaport F, Maher R, Pronier E, Meyer SC, Garrett-Bakelman FE, Tallman M, Melnick A, Levine RL, Shih AH. Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity. Cancer Cell. PMID 29275866 DOI: 10.1016/J.Ccell.2017.11.012  1
2017 Li Y, Huang X, Huang S, He H, Lei T, Saaoud F, Yu XQ, Melnick A, Kumar A, Papasian CJ, Fan D, Fu M. Central role of myeloid MCPIP1 in protecting against LPS-induced inflammation and lung injury. Signal Transduction and Targeted Therapy. 2: 17066. PMID 29263935 DOI: 10.1038/Sigtrans.2017.66  1
2017 Béguelin W, Rivas MA, Calvo Fernández MT, Teater M, Purwada A, Redmond D, Shen H, Challman MF, Elemento O, Singh A, Melnick AM. EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop. Nature Communications. 8: 877. PMID 29026085 DOI: 10.1038/S41467-017-01029-X  1
2017 Saba NS, Wong DH, Tanios G, Iyer JR, Lobelle-Rich P, Dadashian EL, Liu D, Fontan L, Flemington EK, Nichols CM, Underbayev C, Safah H, Melnick A, Wiestner A, Herman SEM. MALT1 inhibition is efficacious in both naïve and ibrutinib-resistant chronic lymphocytic leukemia. Cancer Research. PMID 28993409 DOI: 10.1158/0008-5472.Can-17-2485  1
2017 Teater M, Melnick A. Untangling the Web of Lymphoma Somatic Mutations. Cell. 171: 270-272. PMID 28985559 DOI: 10.1016/J.Cell.2017.09.031  1
2017 Vu LP, Pickering BF, Cheng Y, Zaccara S, Nguyen D, Minuesa G, Chou T, Chow A, Saletore Y, MacKay M, Schulman J, Famulare C, Patel M, Klimek VM, Garrett-Bakelman FE, Melnick A, et al. The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nature Medicine. PMID 28920958 DOI: 10.1038/Nm.4416  1
2017 Oricchio E, Katanayeva N, Donaldson MC, Sungalee S, Joyce PP, Béguelin W, Battistello E, Sanghvi VR, Jiang M, Jiang Y, Teater M, Parmigiani A, Budanov AV, Chan FC, Shah SP, ... Melnick AM, et al. Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma. Science Translational Medicine. 9. PMID 28659443 DOI: 10.1126/Scitranslmed.Aak9969  1
2017 Vu LP, Prieto C, Amin EM, Chhangawala S, Krivtsov A, Calvo-Vidal MN, Chou T, Chow A, Minuesa G, Park SM, Barlowe TS, Taggart J, Tivnan P, Deering RP, Chu LP, ... Melnick A, et al. Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells. Nature Genetics. PMID 28436985 DOI: 10.1038/Ng.3854  1
2017 Glass J, Hassane DC, Wouters B, Kunimoto H, Avellino R, Garrett-Bakelman FE, Guryanova OA, Bowman R, Redlich S, Intlekofer A, Meydan C, Qin T, Fall MP, Alonso A, Guzman ML, ... Melnick A, et al. Epigenetic Identity in AML Depends on Disruption of Non-promoter Regulatory Elements and is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers. Cancer Discovery. PMID 28408400 DOI: 10.1158/2159-8290.Cd-16-1032  1
2017 Gascoyne RD, Nadel B, Pasqualucci L, Fitzgibbon J, Payton JE, Melnick A, Weigert O, Tarte K, Gribben JG, Friedberg JW, Seymour JF, Cavalli F, Zucca E. Follicular lymphoma: State-of-the-art ICML workshop in Lugano 2015. Hematological Oncology. PMID 28378425 DOI: 10.1002/Hon.2411  1
2017 Valls E, Lobry C, Geng H, Wang L, Cardenas M, Rivas M, Cerchietti L, Oh P, Yang SN, Oswald E, Graham CW, Jiang Y, Hatzi K, Agirre X, Perkey E, ... Melnick A, et al. BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells. Cancer Discovery. PMID 28232365 DOI: 10.1158/2159-8290.Cd-16-1189  1
2017 Shih AH, Meydan C, Shank K, Garrett-Bakelman FE, Ward PS, Intlekofer A, Nazir A, Stein E, Knapp K, Glass J, Travins J, Straley K, Gliser C, Mason C, Yen K, ... Melnick A, et al. Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia. Cancer Discovery. PMID 28193779 DOI: 10.1158/2159-8290.Cd-16-1049  1
2017 Du W, Goldstein R, Jiang Y, Aly O, Cerchietti L, Melnick AM, Elemento O. Effective combination therapies for B cell lymphoma predicted by a virtual disease model. Cancer Research. PMID 28130226 DOI: 10.1158/0008-5472.Can-16-0476  1
2017 Chung SS, Eng WS, Hu W, Khalaj M, Garrett-Bakelman FE, Tavakkoli M, Levine RL, Carroll M, Klimek VM, Melnick AM, Park CY. CD99 is a therapeutic target on disease stem cells in myeloid malignancies. Science Translational Medicine. 9. PMID 28123069 DOI: 10.1126/Scitranslmed.Aaj2025  1
2017 Cerchietti L, Melnick A. DNA Methylation-Based Biomarkers. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2016710616. PMID 28113009 DOI: 10.1200/Jco.2016.71.0616  1
2017 Kunimoto H, McKenney AS, Meydan C, Shank K, Nazir A, Rapaport F, Durham B, Garrett-Bakelman FE, Pronier E, Shih AH, Melnick A, Chaudhuri J, Levine RL. Aid is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells. Blood. PMID 28077417 DOI: 10.1182/Blood-2016-06-721977  1
2017 Li M, Chiang Y, Lyssiotis C, Teater M, Shen H, Wang L, Hong JY, Jin H, Duy C, Mistry S, Cerchietti L, Cross J, Cantley L, Lin H, Melnick A. SIRT3 Is a Novel Metabolic Driver of and Therapeutic Target for Chemotherapy Resistant Dlbcls Blood. 130: 643-643. DOI: 10.1182/Blood.V130.Suppl_1.643.643  1
2017 Vu L, Prieto C, Amin EM, Minuesa G, Chhangawala S, Vidal MC, Krivtsov A, Chou T, Chow A, Barlowe T, Taggart J, Tivnan P, Deering RP, Chu LP, Gonen M, ... Melnick A, et al. Abstract IA13: RNA regulators and the control of self-renewal Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Hemmal17-Ia13  1
2017 Fachel AA, Jiang Y, Tam W, Muley AS, Meydan C, Agirre X, Melnick AM, Richards KL. Abstract 30: SOX9 enhancer regulator may play an oncogenic role in B-cell lymphomas Clinical Cancer Research. 23: 30-30. DOI: 10.1158/1557-3265.Hemmal17-30  1
2017 Fontan L, Scott D, Hatcher J, Qiao Q, Us I, Casalena G, Bekkers M, Philippar U, Durant M, Chennamadhavuni S, Wu H, Gray N, Melnick A. Abstract LB-303: Substrate-mimetic covalent inhibitor of MALT1 is most effective against CARD11 mutant ABC-DLBCL Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-303  1
2017 Venneti S, Bayliss J, Mukherjee P, Lu C, Jain S, Chung C, Martinez D, Sabari B, Margol A, Panwalkar P, Paroloia A, Pekmezci M, Eachin RM, Cieslik M, Tamrazi B, ... Melnick A, et al. Abstract 3863: A subset of poorly prognostic pediatric posterior fossa ependymomas exhibit lowered H3K27me3 and DNA hypomethylation and show epigenetic similarities with H3K27M mutant diffuse intrinsic pontine gliomas Cancer Research. 77: 3863-3863. DOI: 10.1158/1538-7445.Am2017-3863  1
2016 Rimsza L, Fedoriw Y, Staudt LM, Melnick A, Gascoyne R, Crump M, Baizer L, Fu K, Hsi E, Chan JW, McShane L, Leonard JP, Kahl BS, Little RF, Friedberg JW, et al. General Biomarker Recommendations for Lymphoma. Journal of the National Cancer Institute. 108. PMID 27986882 DOI: 10.1093/Jnci/Djw250  1
2016 Bayliss J, Mukherjee P, Lu C, Jain SU, Chung C, Martinez D, Sabari B, Margol AS, Panwalkar P, Parolia A, Pekmezci M, McEachin RC, Cieslik M, Tamrazi B, Garcia BA, ... Melnick A, et al. Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas. Science Translational Medicine. 8: 366ra161. PMID 27881822 DOI: 10.1126/Scitranslmed.Aah6904  1
2016 Cardenas MG, Oswald E, Yu W, Xue F, MacKerell AD, Melnick AM. The expanding role of the BCL6 oncoprotein as a cancer therapeutic target. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27881582 DOI: 10.1158/1078-0432.Ccr-16-2071  1
2016 Guryanova OA, Shank K, Spitzer B, Luciani L, Koche RP, Garrett-Bakelman FE, Ganzel C, Durham BH, Mohanty A, Hoermann G, Rivera SA, Chramiec AG, Pronier E, Bastian L, Keller MD, ... Melnick AM, et al. DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling. Nature Medicine. PMID 27841873 DOI: 10.1038/Nm.4210  1
2016 Nandi S, Chandramohan D, Fioriti L, Melnick AM, Hébert JM, Mason CE, Rajasethupathy P, Kandel ER. Roles for small noncoding RNAs in silencing of retrotransposons in the mammalian brain. Proceedings of the National Academy of Sciences of the United States of America. PMID 27791114 DOI: 10.1073/pnas.1609287113  1
2016 Jiang Y, Ortega-Molina A, Geng H, Ying HY, Hatzi K, Parsa S, McNally D, Wang L, Doane AS, Agirre Ena X, Teater M, Meydan C, Li Z, Poloway D, Wang S, ... Melnick AM, et al. CREBBP Inactivation Promotes the Development of HDAC3 Dependent Lymphomas. Cancer Discovery. PMID 27733359 DOI: 10.1158/2159-8290.Cd-16-0975  1
2016 Rodina A, Wang T, Yan P, Gomes ED, Dunphy MP, Pillarsetty N, Koren J, Gerecitano JF, Taldone T, Zong H, Caldas-Lopes E, Alpaugh M, Corben A, Riolo M, Beattie B, ... Melnick A, et al. The epichaperome is an integrated chaperome network that facilitates tumour survival. Nature. PMID 27706135 DOI: 10.1038/Nature19807  1
2016 Bunting KL, Soong TD, Singh R, Jiang Y, Béguelin W, Poloway DW, Swed BL, Hatzi K, Reisacher W, Teater M, Elemento O, Melnick AM. Multi-tiered Reorganization of the Genome during B Cell Affinity Maturation Anchored by a Germinal Center-Specific Locus Control Region. Immunity. PMID 27637145 DOI: 10.1016/J.Immuni.2016.08.012  1
2016 Béguelin W, Teater M, Gearhart MD, Calvo Fernández MT, Goldstein RL, Cárdenas MG, Hatzi K, Rosen M, Shen H, Corcoran CM, Hamline MY, Gascoyne RD, Levine RL, Abdel-Wahab O, Licht JD, ... ... Melnick AM, et al. EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis. Cancer Cell. 30: 197-213. PMID 27505670 DOI: 10.1016/J.Ccell.2016.07.006  1
2016 Fiskus W, Coothankandaswamy V, Chen J, Ma H, Ha K, Saenz DT, Krieger SS, Mill CP, Sun B, Huang P, Mumm JS, Melnick A, Bhalla KN. SIRT2 deacetylates and inhibits the peroxidase activity of peroxiredoxin-1 to sensitize breast cancer cells to oxidant stress inducing agents. Cancer Research. PMID 27503926 DOI: 10.1158/0008-5472.Can-16-0126  1
2016 Cardenas MG, Yu W, Beguelin W, Teater MR, Geng H, Goldstein RL, Oswald E, Hatzi K, Yang SN, Cohen J, Shaknovich R, Vanommeslaeghe K, Cheng H, Liang D, Cho HJ, ... Melnick AM, et al. Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma. The Journal of Clinical Investigation. PMID 27482887 DOI: 10.1172/Jci85795  1
2016 Han D, Lu X, Shih AH, Nie J, You Q, Xu MM, Melnick AM, Levine RL, He C. A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations. Molecular Cell. PMID 27477909 DOI: 10.1016/J.Molcel.2016.06.028  1
2016 Luskin MR, Gimotty PA, Smith C, Loren AW, Figueroa ME, Harrison J, Sun Z, Tallman MS, Paietta EM, Litzow MR, Melnick AM, Levine RL, Fernandez HF, Luger SM, Carroll M, et al. A clinical measure of DNA methylation predicts outcome in de novo acute myeloid leukemia. Jci Insight. 1. PMID 27446991 DOI: 10.1172/Jci.Insight.87323  1
2016 Garrett-Bakelman FE, Melnick AM. Mutant IDH: a targetable driver of leukemic phenotypes linking metabolism, epigenetics and transcriptional regulation. Epigenomics. PMID 27431380 DOI: 10.2217/epi-2016-0008  1
2016 Carrion A, García-Cruz E, Fernandez C, D'Anna M, Melnick A, Peri L, Franco A, Alcaraz A. Prior Lubrication of the Urethra Does Not Reduce Pain Perception in Men Undergoing Flexible Cystoscopy. Urologia Internationalis. PMID 27376907 DOI: 10.1159/000447497  1
2016 Li S, Garrett-Bakelman FE, Chung SS, Sanders MA, Hricik T, Rapaport F, Patel J, Dillon R, Vijay P, Brown AL, Perl AE, Cannon J, Bullinger L, Luger S, Becker M, ... ... Melnick AM, et al. Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia. Nature Medicine. PMID 27322744 DOI: 10.1038/Nm.4125  1
2016 Robles EF, Mena-Varas M, Barrio L, Merino-Cortes SV, Balogh P, Du MQ, Akasaka T, Parker A, Roa S, Panizo C, Martin-Guerrero I, Siebert R, Segura V, Agirre X, Macri-Pellizeri L, ... ... Melnick AM, et al. Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics. Nature Communications. 7: 11889. PMID 27297662 DOI: 10.1038/ncomms11889  1
2016 LaFave LM, Béguelin W, Koche R, Teater M, Spitzer B, Chramiec A, Papalexi E, Keller MD, Hricik T, Konstantinoff K, Micol JB, Durham B, Knutson SK, Campbell JE, Blum G, ... ... Melnick A, et al. Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status". Nature Medicine. 22: 578-579. PMID 27270773 DOI: 10.1038/Nm.4094  1
2016 Melnick AL, Rdesinski RE, Marino M, Jacob-Files E, Gipson T, Kuyl M, Dexter E, Olds D. Randomized Controlled Trial of Home-Based Hormonal Contraceptive Dispensing for Women At Risk of Unintended Pregnancy. Perspectives On Sexual and Reproductive Health. PMID 27196986 DOI: 10.1363/48e9816  1
2016 Murphy EM, Pereira N, Melnick AP, Spandorfer SD. Spontaneous bilateral torsion of fallopian tubes presenting as primary infertility. Women's Health (London, England). PMID 27167412 DOI: 10.2217/whe.16.2  1
2016 Li S, Mason C, Melnick A. Genetic and epigenetic heterogeneity in acute myeloid leukemia. Current Opinion in Genetics & Development. 36: 100-106. PMID 27162099 DOI: 10.1016/J.Gde.2016.03.011  1
2016 Kang HJ, Melnick AP, Stewart JD, Xu K, Rosenwaks Z. Preimplantation genetic screening: who benefits? Fertility and Sterility. PMID 27143516 DOI: 10.1016/j.fertnstert.2016.04.027  1
2016 Saba NS, Liu D, Herman SE, Underbayev C, Tian X, Behrend D, Weniger MA, Skarzynski M, Gyamfi J, Fontan L, Melnick A, Grant C, Roschewski M, Navarro A, Beà S, et al. Pathogenic role of B-cell receptor signaling and canonical NF-κB activation in mantle cell lymphoma. Blood. PMID 27127301 DOI: 10.1182/Blood-2015-11-681460  1
2016 Gheorghita S, Birca L, Donos A, Wasley A, Birca I, Cojocaru R, Melnick A, Ciobanu S, Mosina L, Cortese MM, Parashar UD, Lopman B. Impact of Rotavirus Vaccine Introduction and Vaccine Effectiveness in the Republic of Moldova. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 62: S140-6. PMID 27059348 DOI: 10.1093/cid/civ1209  1
2016 Jiang Y, Dominguez PM, Melnick A. The many layers of epigenetic dysfunction in B-cell lymphomas. Current Opinion in Hematology. PMID 27055146 DOI: 10.1097/Moh.0000000000000249  1
2016 Meyer SE, Qin T, Muench DE, Masuda K, Venkatasubramanian M, Orr E, Suarez L, Gore SD, Delwel R, Paietta E, Tallman MS, Fernandez H, Melnick A, Le Beau MM, Kogan S, et al. Dnmt3a haploinsufficiency transforms Flt3-ITD myeloproliferative disease into a rapid, spontaneous, and fully-penetrant acute myeloid leukemia. Cancer Discovery. PMID 27016502 DOI: 10.1158/2159-8290.Cd-16-0008  1
2016 Shojaee S, Chan LN, Buchner M, Cazzaniga V, Cosgun KN, Geng H, Qiu YH, von Minden MD, Ernst T, Hochhaus A, Cazzaniga G, Melnick A, Kornblau SM, Graeber TG, Wu H, et al. PTEN opposes negative selection and enables oncogenic transformation of pre-B cells. Nature Medicine. PMID 26974310 DOI: 10.1038/Nm.4062  1
2016 Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, et al. Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. PMID 26958840 DOI: 10.1038/Nature16997  1
2016 Kozloski GA, Jiang X, Bhatt S, Ruiz J, Vega F, Shaknovich R, Melnick A, Lossos IS. MiR-181a negatively regulates NF-κB signaling and affects activated B-cell like diffuse large B-cell lymphoma pathogenesis. Blood. PMID 26941399 DOI: 10.1182/Blood-2015-11-680462  1
2016 Melnick AP, Pereira N, Murphy EM, Rosenwaks Z, Spandorfer SD. How low is too low? Cycle day 28 estradiol levels and pregnancy outcomes. Fertility and Sterility. 105: 905-909.e1. PMID 26707516 DOI: 10.1016/j.fertnstert.2015.11.046  1
2016 Vilaseca A, Musquera M, Nguyen DP, Di Paola G, Romeo LR, Melnick A, García-Cruz E, Ribal MJ, Huguet J, Alcaraz A. Changing patterns in the surgical management of renal masses. Actas Urologicas Espanolas. 40: 148-154. PMID 26687094 DOI: 10.1016/j.acuro.2015.08.009  1
2016 Fontan L, Goldstein R, Casalena G, Shinglot H, Us I, Ju H, Jiang Y, Bilchuk N, Melnick A. RNA Interference Screen Implicates TNFAIP3 and FOXO1 in MALT1 Inhibition Resistance Blood. 128: 837-837. DOI: 10.1182/Blood.V128.22.837.837  1
2016 Ying H, Jiang Y, Ortega-Molina A, Geng H, McNally D, Wang L, Doane A, Agirre X, Ju H, Poloway D, Teater M, Parsa S, Ennishi D, Scott DW, Shaknovich R, ... Melnick A, et al. Crebbp Mutations Disrupt Dynamic Enhancer Acetylation in B-Cells, Enabling HDAC3 to Drive Lymphomagenesis Blood. 128: 735-735. DOI: 10.1182/Blood.V128.22.735.735  1
2016 Duy C, Teater M, Garrett-Bakelman FE, Carroll M, Melnick A. Acute Myeloid Leukemia Cells Resist Chemotherapy through a Reversible Senescence-like State Maintaining Repopulation Potential Blood. 128: 582-582. DOI: 10.1182/Blood.V128.22.582.582  1
2016 Fachel AA, Muley AS, Meydan C, Agirre X, Cerchietti L, Melnick A, Richards KL. Targeting ß-Catenin Signaling in DLBCL with ICG-001 and PAM-1 Suppresses Cell Proliferation and Induces Apoptosis Blood. 128: 5382-5382. DOI: 10.1182/Blood.V128.22.5382.5382  1
2016 Carrasco A, Ezponda T, Meydan C, Kulis M, Ordoñez R, Garate L, Segura V, Alignani D, Paiva B, Miguel JS, Subero JIM, Melnick A, Prosper F, Agirre X. Long Non-Coding RNAs Annotation and Their Involvement in Multiple Myeloma Blood. 128: 4420-4420. DOI: 10.1182/Blood.V128.22.4420.4420  1
2016 Samaraweera SE, Garrett-Bakelman FE, Neelamraju Y, Perugini M, Casolari DA, Iarossi D, Bray SC, Sheridan C, Lee TC, Tiong IS, Danner S, Cummings N, Guzman ML, Roboz GJ, To LB, ... Melnick A, et al. Hypermethylation of GADD45A Defines a Methylation Profile Distinct to Mutant IDH1/2, and Correlates with More Aggressive AML Blood. 128: 2877-2877. DOI: 10.1182/Blood.V128.22.2877.2877  1
2016 Duy C, Teater M, Garrett-Bakelman FE, Lee TC, Meydan C, Glass JL, Li M, Mohammad H, Smitheman K, Shih AH, Abdel-Wahab O, Paietta E, Tallman MS, Guzman ML, Kruger RG, ... Melnick A, et al. Cooperative Gene Repression By DNA Methylation and LSD1-Mediated Enhancer Inactivation in Acute Myeloid Leukemia Blood. 128: 1048-1048. DOI: 10.1182/Blood.V128.22.1048.1048  1
2016 Ortega-Molina A, Boss IW, Canela A, Pan H, Jiang Y, Zhao C, Jiang M, Hu D, Lee J, Chen H, Ennishi D, Scott DW, Hother C, Liu S, Cao X, ... ... Melnick AM, et al. Abstract IA18: Functional characterization of the tumor suppressor lysine-specific methyltransferase KMT2D in lymphoma Cancer Research. 76. DOI: 10.1158/1538-7445.Chromepi15-Ia18  1
2016 Li S, Garrett-Bakelman FE, Chung SS, Hricik T, Rapaport F, Patel J, Dillon R, Vijay P, Brown AL, Perl AE, Connon J, Sanders MA, Valk PJM, Bullinger L, Luger S, ... Melnick AM, et al. Abstract LB-073: Epigenome evolution in relapsed acute myeloid leukemia Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-073  1
2016 Marullo R, Ahn H, Cardenas M, Melnick A, Xue F, Cerchietti L. Abstract 1271: The transcription factor BCL6 is a rational target in non-small cell lung cancer (NSCLC) Cancer Research. 76: 1271-1271. DOI: 10.1158/1538-7445.Am2016-1271  1
2016 Gheorghita S, Birca L, Donos A, Wasley A, Birca I, Cojocaru R, Melnick A, Ciobanu S, Mosina L, Cortese MM, Parashar UD, Lopman B. Impact of Rotavirus Vaccine Introduction and Vaccine Effectiveness in the Republic of Moldova Clinical Infectious Diseases. 62: S140-S146. DOI: 10.1093/cid/civ1209  1
2015 Jiang Y, Nie K, Redmond D, Melnick AM, Tam W, Elemento O. VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma. Journal of Visualized Experiments : Jove. PMID 26780364 DOI: 10.3791/53215  1
2015 Guryanova OA, Lieu YK, Garrett-Bakelman FE, Spitzer B, Glass JL, Shank K, Martinez AB, Rivera SA, Durham BH, Rapaport F, Keller MD, Pandey S, Bastian L, Tovbin D, Weinstein AR, ... ... Melnick AM, et al. Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells. Leukemia. PMID 26710888 DOI: 10.1038/leu.2015.358  1
2015 Dupont T, Yang S, Patel J, Hatzi K, Malik A, Tam W, Martin P, Leonard J, Melnick A, Cerchietti L. Selective targeting of BCL6 induces oncogene addiction switching to BCL2 in B-cell lymphoma. Oncotarget. PMID 26657288 DOI: 10.18632/Oncotarget.6513  1
2015 Zong H, Gozman A, Caldas-Lopes E, Taldone T, Sturgill E, Brennan S, Ochiana SO, Gomes-DaGama EM, Sen S, Rodina A, Koren J, Becker MW, Rudin CM, Melnick A, Levine RL, et al. A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species. Cell Reports. PMID 26628369 DOI: 10.1016/J.Celrep.2015.10.073  1
2015 Culjkovic-Kraljacic B, Fernando TM, Marullo R, Calvo-Vidal N, Verma A, Yang S, Tabbò F, Gaudiano M, Zahreddine H, Goldstein RL, Patel J, Taldone T, Chiosis G, Ladetto M, Ghione P, ... ... Melnick A, et al. Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas. Blood. PMID 26603836 DOI: 10.1182/Blood-2015-05-645069  1
2015 Huang C, Melnick A. Mechanisms of action of BCL6 during germinal center B cell development. Science China. Life Sciences. PMID 26566802 DOI: 10.1007/S11427-015-4919-Z  1
2015 Goldstein RL, Yang SN, Taldone T, Chang B, Gerecitano J, Elenitoba-Johnson K, Shaknovich R, Tam W, Leonard JP, Chiosis G, Cerchietti L, Melnick A. Pharmacoproteomics identifies combinatorial therapy targets for diffuse large B cell lymphoma. The Journal of Clinical Investigation. 2015. PMID 26529251 DOI: 10.1172/Jci80714  1
2015 Verma A, Jiang Y, Du W, Fairchild L, Melnick A, Elemento O. Transcriptome sequencing reveals thousands of novel long non-coding RNAs in B cell lymphoma. Genome Medicine. 7: 110. PMID 26521025 DOI: 10.1182/Blood.V126.23.2427.2427  1
2015 Viny AD, Ott CJ, Spitzer B, Rivas M, Meydan C, Papalexi E, Yelin D, Shank K, Reyes J, Chiu A, Romin Y, Boyko V, Thota S, Maciejewski JP, Melnick A, et al. Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis. The Journal of Experimental Medicine. 212: 1819-32. PMID 26438361 DOI: 10.1182/Blood.V126.23.435.435  1
2015 LaFave LM, Béguelin W, Koche R, Teater M, Spitzer B, Chramiec A, Papalexi E, Keller MD, Hricik T, Konstantinoff K, Micol JB, Durham B, Knutson SK, Campbell JE, Blum G, ... ... Melnick A, et al. Loss of BAP1 function leads to EZH2-dependent transformation. Nature Medicine. PMID 26437366 DOI: 10.1038/Nm.3947  1
2015 Tian YF, Ahn H, Schneider RS, Yang SN, Roman-Gonzalez L, Melnick AM, Cerchietti L, Singh A. Integrin-specific hydrogels as adaptable tumor organoids for malignant B and T cells. Biomaterials. 73: 110-119. PMID 26406451 DOI: 10.1016/j.biomaterials.2015.09.007  1
2015 Ortega-Molina A, Boss IW, Canela A, Pan H, Jiang Y, Zhao C, Jiang M, Hu D, Agirre X, Niesvizky I, Lee JE, Chen HT, Ennishi D, Scott DW, Mottok A, ... ... Melnick AM, et al. The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development. Nature Medicine. PMID 26366710 DOI: 10.1038/Nm.3943  1
2015 Dominguez PM, Teater M, Chambwe N, Kormaksson M, Redmond D, Ishii J, Vuong B, Chaudhuri J, Melnick A, Vasanthakumar A, Godley LA, Papavasiliou FN, Elemento O, Shaknovich R. DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID. Cell Reports. 12: 2086-98. PMID 26365193 DOI: 10.1016/J.Celrep.2015.08.036  1
2015 Noh KM, Wang H, Kim HR, Wenderski W, Fang F, Li CH, Dewell S, Hughes SH, Melnick AM, Patel DJ, Li H, Allis CD. Engineering of a Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs. Molecular Cell. 59: 89-103. PMID 26073541 DOI: 10.1016/J.Molcel.2015.05.017  1
2015 Shojaee S, Caeser R, Buchner M, Park E, Swaminathan S, Hurtz C, Geng H, Chan LN, Klemm L, Hofmann WK, Qiu YH, Zhang N, Coombes KR, Paietta E, Molkentin J, ... ... Melnick A, et al. Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia. Cancer Cell. 28: 114-28. PMID 26073130 DOI: 10.1016/J.Ccell.2015.05.008  1
2015 Boss IW, Melnick AM. VII. Are lymphomas driven by epigenetic lesions? Hematological Oncology. 33: 42-5. PMID 26062053 DOI: 10.1002/hon.2215  1
2015 Melnick AP, Murphy EM, Masbou AK, Sapra KJ, Rosenwaks Z, Spandorfer SD. Autologous endometrial coculture biopsy: Is timing everything? Fertility and Sterility. 104: 104-109.e1. PMID 25989976 DOI: 10.1016/j.fertnstert.2015.04.026  1
2015 Pereira N, Brauer AA, Melnick AP, Lekovich JP, Spandorfer SD. Prognostic value of growth of 4-cell embryos on the day of transfer in fresh IVF-ET cycles. Journal of Assisted Reproduction and Genetics. 32: 939-43. PMID 25925346 DOI: 10.1007/s10815-015-0478-2  1
2015 Pan H, Jiang Y, Boi M, Tabbò F, Redmond D, Nie K, Ladetto M, Chiappella A, Cerchietti L, Shaknovich R, Melnick AM, Inghirami GG, Tam W, Elemento O. Epigenomic evolution in diffuse large B-cell lymphomas. Nature Communications. 6: 6921. PMID 25891015 DOI: 10.1182/Blood.V122.21.634.634  1
2015 Shih AH, Jiang Y, Meydan C, Shank K, Pandey S, Barreyro L, Antony-Debre I, Viale A, Socci N, Sun Y, Robertson A, Cavatore M, de Stanchina E, Hricik T, Rapaport F, ... ... Melnick A, et al. Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia. Cancer Cell. 27: 502-15. PMID 25873173 DOI: 10.1016/J.Ccell.2015.03.009  1
2015 Hatzi K, Nance JP, Kroenke MA, Bothwell M, Haddad EK, Melnick A, Crotty S. BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms. The Journal of Experimental Medicine. 212: 539-53. PMID 25824819 DOI: 10.1084/Jem.20141380  1
2015 Weinstock DM, Dalla-Favera R, Gascoyne RD, Leonard JP, Levy R, Lossos IS, Melnick AM, Nowakowski GS, Press OW, Savage KJ, Shipp MA, Staudt LM. A roadmap for discovery and translation in lymphoma. Blood. 125: 2175-7. PMID 25814490 DOI: 10.1182/Blood-2015-01-623777  1
2015 Jiang Y, Melnick A. The epigenetic basis of diffuse large B-cell lymphoma. Seminars in Hematology. 52: 86-96. PMID 25805588 DOI: 10.1053/J.Seminhematol.2015.01.003  1
2015 Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, et al. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 521: 357-61. PMID 25799995 DOI: 10.1038/Nature14231  1
2015 Geng H, Hurtz C, Lenz KB, Chen Z, Baumjohann D, Thompson S, Goloviznina NA, Chen WY, Huan J, LaTocha D, Ballabio E, Xiao G, Lee JW, Deucher A, Qi Z, ... ... Melnick A, et al. Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia. Cancer Cell. 27: 409-25. PMID 25759025 DOI: 10.1016/J.Ccell.2015.02.003  1
2015 Buchner M, Park E, Geng H, Klemm L, Flach J, Passegué E, Schjerven H, Melnick A, Paietta E, Kopanja D, Raychaudhuri P, Müschen M. Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia. Nature Communications. 6: 6471. PMID 25753524 DOI: 10.1038/Ncomms7471  1
2015 Garrett-Bakelman FE, Sheridan CK, Kacmarczyk TJ, Ishii J, Betel D, Alonso A, Mason CE, Figueroa ME, Melnick AM. Enhanced reduced representation bisulfite sequencing for assessment of DNA methylation at base pair resolution. Journal of Visualized Experiments : Jove. e52246. PMID 25742437 DOI: 10.3791/52246  1
2015 Park SM, Gönen M, Vu L, Minuesa G, Tivnan P, Barlowe TS, Taggart J, Lu Y, Deering RP, Hacohen N, Figueroa ME, Paietta E, Fernandez HF, Tallman MS, Melnick A, et al. Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program. The Journal of Clinical Investigation. 125: 1286-98. PMID 25664853 DOI: 10.1172/Jci78440  1
2015 Chen L, Chen W, Mysliwski M, Serio J, Ropa J, Abulwerdi FA, Chan RJ, Patel JP, Tallman MS, Paietta E, Melnick A, Levine RL, Abdel-Wahab O, Nikolovska-Coleska Z, Muntean AG. Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition. Leukemia. 29: 1290-300. PMID 25650089 DOI: 10.1038/Leu.2015.18  1
2015 Agirre X, Castellano G, Pascual M, Heath S, Kulis M, Segura V, Bergmann A, Esteve A, Merkel A, Raineri E, Agueda L, Blanc J, Richardson D, Clarke L, Datta A, ... ... Melnick A, et al. Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers. Genome Research. 25: 478-87. PMID 25644835 DOI: 10.1016/J.Clml.2015.07.243  1
2015 Van der Meulen J, Sanghvi V, Mavrakis K, Durinck K, Fang F, Matthijssens F, Rondou P, Rosen M, Pieters T, Vandenberghe P, Delabesse E, Lammens T, De Moerloose B, Menten B, Van Roy N, ... ... Melnick AM, et al. The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia. Blood. 125: 13-21. PMID 25320243 DOI: 10.1182/blood-2014-05-577270  1
2015 Kuo PY, Leshchenko VV, Fazzari MJ, Perumal D, Gellen T, He T, Iqbal J, Baumgartner-Wennerholm S, Nygren L, Zhang F, Zhang W, Suh KS, Goy A, Yang DT, Chan WC, ... ... Melnick AM, et al. High-resolution chromatin immunoprecipitation (ChIP) sequencing reveals novel binding targets and prognostic role for SOX11 in mantle cell lymphoma. Oncogene. 34: 1231-40. PMID 24681958 DOI: 10.1038/Onc.2014.44  1
2015 Walker SR, Liu S, Xiang M, Nicolais M, Hatzi K, Giannopoulou E, Elemento O, Cerchietti L, Melnick A, Frank DA. The transcriptional modulator BCL6 as a molecular target for breast cancer therapy. Oncogene. 34: 1073-82. PMID 24662818 DOI: 10.1038/Onc.2014.61  1
2015 Kraljacic-Culkjovic B, Fernando T, Goldstein R, Mctavish C, Patel J, Yang S, Tabbo F, Melnick A, Inghirami G, Borden KL, Cerchietti L. Abstract B12: EIF4E deregulation drives simultaneous expression of B-cell lymphoma oncogenes. Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Hemmal14-B12  1
2015 Fontan L, Yang C, Shinglot H, Kabaleeswaran V, Laurent V, Osborne M, Beltran E, Rosen M, Shaknovich R, Yang SN, Gascoyne RD, Cerchietti L, MArtinez-Climent JA, Glickman JF, Borden K, ... Melnick A, et al. Abstract A19: MALT1 inhibition as an anchor for combinatorial therapy of ABC-DLBCL. Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Hemmal14-A19  1
2015 Ortega-Molina A, Boss I, Pan H, Jiang Y, Hu D, Gao X, Shaknovich R, Shilatifard A, Melnick AM, Wendel H. Abstract LB-064: Characterization of the tumor suppressor function of the lysine-specific methyltransferase KMT2D in follicular lymphoma Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Lb-064  1
2015 Rodina AA, Taldone T, Kang Y, Patel P, Koren J, Yan P, Gomes ED, Yang C, Patel M, Shrestha L, Ochiana S, Maharaj R, Gozman A, Cox M, Erdjument-Bromage H, ... Melnick A, et al. Abstract 1733: Development of chemical tools to study the endogenous Hsp70 interactome in malignant cells Cancer Research. 75: 1733-1733. DOI: 10.1158/1538-7445.Am2015-1733  1
2015 Melnick AP, Pereira N, Murphy EM, Rosenwaks Z, Spandorfer SD. How low is too low? Cycle day 28 estradiol levels and pregnancy outcomes Fertility and Sterility. DOI: 10.1016/j.fertnstert.2015.11.046  1
2015 Vilaseca A, Musquera M, Nguyen DP, Di Paola G, Romeo LR, Melnick A, García-Cruz E, Ribal MJ, Huguet J, Alcaraz A. Changing patterns in the surgical management of renal masses Actas Urologicas Espanolas. DOI: 10.1016/j.acuro.2015.08.009  1
2015 Boss IW, Melnick AM. VII. Are lymphomas driven by epigenetic lesions? Hematological Oncology. 33: 42-45. DOI: 10.1002/hon.2215  1
2014 Rampal R, Alkalin A, Madzo J, Vasanthakumar A, Pronier E, Patel J, Li Y, Ahn J, Abdel-Wahab O, Shih A, Lu C, Ward PS, Tsai JJ, Hricik T, Tosello V, ... ... Melnick A, et al. DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia. Cell Reports. 9: 1841-55. PMID 25482556 DOI: 10.1016/J.Celrep.2014.11.004  1
2014 Melnick A. Impact of the single accreditation agreement on GME governance and the physician workforce Journal of the American Osteopathic Association. 114: e120-e121. PMID 25352412 DOI: 10.7556/jaoa.2014.168  1
2014 Patel RG, Purwada A, Cerchietti L, Inghirami G, Melnick A, Gaharwar AK, Singh A. Microscale Bioadhesive Hydrogel Arrays for Cell Engineering Applications. Cellular and Molecular Bioengineering. 7: 394-408. PMID 25328548 DOI: 10.1007/S12195-014-0353-8  1
2014 Li S, Garrett-Bakelman F, Perl AE, Luger SM, Zhang C, To BL, Lewis ID, Brown AL, D'Andrea RJ, Ross ME, Levine R, Carroll M, Melnick A, Mason CE. Dynamic evolution of clonal epialleles revealed by methclone. Genome Biology. 15: 472. PMID 25260792 DOI: 10.1186/S13059-014-0472-5  1
2014 Jacob-Files E, Rdesinski R, Storey M, Gipson T, Cohen DJ, Olds D, Melnick A. Should Home-Based Contraceptive Dispensing become a Routine part of Public Health Nurse Practice? Review of Nurse Perceptions. Public Health Nursing (Boston, Mass.). PMID 25196399 DOI: 10.1111/phn.12150  1
2014 Huang C, Gonzalez DG, Cote CM, Jiang Y, Hatzi K, Teater M, Dai K, Hla T, Haberman AM, Melnick A. The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers. Cell Reports. 8: 1497-508. PMID 25176650 DOI: 10.1016/J.Celrep.2014.07.059  1
2014 Jiang Y, Redmond D, Nie K, Eng KW, Clozel T, Martin P, Tan LH, Melnick AM, Tam W, Elemento O. Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas. Genome Biology. 15: 432. PMID 25123191 DOI: 10.1186/s13059-014-0432-0  1
2014 Ha K, Fiskus W, Choi DS, Bhaskara S, Cerchietti L, Devaraj SG, Shah B, Sharma S, Chang JC, Melnick AM, Hiebert S, Bhalla KN. Histone deacetylase inhibitor treatment induces 'BRCAness' and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells. Oncotarget. 5: 5637-50. PMID 25026298 DOI: 10.18632/Oncotarget.2154  1
2014 Rodina A, Taldone T, Kang Y, Patel PD, Koren J, Yan P, DaGama Gomes EM, Yang C, Patel MR, Shrestha L, Ochiana SO, Santarossa C, Maharaj R, Gozman A, Cox MB, ... ... Melnick A, et al. Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer. Acs Chemical Biology. 9: 1698-705. PMID 24934503 DOI: 10.1021/Cb500256U  1
2014 Green MR, Vicente-Dueñas C, Romero-Camarero I, Long Liu C, Dai B, González-Herrero I, García-Ramírez I, Alonso-Escudero E, Iqbal J, Chan WC, Campos-Sanchez E, Orfao A, Pintado B, Flores T, Blanco O, ... ... Melnick A, et al. Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma. Nature Communications. 5: 3904. PMID 24887457 DOI: 10.1038/Ncomms4904  1
2014 Chung SS, Kim E, Park JH, Chung YR, Lito P, Teruya-Feldstein J, Hu W, Beguelin W, Monette S, Duy C, Rampal R, Telis L, Patel M, Kim MK, Huberman K, ... ... Melnick AM, et al. Hematopoietic stem cell origin of BRAFV600E mutations in hairy cell leukemia. Science Translational Medicine. 6: 238ra71. PMID 24871132 DOI: 10.1126/Scitranslmed.3008004  1
2014 Kharabi Masouleh B, Geng H, Hurtz C, Chan LN, Logan AC, Chang MS, Huang C, Swaminathan S, Sun H, Paietta E, Melnick AM, Koeffler P, Müschen M. Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia. Proceedings of the National Academy of Sciences of the United States of America. 111: E2219-28. PMID 24821775 DOI: 10.1073/Pnas.1400958111  1
2014 Kemp CJ, Moore JM, Moser R, Bernard B, Teater M, Smith LE, Rabaia NA, Gurley KE, Guinney J, Busch SE, Shaknovich R, Lobanenkov VV, Liggitt D, Shmulevich I, Melnick A, et al. CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer. Cell Reports. 7: 1020-9. PMID 24794443 DOI: 10.1016/J.Celrep.2014.04.004  1
2014 Merte JL, Kroll CM, Collins AS, Melnick AL. An epidemiologic investigation of occupational transmission of Mycobacterium tuberculosis infection to dental health care personnel: infection prevention and control implications. Journal of the American Dental Association (1939). 145: 464-71. PMID 24789240 DOI: 10.14219/jada.2013.52  1
2014 Hatzi K, Melnick A. Breaking bad in the germinal center: How deregulation of BCL6 contributes to lymphomagenesis Trends in Molecular Medicine. 20: 343-352. PMID 24698494 DOI: 10.1016/J.Molmed.2014.03.001  1
2014 Taskesen E, Havermans M, van Lom K, Sanders MA, van Norden Y, Bindels E, Hoogenboezem R, Reinders MJ, Figueroa ME, Valk PJ, Löwenberg B, Melnick A, Delwel R. Two splice-factor mutant leukemia subgroups uncovered at the boundaries of MDS and AML using combined gene expression and DNA-methylation profiling. Blood. 123: 3327-35. PMID 24668493 DOI: 10.1182/Blood-2013-07-512855  1
2014 Prebet T, Sun Z, Figueroa ME, Ketterling R, Melnick A, Greenberg PL, Herman J, Juckett M, Smith MR, Malick L, Paietta E, Czader M, Litzow M, Gabrilove J, Erba HP, et al. Prolonged administration of azacitidine with or without entinostat for myelodysplastic syndrome and acute myeloid leukemia with myelodysplasia-related changes: results of the US Leukemia Intergroup trial E1905. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 32: 1242-8. PMID 24663049 DOI: 10.1200/Jco.2013.50.3102  1
2014 Fiskus W, Saba N, Shen M, Ghias M, Liu J, Gupta SD, Chauhan L, Rao R, Gunewardena S, Schorno K, Austin CP, Maddocks K, Byrd J, Melnick A, Huang P, et al. Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia. Cancer Research. 74: 2520-32. PMID 24599128 DOI: 10.1158/0008-5472.Can-13-2033  1
2014 Bartholdy B, Christopeit M, Will B, Mo Y, Barreyro L, Yu Y, Bhagat TD, Okoye-Okafor UC, Todorova TI, Greally JM, Levine RL, Melnick A, Verma A, Steidl U. HSC commitment-associated epigenetic signature is prognostic in acute myeloid leukemia. The Journal of Clinical Investigation. 124: 1158-67. PMID 24487588 DOI: 10.1172/Jci71264  1
2014 Chambwe N, Kormaksson M, Geng H, De S, Michor F, Johnson NA, Morin RD, Scott DW, Godley LA, Gascoyne RD, Melnick A, Campagne F, Shaknovich R. Variability in DNA methylation defines novel epigenetic subgroups of DLBCL associated with different clinical outcomes. Blood. 123: 1699-708. PMID 24385541 DOI: 10.1182/Blood-2013-07-509885  1
2014 Huang C, Geng H, Boss I, Wang L, Melnick A. Cooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation Blood. 123: 1012-1020. PMID 24277074 DOI: 10.1182/Blood-2013-07-518605  1
2014 Oyer JA, Huang X, Zheng Y, Shim J, Ezponda T, Carpenter Z, Allegretta M, Okot-Kotber CI, Patel JP, Melnick A, Levine RL, Ferrando A, Mackerell AD, Kelleher NL, Licht JD, et al. Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies. Leukemia. 28: 198-201. PMID 23823660 DOI: 10.1038/Leu.2013.204  1
2014 Du W, Goldstein R, Jiang Y, Aly O, Cerchietti L, Melnick AM, Elemento O. A Virtual B Cell Lymphoma Model to Predict Effective Combination Therapy Blood. 124: 928-928. DOI: 10.1182/Blood.V124.21.928.928  1
2014 Park E, Swaminathan S, Sadiyah MF, Igarashi K, Melnick A, Muschen M. BACH2 promotes Lineage-Specific Fate Decisions in BCR-ABL1-Driven Leukemia Blood. 124: 513-513. DOI: 10.1182/Blood.V124.21.513.513  1
2014 Hatzi K, Nance JP, Kroenke M, Haddad EK, Melnick AM, Crotty S. BCL6 Orchestrates Tfh Differentiation Via Multiple Distinct Mechanisms Blood. 124: 4137-4137. DOI: 10.1182/Blood.V124.21.4137.4137  1
2014 Agirre X, Castellano G, Pascual M, Kulis M, Segura V, Bergmann A, Esteve A, Merkel A, Raineri E, Agueda L, Blanc J, Richardson D, Clarke L, Russiñol N, Queirós AC, ... Melnick AM, et al. Whole-genome epigenomic analysis in multiple myeloma reveals DNA hypermethylation of b-cell specific enhancers Blood. 124: 2032-2032. DOI: 10.1182/Blood.V124.21.2032.2032  1
2014 Beguelin W, Teater M, Popovic R, Jiang Y, Cerchietti L, Shaknovich R, Gascoyne R, Levine R, Abdel-Wahab O, Licht J, Elemento O, Melnick AM. Abstract SY09-03: How deregulation of histone methyltransferases drive malignant transformation of B-cells Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Sy09-03  1
2014 Cardenas MG, Teater MR, Calvo-Vidal N, Yang SN, Glickman JF, Melnick A, Cerchietti L. Abstract 4232: Small molecule phenotypic targeting of aggressive B-cell lymphomas Cancer Research. 74: 4232-4232. DOI: 10.1158/1538-7445.Am2014-4232  1
2014 Kim E, Chung SS, Park JH, Chung YR, Lito P, Feldstein J, Hu W, Beguilin W, Monette S, Duy C, Rampal R, Telis L, Patel M, Kim MK, Melnick AM, et al. Abstract 3140: Context specific effects of the BRAFV600E mutation on hematopoiesis identifies novel models of BRAF mutant hematopoietic disorders Cancer Research. 74: 3140-3140. DOI: 10.1158/1538-7445.Am2014-3140  1
2014 Fontan L, Yang C, Kabaleeswaran V, Volpon L, Osborne M, Beltran E, Rosen M, Shaknovich R, Yang SN, Gascoyne RD, Cerchietti L, Martinez-Climent JA, Glickman JF, Borden K, Wu H, Melnick A, et al. Abstract 2693: Harnessing MALT1 inhibition for rational combinatorial therapy of ABC-DLBCL Cancer Research. 74: 2693-2693. DOI: 10.1158/1538-7445.Am2014-2693  1
2014 Broxmeyer HE, Melnick AM. Editorial introductions Current Opinion in Hematology. 21: v-vi. DOI: 10.1097/MOH.0000000000000065  1
2014 Will B, Todorova T, Verma A, Steidl U, Melnick A. Regulation of hematopoietic stem cell fate by special at-rich sequence binding protein 1 Experimental Hematology. 42. DOI: 10.1016/J.Exphem.2014.07.251  1
2013 Vu LP, Perna F, Wang L, Voza F, Figueroa ME, Tempst P, Erdjument-Bromage H, Gao R, Chen S, Paietta E, Deblasio T, Melnick A, Liu Y, Zhao X, Nimer SD. PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex. Cell Reports. 5: 1625-38. PMID 24332853 DOI: 10.1016/J.Celrep.2013.11.025  1
2013 Olds D, Donelan-McCall N, O'Brien R, MacMillan H, Jack S, Jenkins T, Dunlap WP, O'Fallon M, Yost E, Thorland B, Pinto F, Gasbarro M, Baca P, Melnick A, Beeber L. Improving the nurse-family partnership in community practice. Pediatrics. 132: S110-7. PMID 24187112 DOI: 10.1542/Peds.2013-1021I  1
2013 Di Ruscio A, Ebralidze AK, Benoukraf T, Amabile G, Goff LA, Terragni J, Figueroa ME, De Figueiredo Pontes LL, Alberich-Jorda M, Zhang P, Wu M, D'Alò F, Melnick A, Leone G, Ebralidze KK, et al. DNMT1-interacting RNAs block gene-specific DNA methylation. Nature. 503: 371-6. PMID 24107992 DOI: 10.1038/Nature12598  1
2013 Qiao Q, Yang C, Zheng C, Fontán L, David L, Yu X, Bracken C, Rosen M, Melnick A, Egelman EH, Wu H. Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly. Molecular Cell. 51: 766-79. PMID 24074955 DOI: 10.1016/J.Molcel.2013.08.032  1
2013 Lu C, Venneti S, Akalin A, Fang F, Ward PS, Dematteo RG, Intlekofer AM, Chen C, Ye J, Hameed M, Nafa K, Agaram NP, Cross JR, Khanin R, Mason CE, ... ... Melnick A, et al. Induction of sarcomas by mutant IDH2. Genes & Development. 27: 1986-98. PMID 24065766 DOI: 10.1101/Gad.226753.113  1
2013 Lai AY, Mav D, Shah R, Grimm SA, Phadke D, Hatzi K, Melnick A, Geigerman C, Sobol SE, Jaye DL, Wade PA. DNA methylation profiling in human B cells reveals immune regulatory elements and epigenetic plasticity at Alu elements during B-cell activation. Genome Research. 23: 2030-41. PMID 24013550 DOI: 10.1101/Gr.155473.113  1
2013 Fontán L, Melnick A. Molecular pathways: Targeting MALT1 paracaspase activity in lymphoma Clinical Cancer Research. 19: 6662-6668. PMID 24004675 DOI: 10.1158/1078-0432.Ccr-12-3869  1
2013 Cerchietti L, Melnick A. Targeting BCL6 in diffuse large B-cell lymphoma: What does this mean for the future treatment? Expert Review of Hematology. 6: 343-345. PMID 23991920 DOI: 10.1586/17474086.2013.826928  1
2013 Clozel T, Yang S, Elstrom RL, Tam W, Martin P, Kormaksson M, Banerjee S, Vasanthakumar A, Culjkovic B, Scott DW, Wyman S, Leser M, Shaknovich R, Chadburn A, Tabbo F, ... ... Melnick A, et al. Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma. Cancer Discovery. 3: 1002-19. PMID 23955273 DOI: 10.1158/2159-8290.Cd-13-0117  1
2013 Nayar U, Lu P, Goldstein RL, Vider J, Ballon G, Rodina A, Taldone T, Erdjument-Bromage H, Chomet M, Blasberg R, Melnick A, Cerchietti L, Chiosis G, Wang YL, Cesarman E. Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies. Blood. 122: 2837-47. PMID 23943653 DOI: 10.1182/Blood-2013-01-479972  1
2013 Figueroa ME, Chen SC, Andersson AK, Phillips LA, Li Y, Sotzen J, Kundu M, Downing JR, Melnick A, Mullighan CG. Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia. The Journal of Clinical Investigation. 123: 3099-111. PMID 23921123 DOI: 10.1172/Jci66203  1
2013 Hatzi K, Jiang Y, Huang C, Garrett-Bakelman F, Gearhart MD, Giannopoulou EG, Zumbo P, Kirouac K, Bhaskara S, Polo JM, Kormaksson M, MacKerell AD, Xue F, Mason CE, Hiebert SW, ... ... Melnick A, et al. A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters. Cell Reports. 4: 578-88. PMID 23911289 DOI: 10.1016/J.Celrep.2013.06.016  1
2013 Swaminathan S, Huang C, Geng H, Chen Z, Harvey R, Kang H, Ng C, Titz B, Hurtz C, Sadiyah MF, Nowak D, Thoennissen GB, Rand V, Graeber TG, Koeffler HP, ... ... Melnick A, et al. BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint. Nature Medicine. 19: 1014-22. PMID 23852341 DOI: 10.1038/Nm.3247  1
2013 Santini V, Melnick A, Maciejewski JP, Duprez E, Nervi C, Cocco L, Ford KG, Mufti G. Epigenetics in focus: pathogenesis of myelodysplastic syndromes and the role of hypomethylating agents. Critical Reviews in Oncology/Hematology. 88: 231-45. PMID 23838480 DOI: 10.1016/J.Critrevonc.2013.06.004  1
2013 Sun XJ, Wang Z, Wang L, Jiang Y, Kost N, Soong TD, Chen WY, Tang Z, Nakadai T, Elemento O, Fischle W, Melnick A, Patel DJ, Nimer SD, Roeder RG. A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis. Nature. 500: 93-7. PMID 23812588 DOI: 10.1038/Nature12287  1
2013 Bertolo C, Roa S, Sagardoy A, Mena-Varas M, Robles EF, Martinez-Ferrandis JI, Sagaert X, Tousseyn T, Orta A, Lossos IS, Amar S, Natkunam Y, Briones J, Melnick A, Malumbres R, et al. LITAF, a BCL6 target gene, regulates autophagy in mature B-cell lymphomas. British Journal of Haematology. 162: 621-30. PMID 23795761 DOI: 10.1111/Bjh.12440  1
2013 Li S, Garrett-Bakelman FE, Akalin A, Zumbo P, Levine R, To BL, Lewis ID, Brown AL, D'Andrea RJ, Melnick A, Mason CE. An optimized algorithm for detecting and annotating regional differential methylation. Bmc Bioinformatics. 14: S10. PMID 23735126 DOI: 10.1186/1471-2105-14-S5-S10  1
2013 Garrett-Bakelman FE, Melnick AM. Differentiation therapy for IDH1/2 mutant malignancies. Cell Research. 23: 975-7. PMID 23732524 DOI: 10.1038/cr.2013.73  1
2013 Bunting KL, Melnick AM. New effector functions and regulatory mechanisms of BCL6 in normal and malignant lymphocytes Current Opinion in Immunology. 25: 339-346. PMID 23725655 DOI: 10.1016/j.coi.2013.05.003  1
2013 Béguelin W, Popovic R, Teater M, Jiang Y, Bunting KL, Rosen M, Shen H, Yang SN, Wang L, Ezponda T, Martinez-Garcia E, Zhang H, Zheng Y, Verma SK, McCabe MT, ... ... Melnick AM, et al. EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. Cancer Cell. 23: 677-92. PMID 23680150 DOI: 10.1016/J.Ccr.2013.04.011  1
2013 Fontan L, Melnick A. Discovering what makes STAT signaling TYK in T-ALL Cancer Discovery. 3: 494-496. PMID 23658297 DOI: 10.1158/2159-8290.Cd-13-0123  1
2013 Ruan J, Luo M, Wang C, Fan L, Yang SN, Cardenas M, Geng H, Leonard JP, Melnick A, Cerchietti L, Hajjar KA. Imatinib disrupts lymphoma angiogenesis by targeting vascular pericytes. Blood. 121: 5192-202. PMID 23632889 DOI: 10.1182/Blood-2013-03-490763  1
2013 Sagardoy A, Martinez-Ferrandis JI, Roa S, Bunting KL, Aznar MA, Elemento O, Shaknovich R, Fontán L, Fresquet V, Perez-Roger I, Robles EF, De Smedt L, Sagaert X, Melnick A, Martinez-Climent JA. Downregulation of FOXP1 is required during germinal center B-cell function. Blood. 121: 4311-20. PMID 23580662 DOI: 10.1182/Blood-2012-10-462846  1
2013 Will B, Vogler TO, Bartholdy B, Garrett-Bakelman F, Mayer J, Barreyro L, Pandolfi A, Todorova TI, Okoye-Okafor UC, Stanley RF, Bhagat TD, Verma A, Figueroa ME, Melnick A, Roth M, et al. Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment. Nature Immunology. 14: 437-45. PMID 23563689 DOI: 10.1038/Ni.2572  1
2013 Lu Z, Tsai AG, Akasaka T, Ohno H, Jiang Y, Melnick AM, Greisman HA, Lieber MR. BCL6 breaks occur at different AID sequence motifs in Ig-BCL6 and non-Ig-BCL6 rearrangements. Blood. 121: 4551-4. PMID 23476051 DOI: 10.1182/Blood-2012-10-464958  1
2013 Huang C, Hatzi K, Melnick A. Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms Nature Immunology. 14: 380-388. PMID 23455674 DOI: 10.1038/Ni.2543  1
2013 Kannan S, Sutphin RM, Hall MG, Golfman LS, Fang W, Nolo RM, Akers LJ, Hammitt RA, McMurray JS, Kornblau SM, Melnick AM, Figueroa ME, Zweidler-McKay PA. Notch activation inhibits AML growth and survival: a potential therapeutic approach. The Journal of Experimental Medicine. 210: 321-37. PMID 23359069 DOI: 10.1084/jem.20121527  1
2013 Wilkinson AC, Ballabio E, Geng H, North P, Tapia M, Kerry J, Biswas D, Roeder RG, Allis CD, Melnick A, de Bruijn MF, Milne TA. RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction. Cell Reports. 3: 116-27. PMID 23352661 DOI: 10.1016/J.Celrep.2012.12.016  1
2013 Oh JE, Chambwe N, Klein S, Gal J, Andrews S, Gleason G, Shaknovich R, Melnick A, Campagne F, Toth M. Differential gene body methylation and reduced expression of cell adhesion and neurotransmitter receptor genes in adverse maternal environment. Translational Psychiatry. 3: e218. PMID 23340501 DOI: 10.1038/tp.2012.130  1
2013 Haggerty B, Melnick A. Translating research to policy through health impact assessment in Clark county, Washington: A commentary to accompany the active living research supplement to Annals of Behavioral Medicine Annals of Behavioral Medicine. 45: S6-S8. PMID 23334771 DOI: 10.1007/s12160-012-9450-x  1
2013 De S, Shaknovich R, Riester M, Elemento O, Geng H, Kormaksson M, Jiang Y, Woolcock B, Johnson N, Polo JM, Cerchietti L, Gascoyne RD, Melnick A, Michor F. Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity. Plos Genetics. 9: e1003137. PMID 23326238 DOI: 10.1371/Journal.Pgen.1003137  1
2013 Krivtsov AV, Figueroa ME, Sinha AU, Stubbs MC, Feng Z, Valk PJM, Delwel R, Döhner K, Bullinger L, Kung AL, Melnick AM, Armstrong SA. Cell of origin determines clinically relevant subtypes of MLL-rearranged AML Leukemia. 27: 852-860. PMID 23235717 DOI: 10.1038/Leu.2012.363  1
2013 Lin PC, Chiu YL, Banerjee S, Park K, Mosquera JM, Giannopoulou E, Alves P, Tewari AK, Gerstein MB, Beltran H, Melnick AM, Elemento O, Demichelis F, Rubin MA. Epigenetic repression of miR-31 disrupts androgen receptor homeostasis and contributes to prostate cancer progression. Cancer Research. 73: 1232-44. PMID 23233736 DOI: 10.1158/0008-5472.Can-12-2968  1
2013 Bernheim RG, Stefanak M, Brandenburg T, Pannone A, Melnick A. Public health accreditation and metrics for ethics: A case study on environmental health and community engagement Journal of Public Health Management and Practice. 19: 4-8. PMID 23169397 DOI: 10.1097/PHH.0b013e31824acb25  1
2013 Ramezani-Rad P, Geng H, Hurtz C, Chan LN, Chen Z, Jumaa H, Melnick A, Paietta E, Carroll WL, Willman CL, Lefebvre V, Müschen M. SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia. Blood. 121: 148-55. PMID 23152540 DOI: 10.1182/Blood-2012-05-428938  1
2013 Nischal S, Bhattacharyya S, Christopeit M, Yu Y, Zhou L, Bhagat TD, Sohal D, Will B, Mo Y, Suzuki M, Pardanani A, McDevitt M, Maciejewski JP, Melnick AM, Greally JM, et al. Methylome profiling reveals distinct alterations in phenotypic and mutational subgroups of myeloproliferative neoplasms. Cancer Research. 73: 1076-85. PMID 23066032 DOI: 10.1158/0008-5472.Can-12-0735  1
2013 Park-Min KH, Lee EY, Moskowitz NK, Lim E, Lee SK, Lorenzo JA, Huang C, Melnick AM, Purdue PE, Goldring SR, Ivashkiv LB. Negative regulation of osteoclast precursor differentiation by CD11b and β2 integrin-B-cell lymphoma 6 signaling. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 28: 135-49. PMID 22893614 DOI: 10.1002/Jbmr.1739  1
2013 Martin P, Elstrom RL, Ruan J, Furman RR, Garcia A, Greenberg J, Rodriguez A, Bender A, Lewis J, Melnick A, Cerchietti L, Leonard JP. Phase Ib Study Of Combination Epigenetic Therapy With 5-Azacitidine and Vorinostat In Patients With Relapsed Or Refractory DLBCL Blood. 122: 4339-4339. DOI: 10.1182/Blood.V122.21.4339.4339  1
2013 Kuo P, Perumal D, Fazzari MJ, Garrett-Bakelman FE, Saba NS, Liu D, Zhang W, Brody J, Melnick AM, Dunleavy K, Wilson WH, Wiestner A, Parekh S. High-Resolution Genomic Methylation Analysis Using Next Generation Sequencing Identifies Loci Associated With Differential Prognosis In Mantle Cell Lymphoma Patients Treated With Bortezomib + DA-EPOCH-R Blood. 122: 3760-3760. DOI: 10.1182/Blood.V122.21.3760.3760  1
2013 Loh ML, Harvey RC, Chen I, Devidas M, Davidsen TM, Auvil JMG, Gerhard DS, Smith MA, Carroll AJ, Heerema NA, Gastier-Foster JM, Willman CL, Mullighan CG, Hunger SP, Melnick A. Genome-Wide DNA Methylation Analysis Reveals Biological and Clinical Insights In Relapsed Childhood Acute Lymphoblastic Leukemia: A Report From The COG ALL Target Project Blood. 122: 3736-3736. DOI: 10.1182/Blood.V122.21.3736.3736  1
2013 Li J, Julien P, An C, Hu J, Melnick A, Mohandas N, Figueroa ME. Dynamic Changes Of DNA Methylation and a Functional Role For TET2 DNA Dioxygenase In Human Erythroid Differentiation Blood. 122: 3415-3415. DOI: 10.1182/Blood.V122.21.3415.3415  1
2013 Teater MR, Hatzi K, Popovich R, Jiang Y, Bunting KL, Rosen M, Shen H, Yang SN, Chung YR, Shaknovich R, Creasy C, Gascoyne RD, Cerchietti L, Levine RL, Abdel-Wahab O, ... Melnick AM, et al. EZH2 and BCL6 Cooperate To Create The Germinal Center B-Cell Phenotype and Induce Lymphomas Through Formation and Repression Of Bivalent Chromatin Domains Blood. 122: 1-1. DOI: 10.1182/Blood.V122.21.1.1  1
2013 Sun X, Wang Z, Wang L, Jiang Y, Soong TD, Kost N, Chen W, Elemento O, Fischle W, Melnick A, Patel DJ, Nimer SD, Roeder RG. Abstract LB-111: A stable transcription factor complex nucleated by dimeric AML1-ETO controls leukemogenesis. Molecular and Cellular Biology. DOI: 10.1158/1538-7445.Am2013-Lb-111  1
2013 Jiang Y, Redmond D, Nie K, Martin P, Melnick A, Tam W, Elemento O. Abstract 3183: Deep-sequencing reveals distinct clonal evolution patterns of DLBCL relapse and identifies mutant MLL2 as potential early driver. Cancer Research. 73: 3183-3183. DOI: 10.1158/1538-7445.Am2013-3183  1
2013 Shojaee S, Buchner M, Gery S, Geng H, Chan LN, Melnick A, Koeffler PH, Müschen M. Abstract 2334: Targeting inhibitory phosphatase signaling in Ph+ ALL. Cancer Research. 73: 2334-2334. DOI: 10.1158/1538-7445.Am2013-2334  1
2013 Goldstein RL, Cerchietti LC, Chiosis G, Melnick A. Abstract 2045: Oncoproteomic analysis of diffuse large B cell lymphomas reveals rationale for combination treatments. Cancer Research. 73: 2045-2045. DOI: 10.1158/1538-7445.Am2013-2045  1
2013 Garrett-Bakelman FE, Melnick AM. Differentiation therapy for IDH1/2 mutant malignancies Cell Research. 23: 975-977. DOI: 10.1038/cr.2013.73  1
2013 Melnick A. Two charges of intellectualism against Kant Kantian Review. 18: 197-219. DOI: 10.1017/S1369415413000010  1
2013 Rosaen CL, Carlisle JF, Mihocko E, Melnick A, Johnson J. Teachers learning from analysis of other teachers' reading lessons Teaching and Teacher Education. 35: 170-184. DOI: 10.1016/J.Tate.2013.06.007  1
2012 Fontan L, Melnick A. Targeting lymphomas through MALT1 inhibition Oncotarget. 3: 1493-1494. PMID 23455603 DOI: 10.18632/Oncotarget.819  1
2012 Polo JM, Anderssen E, Walsh RM, Schwarz BA, Nefzger CM, Lim SM, Borkent M, Apostolou E, Alaei S, Cloutier J, Bar-Nur O, Cheloufi S, Stadtfeld M, Figueroa ME, Robinton D, ... ... Melnick A, et al. A molecular roadmap of reprogramming somatic cells into iPS cells. Cell. 151: 1617-32. PMID 23260147 DOI: 10.1016/J.Cell.2012.11.039  1
2012 Fontan L, Yang C, Kabaleeswaran V, Volpon L, Osborne MJ, Beltran E, Garcia M, Cerchietti L, Shaknovich R, Yang SN, Fang F, Gascoyne RD, Martinez-Climent JA, Glickman JF, Borden K, ... ... Melnick A, et al. MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo Cancer Cell. 22: 812-824. PMID 23238016 DOI: 10.1016/J.Ccr.2012.11.003  1
2012 Alberich-Jordà M, Wouters B, Balastik M, Shapiro-Koss C, Zhang H, Di Ruscio A, DiRuscio A, Radomska HS, Ebralidze AK, Amabile G, Ye M, Zhang J, Lowers I, Avellino R, Melnick A, et al. C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia. The Journal of Clinical Investigation. 122: 4490-504. PMID 23160200 DOI: 10.1172/Jci65102  1
2012 Geng H, Brennan S, Milne TA, Chen WY, Li Y, Hurtz C, Kweon SM, Zickl L, Shojaee S, Neuberg D, Huang C, Biswas D, Xin Y, Racevskis J, Ketterling RP, ... ... Melnick AM, et al. Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia. Cancer Discovery. 2: 1004-23. PMID 23107779 DOI: 10.1158/2159-8290.Cd-12-0208  1
2012 Akalin A, Kormaksson M, Li S, Garrett-Bakelman FE, Figueroa ME, Melnick A, Mason CE. methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles. Genome Biology. 13: R87. PMID 23034086 DOI: 10.1186/Gb-2012-13-10-R87  1
2012 Busque L, Patel JP, Figueroa ME, Vasanthakumar A, Provost S, Hamilou Z, Mollica L, Li J, Viale A, Heguy A, Hassimi M, Socci N, Bhatt PK, Gonen M, Mason CE, ... Melnick A, et al. Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nature Genetics. 44: 1179-81. PMID 23001125 DOI: 10.1038/Ng.2413  1
2012 Ouillette P, Li J, Shaknovich R, Li Y, Melnick A, Shedden K, Malek SN. Incidence and clinical implications of ATM aberrations in chronic lymphocytic leukemia. Genes, Chromosomes & Cancer. 51: 1125-32. PMID 22952040 DOI: 10.1002/Gcc.21997  1
2012 Kawahara M, Pandolfi A, Bartholdy B, Barreyro L, Will B, Roth M, Okoye-Okafor UC, Todorova TI, Figueroa ME, Melnick A, Mitsiades CS, Steidl U. H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemia. Cancer Cell. 22: 194-208. PMID 22897850 DOI: 10.1016/J.Ccr.2012.06.027  1
2012 Abdel-Wahab O, Adli M, LaFave LM, Gao J, Hricik T, Shih AH, Pandey S, Patel JP, Chung YR, Koche R, Perna F, Zhao X, Taylor JE, Park CY, Carroll M, ... Melnick A, et al. ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer Cell. 22: 180-93. PMID 22897849 DOI: 10.1016/J.Ccr.2012.06.032  1
2012 Gönen M, Sun Z, Figueroa ME, Patel JP, Abdel-Wahab O, Racevskis J, Ketterling RP, Fernandez H, Rowe JM, Tallman MS, Melnick A, Levine RL, Paietta E. CD25 expression status improves prognostic risk classification in AML independent of established biomarkers: ECOG phase 3 trial, E1900. Blood. 120: 2297-306. PMID 22855599 DOI: 10.1182/Blood-2012-02-414425  1
2012 Jiang Y, Soong TD, Wang L, Melnick AM, Elemento O. Genome-wide detection of genes targeted by Non-Ig somatic hypermutation in lymphoma Plos One. 7. PMID 22808135 DOI: 10.1371/Journal.Pone.0040332  1
2012 Sasaki M, Knobbe CB, Munger JC, Lind EF, Brenner D, Brüstle A, Harris IS, Holmes R, Wakeham A, Haight J, You-Ten A, Li WY, Schalm S, Su SM, Virtanen C, ... ... Melnick A, et al. IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature. 488: 656-9. PMID 22763442 DOI: 10.1038/Nature11323  1
2012 Akalin A, Garrett-Bakelman FE, Kormaksson M, Busuttil J, Zhang L, Khrebtukova I, Milne TA, Huang Y, Biswas D, Hess JL, Allis CD, Roeder RG, Valk PJ, Löwenberg B, Delwel R, ... ... Melnick A, et al. Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. Plos Genetics. 8: e1002781. PMID 22737091 DOI: 10.1371/Journal.Pgen.1002781  1
2012 Rickman DS, Soong TD, Moss B, Mosquera JM, Dlabal J, Terry S, MacDonald TY, Tripodi J, Bunting K, Najfeld V, Demichelis F, Melnick AM, Elemento O, Rubin MA. Oncogene-mediated alterations in chromatin conformation Proceedings of the National Academy of Sciences of the United States of America. 109: 9083-9088. PMID 22615383 DOI: 10.1073/pnas.1112570109  1
2012 Melnick A. RE: Thanks, but no thanks: How denial of osteopathic service in the world wars shaped the profession Journal of the American Osteopathic Association. 112: 263-264. PMID 22582194  1
2012 Cubedo E, Gentles AJ, Huang C, Natkunam Y, Bhatt S, Lu X, Jiang X, Romero-Camarero I, Freud A, Zhao S, Bacchi CE, Martínez-Climent JA, Sánchez-García I, Melnick A, Lossos IS. Identification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma. Blood. 119: 5478-91. PMID 22517897 DOI: 10.1182/Blood-2012-01-403154  1
2012 Ribeiro AF, Pratcorona M, Erpelinck-Verschueren C, Rockova V, Sanders M, Abbas S, Figueroa ME, Zeilemaker A, Melnick A, Löwenberg B, Valk PJ, Delwel R. Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia. Blood. 119: 5824-31. PMID 22490330 DOI: 10.1182/Blood-2011-07-367961  1
2012 Barish GD, Yu RT, Karunasiri MS, Becerra D, Kim J, Tseng TW, Tai LJ, Leblanc M, Diehl C, Cerchietti L, Miller YI, Witztum JL, Melnick AM, Dent AL, Tangirala RK, et al. The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis. Cell Metabolism. 15: 554-62. PMID 22465074 DOI: 10.1016/J.Cmet.2012.02.012  1
2012 Patel JP, Gönen M, Figueroa ME, Fernandez H, Sun Z, Racevskis J, Van Vlierberghe P, Dolgalev I, Thomas S, Aminova O, Huberman K, Cheng J, Viale A, Socci ND, Heguy A, ... ... Melnick A, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. The New England Journal of Medicine. 366: 1079-89. PMID 22417203 DOI: 10.1056/Nejmoa1112304  1
2012 Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O, Edwards CR, Khanin R, Figueroa ME, Melnick A, Wellen KE, O'Rourke DM, Berger SL, Chan TA, Levine RL, et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature. 483: 474-8. PMID 22343901 DOI: 10.1038/Nature10860  1
2012 Pollyea DA, Kohrt HE, Gallegos L, Figueroa ME, Abdel-Wahab O, Zhang B, Bhattacharya S, Zehnder J, Liedtke M, Gotlib JR, Coutre S, Berube C, Melnick A, Levine R, Mitchell BS, et al. Safety, efficacy and biological predictors of response to sequential azacitidine and lenalidomide for elderly patients with acute myeloid leukemia. Leukemia. 26: 893-901. PMID 22033493 DOI: 10.1038/Leu.2011.294  1
2012 Kormaksson M, Booth JG, Figueroa ME, Melnick A. Integrative model-based clustering of microarray methylation and expression data Annals of Applied Statistics. 6: 1327-1347. DOI: 10.1214/11-Aoas533  1
2012 Pandolfi A, Bartholdy B, Kawahara M, Barreyro L, Will B, Stanley R, Michael R, Okoye-Okafor UC, Todorova TI, Figueroa ME, Melnick A, Mitsiades CS, Steidl U. H2.0-Like Homeobox (HLX) Induces Unlimited Clonogenicity, Blocks Differentiation, and Cooperates with FLT3-ITD in the Induction of Acute Myeloid Leukemia Blood. 120: 651-651. DOI: 10.1182/Blood.V120.21.651.651  1
2012 Dupont T, Dong Z, Yang S, Melnick A, Cerchietti L. Combinatorial Targeting of BCL6 and Anti-Apoptotic Proteins in Diffuse Large B-Cell Lymphoma (DLBCL) and Follicular Lymphoma (FL) Blood. 120: 64-64. DOI: 10.1182/Blood.V120.21.64.64  1
2012 Jiang Y, Hatzi K, Elemento O, Melnick A. Enhancer Profiling Reveals SOX9 As a Novel Transcription Regulator of B Cell Activation and DLBCL Transformation Blood. 120: 527-527. DOI: 10.1182/Blood.V120.21.527.527  1
2012 Elstrom RL, Cerchietti L, Martin P, Furman RR, Yang S, Ruan J, Christos P, Coleman M, Rodriguez A, Mazumdar M, Melnick A, Leonard JP. Azacitidine Priming Prior to R-CHOP Is Feasible and Results in Global Demethylation, Restoration of TGF-Beta Pathway, and Improved Chemotherapy Sensitivity in Patients with Newly Diagnosed DLBCL Blood. 120: 3706-3706. DOI: 10.1182/Blood.V120.21.3706.3706  1
2012 Bunting KL, Soong D, Jiang Y, Swed BL, Hatzi K, Shaknovich R, Reisacher W, Elemento O, Melnick A. Three-Dimensional Reorganization of the Genome During B Cell Affinity Maturation Blood. 120: 279-279. DOI: 10.1182/Blood.V120.21.279.279  1
2012 Swaminathan S, Kang H, Harvey RC, Huang C, Buchner M, Chen Z, Geng H, Hall A, Igarashi K, Carroll WL, Willman CL, Melnick A, Muschen M. BACH2 Is Required for Pre-B Cell Receptor Checkpoint Control and p53-Dependent Tumor Surveillance Blood. 120: 1300-1300. DOI: 10.1182/Blood.V120.21.1300.1300  1
2012 Rickman DS, Melnick A, Elemento O, Rubin M, Soong TD, Moss B, Mosquera JM, Dlabal J, Terry S, MacDonald T, Bunting K, Demichelis F. Abstract A31: ERG-mediated alterations in chromatin conformation Cancer Research. 72. DOI: 10.1158/1538-7445.Prca2012-A31  1
2012 Walker SR, Cerchietti LC, Nicolais MC, Yuan G, Melnick A, Frank DA. Abstract 971: Identification of BCL6 targeted therapies for breast cancer through gene expression networks Cancer Research. 72: 971-971. DOI: 10.1158/1538-7445.Am2012-971  1
2012 Rodina A, Moulick K, Ahn J, Zong H, Cerchietti L, DaGama EG, Caldas-Lopes E, Beebe K, Perna F, Hatzi K, Vu L, Zhao X, Zatorska D, Taldone T, Smith-Jones P, ... Melnick A, et al. Abstract 3029: Biochemical evidence towards the existence of an oncogenic Hsp90 complex Cancer Research. 72: 3029-3029. DOI: 10.1158/1538-7445.Am2012-3029  1
2012 Shojaee S, Buchner M, Swaminathan S, Chan L, Bothe M, Geng H, Melnick A, Molkentin J, Martin G, Koeffler P, Muschen M. Abstract 2944: Targeting negative feedback signaling in tyrosine kinase-driven malignancies Cancer Research. 72: 2944-2944. DOI: 10.1158/1538-7445.Am2012-2944  1
2012 Rickman DS, Soong TD, Moss B, Mosquera JM, Dlabal J, Terry S, MacDonald T, Bunting K, Demichelis F, Melnick A, Elemento O, Rubin MA. Abstract 2222: Oncogene-mediated alterations in chromatin conformation Molecular and Cellular Biology. DOI: 10.1158/1538-7445.Am2012-2222  1
2012 Gomes-DaGama EM, Moulick K, Ahn JH, Zong H, Rodina A, Cerchietti L, Lopes-Vazquez MEC, Beebe K, Perna F, Katerina C, Vu LP, Zhao X, Zatorska D, Taldone T, Smith-Jones P, ... Melnick AM, et al. Abstract 1263: Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90 Cancer Research. 72: 1263-1263. DOI: 10.1158/1538-7445.Am2012-1263  1
2012 Melnick A. Epigenetic Therapy Leaps Ahead with Specific Targeting of EZH2 Cancer Cell. 22: 569-570. DOI: 10.1016/j.ccr.2012.10.016  1
2012 Melnick A. Themes in Kant's metaphysics and ethics Themes in Kant's Metaphysics and Ethics. 40: 1-275.  1
2011 Pollyea DA, Kohrt HE, Gallegos L, Zhang B, Figueroa M, Melnick A, Berube C, Coutre SE, Gotlib JR, Zehnder JL, Liedtke M, Mitchell BS, Medeiros BC. Sequential azacitidine and lenalidomide in elderly acute myeloid leukemia: completed results of the phase I study. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 6505. PMID 28019999 DOI: 10.1200/Jco.2011.29.15_Suppl.6505  1
2011 Oricchio E, Nanjangud G, Wolfe AL, Schatz JH, Mavrakis KJ, Jiang M, Liu X, Bruno J, Heguy A, Olshen AB, Socci ND, Teruya-Feldstein J, Weis-Garcia F, Tam W, Shaknovich R, ... Melnick A, et al. The Eph-receptor A7 is a soluble tumor suppressor for follicular lymphoma. Cell. 147: 554-64. PMID 22036564 DOI: 10.1016/J.Cell.2011.09.035  1
2011 Cheng S, Coffey G, Zhang XH, Shaknovich R, Song Z, Lu P, Pandey A, Melnick AM, Sinha U, Wang YL. SYK inhibition and response prediction in diffuse large B-cell lymphoma Blood. 118: 6342-6352. PMID 22025527 DOI: 10.1182/blood-2011-02-333773  1
2011 Melnick A. "Whatever you are, be a good one": Osteopathic identity, equality, and the California merger Journal of the American Osteopathic Association. 111: 529-530. PMID 21955531  1
2011 Moulick K, Ahn JH, Zong H, Rodina A, Cerchietti L, Gomes DaGama EM, Caldas-Lopes E, Beebe K, Perna F, Hatzi K, Vu LP, Zhao X, Zatorska D, Taldone T, Smith-Jones P, ... ... Melnick A, et al. Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90. Nature Chemical Biology. 7: 818-26. PMID 21946277 DOI: 10.1038/Nchembio.670  1
2011 Hurtz C, Hatzi K, Cerchietti L, Braig M, Park E, Kim YM, Herzog S, Ramezani-Rad P, Jumaa H, Müller MC, Hofmann WK, Hochhaus A, Ye BH, Agarwal A, Druker BJ, ... ... Melnick AM, et al. BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia. The Journal of Experimental Medicine. 208: 2163-74. PMID 21911423 DOI: 10.1084/Jem.20110304  1
2011 Nahar R, Ramezani-Rad P, Mossner M, Duy C, Cerchietti L, Geng H, Dovat S, Jumaa H, Ye BH, Melnick A, Müschen M. Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC. Blood. 118: 4174-8. PMID 21856866 DOI: 10.1182/Blood-2011-01-331181  1
2011 Shaknovich R, Cerchietti L, Tsikitas L, Kormaksson M, De S, Figueroa ME, Ballon G, Yang SN, Weinhold N, Reimers M, Clozel T, Luttrop K, Ekstrom TJ, Frank J, Vasanthakumar A, ... ... Melnick A, et al. DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation. Blood. 118: 3559-69. PMID 21828137 DOI: 10.1182/Blood-2011-06-357996  1
2011 Wang L, Gural A, Sun XJ, Zhao X, Perna F, Huang G, Hatlen MA, Vu L, Liu F, Xu H, Asai T, Xu H, Deblasio T, Menendez S, Voza F, ... ... Melnick A, et al. The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. Science (New York, N.Y.). 333: 765-9. PMID 21764752 DOI: 10.1126/Science.1201662  1
2011 Moran-Crusio K, Reavie L, Shih A, Abdel-Wahab O, Ndiaye-Lobry D, Lobry C, Figueroa ME, Vasanthakumar A, Patel J, Zhao X, Perna F, Pandey S, Madzo J, Song C, Dai Q, ... ... Melnick A, et al. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell. 20: 11-24. PMID 21723200 DOI: 10.1016/J.Ccr.2011.06.001  1
2011 Duy C, Hurtz C, Shojaee S, Cerchietti L, Geng H, Swaminathan S, Klemm L, Kweon SM, Nahar R, Braig M, Park E, Kim YM, Hofmann WK, Herzog S, Jumaa H, ... ... Melnick A, et al. BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature. 473: 384-8. PMID 21593872 DOI: 10.1038/Nature09883  1
2011 Shaknovich R, Melnick A. Epigenetics and B-cell lymphoma Current Opinion in Hematology. 18: 293-299. PMID 21577103 DOI: 10.1097/Moh.0B013E32834788Cf  1
2011 Zhou L, Opalinska J, Sohal D, Yu Y, Mo Y, Bhagat T, Abdel-Wahab O, Fazzari M, Figueroa M, Alencar C, Zhang J, Kambhampati S, Parmar S, Nischal S, Hueck C, ... ... Melnick A, et al. Aberrant epigenetic and genetic marks are seen in myelodysplastic leukocytes and reveal Dock4 as a candidate pathogenic gene on chromosome 7q. The Journal of Biological Chemistry. 286: 25211-23. PMID 21532034 DOI: 10.1074/Jbc.M111.235028  1
2011 Cerchietti L, Damm-Welk C, Vater I, Klapper W, Harder L, Pott C, Yang SN, Reiter A, Siebert R, Melnick A, Woessmann W. Inhibition of anaplastic lymphoma kinase (ALK) activity provides a therapeutic approach for CLTC-ALK-positive human diffuse large B cell lymphomas. Plos One. 6: e18436. PMID 21494621 DOI: 10.1371/Journal.Pone.0018436  1
2011 Alvarez H, Opalinska J, Zhou L, Sohal D, Fazzari MJ, Yu Y, Montagna C, Montgomery EA, Canto M, Dunbar KB, Wang J, Roa JC, Mo Y, Bhagat T, Ramesh KH, ... ... Melnick A, et al. Widespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis. Plos Genetics. 7: e1001356. PMID 21483804 DOI: 10.1371/Journal.Pgen.1001356  1
2011 Wiesman J, Melnick A, Bright J, Carreon C, Richards K, Sherrill J, Vines J. Lessons learned from a policy decision to coordinate a multijurisdiction H1N1 response with a single incident management team. Journal of Public Health Management and Practice : Jphmp. 17: 28-35. PMID 21135658 DOI: 10.1097/PHH.0b013e3181fd4cd2  1
2011 Van Vlierberghe P, Patel J, Abdel-Wahab O, Lobry C, Hedvat CV, Balbin M, Nicolas C, Payer AR, Fernandez HF, Tallman MS, Paietta E, Melnick A, Vandenberghe P, Speleman F, Aifantis I, et al. PHF6 mutations in adult acute myeloid leukemia Leukemia. 25: 130-134. PMID 21030981 DOI: 10.1038/Leu.2010.247  1
2011 Lugthart S, Figueroa ME, Bindels E, Skrabanek L, Valk PJ, Li Y, Meyer S, Erpelinck-Verschueren C, Greally J, Löwenberg B, Melnick A, Delwel R. Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1. Blood. 117: 234-41. PMID 20855866 DOI: 10.1182/Blood-2010-04-281337  1
2011 Melnick AM, Levine RL, Figueroa ME, Thompson CB, Abdel-Wahab O. Epigenetic Effects of IDH1/IDH2 Mutations Blood. 118. DOI: 10.1182/Blood.V118.21.Sci-33.Sci-33  1
2011 Kuo P, Leshchenko VV, Gellen TA, Ulahannan N, Zumbo P, Mason CE, Wilson WH, Wiestner A, Suh KS, Goy A, Yang DT, Kahl BS, Gascoyne RD, Melnick A, Parekh S. High-Resolution Chromatin Immunoprecipitation (ChIP) Sequencing Identifies Novel Binding Targets and Prognostic Role for SOX11 in Mantle Cell Lymphoma Blood. 118: 585-585. DOI: 10.1182/Blood.V118.21.585.585  1
2011 Swaminathan S, Huang C, Titz B, Buchner M, Geng H, Graeber TG, Willman CL, Igarashi K, Melnick A, Muschen M. BACH2 Mediates Early B Cell Differentiation and Oncogene-Induced Senescence in Acute Lymphoblastic Leukemia Blood. 118: 562-562. DOI: 10.1182/Blood.V118.21.562.562  1
2011 Bunting KL, Soong TD, Chatzi K, Jiang Y, Elemento O, Melnick A. A Role for BCL6 in the Higher-Order Organization of Genes in DLBCL Blood. 118: 558-558. DOI: 10.1182/Blood.V118.21.558.558  1
2011 Hurtz C, Hatzi K, Cerchietti L, Park E, Kim Y, Ramezani-Rad P, Jumaa H, Muller MC, Hofmann W, Hochhaus A, Agarwal A, Shah N, Melnick A, Druker BJ, Muschen M. BCL6-Mediated Repression of p53 Is Critical for Leukemia Stem Cell Survival in Chronic Myeloid Leukemia Blood. 118: 446-446. DOI: 10.1182/Blood.V118.21.446.446  1
2011 Jiang Y, Soong D, Huang C, Monni S, Melnick A, Elemento O. Genomewide Detection of Genes Targeted by Aberrant Somatic Hypermutation in Lymphoma Blood. 118: 3474-3474. DOI: 10.1182/Blood.V118.21.3474.3474  1
2011 Rickman DS, Soong TD, Moss B, Kitabayashi N, Bunting K, Naseeruddin S, Garraway LA, Berger MF, Melnick A, Elemento O, Rubin MA. Abstract LB-249: Oncogene-mediated alterations in chromatin conformation Cancer Research. 71: 2222-2222. DOI: 10.1158/1538-7445.Am2011-Lb-249  1
2011 Duy C, Hurtz C, Koeffler PH, Melnick AM, Müschen M. Abstract LB-235: BCL6 enables Ph+ acute lymphoblastic leukemia cells to survive BCR-ABL1 kinase inhibition Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-235  1
2011 Rodina A, Kang Y, Taldone T, Patel H, Patel P, Caldas-Lopes E, Erdjument-Bromage H, Guzman M, Young JC, Melnick A, Chiosis G. Abstract 2579: YK5, a small molecule inhibitor of Hsp70 and Hsc70, reveals a multifaceted role for the Hsp70 chaperones in regulating oncogenic and non-oncogenic addiction of tumors Cancer Research. 71: 2579-2579. DOI: 10.1158/1538-7445.Am2011-2579  1
2011 Melnick A. Communication by degrees Journal of the American Osteopathic Association. 111: 124-125.  1
2010 Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, Li Y, Bhagwat N, Vasanthakumar A, Fernandez HF, Tallman MS, Sun Z, Wolniak K, Peeters JK, Liu W, ... ... Melnick A, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell. 18: 553-67. PMID 21130701 DOI: 10.1016/J.Ccr.2010.11.015  1
2010 Melnick AM. Epigenetics in AML Best Practice and Research: Clinical Haematology. 23: 463-468. PMID 21130408 DOI: 10.1016/j.beha.2010.09.017  1
2010 Cerchietti LC, Hatzi K, Caldas-Lopes E, Yang SN, Figueroa ME, Morin RD, Hirst M, Mendez L, Shaknovich R, Cole PA, Bhalla K, Gascoyne RD, Marra M, Chiosis G, Melnick A. BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy. The Journal of Clinical Investigation. 120: 4569-82. PMID 21041953 DOI: 10.1172/Jci42869  1
2010 Velichutina I, Shaknovich R, Geng H, Johnson NA, Gascoyne RD, Melnick AM, Elemento O. EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis. Blood. 116: 5247-55. PMID 20736451 DOI: 10.1182/blood-2010-04-280149  1
2010 Polo JM, Liu S, Figueroa ME, Kulalert W, Eminli S, Tan KY, Apostolou E, Stadtfeld M, Li Y, Shioda T, Natesan S, Wagers AJ, Melnick A, Evans T, Hochedlinger K. Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nature Biotechnology. 28: 848-55. PMID 20644536 DOI: 10.1038/Nbt.1667  1
2010 Murphy MW, Sarver AL, Rice D, Hatzi K, Ye K, Melnick A, Heckert LL, Zarkower D, Bardwell VJ. Genome-wide analysis of DNA binding and transcriptional regulation by the mammalian Doublesex homolog DMRT1 in the juvenile testis. Proceedings of the National Academy of Sciences of the United States of America. 107: 13360-5. PMID 20616082 DOI: 10.1073/Pnas.1006243107  1
2010 Shaknovich R, Geng H, Johnson NA, Tsikitas L, Cerchietti L, Greally JM, Gascoyne RD, Elemento O, Melnick A. DNA methylation signatures define molecular subtypes of diffuse large B-cell lymphoma. Blood. 116: e81-9. PMID 20610814 DOI: 10.1182/Blood-2010-05-285320  1
2010 Shah MY, Vasanthakumar A, Barnes NY, Figueroa ME, Kamp A, Hendrick C, Ostler KR, Davis EM, Lin S, Anastasi J, Le Beau MM, Moskowitz IP, Melnick A, Pytel P, Godley LA. DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis. Cancer Research. 70: 5840-50. PMID 20587527 DOI: 10.1158/0008-5472.CAN-10-0847  1
2010 Elstrom RL, Martin P, Ostrow K, Barrientos J, Chadburn A, Furman R, Ruan J, Shore T, Schuster M, Cerchietti L, Melnick A, Coleman M, Leonard JP. Response to second-line therapy defines the potential for cure in patients with recurrent diffuse large B-cell lymphoma: implications for the development of novel therapeutic strategies. Clinical Lymphoma, Myeloma & Leukemia. 10: 192-6. PMID 20511164 DOI: 10.3816/Clml.2010.N.030  1
2010 Duy C, Yu JJ, Nahar R, Swaminathan S, Kweon SM, Polo JM, Valls E, Klemm L, Shojaee S, Cerchietti L, Schuh W, Jäck HM, Hurtz C, Ramezani-Rad P, Herzog S, ... ... Melnick AM, et al. BCL6 is critical for the development of a diverse primary B cell repertoire. The Journal of Experimental Medicine. 207: 1209-21. PMID 20498019 DOI: 10.1084/Jem.20091299  1
2010 Leshchenko VV, Kuo PY, Shaknovich R, Yang DT, Gellen T, Petrich A, Yu Y, Remache Y, Weniger MA, Rafiq S, Suh KS, Goy A, Wilson W, Verma A, Braunschweig I, ... ... Melnick A, et al. Genomewide DNA methylation analysis reveals novel targets for drug development in mantle cell lymphoma. Blood. 116: 1025-34. PMID 20427703 DOI: 10.1182/Blood-2009-12-257485  1
2010 Cerchietti LC, Ghetu AF, Zhu X, Da Silva GF, Zhong S, Matthews M, Bunting KL, Polo JM, Farès C, Arrowsmith CH, Yang SN, Garcia M, Coop A, Mackerell AD, Privé GG, ... Melnick A, et al. A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo. Cancer Cell. 17: 400-11. PMID 20385364 DOI: 10.1016/J.Ccr.2009.12.050  1
2010 Winter JN, Li S, Aurora V, Variakojis D, Nelson B, Krajewska M, Zhang L, Habermann TM, Fisher RI, Macon WR, Chhanabhai M, Felgar RE, Hsi ED, Medeiros LJ, Weick JK, ... ... Melnick A, et al. Expression of p21 protein predicts clinical outcome in DLBCL patients older than 60 years treated with R-CHOP but not CHOP: a prospective ECOG and Southwest Oncology Group correlative study on E4494. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 2435-42. PMID 20371683 DOI: 10.1158/1078-0432.Ccr-09-1219  1
2010 Lubar D, White PH, Callahan LF, Chang RW, Helmick CG, Lappin DR, Melnick A, Moskowitz RW, Odom E, Sacks J, Toal SB, Waterman MB. A National Public Health Agenda for Osteoarthritis 2010. Seminars in Arthritis and Rheumatism. 39: 323-6. PMID 20307725 DOI: 10.1016/J.Semarthrit.2010.02.002  1
2010 Cairo MS, Jordan CT, Maley CC, Chao C, Melnick A, Armstrong SA, Shlomchik W, Molldrem J, Ferrone S, Mackall C, Zitvogel L, Bishop MR, Giralt SA, June CH. NCI first International Workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic stem cell transplantation: report from the committee on the biological considerations of hematological relapse following allogeneic stem cell transplantation unrelated to graft-versus-tumor effects: state of the science. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 16: 709-28. PMID 20227509 DOI: 10.1016/J.Bbmt.2010.03.002  1
2010 Kelsey JW, Slizovskiy IB, Peters RD, Melnick AM. Sterilization affects soil organic matter chemistry and bioaccumulation of spiked p,p'-DDE and anthracene by earthworms. Environmental Pollution (Barking, Essex : 1987). 158: 2251-7. PMID 20227150 DOI: 10.1016/j.envpol.2010.02.011  1
2010 Shaknovich R, Figueroa ME, Melnick A. HELP (HpaII tiny fragment enrichment by ligation-mediated PCR) assay for DNA methylation profiling of primary normal and malignant B lymphocytes. Methods in Molecular Biology (Clifton, N.J.). 632: 191-201. PMID 20217579 DOI: 10.1007/978-1-60761-663-4_12  1
2010 Schafer E, Irizarry R, Negi S, McIntyre E, Small D, Figueroa ME, Melnick A, Brown P. Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting. Blood. 115: 4798-809. PMID 20215641 DOI: 10.1182/Blood-2009-09-243634  1
2010 Figueroa ME, Lugthart S, Li Y, Erpelinck-Verschueren C, Deng X, Christos PJ, Schifano E, Booth J, van Putten W, Skrabanek L, Campagne F, Mazumdar M, Greally JM, Valk PJ, Löwenberg B, ... ... Melnick A, et al. DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia. Cancer Cell. 17: 13-27. PMID 20060365 DOI: 10.1016/J.Ccr.2009.11.020  1
2010 Hammerich-Hille S, Kaipparettu BA, Tsimelzon A, Creighton CJ, Jiang S, Polo JM, Melnick A, Meyer R, Oesterreich S. SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells. The Journal of Biological Chemistry. 285: 3608-16. PMID 19901029 DOI: 10.1074/Jbc.M109.066431  1
2010 Figueroa ME, Chen S, Andersson AK, Liu W, Cheng C, Phillips LA, Li Y, Downing JR, Melnick AM, Mullighan C. Integrated Genetic and Epigenetic Analysis of Childhood Acute Lymphoblastic Leukemia Reveals a Synergistic Role for Structural and Epigenetic Lesions In Determining Disease Phenotype Blood. 116: 537-537. DOI: 10.1182/Blood.V116.21.537.537  1
2010 Nahar R, Ramezani-Rad P, Duy C, Dovat S, Ye BH, Melnick AM, Muschen M. IKAROS and BCL6 Limit Pre-B Cell Expansion and Prevent Leukemogenesis Downstream of the Pre-B Cell Receptor Blood. 116: 146-146. DOI: 10.1182/Blood.V116.21.146.146  1
2010 Lopes EC, Bos P, Peinado H, Cerchietti L, Lavotshkin S, Melnick A, Lyden D, Chiosis G. Abstract 5766: The Hsp90 inhibitor PU-H71 is a potent suppressor of metastasis in triple-negative breast cancer models Cancer Research. 70: 5766-5766. DOI: 10.1158/1538-7445.Am10-5766  1
2010 Rodina A, Kang Y, Maharaj R, Gozman A, Taldone T, Cerchietti L, Wong MJH, Baaklini I, Caldas-Lopes E, Clement CC, Brodsky J, Erdjument-Bromage H, Ma Y, Melnick A, Young JC, et al. Abstract 5463: YK5, a novel dual Hsc70 and Hsp70 inhibitor, is selective for tumor Hsp70 and has potent but selective activity in cancer cells Cancer Research. 70: 5463-5463. DOI: 10.1158/1538-7445.Am10-5463  1
2010 Taylor KH, Shaknovich R, Martin-Subero J, Arthur G, Bennett L, Ammerpohl O, Richter J, Siebert R, Melnick A, Caldwell C. Abstract 168: Genome-wide survey of CpG methylation across the spectrum of B-cell lymphomas Cancer Research. 70: 168-168. DOI: 10.1158/1538-7445.Am10-168  1
2009 Cerchietti LC, Lopes EC, Yang SN, Hatzi K, Bunting KL, Tsikitas LA, Mallik A, Robles AI, Walling J, Varticovski L, Shaknovich R, Bhalla KN, Chiosis G, Melnick A. A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas. Nature Medicine. 15: 1369-76. PMID 19966776 DOI: 10.1038/Nm.2059  1
2009 Juszczynski P, Chen L, O'Donnell E, Polo JM, Ranuncolo SM, Dalla-Favera R, Melnick A, Shipp MA. BCL6 modulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt. Blood. 114: 5315-21. PMID 19855081 DOI: 10.1182/Blood-2009-02-204362  1
2009 Figueroa ME, Skrabanek L, Li Y, Jiemjit A, Fandy TE, Paietta E, Fernandez H, Tallman MS, Greally JM, Carraway H, Licht JD, Gore SD, Melnick A. MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation. Blood. 114: 3448-58. PMID 19652201 DOI: 10.1182/Blood-2009-01-200519  1
2009 Caldas-Lopes E, Cerchietti L, Ahn JH, Clement CC, Robles AI, Rodina A, Moulick K, Taldone T, Gozman A, Guo Y, Wu N, de Stanchina E, White J, Gross SS, Ma Y, ... ... Melnick A, et al. Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proceedings of the National Academy of Sciences of the United States of America. 106: 8368-73. PMID 19416831 DOI: 10.1073/Pnas.0903392106  1
2009 Oda M, Glass JL, Thompson RF, Mo Y, Olivier EN, Figueroa ME, Selzer RR, Richmond TA, Zhang X, Dannenberg L, Green RD, Melnick A, Hatchwell E, Bouhassira EE, Verma A, et al. High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers. Nucleic Acids Research. 37: 3829-39. PMID 19386619 DOI: 10.1093/Nar/Gkp260  1
2009 Ci W, Polo JM, Cerchietti L, Shaknovich R, Wang L, Yang SN, Ye K, Farinha P, Horsman DE, Gascoyne RD, Elemento O, Melnick A. The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL. Blood. 113: 5536-48. PMID 19307668 DOI: 10.1182/Blood-2008-12-193037  1
2009 Figueroa ME, Melnick A, Greally JM. Genome-wide determination of DNA methylation by Hpa II tiny fragment enrichment by ligation-mediated PCR (HELP) for the study of acute leukemias. Methods in Molecular Biology (Clifton, N.J.). 538: 395-407. PMID 19277580 DOI: 10.1007/978-1-59745-418-6_20  1
2009 Martin P, Chadburn A, Christos P, Weil K, Furman RR, Ruan J, Elstrom R, Niesvizky R, Ely S, Diliberto M, Melnick A, Knowles DM, Chen-Kiang S, Coleman M, Leonard JP. Outcome of deferred initial therapy in mantle-cell lymphoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: 1209-13. PMID 19188674 DOI: 10.1200/Jco.2008.19.6121  1
2009 Figueroa ME, Wouters BJ, Skrabanek L, Glass J, Li Y, Erpelinck-Verschueren CA, Langerak AW, Löwenberg B, Fazzari M, Greally JM, Valk PJ, Melnick A, Delwel R. Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features. Blood. 113: 2795-804. PMID 19168792 DOI: 10.1182/Blood-2008-08-172387  1
2009 Laurenzana A, Petruccelli LA, Pettersson F, Figueroa ME, Melnick A, Baldwin AS, Paoletti F, Miller WH. Inhibition of DNA methyltransferase activates tumor necrosis factor alpha-induced monocytic differentiation in acute myeloid leukemia cells. Cancer Research. 69: 55-64. PMID 19117987 DOI: 10.1158/0008-5472.Can-08-0245  1
2009 Cerchietti LC, Yang SN, Shaknovich R, Hatzi K, Polo JM, Chadburn A, Dowdy SF, Melnick A. A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo. Blood. 113: 3397-405. PMID 18927431 DOI: 10.1182/Blood-2008-07-168773  1
2009 Duy C, Yu JJ, Swaminathan S, Nahar RR, Kweon S, Polo JM, Valls E, Klemm L, Cerchietti L, Levetzow Gv, Herzog S, Jumaa H, Alborán IMd, Melnick A, Ye BH, et al. BCL6 Is Critical for the Development of a Diverse Primary B Cell Repertoire. Blood. 114: 91-91. DOI: 10.1182/Blood.V114.22.91.91  1
2009 Duy C, Cerchietti L, Yu JJ, Ci W, Swaminathan S, Nahar RR, Kweon S, Klemm L, Ye BH, Melnick A, Müschen M. BCL6-Dependent Negative Regulation of Cell Cycle Checkpoint Regulators Enables Drug-Resistance in Ph+ Acute Lymphoblastic Leukemia. Blood. 114: 765-765. DOI: 10.1182/Blood.V114.22.765.765  1
2009 Shaknovich R, Geng H, Johnson N, Cerchietti L, Figueroa ME, Tsikitas L, Elemento O, Connors JM, Sehn L, Gascoyne RD, Melnick A. ABC and GCB DLBCLs Display Unique Biologically Distinct and Clinically Relevant Epigenetic Signatures. Blood. 114: 619-619. DOI: 10.1182/Blood.V114.22.619.619  1
2009 Velichutina I, Shaknovich R, Geng H, Melnick A, Elemento O. EZH2 Mediates DNA Methylation-Independent Epigenetic Silencing of a Germinal Center Specific Transcriptional Program That Contributes to Cellular Proliferation and Lymphomagenesis. Blood. 114: 3465-3465. DOI: 10.1182/Blood.V114.22.3465.3465  1
2009 Hurtz C, Duy C, Cerchietti L, Park E, Ci W, Swaminathan S, Kweon S, Klemm L, Kim Y, Martinelli G, Hofmann W, Ye BH, Melnick A, Müschen M. BCL6 Is Required for Leukemia-Initiation and Self-Renewal Signaling in Chronic Myeloid Leukemia. Blood. 114: 2167-2167. DOI: 10.1182/Blood.V114.22.2167.2167  1
2009 Cerchietti LC, Ghetu A, Zhu X, Silva GD, Zhong S, Matthews M, Polo J, Farès C, Arrowsmith C, Bunting K, Coop A, MacKerell A, Privè G, Melnick A. Abstract B236: A small molecule disrupts the BCL6 transcriptional repressor complex and kills lymphoma cells in vitro and in vivo Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-B236  1
2008 Melnick A. Transitioning from fellowship to a physician-scientist career track Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 16-22. PMID 19074048 DOI: 10.1182/Asheducation-2008.1.16  1
2008 Melnick AL, Rdesinski RE, Creach ED, Choi D, Harvey SM. The Influence of Nurse Home Visits, Including Provision of 3 Months of Contraceptives and Contraceptive Counseling, on Perceived Barriers to Contraceptive Use and Contraceptive Use Self-Efficacy Women's Health Issues. 18: 471-481. PMID 18926726 DOI: 10.1016/j.whi.2008.07.011  1
2008 Lopes EC, Valls E, Figueroa ME, Mazur A, Meng FG, Chiosis G, Laird PW, Schreiber-Agus N, Greally JM, Prokhortchouk E, Melnick A. Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines. Cancer Research. 68: 7258-63. PMID 18794111 DOI: 10.1158/0008-5472.Can-08-0344  1
2008 Sohal D, Yeatts A, Ye K, Pellagatti A, Zhou L, Pahanish P, Mo Y, Bhagat T, Mariadason J, Boultwood J, Melnick A, Greally J, Verma A. Meta-analysis of microarray studies reveals a novel hematopoietic progenitor cell signature and demonstrates feasibility of inter-platform data integration. Plos One. 3: e2965. PMID 18698424 DOI: 10.1371/Journal.Pone.0002965  1
2008 Wilson AJ, Byun DS, Nasser S, Murray LB, Ayyanar K, Arango D, Figueroa M, Melnick A, Kao GD, Augenlicht LH, Mariadason JM. HDAC4 promotes growth of colon cancer cells via repression of p21. Molecular Biology of the Cell. 19: 4062-75. PMID 18632985 DOI: 10.1091/Mbc.E08-02-0139  1
2008 Ci W, Polo JM, Melnick A. B-cell lymphoma 6 and the molecular pathogenesis of diffuse large B-cell lymphoma. Current Opinion in Hematology. 15: 381-390. PMID 18536578 DOI: 10.1097/Moh.0B013E328302C7Df  1
2008 Ranuncolo SM, Wang L, Polo JM, Dell'Oso T, Dierov J, Gaymes TJ, Rassool F, Carroll M, Melnick A. BCL6-mediated attenuation of DNA damage sensing triggers growth arrest and senescence through a p53-dependent pathway in a cell context-dependent manner Journal of Biological Chemistry. 283: 22565-22572. PMID 18524763 DOI: 10.1074/Jbc.M803490200  1
2008 Polo JM, Ci W, Licht JD, Melnick A. Reversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B cells Blood. 112: 644-651. PMID 18487509 DOI: 10.1182/Blood-2008-01-131813  1
2008 Parekh S, Prive G, Melnick A. Therapeutic targeting of the BCL6 oncogene for diffuse large B-cell lymphomas Leukemia and Lymphoma. 49: 874-882. PMID 18452090 DOI: 10.1080/10428190801895345  1
2008 Cerchietti LC, Polo JM, Da Silva GF, Farinha P, Shaknovich R, Gascoyne RD, Dowdy SF, Melnick A. Sequential transcription factor targeting for diffuse large B-cell lymphomas. Cancer Research. 68: 3361-9. PMID 18451163 DOI: 10.1158/0008-5472.Can-07-5817  1
2008 Figueroa ME, Reimers M, Thompson RF, Ye K, Li Y, Selzer RR, Fridriksson J, Paietta E, Wiernik P, Green RD, Greally JM, Melnick A. An integrative genomic and epigenomic approach for the study of transcriptional regulation. Plos One. 3: e1882. PMID 18365023 DOI: 10.1371/Journal.Pone.0001882  1
2008 Ranuncolo SM, Polo JM, Melnick A. BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells. Blood Cells Molecules and Diseases. 41: 95-99. PMID 18346918 DOI: 10.1016/J.Bcmd.2008.02.003  1
2008 Ghetu AF, Corcoran CM, Cerchietti L, Bardwell VJ, Melnick A, Privé GG. Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer. Molecular Cell. 29: 384-91. PMID 18280243 DOI: 10.1016/J.Molcel.2007.12.026  1
2008 Mendez LM, Polo JM, Yu JJ, Krupski M, Ding BB, Melnick A, Ye BH. CtBP is an essential corepressor for BCL6 autoregulation. Molecular and Cellular Biology. 28: 2175-86. PMID 18212045 DOI: 10.1128/Mcb.01400-07  1
2008 Melnick A. Kant's theory of the self Kant's Theory of the Self. 1-186. DOI: 10.4324/9780203886991  1
2008 Lugthart S, Figueroa ME, Valk PJ, Li Y, Erpelinck-Verschueren C, Greally J, Löwenberg B, Melnick A, Delwel R. Two Different EVI1 Expressing Poor-Risk AML Subgroups with Distinct Epigenetic Signatures Uncovered by Genome Wide DNA Methylation Profiling Blood. 112: 757-757. DOI: 10.1182/Blood.V112.11.757.757  1
2008 Figueroa ME, Lugthart S, Li Y, Erpelinck-Verschueren C, Christos PJ, Mazumdar M, Löwenberg B, Greally J, Valk PJ, Delwel R, Melnick A. Epigenetic Signatures Identify New Clinically Relevant Subtypes and Define Gene Regulatory Patterns in Patients with Acute Myeloid Leukemia (AML) Blood. 112: 756-756. DOI: 10.1182/Blood.V112.11.756.756  1
2008 Gellen T, Kuo P, Shaknovich R, Figueroa ME, Melnick A, Wiestner A, Parekh S. Epigenetic Determinants of Pathogenesis and Resistance to Proteosome Inhibition in Mantle Cell Lymphoma. Blood. 112: 3373-3373. DOI: 10.1182/Blood.V112.11.3373.3373  1
2008 Duy C, Yu JJ, Cerchietti L, Klemm L, Nahar R, Kim Y, Heisterkamp N, Martinelli G, Hofmann W, Jumaa H, Melnick A, Ye BH, Muschen M. BCL6-Mediated Survival Signaling Promotes Drug-Resistance in BCRABL1- Driven Acute Lymphoblastic Leukemia Blood. 112: 295-295. DOI: 10.1182/Blood.V112.11.295.295  1
2007 Glass JL, Thompson RF, Khulan B, Figueroa ME, Olivier EN, Oakley EJ, Van Zant G, Bouhassira EE, Melnick A, Golden A, Fazzari MJ, Greally JM. CG dinucleotide clustering is a species-specific property of the genome. Nucleic Acids Research. 35: 6798-807. PMID 17932072 DOI: 10.1093/Nar/Gkm489  1
2007 Parekh S, Polo JM, Shaknovich R, Juszczynski P, Lev P, Ranuncolo SM, Yin Y, Klein U, Cattoretti G, Dalla Favera R, Shipp MA, Melnick A. BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms. Blood. 110: 2067-74. PMID 17545502 DOI: 10.1182/Blood-2007-01-069575  1
2007 Polo JM, Juszczynski P, Monti S, Cerchietti L, Ye K, Greally JM, Shipp M, Melnick A. Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas. Proceedings of the National Academy of Sciences of the United States of America. 104: 3207-12. PMID 17360630 DOI: 10.1073/Pnas.0611399104  1
2007 Shaknovich R, Cerchietti L, Figueroa ME, Melnick A. DNA Methyltransferase 1 Contributes to Epigenetic Signatures and Biological Phenotype during Normal B-Cell Differentiation and Lymphomagenesis. Blood. 110: 685-685. DOI: 10.1182/Blood.V110.11.685.685  1
2007 Ci W, Polo JM, Ranuncolo SM, Melnick A. A “Survival of the Fittest” Mechanism for Weeding Out Potentially Lymphomagenic B-Cells during Germinal Center B-Cell Differentiation. Blood. 110: 559-559. DOI: 10.1182/Blood.V110.11.559.559  1
2007 Polo JM, Chatzi K, Dell’Oso T, Lev P, Melnick A. BCL6 Transcriptionally Reprograms the DLBCL Genome by Forming Distinct Biochemically Active Complexes on Genes Corresponding to Different Pathways. Blood. 110: 2646-2646. DOI: 10.1182/Blood.V110.11.2646.2646  1
2007 Velichutina I, Melnick A. Regulation of Hox Genes by Polycomb Group Protein EZH2 Plays a Critical Role in Diffuse Large B-Cell Lymphoma Cells. Blood. 110: 1562-1562. DOI: 10.1182/Blood.V110.11.1562.1562  1
2006 Khulan B, Thompson RF, Ye K, Fazzari MJ, Suzuki M, Stasiek E, Figueroa ME, Glass JL, Chen Q, Montagna C, Hatchwell E, Selzer RR, Richmond TA, Green RD, Melnick A, et al. Comparative isoschizomer profiling of cytosine methylation: the HELP assay. Genome Research. 16: 1046-55. PMID 16809668 DOI: 10.1101/Gr.5273806  1
2006 Prokhortchouk A, Sansom O, Selfridge J, Caballero IM, Salozhin S, Aithozhina D, Cerchietti L, Meng FG, Augenlicht LH, Mariadason JM, Hendrich B, Melnick A, Prokhortchouk E, Clarke A, Bird A. Kaiso-deficient mice show resistance to intestinal cancer. Molecular and Cellular Biology. 26: 199-208. PMID 16354691 DOI: 10.1128/Mcb.26.1.199-208.2006  1
2006 Ryan M, Cerchietti L, Figueroa ME, Greally J, Melnick A. Sensitivity of Diffuse Large B-Cell Lymphomas to DNA Methyltransferase Inhibitors Is Associated with a Specific Epigenetic Signature. Blood. 108: 831-831. DOI: 10.1182/Blood.V108.11.831.831  1
2006 Antun A, Cerchietti L, Aparo S, Shaknovich R, Melnick A. BCL6 Inhibitor Peptide Have Powerful Anti-Lymphoma Activity in Animal Models of Diffuse Large B-Cell Lymphoma and Synergize with Other Anti-Lymphoma Drugs. Blood. 108: 827-827. DOI: 10.1182/Blood.V108.11.827.827  1
2006 Parekh S, Polo J, Juszczynski P, Lev P, Ranuncolo S, Cattoretti G, Shaknovich R, Shipp M, Melnick A. BCL6 Programs Lymphoma Cells for Survival and Differentiation through Distinct Biochemical Mechanisms, Both of Which Can Be Therapeutically Targeted. Blood. 108: 225-225. DOI: 10.1182/Blood.V108.11.225.225  1
2006 Cerchietti L, Figueroa ME, Shaknovich R, Melnick A. BCL6 Regulates Diffuse Large B-Cell Lymphoma Cell Cycle and Apoptosis Checkpoints through Direct Repression of the p300 Histone Acetyl-Transferase. Blood. 108: 1413-1413. DOI: 10.1182/Blood.V108.11.1413.1413  1
2005 Melnick AM, Adelson K, Licht JD. The theoretical basis of transcriptional therapy of cancer: can it be put into practice? Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 3957-70. PMID 15867201 DOI: 10.1200/JCO.2005.14.498  1
2004 Polo JM, Dell'Oso T, Ranuncolo SM, Cerchietti L, Beck D, Da Silva GF, Prive GG, Licht JD, Melnick A. Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells. Nature Medicine. 10: 1329-35. PMID 15531890 DOI: 10.1038/Nm1134  1
2004 Takahashi S, McConnell MJ, Harigae H, Kaku M, Sasaki T, Melnick AM, Licht JD. The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT. Blood. 103: 4650-8. PMID 14982881 DOI: 10.1182/blood-2003-08-2759  1
2004 Chevallier N, Corcoran CM, Lennon C, Hyjek E, Chadburn A, Bardwell VJ, Licht JD, Melnick A. ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein. Blood. 103: 1454-63. PMID 14551142 DOI: 10.1182/Blood-2003-06-2081  1
2004 Polo JM, Dell’Oso T, Ranuncolo SM, Cerchietti L, Silva GFD, Prive GG, Licht JD, Melnick A. Specific Peptide Disruption of the Bcl-6 Repression Complex Reveals Its Transcriptional Mechanism of Action in Normal and Malignant B-Cells and Is a Novel Therapeutic Approach for Diffuse Large B-Cell Lymphoma. Blood. 104: 5-5. DOI: 10.1182/Blood.V104.11.5.5  1
2003 Ahmad KF, Melnick A, Lax S, Bouchard D, Liu J, Kiang CL, Mayer S, Takahashi S, Licht JD, Privé GG. Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain. Molecular Cell. 12: 1551-64. PMID 14690607 DOI: 10.1016/S1097-2765(03)00454-4  1
2003 Sirulnik A, Melnick A, Zelent A, Licht JD. Molecular pathogenesis of acute promyelocytic leukaemia and APL variants. Best Practice & Research. Clinical Haematology. 16: 387-408. PMID 12935958 DOI: 10.1016/S1521-6926(03)00062-8  1
2002 Melnick A, Licht JD. Histone deacetylases as therapeutic targets in hematologic malignancies. Current Opinion in Hematology. 9: 322-32. PMID 12042707 DOI: 10.1097/00062752-200207000-00010  1
2002 Melnick A, Carlile G, Ahmad KF, Kiang CL, Corcoran C, Bardwell V, Prive GG, Licht JD. Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors. Molecular and Cellular Biology. 22: 1804-18. PMID 11865059 DOI: 10.1128/Mcb.22.6.1804-1818.2002  1
2001 Zelent A, Guidez F, Melnick A, Waxman S, Licht JD. Translocations of the RARalpha gene in acute promyelocytic leukemia. Oncogene. 20: 7186-7203. PMID 11704847 DOI: 10.1038/Sj.Onc.1204766  1
2000 Melnick A, Carlile GW, McConnell MJ, Polinger A, Hiebert SW, Licht JD. AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein. Blood. 96: 3939-47. PMID 11090081 DOI: 10.1182/Blood.V96.12.3939.H8003939_3939_3947  1
2000 Melnick A, Ahmad KF, Arai S, Polinger A, Ball H, Borden KL, Carlile GW, Prive GG, Licht JD. In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions. Molecular and Cellular Biology. 20: 6550-67. PMID 10938130 DOI: 10.1128/Mcb.20.17.6550-6567.2000  1
2000 Melnick AM, Westendorf JJ, Polinger A, Carlile GW, Arai S, Ball HJ, Lutterbach B, Hiebert SW, Licht JD. The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein Molecular and Cellular Biology. 20: 2075-2086. PMID 10688654 DOI: 10.1128/Mcb.20.6.2075-2086.2000  1
1999 Melnick A, Fruchtman S, Zelent A, Liu M, Huang Q, Boczkowska B, Calasanz MJ, Fernandez A, Licht JD, Najfeld V. Identification of novel chromosomal rearrangements in acute myelogenous leukemia involving loci on chromosome 2p23, 15q22 and 17q21 Leukemia. 13: 1534-1538. PMID 10516754 DOI: 10.1038/Sj.Leu.2401513  1
1999 Ball HJ, Melnick A, Shaknovich R, Kohanski RA, Licht JD. The promyelocytic leukemia zinc finger (PLZF) protein binds DNA in a high molecular weight complex associated with cdc2 kinase Nucleic Acids Research. 27: 4106-4113. PMID 10497277 DOI: 10.1093/Nar/27.20.4106  1
1999 Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, Owen G, Zelent A, Licht JD. A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. Blood. 94: 3737-3747. DOI: 10.1182/Blood.V94.11.3737.423K39_3737_3747  1
1999 Melnick A, Licht JD. Deconstructing a Disease: RAR, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia Blood. 93: 3167-3215. DOI: 10.1182/Blood.V93.10.3167.410K44_3167_3215  1
1998 Shaknovich R, Yeyati PL, Ivins S, Melnick A, Lempert C, Waxman S, Zelent AZ, Licht JD. The Promyelocytic Leukemia Zinc Finger Protein Affects Myeloid Cell Growth, Differentiation, and Apoptosis Molecular and Cellular Biology. 18: 5533-5545. PMID 9710637 DOI: 10.1128/Mcb.18.9.5533  1
1985 Melnick A, Allison HE. Kant's transcendental idealism : an interpretation and defense The Philosophical Review. 82: 134. DOI: 10.2307/2026408  0.01
1984 Melnick A. The Geometry of a Form of Intuition Topoi-An International Review of Philosophy. 3: 245-255. DOI: 10.1007/978-94-015-8046-5_10  0.01
1983 Melnick A. Kant on Intuition Midwest Studies in Philosophy. 8: 339-358. DOI: 10.1111/J.1475-4975.1983.Tb00474.X  0.01
1977 Melnick A, Walsh WH. Kant's Criticism of Metaphysics. The Philosophical Review. 74: 181. DOI: 10.2307/2025609  0.01
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