| Year |
Citation |
Score |
| 2023 |
Im E, Jiang Y, Stavrides PH, Darji S, Erdjument-Bromage H, Neubert TA, Choi JY, Wegiel J, Lee JH, Nixon RA. Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr-phosphorylated APP βCTF. Science Advances. 9: eadg1925. PMID 37494443 DOI: 10.1126/sciadv.adg1925 |
0.599 |
|
| 2022 |
Rao MV, Darji S, Stavrides PH, Goulbourne CN, Kumar A, Yang DS, Yoo L, Peddy J, Lee JH, Yuan A, Nixon RA. Autophagy is a novel pathway for neurofilament protein degradation . Autophagy. 1-16. PMID 36131358 DOI: 10.1080/15548627.2022.2124500 |
0.534 |
|
| 2022 |
Lee JH, Nixon RA. Autolysosomal acidification failure as a primary driver of Alzheimer disease pathogenesis. Autophagy. 1-2. PMID 35947489 DOI: 10.1080/15548627.2022.2110729 |
0.628 |
|
| 2022 |
Lee JH, Yang DS, Goulbourne CN, Im E, Stavrides P, Pensalfini A, Chan H, Bouchet-Marquis C, Bleiwas C, Berg MJ, Huo C, Peddy J, Pawlik M, Levy E, Rao M, ... ... Nixon RA, et al. Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques. Nature Neuroscience. 25: 688-701. PMID 35654956 DOI: 10.1038/s41593-022-01084-8 |
0.638 |
|
| 2022 |
Lie PPY, Yoo L, Goulbourne CN, Berg MJ, Stavrides P, Huo C, Lee JH, Nixon RA. Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca efflux and disrupted by PSEN1 loss of function. Science Advances. 8: eabj5716. PMID 35486730 DOI: 10.1126/sciadv.abj5716 |
0.56 |
|
| 2021 |
Pensalfini A, Jiang Y, Kim S, Nixon RA. Assessing Rab5 Activation in Health and Disease. Methods in Molecular Biology (Clifton, N.J.). 2293: 273-294. PMID 34453725 DOI: 10.1007/978-1-0716-1346-7_20 |
0.749 |
|
| 2021 |
Knopman DS, Amieva H, Petersen RC, Chételat G, Holtzman DM, Hyman BT, Nixon RA, Jones DT. Alzheimer disease. Nature Reviews. Disease Primers. 7: 33. PMID 33986301 DOI: 10.1038/s41572-021-00269-y |
0.335 |
|
| 2020 |
Pensalfini A, Kim S, Subbanna S, Bleiwas C, Goulbourne CN, Stavrides PH, Jiang Y, Lee JH, Darji S, Pawlik M, Huo C, Peddy J, Berg MJ, Smiley JF, Basavarajappa BS, ... Nixon RA, et al. Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease. Cell Reports. 33: 108420. PMID 33238112 DOI: 10.1016/j.celrep.2020.108420 |
0.812 |
|
| 2020 |
Nixon RA. The aging lysosome: An essential catalyst for late-onset neurodegenerative diseases. Biochimica Et Biophysica Acta. Proteins and Proteomics. 140443. PMID 32416272 DOI: 10.1016/J.Bbapap.2020.140443 |
0.359 |
|
| 2020 |
Gafson AR, Barthélemy NR, Bomont P, Carare RO, Durham HD, Julien JP, Kuhle J, Leppert D, Nixon RA, Weller RO, Zetterberg H, Matthews PM. Neurofilaments: neurobiological foundations for biomarker applications. Brain : a Journal of Neurology. PMID 32408345 DOI: 10.1093/Brain/Awaa098 |
0.312 |
|
| 2020 |
Lee JH, Wolfe DM, Darji S, McBrayer MK, Colacurcio DJ, Kumar A, Stavrides P, Mohan PS, Nixon RA. β2-adrenergic agonists rescue lysosome acidification and function in PSEN1 deficiency by reversing defective ER to lysosome delivery of ClC-7. Journal of Molecular Biology. PMID 32105735 DOI: 10.1016/J.Jmb.2020.02.021 |
0.602 |
|
| 2019 |
Bordi M, Darji S, Sato Y, Mellén M, Berg MJ, Kumar A, Jiang Y, Nixon RA. mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy. Cell Death & Disease. 10: 563. PMID 31332166 DOI: 10.1038/S41419-019-1752-5 |
0.311 |
|
| 2019 |
Ying J, Sato Y, Im E, Berg M, Bordi M, Darji S, Kumar A, Mohan PS, Bandyopadhyay U, Diaz A, Maria Cuervo A, Nixon RA. Lysosomal dysfunction in Down syndrome is APP-dependent and mediated by APP-βCTF (C99). The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31043483 DOI: 10.1523/Jneurosci.0578-19.2019 |
0.501 |
|
| 2018 |
Ju-Hyun L, Rao MV, Yang DS, Stavrides P, Im E, Pensalfini A, Huo C, Sarkar P, Yoshimori T, Nixon RA. Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo. Autophagy. PMID 30269645 DOI: 10.1080/15548627.2018.1528812 |
0.386 |
|
| 2018 |
Boland B, Yu WH, Corti O, Mollereau B, Henriques A, Bezard E, Pastores GM, Rubinsztein DC, Nixon RA, Duchen MR, Mallucci GR, Kroemer G, Levine B, Eskelinen EL, Mochel F, et al. Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing. Nature Reviews. Drug Discovery. PMID 30116051 DOI: 10.1038/Nrd.2018.109 |
0.411 |
|
| 2018 |
Lie PPY, Nixon RA. Lysosome trafficking and signaling in health and neurodegenerative diseases. Neurobiology of Disease. PMID 29859318 DOI: 10.1016/J.Nbd.2018.05.015 |
0.364 |
|
| 2017 |
Colacurcio DJ, Pensalfini A, Jiang Y, Nixon RA. Dysfunction of Autophagy and Endosomal-lysosomal Pathways: Roles in Pathogenesis of Down Syndrome and Alzheimer's Disease. Free Radical Biology & Medicine. PMID 28988799 DOI: 10.1016/J.Freeradbiomed.2017.10.001 |
0.463 |
|
| 2017 |
Nixon RA. Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 31: 2729-2743. PMID 28663518 DOI: 10.1096/Fj.201700359 |
0.49 |
|
| 2017 |
Yuan A, Rao MV, Veeranna, Nixon RA. Neurofilaments and Neurofilament Proteins in Health and Disease. Cold Spring Harbor Perspectives in Biology. 9. PMID 28373358 DOI: 10.1101/Cshperspect.A018309 |
0.318 |
|
| 2017 |
Yang DS, Stavrides P, Kumar A, Jiang Y, Mohan PS, Ohno M, Dobrenis K, Davidson CD, Saito M, Pawlik M, Huo C, Walkley SU, Nixon RA. Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and Alzheimer model mice. Human Molecular Genetics. PMID 28062666 DOI: 10.1093/Hmg/Ddx001 |
0.458 |
|
| 2016 |
Bordi M, Berg MJ, Mohan PS, Peterhoff CM, Alldred MJ, Che S, Ginsberg SD, Nixon RA. Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy. Autophagy. 1-17. PMID 27813694 DOI: 10.1080/15548627.2016.1239003 |
0.441 |
|
| 2016 |
Yuan A, Nixon RA. Specialized Roles of Neurofilament Proteins in Synapses: Relevance to Neuropsychiatric Disorders. Brain Research Bulletin. PMID 27609296 DOI: 10.1016/J.Brainresbull.2016.09.002 |
0.3 |
|
| 2016 |
Colacurcio DJ, Nixon RA. Disorders of lysosomal acidification-the emerging role of v-ATPase in aging and neurodegenerative disease. Ageing Research Reviews. PMID 27197071 DOI: 10.1016/J.Arr.2016.05.004 |
0.362 |
|
| 2016 |
Jiang Y, Rigoglioso A, Peterhoff CM, Pawlik M, Sato Y, Bleiwas C, Stavrides P, Smiley JF, Ginsberg SD, Mathews PM, Levy E, Nixon RA. Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF. Neurobiology of Aging. 39: 90-98. PMID 26923405 DOI: 10.1016/J.Neurobiolaging.2015.11.013 |
0.658 |
|
| 2016 |
Klionsky DJ, Abdelmohsen K, Abe A, Abedin J, Abeliovich H, Arozena AA, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Nixon RA, et al. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 Autophagy. 12: 443-443. PMID 26902590 DOI: 10.1080/15548627.2016.1147886 |
0.515 |
|
| 2016 |
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Nixon RA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356 |
0.546 |
|
| 2016 |
Rao MV, Campbell J, Palaniappan A, Kumar A, Nixon RA. Calpastatin inhibits motor neuron death and increases survival of hSOD1(G93A) mice. Journal of Neurochemistry. PMID 26756888 DOI: 10.1111/Jnc.13536 |
0.37 |
|
| 2015 |
Hamlett E, Boger HA, Ledreux A, Kelley CM, Mufson EJ, Falangola MF, Guilfoyle DN, Nixon RA, Patterson D, Duval N, Granholm AE. Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome. Current Alzheimer Research. PMID 26391050 DOI: 10.2174/1567205012666150921095505 |
0.39 |
|
| 2015 |
Lee JH, McBrayer MK, Wolfe DM, Haslett LJ, Kumar A, Sato Y, Lie PP, Mohan P, Coffey EE, Kompella U, Mitchell CH, Lloyd-Evans E, Nixon RA. Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification. Cell Reports. PMID 26299959 DOI: 10.1016/J.Celrep.2015.07.050 |
0.581 |
|
| 2015 |
Yuan A, Hassinger L, Rao MV, Julien JP, Miller CC, Nixon RA. Dissociation of Axonal Neurofilament Content from Its Transport Rate. Plos One. 10: e0133848. PMID 26208164 DOI: 10.1371/Journal.Pone.0133848 |
0.461 |
|
| 2015 |
Kim S, Sato Y, Mohan PS, Peterhoff C, Pensalfini A, Rigoglioso A, Jiang Y, Nixon RA. Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease. Molecular Psychiatry. PMID 26194181 DOI: 10.1038/Mp.2015.97 |
0.79 |
|
| 2015 |
Yuan A, Sershen H, Veeranna, Basavarajappa BS, Kumar A, Hashim A, Berg M, Lee JH, Sato Y, Rao MV, Mohan PS, Dyakin V, Julien JP, Lee VM, Nixon RA. Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo. Molecular Psychiatry. PMID 25869803 DOI: 10.1038/Mp.2015.45 |
0.546 |
|
| 2015 |
Hartley D, Blumenthal T, Carrillo M, DiPaolo G, Esralew L, Gardiner K, Granholm AC, Iqbal K, Krams M, Lemere C, Lott I, Mobley W, Ness S, Nixon R, Potter H, et al. Down syndrome and Alzheimer's disease: Common pathways, common goals. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 700-9. PMID 25510383 DOI: 10.1016/J.Jalz.2014.10.007 |
0.406 |
|
| 2015 |
Xu W, Fitzgerald S, Nixon RA, Levy E, Wilson DA. Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of AβPP metabolites in the Tg2576 mouse model of Alzheimer's disease. Experimental Neurology. 264: 82-91. PMID 25500142 DOI: 10.1016/J.Expneurol.2014.12.008 |
0.425 |
|
| 2015 |
Menzies FM, Garcia-Arencibia M, Imarisio S, O'Sullivan NC, Ricketts T, Kent BA, Rao MV, Lam W, Green-Thompson ZW, Nixon RA, Saksida LM, Bussey TJ, O'Kane CJ, Rubinsztein DC. Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity. Cell Death and Differentiation. 22: 433-44. PMID 25257175 DOI: 10.1038/Cdd.2014.151 |
0.393 |
|
| 2014 |
Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M, Herrup K, Kawas C, Khachaturian AS, Khachaturian ZS, ... ... Nixon RA, et al. 2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: S430-52. PMID 25341459 DOI: 10.1016/J.Jalz.2014.08.103 |
0.355 |
|
| 2014 |
Yang DS, Stavrides P, Saito M, Kumar A, Rodriguez-Navarro JA, Pawlik M, Huo C, Walkley SU, Saito M, Cuervo AM, Nixon RA. Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits. Brain : a Journal of Neurology. 137: 3300-18. PMID 25270989 DOI: 10.1093/Brain/Awu278 |
0.415 |
|
| 2014 |
Xu W, Lopez-Guzman M, Schoen C, Fitzgerald S, Lauer SL, Nixon RA, Levy E, Wilson DA. Spared piriform cortical single-unit odor processing and odor discrimination in the Tg2576 mouse model of Alzheimer's disease. Plos One. 9: e106431. PMID 25181487 DOI: 10.1371/Journal.Pone.0106431 |
0.305 |
|
| 2014 |
Xue X, Wang LR, Sato Y, Jiang Y, Berg M, Yang DS, Nixon RA, Liang XJ. Single-walled carbon nanotubes alleviate autophagic/lysosomal defects in primary glia from a mouse model of Alzheimer's disease. Nano Letters. 14: 5110-7. PMID 25115676 DOI: 10.1021/Nl501839Q |
0.437 |
|
| 2014 |
Rao MV, McBrayer MK, Campbell J, Kumar A, Hashim A, Sershen H, Stavrides PH, Ohno M, Hutton M, Nixon RA. Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 9222-34. PMID 25009256 DOI: 10.1523/Jneurosci.1132-14.2014 |
0.448 |
|
| 2014 |
Nixon RA. Alzheimer neurodegeneration, autophagy, and Abeta secretion: the ins and outs (comment on DOI 10.1002/bies.201400002). Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 36: 547. PMID 24819351 DOI: 10.1002/Bies.201400064 |
0.424 |
|
| 2014 |
Diepenbroek M, Casadei N, Esmer H, Saido TC, Takano J, Kahle PJ, Nixon RA, Rao MV, Melki R, Pieri L, Helling S, Marcus K, Krueger R, Masliah E, Riess O, et al. Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice. Human Molecular Genetics. 23: 3975-89. PMID 24619358 DOI: 10.1093/Hmg/Ddu112 |
0.364 |
|
| 2013 |
McBrayer M, Nixon RA. Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime. Biochemical Society Transactions. 41: 1495-502. PMID 24256243 DOI: 10.1042/Bst20130201 |
0.398 |
|
| 2013 |
Annunziata I, Patterson A, Helton D, Hu H, Moshiach S, Gomero E, Nixon R, D'Azzo A. Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-β secretion via deregulated lysosomal exocytosis Nature Communications. 4. PMID 24225533 DOI: 10.1038/Ncomms3734 |
0.385 |
|
| 2013 |
Yuan A, Kumar A, Sasaki T, Duff K, Nixon RA. Global axonal transport rates are unaltered in htau mice in vivo. Journal of Alzheimer's Disease : Jad. 37: 579-86. PMID 23948900 DOI: 10.3233/Jad-130671 |
0.361 |
|
| 2013 |
Nixon RA. The role of autophagy in neurodegenerative disease. Nature Medicine. 19: 983-97. PMID 23921753 DOI: 10.1038/Nm.3232 |
0.412 |
|
| 2013 |
Wolfe DM, Lee JH, Kumar A, Lee S, Orenstein SJ, Nixon RA. Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification. The European Journal of Neuroscience. 37: 1949-61. PMID 23773064 DOI: 10.1111/Ejn.12169 |
0.628 |
|
| 2013 |
Morales-Corraliza J, Schmidt SD, Mazzella MJ, Berger JD, Wilson DA, Wesson DW, Jucker M, Levy E, Nixon RA, Mathews PM. Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model. Neurobiology of Aging. 34: 137-45. PMID 22608241 DOI: 10.1016/J.Neurobiolaging.2012.04.007 |
0.637 |
|
| 2012 |
Nixon RA, Yang DS. Autophagy and neuronal cell death in neurological disorders. Cold Spring Harbor Perspectives in Biology. 4. PMID 22983160 DOI: 10.1101/Cshperspect.A008839 |
0.387 |
|
| 2012 |
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Nixon RA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496 |
0.528 |
|
| 2012 |
Ihara Y, Morishima-Kawashima M, Nixon R. The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 2. PMID 22908190 DOI: 10.1101/cshperspect.a006361 |
0.359 |
|
| 2012 |
Yuan A, Sasaki T, Kumar A, Peterhoff CM, Rao MV, Liem RK, Julien JP, Nixon RA. Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and peripheral nervous system axons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 8501-8. PMID 22723690 DOI: 10.1523/Jneurosci.1081-12.2012 |
0.36 |
|
| 2012 |
Schmidt SD, Mazzella MJ, Nixon RA, Mathews PM. Aβ measurement by enzyme-linked immunosorbent assay. Methods in Molecular Biology (Clifton, N.J.). 849: 507-27. PMID 22528112 DOI: 10.1007/978-1-61779-551-0_34 |
0.614 |
|
| 2012 |
Schmidt SD, Nixon RA, Mathews PM. Tissue processing prior to analysis of Alzheimer's disease associated proteins and metabolites, including Aβ. Methods in Molecular Biology (Clifton, N.J.). 849: 493-506. PMID 22528111 DOI: 10.1007/978-1-61779-551-0_33 |
0.582 |
|
| 2012 |
Morales-Corraliza J, Berger JD, Mazzella MJ, Veeranna, Neubert TA, Ghiso J, Rao MV, Staufenbiel M, Nixon RA, Mathews PM. Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice. Neurobiology of Aging. 33: 1125.e9-18. PMID 22206846 DOI: 10.1016/J.Neurobiolaging.2011.11.023 |
0.625 |
|
| 2012 |
Wolfe DM, Nixon RA. Autophagy failure in Alzheimer’s disease and lysosomal storage disorders: A common pathway to neurodegeneration? Autophagy of the Nervous System: Cellular Self-Digestion in Neurons and Neurological Diseases. 237-257. DOI: 10.1142/9789814350457_0010 |
0.322 |
|
| 2012 |
Morales-Corraliza J, Schmidt S, Mazzella M, Berger JD, Wilson D, Wesson D, Jucker M, Levy E, Nixon R, Mathews P. Immunization targeting a minor plaque constituent clears Aβ and rescues behavioral deficits in an Alzheimer's disease mouse model Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.1667 |
0.605 |
|
| 2011 |
Wesson DW, Borkowski AH, Landreth GE, Nixon RA, Levy E, Wilson DA. Sensory network dysfunction, behavioral impairments, and their reversibility in an Alzheimer's β-amyloidosis mouse model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 15962-71. PMID 22049439 DOI: 10.1523/Jneurosci.2085-11.2011 |
0.352 |
|
| 2011 |
Lee S, Sato Y, Nixon RA. Primary lysosomal dysfunction causes cargo-specific deficits of axonal transport leading to Alzheimer-like neuritic dystrophy. Autophagy. 7: 1562-3. PMID 22024748 DOI: 10.4161/Auto.7.12.17956 |
0.355 |
|
| 2011 |
Ginsberg SD, Mufson EJ, Alldred MJ, Counts SE, Wuu J, Nixon RA, Che S. Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. Journal of Chemical Neuroanatomy. 42: 102-10. PMID 21669283 DOI: 10.1016/J.Jchemneu.2011.05.012 |
0.435 |
|
| 2011 |
Lee S, Sato Y, Nixon RA. Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 7817-30. PMID 21613495 DOI: 10.1523/Jneurosci.6412-10.2011 |
0.398 |
|
| 2011 |
Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson DW, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, ... ... Nixon RA, et al. Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis. Autophagy. 7: 788-9. PMID 21464620 DOI: 10.4161/Auto.7.7.15596 |
0.655 |
|
| 2011 |
Wesson DW, Nixon RA, Levy E, Wilson DA. Mechanisms of neural and behavioral dysfunction in Alzheimer's disease. Molecular Neurobiology. 43: 163-79. PMID 21424679 DOI: 10.1007/S12035-011-8177-1 |
0.402 |
|
| 2011 |
Nixon RA, Yang DS. Autophagy failure in Alzheimer's disease--locating the primary defect. Neurobiology of Disease. 43: 38-45. PMID 21296668 DOI: 10.1016/J.Nbd.2011.01.021 |
0.49 |
|
| 2011 |
Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson D, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, ... ... Nixon RA, et al. Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain : a Journal of Neurology. 134: 258-77. PMID 21186265 DOI: 10.1093/Brain/Awq341 |
0.667 |
|
| 2011 |
Veeranna, Yang DS, Lee JH, Vinod KY, Stavrides P, Amin ND, Pant HC, Nixon RA. Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments. Neurobiology of Aging. 32: 2016-29. PMID 20031277 DOI: 10.1016/J.Neurobiolaging.2009.12.001 |
0.587 |
|
| 2010 |
Rubinsztein DC, Nixon RA. Rapamycin induces autophagic flux in neurons. Proceedings of the National Academy of Sciences of the United States of America. 107: E181; author reply E. PMID 21115811 DOI: 10.1073/Pnas.1014633107 |
0.375 |
|
| 2010 |
Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai LH. Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14946-54. PMID 21068297 DOI: 10.1523/Jneurosci.4305-10.2010 |
0.463 |
|
| 2010 |
Kaur G, Mohan P, Pawlik M, DeRosa S, Fajiculay J, Che S, Grubb A, Ginsberg SD, Nixon RA, Levy E. Cystatin C rescues degenerating neurons in a cystatin B-knockout mouse model of progressive myoclonus epilepsy. The American Journal of Pathology. 177: 2256-67. PMID 20889561 DOI: 10.2353/Ajpath.2010.100461 |
0.349 |
|
| 2010 |
Ginsberg SD, Mufson EJ, Counts SE, Wuu J, Alldred MJ, Nixon RA, Che S. Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 22: 631-9. PMID 20847427 DOI: 10.3233/Jad-2010-101080 |
0.43 |
|
| 2010 |
Ginsberg SD, Alldred MJ, Counts SE, Cataldo AM, Neve RL, Jiang Y, Wuu J, Chao MV, Mufson EJ, Nixon RA, Che S. Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression. Biological Psychiatry. 68: 885-93. PMID 20655510 DOI: 10.1016/J.Biopsych.2010.05.030 |
0.444 |
|
| 2010 |
Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Wolfe DM, Martinez-Vicente M, Massey AC, Sovak G, Uchiyama Y, Westaway D, Cuervo AM, Nixon RA. Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell. 141: 1146-58. PMID 20541250 DOI: 10.1016/J.Cell.2010.05.008 |
0.659 |
|
| 2010 |
Rothenberg C, Srinivasan D, Mah L, Kaushik S, Peterhoff CM, Ugolino J, Fang S, Cuervo AM, Nixon RA, Monteiro MJ. Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy. Human Molecular Genetics. 19: 3219-32. PMID 20529957 DOI: 10.1093/Hmg/Ddq231 |
0.379 |
|
| 2010 |
Wesson DW, Wilson DA, Nixon RA. Should olfactory dysfunction be used as a biomarker of Alzheimer's disease? Expert Review of Neurotherapeutics. 10: 633-5. PMID 20420483 DOI: 10.1586/Ern.10.33 |
0.375 |
|
| 2010 |
Okada H, Zhang W, Peterhoff C, Hwang JC, Nixon RA, Ryu SH, Kim TW. Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 2783-94. PMID 20354142 DOI: 10.1096/Fj.09-146357 |
0.453 |
|
| 2010 |
Tizon B, Sahoo S, Yu H, Gauthier S, Kumar AR, Mohan P, Figliola M, Pawlik M, Grubb A, Uchiyama Y, Bandyopadhyay U, Cuervo AM, Nixon RA, Levy E. Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines. Plos One. 5: e9819. PMID 20352108 DOI: 10.1371/Journal.Pone.0009819 |
0.399 |
|
| 2010 |
Jiang Y, Mullaney KA, Peterhoff CM, Che S, Schmidt SD, Boyer-Boiteau A, Ginsberg SD, Cataldo AM, Mathews PM, Nixon RA. Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proceedings of the National Academy of Sciences of the United States of America. 107: 1630-5. PMID 20080541 DOI: 10.1073/Pnas.0908953107 |
0.654 |
|
| 2010 |
Wesson DW, Levy E, Nixon RA, Wilson DA. Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 505-14. PMID 20071513 DOI: 10.1523/Jneurosci.4622-09.2010 |
0.417 |
|
| 2010 |
Lee S, Nixon RA. P1-106: Dynamic modeling of autophagy defects and their pathologic consequences in Alzheimer's disease and related diseases: Contribution of proteolysis impairment and axonal transport Alzheimer's & Dementia. 6: S205-S205. DOI: 10.1016/J.Jalz.2010.05.655 |
0.397 |
|
| 2010 |
Lee J, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Martinez-Vicente M, Massey AC, Sovak G, Uchiyama Y, Westaway D, Sisodia SS, Cuervo AM, Nixon RA. P2-271: Presenilin 1 (PS1) is required for lysosome acidification: FAD mutations of PS1 cause loss of protein turnover by autophagy Alzheimer's & Dementia. 6: S393-S394. DOI: 10.1016/J.Jalz.2010.05.1321 |
0.554 |
|
| 2009 |
Choi JH, Berger JD, Mazzella MJ, Morales-Corraliza J, Cataldo AM, Nixon RA, Ginsberg SD, Levy E, Mathews PM. Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model. Journal of Neurochemistry. 110: 1818-27. PMID 19619138 DOI: 10.1111/J.1471-4159.2009.06277.X |
0.61 |
|
| 2009 |
Mi W, Jung SS, Yu H, Schmidt SD, Nixon RA, Mathews PM, Tagliavini F, Levy E. Complexes of amyloid-beta and cystatin C in the human central nervous system. Journal of Alzheimer's Disease : Jad. 18: 273-80. PMID 19584436 DOI: 10.3233/Jad-2009-1147 |
0.643 |
|
| 2009 |
Basavarajappa BS, Nixon RA, Arancio O. Endocannabinoid system: emerging role from neurodevelopment to neurodegeneration. Mini Reviews in Medicinal Chemistry. 9: 448-62. PMID 19356123 DOI: 10.2174/138955709787847921 |
0.33 |
|
| 2009 |
Yang DS, Lee JH, Nixon RA. Monitoring autophagy in Alzheimer's disease and related neurodegenerative diseases. Methods in Enzymology. 453: 111-44. PMID 19216904 DOI: 10.1016/S0076-6879(08)04006-8 |
0.608 |
|
| 2009 |
Wilson DA, Nixon RA. Sniffing out a function for prion proteins. Nature Neuroscience. 12: 7-8. PMID 19107142 DOI: 10.1038/Nn0109-7 |
0.304 |
|
| 2009 |
Chen Y, Dyakin VV, Branch CA, Ardekani B, Yang D, Guilfoyle DN, Peterson J, Peterhoff C, Ginsberg SD, Cataldo AM, Nixon RA. In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model. Neurobiology of Aging. 30: 1453-65. PMID 18180075 DOI: 10.1016/J.Neurobiolaging.2007.11.026 |
0.355 |
|
| 2008 |
Planel E, Krishnamurthy P, Miyasaka T, Liu L, Herman M, Kumar A, Bretteville A, Figueroa HY, Yu WH, Whittington RA, Davies P, Takashima A, Nixon RA, Duff KE. Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12798-807. PMID 19036972 DOI: 10.1523/Jneurosci.4101-08.2008 |
0.367 |
|
| 2008 |
Rao MV, Mohan PS, Peterhoff CM, Yang DS, Schmidt SD, Stavrides PH, Campbell J, Chen Y, Jiang Y, Paskevich PA, Cataldo AM, Haroutunian V, Nixon RA. Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12241-54. PMID 19020018 DOI: 10.1523/Jneurosci.4119-08.2008 |
0.486 |
|
| 2008 |
Veeranna, Lee JH, Pareek TK, Jaffee H, Boland B, Vinod KY, Amin N, Kulkarni AB, Pant HC, Nixon RA. Neurofilament tail phosphorylation: identity of the RT-97 phosphoepitope and regulation in neurons by cross-talk among proline-directed kinases. Journal of Neurochemistry. 107: 35-49. PMID 18715269 DOI: 10.1111/J.1471-4159.2008.05547.X |
0.557 |
|
| 2008 |
Yang DS, Kumar A, Stavrides P, Peterson J, Peterhoff CM, Pawlik M, Levy E, Cataldo AM, Nixon RA. Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease. The American Journal of Pathology. 173: 665-81. PMID 18688038 DOI: 10.2353/Ajpath.2008.071176 |
0.427 |
|
| 2008 |
Trinchese F, Fa' M, Liu S, Zhang H, Hidalgo A, Schmidt SD, Yamaguchi H, Yoshii N, Mathews PM, Nixon RA, Arancio O. Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. The Journal of Clinical Investigation. 118: 2796-807. PMID 18596919 DOI: 10.1172/Jci34254 |
0.597 |
|
| 2008 |
Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, Nixon RA. Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6926-37. PMID 18596167 DOI: 10.1523/Jneurosci.0800-08.2008 |
0.497 |
|
| 2008 |
Cataldo AM, Mathews PM, Boiteau AB, Hassinger LC, Peterhoff CM, Jiang Y, Mullaney K, Neve RL, Gruenberg J, Nixon RA. Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects. The American Journal of Pathology. 173: 370-84. PMID 18535180 DOI: 10.2353/Ajpath.2008.071053 |
0.646 |
|
| 2008 |
Azmitia EC, Nixon R. Dystrophic serotonergic axons in neurodegenerative diseases. Brain Research. 1217: 185-94. PMID 18502405 DOI: 10.1016/J.Brainres.2008.03.060 |
0.354 |
|
| 2008 |
Nixon RA, Yang DS, Lee JH. Neurodegenerative lysosomal disorders: a continuum from development to late age. Autophagy. 4: 590-9. PMID 18497567 DOI: 10.4161/Auto.6259 |
0.623 |
|
| 2008 |
Yuan A, Kumar A, Peterhoff C, Duff K, Nixon RA. Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1682-7. PMID 18272688 DOI: 10.1523/Jneurosci.5242-07.2008 |
0.342 |
|
| 2008 |
Morales-Corraliza J, Berger JD, Mazzella MJ, Staufenbiel M, Rao MV, Nixon RA, Mathews PM. P1-079: Calpain inhibition by calpastatin overexpression reduces β-amyloid deposition in an APP transgenic mouse Alzheimer's & Dementia. 4: T229-T229. DOI: 10.1016/J.Jalz.2008.05.665 |
0.579 |
|
| 2008 |
Yang D, Stavrides P, Mohan P, Kumar A, Schmidt SD, Pawlik M, Bandyopadhyay U, Mathews PM, Levy E, Cuervo AM, Nixon RA. P1-059: Cystatin B deletion in a mouse model of Alzheimer's disease, TgCRND8, ameliorates both autophagic-lysosomal and amyloid pathologies Alzheimer's & Dementia. 4: T223-T223. DOI: 10.1016/J.Jalz.2008.05.645 |
0.627 |
|
| 2008 |
Choi JH, Diaz NS, Mazzella MJ, Ginsberg SD, Levy E, Nixon RA, Mathews PM. P1-011: Dysregulation of amyloid precursor protein levels, but not Aβ levels in Ts65Dn mouse brain Alzheimer's & Dementia. 4: T208-T209. DOI: 10.1016/J.Jalz.2008.05.596 |
0.604 |
|
| 2008 |
Kim S, Sasaki T, Nixon RA. P3-410: Alzheimer's disease-related endosome dysfunction induced by APP overexpression in neurons requires Rab5 overactivation Alzheimer's & Dementia. 4: T642-T642. DOI: 10.1016/J.Jalz.2008.05.1981 |
0.769 |
|
| 2007 |
Nixon RA. Autophagy, amyloidogenesis and Alzheimer disease. Journal of Cell Science. 120: 4081-91. PMID 18032783 DOI: 10.1242/Jcs.019265 |
0.487 |
|
| 2007 |
Mi W, Pawlik M, Sastre M, Jung SS, Radvinsky DS, Klein AM, Sommer J, Schmidt SD, Nixon RA, Mathews PM, Levy E. Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. Nature Genetics. 39: 1440-2. PMID 18026100 DOI: 10.1038/Ng.2007.29 |
0.61 |
|
| 2007 |
Battaglia F, Wang HY, Ghilardi MF, Gashi E, Quartarone A, Friedman E, Nixon RA. Cortical plasticity in Alzheimer's disease in humans and rodents. Biological Psychiatry. 62: 1405-12. PMID 17651702 DOI: 10.1016/J.Biopsych.2007.02.027 |
0.422 |
|
| 2007 |
Gandy S, Zhang YW, Ikin A, Schmidt SD, Bogush A, Levy E, Sheffield R, Nixon RA, Liao FF, Mathews PM, Xu H, Ehrlich ME. Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo. Journal of Neurochemistry. 102: 619-26. PMID 17630980 DOI: 10.1111/J.1471-4159.2007.04587.X |
0.647 |
|
| 2007 |
Falangola MF, Dyakin VV, Lee SP, Bogart A, Babb JS, Duff K, Nixon R, Helpern JA. Quantitative MRI reveals aging-associated T2 changes in mouse models of Alzheimer's disease. Nmr in Biomedicine. 20: 343-51. PMID 17451178 DOI: 10.1002/Nbm.1163 |
0.454 |
|
| 2007 |
Gandy S, Zhang YW, Ikin A, Schmidt SD, Bogush A, Levy E, Sheffield R, Nixon RA, Liao F, Mathews PM, Xu H, Ehrlich ME. Erratum: Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo (Journal of Neurochemistry (2007) 102, (619-626)) Journal of Neurochemistry. 103. DOI: 10.1111/J.1471-4159.2007.04950.X |
0.61 |
|
| 2007 |
Cataldo AM, Nixon RA. Neuronal Protein Trafficking in Alzheimer's Disease and Niemann-Pick Type C Disease Protein Trafficking in Neurons. 391-411. DOI: 10.1016/B978-012369437-9/50025-6 |
0.302 |
|
| 2006 |
Boland B, Nixon RA. Neuronal macroautophagy: from development to degeneration. Molecular Aspects of Medicine. 27: 503-19. PMID 16999991 DOI: 10.1016/J.Mam.2006.08.009 |
0.42 |
|
| 2006 |
Liang J, Yin C, Doong H, Fang S, Peterhoff C, Nixon RA, Monteiro MJ. Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation. Journal of Cell Science. 119: 4011-24. PMID 16968747 DOI: 10.1242/Jcs.03163 |
0.417 |
|
| 2006 |
Nixon RA, Cataldo AM. Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 9: 277-89. PMID 16914867 DOI: 10.3233/Jad-2006-9S331 |
0.5 |
|
| 2006 |
Butler D, Nixon RA, Bahr BA. Potential compensatory responses through autophagic/lysosomal pathways in neurodegenerative diseases. Autophagy. 2: 234-7. PMID 16874061 DOI: 10.4161/Auto.2729 |
0.381 |
|
| 2006 |
Nixon RA. Autophagy in neurodegenerative disease: friend, foe or turncoat? Trends in Neurosciences. 29: 528-35. PMID 16859759 DOI: 10.1016/J.Tins.2006.07.003 |
0.344 |
|
| 2006 |
Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, et al. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 51: 29-42. PMID 16815330 DOI: 10.1016/J.Neuron.2006.05.022 |
0.422 |
|
| 2006 |
Nixon RA. A “Protease Activation Cascade” in the Pathogenesis of Alzheimer's Disease Annals of the New York Academy of Sciences. 924: 117-131. DOI: 10.1111/J.1749-6632.2000.Tb05570.X |
0.461 |
|
| 2006 |
Jiang Y, Mullaney KA, Che S, Schmidt SD, Mathews PM, Cataldo AM, Ginsberg SD, Nixon RA. P2-061: APP expression modulates AD-related endosomal trafficking abnormalities in Down syndrome fibroblasts Alzheimer's & Dementia. 2: S250-S250. DOI: 10.1016/J.Jalz.2006.05.898 |
0.578 |
|
| 2006 |
Cataldo AM, Boyer-Boiteau A, Hassinger LC, Peterhoff CM, Jiang Y, Mathews PM, Neve RL, Nixon RA. P2-028 Alzheimer's & Dementia. 2: S240. DOI: 10.1016/J.Jalz.2006.05.865 |
0.469 |
|
| 2006 |
Choi JH, Diaz NS, Mazzella MJ, Peterson JN, Cataldo AM, Ginsberg SD, Levy E, Nixon RA, Mathews PM. P2-014: Dysregulation of brain APP in the Ts65Dn Down syndrome mouse Alzheimer's & Dementia. 2: S236-S236. DOI: 10.1016/J.Jalz.2006.05.851 |
0.535 |
|
| 2006 |
Gandy S, Zhang Y, Ikin A, Schmidt S, Sheffield R, Nixon R, Liao F, Matthews P, Xu H, Ehrlich M. S4-03-01: Evidence that aberrant post-TGN trafficking of Alzheimer's APP is sufficient to elevate brain A-beta 42 and may underlie mutant presenilin action Alzheimer's & Dementia. 2: S71-S71. DOI: 10.1016/J.Jalz.2006.05.277 |
0.398 |
|
| 2006 |
Yu WH, Lee J, Massey A, Peterhoff C, Kumar A, Mohan P, Cuervo AM, Nixon RA. O3-03-07: Presenilin-1 is required for macroautophagy: PS1 mutations causing AD confer loss of macroautophagy function Alzheimer's & Dementia. 2: S58-S58. DOI: 10.1016/J.Jalz.2006.05.211 |
0.568 |
|
| 2006 |
Lee S, Yang D, Kumar A, Levy E, Hassinger L, Cataldo AM, Nixon RA. P4-098: In vivo turnover of retrogradely transported proteins by autophagy is impaired in PS/APP transgenic mice Alzheimer's & Dementia. 2: S543-S543. DOI: 10.1016/J.Jalz.2006.05.1836 |
0.345 |
|
| 2005 |
Rubinsztein DC, DiFiglia M, Heintz N, Nixon RA, Qin ZH, Ravikumar B, Stefanis L, Tolkovsky A. Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy. 1: 11-22. PMID 16874045 DOI: 10.4161/Auto.1.1.1513 |
0.402 |
|
| 2005 |
Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH, Mohan PS, Mercken M, Farmery MR, Tjernberg LO, Jiang Y, Duff K, Uchiyama Y, Näslund J, Mathews PM, ... ... Nixon RA, et al. Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. The Journal of Cell Biology. 171: 87-98. PMID 16203860 DOI: 10.1083/Jcb.200505082 |
0.744 |
|
| 2005 |
de Grey AD, Alvarez PJ, Brady RO, Cuervo AM, Jerome WG, McCarty PL, Nixon RA, Rittmann BE, Sparrow JR. Medical bioremediation: prospects for the application of microbial catabolic diversity to aging and several major age-related diseases. Ageing Research Reviews. 4: 315-38. PMID 16040282 DOI: 10.1016/J.Arr.2005.03.008 |
0.301 |
|
| 2005 |
Schmidt SD, Nixon RA, Mathews PM. ELISA method for measurement of amyloid-beta levels. Methods in Molecular Biology (Clifton, N.J.). 299: 279-97. PMID 15980612 DOI: 10.1385/1-59259-874-9:279 |
0.625 |
|
| 2005 |
Schmidt SD, Jiang Y, Nixon RA, Mathews PM. Tissue processing prior to protein analysis and amyloid-beta quantitation. Methods in Molecular Biology (Clifton, N.J.). 299: 267-78. PMID 15980611 DOI: 10.1385/1-59259-874-9:267 |
0.584 |
|
| 2005 |
Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, et al. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. Proceedings of the National Academy of Sciences of the United States of America. 102: 8972-7. PMID 15951428 DOI: 10.1073/Pnas.0500940102 |
0.607 |
|
| 2005 |
Falangola MF, Lee SP, Nixon RA, Duff K, Helpern JA. Histological co-localization of iron in Abeta plaques of PS/APP transgenic mice. Neurochemical Research. 30: 201-5. PMID 15895823 DOI: 10.1007/S11064-004-2442-X |
0.416 |
|
| 2005 |
Falangola MF, Ardekani BA, Lee SP, Babb JS, Bogart A, Dyakin VV, Nixon R, Duff K, Helpern JA. Application of a non-linear image registration algorithm to quantitative analysis of T2 relaxation time in transgenic mouse models of AD pathology. Journal of Neuroscience Methods. 144: 91-7. PMID 15848243 DOI: 10.1016/J.Jneumeth.2004.10.012 |
0.348 |
|
| 2005 |
Nixon RA, Wegiel J, Kumar A, Yu WH, Peterhoff C, Cataldo A, Cuervo AM. Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. Journal of Neuropathology and Experimental Neurology. 64: 113-22. PMID 15751225 DOI: 10.1093/Jnen/64.2.113 |
0.49 |
|
| 2005 |
Nixon RA. Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases. Neurobiology of Aging. 26: 373-82. PMID 15639316 DOI: 10.1016/J.Neurobiolaging.2004.09.018 |
0.467 |
|
| 2004 |
Carter TL, Verdile G, Groth D, Bogush A, Thomas S, Shen P, Fraser PE, Mathews P, Nixon RA, Ehrlich ME, Kwok JB, St George-Hyslop P, Schofield P, Li Y, Yang A, et al. Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells. Alzheimer Disease and Associated Disorders. 18: 261-3. PMID 15592142 |
0.563 |
|
| 2004 |
Cataldo AM, Petanceska S, Terio NB, Peterhoff CM, Durham R, Mercken M, Mehta PD, Buxbaum J, Haroutunian V, Nixon RA. Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome. Neurobiology of Aging. 25: 1263-72. PMID 15465622 DOI: 10.1016/J.Neurobiolaging.2004.02.027 |
0.48 |
|
| 2004 |
Lee SP, Falangola MF, Nixon RA, Duff K, Helpern JA. Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 52: 538-44. PMID 15334572 DOI: 10.1002/Mrm.20196 |
0.445 |
|
| 2004 |
Veeranna, Kaji T, Boland B, Odrljin T, Mohan P, Basavarajappa BS, Peterhoff C, Cataldo A, Rudnicki A, Amin N, Li BS, Pant HC, Hungund BL, Arancio O, Nixon RA. Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease. The American Journal of Pathology. 165: 795-805. PMID 15331404 DOI: 10.1016/S0002-9440(10)63342-1 |
0.423 |
|
| 2004 |
Cataldo AM, Peterhoff CM, Schmidt SD, Terio NB, Duff K, Beard M, Mathews PM, Nixon RA. Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology. Journal of Neuropathology and Experimental Neurology. 63: 821-30. PMID 15330337 DOI: 10.1093/Jnen/63.8.821 |
0.659 |
|
| 2004 |
Yu WH, Kumar A, Peterhoff C, Shapiro Kulnane L, Uchiyama Y, Lamb BT, Cuervo AM, Nixon RA. Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease. The International Journal of Biochemistry & Cell Biology. 36: 2531-40. PMID 15325590 DOI: 10.1016/J.Biocel.2004.05.010 |
0.441 |
|
| 2004 |
Yao J, Petanceska SS, Montine TJ, Holtzman DM, Schmidt SD, Parker CA, Callahan MJ, Lipinski WJ, Bisgaier CL, Turner BA, Nixon RA, Martins RN, Ouimet C, Smith JD, Davies P, et al. Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits. Journal of Neurochemistry. 90: 1011-8. PMID 15287908 DOI: 10.1111/J.1471-4159.2004.02532.X |
0.606 |
|
| 2004 |
Sastre M, Calero M, Pawlik M, Mathews PM, Kumar A, Danilov V, Schmidt SD, Nixon RA, Frangione B, Levy E. Binding of cystatin C to Alzheimer's amyloid beta inhibits in vitro amyloid fibril formation. Neurobiology of Aging. 25: 1033-43. PMID 15212828 DOI: 10.1016/J.Neurobiolaging.2003.11.006 |
0.601 |
|
| 2004 |
Sadowski M, Pankiewicz J, Scholtzova H, Ji Y, Quartermain D, Jensen CH, Duff K, Nixon RA, Gruen RJ, Wisniewski T. Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice. Journal of Neuropathology and Experimental Neurology. 63: 418-28. PMID 15198121 DOI: 10.1093/Jnen/63.5.418 |
0.401 |
|
| 2004 |
Helpern JA, Lee SP, Falangola MF, Dyakin VV, Bogart A, Ardekani B, Duff K, Branch C, Wisniewski T, de Leon MJ, Wolf O, O'Shea J, Nixon RA. MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 51: 794-8. PMID 15065253 DOI: 10.1002/Mrm.20038 |
0.46 |
|
| 2004 |
Laudon H, Mathews PM, Karlström H, Bergman A, Farmery MR, Nixon RA, Winblad B, Gandy SE, Lendahl U, Lundkvist J, Näslund J. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein. Journal of Neurochemistry. 89: 44-53. PMID 15030388 DOI: 10.1046/J.1471-4159.2003.02298.X |
0.575 |
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| 2004 |
Nixon RA. Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up. The American Journal of Pathology. 164: 757-61. PMID 14982829 DOI: 10.1016/S0002-9440(10)63163-X |
0.5 |
|
| 2004 |
Pawlik M, Sastre M, Calero M, Mathews PM, Schmidt SD, Nixon RA, Levy E. Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid Beta Peptide. Journal of Molecular Neuroscience : Mn. 22: 13-8. PMID 14742906 DOI: 10.1385/Jmn:22:1-2:13 |
0.62 |
|
| 2004 |
Zheng P, Jiang Y, Mohan PS, Mathews PM, Nixon RA. P3-292 AD-related cathepsin D overexpression promotes mitochondrial-dependent apoptosis Neurobiology of Aging. 25: S438. DOI: 10.1016/S0197-4580(04)81442-8 |
0.55 |
|
| 2004 |
Yang D, Kumar A, Peterson J, Peterhoff CM, Duff K, Nixon RA, Jeyathevan R, Martins RN, Cataldo AM. P3-289 Neurodegeneration in a mouse model of Alzheimer's disease (AD): roles of apoptosis and autophagy Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81439-8 |
0.446 |
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| 2004 |
Pawlik M, Sastre M, Calero M, Mathews PM, Kumar A, Schmidt SD, Nixon RA, Levy E. P2-061 Binding of cystatin C to amyloid beta inhibits amyloid fibril formation Neurobiology of Aging. 25: S241. DOI: 10.1016/S0197-4580(04)80808-X |
0.568 |
|
| 2004 |
Scholtzova H, Pankiewicz J, Sadowski M, Quartermain D, Jensen CH, Duff K, Nixon RA, Helpern JH, Gruen RJ, Wisniewski T. P2-007 Age-associated behavioral, metabolic, and structural changes in wild-type littermates of Alzheimer's transgenic mice Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80755-3 |
0.325 |
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| 2004 |
Veeranna, Kaji T, Boland B, Odrljin T, Mohan P, Basavarajappa BS, Peterhoff C, Cataldo AM, Rudnicki A, Li BS, Pant HC, Hungund BL, Arancio O, Nixon RA. P1-272 Calpain mediates calcium-induced activation of the ERK 1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80585-2 |
0.395 |
|
| 2004 |
Cataldo AM, Mathews PM, Grbovic OM, Peterhoff CM, Jiang Y, Nixon RA. S5-02-03 Endosomal pathology in early stage Alzheimer's disease Neurobiology of Aging. 25: S90. DOI: 10.1016/S0197-4580(04)80305-1 |
0.579 |
|
| 2004 |
Nixon RA, Yu WH, Cuervo AM, Cataldo AM, Mathews PM, Yang D, Zheng P, Peterhoff CM, Kumar A, Jiang Y, Peterson J, Schmidt SD, Mohan P, Duff K, Hassinger L, et al. S4-03-04 Autophagy in Alzheimer's disease pathogenesis Neurobiology of Aging. 25: S70-S71. DOI: 10.1016/S0197-4580(04)80240-9 |
0.59 |
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| 2003 |
Phinney AL, Drisaldi B, Schmidt SD, Lugowski S, Coronado V, Liang Y, Horne P, Yang J, Sekoulidis J, Coomaraswamy J, Chishti MA, Cox DW, Mathews PM, Nixon RA, Carlson GA, et al. In vivo reduction of amyloid-beta by a mutant copper transporter. Proceedings of the National Academy of Sciences of the United States of America. 100: 14193-8. PMID 14617772 DOI: 10.1073/Pnas.2332851100 |
0.601 |
|
| 2003 |
Nixon RA. The calpains in aging and aging-related diseases. Ageing Research Reviews. 2: 407-18. PMID 14522243 DOI: 10.1016/S1568-1637(03)00029-1 |
0.415 |
|
| 2003 |
Battaglia F, Trinchese F, Liu S, Walter S, Nixon RA, Arancio O. Calpain inhibitors, a treatment for Alzheimer's disease: position paper. Journal of Molecular Neuroscience : Mn. 20: 357-62. PMID 14501020 DOI: 10.1385/Jmn:20:3:357 |
0.441 |
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| 2003 |
Cataldo AM, Petanceska S, Peterhoff CM, Terio NB, Epstein CJ, Villar A, Carlson EJ, Staufenbiel M, Nixon RA. App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 6788-92. PMID 12890772 DOI: 10.1523/Jneurosci.23-17-06788.2003 |
0.464 |
|
| 2003 |
Tatton W, Chen D, Chalmers-Redman R, Wheeler L, Nixon R, Tatton N. Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer's disease: anti-apoptosis by alpha-2-adrenergic receptor activation. Survey of Ophthalmology. S25-37. PMID 12852432 DOI: 10.1016/S0039-6257(03)00005-5 |
0.458 |
|
| 2003 |
Mathews PM, Nixon RA. Setback for an Alzheimer's disease vaccine: lessons learned. Neurology. 61: 7-8. PMID 12847147 DOI: 10.1212/Wnl.61.1.7 |
0.617 |
|
| 2003 |
Noble W, Olm V, Takata K, Casey E, Mary O, Meyerson J, Gaynor K, LaFrancois J, Wang L, Kondo T, Davies P, Burns M, Veeranna, Nixon R, Dickson D, et al. Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron. 38: 555-65. PMID 12765608 DOI: 10.1016/S0896-6273(03)00259-9 |
0.41 |
|
| 2003 |
Grbovic OM, Mathews PM, Jiang Y, Schmidt SD, Dinakar R, Summers-Terio NB, Ceresa BP, Nixon RA, Cataldo AM. Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production. The Journal of Biological Chemistry. 278: 31261-8. PMID 12761223 DOI: 10.1074/Jbc.M304122200 |
0.665 |
|
| 2003 |
Rao MV, Nixon RA. Defective neurofilament transport in mouse models of amyotrophic lateral sclerosis: a review. Neurochemical Research. 28: 1041-7. PMID 12737529 DOI: 10.1023/A:1023259207015 |
0.378 |
|
| 2003 |
Hasegawa H, Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, Chishti M, Horne P, Helsin D, French J, Mount HT, Nixon RA, Mercken M, Bergeron C, et al. Aβ vaccination of a genetic model of Alzheimer's disease International Congress Series. 1252: 405-409. DOI: 10.1016/S0531-5131(03)00046-3 |
0.519 |
|
| 2002 |
Rao MV, Engle LJ, Mohan PS, Yuan A, Qiu D, Cataldo A, Hassinger L, Jacobsen S, Lee VM, Andreadis A, Julien JP, Bridgman PC, Nixon RA. Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density. The Journal of Cell Biology. 159: 279-90. PMID 12403814 DOI: 10.1083/Jcb.200205062 |
0.308 |
|
| 2002 |
Rozmahel R, Mount HT, Chen F, Nguyen V, Huang J, Erdebil S, Liauw J, Yu G, Hasegawa H, Gu Y, Song YQ, Schmidt SD, Nixon RA, Mathews PM, Bergeron C, et al. Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype. Proceedings of the National Academy of Sciences of the United States of America. 99: 14452-7. PMID 12388777 DOI: 10.1073/Pnas.222413999 |
0.556 |
|
| 2002 |
Di Rosa G, Odrijin T, Nixon RA, Arancio O. Calpain inhibitors: a treatment for Alzheimer's disease. Journal of Molecular Neuroscience : Mn. 19: 135-41. PMID 12212771 DOI: 10.1007/s12031-002-0024-4 |
0.32 |
|
| 2002 |
Adamec E, Murrell JR, Takao M, Hobbs W, Nixon RA, Ghetti B, Vonsattel JP. P301L tauopathy: confocal immunofluorescence study of perinuclear aggregation of the mutated protein. Journal of the Neurological Sciences. 200: 85-93. PMID 12127682 DOI: 10.1016/S0022-510X(02)00150-8 |
0.402 |
|
| 2002 |
Mathews PM, Jiang Y, Schmidt SD, Grbovic OM, Mercken M, Nixon RA. Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments. The Journal of Biological Chemistry. 277: 36415-24. PMID 12087104 DOI: 10.1074/jbc.M205208200 |
0.537 |
|
| 2002 |
Adamec E, Mohan P, Vonsattel JP, Nixon RA. Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. Acta Neuropathologica. 104: 92-104. PMID 12070670 DOI: 10.1007/S00401-002-0528-6 |
0.449 |
|
| 2002 |
Yang DS, Tandon A, Chen F, Yu G, Yu H, Arawaka S, Hasegawa H, Duthie M, Schmidt SD, Ramabhadran TV, Nixon RA, Mathews PM, Gandy SE, Mount HT, St George-Hyslop P, et al. Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins. The Journal of Biological Chemistry. 277: 28135-42. PMID 12032140 DOI: 10.1074/Jbc.M110871200 |
0.596 |
|
| 2002 |
Mathews PM, Guerra CB, Jiang Y, Grbovic OM, Kao BH, Schmidt SD, Dinakar R, Mercken M, Hille-Rehfeld A, Rohrer J, Mehta P, Cataldo AM, Nixon RA. Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis. The Journal of Biological Chemistry. 277: 5299-307. PMID 11551970 DOI: 10.1074/Jbc.M108161200 |
0.562 |
|
| 2001 |
Nixon RA, Mathews PM, Cataldo AM. The neuronal endosomal-lysosomal system in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 3: 97-107. PMID 12214078 DOI: 10.3233/Jad-2001-3114 |
0.642 |
|
| 2001 |
Cataldo A, Rebeck GW, Ghetri B, Hulette C, Lippa C, Van Broeckhoven C, van Duijn C, Cras P, Bogdanovic N, Bird T, Peterhoff C, Nixon R. Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders. Annals of Neurology. 50: 661-5. PMID 11706973 DOI: 10.1002/Ana.1254 |
0.497 |
|
| 2001 |
Adamec E, Yang F, Cole GM, Nixon RA. Multiple-label immunocytochemistry for the evaluation of nature of cell death in experimental models of neurodegeneration. Brain Research. Brain Research Protocols. 7: 193-202. PMID 11431120 DOI: 10.1016/S1385-299X(01)00072-1 |
0.347 |
|
| 2000 |
Nixon RA. A "protease activation cascade" in the pathogenesis of Alzheimer's disease. Annals of the New York Academy of Sciences. 924: 117-31. PMID 11193788 |
0.356 |
|
| 2000 |
Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, Chishti MA, Horne P, Heslin D, French J, Mount HT, Nixon RA, Mercken M, Bergeron C, Fraser PE, et al. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature. 408: 979-82. PMID 11140685 DOI: 10.1038/35050110 |
0.597 |
|
| 2000 |
Mathews PM, Cataldo AM, Kao BH, Rudnicki AG, Qin X, Yang JL, Jiang Y, Picciano M, Hulette C, Lippa CF, Bird TD, Nochlin D, Walter J, Haass C, Lévesque L, ... ... Nixon RA, et al. Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease. Molecular Medicine (Cambridge, Mass.). 6: 878-91. PMID 11126202 DOI: 10.1007/Bf03401825 |
0.595 |
|
| 2000 |
Adamec E, Mohan PS, Cataldo AM, Vonsattel JP, Nixon RA. Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer's disease. Neuroscience. 100: 663-75. PMID 11098128 DOI: 10.1016/S0306-4522(00)00281-5 |
0.401 |
|
| 2000 |
Nixon RA, Cataldo AM, Mathews PM. The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review. Neurochemical Research. 25: 1161-72. PMID 11059790 DOI: 10.1023/A:1007675508413 |
0.648 |
|
| 2000 |
Anderson AJ, Stoltzner S, Lai F, Su J, Nixon RA. Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNEL. Neurobiology of Aging. 21: 511-24. PMID 10924764 DOI: 10.1016/S0197-4580(00)00126-3 |
0.403 |
|
| 2000 |
Cataldo AM, Peterhoff CM, Troncoso JC, Gomez-Isla T, Hyman BT, Nixon RA. Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. The American Journal of Pathology. 157: 277-86. PMID 10880397 DOI: 10.1016/S0002-9440(10)64538-5 |
0.506 |
|
| 2000 |
Mathews PM, Jiang Y, Guerra CB, Schmidt SD, Peterhoff CM, Cataldo AM, Nixon RA. Accelerated Aβ generation in AD models of lysosomal system upregulation Neurobiology of Aging. 21: 206. DOI: 10.1016/S0197-4580(00)83256-X |
0.6 |
|
| 2000 |
Bussiere T, Wicinski BA, Lin GI, Perl DP, Davies P, Nixon RA, Morrison JH, Hof PR. Stereologic analysis of vulnerable neocortical neurons in normal aging and Alzheimer's disease Neurobiology of Aging. 21: 24-25. DOI: 10.1016/S0197-4580(00)82787-6 |
0.407 |
|
| 2000 |
Nixon RA, Cataldo AM, Mathews PM, Duff K, Guerra CB, Mohan P, Jiang Y, Peterhoff C. Endosomal-lysosomal mechanisms in amyloido-genesis and neurodegeneration: Animal models Neurobiology of Aging. 21: 72. DOI: 10.1016/S0197-4580(00)82543-9 |
0.502 |
|
| 2000 |
Cataldo AM, Nixon RA, Troncoso JC, Durham RA, Buxbaum JD, Epstein C, Carlson E, Peterhoff CM. Endocytic alterations in human preclinical AD and a trisomic mouse model of down syndrome: Implications for β-amyloidogenesis Neurobiology of Aging. 21: 65. DOI: 10.1016/S0197-4580(00)82515-4 |
0.341 |
|
| 2000 |
Nixon R, Duff K, Matsuoka Y. 26. The pathobiology of tau protein in neurodegenerative diseases Biological Psychiatry. 47: S7. DOI: 10.1016/S0006-3223(00)00292-4 |
0.391 |
|
| 1999 |
Adamec E, Vonsattel JP, Nixon RA. DNA strand breaks in Alzheimer's disease. Brain Research. 849: 67-77. PMID 10592288 DOI: 10.1016/S0006-8993(99)02004-1 |
0.317 |
|
| 1999 |
Lévesque L, Annaert W, Craessaerts K, Mathews PM, Seeger M, Nixon RA, Van Leuven F, Gandy S, Westaway D, St George-Hyslop P, De Strooper B, Fraser PE. Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1. Molecular Medicine (Cambridge, Mass.). 5: 542-54. PMID 10501657 DOI: 10.1007/Bf03401981 |
0.603 |
|
| 1999 |
Lai F, Kammann E, Rebeck GW, Anderson A, Chen Y, Nixon RA. APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome. Neurology. 53: 331-6. PMID 10430422 DOI: 10.1212/Wnl.53.2.331 |
0.373 |
|
| 1999 |
Buchner K, Adamec E, Beermann ML, Nixon RA. Isoform-specific translocation of protein kinase C following glutamate administration in primary hippocampal neurons. Brain Research. Molecular Brain Research. 64: 222-35. PMID 9931492 DOI: 10.1016/S0169-328X(98)00324-6 |
0.321 |
|
| 1998 |
Nixon RA. Dynamic behavior and organization of cytoskeletal proteins in neurons: reconciling old and new findings. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 20: 798-807. PMID 9819567 DOI: 10.1002/(Sici)1521-1878(199810)20:10<798::Aid-Bies5>3.0.Co;2-7 |
0.315 |
|
| 1998 |
Troncoso JC, Cataldo AM, Nixon RA, Barnett JL, Lee MK, Checler F, Fowler DR, Smialek JE, Crain B, Martin LJ, Kawas CH. Neuropathology of preclinical and clinical late-onset Alzheimer's disease. Annals of Neurology. 43: 673-6. PMID 9585365 DOI: 10.1002/Ana.410430519 |
0.342 |
|
| 1998 |
Li J, Nixon R, Messer A, Berman S, Bursztajn S. Altered gene expression for calpain/calpastatin system in motor neuron degeneration (Mnd) mutant mouse brain and spinal cord Molecular Brain Research. 53: 174-186. PMID 9473662 DOI: 10.1016/S0169-328X(97)00295-7 |
0.306 |
|
| 1998 |
Capell A, Grünberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. The Journal of Biological Chemistry. 273: 3205-11. PMID 9452432 DOI: 10.1074/Jbc.273.6.3205 |
0.336 |
|
| 1997 |
Capell A, Saffrich R, Olivo JC, Meyn L, Walter J, Grünberg J, Mathews P, Nixon R, Dotti C, Haass C. Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation. Journal of Neurochemistry. 69: 2432-40. PMID 9375676 DOI: 10.1046/J.1471-4159.1997.69062432.X |
0.595 |
|
| 1997 |
Grynspan F, Griffin WR, Cataldo A, Katayama S, Nixon RA. Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease. Brain Research. 763: 145-58. PMID 9296555 DOI: 10.1016/S0006-8993(97)00384-3 |
0.451 |
|
| 1997 |
Cataldo AM, Barnett JL, Pieroni C, Nixon RA. Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 6142-51. PMID 9236226 DOI: 10.1523/Jneurosci.17-16-06142.1997 |
0.518 |
|
| 1997 |
Shea TB, Dahl DC, Nixon RA, Fischer I. Triton-soluble phosphovariants of the heavy neurofilament subunit in developing and mature mouse central nervous system. Journal of Neuroscience Research. 48: 515-23. PMID 9210521 DOI: 10.1002/(Sici)1097-4547(19970615)48:6<515::Aid-Jnr4>3.0.Co;2-D |
0.311 |
|
| 1997 |
Adamec E, Mercken M, Beermann ML, Didier M, Nixon RA. Acute rise in the concentration of free cytoplasmic calcium leads to dephosphorylation of the microtubule-associated protein tau. Brain Research. 757: 93-101. PMID 9200503 DOI: 10.1016/S0006-8993(97)00166-2 |
0.317 |
|
| 1997 |
Grynspan F, Griffin WB, Mohan PS, Shea TB, Nixon RA. Calpains and calpastatin in SH-SY5Y neuroblastoma cells during retinoic acid-induced differentiation and neurite outgrowth: comparison with the human brain calpain system. Journal of Neuroscience Research. 48: 181-91. PMID 9160241 DOI: 10.1002/(Sici)1097-4547(19970501)48:3<181::Aid-Jnr1>3.0.Co;2-B |
0.342 |
|
| 1996 |
Li J, Grynspan F, Berman S, Nixon R, Bursztajn S. Regional differences in gene expression for calcium activated neutral proteases (calpains) and their endogenous inhibitor calpastatin in mouse brain and spinal cord. Journal of Neurobiology. 30: 177-91. PMID 8738748 DOI: 10.1002/(Sici)1097-4695(199606)30:2<177::Aid-Neu1>3.0.Co;2-2 |
0.304 |
|
| 1996 |
Cataldo AM, Barnett JL, Mann DM, Nixon RA. Colocalization of lysosomal hydrolase and beta-amyloid in diffuse plaques of the cerebellum and striatum in Alzheimer's disease and Down's syndrome. Journal of Neuropathology and Experimental Neurology. 55: 704-15. PMID 8642396 DOI: 10.1097/00005072-199606000-00004 |
0.449 |
|
| 1996 |
Shea TB, Spencer MJ, Beermann ML, Cressman CM, Nixon RA. Calcium influx into human neuroblastoma cells induces ALZ-50 immunoreactivity: involvement of calpain-mediated hydrolysis of protein kinase C. Journal of Neurochemistry. 66: 1539-49. PMID 8627310 DOI: 10.1046/J.1471-4159.1996.66041539.X |
0.326 |
|
| 1996 |
Cataldo AM, Hamilton DJ, Barnett JL, Paskevich PA, Nixon RA. Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 186-99. PMID 8613784 DOI: 10.1523/Jneurosci.16-01-00186.1996 |
0.446 |
|
| 1996 |
Nixon R, Grynspan F, Cataldo A, Hong O, Katayama S, Mohan P, Adamec E. 573 Calpain activation, neurofibrillary pathology, and cell death in Alzheimer's disease Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80575-6 |
0.413 |
|
| 1996 |
Nixon R. 554 Frontiers of neuronal cell biology in Alzheimer disease pathogenesis Neurobiology of Aging. 17: S138. DOI: 10.1016/S0197-4580(96)80556-2 |
0.302 |
|
| 1996 |
Cataldo A, Barnett J, Nixon R. 541 Alterations in endocytosis and the localization of lysosomal hydrolases in early endosomes of neurons in Alzheimer's disease Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80543-4 |
0.432 |
|
| 1995 |
Mercken M, Fischer I, Kosik KS, Nixon RA. Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: evidence for dynamic interactions of tau with microtubules in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 8259-67. PMID 8613759 DOI: 10.1523/Jneurosci.15-12-08259.1995 |
0.339 |
|
| 1995 |
Nixon RA, Cataldo AM. The endosomal-lysosomal system of neurons: new roles. Trends in Neurosciences. 18: 489-96. PMID 8592758 DOI: 10.1016/0166-2236(95)92772-I |
0.378 |
|
| 1995 |
Shea TB, Beermann ML, Nixon RA. Aluminum treatment of intact neuroblastoma cells alters neurofilament subunit phosphorylation, solubility, and proteolysis. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 26: 1-14. PMID 8588820 DOI: 10.1007/Bf02814937 |
0.322 |
|
| 1995 |
Schwagerl AL, Mohan PS, Cataldo AM, Vonsattel JP, Kowall NW, Nixon RA. Elevated levels of the endosomal-lysosomal proteinase cathepsin D in cerebrospinal fluid in Alzheimer disease. Journal of Neurochemistry. 64: 443-6. PMID 7798944 DOI: 10.1046/J.1471-4159.1995.64010443.X |
0.409 |
|
| 1995 |
Cataldo AM, Barnett JL, Berman SA, Li J, Quarless S, Bursztajn S, Lippa C, Nixon RA. Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system. Neuron. 14: 671-80. PMID 7695914 DOI: 10.1016/0896-6273(95)90324-0 |
0.372 |
|
| 1995 |
Shea TB, Cressman CM, Spencer MJ, Beermann ML, Nixon RA. Enhancement of neurite outgrowth following calpain inhibition is mediated by protein kinase C. Journal of Neurochemistry. 65: 517-27. PMID 7616205 DOI: 10.1046/J.1471-4159.1995.65020517.X |
0.338 |
|
| 1995 |
Mercken M, Grynspan F, Nixon RA. Differential sensitivity to proteolysis by brain calpain of adult human tau, fetal human tau and PHF-tau. Febs Letters. 368: 10-4. PMID 7615058 DOI: 10.1016/0014-5793(95)00590-6 |
0.406 |
|
| 1994 |
Shea TB, Beermann ML, Honda T, Nixon RA. Secretion of amyloid precursor protein and laminin by cultured astrocytes is influenced by culture conditions. Journal of Neuroscience Research. 37: 197-207. PMID 8151728 DOI: 10.1002/Jnr.490370205 |
0.325 |
|
| 1994 |
Cataldo AM, Hamilton DJ, Nixon RA. Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease. Brain Research. 640: 68-80. PMID 8004466 DOI: 10.1016/0006-8993(94)91858-9 |
0.474 |
|
| 1994 |
Nixon RA, Cataldo AM. Free radicals, proteolysis, and the degeneration of neurons in Alzheimer disease: how essential is the beta-amyloid link? Neurobiology of Aging. 15: 463-9; discussion 47. PMID 7969724 DOI: 10.1016/0197-4580(94)90079-5 |
0.431 |
|
| 1994 |
Nixon RA, Saito KI, Grynspan F, Griffin WR, Katayama S, Honda T, Mohan PS, Shea TB, Beermann M. Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease. Annals of the New York Academy of Sciences. 747: 77-91. PMID 7847693 DOI: 10.1111/J.1749-6632.1994.Tb44402.X |
0.468 |
|
| 1994 |
Burke WJ, Galvin NJ, Chung HD, Stoff SA, Gillespie KN, Cataldo AM, Nixon RA. Degenerative changes in epinephrine tonic vasomotor neurons in Alzheimer's disease. Brain Research. 661: 35-42. PMID 7834382 DOI: 10.1016/0006-8993(94)91177-0 |
0.45 |
|
| 1994 |
Sihag RK, Wang LW, Cataldo AM, Hamlin M, Cohen CM, Nixon RA. Evidence for the association of protein 4.1 immunoreactive forms with neurofibrillary tangles in Alzheimer's disease brains. Brain Research. 656: 14-26. PMID 7804827 DOI: 10.1016/0006-8993(94)91361-7 |
0.417 |
|
| 1994 |
Nixon RA. Neuronal degenerative mechanisms as clues to pathogenesis and treatment of Alzheimer's disease. Neurobiology of Aging. 15: S61-5. PMID 7700464 DOI: 10.1016/0197-4580(94)90172-4 |
0.408 |
|
| 1994 |
Nixon RA, Paskevich PA, Sihag RK, Thayer CY. Phosphorylation on carboxyl terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: influences on regional neurofilament accumulation, interneurofilament spacing, and axon caliber. The Journal of Cell Biology. 126: 1031-46. PMID 7519617 DOI: 10.1083/Jcb.126.4.1031 |
0.308 |
|
| 1993 |
Nixon RA, Cataldo AM. The lysosomal system in neuronal cell death: a review. Annals of the New York Academy of Sciences. 679: 87-109. PMID 8512210 DOI: 10.1111/J.1749-6632.1993.Tb18291.X |
0.342 |
|
| 1993 |
Saito K, Elce JS, Hamos JE, Nixon RA. Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration. Proceedings of the National Academy of Sciences of the United States of America. 90: 2628-32. PMID 8464868 DOI: 10.1073/Pnas.90.7.2628 |
0.47 |
|
| 1993 |
Leli U, Shea TB, Cataldo A, Hauser G, Grynspan F, Beermann ML, Liepkalns VA, Nixon RA, Parker PJ. Differential expression and subcellular localization of protein kinase C alpha, beta, gamma, delta, and epsilon isoforms in SH-SY5Y neuroblastoma cells: modifications during differentiation. Journal of Neurochemistry. 60: 289-98. PMID 8417148 DOI: 10.1111/J.1471-4159.1993.Tb05850.X |
0.315 |
|
| 1993 |
Nixon RA. The regulation of neurofilament protein dynamics by phosphorylation: clues to neurofibrillary pathobiology. Brain Pathology (Zurich, Switzerland). 3: 29-38. PMID 7505700 DOI: 10.1111/J.1750-3639.1993.Tb00723.X |
0.325 |
|
| 1992 |
Shea TB, Beermann ML, Nixon RA. Sequential effects of astroglial-derived factors on neurite outgrowth: initiation by protease inhibitors and potentiation by extracellular matrix components. Journal of Neuroscience Research. 31: 309-17. PMID 1573681 DOI: 10.1002/Jnr.490310212 |
0.326 |
|
| 1992 |
Takeuchi KH, Saito KI, Nixon RA. Immunoassay and activity of calcium-activated neutral proteinase (mCANP): distribution in soluble and membrane-associated fractions in human and mouse brain. Journal of Neurochemistry. 58: 1526-32. PMID 1548485 DOI: 10.1111/J.1471-4159.1992.Tb11374.X |
0.308 |
|
| 1992 |
Leli U, Cataldo A, Shea TB, Nixon RA, Hauser G. Distinct mechanisms of differentiation of SH-SY5Y neuroblastoma cells by protein kinase C activators and inhibitors. Journal of Neurochemistry. 58: 1191-8. PMID 1548459 DOI: 10.1111/J.1471-4159.1992.Tb11328.X |
0.332 |
|
| 1992 |
Shea TB, Beermann ML, Nixon RA, Fischer I. Microtubule-associated protein tau is required for axonal neurite elaboration by neuroblastoma cells. Journal of Neuroscience Research. 32: 363-74. PMID 1433385 DOI: 10.1002/Jnr.490320308 |
0.363 |
|
| 1992 |
Shea TB, Beermann ML, Leli U, Nixon RA. Opposing influences of protein kinase activities on neurite outgrowth in human neuroblastoma cells: initiation by kinase A and restriction by kinase C. Journal of Neuroscience Research. 33: 398-407. PMID 1335089 DOI: 10.1002/Jnr.490330306 |
0.313 |
|
| 1992 |
Nixon RA, Cataldo AM, Paskevich PA, Hamilton DJ, Wheelock TR, Kanaley-Andrews L. The lysosomal system in neurons. Involvement at multiple stages of Alzheimer's disease pathogenesis. Annals of the New York Academy of Sciences. 674: 65-88. PMID 1288372 DOI: 10.1111/J.1749-6632.1992.Tb27478.X |
0.494 |
|
| 1991 |
Cataldo AM, Paskevich PA, Kominami E, Nixon RA. Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 88: 10998-1002. PMID 1837142 DOI: 10.1073/Pnas.88.24.10998 |
0.502 |
|
| 1991 |
Nixon RA, Sihag RK. Neurofilament phosphorylation: a new look at regulation and function. Trends in Neurosciences. 14: 501-6. PMID 1726767 DOI: 10.1016/0166-2236(91)90062-Y |
0.353 |
|
| 1990 |
Cataldo AM, Thayer CY, Bird ED, Wheelock TR, Nixon RA. Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin. Brain Research. 513: 181-92. PMID 2350688 DOI: 10.1016/0006-8993(90)90456-L |
0.498 |
|
| 1990 |
Nixon RA, Clarke JF, Logvinenko KB, Tan MK, Hoult M, Grynspan F. Aluminum inhibits calpain-mediated proteolysis and induces human neurofilament proteins to form protease-resistant high molecular weight complexes. Journal of Neurochemistry. 55: 1950-9. PMID 2121904 DOI: 10.1111/J.1471-4159.1990.Tb05781.X |
0.305 |
|
| 1990 |
Cataldo AM, Nixon RA. Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain. Proceedings of the National Academy of Sciences of the United States of America. 87: 3861-5. PMID 1692625 DOI: 10.1073/Pnas.87.10.3861 |
0.504 |
|
| 1989 |
Shea TB, Clarke JF, Wheelock TR, Paskevich PA, Nixon RA. Aluminum salts induce the accumulation of neurofilaments in perikarya of NB2a/dl neuroblastoma. Brain Research. 492: 53-64. PMID 2752311 DOI: 10.1016/0006-8993(89)90888-3 |
0.316 |
|
| 1989 |
Nixon RA. Calcium-activated neutral proteinases as regulators of cellular function. Implications for Alzheimer's disease pathogenesis. Annals of the New York Academy of Sciences. 568: 198-208. PMID 2560900 DOI: 10.1111/J.1749-6632.1989.Tb12509.X |
0.385 |
|
| 1988 |
Lewis SE, Nixon RA. Multiple phosphorylated variants of the high molecular mass subunit of neurofilaments in axons of retinal cell neurons: characterization and evidence for their differential association with stationary and moving neurofilaments. The Journal of Cell Biology. 107: 2689-701. PMID 3144556 DOI: 10.1083/Jcb.107.6.2689 |
0.321 |
|
| 1988 |
Shea TB, Nixon RA. Differential distribution of vimentin and neurofilament protein immunoreactivity in NB2a/d1 neuroblastoma cells following neurite retraction distinguishes two separate intermediate filament systems. Brain Research. 469: 298-302. PMID 2456847 DOI: 10.1016/0165-3806(88)90191-5 |
0.307 |
|
| 1987 |
Nixon RA, Lewis SE. Phosphorylation and dephosphorylation of neurofilament proteins in retinal ganglion cell neurons in vivo. Advances in Experimental Medicine and Biology. 221: 167-86. PMID 3124528 DOI: 10.1007/978-1-4684-7618-7_13 |
0.3 |
|
| 1987 |
Nixon RA, Lewis SE, Marotta CA. Posttranslational modification of neurofilament proteins by phosphate during axoplasmic transport in retinal ganglion cell neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 7: 1145-58. PMID 2437257 DOI: 10.1523/Jneurosci.07-04-01145.1987 |
0.309 |
|
| 1986 |
Zubenko GS, Marquis JK, Volicer L, Direnfeld LK, Langlais PJ, Nixon RA. Cerebrospinal fluid levels of angiotensin-converting enzyme, acetylcholinesterase, and dopamine metabolites in dementia associated with Alzheimer's disease and Parkinson's disease: a correlative study. Biological Psychiatry. 21: 1365-81. PMID 3024746 DOI: 10.1016/0006-3223(86)90328-8 |
0.365 |
|
| 1985 |
Zubenko GS, Volicer L, Direnfeld LK, Freeman M, Langlais PJ, Nixon RA. Cerebrospinal fluid levels of angiotensin-converting enzyme in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy. Brain Research. 328: 215-21. PMID 2985183 DOI: 10.1016/0006-8993(85)91032-7 |
0.374 |
|
| 1984 |
Pope A, Nixon RA. Proteases of human brain. Neurochemical Research. 9: 291-323. PMID 6377107 DOI: 10.1007/Bf00963980 |
0.34 |
|
| 1983 |
Nixon RA, Brown BA, Marotta CA. Limited proteolytic modification of a neurofilament protein involves a proteinase activated by endogenous levels of calcium. Brain Research. 275: 384-8. PMID 6414649 DOI: 10.1016/0006-8993(83)91003-X |
0.353 |
|
| 1982 |
Nixon RA, Brown BA, Marotta CA. Posttranslational modification of a neurofilament protein during axoplasmic transport: implications for regional specialization of CNS axons. The Journal of Cell Biology. 94: 150-8. PMID 6181078 DOI: 10.1083/Jcb.94.1.150 |
0.312 |
|
| 1980 |
Nixon RA. Protein degradation in the mouse visual system. I. Degradation of axonally transported and retinal proteins. Brain Research. 200: 69-83. PMID 6158362 DOI: 10.1016/0006-8993(80)91095-1 |
0.323 |
|
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