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Albert J.R. Heck - Publications

Affiliations: 
Utrecht University, Utrecht, Netherlands 
Area:
mass spectrometry
Website:
http://bioms.chem.uu.nl/index.php/groupp-members/people/userprofile/heck

350 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Liu Z, Zhou Y, Liu J, Chen J, Heck AJ, Wang F. Reductive methylation labeling, from quantitative to structural proteomics Trac Trends in Analytical Chemistry. 118: 771-778. DOI: 10.1016/J.Trac.2019.07.009  0.326
2018 Lizatović R, Assent M, Barendregt A, Dahlin J, Bille A, Satzinger K, Tupina D, Heck AJ, Wennmalm S, André I. A protein encapsulation system with Ca2+-controlled cargo loading and detachment. Angewandte Chemie (International Ed. in English). PMID 29975817 DOI: 10.1002/Anie.201806466  0.318
2018 Reiding KR, Bondt A, Franc V, Heck AJ. The benefits of hybrid fragmentation methods for glycoproteomics Trac Trends in Analytical Chemistry. 108: 260-268. DOI: 10.1016/J.Trac.2018.09.007  0.381
2017 Wang G, de Jong RN, van den Bremer ET, Parren PW, Heck AJ. Enhancing accuracy in molecular weight determination of highly heterogeneously glycosylated proteins by native tandem mass spectrometry. Analytical Chemistry. PMID 28383250 DOI: 10.1021/Acs.Analchem.6B05129  0.414
2017 Snijder J, Radtke K, Anderson F, Scholtes L, Corradini E, Baines J, Heck AJ, Wuite GJ, Sodeik B, Roos WH. The vertex specific proteins pUL17 and pUL25 mechanically reinforce Herpes Simplex Virus capsids. Journal of Virology. PMID 28381566 DOI: 10.1128/Jvi.00123-17  0.326
2017 van Ooijen MP, Jong VL, Eijkemans MJ, Heck AJ, Andeweg AC, Binai NA, van den Ham HJ. Identification of differentially expressed peptides in high-throughput proteomics data. Briefings in Bioinformatics. PMID 28369175 DOI: 10.1093/Bib/Bbx031  0.355
2017 van de Waterbeemd M, Llauró A, Snijder J, Valbuena A, Rodríguez-Huete A, Fuertes MA, de Pablo PJ, Mateu MG, Heck AJ. Structural Analysis of a Temperature-Induced Transition in a Viral Capsid Probed by HDX-MS. Biophysical Journal. 112: 1157-1165. PMID 28355543 DOI: 10.1016/J.Bpj.2017.02.003  0.345
2017 Snijder J, Schuller JM, Wiegard A, Lössl P, Schmelling N, Axmann IM, Plitzko JM, Förster F, Heck AJ. Structures of the cyanobacterial circadian oscillator frozen in a fully assembled state. Science (New York, N.Y.). 355: 1181-1184. PMID 28302852 DOI: 10.1126/Science.Aag3218  0.358
2017 Yang Y, Wang G, Song T, Lebrilla CB, Heck AJ. Resolving the micro-heterogeneity and structural integrity of monoclonal antibodies by hybrid mass spectrometric approaches. Mabs. 1-8. PMID 28281873 DOI: 10.1080/19420862.2017.1290033  0.358
2017 Sasaki E, Böhringer D, van de Waterbeemd M, Leibundgut M, Zschoche R, Heck AJ, Ban N, Hilvert D. Structure and assembly of scalable porous protein cages. Nature Communications. 8: 14663. PMID 28281548 DOI: 10.1038/Ncomms14663  0.327
2017 Cristobal A, Marino F, Post H, van den Toorn HW, Mohammed S, Heck AJ. Towards an optimized workflow for middle-down proteomics. Analytical Chemistry. PMID 28233997 DOI: 10.1021/Acs.Analchem.6B03756  0.359
2017 Franc V, Yang Y, Heck AJ. Proteoform profile mapping of the human serum Complement component C9 reveals unexpected new features of N-, O- and C-glycosylation. Analytical Chemistry. PMID 28221766 DOI: 10.1021/Acs.Analchem.6B04527  0.373
2017 Lebesgue N, Megyeri M, Cristobal A, Scholten A, Chuartzman SG, Voichek Y, Scheltema RA, Mohammed S, Futerman AH, Schuldiner M, Heck AJ, Lemeer S. Combining Deep Sequencing, Proteomics, Phosphoproteomics, and Functional Screens To Discover Novel Regulators of Sphingolipid Homeostasis. Journal of Proteome Research. 16: 571-582. PMID 28152593 DOI: 10.1021/Acs.Jproteome.6B00691  0.313
2017 van de Waterbeemd M, Fort KL, Boll D, Reinhardt-Szyba M, Routh A, Makarov A, Heck AJ. High-fidelity mass analysis unveils heterogeneity in intact ribosomal particles. Nature Methods. PMID 28114288 DOI: 10.1038/Nmeth.4147  0.375
2017 Cristobal A, van den Toorn HW, van de Wetering M, Clevers H, Heck AJ, Mohammed S. Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer. Cell Reports. 18: 263-274. PMID 28052255 DOI: 10.1016/J.Celrep.2016.12.016  0.301
2016 Tsiatsiani L, Giansanti P, Scheltema RA, van den Toorn H, Overall CM, Altelaar AF, Heck AJ. Opposite Electron-Transfer Dissociation and Higher-Energy Collisional Dissociation Fragmentation Characteristics of Proteolytic K/R(X)n and (X)nK/R Peptides Provide Benefits for Peptide Sequencing in Proteomics and Phosphoproteomics. Journal of Proteome Research. PMID 28111955 DOI: 10.1021/Acs.Jproteome.6B00825  0.342
2016 Post H, Penning R, Fitzpatrick MA, Garrigues LB, Wu W, MacGillavry HD, Hoogenraad CC, Heck AJ, Altelaar AF. Robust, Sensitive, and Automated Phosphopeptide Enrichment Optimized for Low Sample Amounts Applied to Primary Hippocampal Neurons. Journal of Proteome Research. PMID 28107008 DOI: 10.1021/Acs.Jproteome.6B00753  0.341
2016 De Nardis C, Lössl P, van den Biggelaar M, Madoori PK, Leloup N, Mertens K, Heck AJ, Gros P. Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP). The Journal of Biological Chemistry. PMID 27956551 DOI: 10.1074/Jbc.M116.758862  0.34
2016 Alpízar A, Marino F, Ramos-Fernández A, Lombardía M, Jeko A, Pazos F, Paradela A, Santiago C, Heck AJ, Marcilla M. A molecular basis for the presentation of phosphorylated peptides by HLA-B antigens. Molecular & Cellular Proteomics : McP. PMID 27920218 DOI: 10.1074/Mcp.M116.063800  0.311
2016 Leney AC, Heck AJ. Native Mass Spectrometry: What is in the Name? Journal of the American Society For Mass Spectrometry. PMID 27909974 DOI: 10.1007/S13361-016-1545-3  0.37
2016 Loo JA, Heck AJ. Editorial and Review: 31(st) ASMS Asilomar Conference on Native Mass Spectrometry-Based Structural Biology. Journal of the American Society For Mass Spectrometry. PMID 27896696 DOI: 10.1007/S13361-016-1540-8  0.313
2016 Yang Y, Liu F, Franc V, Halim LA, Schellekens H, Heck AJ. Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity. Nature Communications. 7: 13397. PMID 27824045 DOI: 10.1038/Ncomms13397  0.408
2016 Lössl P, van de Waterbeemd M, Heck AJ. The diverse and expanding role of mass spectrometry in structural and molecular biology. The Embo Journal. 35: 2634-2657. PMID 27797822 DOI: 10.15252/Embj.201694818  0.363
2016 Chiang DY, Heck AJ, Dobrev D, Wehrens XH. Regulating the regulator: Insights into the cardiac protein phosphatase 1 interactome. Journal of Molecular and Cellular Cardiology. PMID 27663175 DOI: 10.1016/J.Yjmcc.2016.09.009  0.367
2016 Liu Q, Liu F, Yu KL, Tas R, Grigoriev I, Remmelzwaal S, Serra-Marques A, Kapitein LC, Heck AJ, Akhmanova A. MICAL3 flavoprotein monooxygenase forms a complex with centralspindlin and regulates cytokinesis. The Journal of Biological Chemistry. PMID 27528609 DOI: 10.1074/Jbc.M116.748186  0.35
2016 Waaijers S, Muñoz J, Berends C, Ramalho JJ, Goerdayal SS, Low TY, Zoumaro-Djayoon AD, Hoffmann M, Koorman T, Tas RP, Harterink M, Seelk S, Kerver J, Hoogenraad CC, Bossinger O, ... ... Heck AJ, et al. A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large. Bmc Biology. 14: 66. PMID 27506200 DOI: 10.1186/S12915-016-0286-X  0.381
2016 Lössl P, Brunner AM, Liu F, Leney AC, Yamashita M, Scheltema RA, Heck AJ. Deciphering the Interplay among Multisite Phosphorylation, Interaction Dynamics, and Conformational Transitions in a Tripartite Protein System. Acs Central Science. 2: 445-55. PMID 27504491 DOI: 10.1021/Acscentsci.6B00053  0.382
2016 Tamara S, Dyachenko A, Fort KL, Makarov AA, Scheltema RA, Heck AJ. Symmetry of Charge Partitioning in Collisional and UV Photon-induced Dissociation of Protein Assemblies. Journal of the American Chemical Society. PMID 27480281 DOI: 10.1021/Jacs.6B05147  0.394
2016 Snijder J, Kononova O, Barbu IM, Uetrecht C, Rurup WF, Burnley RJ, Koay MS, Cornelissen JJ, Roos WH, Barsegov V, Wuite GJ, Heck AJ. Assembly and mechanical properties of the cargo-free and cargo-loaded bacterial nanocompartment encapsulin. Biomacromolecules. PMID 27355101 DOI: 10.1021/Acs.Biomac.6B00469  0.322
2016 Wang G, de Jong RN, van den Bremer ET, Beurskens FJ, Labrijn AF, Ugurlar D, Gros P, Schuurman J, Parren PW, Heck AJ. Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen. Molecular Cell. PMID 27320199 DOI: 10.1016/J.Molcel.2016.05.016  0.316
2016 Schmidlin T, Garrigues L, Lane CS, Mulder TC, van Doorn S, Post H, de Graaf EL, Lemeer S, Heck AJ, Altelaar AF. Assessment of SRM, MRM(3) and DIA for the targeted analysis of phosphorylation dynamics in non-small cell lung cancer. Proteomics. PMID 27219855 DOI: 10.1002/Pmic.201500453  0.343
2016 Lebesgue N, da Costa G, Ribeiro RM, Ribeiro-Silva C, Martins GG, Matranga V, Scholten A, Cordeiro C, Heck AJ, Santos R. Proteomic dataset of the sea urchin Paracentrotus lividus adhesive organs and secreted adhesive. Data in Brief. 7: 1497-505. PMID 27182547 DOI: 10.1016/J.Dib.2016.04.002  0.362
2016 Soni S, Raaijmakers AJ, Raaijmakers LM, Damen JM, van Stuijvenberg L, Vos MA, Heck AJ, van Veen TA, Scholten A. A Proteomics Approach to Identify New Putative Cardiac Intercalated Disk Proteins. Plos One. 11: e0152231. PMID 27148881 DOI: 10.1371/Journal.Pone.0152231  0.309
2016 Guerreiro AC, Penning R, Raaijmakers LM, Axman IM, Heck AJ, Altelaar AF. Monitoring light/dark association dynamics of multi-protein complexes in cyanobacteria using size exclusion chromatography-based proteomics. Journal of Proteomics. PMID 27142972 DOI: 10.1016/J.Jprot.2016.04.030  0.332
2016 Giansanti P, Tsiatsiani L, Low TY, Heck AJ. Six alternative proteases for mass spectrometry-based proteomics beyond trypsin. Nature Protocols. 11: 993-1006. PMID 27123950 DOI: 10.1038/Nprot.2016.057  0.409
2016 Burgers PP, Bruystens J, Burnley RJ, Nikolaev VO, Keshwani M, Wu J, Janssen BJ, Taylor SS, Heck AJ, Scholten A. Structure of smAKAP and its regulation by PKA-mediated phosphorylation. The Febs Journal. PMID 27028580 DOI: 10.1111/Febs.13726  0.309
2016 van de Waterbeemd M, Snijder J, Tsvetkova IB, Dragnea BG, Cornelissen JJ, Heck AJ. Examining the Heterogeneous Genome Content of Multipartite Viruses BMV and CCMV by Native Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 26926442 DOI: 10.1007/S13361-016-1348-6  0.377
2016 Lebesgue N, da Costa G, Ribeiro RM, Ribeiro-Silva C, Martins GG, Matranga V, Scholten A, Cordeiro C, Heck AJ, Santos R. Deciphering the molecular mechanisms underlying sea urchin reversible adhesion: A quantitative proteomics approach. Journal of Proteomics. PMID 26926440 DOI: 10.1016/J.Jprot.2016.02.026  0.328
2016 Mommen GP, Marino F, Meiring HD, Poelen MC, van Gaans-van den Brink JA, Mohammed S, Heck AJ, van Els CA. Sampling from the proteome to the HLA-DR ligandome proceeds via high specificity. Molecular & Cellular Proteomics : McP. PMID 26764012 DOI: 10.1074/Mcp.M115.055780  0.316
2016 Fort KL, Dyachenko A, Potel CM, Corradini E, Marino F, Barendregt A, Makarov AA, Scheltema RA, Heck AJ. Implementation of UV-photodissociation on a benchtop Q Exactive mass spectrometer and its application to phospho-proteomics. Analytical Chemistry. PMID 26760441 DOI: 10.1021/Acs.Analchem.5B04162  0.356
2015 Liu F, Heck AJ. Interrogating the architecture of protein assemblies and protein interaction networks by cross-linking mass spectrometry. Current Opinion in Structural Biology. 35: 100-108. PMID 26615471 DOI: 10.1016/J.Sbi.2015.10.006  0.391
2015 Low TY, Heck AJ. Reconciling proteomics with next generation sequencing. Current Opinion in Chemical Biology. 30: 14-20. PMID 26590485 DOI: 10.1016/J.Cbpa.2015.10.023  0.301
2015 Liu F, Rijkers DT, Post H, Heck AJ. Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry. Nature Methods. PMID 26414014 DOI: 10.1038/Nmeth.3603  0.372
2015 Schmidlin T, Boender AJ, Frese CK, Heck AJ, Adan RA, Altelaar AF. Diet-Induced Neuropeptide Expression: Feasibility of Quantifying Extended and Highly Charged Endogenous Peptide Sequences by Selected Reaction Monitoring. Analytical Chemistry. PMID 26376940 DOI: 10.1021/Acs.Analchem.5B03334  0.32
2015 Zeqiraj E, Tian L, Piggott CA, Pillon MC, Duffy NM, Ceccarelli DF, Keszei AF, Lorenzen K, Kurinov I, Orlicky S, Gish GD, Heck AJ, Guarné A, Greenberg RA, Sicheri F. Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function. Molecular Cell. 59: 970-83. PMID 26344097 DOI: 10.1016/J.Molcel.2015.07.028  0.328
2015 Raaijmakers LM, Giansanti P, Possik PA, Mueller J, Peeper DS, Heck AJ, Altelaar AF. PhosphoPath: Visualization of Phosphosite-centric Dynamics in Temporal Molecular Networks. Journal of Proteome Research. PMID 26317507 DOI: 10.1021/Acs.Jproteome.5B00529  0.306
2015 Magliozzi R, Peng M, Mohammed S, Guardavaccaro D, Heck AJ, Low TY. Datasets from an interaction proteomics screen for substrates of the SCF(βTrCP) ubiquitin ligase. Data in Brief. 4: 229-34. PMID 26217795 DOI: 10.1016/J.Dib.2015.05.003  0.367
2015 Corradini E, Klaasse G, Leurs U, Heck AJ, Martin NI, Scholten A. Charting the interactome of PDE3A in human cells using an IBMX based chemical proteomics approach. Molecular Biosystems. PMID 26205238 DOI: 10.1039/C5Mb00142K  0.386
2015 Heck AJ. Gaining weight in structural biology: Applications of mass spectrometry in protein science. Protein Science : a Publication of the Protein Society. 24: 1173-5. PMID 26183567 DOI: 10.1002/Pro.2725  0.41
2015 Glas M, van den Berg van Saparoea HB, McLaughlin SH, Roseboom W, Liu F, Koningstein GM, Fish A, den Blaauwen T, Heck AJ, de Jong L, Bitter W, de Esch IJ, Luirink J. The Soluble Periplasmic Domains of Escherichia coli Cell Division Proteins FtsQ/FtsB/FtsL Form a Trimeric Complex with Submicromolar Affinity. The Journal of Biological Chemistry. 290: 21498-509. PMID 26160297 DOI: 10.1074/Jbc.M115.654756  0.386
2015 Giansanti P, Aye TT, van den Toorn H, Peng M, van Breukelen B, Heck AJ. An Augmented Multiple-Protease-Based Human Phosphopeptide Atlas. Cell Reports. 11: 1834-43. PMID 26074081 DOI: 10.1016/J.Celrep.2015.05.029  0.385
2015 Peng M, Aye TT, Snel B, van Breukelen B, Scholten A, Heck AJ. Spatial Organization in Protein Kinase A Signaling Emerged at the Base of Animal Evolution. Journal of Proteome Research. PMID 26066639 DOI: 10.1021/Acs.Jproteome.5B00370  0.314
2015 Dyachenko A, Wang G, Belov M, Makarov A, de Jong RN, van den Bremer ET, Parren PW, Heck AJ. Tandem Native Mass-Spectrometry on Antibody-Drug Conjugates and Submillion Da Antibody-Antigen Protein Assemblies on an Orbitrap EMR Equipped with a High-Mass Quadrupole Mass Selector. Analytical Chemistry. 87: 6095-102. PMID 25978613 DOI: 10.1021/Acs.Analchem.5B00788  0.353
2015 Tsiatsiani L, Heck AJ. Proteomics beyond trypsin. The Febs Journal. PMID 25823410 DOI: 10.1111/Febs.13287  0.408
2015 Brunner AM, Lössl P, Liu F, Huguet R, Mullen C, Yamashita M, Zabrouskov V, Makarov A, Altelaar AF, Heck AJ. Benchmarking multiple fragmentation methods on an orbitrap fusion for top-down phospho-proteoform characterization. Analytical Chemistry. 87: 4152-8. PMID 25803405 DOI: 10.1021/Acs.Analchem.5B00162  0.41
2015 Corradini E, Heck AJ, Scholten A. Separation of PKA and PKG signaling nodes by chemical proteomics. Methods in Molecular Biology (Clifton, N.J.). 1294: 191-201. PMID 25783887 DOI: 10.1007/978-1-4939-2537-7_15  0.377
2015 Vogel CJ, Smit MA, Maddalo G, Possik PA, Sparidans RW, van der Burg SH, Verdegaal EM, Heck AJ, Samatar AA, Beijnen JH, Altelaar AF, Peeper DS. Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK. Pigment Cell & Melanoma Research. 28: 307-17. PMID 25728708 DOI: 10.1111/Pcmr.12364  0.68
2015 Corradini E, Burgers PP, Plank M, Heck AJ, Scholten A. Huntingtin-associated protein 1 (HAP1) is a cGMP-dependent kinase anchoring protein (GKAP) specific for the cGMP-dependent protein kinase Iβ isoform. The Journal of Biological Chemistry. 290: 7887-96. PMID 25653285 DOI: 10.1074/Jbc.M114.622613  0.387
2015 Gautier V, Boumeester AJ, Lössl P, Heck AJ. Lysine conjugation properties in human IgGs studied by integrating high-resolution native mass spectrometry and bottom-up proteomics. Proteomics. PMID 25641908 DOI: 10.1002/Pmic.201400462  0.352
2015 Binai NA, Marino F, Soendergaard P, Bache N, Mohammed S, Heck AJ. Rapid analyses of proteomes and interactomes using an integrated solid-phase extraction-liquid chromatography-MS/MS system. Journal of Proteome Research. 14: 977-85. PMID 25485597 DOI: 10.1021/Pr501011Z  0.346
2015 Götzke H, Muheim C, Altelaar AF, Heck AJ, Maddalo G, Daley DO. Identification of putative substrates for the periplasmic chaperone YfgM in Escherichia coli using quantitative proteomics. Molecular & Cellular Proteomics : McP. 14: 216-26. PMID 25403562 DOI: 10.1074/Mcp.M114.043216  0.731
2015 Burgers PP, van der Heyden MA, Kok B, Heck AJ, Scholten A. A systematic evaluation of protein kinase A-A-kinase anchoring protein interaction motifs. Biochemistry. 54: 11-21. PMID 25097019 DOI: 10.1021/Bi500721A  0.362
2014 Smit MA, Maddalo G, Greig K, Raaijmakers LM, Possik PA, van Breukelen B, Cappadona S, Heck AJ, Altelaar AF, Peeper DS. ROCK1 is a potential combinatorial drug target for BRAF mutant melanoma. Molecular Systems Biology. 10: 772. PMID 25538140 DOI: 10.15252/Msb.20145450  0.702
2014 Castaño-Cerezo S, Bernal V, Post H, Fuhrer T, Cappadona S, Sánchez-Díaz NC, Sauer U, Heck AJ, Altelaar AF, Cánovas M. Protein acetylation affects acetate metabolism, motility and acid stress response in Escherichia coli. Molecular Systems Biology. 10: 762. PMID 25518064 DOI: 10.15252/Msb.20145227  0.355
2014 Low TY, Peng M, Magliozzi R, Mohammed S, Guardavaccaro D, Heck AJ. A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase. Science Signaling. 7: rs8. PMID 25515538 DOI: 10.1126/Scisignal.2005882  0.361
2014 Benevento M, Tonge PD, Puri MC, Hussein SM, Cloonan N, Wood DL, Grimmond SM, Nagy A, Munoz J, Heck AJ. Proteome adaptation in cell reprogramming proceeds via distinct transcriptional networks. Nature Communications. 5: 5613. PMID 25494451 DOI: 10.1038/Ncomms6613  0.328
2014 Marino F, Cristobal A, Binai NA, Bache N, Heck AJ, Mohammed S. Characterization and usage of the EASY-spray technology as part of an online 2D SCX-RP ultra-high pressure system. The Analyst. 139: 6520-8. PMID 25346955 DOI: 10.1039/C4An01568A  0.347
2014 Magliozzi R, Kim J, Low TY, Heck AJ, Guardavaccaro D. Degradation of Tiam1 by casein kinase 1 and the SCFβTrCP ubiquitin ligase controls the duration of mTOR-S6K signaling. The Journal of Biological Chemistry. 289: 27400-9. PMID 25124033 DOI: 10.1074/Jbc.M114.575571  0.302
2014 Muñoz J, Heck AJ. From the human genome to the human proteome. Angewandte Chemie (International Ed. in English). 53: 10864-6. PMID 25079383 DOI: 10.1002/Anie.201406545  0.384
2014 Matheron L, van den Toorn H, Heck AJ, Mohammed S. Characterization of biases in phosphopeptide enrichment by Ti(4+)-immobilized metal affinity chromatography and TiO2 using a massive synthetic library and human cell digests. Analytical Chemistry. 86: 8312-20. PMID 25068997 DOI: 10.1021/Ac501803Z  0.327
2014 van de Waterbeemd M, Lössl P, Gautier V, Marino F, Yamashita M, Conti E, Scholten A, Heck AJ. Simultaneous assessment of kinetic, site-specific, and structural aspects of enzymatic protein phosphorylation. Angewandte Chemie (International Ed. in English). 53: 9660-4. PMID 25044833 DOI: 10.1002/Anie.201404637  0.414
2014 Snijder J, Heck AJ. Analytical approaches for size and mass analysis of large protein assemblies. Annual Review of Analytical Chemistry (Palo Alto, Calif.). 7: 43-64. PMID 25014341 DOI: 10.1146/Annurev-Anchem-071213-020015  0.371
2014 Binai NA, Bisschops MM, van Breukelen B, Mohammed S, Loeff L, Pronk JT, Heck AJ, Daran-Lapujade P, Slijper M. Proteome adaptation of Saccharomyces cerevisiae to severe calorie restriction in Retentostat cultures. Journal of Proteome Research. 13: 3542-53. PMID 25000127 DOI: 10.1021/Pr5003388  0.302
2014 Pinkse MW, Heck AJ. Essential enrichment strategies in phosphoproteomics. Drug Discovery Today. Technologies. 3: 331-7. PMID 24980537 DOI: 10.1016/J.Ddtec.2006.09.009  0.349
2014 Gavin AC, Heck A. Expanding the frontiers in proteomics. Drug Discovery Today. Technologies. 3: 315-6. PMID 24980534 DOI: 10.1016/J.Ddtec.2006.09.016  0.329
2014 Liu F, van Breukelen B, Heck AJ. Facilitating protein disulfide mapping by a combination of pepsin digestion, electron transfer higher energy dissociation (EThcD), and a dedicated search algorithm SlinkS. Molecular & Cellular Proteomics : McP. 13: 2776-86. PMID 24980484 DOI: 10.1074/Mcp.O114.039057  0.386
2014 van Duijn E, Heck AJ. Mass spectrometric analysis of intact macromolecular chaperone complexes. Drug Discovery Today. Technologies. 3: 21-7. PMID 24980098 DOI: 10.1016/J.Ddtec.2006.03.008  0.388
2014 Kleppe R, Rosati S, Jorge-Finnigan A, Alvira S, Ghorbani S, Haavik J, Valpuesta JM, Heck AJ, Martinez A. Phosphorylation dependence and stoichiometry of the complex formed by tyrosine hydroxylase and 14-3-3γ. Molecular & Cellular Proteomics : McP. 13: 2017-30. PMID 24947669 DOI: 10.1074/Mcp.M113.035709  0.308
2014 Corradini E, Vallur R, Raaijmakers LM, Feil S, Feil R, Heck AJ, Scholten A. Alterations in the cerebellar (Phospho)proteome of a cyclic guanosine monophosphate (cGMP)-dependent protein kinase knockout mouse. Molecular & Cellular Proteomics : McP. 13: 2004-16. PMID 24925903 DOI: 10.1074/Mcp.M113.035154  0.364
2014 Kelstrup CD, Frese C, Heck AJ, Olsen JV, Nielsen ML. Analytical utility of mass spectral binning in proteomic experiments by SPectral Immonium Ion Detection (SPIID). Molecular & Cellular Proteomics : McP. 13: 1914-24. PMID 24895383 DOI: 10.1074/Mcp.O113.035915  0.375
2014 de Graaf EL, Giansanti P, Altelaar AF, Heck AJ. Single-step enrichment by Ti4+-IMAC and label-free quantitation enables in-depth monitoring of phosphorylation dynamics with high reproducibility and temporal resolution. Molecular & Cellular Proteomics : McP. 13: 2426-34. PMID 24850871 DOI: 10.1074/Mcp.O113.036608  0.315
2014 Giansanti P, Preisinger C, Huber KV, Gridling M, Superti-Furga G, Bennett KL, Heck AJ. Evaluating the promiscuous nature of tyrosine kinase inhibitors assessed in A431 epidermoid carcinoma cells by both chemical- and phosphoproteomics. Acs Chemical Biology. 9: 1490-8. PMID 24804581 DOI: 10.1021/Cb500116C  0.318
2014 Snijder J, van de Waterbeemd M, Damoc E, Denisov E, Grinfeld D, Bennett A, Agbandje-McKenna M, Makarov A, Heck AJ. Defining the stoichiometry and cargo load of viral and bacterial nanoparticles by Orbitrap mass spectrometry. Journal of the American Chemical Society. 136: 7295-9. PMID 24787140 DOI: 10.1021/Ja502616Y  0.329
2014 Bereszczak JZ, Watts NR, Wingfield PT, Steven AC, Heck AJ. Assessment of differences in the conformational flexibility of hepatitis B virus core-antigen and e-antigen by hydrogen deuterium exchange-mass spectrometry. Protein Science : a Publication of the Protein Society. 23: 884-96. PMID 24715628 DOI: 10.1002/Pro.2470  0.344
2014 Lössl P, Snijder J, Heck AJ. Boundaries of mass resolution in native mass spectrometry. Journal of the American Society For Mass Spectrometry. 25: 906-17. PMID 24700121 DOI: 10.1007/S13361-014-0874-3  0.375
2014 Guerreiro AC, Benevento M, Lehmann R, van Breukelen B, Post H, Giansanti P, Maarten Altelaar AF, Axmann IM, Heck AJ. Daily rhythms in the cyanobacterium synechococcus elongatus probed by high-resolution mass spectrometry-based proteomics reveals a small defined set of cyclic proteins. Molecular & Cellular Proteomics : McP. 13: 2042-55. PMID 24677030 DOI: 10.1074/Mcp.M113.035840  0.357
2014 Rosati S, Yang Y, Barendregt A, Heck AJ. Detailed mass analysis of structural heterogeneity in monoclonal antibodies using native mass spectrometry. Nature Protocols. 9: 967-76. PMID 24675736 DOI: 10.1038/Nprot.2014.057  0.393
2014 Snijder J, Benevento M, Moyer CL, Reddy V, Nemerow GR, Heck AJ. The cleaved N-terminus of pVI binds peripentonal hexons in mature adenovirus. Journal of Molecular Biology. 426: 1971-9. PMID 24613303 DOI: 10.1016/J.Jmb.2014.02.022  0.401
2014 Benevento M, Di Palma S, Snijder J, Moyer CL, Reddy VS, Nemerow GR, Heck AJ. Adenovirus composition, proteolysis, and disassembly studied by in-depth qualitative and quantitative proteomics. The Journal of Biological Chemistry. 289: 11421-30. PMID 24591515 DOI: 10.1074/Jbc.M113.537498  0.381
2014 Rurup WF, Snijder J, Koay MS, Heck AJ, Cornelissen JJ. Self-sorting of foreign proteins in a bacterial nanocompartment. Journal of the American Chemical Society. 136: 3828-32. PMID 24527660 DOI: 10.1021/Ja410891C  0.312
2014 D'Annibale S, Kim J, Magliozzi R, Low TY, Mohammed S, Heck AJ, Guardavaccaro D. Proteasome-dependent degradation of transcription factor activating enhancer-binding protein 4 (TFAP4) controls mitotic division. The Journal of Biological Chemistry. 289: 7730-7. PMID 24500709 DOI: 10.1074/Jbc.M114.549535  0.306
2014 Snijder J, Burnley RJ, Wiegard A, Melquiond AS, Bonvin AM, Axmann IM, Heck AJ. Insight into cyanobacterial circadian timing from structural details of the KaiB-KaiC interaction. Proceedings of the National Academy of Sciences of the United States of America. 111: 1379-84. PMID 24474762 DOI: 10.1073/Pnas.1314326111  0.331
2014 Thompson NJ, Merdanovic M, Ehrmann M, van Duijn E, Heck AJ. Substrate occupancy at the onset of oligomeric transitions of DegP. Structure (London, England : 1993). 22: 281-90. PMID 24373769 DOI: 10.1016/J.Str.2013.11.010  0.302
2014 Veesler D, Khayat R, Krishnamurthy S, Snijder J, Huang RK, Heck AJ, Anand GS, Johnson JE. Architecture of a dsDNA viral capsid in complex with its maturation protease. Structure (London, England : 1993). 22: 230-7. PMID 24361271 DOI: 10.1016/J.Str.2013.11.007  0.318
2014 Bereszczak JZ, Havlik M, Weiss VU, Marchetti-Deschmann M, van Duijn E, Watts NR, Wingfield PT, Allmaier G, Steven AC, Heck AJ. Sizing up large protein complexes by electrospray ionisation-based electrophoretic mobility and native mass spectrometry: morphology selective binding of Fabs to hepatitis B virus capsids. Analytical and Bioanalytical Chemistry. 406: 1437-46. PMID 24357008 DOI: 10.1007/S00216-013-7548-Z  0.326
2014 Thompson NJ, Hendriks LJ, de Kruif J, Throsby M, Heck AJ. Complex mixtures of antibodies generated from a single production qualitatively and quantitatively evaluated by native Orbitrap mass spectrometry. Mabs. 6: 197-203. PMID 24351421 DOI: 10.4161/Mabs.27126  0.326
2014 Peng M, Scholten A, Heck AJ, van Breukelen B. Identification of enriched PTM crosstalk motifs from large-scale experimental data sets. Journal of Proteome Research. 13: 249-59. PMID 24087892 DOI: 10.1021/Pr4005579  0.368
2014 Thompson NJ, Rosati S, Heck AJ. Performing native mass spectrometry analysis on therapeutic antibodies. Methods (San Diego, Calif.). 65: 11-7. PMID 23688935 DOI: 10.1016/J.Ymeth.2013.05.003  0.377
2013 Low TY, van Heesch S, van den Toorn H, Giansanti P, Cristobal A, Toonen P, Schafer S, Hübner N, van Breukelen B, Mohammed S, Cuppen E, Heck AJ, Guryev V. Quantitative and qualitative proteome characteristics extracted from in-depth integrated genomics and proteomics analysis. Cell Reports. 5: 1469-78. PMID 24290761 DOI: 10.1016/J.Celrep.2013.10.041  0.314
2013 Yang Y, Barendregt A, Kamerling JP, Heck AJ. Analyzing protein micro-heterogeneity in chicken ovalbumin by high-resolution native mass spectrometry exposes qualitatively and semi-quantitatively 59 proteoforms. Analytical Chemistry. 85: 12037-45. PMID 24229052 DOI: 10.1021/Ac403057Y  0.418
2013 Tseng YH, Uetrecht C, Yang SC, Barendregt A, Heck AJ, Peng WP. Game-theory-based search engine to automate the mass assignment in complex native electrospray mass spectra. Analytical Chemistry. 85: 11275-83. PMID 24171642 DOI: 10.1021/Ac401940E  0.36
2013 Rosati S, van den Bremer ET, Schuurman J, Parren PW, Kamerling JP, Heck AJ. In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution native mass spectrometry using a modified Orbitrap. Mabs. 5: 917-24. PMID 23995615 DOI: 10.4161/Mabs.26282  0.325
2013 Scholten A, Preisinger C, Corradini E, Bourgonje VJ, Hennrich ML, van Veen TA, Swaminathan PD, Joiner ML, Vos MA, Anderson ME, Heck AJ. Phosphoproteomics study based on in vivo inhibition reveals sites of calmodulin-dependent protein kinase II regulation in the heart. Journal of the American Heart Association. 2: e000318. PMID 23926118 DOI: 10.1161/Jaha.113.000318  0.365
2013 Mellacheruvu D, Wright Z, Couzens AL, Lambert JP, St-Denis NA, Li T, Miteva YV, Hauri S, Sardiu ME, Low TY, Halim VA, Bagshaw RD, Hubner NC, Al-Hakim A, Bouchard A, ... ... Heck AJ, et al. The CRAPome: a contaminant repository for affinity purification-mass spectrometry data. Nature Methods. 10: 730-6. PMID 23921808 DOI: 10.1038/Nmeth.2557  0.393
2013 Di Palma S, Zoumaro-Djayoon A, Peng M, Post H, Preisinger C, Munoz J, Heck AJ. Finding the same needles in the haystack? A comparison of phosphotyrosine peptides enriched by immuno-affinity precipitation and metal-based affinity chromatography. Journal of Proteomics. 91: 331-7. PMID 23917254 DOI: 10.1016/J.Jprot.2013.07.024  0.358
2013 Giansanti P, Stokes MP, Silva JC, Scholten A, Heck AJ. Interrogating cAMP-dependent kinase signaling in Jurkat T cells via a protein kinase A targeted immune-precipitation phosphoproteomics approach. Molecular & Cellular Proteomics : McP. 12: 3350-9. PMID 23882029 DOI: 10.1074/Mcp.O113.028456  0.362
2013 Mommen GP, Meiring HD, Heck AJ, de Jong AP. Mixed-bed ion exchange chromatography employing a salt-free pH gradient for improved sensitivity and compatibility in MudPIT. Analytical Chemistry. 85: 6608-16. PMID 23772827 DOI: 10.1021/Ac400995E  0.347
2013 Berends CW, Muñoz J, Portegijs V, Schmidt R, Grigoriev I, Boxem M, Akhmanova A, Heck AJ, van den Heuvel S. F-actin asymmetry and the endoplasmic reticulum-associated TCC-1 protein contribute to stereotypic spindle movements in the Caenorhabditis elegans embryo. Molecular Biology of the Cell. 24: 2201-15. PMID 23699393 DOI: 10.1091/Mbc.E13-02-0076  0.307
2013 Marx H, Lemeer S, Schliep JE, Matheron L, Mohammed S, Cox J, Mann M, Heck AJ, Kuster B. A large synthetic peptide and phosphopeptide reference library for mass spectrometry-based proteomics. Nature Biotechnology. 31: 557-64. PMID 23685481 DOI: 10.1038/Nbt.2585  0.344
2013 Esposito G, Garvey M, Alverdi V, Pettirossi F, Corazza A, Fogolari F, Polano M, Mangione PP, Giorgetti S, Stoppini M, Rekas A, Bellotti V, Heck AJ, Carver JA. Monitoring the interaction between β2-microglobulin and the molecular chaperone αB-crystallin by NMR and mass spectrometry: αB-crystallin dissociates β2-microglobulin oligomers. The Journal of Biological Chemistry. 288: 17844-58. PMID 23645685 DOI: 10.1074/Jbc.M112.448639  0.325
2013 Bleijerveld OB, van Holten TC, Preisinger C, van der Smagt JJ, Farndale RW, Kleefstra T, Willemsen MH, Urbanus RT, de Groot PG, Heck AJ, Roest M, Scholten A. Targeted phosphotyrosine profiling of glycoprotein VI signaling implicates oligophrenin-1 in platelet filopodia formation. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 1538-43. PMID 23619296 DOI: 10.1161/Atvbaha.112.300916  0.303
2013 Halim VA, Alvarez-Fernández M, Xu YJ, Aprelia M, van den Toorn HW, Heck AJ, Mohammed S, Medema RH. Comparative phosphoproteomic analysis of checkpoint recovery identifies new regulators of the DNA damage response. Science Signaling. 6: rs9. PMID 23612710 DOI: 10.1126/Scisignal.2003664  0.307
2013 Scholten A, Heck AJ. Determining protein concentrations of the human ventricular proteome. Methods in Molecular Biology (Clifton, N.J.). 1005: 11-24. PMID 23606245 DOI: 10.1007/978-1-62703-386-2_2  0.373
2013 Bereszczak JZ, Rose RJ, van Duijn E, Watts NR, Wingfield PT, Steven AC, Heck AJ. Epitope-distal effects accompany the binding of two distinct antibodies to hepatitis B virus capsids. Journal of the American Chemical Society. 135: 6504-12. PMID 23597076 DOI: 10.1021/Ja402023X  0.311
2013 Krijgsheld P, Nitsche BM, Post H, Levin AM, Müller WH, Heck AJ, Ram AF, Altelaar AF, Wösten HA. Deletion of flbA results in increased secretome complexity and reduced secretion heterogeneity in colonies of Aspergillus niger. Journal of Proteome Research. 12: 1808-19. PMID 23461488 DOI: 10.1021/Pr301154W  0.336
2013 Snijder J, Rose RJ, Veesler D, Johnson JE, Heck AJ. Studying 18 MDa virus assemblies with native mass spectrometry. Angewandte Chemie (International Ed. in English). 52: 4020-3. PMID 23450509 DOI: 10.1002/Anie.201210197  0.405
2013 Meijer LA, Zhou H, Chan OY, Altelaar AF, Hennrich ML, Mohammed S, Bos JL, Heck AJ. Quantitative global phosphoproteomics of human umbilical vein endothelial cells after activation of the Rap signaling pathway. Molecular Biosystems. 9: 732-49. PMID 23403867 DOI: 10.1039/C3Mb25524G  0.349
2013 Zhou H, Ye M, Dong J, Corradini E, Cristobal A, Heck AJ, Zou H, Mohammed S. Robust phosphoproteome enrichment using monodisperse microsphere-based immobilized titanium (IV) ion affinity chromatography. Nature Protocols. 8: 461-80. PMID 23391890 DOI: 10.1038/Nprot.2013.010  0.382
2013 Frese CK, Zhou H, Taus T, Altelaar AF, Mechtler K, Heck AJ, Mohammed S. Unambiguous phosphosite localization using electron-transfer/higher-energy collision dissociation (EThcD). Journal of Proteome Research. 12: 1520-5. PMID 23347405 DOI: 10.1021/Pr301130K  0.338
2013 Altelaar AF, Munoz J, Heck AJ. Next-generation proteomics: towards an integrative view of proteome dynamics. Nature Reviews. Genetics. 14: 35-48. PMID 23207911 DOI: 10.1038/Nrg3356  0.384
2013 Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S. Toward a comprehensive characterization of a human cancer cell phosphoproteome. Journal of Proteome Research. 12: 260-71. PMID 23186163 DOI: 10.1021/Pr300630K  0.327
2013 Thompson NJ, Rosati S, Rose RJ, Heck AJ. The impact of mass spectrometry on the study of intact antibodies: from post-translational modifications to structural analysis. Chemical Communications (Cambridge, England). 49: 538-48. PMID 23183499 DOI: 10.1039/C2Cc36755F  0.369
2012 Burgers PP, Ma Y, Margarucci L, Mackey M, van der Heyden MA, Ellisman M, Scholten A, Taylor SS, Heck AJ. A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane. The Journal of Biological Chemistry. 287: 43789-97. PMID 23115245 DOI: 10.1074/Jbc.M112.395970  0.351
2012 Nenci S, Piano V, Rosati S, Aliverti A, Pandini V, Fraaije MW, Heck AJ, Edmondson DE, Mattevi A. Precursor of ether phospholipids is synthesized by a flavoenzyme through covalent catalysis. Proceedings of the National Academy of Sciences of the United States of America. 109: 18791-6. PMID 23112191 DOI: 10.1073/Pnas.1215128109  0.308
2012 Frese CK, Altelaar AF, van den Toorn H, Nolting D, Griep-Raming J, Heck AJ, Mohammed S. Toward full peptide sequence coverage by dual fragmentation combining electron-transfer and higher-energy collision dissociation tandem mass spectrometry. Analytical Chemistry. 84: 9668-73. PMID 23106539 DOI: 10.1021/Ac3025366  0.338
2012 Di Palma S, Mohammed S, Heck AJ. ZIC-cHILIC as a fractionation method for sensitive and powerful shotgun proteomics. Nature Protocols. 7: 2041-55. PMID 23099486 DOI: 10.1038/Nprot.2012.124  0.343
2012 Rose RJ, Damoc E, Denisov E, Makarov A, Heck AJ. High-sensitivity Orbitrap mass analysis of intact macromolecular assemblies. Nature Methods. 9: 1084-6. PMID 23064518 DOI: 10.1038/Nmeth.2208  0.381
2012 Bleijerveld OB, Wijten P, Cappadona S, McClellan EA, Polat AN, Raijmakers R, Sels JW, Colle L, Grasso S, van den Toorn HW, van Breukelen B, Stubbs A, Pasterkamp G, Heck AJ, Hoefer IE, et al. Deep proteome profiling of circulating granulocytes reveals bactericidal/permeability-increasing protein as a biomarker for severe atherosclerotic coronary stenosis. Journal of Proteome Research. 11: 5235-44. PMID 23020738 DOI: 10.1021/Pr3004375  0.327
2012 Glatter T, Ludwig C, Ahrné E, Aebersold R, Heck AJ, Schmidt A. Large-scale quantitative assessment of different in-solution protein digestion protocols reveals superior cleavage efficiency of tandem Lys-C/trypsin proteolysis over trypsin digestion. Journal of Proteome Research. 11: 5145-56. PMID 23017020 DOI: 10.1021/Pr300273G  0.391
2012 Polat AN, Kraiczek K, Heck AJ, Raijmakers R, Mohammed S. Fully automated isotopic dimethyl labeling and phosphopeptide enrichment using a microfluidic HPLC phosphochip. Analytical and Bioanalytical Chemistry. 404: 2507-12. PMID 22975804 DOI: 10.1007/S00216-012-6395-7  0.32
2012 van Duijn E, Barbu IM, Barendregt A, Jore MM, Wiedenheft B, Lundgren M, Westra ER, Brouns SJ, Doudna JA, van der Oost J, Heck AJ. Native tandem and ion mobility mass spectrometry highlight structural and modular similarities in clustered-regularly-interspaced shot-palindromic-repeats (CRISPR)-associated protein complexes from Escherichia coli and Pseudomonas aeruginosa. Molecular & Cellular Proteomics : McP. 11: 1430-41. PMID 22918228 DOI: 10.1074/Mcp.M112.020263  0.364
2012 Rosati S, Thompson NJ, Barendregt A, Hendriks LJ, Bakker AB, de Kruif J, Throsby M, van Duijn E, Heck AJ. Qualitative and semiquantitative analysis of composite mixtures of antibodies by native mass spectrometry. Analytical Chemistry. 84: 7227-32. PMID 22882109 DOI: 10.1021/Ac301611D  0.35
2012 Cappadona S, Baker PR, Cutillas PR, Heck AJ, van Breukelen B. Current challenges in software solutions for mass spectrometry-based quantitative proteomics. Amino Acids. 43: 1087-108. PMID 22821268 DOI: 10.1007/S00726-012-1289-8  0.33
2012 Kükrer B, Barbu IM, Copps J, Hogan P, Taylor SS, van Duijn E, Heck AJ. Conformational isomers of calcineurin follow distinct dissociation pathways. Journal of the American Society For Mass Spectrometry. 23: 1534-43. PMID 22811075 DOI: 10.1007/S13361-012-0441-8  0.367
2012 Mommen GP, van de Waterbeemd B, Meiring HD, Kersten G, Heck AJ, de Jong AP. Unbiased selective isolation of protein N-terminal peptides from complex proteome samples using phospho tagging (PTAG) and TiO(2)-based depletion. Molecular & Cellular Proteomics : McP. 11: 832-42. PMID 22729381 DOI: 10.1074/Mcp.O112.018283  0.372
2012 Cristobal A, Hennrich ML, Giansanti P, Goerdayal SS, Heck AJ, Mohammed S. In-house construction of a UHPLC system enabling the identification of over 4000 protein groups in a single analysis. The Analyst. 137: 3541-8. PMID 22728655 DOI: 10.1039/C2An35445D  0.358
2012 Peng M, Taouatas N, Cappadona S, van Breukelen B, Mohammed S, Scholten A, Heck AJ. Protease bias in absolute protein quantitation. Nature Methods. 9: 524-5. PMID 22669647 DOI: 10.1038/Nmeth.2031  0.337
2012 Kovanich D, Cappadona S, Raijmakers R, Mohammed S, Scholten A, Heck AJ. Applications of stable isotope dimethyl labeling in quantitative proteomics. Analytical and Bioanalytical Chemistry. 404: 991-1009. PMID 22644145 DOI: 10.1007/S00216-012-6070-Z  0.371
2012 Di Palma S, Hennrich ML, Heck AJ, Mohammed S. Recent advances in peptide separation by multidimensional liquid chromatography for proteome analysis. Journal of Proteomics. 75: 3791-813. PMID 22561838 DOI: 10.1016/J.Jprot.2012.04.033  0.359
2012 Aye TT, Low TY, Bjørlykke Y, Barsnes H, Heck AJ, Berven FS. Use of stable isotope dimethyl labeling coupled to selected reaction monitoring to enhance throughput by multiplexing relative quantitation of targeted proteins. Analytical Chemistry. 84: 4999-5006. PMID 22548487 DOI: 10.1021/Ac300596R  0.379
2012 Moreno-Córdoba I, Diago-Navarro E, Barendregt A, Heck AJ, Alfonso C, Díaz-Orejas R, Nieto C, Espinosa M. The toxin-antitoxin proteins relBE2Spn of Streptococcus pneumoniae: characterization and association to their DNA target. Proteins. 80: 1834-46. PMID 22488579 DOI: 10.1002/Prot.24081  0.338
2012 Krijgsheld P, Altelaar AF, Post H, Ringrose JH, Müller WH, Heck AJ, Wösten HA. Spatially resolving the secretome within the mycelium of the cell factory Aspergillus niger. Journal of Proteome Research. 11: 2807-18. PMID 22443316 DOI: 10.1021/Pr201157B  0.339
2012 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, ... ... Heck AJ, et al. Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium. Molecular Systems Biology. 8: 571. PMID 22373819 DOI: 10.1038/Msb.2012.4  0.369
2012 Hennrich ML, van den Toorn HW, Groenewold V, Heck AJ, Mohammed S. Ultra acidic strong cation exchange enabling the efficient enrichment of basic phosphopeptides. Analytical Chemistry. 84: 1804-8. PMID 22303813 DOI: 10.1021/Ac203303T  0.323
2012 Bereszczak JZ, Barbu IM, Tan M, Xia M, Jiang X, van Duijn E, Heck AJ. Structure, stability and dynamics of norovirus P domain derived protein complexes studied by native mass spectrometry. Journal of Structural Biology. 177: 273-82. PMID 22266117 DOI: 10.1016/J.Jsb.2012.01.005  0.319
2012 Altelaar AF, Heck AJ. Trends in ultrasensitive proteomics. Current Opinion in Chemical Biology. 16: 206-13. PMID 22226769 DOI: 10.1016/J.Cbpa.2011.12.011  0.363
2012 Altelaar AF, Navarro D, Boekhorst J, van Breukelen B, Snel B, Mohammed S, Heck AJ. Database independent proteomics analysis of the ostrich and human proteome. Proceedings of the National Academy of Sciences of the United States of America. 109: 407-12. PMID 22198768 DOI: 10.1073/Pnas.1108399108  0.388
2012 Mithoe SC, Boersema PJ, Berke L, Snel B, Heck AJ, Menke FL. Targeted quantitative phosphoproteomics approach for the detection of phospho-tyrosine signaling in plants. Journal of Proteome Research. 11: 438-48. PMID 22074104 DOI: 10.1021/Pr200893K  0.349
2012 Kovanich D, Aye TT, Heck AJ, Scholten A. Probing the specificity of protein-protein interactions by quantitative chemical proteomics. Methods in Molecular Biology (Clifton, N.J.). 803: 167-81. PMID 22065225 DOI: 10.1007/978-1-61779-364-6_12  0.377
2012 Choukrallah MA, Kobi D, Martianov I, Pijnappel WW, Mischerikow N, Ye T, Heck AJ, Timmers HT, Davidson I. Interconversion between active and inactive TATA-binding protein transcription complexes in the mouse genome. Nucleic Acids Research. 40: 1446-59. PMID 22013162 DOI: 10.1093/Nar/Gkr802  0.312
2012 Zoumaro-Djayoon AD, Heck AJ, Muñoz J. Targeted analysis of tyrosine phosphorylation by immuno-affinity enrichment of tyrosine phosphorylated peptides prior to mass spectrometric analysis. Methods (San Diego, Calif.). 56: 268-74. PMID 21945579 DOI: 10.1016/J.Ymeth.2011.09.003  0.367
2012 Heck AJ, Derrick PJ. Ultrahigh Mass Accuracy in Isotope-Selective Collision-Induced Dissociation Using Correlated Sweep Excitation and Sustained Off-Resonance Irradiation:  A Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Case Study on the [M + 2H](2+) Ion of Bradykinin. Analytical Chemistry. 69: 3603-7. PMID 21639284 DOI: 10.1021/Ac970254B  0.311
2011 Munoz J, Low TY, Kok YJ, Chin A, Frese CK, Ding V, Choo A, Heck AJ. The quantitative proteomes of human-induced pluripotent stem cells and embryonic stem cells. Molecular Systems Biology. 7: 550. PMID 22108792 DOI: 10.1038/Msb.2011.84  0.319
2011 Helbig AO, Daran-Lapujade P, van Maris AJ, de Hulster EA, de Ridder D, Pronk JT, Heck AJ, Slijper M. The diversity of protein turnover and abundance under nitrogen-limited steady-state conditions in Saccharomyces cerevisiae. Molecular Biosystems. 7: 3316-26. PMID 21984188 DOI: 10.1039/C1Mb05250K  0.362
2011 Vogels MW, van Balkom BW, Heck AJ, de Haan CA, Rottier PJ, Batenburg JJ, Kaloyanova DV, Helms JB. Quantitative proteomic identification of host factors involved in the Salmonella typhimurium infection cycle. Proteomics. 11: 4477-91. PMID 21919203 DOI: 10.1002/Pmic.201100224  0.357
2011 Di Palma S, Raijmakers R, Heck AJ, Mohammed S. Evaluation of the deuterium isotope effect in zwitterionic hydrophilic interaction liquid chromatography separations for implementation in a quantitative proteomic approach. Analytical Chemistry. 83: 8352-6. PMID 21899334 DOI: 10.1021/Ac2018074  0.357
2011 Rose RJ, Labrijn AF, van den Bremer ET, Loverix S, Lasters I, van Berkel PH, van de Winkel JG, Schuurman J, Parren PW, Heck AJ. Quantitative analysis of the interaction strength and dynamics of human IgG4 half molecules by native mass spectrometry. Structure (London, England : 1993). 19: 1274-82. PMID 21893287 DOI: 10.1016/J.Str.2011.06.016  0.349
2011 Galli M, Muñoz J, Portegijs V, Boxem M, Grill SW, Heck AJ, van den Heuvel S. aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division. Nature Cell Biology. 13: 1132-8. PMID 21857670 DOI: 10.1038/Ncb2315  0.322
2011 Boekhorst J, Boersema PJ, Tops BB, van Breukelen B, Heck AJ, Snel B. Evaluating experimental bias and completeness in comparative phosphoproteomics analysis. Plos One. 6: e23276. PMID 21853102 DOI: 10.1371/Journal.Pone.0023276  0.306
2011 Hennrich ML, Groenewold V, Kops GJ, Heck AJ, Mohammed S. Improving depth in phosphoproteomics by using a strong cation exchange-weak anion exchange-reversed phase multidimensional separation approach. Analytical Chemistry. 83: 7137-43. PMID 21815630 DOI: 10.1021/Ac2015068  0.332
2011 Uetrecht C, Heck AJ. Modern biomolecular mass spectrometry and its role in studying virus structure, dynamics, and assembly. Angewandte Chemie (International Ed. in English). 50: 8248-62. PMID 21793131 DOI: 10.1002/Anie.201008120  0.385
2011 Garcia-Alles LF, Giacometti G, Versluis C, Maveyraud L, de Paepe D, Guiard J, Tranier S, Gilleron M, Prandi J, Hanau D, Heck AJ, Mori L, De Libero G, Puzo G, Mourey L, et al. Crystal structure of human CD1e reveals a groove suited for lipid-exchange processes. Proceedings of the National Academy of Sciences of the United States of America. 108: 13230-5. PMID 21788486 DOI: 10.1073/Pnas.1105627108  0.312
2011 Monti MC, Cohen SX, Fish A, Winterwerp HH, Barendregt A, Friedhoff P, Perrakis A, Heck AJ, Sixma TK, van den Heuvel RH, Lebbink JH. Native mass spectrometry provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS. Nucleic Acids Research. 39: 8052-64. PMID 21737427 DOI: 10.1093/Nar/Gkr498  0.303
2011 de Graaf EL, Altelaar AF, van Breukelen B, Mohammed S, Heck AJ. Improving SRM assay development: a global comparison between triple quadrupole, ion trap, and higher energy CID peptide fragmentation spectra. Journal of Proteome Research. 10: 4334-41. PMID 21726076 DOI: 10.1021/Pr200156B  0.339
2011 Zhou H, Low TY, Hennrich ML, van der Toorn H, Schwend T, Zou H, Mohammed S, Heck AJ. Enhancing the identification of phosphopeptides from putative basophilic kinase substrates using Ti (IV) based IMAC enrichment. Molecular & Cellular Proteomics : McP. 10: M110.006452. PMID 21715320 DOI: 10.1074/Mcp.M110.006452  0.374
2011 Scholten A, Mohammed S, Low TY, Zanivan S, van Veen TA, Delanghe B, Heck AJ. In-depth quantitative cardiac proteomics combining electron transfer dissociation and the metalloendopeptidase Lys-N with the SILAC mouse. Molecular & Cellular Proteomics : McP. 10: O111.008474. PMID 21705516 DOI: 10.1074/Mcp.O111.008474  0.385
2011 Di Palma S, Stange D, van de Wetering M, Clevers H, Heck AJ, Mohammed S. Highly sensitive proteome analysis of FACS-sorted adult colon stem cells. Journal of Proteome Research. 10: 3814-9. PMID 21696214 DOI: 10.1021/Pr200367P  0.334
2011 Pinkse MW, Lemeer S, Heck AJ. A protocol on the use of titanium dioxide chromatography for phosphoproteomics. Methods in Molecular Biology (Clifton, N.J.). 753: 215-28. PMID 21604125 DOI: 10.1007/978-1-61779-148-2_14  0.367
2011 Taouatas N, Mohammed S, Heck AJ. Exploring new proteome space: combining Lys-N proteolytic digestion and strong cation exchange (SCX) separation in peptide-centric MS-driven proteomics. Methods in Molecular Biology (Clifton, N.J.). 753: 157-67. PMID 21604122 DOI: 10.1007/978-1-61779-148-2_11  0.365
2011 Margarucci L, Roest M, Preisinger C, Bleijerveld OB, van Holten TC, Heck AJ, Scholten A. Collagen stimulation of platelets induces a rapid spatial response of cAMP and cGMP signaling scaffolds. Molecular Biosystems. 7: 2311-9. PMID 21597619 DOI: 10.1039/C1Mb05145H  0.301
2011 Di Palma S, Boersema PJ, Heck AJ, Mohammed S. Zwitterionic hydrophilic interaction liquid chromatography (ZIC-HILIC and ZIC-cHILIC) provide high resolution separation and increase sensitivity in proteome analysis. Analytical Chemistry. 83: 3440-7. PMID 21443167 DOI: 10.1021/Ac103312E  0.359
2011 Ding VM, Boersema PJ, Foong LY, Preisinger C, Koh G, Natarajan S, Lee DY, Boekhorst J, Snel B, Lemeer S, Heck AJ, Choo A. Tyrosine phosphorylation profiling in FGF-2 stimulated human embryonic stem cells. Plos One. 6: e17538. PMID 21437283 DOI: 10.1371/Journal.Pone.0017538  0.31
2011 Frese CK, Altelaar AF, Hennrich ML, Nolting D, Zeller M, Griep-Raming J, Heck AJ, Mohammed S. Improved peptide identification by targeted fragmentation using CID, HCD and ETD on an LTQ-Orbitrap Velos. Journal of Proteome Research. 10: 2377-88. PMID 21413819 DOI: 10.1021/Pr1011729  0.353
2011 Tseng YH, Uetrecht C, Heck AJ, Peng WP. Interpreting the charge state assignment in electrospray mass spectra of bioparticles. Analytical Chemistry. 83: 1960-8. PMID 21361376 DOI: 10.1021/Ac102676Z  0.316
2011 Mischerikow N, Heck AJ. Targeted large-scale analysis of protein acetylation. Proteomics. 11: 571-89. PMID 21246731 DOI: 10.1002/Pmic.201000397  0.341
2011 Dewalick S, Bexkens ML, van Balkom BW, Wu YP, Smit CH, Hokke CH, de Groot PG, Heck AJ, Tielens AG, van Hellemond JJ. The proteome of the insoluble Schistosoma mansoni eggshell skeleton. International Journal For Parasitology. 41: 523-32. PMID 21236260 DOI: 10.1016/J.Ijpara.2010.12.005  0.377
2011 Karagöz GE, Duarte AM, Ippel H, Uetrecht C, Sinnige T, van Rosmalen M, Hausmann J, Heck AJ, Boelens R, Rüdiger SG. N-terminal domain of human Hsp90 triggers binding to the cochaperone p23. Proceedings of the National Academy of Sciences of the United States of America. 108: 580-5. PMID 21183720 DOI: 10.1073/Pnas.1011867108  0.314
2010 van Beers JJ, Raijmakers R, Alexander LE, Stammen-Vogelzangs J, Lokate AM, Heck AJ, Schasfoort RB, Pruijn GJ. Mapping of citrullinated fibrinogen B-cell epitopes in rheumatoid arthritis by imaging surface plasmon resonance. Arthritis Research & Therapy. 12: R219. PMID 21182780 DOI: 10.1186/Ar3205  0.321
2010 Snijder J, Rose RJ, Raijmakers R, Heck AJ. Site-specific methionine oxidation in calmodulin affects structural integrity and interaction with Ca2+/calmodulin-dependent protein kinase II. Journal of Structural Biology. 174: 187-95. PMID 21156208 DOI: 10.1016/J.Jsb.2010.12.002  0.31
2010 Helbig AO, Rosati S, Pijnappel PW, van Breukelen B, Timmers MH, Mohammed S, Slijper M, Heck AJ. Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels. Bmc Genomics. 11: 685. PMID 21126336 DOI: 10.1186/1471-2164-11-685  0.334
2010 Wijte D, van Baar BL, Heck AJ, Altelaar AF. Probing the proteome response to toluene exposure in the solvent tolerant Pseudomonas putida S12. Journal of Proteome Research. 10: 394-403. PMID 20979388 DOI: 10.1021/Pr100401N  0.337
2010 Raijmakers R, Neerincx P, Mohammed S, Heck AJ. Cleavage specificities of the brother and sister proteases Lys-C and Lys-N. Chemical Communications (Cambridge, England). 46: 8827-9. PMID 20953479 DOI: 10.1039/C0Cc02523B  0.304
2010 Hennrich ML, Mohammed S, Altelaar AF, Heck AJ. Dimethyl isotope labeling assisted de novo peptide sequencing. Journal of the American Society For Mass Spectrometry. 21: 1957-65. PMID 20850342 DOI: 10.1016/J.Jasms.2010.08.007  0.345
2010 Kim S, Mischerikow N, Bandeira N, Navarro JD, Wich L, Mohammed S, Heck AJ, Pevzner PA. The generating function of CID, ETD, and CID/ETD pairs of tandem mass spectra: applications to database search. Molecular & Cellular Proteomics : McP. 9: 2840-52. PMID 20829449 DOI: 10.1074/Mcp.M110.003731  0.347
2010 Mischerikow N, van Nierop P, Li KW, Bernstein HG, Smit AB, Heck AJ, Altelaar AF. Gaining efficiency by parallel quantification and identification of iTRAQ-labeled peptides using HCD and decision tree guided CID/ETD on an LTQ Orbitrap. The Analyst. 135: 2643-52. PMID 20714520 DOI: 10.1039/C0An00267D  0.351
2010 Aye TT, Scholten A, Taouatas N, Varro A, Van Veen TA, Vos MA, Heck AJ. Proteome-wide protein concentrations in the human heart. Molecular Biosystems. 6: 1917-27. PMID 20596566 DOI: 10.1039/C004495D  0.391
2010 Taouatas N, Heck AJ, Mohammed S. Evaluation of metalloendopeptidase Lys-N protease performance under different sample handling conditions. Journal of Proteome Research. 9: 4282-8. PMID 20540561 DOI: 10.1021/Pr100341E  0.33
2010 Staals RH, Bronkhorst AW, Schilders G, Slomovic S, Schuster G, Heck AJ, Raijmakers R, Pruijn GJ. Dis3-like 1: a novel exoribonuclease associated with the human exosome. The Embo Journal. 29: 2358-67. PMID 20531389 DOI: 10.1038/Emboj.2010.122  0.302
2010 Heck AJ. At the interface of interaction proteomics and structural biology. Molecular & Cellular Proteomics : McP. 9: 1633. PMID 20522653 DOI: 10.1074/Mcp.E110.001511  0.407
2010 Girardi E, Wang J, Mac TT, Versluis C, Bhowruth V, Besra G, Heck AJ, Van Rhijn I, Zajonc DM. Crystal structure of bovine CD1b3 with endogenously bound ligands. Journal of Immunology (Baltimore, Md. : 1950). 185: 376-86. PMID 20519644 DOI: 10.4049/Jimmunol.1000042  0.314
2010 Spedale G, Mischerikow N, Heck AJ, Timmers HT, Pijnappel WW. Identification of Pep4p as the protease responsible for formation of the SAGA-related SLIK protein complex. The Journal of Biological Chemistry. 285: 22793-9. PMID 20498363 DOI: 10.1074/Jbc.M110.108787  0.364
2010 Alpert AJ, Petritis K, Kangas L, Smith RD, Mechtler K, Mitulović G, Mohammed S, Heck AJ. Peptide orientation affects selectivity in ion-exchange chromatography. Analytical Chemistry. 82: 5253-9. PMID 20481592 DOI: 10.1021/Ac100651K  0.314
2010 Shoemaker GK, van Duijn E, Crawford SE, Uetrecht C, Baclayon M, Roos WH, Wuite GJ, Estes MK, Prasad BV, Heck AJ. Norwalk virus assembly and stability monitored by mass spectrometry. Molecular & Cellular Proteomics : McP. 9: 1742-51. PMID 20418222 DOI: 10.1074/Mcp.M900620-Mcp200  0.341
2010 Kovanich D, van der Heyden MA, Aye TT, van Veen TA, Heck AJ, Scholten A. Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase. Chembiochem : a European Journal of Chemical Biology. 11: 963-71. PMID 20394097 DOI: 10.1002/Cbic.201000058  0.356
2010 Mischerikow N, Altelaar AF, Navarro JD, Mohammed S, Heck AJ. Comparative assessment of site assignments in CID and electron transfer dissociation spectra of phosphopeptides discloses limited relocation of phosphate groups. Molecular & Cellular Proteomics : McP. 9: 2140-8. PMID 20233845 DOI: 10.1074/Mcp.M900619-Mcp200  0.352
2010 Fu CY, Uetrecht C, Kang S, Morais MC, Heck AJ, Walter MR, Prevelige PE. A docking model based on mass spectrometric and biochemical data describes phage packaging motor incorporation. Molecular & Cellular Proteomics : McP. 9: 1764-73. PMID 20124351 DOI: 10.1074/Mcp.M900625-Mcp200  0.364
2010 Helbig AO, Heck AJ, Slijper M. Exploring the membrane proteome--challenges and analytical strategies. Journal of Proteomics. 73: 868-78. PMID 20096812 DOI: 10.1016/J.Jprot.2010.01.005  0.335
2010 Van Hoof D, Dormeyer W, Braam SR, Passier R, Monshouwer-Kloots J, Ward-van Oostwaard D, Heck AJ, Krijgsveld J, Mummery CL. Identification of cell surface proteins for antibody-based selection of human embryonic stem cell-derived cardiomyocytes. Journal of Proteome Research. 9: 1610-8. PMID 20088484 DOI: 10.1021/Pr901138A  0.356
2010 van Breukelen B, Georgiou A, Drugan MM, Taouatas N, Mohammed S, Heck AJ. LysNDeNovo: an algorithm enabling de novo sequencing of Lys-N generated peptides fragmented by electron transfer dissociation. Proteomics. 10: 1196-201. PMID 20077410 DOI: 10.1002/Pmic.200900405  0.326
2010 Raijmakers R, Kraiczek K, de Jong AP, Mohammed S, Heck AJ. Exploring the human leukocyte phosphoproteome using a microfluidic reversed-phase-TiO2-reversed-phase high-performance liquid chromatography phosphochip coupled to a quadrupole time-of-flight mass spectrometer. Analytical Chemistry. 82: 824-32. PMID 20058876 DOI: 10.1021/Ac901764G  0.388
2010 Barbu IM, Smith DF, van Breukelen B, van der Burgt YE, Duursma MC, Heck AJ, Heeren RM, Krijgsveld J. On-the-fly targeted selection of labeled peptides in liquid chromatography/mass spectrometry based quantitative proteomics. Rapid Communications in Mass Spectrometry : Rcm. 24: 239-41. PMID 20013948 DOI: 10.1002/Rcm.4385  0.346
2010 Gouw JW, Krijgsveld J, Heck AJ. Quantitative proteomics by metabolic labeling of model organisms. Molecular & Cellular Proteomics : McP. 9: 11-24. PMID 19955089 DOI: 10.1074/Mcp.R900001-Mcp200  0.39
2010 Tops BB, Gauci S, Heck AJ, Krijgsveld J. Worms from venus and mars: proteomics profiling of sexual differences in Caenorhabditis elegans using in vivo 15N isotope labeling. Journal of Proteome Research. 9: 341-51. PMID 19916504 DOI: 10.1021/Pr900678J  0.363
2010 Mortensen P, Gouw JW, Olsen JV, Ong SE, Rigbolt KT, Bunkenborg J, Cox J, Foster LJ, Heck AJ, Blagoev B, Andersen JS, Mann M. MSQuant, an open source platform for mass spectrometry-based quantitative proteomics. Journal of Proteome Research. 9: 393-403. PMID 19888749 DOI: 10.1021/Pr900721E  0.377
2010 Boersema PJ, Foong LY, Ding VM, Lemeer S, van Breukelen B, Philp R, Boekhorst J, Snel B, den Hertog J, Choo AB, Heck AJ. In-depth qualitative and quantitative profiling of tyrosine phosphorylation using a combination of phosphopeptide immunoaffinity purification and stable isotope dimethyl labeling. Molecular & Cellular Proteomics : McP. 9: 84-99. PMID 19770167 DOI: 10.1074/Mcp.M900291-Mcp200  0.372
2010 Helbig AO, de Groot MJ, van Gestel RA, Mohammed S, de Hulster EA, Luttik MA, Daran-Lapujade P, Pronk JT, Heck AJ, Slijper M. A three-way proteomics strategy allows differential analysis of yeast mitochondrial membrane protein complexes under anaerobic and aerobic conditions. Proteomics. 9: 4787-98. PMID 19750512 DOI: 10.1002/Pmic.200800951  0.333
2009 Uetrecht C, Rose RJ, van Duijn E, Lorenzen K, Heck AJ. Ion mobility mass spectrometry of proteins and protein assemblies. Chemical Society Reviews. 39: 1633-55. PMID 20419213 DOI: 10.1039/B914002F  0.403
2009 van Anken E, Pena F, Hafkemeijer N, Christis C, Romijn EP, Grauschopf U, Oorschot VM, Pertel T, Engels S, Ora A, Lástun V, Glockshuber R, Klumperman J, Heck AJ, Luban J, et al. Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1. Proceedings of the National Academy of Sciences of the United States of America. 106: 17019-24. PMID 19805154 DOI: 10.1073/Pnas.0903036106  0.329
2009 van Gestel RA, van Solinge WW, van der Toorn HW, Rijksen G, Heck AJ, van Wijk R, Slijper M. Quantitative erythrocyte membrane proteome analysis with Blue-native/SDS PAGE. Journal of Proteomics. 73: 456-65. PMID 19778645 DOI: 10.1016/J.Jprot.2009.08.010  0.32
2009 de Wit NC, Heck AJ, Thornton S. The effect of oxytocin and an oxytocin antagonist on the human myometrial proteome. Reproductive Sciences (Thousand Oaks, Calif.). 17: 40-6. PMID 19767541 DOI: 10.1177/1933719109345287  0.326
2009 Mischerikow N, Spedale G, Altelaar AF, Timmers HT, Pijnappel WW, Heck AJ. In-depth profiling of post-translational modifications on the related transcription factor complexes TFIID and SAGA. Journal of Proteome Research. 8: 5020-30. PMID 19731963 DOI: 10.1021/Pr900449E  0.355
2009 Hennrich ML, Boersema PJ, van den Toorn H, Mischerikow N, Heck AJ, Mohammed S. Effect of chemical modifications on peptide fragmentation behavior upon electron transfer induced dissociation. Analytical Chemistry. 81: 7814-22. PMID 19689115 DOI: 10.1021/Ac901108G  0.335
2009 Raijmakers R, Heck AJ, Mohammed S. Assessing biological variation and protein processing in primary human leukocytes by automated multiplex stable isotope labeling coupled to 2 dimensional peptide separation. Molecular Biosystems. 5: 992-1003. PMID 19668865 DOI: 10.1039/B901873E  0.407
2009 Van Hoof D, Muñoz J, Braam SR, Pinkse MW, Linding R, Heck AJ, Mummery CL, Krijgsveld J. Phosphorylation dynamics during early differentiation of human embryonic stem cells. Cell Stem Cell. 5: 214-26. PMID 19664995 DOI: 10.1016/J.Stem.2009.05.021  0.351
2009 Lemeer S, Heck AJ. The phosphoproteomics data explosion. Current Opinion in Chemical Biology. 13: 414-20. PMID 19620020 DOI: 10.1016/J.Cbpa.2009.06.022  0.34
2009 Sneekes EJ, Han J, Elliot M, Ausio J, Swart R, Heck AJ, Borchers C. Accurate molecular weight analysis of histones using FFE and RP-HPLC on monolithic capillary columns. Journal of Separation Science. 32: 2691-8. PMID 19569095 DOI: 10.1002/Jssc.200800627  0.305
2009 Lau NC, Kolkman A, van Schaik FM, Mulder KW, Pijnappel WW, Heck AJ, Timmers HT. Human Ccr4-Not complexes contain variable deadenylase subunits. The Biochemical Journal. 422: 443-53. PMID 19558367 DOI: 10.1042/Bj20090500  0.321
2009 Boersema PJ, Mohammed S, Heck AJ. Phosphopeptide fragmentation and analysis by mass spectrometry. Journal of Mass Spectrometry : Jms. 44: 861-78. PMID 19504542 DOI: 10.1002/Jms.1599  0.374
2009 Gauci S, Veenhoff LM, Heck AJ, Krijgsveld J. Orthogonal separation techniques for the characterization of the yeast nuclear proteome. Journal of Proteome Research. 8: 3451-63. PMID 19453177 DOI: 10.1021/Pr9000948  0.413
2009 Schaaij-Visser TB, Brakenhoff RH, Jansen JW, O'Flaherty MC, Smeets SJ, Heck AJ, Slijper M. Comparative proteome analysis to explore p53 pathway disruption in head and neck carcinogenesis. Journal of Proteomics. 72: 803-14. PMID 19446051 DOI: 10.1016/J.Jprot.2009.05.001  0.315
2009 Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Analytical Chemistry. 81: 4493-501. PMID 19413330 DOI: 10.1021/Ac9004309  0.35
2009 De Vries E, Bakker N, Krijgsveld J, Knox DP, Heck AJ, Yatsuda AP. An AC-5 cathepsin B-like protease purified from Haemonchus contortus excretory secretory products shows protective antigen potential for lambs. Veterinary Research. 40: 41. PMID 19401141 DOI: 10.1051/Vetres/2009025  0.315
2009 Dadvar P, O'Flaherty M, Scholten A, Rumpel K, Heck AJ. A chemical proteomics based enrichment technique targeting the interactome of the PDE5 inhibitor PF-4540124. Molecular Biosystems. 5: 472-82. PMID 19381362 DOI: 10.1039/B815709J  0.354
2009 Pinkse MW, Rijkers DT, Dostmann WR, Heck AJ. Mode of action of cGMP-dependent protein kinase-specific inhibitors probed by photoaffinity cross-linking mass spectrometry. The Journal of Biological Chemistry. 284: 16354-68. PMID 19369251 DOI: 10.1074/Jbc.M808521200  0.369
2009 Gouw JW, Pinkse MW, Vos HR, Moshkin Y, Verrijzer CP, Heck AJ, Krijgsveld J. In vivo stable isotope labeling of fruit flies reveals post-transcriptional regulation in the maternal-to-zygotic transition. Molecular & Cellular Proteomics : McP. 8: 1566-78. PMID 19321433 DOI: 10.1074/Mcp.M900114-Mcp200  0.371
2009 Boersema PJ, Raijmakers R, Lemeer S, Mohammed S, Heck AJ. Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics. Nature Protocols. 4: 484-94. PMID 19300442 DOI: 10.1038/Nprot.2009.21  0.347
2009 Altelaar AF, Mohammed S, Brans MA, Adan RA, Heck AJ. Improved identification of endogenous peptides from murine nervous tissue by multiplexed peptide extraction methods and multiplexed mass spectrometric analysis. Journal of Proteome Research. 8: 870-6. PMID 19152261 DOI: 10.1021/Pr800449N  0.348
2009 van Duijn E, Barendregt A, Synowsky S, Versluis C, Heck AJ. Chaperonin complexes monitored by ion mobility mass spectrometry. Journal of the American Chemical Society. 131: 1452-9. PMID 19138114 DOI: 10.1021/Ja8055134  0.401
2009 Boersema PJ, Taouatas N, Altelaar AF, Gouw JW, Ross PL, Pappin DJ, Heck AJ, Mohammed S. Straightforward and de novo peptide sequencing by MALDI-MS/MS using a Lys-N metalloendopeptidase. Molecular & Cellular Proteomics : McP. 8: 650-60. PMID 19043101 DOI: 10.1074/Mcp.M800249-Mcp200  0.365
2009 Boersema PJ, Aye TT, van Veen TA, Heck AJ, Mohammed S. Triplex protein quantification based on stable isotope labeling by peptide dimethylation applied to cell and tissue lysates. Proteomics. 8: 4624-32. PMID 18850632 DOI: 10.1002/Pmic.200800297  0.371
2008 Van Hoof D, Heck AJ, Krijgsveld J, Mummery CL. Proteomics and human embryonic stem cells. Stem Cell Research. 1: 169-82. PMID 19383398 DOI: 10.1016/J.Scr.2008.05.003  0.386
2008 Aye TT, Mohammed S, van den Toorn HW, van Veen TA, van der Heyden MA, Scholten A, Heck AJ. Selectivity in enrichment of cAMP-dependent protein kinase regulatory subunits type I and type II and their interactors using modified cAMP affinity resins. Molecular & Cellular Proteomics : McP. 8: 1016-28. PMID 19119138 DOI: 10.1074/Mcp.M800226-Mcp200  0.381
2008 Synowsky SA, van Wijk M, Raijmakers R, Heck AJ. Comparative multiplexed mass spectrometric analyses of endogenously expressed yeast nuclear and cytoplasmic exosomes. Journal of Molecular Biology. 385: 1300-13. PMID 19046973 DOI: 10.1016/J.Jmb.2008.11.011  0.411
2008 Heck AJ. Native mass spectrometry: a bridge between interactomics and structural biology. Nature Methods. 5: 927-33. PMID 18974734 DOI: 10.1038/Nmeth.1265  0.367
2008 Geels RB, Calmat S, Heck AJ, van der Vies SM, Heeren RM. Thermal activation of the co-chaperonins GroES and gp31 probed by mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 22: 3633-41. PMID 18972453 DOI: 10.1002/Rcm.3782  0.344
2008 Taouatas N, Altelaar AF, Drugan MM, Helbig AO, Mohammed S, Heck AJ. Strong cation exchange-based fractionation of Lys-N-generated peptides facilitates the targeted analysis of post-translational modifications. Molecular & Cellular Proteomics : McP. 8: 190-200. PMID 18824475 DOI: 10.1074/Mcp.M800285-Mcp200  0.351
2008 Gouw JW, Tops BB, Mortensen P, Heck AJ, Krijgsveld J. Optimizing identification and quantitation of 15N-labeled proteins in comparative proteomics. Analytical Chemistry. 80: 7796-803. PMID 18808151 DOI: 10.1021/Ac801249V  0.349
2008 van Vlijmen T, Vleugel M, Evers M, Mohammed S, Wulf PS, Heck AJ, Hoogenraad CC, van der Sluijs P. A unique residue in rab3c determines the interaction with novel binding protein Zwint-1. Febs Letters. 582: 2838-42. PMID 18625232 DOI: 10.1016/J.Febslet.2008.07.012  0.337
2008 Uetrecht C, Versluis C, Watts NR, Roos WH, Wuite GJ, Wingfield PT, Steven AC, Heck AJ. High-resolution mass spectrometry of viral assemblies: molecular composition and stability of dimorphic hepatitis B virus capsids. Proceedings of the National Academy of Sciences of the United States of America. 105: 9216-20. PMID 18587050 DOI: 10.1073/Pnas.0800406105  0.302
2008 Lemeer S, Jopling C, Gouw J, Mohammed S, Heck AJ, Slijper M, den Hertog J. Comparative phosphoproteomics of zebrafish Fyn/Yes morpholino knockdown embryos. Molecular & Cellular Proteomics : McP. 7: 2176-87. PMID 18550893 DOI: 10.1074/Mcp.M800081-Mcp200  0.339
2008 Raijmakers R, Berkers CR, de Jong A, Ovaa H, Heck AJ, Mohammed S. Automated online sequential isotope labeling for protein quantitation applied to proteasome tissue-specific diversity. Molecular & Cellular Proteomics : McP. 7: 1755-62. PMID 18534969 DOI: 10.1074/Mcp.M800093-Mcp200  0.372
2008 Visser NF, Heck AJ. Surface plasmon resonance mass spectrometry in proteomics. Expert Review of Proteomics. 5: 425-33. PMID 18532910 DOI: 10.1586/14789450.5.3.425  0.402
2008 Ringrose JH, van Solinge WW, Mohammed S, O'Flaherty MC, van Wijk R, Heck AJ, Slijper M. Highly efficient depletion strategy for the two most abundant erythrocyte soluble proteins improves proteome coverage dramatically. Journal of Proteome Research. 7: 3060-3. PMID 18494517 DOI: 10.1021/Pr8001029  0.343
2008 Sneekes EJ, Damen M, Swart R, Heck AJ. Isoform separation of a multi-acetylated protein using capillary polystyrene-divinylbenzene monolithic columns. Journal of Chromatography. A. 1194: 199-204. PMID 18486138 DOI: 10.1016/J.Chroma.2008.04.051  0.354
2008 Lorenzen K, Olia AS, Uetrecht C, Cingolani G, Heck AJ. Determination of stoichiometry and conformational changes in the first step of the P22 tail assembly. Journal of Molecular Biology. 379: 385-96. PMID 18448123 DOI: 10.1016/J.Jmb.2008.02.017  0.342
2008 Taouatas N, Drugan MM, Heck AJ, Mohammed S. Straightforward ladder sequencing of peptides using a Lys-N metalloendopeptidase. Nature Methods. 5: 405-7. PMID 18425140 DOI: 10.1038/Nmeth.1204  0.341
2008 Mohammed S, Lorenzen K, Kerkhoven R, van Breukelen B, Vannini A, Cramer P, Heck AJ. Multiplexed proteomics mapping of yeast RNA polymerase II and III allows near-complete sequence coverage and reveals several novel phosphorylation sites. Analytical Chemistry. 80: 3584-92. PMID 18416563 DOI: 10.1021/Ac7024283  0.321
2008 Scholten A, Aye TT, Heck AJ. A multi-angular mass spectrometric view at cyclic nucleotide dependent protein kinases: in vivo characterization and structure/function relationships. Mass Spectrometry Reviews. 27: 331-53. PMID 18381623 DOI: 10.1002/Mas.20166  0.406
2008 Mohammed S, Kraiczek K, Pinkse MW, Lemeer S, Benschop JJ, Heck AJ. Chip-Based Enrichment and NanoLC-MS/MS Analysis of Phosphopeptides from Whole Lysates. Journal of Proteome Research. 7: 1565-71. PMID 18307298 DOI: 10.1021/Pr700635A  0.384
2008 Lemeer S, Pinkse MW, Mohammed S, van Breukelen B, den Hertog J, Slijper M, Heck AJ. Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo. Journal of Proteome Research. 7: 1555-64. PMID 18307296 DOI: 10.1021/Pr700667W  0.348
2008 Boersema PJ, Mohammed S, Heck AJ. Hydrophilic interaction liquid chromatography (HILIC) in proteomics. Analytical and Bioanalytical Chemistry. 391: 151-9. PMID 18264818 DOI: 10.1007/S00216-008-1865-7  0.354
2008 Mousson F, Kolkman A, Pijnappel WW, Timmers HT, Heck AJ. Quantitative proteomics reveals regulation of dynamic components within TATA-binding protein (TBP) transcription complexes. Molecular & Cellular Proteomics : McP. 7: 845-52. PMID 18087068 DOI: 10.1074/Mcp.M700306-Mcp200  0.382
2008 Kitagawa N, Mazon H, Heck AJ, Wilkens S. Stoichiometry of the peripheral stalk subunits E and G of yeast V1-ATPase determined by mass spectrometry. The Journal of Biological Chemistry. 283: 3329-37. PMID 18055462 DOI: 10.1074/Jbc.M707924200  0.353
2008 Pinkse MW, Mohammed S, Gouw JW, van Breukelen B, Vos HR, Heck AJ. Highly robust, automated, and sensitive online TiO2-based phosphoproteomics applied to study endogenous phosphorylation in Drosophila melanogaster. Journal of Proteome Research. 7: 687-97. PMID 18034456 DOI: 10.1021/Pr700605Z  0.346
2008 Visser NF, Scholten A, van den Heuvel RH, Heck AJ. Surface-plasmon-resonance-based chemical proteomics: efficient specific extraction and semiquantitative identification of cyclic nucleotide-binding proteins from cellular lysates by using a combination of surface plasmon resonance, sequential elution and liquid chromatography-tandem mass spectrometry. Chembiochem : a European Journal of Chemical Biology. 8: 298-305. PMID 17206730 DOI: 10.1002/Cbic.200600449  0.401
2008 Toorn HWvd, Mohammed S, Gouw JW, Breukelen Bv, Heck AJ. Targeted SCX Based Peptide Fractionation for Optimal Sequencing by Collision Induced, and Electron Transfer Dissociation Journal of Proteomics & Bioinformatics. 1: 379-388. DOI: 10.4172/Jpb.1000047  0.347
2007 Alverdi V, Mazon H, Versluis C, Hemrika W, Esposito G, van den Heuvel R, Scholten A, Heck AJ. cGMP-binding prepares PKG for substrate binding by disclosing the C-terminal domain. Journal of Molecular Biology. 375: 1380-93. PMID 18082764 DOI: 10.1016/J.Jmb.2007.11.053  0.346
2007 Synowsky SA, Heck AJ. The yeast Ski complex is a hetero-tetramer. Protein Science : a Publication of the Protein Society. 17: 119-25. PMID 18042677 DOI: 10.1110/Ps.073155908  0.324
2007 Dormeyer W, Mohammed S, Breukelen Bv, Krijgsveld J, Heck AJ. Targeted analysis of protein termini. Journal of Proteome Research. 6: 4634-45. PMID 17927228 DOI: 10.1021/Pr070375K  0.376
2007 Lemeer S, Ruijtenbeek R, Pinkse MW, Jopling C, Heck AJ, den Hertog J, Slijper M. Endogenous phosphotyrosine signaling in zebrafish embryos. Molecular & Cellular Proteomics : McP. 6: 2088-99. PMID 17698882 DOI: 10.1074/Mcp.M600482-Mcp200  0.347
2007 Taylor CF, Paton NW, Lilley KS, Binz PA, Julian RK, Jones AR, Zhu W, Apweiler R, Aebersold R, Deutsch EW, Dunn MJ, Heck AJ, Leitner A, Macht M, Mann M, et al. The minimum information about a proteomics experiment (MIAPE). Nature Biotechnology. 25: 887-93. PMID 17687369 DOI: 10.1038/Nbt1329  0.338
2007 Lemeer S, Jopling C, Naji F, Ruijtenbeek R, Slijper M, Heck AJ, den Hertog J. Protein-tyrosine kinase activity profiling in knock down zebrafish embryos. Plos One. 2: e581. PMID 17611617 DOI: 10.1371/Journal.Pone.0000581  0.351
2007 Brunner E, Ahrens CH, Mohanty S, Baetschmann H, Loevenich S, Potthast F, Deutsch EW, Panse C, de Lichtenberg U, Rinner O, Lee H, Pedrioli PG, Malmstrom J, Koehler K, Schrimpf S, ... ... Heck AJ, et al. A high-quality catalog of the Drosophila melanogaster proteome. Nature Biotechnology. 25: 576-83. PMID 17450130 DOI: 10.1038/Nbt1300  0.356
2007 Scholten A, van Veen TA, Vos MA, Heck AJ. Diversity of cAMP-dependent protein kinase isoforms and their anchoring proteins in mouse ventricular tissue. Journal of Proteome Research. 6: 1705-17. PMID 17432891 DOI: 10.1021/Pr060601A  0.364
2007 Stanley WA, Versluis K, Schultz C, Heck AJ, Wilmanns M. Investigation of the ligand spectrum of human sterol carrier protein 2 using a direct mass spectrometry assay. Archives of Biochemistry and Biophysics. 461: 50-8. PMID 17418802 DOI: 10.1016/J.Abb.2007.02.026  0.355
2007 Scholten A, Fuss H, Heck AJ, Dostmann WR. The hinge region operates as a stability switch in cGMP-dependent protein kinase I alpha. The Febs Journal. 274: 2274-86. PMID 17403045 DOI: 10.1111/J.1742-4658.2007.05764.X  0.348
2007 Monti MC, Hernández-Arriaga AM, Kamphuis MB, López-Villarejo J, Heck AJ, Boelens R, Díaz-Orejas R, van den Heuvel RH. Interactions of Kid-Kis toxin-antitoxin complexes with the parD operator-promoter region of plasmid R1 are piloted by the Kis antitoxin and tuned by the stoichiometry of Kid-Kis oligomers. Nucleic Acids Research. 35: 1737-49. PMID 17317682 DOI: 10.1093/Nar/Gkm073  0.311
2007 Benschop JJ, Mohammed S, O'Flaherty M, Heck AJ, Slijper M, Menke FL. Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis. Molecular & Cellular Proteomics : McP. 6: 1198-214. PMID 17317660 DOI: 10.1074/Mcp.M600429-Mcp200  0.37
2007 Mazon H, Gábor K, Leys D, Heck AJ, van der Oost J, van den Heuvel RH. Transcriptional activation by CprK1 is regulated by protein structural changes induced by effector binding and redox state. The Journal of Biological Chemistry. 282: 11281-90. PMID 17303561 DOI: 10.1074/Jbc.M611177200  0.337
2007 Mihalca R, van der Burgt YE, Heck AJ, Heeren RM. Disulfide bond cleavages observed in SORI-CID of three nonapeptides complexed with divalent transition-metal cations. Journal of Mass Spectrometry : Jms. 42: 450-8. PMID 17295413 DOI: 10.1002/Jms.1175  0.358
2007 Boersema PJ, Divecha N, Heck AJ, Mohammed S. Evaluation and optimization of ZIC-HILIC-RP as an alternative MudPIT strategy. Journal of Proteome Research. 6: 937-46. PMID 17256977 DOI: 10.1021/Pr060589M  0.356
2007 Kamphuis MB, Monti MC, van den Heuvel RH, Santos-Sierra S, Folkers GE, Lemonnier M, Díaz-Orejas R, Heck AJ, Boelens R. Interactions between the toxin Kid of the bacterial parD system and the antitoxins Kis and MazE. Proteins. 67: 219-31. PMID 17206710 DOI: 10.1002/Prot.21254  0.366
2007 van den Heuvel RH, van Duijn E, Mazon H, Synowsky SA, Lorenzen K, Versluis C, Brouns SJ, Langridge D, van der Oost J, Hoyes J, Heck AJ. Improving the performance of a quadrupole time-of-flight instrument for macromolecular mass spectrometry. Analytical Chemistry. 78: 7473-83. PMID 17073415 DOI: 10.1021/Ac061039A  0.392
2007 Poliakov A, van Duijn E, Lander G, Fu CY, Johnson JE, Prevelige PE, Heck AJ. Macromolecular mass spectrometry and electron microscopy as complementary tools for investigation of the heterogeneity of bacteriophage portal assemblies. Journal of Structural Biology. 157: 371-83. PMID 17064935 DOI: 10.1016/J.Jsb.2006.09.003  0.327
2007 Wijte D, de Jong AL, Mol MA, van Baar BL, Heck AJ. ProteomIQ blue, a potent post-stain for the visualization and subsequent mass spectrometry based identification of fluorescent stained proteins on 2D-gels. Journal of Proteome Research. 5: 2033-8. PMID 16889427 DOI: 10.1021/Pr060076F  0.371
2007 van Breukelen B, Barendregt A, Heck AJ, van den Heuvel RH. Resolving stoichiometries and oligomeric states of glutamate synthase protein complexes with curve fitting and simulation of electrospray mass spectra. Rapid Communications in Mass Spectrometry : Rcm. 20: 2490-6. PMID 16862623 DOI: 10.1002/Rcm.2620  0.351
2007 Lorenzen K, Versluis C, van Duijn E, van den Heuvel RH, Heck AJ. Optimizing macromolecular tandem mass spectrometry of large non-covalent complexes using heavy collision gases International Journal of Mass Spectrometry. 268: 198-206. DOI: 10.1016/J.Ijms.2007.06.012  0.357
2007 Geels RB, van der Vies SM, Heck AJ, Heeren RM. Comparative gas-phase activation of two similar non-covalent heptameric protein complexes: gp31 and GroES International Journal of Mass Spectrometry. 265: 159-168. DOI: 10.1016/J.Ijms.2007.02.008  0.354
2006 Dirksen EH, Pinkse MW, Rijkers DT, Cloos J, Liskamp RM, Slijper M, Heck AJ. Investigating the dynamic nature of the interactions between nuclear proteins and histones upon DNA damage using an immobilized peptide chemical proteomics approach. Journal of Proteome Research. 5: 2380-8. PMID 16944950 DOI: 10.1021/Pr060278B  0.35
2006 Van Hoof D, Mummery CL, Heck AJ, Krijgsveld J. Embryonic stem cell proteomics. Expert Review of Proteomics. 3: 427-37. PMID 16901201 DOI: 10.1586/14789450.3.4.427  0.32
2006 Synowsky SA, van den Heuvel RH, Mohammed S, Pijnappel PW, Heck AJ. Probing genuine strong interactions and post-translational modifications in the heterogeneous yeast exosome protein complex. Molecular & Cellular Proteomics : McP. 5: 1581-92. PMID 16829593 DOI: 10.1074/Mcp.M600043-Mcp200  0.432
2006 Krijgsveld J, Gauci S, Dormeyer W, Heck AJ. In-gel isoelectric focusing of peptides as a tool for improved protein identification. Journal of Proteome Research. 5: 1721-30. PMID 16823980 DOI: 10.1021/Pr0601180  0.398
2006 Scholten A, Poh MK, van Veen TA, van Breukelen B, Vos MA, Heck AJ. Analysis of the cGMP/cAMP interactome using a chemical proteomics approach in mammalian heart tissue validates sphingosine kinase type 1-interacting protein as a genuine and highly abundant AKAP. Journal of Proteome Research. 5: 1435-47. PMID 16739995 DOI: 10.1021/Pr0600529  0.383
2006 Kolkman A, Daran-Lapujade P, Fullaondo A, Olsthoorn MM, Pronk JT, Slijper M, Heck AJ. Proteome analysis of yeast response to various nutrient limitations. Molecular Systems Biology. 2: 2006.0026. PMID 16738570 DOI: 10.1038/Msb4100069  0.322
2006 Eman MR, Regan-Klapisz E, Pinkse MW, Koop IM, Haverkamp J, Heck AJ, Verkleij AJ, Post JA. Protein expression dynamics during replicative senescence of endothelial cells studied by 2-D difference in-gel electrophoresis. Electrophoresis. 27: 1669-82. PMID 16609940 DOI: 10.1002/Elps.200500746  0.339
2006 Van Hoof D, Passier R, Ward-Van Oostwaard D, Pinkse MW, Heck AJ, Mummery CL, Krijgsveld J. A quest for human and mouse embryonic stem cell-specific proteins. Molecular & Cellular Proteomics : McP. 5: 1261-73. PMID 16600995 DOI: 10.1074/Mcp.M500405-Mcp200  0.359
2006 van Duijn E, Simmons DA, van den Heuvel RH, Bakkes PJ, van Heerikhuizen H, Heeren RM, Robinson CV, van der Vies SM, Heck AJ. Tandem mass spectrometry of intact GroEL-substrate complexes reveals substrate-specific conformational changes in the trans ring. Journal of the American Chemical Society. 128: 4694-702. PMID 16594706 DOI: 10.1021/Ja056756L  0.349
2006 Yatsuda AP, Bakker N, Krijgsveld J, Knox DP, Heck AJ, de Vries E. Identification of secreted cysteine proteases from the parasitic nematode Haemonchus contortus detected by biotinylated inhibitors. Infection and Immunity. 74: 1989-93. PMID 16495580 DOI: 10.1128/Iai.74.3.1989-1993.2006  0.32
2006 Meiring HD, Soethout EC, Poelen MC, Mooibroek D, Hoogerbrugge R, Timmermans H, Boog CJ, Heck AJ, de Jong AP, van Els CA. Stable isotope tagging of epitopes: a highly selective strategy for the identification of major histocompatibility complex class I-associated peptides induced upon viral infection. Molecular & Cellular Proteomics : McP. 5: 902-13. PMID 16432254 DOI: 10.1074/Mcp.T500014-Mcp200  0.321
2006 de Mol NJ, Catalina MI, Dekker FJ, Fischer MJ, Heck AJ, Liskamp RM. Protein flexibility and ligand rigidity: a thermodynamic and kinetic study of ITAM-based ligand binding to Syk tandem SH2. Chembiochem : a European Journal of Chemical Biology. 6: 2261-70. PMID 16252296 DOI: 10.1002/Cbic.200500141  0.32
2006 Heck AJ, Krijgsveld J. Mass spectrometry-based quantitative proteomics. Expert Review of Proteomics. 1: 317-26. PMID 15966828 DOI: 10.1586/14789450.1.3.317  0.392
2006 Catalina MI, van den Heuvel RH, van Duijn E, Heck AJ. Decharging of globular proteins and protein complexes in electrospray. Chemistry (Weinheim An Der Bergstrasse, Germany). 11: 960-8. PMID 15593239 DOI: 10.1002/Chem.200400395  0.386
2006 Kleinnijenhuis AJ, Mihalca R, Heeren RM, Heck AJ. Atypical behavior in the electron capture induced dissociation of biologically relevant transition metal ion complexes of the peptide hormone oxytocin International Journal of Mass Spectrometry. 253: 217-224. DOI: 10.1016/J.Ijms.2006.03.005  0.301
2005 Siebert HC, Born K, André S, Frank M, Kaltner H, von der Lieth CW, Heck AJ, Jiménez-Barbero J, Kopitz J, Gabius HJ. Carbohydrate chain of ganglioside GM1 as a ligand: identification of the binding strategies of three 15 mer peptides and their divergence from the binding modes of growth-regulatory galectin-1 and cholera toxin. Chemistry (Weinheim An Der Bergstrasse, Germany). 12: 388-402. PMID 16267866 DOI: 10.1002/Chem.200500505  0.347
2005 van der Veken P, Dirksen EH, Ruijter E, Elgersma RC, Heck AJ, Rijkers DT, Slijper M, Liskamp RM. Development of a novel chemical probe for the selective enrichment of phosphorylated serine- and threonine-containing peptides. Chembiochem : a European Journal of Chemical Biology. 6: 2271-80. PMID 16254931 DOI: 10.1002/Cbic.200500209  0.39
2005 Kruithof CA, Casado MA, Guillena G, Egmond MR, van der Kerk-van Hoof A, Heck AJ, Klein Gebbink RJ, van Koten G. Lipase active-site-directed anchoring of organometallics: metallopincer/protein hybrids. Chemistry (Weinheim An Der Bergstrasse, Germany). 11: 6869-77. PMID 16224766 DOI: 10.1002/Chem.200500671  0.317
2005 Kolkman A, Slijper M, Heck AJ. Development and application of proteomics technologies in Saccharomyces cerevisiae. Trends in Biotechnology. 23: 598-604. PMID 16202464 DOI: 10.1016/J.Tibtech.2005.09.004  0.379
2005 van den Heuvel RH, Tahallah N, Kamerbeek NM, Fraaije MW, van Berkel WJ, Janssen DB, Heck AJ. Coenzyme binding during catalysis is beneficial for the stability of 4-hydroxyacetophenone monooxygenase. The Journal of Biological Chemistry. 280: 32115-21. PMID 16049018 DOI: 10.1074/Jbc.M503758200  0.308
2005 Romijn EP, Christis C, Wieffer M, Gouw JW, Fullaondo A, van der Sluijs P, Braakman I, Heck AJ. Expression clustering reveals detailed co-expression patterns of functionally related proteins during B cell differentiation: a proteomic study using a combination of one-dimensional gel electrophoresis, LC-MS/MS, and stable isotope labeling by amino acids in cell culture (SILAC). Molecular & Cellular Proteomics : McP. 4: 1297-310. PMID 15961381 DOI: 10.1074/Mcp.M500123-Mcp200  0.371
2005 van den Heuvel RH, Gato S, Versluis C, Gerbaux P, Kleanthous C, Heck AJ. Real-time monitoring of enzymatic DNA hydrolysis by electrospray ionization mass spectrometry. Nucleic Acids Research. 33: e96. PMID 15956101 DOI: 10.1093/Nar/Gni099  0.335
2005 Catalina MI, Fischer MJ, Dekker FJ, Liskamp RM, Heck AJ. Binding of a diphosphorylated-ITAM peptide to spleen tyrosine kinase (Syk) induces distal conformational changes: a hydrogen exchange mass spectrometry study. Journal of the American Society For Mass Spectrometry. 16: 1039-51. PMID 15914019 DOI: 10.1016/J.Jasms.2005.02.011  0.403
2005 Brandon EF, van Ooijen RD, Sparidans RW, Lázaro LL, Heck AJ, Beijnen JH, Schellens JH. Structure elucidation of aplidine metabolites formed in vitro by human liver microsomes using triple quadrupole mass spectrometry. Journal of Mass Spectrometry : Jms. 40: 821-31. PMID 15892174 DOI: 10.1002/Jms.863  0.316
2005 van Duijn E, Bakkes PJ, Heeren RM, van den Heuvel RH, van Heerikhuizen H, van der Vies SM, Heck AJ. Monitoring macromolecular complexes involved in the chaperonin-assisted protein folding cycle by mass spectrometry. Nature Methods. 2: 371-6. PMID 15846365 DOI: 10.1038/Nmeth753  0.401
2005 Kolkman A, Dirksen EH, Slijper M, Heck AJ. Double standards in quantitative proteomics: direct comparative assessment of difference in gel electrophoresis and metabolic stable isotope labeling. Molecular & Cellular Proteomics : McP. 4: 255-66. PMID 15632418 DOI: 10.1074/Mcp.M400121-Mcp200  0.369
2005 André S, Kaltner H, Lensch M, Russwurm R, Siebert HC, Fallsehr C, Tajkhorshid E, Heck AJ, von Knebel Doeberitz M, Gabius HJ, Kopitz J. Determination of structural and functional overlap/divergence of five proto-type galectins by analysis of the growth-regulatory interaction with ganglioside GM1 in silico and in vitro on human neuroblastoma cells. International Journal of Cancer. Journal International Du Cancer. 114: 46-57. PMID 15523676 DOI: 10.1002/Ijc.20699  0.31
2005 van den Heuvel RH, Heck AJ. Native protein mass spectrometry: from intact oligomers to functional machineries. Current Opinion in Chemical Biology. 8: 519-26. PMID 15450495 DOI: 10.1016/J.Cbpa.2004.08.006  0.415
2005 Pinkse MW, Uitto PM, Hilhorst MJ, Ooms B, Heck AJ. Selective isolation at the femtomole level of phosphopeptides from proteolytic digests using 2D-NanoLC-ESI-MS/MS and titanium oxide precolumns. Analytical Chemistry. 76: 3935-43. PMID 15253627 DOI: 10.1021/Ac0498617  0.371
2004 Kolkman A, Olsthoorn MM, Heeremans CE, Heck AJ, Slijper M. Comparative proteome analysis of Saccharomyces cerevisiae grown in chemostat cultures limited for glucose or ethanol. Molecular & Cellular Proteomics : McP. 4: 1-11. PMID 15502163 DOI: 10.1074/Mcp.M400087-Mcp200  0.303
2004 Avram D, Romijn EP, Pap EH, Heck AJ, Wirtz KW. Identification of proteins in activated human neutrophils susceptible to tyrosyl radical attack. A proteomic study using a tyrosylating fluorophore. Proteomics. 4: 2397-407. PMID 15274135 DOI: 10.1002/Pmic.200300755  0.35
2004 Heck AJ, Van Den Heuvel RH. Investigation of intact protein complexes by mass spectrometry. Mass Spectrometry Reviews. 23: 368-89. PMID 15264235 DOI: 10.1002/Mas.10081  0.41
2004 de Mol NJ, Catalina MI, Fischer MJ, Broutin I, Maier CS, Heck AJ. Changes in structural dynamics of the Grb2 adaptor protein upon binding of phosphotyrosine ligand to its SH2 domain. Biochimica Et Biophysica Acta. 1700: 53-64. PMID 15210125 DOI: 10.1016/J.Bbapap.2004.03.016  0.356
2004 Bosch BJ, Martina BE, Van Der Zee R, Lepault J, Haijema BJ, Versluis C, Heck AJ, De Groot R, Osterhaus AD, Rottier PJ. Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides. Proceedings of the National Academy of Sciences of the United States of America. 101: 8455-60. PMID 15150417 DOI: 10.1073/Pnas.0400576101  0.311
2004 van den Bremer ET, Keeble AH, Jiskoot W, Spelbrink RE, Maier CS, van Hoek A, Visser AJ, James R, Moore GR, Kleanthous C, Heck AJ. Distinct conformational stability and functional activity of four highly homologous endonuclease colicins. Protein Science : a Publication of the Protein Society. 13: 1391-401. PMID 15096639 DOI: 10.1110/Ps.03508204  0.327
2004 Ridder AN, Spelbrink RE, Demmers JA, Rijkers DT, Liskamp RM, Brunner J, Heck AJ, de Kruijff B, Killian JA. Photo-crosslinking analysis of preferential interactions between a transmembrane peptide and matching lipids. Biochemistry. 43: 4482-9. PMID 15078094 DOI: 10.1021/Bi049899D  0.302
2004 Mohrmann L, Langenberg K, Krijgsveld J, Kal AJ, Heck AJ, Verrijzer CP. Differential targeting of two distinct SWI/SNF-related Drosophila chromatin-remodeling complexes. Molecular and Cellular Biology. 24: 3077-88. PMID 15060132 DOI: 10.1128/Mcb.24.8.3077-3088.2004  0.32
2004 Stokvis E, Rosing H, Crul M, Rieser MJ, Heck AJ, Schellens JH, Beijnen JH. Quantitative analysis of the novel anticancer drug ABT-518, a matrix metalloproteinase inhibitor, plus the screening of six metabolites in human plasma using high-performance liquid chromatography coupled with electrospray tandem mass spectrometry. Journal of Mass Spectrometry : Jms. 39: 277-88. PMID 15039935 DOI: 10.1002/Jms.579  0.303
2004 van den Heuvel RH, Westphal AH, Heck AJ, Walsh MA, Rovida S, van Berkel WJ, Mattevi A. Structural studies on flavin reductase PheA2 reveal binding of NAD in an unusual folded conformation and support novel mechanism of action. The Journal of Biological Chemistry. 279: 12860-7. PMID 14703520 DOI: 10.1074/Jbc.M313765200  0.311
2004 Houtman R, Krijgsveld J, Kool M, Romijn EP, Redegeld FA, Nijkamp FP, Heck AJ, Humphery-Smith I. Lung proteome alterations in a mouse model for nonallergic asthma. Proteomics. 3: 2008-18. PMID 14625863 DOI: 10.1002/Pmic.200300469  0.306
2004 Heck AJ, Jørgensen TJ. Vancomycin in vacuo International Journal of Mass Spectrometry. 236: 11-23. DOI: 10.1016/J.Ijms.2004.05.006  0.352
2003 Kleinnijenhuis AJ, Duursma MC, Breukink E, Heeren RM, Heck AJ. Localization of intramolecular monosulfide bridges in lantibiotics determined with electron capture induced dissociation. Analytical Chemistry. 75: 3219-25. PMID 12964772 DOI: 10.1021/Ac0263770  0.319
2003 Romijn EP, Krijgsveld J, Heck AJ. Recent liquid chromatographic-(tandem) mass spectrometric applications in proteomics. Journal of Chromatography. A. 1000: 589-608. PMID 12877191 DOI: 10.1016/S0021-9673(03)00178-X  0.364
2003 Krijgsveld J, Ketting RF, Mahmoudi T, Johansen J, Artal-Sanz M, Verrijzer CP, Plasterk RH, Heck AJ. Metabolic labeling of C. elegans and D. melanogaster for quantitative proteomics. Nature Biotechnology. 21: 927-31. PMID 12858183 DOI: 10.1038/Nbt848  0.362
2003 de Boer E, Rodriguez P, Bonte E, Krijgsveld J, Katsantoni E, Heck A, Grosveld F, Strouboulis J. Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 7480-5. PMID 12802011 DOI: 10.1073/Pnas.1332608100  0.363
2003 van Anken E, Romijn EP, Maggioni C, Mezghrani A, Sitia R, Braakman I, Heck AJ. Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretion. Immunity. 18: 243-53. PMID 12594951 DOI: 10.1016/S1074-7613(03)00024-4  0.307
2003 Yatsuda AP, Krijgsveld J, Cornelissen AW, Heck AJ, de Vries E. Comprehensive analysis of the secreted proteins of the parasite Haemonchus contortus reveals extensive sequence variation and differential immune recognition. The Journal of Biological Chemistry. 278: 16941-51. PMID 12576473 DOI: 10.1074/Jbc.M212453200  0.373
2002 Demmers JA, Rijkers DT, Haverkamp J, Killian JA, Heck AJ. Factors affecting gas-phase deuterium scrambling in peptide ions and their implications for protein structure determination. Journal of the American Chemical Society. 124: 11191-8. PMID 12224967 DOI: 10.1021/Ja0125927  0.378
2002 Jerić I, Versluis C, Horvat S, Heck AJ. Tracing glycoprotein structures: electrospray ionization tandem mass spectrometric analysis of sugar-peptide adducts. Journal of Mass Spectrometry : Jms. 37: 803-11. PMID 12203674 DOI: 10.1002/Jms.337  0.35
2002 Bossi RT, Aliverti A, Raimondi D, Fischer F, Zanetti G, Ferrari D, Tahallah N, Maier CS, Heck AJ, Rizzi M, Mattevi A. A covalent modification of NADP+ revealed by the atomic resolution structure of FprA, a Mycobacterium tuberculosis oxidoreductase. Biochemistry. 41: 8807-18. PMID 12102623 DOI: 10.1021/Bi025858A  0.313
2002 van den Bremer ET, Jiskoot W, James R, Moore GR, Kleanthous C, Heck AJ, Maier CS. Probing metal ion binding and conformational properties of the colicin E9 endonuclease by electrospray ionization time-of-flight mass spectrometry. Protein Science : a Publication of the Protein Society. 11: 1738-52. PMID 12070327 DOI: 10.1110/Ps.0200502  0.333
2002 Vollmerhaus PJ, Tempels FW, Kettenes-van den Bosch JJ, Heck AJ. Molecular interactions of glycopeptide antibiotics investigated by affinity capillary electrophoresis and bioaffinity electrospray ionization-mass spectrometry. Electrophoresis. 23: 868-79. PMID 11920871 DOI: 10.1002/1522-2683(200203)23:6<868::Aid-Elps868>3.0.Co;2-#  0.354
2002 Ruijtenbeek R, Versluis C, Heck AJ, Redegeld FA, Nijkamp FP, Liskamp RM. Characterization of a phosphorylated peptide and peptoid and peptoid-peptide hybrids by mass spectrometry. Journal of Mass Spectrometry : Jms. 37: 47-55. PMID 11813310 DOI: 10.1002/Jms.245  0.365
2002 Waterval JC, Bestebreurtje P, Lingeman H, Versluis C, Heck AJ, Bult A, Underberg WJ. Robust and cost-effective capillary electrophoresis-mass spectrometry interfaces suitable for combination with on-line analyte preconcentration. Electrophoresis. 22: 2701-8. PMID 11545395 DOI: 10.1002/1522-2683(200108)22:13<2701::Aid-Elps2701>3.0.Co;2-3  0.311
2001 Demmers JA, van Duijn E, Haverkamp J, Greathouse DV, Koeppe RE, Heck AJ, Killian JA. Interfacial positioning and stability of transmembrane peptides in lipid bilayers studied by combining hydrogen/deuterium exchange and mass spectrometry. The Journal of Biological Chemistry. 276: 34501-8. PMID 11435420 DOI: 10.1074/Jbc.M101401200  0.34
2001 Roscić M, Versluis C, Kleinnijenhuis AJ, Horvat S, Heck AJ. The early glycation products of the Maillard reaction: mass spectrometric characterization of novel imidazolidinones derived from an opioid pentapeptide and glucose. Rapid Communications in Mass Spectrometry : Rcm. 15: 1022-9. PMID 11400213 DOI: 10.1002/Rcm.334  0.341
2001 Tahallah N, Pinkse M, Maier CS, Heck AJ. The effect of the source pressure on the abundance of ions of noncovalent protein assemblies in an electrospray ionization orthogonal time-of-flight instrument. Rapid Communications in Mass Spectrometry : Rcm. 15: 596-601. PMID 11312509 DOI: 10.1002/Rcm.275  0.313
2001 Heck AJ, Bonnici PJ, Breukink E, Morris D, Wills M. Modification and inhibition of vancomycin group antibiotics by formaldehyde and acetaldehyde. Chemistry (Weinheim An Der Bergstrasse, Germany). 7: 910-6. PMID 11288883 DOI: 10.1002/1521-3765(20010216)7:4<910::Aid-Chem910>3.0.Co;2-U  0.307
2001 Versluis C, van der Staaij A, Stokvis E, Heck AJ, de Craene B. Metastable ion formation and disparate charge separation in the gas-phase dissection of protein assemblies studied by orthogonal time-of-flight mass spectrometry. Journal of the American Society For Mass Spectrometry. 12: 329-36. PMID 11281608 DOI: 10.1016/S1044-0305(00)00227-0  0.355
2000 Stokvis E, Clugston SL, Honek JF, Heck AJ. Characterization of glyoxalase I (E. coli)-inhibitor interactions by electrospray time-of-flight mass spectrometry and enzyme kinetic analysis. Journal of Protein Chemistry. 19: 389-97. PMID 11212839 DOI: 10.1023/A:1026439531005  0.323
2000 van Berkel WJ, van den Heuvel RH, Versluis C, Heck AJ. Detection of intact megaDalton protein assemblies of vanillyl-alcohol oxidase by mass spectrometry. Protein Science : a Publication of the Protein Society. 9: 435-9. PMID 10752605 DOI: 10.1110/Ps.9.3.435  0.387
2000 Staroske T, O'Brien DP, Jørgensen TJ, Roepstorff P, Williams DH, Heck AJ. The formation of heterodimers by vancomycin group antibiotics. Chemistry (Weinheim An Der Bergstrasse, Germany). 6: 504-9. PMID 10747417 DOI: 10.1002/(Sici)1521-3765(20000204)6:3<504::Aid-Chem504>3.0.Co;2-5  0.318
2000 van der Kerk-van Hoof A, Heck AJ. Covalent and non-covalent dissociations of gas-phase complexes of avoparcin and bacterial receptor mimicking precursor peptides studied by collisionally activated decomposition mass spectrometry. Journal of Mass Spectrometry : Jms. 34: 813-9. PMID 10423562 DOI: 10.1002/(Sici)1096-9888(199908)34:8<813::Aid-Jms836>3.0.Co;2-7  0.323
1999 Lafitte D, Heck AJ, Hill TJ, Jumel K, Harding SE, Derrick PJ. Evidence of noncovalent dimerization of calmodulin. European Journal of Biochemistry / Febs. 261: 337-44. PMID 10103067 DOI: 10.1046/J.1432-1327.1999.00284.X  0.36
1998 Lavanant, H, Heck A, Derrick P, Mellon F, Parr A, Dodd H, Giffard C, Horn N, Gasson M. Characterisation of genetically modified nisin molecules by Fourier transform ion cyclotron resonance mass spectrometry European Journal of Mass Spectrometry. 4: 405. DOI: 10.1255/Ejms.240  0.34
1997 Rafferty TL, Gallagher RT, Derrick PJ, Heck AJ, Duncan A, Robins SP. Low- and high-energy collision-induced dissociation of pyridinoline and deoxypyridinoline ions using Fourier transform ion cyclotron resonance electrospray and liquid secondary-ion magnetic sector mass spectrometry International Journal of Mass Spectrometry and Ion Processes. 160: 377-386. DOI: 10.1016/S0168-1176(96)04486-2  0.308
1995 Heck AJ, Nibbering NM. Gas phase bimolecular chemistry of isomeric C3H 6Br (+) cations. Journal of the American Society For Mass Spectrometry. 6: 11-8. PMID 24222056 DOI: 10.1016/1044-0305(94)00084-D  0.656
1992 Heck AJ, de Koning LJ, Nibbering NM. Chemical behavior of the gas-phase pentacoordinated carbonium ion, C2H+7 International Journal of Mass Spectrometry and Ion Processes. 117: 145-169. DOI: 10.1016/0168-1176(92)80091-E  0.639
1991 Heck AJ, de Koning LJ, Nibbering NM. On the structure of protonated methane. Journal of the American Society For Mass Spectrometry. 2: 453-8. PMID 24242765 DOI: 10.1016/1044-0305(91)80030-B  0.641
1991 Heck AJ, de Koning LJ, Nibbering NM. On the structure and unimolecular chemistry of protonated halomethanes International Journal of Mass Spectrometry and Ion Processes. 109: 209-225. DOI: 10.1016/0168-1176(91)85105-U  0.63
1991 Drewello T, Heck AJ, Nibbering NM. Electron-capture-induced decomposition of the supposed ethane dication Chemical Physics Letters. 178: 285-288. DOI: 10.1016/0009-2614(91)87070-R  0.648
1990 Heck AJ, Drewello T, De Koning LJ, Nibbering NM. Low pressure ion/molecule clustering reactions towards cationic dimers International Journal of Mass Spectrometry and Ion Processes. 100: 611-624. DOI: 10.1016/0168-1176(90)85098-M  0.647
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