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Amy M. Barrios - Publications

Affiliations: 
Chemistry: Doctor of Philosophy University of Southern California, Los Angeles, CA, United States 
Area:
Inorganic Chemistry, Pharmaceutical Chemistry, Biochemistry
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42/62 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Wang H, Gaston R, Ahmed KT, Dudley GB, Barrios A. Derivatives of the Fungal Natural Product Illudalic Acid Inhibit the Activity of Protein Histidine Phosphatase PHPT1. Chemmedchem. e202300187. PMID 37267298 DOI: 10.1002/cmdc.202300187  0.369
2022 McCullough BS, Wang H, Barrios AM. Inhibitor Screen Identifies Covalent Inhibitors of the Protein Histidine Phosphatase PHPT1. Acs Medicinal Chemistry Letters. 13: 1198-1201. PMID 35859860 DOI: 10.1021/acsmedchemlett.2c00053  0.337
2020 Barrios AM. PTPs: Degrading the Undruggable. Journal of Medicinal Chemistry. PMID 32615037 DOI: 10.1021/Acs.Jmedchem.0C01000  0.414
2020 McCullough BS, Barrios AM. Fluorogenic probes for imaging cellular phosphatase activity. Current Opinion in Chemical Biology. 57: 34-40. PMID 32470893 DOI: 10.1016/J.Cbpa.2020.04.004  0.368
2020 McCullough BS, Barrios AM. In Vitro Assays for Measuring Protein Histidine Phosphatase Activity. Methods in Molecular Biology (Clifton, N.J.). 2077: 109-120. PMID 31707655 DOI: 10.1007/978-1-4939-9884-5_8  0.386
2019 McCullough BS, Batsomboon P, Hutchinson KB, Dudley GB, Barrios AM. Synthesis and PTP Inhibitory Activity of Illudalic Acid and Its Methyl Ether, with Insights into Selectivity for LAR PTP over Other Tyrosine Phosphatases under Physiologically Relevant Conditions. Journal of Natural Products. PMID 31809044 DOI: 10.1021/Acs.Jnatprod.9B00663  0.383
2019 Ma ES, Barrios AM. Rational design of a SHP-2 targeted, fluorogenic peptide substrate. Bioorganic & Medicinal Chemistry Letters. PMID 31351693 DOI: 10.1016/J.Bmcl.2019.07.034  0.326
2018 McCullough BS, Barrios AM. Facile, Fluorogenic Assay for Protein Histidine Phosphatase Activity. Biochemistry. PMID 29630837 DOI: 10.1021/Acs.Biochem.8B00278  0.302
2017 Biswas S, McCullough BS, Ma ES, LaJoie D, Russell CW, Garrett Brown D, Round JL, Ullman KS, Mulvey MA, Barrios AM. Dual colorimetric and fluorogenic probes for visualizing tyrosine phosphatase activity. Chemical Communications (Cambridge, England). PMID 28144650 DOI: 10.1039/C6Cc09204G  0.332
2015 Thorson MK, Van Wagoner RM, Harper MK, Ireland CM, Majtan T, Kraus JP, Barrios AM. Marine natural products as inhibitors of cystathionine beta-synthase activity. Bioorganic & Medicinal Chemistry Letters. 25: 1064-6. PMID 25666819 DOI: 10.1016/J.Bmcl.2015.01.013  0.354
2014 Thorson MK, Puerta DT, Cohen SM, Barrios AM. Inhibition of the lymphoid tyrosine phosphatase: the effect of zinc(II) ions and chelating ligand fragments on enzymatic activity. Bioorganic & Medicinal Chemistry Letters. 24: 4019-22. PMID 24997687 DOI: 10.1016/J.Bmcl.2014.06.016  0.445
2014 Ahmed VF, Bottini N, Barrios AM. Covalent inhibition of the lymphoid tyrosine phosphatase. Chemmedchem. 9: 296-9. PMID 24403103 DOI: 10.1002/Cmdc.201300404  0.453
2014 Sharlow ER, Leimgruber S, Murray S, Lira A, Sciotti RJ, Hickman M, Hudson T, Leed S, Caridha D, Barrios AM, Close D, Grögl M, Lazo JS. Auranofin is an apoptosis-simulating agent with in vitro and in vivo anti-leishmanial activity. Acs Chemical Biology. 9: 663-72. PMID 24328400 DOI: 10.1021/Cb400800Q  0.401
2014 Stanford SM, Krishnamurthy D, Kulkarni RA, Karver CE, Bruenger E, Walker LM, Ma CT, Chung TD, Sergienko E, Bottini N, Barrios AM. pCAP-based peptide substrates: the new tool in the box of tyrosine phosphatase assays. Methods (San Diego, Calif.). 65: 165-74. PMID 23886911 DOI: 10.1016/J.Ymeth.2013.07.022  0.35
2013 Kulkarni RA, Vellore NA, Bliss MR, Stanford SM, Falk MD, Bottini N, Baron R, Barrios AM. Substrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitors. Chembiochem : a European Journal of Chemical Biology. 14: 1640-7. PMID 23956195 DOI: 10.1002/Cbic.201300273  0.501
2013 Kulkarni RA, Stanford SM, Vellore NA, Krishnamurthy D, Bliss MR, Baron R, Bottini N, Barrios AM. Thiuram disulfides as pseudo-irreversible inhibitors of lymphoid tyrosine phosphatase. Chemmedchem. 8: 1561-8. PMID 23873737 DOI: 10.1002/Cmdc.201300215  0.425
2013 He Y, Liu S, Menon A, Stanford S, Oppong E, Gunawan AM, Wu L, Wu DJ, Barrios AM, Bottini N, Cato AC, Zhang ZY. A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases. Journal of Medicinal Chemistry. 56: 4990-5008. PMID 23713581 DOI: 10.1021/Jm400248C  0.459
2013 Thorson MK, Majtan T, Kraus JP, Barrios AM. Identification of cystathionine β-synthase inhibitors using a hydrogen sulfide selective probe. Angewandte Chemie (International Ed. in English). 52: 4641-4. PMID 23512751 DOI: 10.1002/Anie.201300841  0.364
2013 Qian Z, Liu T, Liu YY, Briesewitz R, Barrios AM, Jhiang SM, Pei D. Efficient delivery of cyclic peptides into mammalian cells with short sequence motifs. Acs Chemical Biology. 8: 423-31. PMID 23130658 DOI: 10.1021/Cb3005275  0.328
2012 Stanford SM, Panchal RG, Walker LM, Wu DJ, Falk MD, Mitra S, Damle SS, Ruble D, Kaltcheva T, Zhang S, Zhang ZY, Bavari S, Barrios AM, Bottini N. High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45. Proceedings of the National Academy of Sciences of the United States of America. 109: 13972-7. PMID 22891353 DOI: 10.1073/Pnas.1205028109  0.633
2012 Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, et al. A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nature Medicine. 18: 956-60. PMID 22610278 DOI: 10.1038/Nm.2758  0.726
2012 Obiri DD, Flink N, Maier JV, Neeb A, Maddalo D, Thiele W, Menon A, Stassen M, Kulkarni RA, Garabedian MJ, Barrios AM, Cato ACB. PEST-domain-enriched tyrosine phosphatase and glucocorticoids as regulators of anaphylaxis in mice Allergy: European Journal of Allergy and Clinical Immunology. 67: 175-182. PMID 21981059 DOI: 10.1111/J.1398-9995.2011.02731.X  0.307
2011 Stanford SM, Krishnamurthy D, Falk MD, Messina R, Debnath B, Li S, Liu T, Kazemi R, Dahl R, He Y, Yu X, Chan AC, Zhang ZY, Barrios AM, Woods VL, et al. Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. Journal of Medicinal Chemistry. 54: 1640-54. PMID 21341673 DOI: 10.1021/Jm101202J  0.456
2011 Karver CE, Ahmed VF, Barrios AM. Oxidative inactivation of the lymphoid tyrosine phosphatase mediated by both general and active site directed NO donors. Bioorganic & Medicinal Chemistry Letters. 21: 285-7. PMID 21129966 DOI: 10.1016/J.Bmcl.2010.11.025  0.335
2010 Karver MR, Krishnamurthy D, Bottini N, Barrios AM. Gold(I) phosphine mediated selective inhibition of lymphoid tyrosine phosphatase. Journal of Inorganic Biochemistry. 104: 268-73. PMID 20083307 DOI: 10.1016/J.Jinorgbio.2009.12.012  0.76
2009 Karver MR, Krishnamurthy D, Kulkarni RA, Bottini N, Barrios AM. Identifying potent, selective protein tyrosine phosphatase inhibitors from a library of Au(I) complexes. Journal of Medicinal Chemistry. 52: 6912-8. PMID 19888762 DOI: 10.1021/Jm901220M  0.77
2009 Krishnamurthy D, Barrios AM. Profiling protein tyrosine phosphatase activity with mechanistic probes. Current Opinion in Chemical Biology. 13: 375-81. PMID 19716756 DOI: 10.1016/J.Cbpa.2009.07.017  0.34
2008 Karver MR, Barrios AM. Identifying and characterizing the biological targets of metallotherapeutics: Two approaches using Au(I)-protein interactions as model systems. Analytical Biochemistry. 382: 63-5. PMID 18692018 DOI: 10.1016/J.Ab.2008.07.019  0.742
2008 Krishnamurthy D, Karver MR, Fiorillo E, Orrú V, Stanford SM, Bottini N, Barrios AM. Gold(I)-mediated inhibition of protein tyrosine phosphatases: a detailed in vitro and cellular study. Journal of Medicinal Chemistry. 51: 4790-5. PMID 18605719 DOI: 10.1021/Jm800101W  0.773
2008 Franzman MA, Barrios AM. Spectroscopic evidence for the formation of goldfingers. Inorganic Chemistry. 47: 3928-30. PMID 18426199 DOI: 10.1021/Ic800157T  0.362
2008 Mitra S, Barrios AM. Identifying selective protein tyrosine phosphatase substrates and inhibitors from a fluorogenic, combinatorial peptide library. Chembiochem : a European Journal of Chemical Biology. 9: 1216-9. PMID 18412190 DOI: 10.1002/Cbic.200800046  0.612
2008 Gunatilleke SS, de Oliveira CA, McCammon JA, Barrios AM. Inhibition of cathepsin B by Au(I) complexes: a kinetic and computational study. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 13: 555-61. PMID 18253767 DOI: 10.1007/S00775-008-0344-0  0.773
2008 Hubbard CE, Barrios AM. A highly efficient route to enantiomerically pure l-N-Bz-Pmp(t-Bu)2-OH and incorporation into a peptide-based protein tyrosine phosphatase inhibitor. Bioorganic & Medicinal Chemistry Letters. 18: 679-81. PMID 18240386 DOI: 10.1016/J.Bmcl.2007.11.056  0.744
2008 Gunatilleke SS, Barrios AM. Tuning the Au(I)-mediated inhibition of cathepsin B through ligand substitutions. Journal of Inorganic Biochemistry. 102: 555-63. PMID 18164406 DOI: 10.1016/J.Jinorgbio.2007.10.019  0.757
2007 Mitra S, Barrios AM. A series of peptide-based, fluorogenic probes for protein tyrosine phosphatase activity. Analytical Biochemistry. 370: 249-51. PMID 17662953 DOI: 10.1016/J.Ab.2007.06.012  0.582
2006 Gunatilleke SS, Barrios AM. Inhibition of lysosomal cysteine proteases by a series of Au(I) complexes: a detailed mechanistic investigation. Journal of Medicinal Chemistry. 49: 3933-7. PMID 16789749 DOI: 10.1021/Jm060158F  0.776
2005 Mitra S, Barrios AM. Highly sensitive peptide-based probes for protein tyrosine phosphatase activity utilizing a fluorogenic mimic of phosphotyrosine. Bioorganic & Medicinal Chemistry Letters. 15: 5142-5. PMID 16203147 DOI: 10.1016/J.Bmcl.2005.08.054  0.569
2004 Chircorian A, Barrios AM. Inhibition of lysosomal cysteine proteases by chrysotherapeutic compounds: a possible mechanism for the antiarthritic activity of Au(I). Bioorganic & Medicinal Chemistry Letters. 14: 5113-6. PMID 15380210 DOI: 10.1016/J.Bmcl.2004.07.073  0.499
2002 Barrios AM, Craik CS. Scanning the prime-site substrate specificity of proteolytic enzymes: a novel assay based on ligand-enhanced lanthanide ion fluorescence. Bioorganic & Medicinal Chemistry Letters. 12: 3619-23. PMID 12443789 DOI: 10.1016/S0960-894X(02)00786-2  0.361
2001 Barrios AM, Lippard SJ. Decomposition of alkyl-substituted urea molecules at a hydroxide-bridged dinickel center Inorganic Chemistry. 40: 1250-1255. PMID 11300826 DOI: 10.1021/Ic000933W  0.316
2001 Barrios AM, Lippard SJ. Phthalazine-based dinucleating ligands afford dinuclear centers often encountered in metalloenzyme active sites Inorganic Chemistry. 40: 1060-1064. PMID 11259020 DOI: 10.1021/Ic000889K  0.306
1998 LeCloux DD, Barrios AM, Mizoguchi TJ, Lippard SJ. Modeling the diiron centers of non-heme iron enzymes. Preparation of sterically hindered diiron(II) tetracarboxylate complexes and their reactions with dioxygen Journal of the American Chemical Society. 120: 9001-9014. DOI: 10.1021/Ja981216S  0.304
Low-probability matches (unlikely to be authored by this person)
2015 Thorson MK, Ung P, Leaver FM, Corbin TS, Tuck KL, Graham B, Barrios AM. Lanthanide complexes as luminogenic probes to measure sulfide levels in industrial samples. Analytica Chimica Acta. 896: 160-5. PMID 26482000 DOI: 10.1016/J.Aca.2015.09.024  0.299
1999 LeCloux DD, Barrios AM, Lippard SJ. The reactivity of well defined diiron(III) peroxo complexes toward substrates: Addition to electrophiles and hydrocarbon oxidation Bioorganic and Medicinal Chemistry. 7: 763-772. PMID 10400329 DOI: 10.1016/S0968-0896(98)00270-3  0.296
2014 Stanford SM, Ahmed V, Barrios AM, Bottini N. Cellular biochemistry methods for investigating protein tyrosine phosphatases. Antioxidants & Redox Signaling. 20: 2160-78. PMID 24294920 DOI: 10.1089/Ars.2013.5731  0.295
1999 Barrios AM, Lippard SJ. Amide hydrolysis effected by a hydroxo-bridged dinickel(II) complex: Insights into the mechanism of urease Journal of the American Chemical Society. 121: 11751-11757. DOI: 10.1021/Ja992447H  0.292
2014 Qian Z, LaRochelle JR, Jiang B, Lian W, Hard RL, Selner NG, Luechapanichkul R, Barrios AM, Pei D. Early endosomal escape of a cyclic cell-penetrating peptide allows effective cytosolic cargo delivery. Biochemistry. 53: 4034-46. PMID 24896852 DOI: 10.1021/Bi5004102  0.289
2000 Barrios AM, Lippard SJ. Interaction of urea with a hydroxide-bridged dinuclear nickel center: An alternative model for the mechanism of urease Journal of the American Chemical Society. 122: 9172-9177. DOI: 10.1021/Ja000202V  0.282
2003 Barrios AM, Craik CS. Ligand-enhanced lanthanide ion fluorescence as a probe for proteolytic activity and specificity Journal of Inorganic Biochemistry. 96: 99. DOI: 10.1016/S0162-0134(03)80564-0  0.281
2017 Aulsebrook ML, Biswas S, Leaver FM, Grace MR, Graham B, Barrios AM, Tuck KL. A luminogenic lanthanide-based probe for the highly selective detection of nanomolar sulfide levels in aqueous samples. Chemical Communications (Cambridge, England). PMID 28361130 DOI: 10.1039/C7Cc01764B  0.277
2000 He C, Barrios AM, Lee D, Kuzelka J, Davydov RM, Lippard SJ. Diiron complexes of 1,8-naphthyridine-based dinucleating ligands as models for hemerythrin Journal of the American Chemical Society. 122: 12683-12690. DOI: 10.1021/Ja0026861  0.262
1995 Liu G, Bruenger FW, Barrios AM, Miller SC. Synthesis of 2-Alkyl-3-Hydroxy-4-Pyridinone-Ribonucleosides, Potential Oral Iron Chelators Nucleosides and Nucleotides. 14: 1901-1904. DOI: 10.1080/15257779508010712  0.254
2006 Barrios AM. Intracellular metal detectors. Acs Chemical Biology. 1: 67-8. PMID 17163644 DOI: 10.1021/Cb600080A  0.234
2021 Fulo HF, Rueb NJ, Gaston R, Batsomboon P, Ahmed KT, Barrios AM, Dudley GB. Synthesis of illudalic acid and analogous phosphatase inhibitors. Organic & Biomolecular Chemistry. PMID 34847212 DOI: 10.1039/d1ob02106k  0.227
2013 Barrios AM, Cohen SM, Lim MH. Medicinal inorganic chemistry: a web themed issue. Chemical Communications (Cambridge, England). 49: 5910-1. PMID 23715532 DOI: 10.1039/C3Cc90159A  0.218
2021 Mathis CL, Barrios AM. Histidine phosphorylation in metalloprotein binding sites. Journal of Inorganic Biochemistry. 225: 111606. PMID 34555600 DOI: 10.1016/j.jinorgbio.2021.111606  0.177
2022 Blake MR, Gardner RT, Jin H, Staffenson MA, Rueb NJ, Barrios AM, Dudley GB, Cohen MS, Habecker BA. Small Molecules Targeting PTPσ-Trk Interactions Promote Sympathetic Nerve Regeneration. Acs Chemical Neuroscience. PMID 35156811 DOI: 10.1021/acschemneuro.1c00854  0.125
2014 Diez M, Diaz A, Garriga C, Pons M, Ten A, Marcos H, Gutierrez G, Moreno S, Gonzalez-Garcia J, Barrios A, Arponen S, Garcia M, Royo M, Toledo J, Gonzalez G, et al. A low-cost, sustainable, second generation system for surveillance of people living with HIV in Spain: 10-year trends in behavioural and clinical indicators, 2002 to 2011. Euro Surveillance : Bulletin EuropéEn Sur Les Maladies Transmissibles = European Communicable Disease Bulletin. 19. PMID 24871758  0.065
2012 Jiménez BC, Cuadros-Tito P, Ruiz-Giardin JM, Rojo-Marcos G, Cuadros-González J, Canalejo E, Cabello N, San Martín JV, Barrios AM, Hinojosa J, Molina L. Imported malaria in pregnancy in Madrid Malaria Journal. 11. PMID 22494463 DOI: 10.1186/1475-2875-11-112  0.055
2015 Diaz A, Ten A, Marcos H, Gutiérrez G, González-García J, Moreno S, Barrios AM, Arponen S, Portillo Á, Serrano R, García MT, Pérez JL, Toledo J, Royo MC, González G, et al. [Factors determining irregular attendance to follow-up visits among human immunodeficiency virus patients: results of the hospital survey of patients infected with human immunodeficiency virus]. Enfermedades Infecciosas Y Microbiología ClíNica. 33: 324-30. PMID 25444044 DOI: 10.1016/j.eimc.2014.07.009  0.027
2013 Ruiz-Giardin JM, Jimenez BC, Martin RM, Ortiz J, Condori Arenas MH, Sanmartin JV, Cabello N, Barrios AM, Rejas D, Fuentes Salazar M, Jaquetti J. Clinical diagnostic accuracy of suspected sources of bacteremia and its effect on mortality. European Journal of Internal Medicine. 24: 541-5. PMID 23768564 DOI: 10.1016/j.ejim.2013.05.010  0.013
2018 Ozturk E, Barrios A, Sun C, Rajabi S, Munoa J. Robotic assisted milling for increased productivity Cirp Annals. 67: 427-430. DOI: 10.1016/J.CIRP.2018.04.031  0.01
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