Joseph Loscalzo - Publications

Affiliations: 
Boston University, Boston, MA, United States 
Area:
Molecular Biology, Biochemistry

164 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 He H, Mulhern RM, Oldham WM, Xiao W, Lin YD, Liao R, Loscalzo J. L-2-Hydroxyglutarate Protects Against Cardiac Injury via Metabolic Remodeling. Circulation Research. 101161CIRCRESAHA1223. PMID 36043417 DOI: 10.1161/CIRCRESAHA.122.321227  0.718
2022 Pandey AK, Waldeck-Weiermair M, Wells QS, Xiao W, Yadav S, Eroglu E, Michel T, Loscalzo J. Expression of CD70 Modulates NO and Redox Status in Endothelial Cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 101161ATVBAHA1223178. PMID 35924558 DOI: 10.1161/ATVBAHA.122.317866  0.739
2021 Xiao W, Oldham WM, Priolo C, Pandey AK, Loscalzo J. Immunometabolic Endothelial Phenotypes: Integrating Inflammation and Glucose Metabolism. Circulation Research. PMID 33890812 DOI: 10.1161/CIRCRESAHA.120.318805  0.729
2019 Xiao W, Loscalzo J. Metabolic Responses to Reductive Stress. Antioxidants & Redox Signaling. PMID 31218894 DOI: 10.1089/Ars.2019.7803  0.745
2019 Napoli C, Benincasa G, Loscalzo J. Epigenetic Inheritance Underlying Pulmonary Arterial Hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA118312262. PMID 30727752 DOI: 10.1161/Atvbaha.118.312262  0.304
2019 Leopold JA, Loscalzo J. Oxidative mechanisms and atherothrombotic cardiovascular disease. Drug Discovery Today. Therapeutic Strategies. 5: 5-13. PMID 21048889 DOI: 10.1016/J.Ddstr.2008.02.001  0.36
2019 Upchurch GR, Leopold JA, Welch GN, Loscalzo J. Nitric Oxide Alters Human Microvascular Endothelial Cell Response to Cyclic Strain. Journal of Cardiovascular Pharmacology and Therapeutics. 3: 135-142. PMID 10684491 DOI: 10.1177/107424849800300206  0.32
2018 Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, ... ... Loscalzo J, et al. NEDD9 targets to promote endothelial fibrosis and pulmonary arterial hypertension. Science Translational Medicine. 10. PMID 29899023 DOI: 10.1126/Scitranslmed.Aap7294  0.312
2018 Loscalzo J. Nitric Oxide Signaling and Atherothrombosis Redux: Evidence From Experiments of Nature and Implications for Therapy. Circulation. 137: 233-236. PMID 29335284 DOI: 10.1161/Circulationaha.117.032901  0.36
2018 Loscalzo J. Nitroso-oxidative stress and cardiovascular disease Free Radical Biology and Medicine. 120: S12-S13. DOI: 10.1016/J.Freeradbiomed.2018.04.055  0.363
2017 Divakaran S, Loscalzo J. The Role of Nitroglycerin and Other Nitrogen Oxides in Cardiovascular Therapeutics. Journal of the American College of Cardiology. 70: 2393-2410. PMID 29096811 DOI: 10.1016/J.Jacc.2017.09.1064  0.355
2017 Xiao W, Wang RS, Handy DE, Loscalzo J. NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism. Antioxidants & Redox Signaling. PMID 28648096 DOI: 10.1089/Ars.2017.7216  0.738
2016 Handy DE, Loscalzo J. Responses to Reductive Stress in the Cardiovascular System. Free Radical Biology & Medicine. PMID 27940350 DOI: 10.1016/J.Freeradbiomed.2016.12.006  0.375
2016 Loscalzo J. Adaptions to Hypoxia and Redox Stress: Essential Concepts Confounded by Misleading Terminology. Circulation Research. 119: 511-3. PMID 27492841 DOI: 10.1161/Circresaha.116.309394  0.33
2016 Garmaroudi FS, Handy DE, Liu YY, Loscalzo J. Systems Pharmacology and Rational Polypharmacy: Nitric Oxide-Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case. Plos Computational Biology. 12: e1004822. PMID 26985825 DOI: 10.1371/Journal.Pcbi.1004822  0.31
2015 Barroso M, Kao D, Blom HJ, Tavares de Almeida I, Castro R, Loscalzo J, Handy DE. S-adenosylhomocysteine induces inflammation through NFkB: A possible role for EZH2 in endothelial cell activation. Biochimica Et Biophysica Acta. 1862: 82-92. PMID 26506125 DOI: 10.1016/J.Bbadis.2015.10.019  0.331
2015 Steinhorn BS, Loscalzo J, Michel T. Nitroglycerin and Nitric Oxide--A Rondo of Themes in Cardiovascular Therapeutics. The New England Journal of Medicine. 373: 277-80. PMID 26176386 DOI: 10.1056/Nejmsr1503311  0.314
2015 Loscalzo J. The role of oxidative stress in vascular pathobiology Ijc Metabolic & Endocrine. 7: 3. DOI: 10.1016/J.Ijcme.2015.05.007  0.326
2014 Loscalzo J. Redox Dysregulation in Vascular Pathobiology. Free Radical Biology & Medicine. 75: S2. PMID 26461304 DOI: 10.1016/J.Freeradbiomed.2014.10.597  0.386
2014 Ridker PM, Chasman DI, Rose L, Loscalzo J, Elias JA. Plasma levels of the proinflammatory chitin-binding glycoprotein YKL-40, variation in the chitinase 3-like 1 gene (CHI3L1), and incident cardiovascular events. Journal of the American Heart Association. 3: e000897. PMID 24958781 DOI: 10.1161/Jaha.114.000897  0.314
2014 Barroso M, Florindo C, Kalwa H, Silva Z, Turanov AA, Carlson BA, de Almeida IT, Blom HJ, Gladyshev VN, Hatfield DL, Michel T, Castro R, Loscalzo J, Handy DE. Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression. The Journal of Biological Chemistry. 289: 15350-62. PMID 24719327 DOI: 10.1074/Jbc.M114.549782  0.361
2013 Handy DE, Loscalzo J, Leopold JA. Systems analysis of oxidant stress in the vasculature. Iubmb Life. 65: 911-20. PMID 24265198 DOI: 10.1002/Iub.1221  0.321
2013 Loscalzo J. The identification of nitric oxide as endothelium-derived relaxing factor. Circulation Research. 113: 100-3. PMID 23833290 DOI: 10.1161/Circresaha.113.301577  0.343
2013 Joseph J, Loscalzo J. Selenistasis: epistatic effects of selenium on cardiovascular phenotype. Nutrients. 5: 340-58. PMID 23434902 DOI: 10.3390/Nu5020340  0.343
2012 Zhang Z, Yang Z, Zhu B, Hu J, Liew CW, Zhang Y, Leopold JA, Handy DE, Loscalzo J, Stanton RC. Increasing glucose 6-phosphate dehydrogenase activity restores redox balance in vascular endothelial cells exposed to high glucose. Plos One. 7: e49128. PMID 23185302 DOI: 10.1371/Journal.Pone.0049128  0.305
2012 White K, Loscalzo J, Chan SY. Holding our breath: The emerging and anticipated roles of microRNA in pulmonary hypertension. Pulmonary Circulation. 2: 278-90. PMID 23130098 DOI: 10.4103/2045-8932.101395  0.301
2012 Maron BA, Zhang YY, White K, Chan SY, Handy DE, Mahoney CE, Loscalzo J, Leopold JA. Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension. Circulation. 126: 963-74. PMID 22787113 DOI: 10.1161/Circulationaha.112.094722  0.343
2012 Ueland PM, Loscalzo J. Homocysteine and cardiovascular risk: the perils of reductionism in a complex system. Clinical Chemistry. 58: 1623-5. PMID 22623744 DOI: 10.1373/Clinchem.2012.187286  0.355
2012 Wang X, Cui L, Joseph J, Jiang B, Pimental D, Handy DE, Liao R, Loscalzo J. Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress. Journal of Molecular and Cellular Cardiology. 52: 753-60. PMID 22227328 DOI: 10.1016/J.Yjmcc.2011.12.009  0.362
2012 Barroso M, Rocha MS, Esse R, Gonçalves I, Gomes AQ, Teerlink T, Jakobs C, Blom HJ, Loscalzo J, Rivera I, de Almeida IT, Castro R. Cellular hypomethylation is associated with impaired nitric oxide production by cultured human endothelial cells. Amino Acids. 42: 1903-11. PMID 21614558 DOI: 10.1007/S00726-011-0916-0  0.35
2011 Liberman M, Johnson RC, Handy DE, Loscalzo J, Leopold JA. Bone morphogenetic protein-2 activates NADPH oxidase to increase endoplasmic reticulum stress and human coronary artery smooth muscle cell calcification. Biochemical and Biophysical Research Communications. 413: 436-41. PMID 21907184 DOI: 10.1016/J.Bbrc.2011.08.114  0.315
2011 Jin RC, Mahoney CE, Coleman Anderson L, Ottaviano F, Croce K, Leopold JA, Zhang YY, Tang SS, Handy DE, Loscalzo J. Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo. Circulation. 123: 1963-73. PMID 21518981 DOI: 10.1161/Circulationaha.110.000034  0.78
2011 Lubos E, Loscalzo J, Handy DE. Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities. Antioxidants & Redox Signaling. 15: 1957-97. PMID 21087145 DOI: 10.1089/Ars.2010.3586  0.34
2010 Jin RC, Loscalzo J. Vascular Nitric Oxide: Formation and Function. Journal of Blood Medicine. 2010: 147-162. PMID 21572574 DOI: 10.2147/Jbm.S7000  0.381
2010 Hu W, Jin R, Zhang J, You T, Peng Z, Ge X, Bronson RT, Halperin JA, Loscalzo J, Qin X. The critical roles of platelet activation and reduced NO bioavailability in fatal pulmonary arterial hypertension in a murine hemolysis model. Blood. 116: 1613-22. PMID 20511540 DOI: 10.1182/Blood-2010-01-267112  0.322
2010 Xu Y, Zhang Z, Hu J, Stillman IE, Leopold JA, Handy DE, Loscalzo J, Stanton RC. Glucose-6-phosphate dehydrogenase-deficient mice have increased renal oxidative stress and increased albuminuria. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 609-16. PMID 19805580 DOI: 10.1096/Fj.09-135731  0.303
2010 Loscalzo J. Antioxidant enzyme deficiencies and vascular disease Expert Review of Endocrinology and Metabolism. 5: 15-18. DOI: 10.1586/Eem.09.41  0.34
2009 Loscalzo J. Homocysteine-mediated thrombosis and angiostasis in vascular pathobiology Journal of Clinical Investigation. 119: 3203-3205. PMID 19841539 DOI: 10.1172/Jci40924  0.32
2009 Leopold JA, Loscalzo J. Oxidative risk for atherothrombotic cardiovascular disease Free Radical Biology and Medicine. 47: 1673-1706. PMID 19751821 DOI: 10.1016/J.Freeradbiomed.2009.09.009  0.362
2009 Qin X, Hu W, Song W, Blair P, Wu G, Hu X, Song Y, Bauer S, Feelisch M, Leopold JA, Loscalzo J, Halperin JA. Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice. American Journal of Hematology. 84: 221-7. PMID 19229985 DOI: 10.1002/Ajh.21363  0.315
2009 Ottaviano FG, Tang SS, Handy DE, Loscalzo J. Regulation of the extracellular antioxidant selenoprotein plasma glutathione peroxidase (GPx-3) in mammalian cells. Molecular and Cellular Biochemistry. 327: 111-26. PMID 19219623 DOI: 10.1007/S11010-009-0049-X  0.772
2009 Maron BA, Zhang YY, Handy DE, Beuve A, Tang SS, Loscalzo J, Leopold JA. Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells. The Journal of Biological Chemistry. 284: 7665-72. PMID 19141618 DOI: 10.1074/Jbc.M809460200  0.354
2009 Maron BA, Loscalzo J. The treatment of hyperhomocysteinemia. Annual Review of Medicine. 60: 39-54. PMID 18729731 DOI: 10.1146/Annurev.Med.60.041807.123308  0.307
2008 Loscalzo J. Paraoxonase and coronary heart disease risk: language misleads, linkage misinforms, function clarifies Circulation. Cardiovascular Genetics. 1: 79-80. PMID 20031548 DOI: 10.1161/Circgenetics.108.837179  0.302
2008 Lubos E, Handy DE, Loscalzo J. Role of oxidative stress and nitric oxide in atherothrombosis. Frontiers in Bioscience : a Journal and Virtual Library. 13: 5323-44. PMID 18508590 DOI: 10.2741/3084  0.364
2008 Ottaviano FG, Handy DE, Loscalzo J. Redox regulation in the extracellular environment. Circulation Journal : Official Journal of the Japanese Circulation Society. 72: 1-16. PMID 18159092 DOI: 10.1253/Circj.72.1  0.782
2008 Voetsch B, Jin RC, Bierl C, Deus-Silva L, Camargo EC, Annichino-Bizacchi JM, Handy DE, Loscalzo J. Role of promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene as a risk factor for cerebral venous thrombosis. Stroke; a Journal of Cerebral Circulation. 39: 303-7. PMID 18096833 DOI: 10.1161/Strokeaha.107.490094  0.78
2008 Chan SY, Loscalzo J. Pathogenic mechanisms of pulmonary arterial hypertension Journal of Molecular and Cellular Cardiology. 44: 14-30. PMID 17950310 DOI: 10.1016/J.Yjmcc.2007.09.006  0.309
2007 Lubos E, Loscalzo J, Handy DE. Homocysteine and glutathione peroxidase-1. Antioxidants & Redox Signaling. 9: 1923-40. PMID 17822368 DOI: 10.1089/Ars.2007.1771  0.404
2007 Rajasekaran NS, Connell P, Christians ES, Yan LJ, Taylor RP, Orosz A, Zhang XQ, Stevenson TJ, Peshock RM, Leopold JA, Barry WH, Loscalzo J, Odelberg SJ, Benjamin IJ. Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice. Cell. 130: 427-39. PMID 17693254 DOI: 10.1016/J.Cell.2007.06.044  0.312
2007 Dardik R, Krapp T, Rosenthal E, Loscalzo J, Inbal A. Effect of FXIII on monocyte and fibroblast function. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 19: 113-20. PMID 17310105 DOI: 10.1159/000099199  0.301
2007 Leopold JA, Dam A, Maron BA, Scribner AW, Liao R, Handy DE, Stanton RC, Pitt B, Loscalzo J. Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nature Medicine. 13: 189-97. PMID 17273168 DOI: 10.1038/Nm1545  0.36
2007 Voetsch B, Jin RC, Bierl C, Benke KS, Kenet G, Simioni P, Ottaviano F, Damasceno BP, Annichino-Bizacchi JM, Handy DE, Loscalzo J. Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children. Stroke; a Journal of Cerebral Circulation. 38: 41-9. PMID 17122425 DOI: 10.1161/01.Str.0000252027.53766.2B  0.768
2007 Johnson RC, Leopold JA, Loscalzo J. Vascular calcification: pathobiological mechanisms and clinical implications. Circulation Research. 99: 1044-59. PMID 17095733 DOI: 10.1161/01.Res.0000249379.55535.21  0.329
2007 Ottaviano FG, Handy DE, Loscalzo J. Overexpression and Purification of the Antioxidant Selenoprotein Plasma Glutathione Peroxidase The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A649-B  0.768
2006 Handy DE, Loscalzo J. Nitric oxide and posttranslational modification of the vascular proteome: S-nitrosation of reactive thiols Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 1207-1214. PMID 16543494 DOI: 10.1161/01.Atv.0000217632.98717.A0  0.324
2006 Dardik R, Leor J, Skutelsky E, Castel D, Holbova R, Schiby G, Shaish A, Dickneite G, Loscalzo J, Inbal A. Evaluation of the pro-angiogenic effect of factor XIII in heterotopic mouse heart allografts and FXIII-deficient mice. Thrombosis and Haemostasis. 95: 546-50. PMID 16525585 DOI: 10.1160/Th05-06-0409  0.302
2006 Loscalzo J. ATVB in focus: Nitric oxide redux Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 696. DOI: 10.1161/01.Atv.0000209519.12258.74  0.328
2005 Galasso G, Schiekofer S, Sato K, Shibata R, Handy DE, Ouchi N, Leopold JA, Loscalzo J, Walsh K. Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction. Circulation Research. 98: 254-61. PMID 16373599 DOI: 10.1161/01.Res.0000200740.57764.52  0.355
2005 Loscalzo J, Voetsch B, Liao R, Leopold J. Genetic determinants of vascular oxidant stress and endothelial dysfunction. Congestive Heart Failure (Greenwich, Conn.). 11: 73-9. PMID 15860972 DOI: 10.1111/J.1527-5299.2005.03854.X  0.367
2005 Jin RC, Voetsch B, Loscalzo J. Endogenous mechanisms of inhibition of platelet function. Microcirculation (New York, N.Y. : 1994). 12: 247-58. PMID 15814434 DOI: 10.1080/10739680590925493  0.307
2005 Zhang Y, Handy DE, Loscalzo J. Adenosine-dependent induction of glutathione peroxidase 1 in human primary endothelial cells and protection against oxidative stress. Circulation Research. 96: 831-7. PMID 15802613 DOI: 10.1161/01.Res.0000164401.21929.Cf  0.35
2005 Leopold JA, Loscalzo J. Oxidative enzymopathies and vascular disease - ATVB in focus Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 1332-1340. PMID 15790928 DOI: 10.1161/01.Atv.0000163846.51473.09  0.37
2005 Handy DE, Zhang Y, Loscalzo J. Homocysteine down-regulates cellular glutathione peroxidase (GPx1) by decreasing translation. The Journal of Biological Chemistry. 280: 15518-25. PMID 15734734 DOI: 10.1074/Jbc.M501452200  0.317
2005 Napoli C, Loscalzo J. New challenges for ACE-inhibitors in vascular diseases Drug Design Reviews Online. 2: 485-493. DOI: 10.2174/156726905774641190  0.313
2004 Loscalzo J. L-arginine and atherothrombosis Journal of Nutrition. 134. PMID 15465788 DOI: 10.1093/Jn/134.10.2798S  0.341
2004 Voetsch B, Jin RC, Loscalzo J. Nitric oxide insufficiency and atherothrombosis. Histochemistry and Cell Biology. 122: 353-67. PMID 15338226 DOI: 10.1007/S00418-004-0675-Z  0.363
2004 Faxon DP, Creager MA, Smith SC, Pasternak RC, Olin JW, Bettmann MA, Criqui MH, Milani RV, Loscalzo J, Kaufman JA, Jones DW, Pearce WH. Atherosclerotic Vascular Disease Conference: Executive summary: Atherosclerotic Vascular Disease Conference proceeding for healthcare professionals from a special writing group of the American Heart Association. Circulation. 109: 2595-604. PMID 15173041 DOI: 10.1161/01.Cir.0000128517.52533.Db  0.306
2004 Bierl C, Voetsch B, Jin RC, Handy DE, Loscalzo J. Determinants of human plasma glutathione peroxidase (GPx-3) expression. The Journal of Biological Chemistry. 279: 26839-45. PMID 15096516 DOI: 10.1074/Jbc.M401907200  0.76
2004 Napoli C, Loscalzo J. Nitric Oxide and Other Novel Therapies for Pulmonary Hypertension Journal of Cardiovascular Pharmacology and Therapeutics. 9: 1-8. PMID 15094962 DOI: 10.1177/107424840400900I101  0.336
2004 Voetsch B, Loscalzo J. Genetics of thrombophilia: Impact on atherogenesis Current Opinion in Lipidology. 15: 129-143. PMID 15017356 DOI: 10.1097/00041433-200404000-00006  0.332
2004 Heydrick SJ, Weiss N, Thomas SR, Cap AP, Pimentel DR, Loscalzo J, Keaney JF. L-Homocysteine and L-homocystine stereospecifically induce endothelial nitric oxide synthase-dependent lipid peroxidation in endothelial cells. Free Radical Biology & Medicine. 36: 632-40. PMID 14980706 DOI: 10.1016/J.Freeradbiomed.2003.12.001  0.567
2004 Scribner AW, Loscalzo J, Napoli C. The effect of angiotensin-converting enzyme inhibition on endothelial function and oxidant stress. European Journal of Pharmacology. 482: 95-9. PMID 14660009 DOI: 10.1016/J.Ejphar.2003.10.002  0.353
2004 Weiss N, Heydrick SJ, Postea O, Keller C, Keaney JF, Loscalzo J. Influence of hyperhomocysteinemia on the cellular redox state--impact on homocysteine-induced endothelial dysfunction. Clinical Chemistry and Laboratory Medicine. 41: 1455-61. PMID 14656025 DOI: 10.1515/Cclm.2003.223  0.386
2004 Voetsch B, Loscalzo J. Genetic Determinants of Arterial Thrombosis Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 216-229. PMID 14615395 DOI: 10.1161/01.Atv.0000107402.79771.Fc  0.32
2003 Loscalzo J. The evolution of the discipline of vascular biology: From systems physiology to molecular biology to molecular systems Circulation Research. 93: 583-585. PMID 14525918 DOI: 10.1161/01.Res.0000095381.50007.D1  0.306
2003 Walford G, Loscalzo J. Nitric oxide in vascular biology Journal of Thrombosis and Haemostasis. 1: 2112-2118. PMID 14521592 DOI: 10.1046/J.1538-7836.2003.00345.X  0.341
2003 Eberhardt RT, McMahon L, Duffy SJ, Steinberg MH, Perrine SP, Loscalzo J, Coffman JD, Vita JA. Sickle cell anemia is associated with reduced nitric oxide bioactivity in peripheral conduit and resistance vessels. American Journal of Hematology. 74: 104-11. PMID 14508796 DOI: 10.1002/Ajh.10387  0.313
2003 Loscalzo J. Oxidant stress: A key determinant of atherothrombosis Biochemical Society Transactions. 31: 1059-1061. PMID 14505479 DOI: 10.1042/Bst0311059  0.37
2003 Jain M, Brenner DA, Cui L, Lim CC, Wang B, Pimentel DR, Koh S, Sawyer DB, Leopold JA, Handy DE, Loscalzo J, Apstein CS, Liao R. Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. Circulation Research. 93: e9-16. PMID 12829617 DOI: 10.1161/01.Res.0000083489.83704.76  0.33
2003 Handy DE, Loscalzo J. Homocysteine and atherothrombosis: Diagnosis and treatment Current Atherosclerosis Reports. 5: 276-283. PMID 12793968 DOI: 10.1007/S11883-003-0050-X  0.307
2003 Leopold JA, Walker J, Scribner AW, Voetsch B, Zhang YY, Loscalzo AJ, Stanton RC, Loscalzo J. Glucose-6-phosphate dehydrogenase modulates vascular endothelial growth factor-mediated angiogenesis. The Journal of Biological Chemistry. 278: 32100-6. PMID 12777375 DOI: 10.1074/Jbc.M301293200  0.335
2003 Nedeljkovic ZS, Gokce N, Loscalzo J. Mechanisms of oxidative stress and vascular dysfunction. Postgraduate Medical Journal. 79: 195-199; quiz 198-20. PMID 12743334 DOI: 10.1136/Pmj.79.930.195  0.359
2003 Leopold JA, Zhang YY, Scribner AW, Stanton RC, Loscalzo J. Glucose-6-phosphate dehydrogenase overexpression decreases endothelial cell oxidant stress and increases bioavailable nitric oxide. Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 411-7. PMID 12615686 DOI: 10.1161/01.Atv.0000056744.26901.Ba  0.358
2003 Weiss N, Keller C, Hoffmann U, Loscalzo J. Endothelial dysfunction and atherothrombosis in mild hyperhomocysteinemia. Vascular Medicine (London, England). 7: 227-39. PMID 12553746 DOI: 10.1191/1358863X02Vm428Ra  0.382
2003 Loscalzo J. Adverse effects of supplemental L-arginine in atherosclerosis: Consequences of methylation stress in a complex catabolism? Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 3-5. PMID 12524215 DOI: 10.1161/01.Atv.0000040860.71626.9D  0.356
2003 Russo G, Leopold JA, Loscalzo J. Vasoactive substances: nitric oxide and endothelial dysfunction in atherosclerosis. Vascular Pharmacology. 38: 259-69. PMID 12487030 DOI: 10.1016/S1537-1891(02)00250-1  0.363
2003 Freedman JE, Loscalzo J. Nitric oxide and its relationship to thrombotic disorders Journal of Thrombosis and Haemostasis. 1: 1183-1188. DOI: 10.1046/J.1538-7836.2003.00180.X  0.324
2003 Willoughby SR, Cap AP, Horowitz JD, Loscalzo J. Inhibition of human platelet aggregation by nitric oxide species: Differential effects of L-cysteine Heart, Lung and Circulation. 12: A56. DOI: 10.1046/J.1443-9506.2003.02307.X  0.52
2002 Willoughby S, Holmes A, Loscalzo J. Platelets and cardiovascular disease European Journal of Cardiovascular Nursing. 1: 273-288. PMID 14622657 DOI: 10.1016/S1474-5151(02)00038-5  0.305
2002 Loscalzo J. Oxidative stress in endothelial cell dysfunction and thrombosis Pathophysiology of Haemostasis and Thrombosis. 32: 359-360. PMID 13679676 DOI: 10.1159/000073600  0.38
2002 Napoli C, Lerman LO, de Nigris F, Loscalzo J, Ignarro LJ. Glycoxidized low-density lipoprotein downregulates endothelial nitricoxide synthase in human coronary cells. Journal of the American College of Cardiology. 40: 1515-22. PMID 12392844 DOI: 10.1016/S0735-1097(02)02306-9  0.323
2002 Forgione MA, Cap A, Liao R, Moldovan NI, Eberhardt RT, Lim CC, Jones J, Goldschmidt-Clermont PJ, Loscalzo J. Heterozygous cellular glutathione peroxidase deficiency in the mouse: abnormalities in vascular and cardiac function and structure. Circulation. 106: 1154-8. PMID 12196344 DOI: 10.1161/01.Cir.0000026820.87824.6A  0.559
2002 Vita JA, Loscalzo J. Shouldering the risk factor burden: Infection, atherosclerosis, and the vascular endothelium Circulation. 106: 164-166. PMID 12105150 DOI: 10.1161/01.Cir.0000023452.26135.34  0.353
2002 Ruberg FL, Leopold JA, Loscalzo J. Atherothrombosis: plaque instability and thrombogenesis. Progress in Cardiovascular Diseases. 44: 381-94. PMID 12024336 DOI: 10.1053/Pcad.2002.123469  0.304
2002 Forgione MA, Weiss N, Heydrick S, Cap A, Klings ES, Bierl C, Eberhardt RT, Farber HW, Loscalzo J. Cellular glutathione peroxidase deficiency and endothelial dysfunction American Journal of Physiology - Heart and Circulatory Physiology. 282: H1255-H1261. PMID 11893559 DOI: 10.1152/Ajpheart.00598.2001  0.79
2002 Loscalzo J. Perspective: Homocysteine and dementias New England Journal of Medicine. 346: 466-468. PMID 11844846 DOI: 10.1056/Nejm200202143460702  0.339
2002 Weiss N, Heydrick S, Zhang YY, Bierl C, Cap A, Loscalzo J. Cellular redox state and endothelial dysfunction in mildly hyperhomocysteinemic cystathionine beta-synthase-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 22: 34-41. PMID 11788458 DOI: 10.1161/Hq1201.100456  0.788
2002 Walker JL, Loscalzo J, Zhang YY. 5-Lipoxygenase and human pulmonary artery endothelial cell proliferation. American Journal of Physiology. Heart and Circulatory Physiology. 282: H585-93. PMID 11788406 DOI: 10.1152/Ajpheart.00003.2001  0.303
2002 Ignarro LJ, Napoli C, Loscalzo J. Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: An overview Circulation Research. 90: 21-28. PMID 11786514 DOI: 10.1161/Hh0102.102330  0.312
2001 Weiss N, Zhang YY, Heydrick S, Bierl C, Loscalzo J. Overexpression of cellular glutathione peroxidase rescues homocyst(e)ine-induced endothelial dysfunction. Proceedings of the National Academy of Sciences of the United States of America. 98: 12503-8. PMID 11606774 DOI: 10.1073/Pnas.231428998  0.768
2001 Loscalzo J. An experiment of nature: Genetic L-arginine deficiency and NO insufficiency Journal of Clinical Investigation. 108: 663-664. PMID 11544270 DOI: 10.1172/Jci13848  0.304
2001 Loscalzo J. Folate and nitrate-induced endothelial dysfunction: A simple treatment for a complex pathobiology Circulation. 104: 1086-1088. PMID 11535558 DOI: 10.1161/Circ.104.10.1086  0.37
2001 Upchurch GR, Goodman DG, Willoughby SR, Zhang YY, Welch GN, Freedman JE, Ye S, Costello CE, Loscalzo J. Heparin reacts with and inactivates nitric oxide Journal of Cardiovascular Pharmacology and Therapeutics. 6: 163-173. PMID 11509923 DOI: 10.1177/107424840100600208  0.308
2001 Loscalzo J. Inducible NO synthesis in the vasculature: Molecular context defines physiological response Arteriosclerosis, Thrombosis, and Vascular Biology. 21: 1259-1260. PMID 11498449 DOI: 10.1161/Atvb.21.8.1259  0.326
2001 Leopold JA, Cap A, Scribner AW, Stanton RC, Loscalzo J. Glucose-6-phosphate dehydrogenase deficiency promotes endothelial oxidant stress and decreases endothelial nitric oxide bioavailability. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 1771-3. PMID 11481225 DOI: 10.1096/Fj.00-0893Fje  0.558
2001 Loscalzo J. Nitric oxide insufficiency, platelet activation, and arterial thrombosis Circulation Research. 88: 756-762. PMID 11325866 DOI: 10.1161/Hh0801.089861  0.364
2001 Forgione MA, Leopold JA, Loscalzo J. Roles of endothelial dysfunction in coronary artery disease. Current Opinion in Cardiology. 15: 409-15. PMID 11198623 DOI: 10.1097/00001573-200011000-00007  0.33
2001 Maytin M, Leopold J, Loscalzo J. Oxidant stress in the vasculature. Current Atherosclerosis Reports. 1: 156-64. PMID 11122705 DOI: 10.1007/S11883-999-0012-Z  0.376
2000 Leopold JA, Loscalzo J. Clinical importance of understanding vascular biology Cardiology in Review. 8: 115-123. PMID 11174883 DOI: 10.1097/00045415-200008020-00009  0.311
2000 Leopold JA, Loscalzo J. Cyclic strain modulates resistance to oxidant stress by increasing G6PDH expression in smooth muscle cells American Journal of Physiology - Heart and Circulatory Physiology. 279. PMID 11045985 DOI: 10.1152/Ajpheart.2000.279.5.H2477  0.34
2000 Eberhardt RT, Forgione MA, Cap A, Leopold JA, Rudd MA, Trolliet M, Heydrick S, Stark R, Klings ES, Moldovan NI, Yaghoubi M, Goldschmidt-Clermont PJ, Farber HW, Cohen R, Loscalzo J. Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. The Journal of Clinical Investigation. 106: 483-91. PMID 10953023 DOI: 10.1172/Jci8342  0.366
2000 Yang Y, Loscalzo J. Regulation of tissue factor expression in human microvascular endothelial cells by nitric oxide Circulation. 101: 2144-2148. PMID 10801753 DOI: 10.1161/01.Cir.101.18.2144  0.36
2000 Loscalzo J. What we know and don't know about L-arginine and NO Circulation. 101: 2126-2129. PMID 10801749 DOI: 10.1161/01.Cir.101.18.2126  0.336
2000 Loscalzo J. Endothelium, Nitric Oxide, and Atherosclerosis: From Basic Mechanisms to Clinical Implications Circulation. 102. DOI: 10.1161/01.Cir.102.8.E51  0.351
1999 Hammerman SI, Klings ES, Hendra KP, Upchurch GR, Rishikof DC, Loscalzo J, Farber HW. Endothelial cell nitric oxide production in acute chest syndrome. The American Journal of Physiology. 277: H1579-92. PMID 10516198 DOI: 10.1152/Ajpheart.1999.277.4.H1579  0.372
1999 Kenet G, Freedman J, Shenkman B, Regina E, Brok-Simoni F, Holzman F, Vavva F, Brand N, Michelson A, Trolliet M, Loscalzo J, Inbal A. Plasma glutathione peroxidase deficiency and platelet insensitivity to nitric oxide in children with familial stroke. Arteriosclerosis, Thrombosis, and Vascular Biology. 19: 2017-23. PMID 10446087 DOI: 10.1161/01.Atv.19.8.2017  0.305
1999 Freedman JE, Sauter R, Battinelli EM, Ault K, Knowles C, Huang PL, Loscalzo J. Deficient platelet-derived nitric oxide and enhanced hemostasis in mice lacking the NOSIII gene. Circulation Research. 84: 1416-21. PMID 10381894 DOI: 10.1161/01.Res.84.12.1416  0.314
1999 Folts JD, Schafer AI, Loscalzo J, Willerson JT, Muller JE. A perspective on the potential problems with aspirin as an antithrombotic agent: a comparison of studies in an animal model with clinical trials. Journal of the American College of Cardiology. 33: 295-303. PMID 9973006 DOI: 10.1016/S0735-1097(98)00601-9  0.3
1999 Zai A, Rudd MA, Scribner AW, Loscalzo J. Cell-surface protein disulfide isomerase catalyzes transnitrosation and regulates intracellular transfer of nitric oxide. The Journal of Clinical Investigation. 103: 393-9. PMID 9927500 DOI: 10.1172/Jci4890  0.693
1999 Inbal A, Gurevitz O, Tamarin I, Eskaraev R, Chetrit A, Novicov I, Feldman M, Varon D, Eldar M, Loscalzo J. Unique Antiplatelet Effects of a Novel S-Nitrosoderivative of a Recombinant Fragment of von Willebrand Factor, AR545C: In Vitro and Ex Vivo Inhibition of Platelet Function Blood. 94: 1693-1700. DOI: 10.1182/Blood.V94.5.1693.417K32_1693_1700  0.3
1998 GRU, Ramdev N, Walsh MT, Loscalzo J. Prothrombotic Consequences of the Oxidation of Fibrinogen and their Inhibition by Aspirin Journal of Thrombosis and Thrombolysis. 5: 9-14. PMID 10608044 DOI: 10.1023/A:1008859729045  0.353
1998 Freedman JE, Ting B, Hankin B, Loscalzo J, Keaney JF, Vita JA. Impaired platelet production of nitric oxide predicts presence of acute coronary syndromes. Circulation. 98: 1481-6. PMID 9769300 DOI: 10.1161/01.Cir.98.15.1481  0.316
1998 Upchurch GR, Welch GN, Loscalzo J. The vascular biology of S-nitrosothiols, nitrosated derivatives of thiols. Vascular Medicine (London, England). 1: 25-33. PMID 9546910 DOI: 10.1177/1358863X9600100105  0.308
1997 Leopold JA, Loscalzo J. New developments in nitrosovasodilator therapy Vascular Medicine. 2: 190-202. PMID 9546968 DOI: 10.1177/1358863X9700200305  0.307
1997 Zhao Z, Francis CE, Welch G, Loscalzo J, Ravid K. Reduced glutathione prevents nitric oxide-induced apoptosis in vascular smooth muscle cells Biochimica Et Biophysica Acta - Molecular Cell Research. 1359: 143-152. PMID 9409811 DOI: 10.1016/S0167-4889(97)00093-1  0.323
1997 Freedman JE, Loscalzo J. Endothelial dysfunction and atherothrombotic occlusive disease. Drugs. 41-9; discussion 49-. PMID 9360851 DOI: 10.2165/00003495-199700543-00007  0.332
1997 Upchurch GR, Welch GN, Fabian AJ, Pigazzi A, Keaney JF, Loscalzo J. Stimulation of endothelial nitric oxide production by homocyst(e)ine. Atherosclerosis. 132: 177-85. PMID 9242963 DOI: 10.1016/S0021-9150(97)00090-7  0.332
1997 Upchurch GR, Welch GN, Fabian AJ, Freedman JE, Johnson JL, Keaney JF, Loscalzo J. Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. The Journal of Biological Chemistry. 272: 17012-7. PMID 9202015 DOI: 10.1074/Jbc.272.27.17012  0.365
1997 Welch GN, Upchurch GR, Loscalzo J. Homocysteine, oxidative stress, and vascular disease. Hospital Practice (1995). 32: 81-2, 85, 88-92. PMID 9194803 DOI: 10.1080/21548331.1997.11443510  0.36
1997 Loscalzo J. Nitric oxide binding and the adverse effects of cell-free hemoglobins: what makes us different from earthworms The Journal of Laboratory and Clinical Medicine. 129: 580-583. PMID 9178723 DOI: 10.1016/S0022-2143(97)90191-8  0.3
1997 Upchurch GR, Welch GN, Freedman JE, Fabian AJ, Pigazzi A, Scribner AM, Alpert CS, Keaney JF, Loscalzo J. High-dose heparin decreases nitric oxide production by cultured bovine endothelial cells. Circulation. 95: 2115-21. PMID 9133522 DOI: 10.1161/01.Cir.95.8.2115  0.34
1996 Michelson AD, Benoit SE, Furman MI, Breckwoldt WL, Rohrer MJ, Barnard MR, Loscalzo J. Effects of nitric oxide/EDRF on platelet surface glycoproteins. The American Journal of Physiology. 270: H1640-8. PMID 8928869 DOI: 10.1152/Ajpheart.1996.270.5.H1640  0.303
1996 Marks DS, Vita JA, Folts JD, Keaney JF, Welch GN, Loscalzo J. Inhibition of neointimal proliferation in rabbits after vascular injury by a single treatment with a protein adduct of nitric oxide. The Journal of Clinical Investigation. 96: 2630-8. PMID 8675628 DOI: 10.1172/Jci118328  0.32
1996 Upchurch GR, Welch GN, Loscalzo J. Homocysteine, EDRF, and endothelial function. The Journal of Nutrition. 126: 1290S-4S. PMID 8642473 DOI: 10.1093/Jn/126.Suppl_4.1290S  0.352
1996 Freedman JE, Loscalzo J, Benoit SE, Valeri CR, Barnard MR, Michelson AD. Decreased platelet inhibition by nitric oxide in two brothers with a history of arterial thrombosis. The Journal of Clinical Investigation. 97: 979-87. PMID 8613552 DOI: 10.1172/Jci118522  0.328
1996 Upchurch GR, Welch GN, Loscalzo J. S-nitrosothiols: chemistry, biochemistry, and biological actions. Advances in Pharmacology (San Diego, Calif.). 34: 343-9. PMID 8562444 DOI: 10.1016/S1054-3589(08)61096-0  0.318
1996 Loscalzo J. State-of-the-Art Review : Nitric Oxide and Restenosis Clinical and Applied Thrombosis/Hemostasis. 2: 7-10. DOI: 10.1177/107602969600200102  0.36
1996 Upchurch GR, Freedman JE, Zhang Y, Welch GN, Loscalzo J. Heparin reverses the antiplatelet effect of nitric oxide Journal of the American College of Cardiology. 27: 164. DOI: 10.1016/S0735-1097(96)80884-9  0.319
1995 Levy AP, Levy NS, Loscalzo J, Calderone A, Takahashi N, Yeo KT, Koren G, Colucci WS, Goldberg MA. Regulation of vascular endothelial growth factor in cardiac myocytes. Circulation Research. 76: 758-66. PMID 7728992 DOI: 10.1161/01.Res.76.5.758  0.303
1995 Freedman JE, Frei B, Welch GN, Loscalzo J. Glutathione peroxidase potentiates the inhibition of platelet function by S-nitrosothiols. The Journal of Clinical Investigation. 96: 394-400. PMID 7615810 DOI: 10.1172/Jci118047  0.322
1995 Loscalzo J, Welch G. Nitric oxide and its role in the cardiovascular system Progress in Cardiovascular Diseases. 38: 87-104. PMID 7568906 DOI: 10.1016/S0033-0620(05)80001-5  0.353
1995 Loscalzo J. Nitric oxide and vascular disease New England Journal of Medicine. 333: 251-253. PMID 7540723 DOI: 10.1056/Nejm199507273330410  0.34
1995 Freedman JE, Fabian A, Loscalzo J. Impaired EDRF production by endothelial cells exposed to fibrin monomer and FDP. The American Journal of Physiology. 268: C520-6. PMID 7532361 DOI: 10.1152/Ajpcell.1995.268.2.C520  0.334
1995 Welch G, Upchurch G, Loscalzo J. Nitric oxide as a vascular modulator Blood Reviews. 9: 262-269. DOI: 10.1016/S0268-960X(95)90017-9  0.357
1995 Freedman JE, Frei B, Welch GN, Loscalzo J. 407-3 Glutathione Peroxidase Prevents the Inactivation of Nitric Oxide and Restores the Inhibition of Platelet Function by S-Nitrosothiols Journal of the American College of Cardiology. 25: 2A. DOI: 10.1016/0735-1097(95)91474-C  0.346
1994 Keaney JF, Gaziano JM, Xu A, Frei B, Curran-Celentano J, Shwaery GT, Loscalzo J, Vita JA. Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits. Proceedings of the National Academy of Sciences of the United States of America. 90: 11880-4. PMID 8265642 DOI: 10.1073/Pnas.90.24.11880  0.329
1994 Rabbani LRE, Loscalzo J. Recent observations on the role of hemostatic determinants in the development of the atherothrombotic plaque Atherosclerosis. 105: 1-7. PMID 8155083 DOI: 10.1016/0021-9150(94)90002-7  0.302
1994 Welch G, Loscalzo J. Nitric oxide and the cardiovascular system Journal of Cardiac Surgery. 9: 361-371. PMID 8054733 DOI: 10.1111/J.1540-8191.1994.Tb00857.X  0.358
1994 Scharfstein JS, Keaney JF, Slivka A, Welch GN, Vita JA, Stamler JS, Loscalzo J. In vivo transfer of nitric oxide between a plasma protein-bound reservoir and low molecular weight thiols. The Journal of Clinical Investigation. 94: 1432-9. PMID 7929818 DOI: 10.1172/Jci117480  0.308
1994 Gaston B, Drazen JM, Loscalzo J, Stamler JS. The biology of nitrogen oxides in the airways American Journal of Respiratory and Critical Care Medicine. 149: 538-551. PMID 7508323 DOI: 10.1164/Ajrccm.149.2.7508323  0.32
1993 Keaney JF, Simon DI, Stamler JS, Jaraki O, Scharfstein J, Vita JA, Loscalzo J. NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties. The Journal of Clinical Investigation. 91: 1582-9. PMID 8473501 DOI: 10.1172/Jci116364  0.34
1993 Simon DI, Stamler JS, Jaraki O, Keaney JF, Osborne JA, Francis SA, Singel DJ, Loscalzo J. Antiplatelet properties of protein S-nitrosothiols derived from nitric oxide and endothelium-derived relaxing factor. Arteriosclerosis and Thrombosis : a Journal of Vascular Biology / American Heart Association. 13: 791-9. PMID 8388713 DOI: 10.1161/01.Atv.13.6.791  0.302
1993 Stamler JS, Osborne JA, Jaraki O, Rabbani LE, Mullins M, Singel D, Loscalzo J. Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. The Journal of Clinical Investigation. 91: 308-18. PMID 8380812 DOI: 10.1172/Jci116187  0.355
1993 Loscalzo J. The induction of cellular interactions in atherogenesis and their modulation Biochemical Society Transactions. 21: 656-659. PMID 8135929 DOI: 10.1042/Bst0210656  0.301
1992 Loscalzo J. Antiplatelet and antithrombotic effects of organic nitrates The American Journal of Cardiology. 70. PMID 1529922 DOI: 10.1016/0002-9149(92)90590-U  0.312
1992 Stamler JS, Jaraki O, Osborne J, Simon DI, Keaney J, Vita J, Singel D, Valeri CR, Loscalzo J. Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. Proceedings of the National Academy of Sciences of the United States of America. 89: 7674-7. PMID 1502182 DOI: 10.1073/Pnas.89.16.7674  0.344
1992 Stamler JS, Simon DI, Osborne JA, Mullins ME, Jaraki O, Michel T, Singel DJ, Loscalzo J. S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds. Proceedings of the National Academy of Sciences of the United States of America. 89: 444-8. PMID 1346070 DOI: 10.1073/Pnas.89.1.444  0.337
1992 Stamler JS, Loscalzo J. Endothelium-derived relaxing factor modulates the atherothrombogenic effects of homocysteine Journal of Cardiovascular Pharmacology. 20. PMID 1282970 DOI: 10.1097/00005344-199204002-00057  0.351
1992 Stamler JS, Singel DJ, Loscalzo J. Biochemistry of nitric oxide and its redox-activated forms Science. 258: 1898-1902. PMID 1281928 DOI: 10.1126/Science.1281928  0.317
1991 Rabbani LE, Loscalzo J. The effects of hyperlipidemia and atherosclerosis on endothelial function and vascular reactivity Current Opinion in Lipidology. 2: 259-265. DOI: 10.1097/00041433-199108000-00007  0.316
1989 Stamler JS, Vaughan DE, Loscalzo J. Synergistic disaggregation of platelets by tissue-type plasminogen activator, prostaglandin E1, and nitroglycerin Circulation Research. 65: 796-804. PMID 2504509 DOI: 10.1161/01.Res.65.3.796  0.314
1989 Schafer A, Rodriguez R, Loscalzo J, Gimbrone MJ. Inhibition of vascular endothelial cell prostacyclin synthesis by plasmin Blood. 74: 1015-1020. DOI: 10.1182/Blood.V74.3.1015.1015  0.317
1975 Loscalzo J, Reed GH, Weber A. Conformational change and cooperativity in actin filaments free of tropomyosin Proceedings of the National Academy of Sciences of the United States of America. 72: 3412-3415. PMID 1103145 DOI: 10.1073/Pnas.72.9.3412  0.59
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