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Li Niu, Ph.D. - Publications

Affiliations: 
State University of New York, Albany, Albany, NY, United States 
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53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Akamatsu M, Yamashita T, Teramoto S, Huang Z, Lynch J, Toda T, Niu L, Kwak S. Testing of the therapeutic efficacy and safety of AMPA receptor RNA aptamers in an ALS mouse model. Life Science Alliance. 5. PMID 35022247 DOI: 10.26508/lsa.202101193  0.307
2021 Huang Z, Niu L. RNA aptamers for AMPA receptors. Neuropharmacology. 108761. PMID 34509496 DOI: 10.1016/j.neuropharm.2021.108761  0.362
2020 Jaremko W, Huang Z, Karl N, Pierce VD, Lynch J, Niu L. A kainate receptor-selective RNA aptamer. The Journal of Biological Chemistry. PMID 32161119 DOI: 10.1074/Jbc.Ra119.011649  0.542
2019 Pierce VD, Niu L. Stargazin and γ4 slow the channel opening and closing rates of GluA4 AMPA receptors. Scientific Reports. 9: 9570. PMID 31267004 DOI: 10.1038/S41598-019-45870-0  0.457
2017 Wen W, Lin CY, Niu L. R/G editing in GluA2Rflop modulates the functional difference between GluA1 flip and flop variants in GluA1/2R heteromeric channels. Scientific Reports. 7: 13654. PMID 29057893 DOI: 10.1038/S41598-017-13233-2  0.426
2017 Huang Z, Wen W, Wu A, Niu L. Chemically Modified, α-Amino-3-hydroxy-5-methyl-4-isoxazole (AMPA) Receptor RNA Aptamers Designed for in Vivo Use. Acs Chemical Neuroscience. PMID 28872832 DOI: 10.1021/Acschemneuro.7B00211  0.536
2017 Jaremko WJ, Huang Z, Wen W, Wu A, Karl N, Niu L. One aptamer, two functions: the full-length aptamer inhibits AMPA receptors, while the short one inhibits both AMPA and kainate receptors. Rna & Disease (Houston, Tex.). 4. PMID 28804757 DOI: 10.14800/Rd.1560  0.542
2017 Huang Z, Kangovi GN, Wen W, Lee S, Niu L. An RNA Aptamer Capable of Forming Hydrogel by Self-Assembly. Biomacromolecules. PMID 28609610 DOI: 10.1021/Acs.Biomac.7B00314  0.308
2017 Espahbodinia M, Ettari R, Wen W, Wu A, Shen YC, Niu L, Grasso S, Zappalà M. Development of novel N-3-bromoisoxazolin-5-yl substituted 2,3-benzodiazepines as noncompetitive AMPAR antagonists. Bioorganic & Medicinal Chemistry. PMID 28571973 DOI: 10.1016/J.Bmc.2017.05.036  0.411
2017 Jaremko WJ, Huang Z, Wen W, Wu A, Karl N, Niu L. Identification and Characterization of RNA Aptamers: A Long Aptamer Blocks the AMPA Receptor and a Short Aptamer Blocks Both AMPA and Kainate Receptors. The Journal of Biological Chemistry. PMID 28325839 DOI: 10.1074/Jbc.M116.774752  0.561
2017 Han Y, Lin CY, Niu L. Functional Roles of the Edited Isoform of GluA2 in GluA2-Containing AMPA Receptor Channels. Biochemistry. PMID 28244309 DOI: 10.1021/Acs.Biochem.6B01041  0.522
2015 Niu L. Mechanism-based design of 2,3-benzodiazepine inhibitors for AMPA receptors. Acta Pharmaceutica Sinica. B. 5: 500-5. PMID 26713266 DOI: 10.1016/j.apsb.2015.07.007  0.383
2015 Zhang ZZ, Wang CJ, Niu L, Xu J, Wang M, Cao H, Hu B. Analysis of plasma MicroRNAs to identifying early diagnostic molecule for gastric cancer. International Journal of Clinical and Experimental Medicine. 8: 3700-6. PMID 26064265  0.375
2015 Wang C, Wu A, Shen YC, Ettari R, Grasso S, Niu L. Mechanism and Site of Inhibition of AMPA Receptors: Substitution of One and Two Methyl Groups at the 4-Aminophenyl Ring of 2,3-Benzodiazepine and Implications in the "E" Site. Acs Chemical Neuroscience. PMID 25967651 DOI: 10.1021/Acschemneuro.5B00064  0.578
2015 Lin CY, Huang Z, Wen W, Wu A, Wang C, Niu L. Enhancing Protein Expression in HEK-293 Cells by Lowering Culture Temperature. Plos One. 10: e0123562. PMID 25893827 DOI: 10.1371/Journal.Pone.0123562  0.53
2014 Wu A, Wang C, Niu L. Mechanism of inhibition of the GluA1 AMPA receptor channel opening by the 2,3-benzodiazepine compound GYKI 52466 and a N-methyl-carbamoyl derivative. Biochemistry. 53: 3033-41. PMID 24738995 DOI: 10.1021/Bi5002079  0.659
2014 Wang C, Han Y, Wu A, Sólyom S, Niu L. Mechanism and site of inhibition of AMPA receptors: pairing a thiadiazole with a 2,3-benzodiazepine scaffold. Acs Chemical Neuroscience. 5: 138-47. PMID 24313227 DOI: 10.1021/Cn400193U  0.695
2013 Wang C, Niu L. Mechanism of inhibition of the GluA2 AMPA receptor channel opening by talampanel and its enantiomer: the stereochemistry of the 4-methyl group on the diazepine ring of 2,3-benzodiazepine derivatives. Acs Chemical Neuroscience. 4: 635-44. PMID 23402301 DOI: 10.1021/Cn3002398  0.68
2013 Huang Z, Jayaseelan S, Hebert J, Seo H, Niu L. Single-nucleotide resolution of RNAs up to 59 nucleotides by high-performance liquid chromatography. Analytical Biochemistry. 435: 35-43. PMID 23274387 DOI: 10.1016/J.Ab.2012.12.011  0.679
2012 Qneibi MS, Micale N, Grasso S, Niu L. Mechanism of inhibition of GluA2 AMPA receptor channel opening by 2,3-benzodiazepine derivatives: functional consequences of replacing a 7,8-methylenedioxy with a 7,8-ethylenedioxy moiety. Biochemistry. 51: 1787-95. PMID 22304561 DOI: 10.1021/Bi2017552  0.811
2012 Han Y, Wang C, Park JS, Niu L. Channel-opening kinetic mechanism of wild-type GluK1 kainate receptors and a C-terminal mutant. Biochemistry. 51: 761-8. PMID 22191429 DOI: 10.1021/Bi201446Z  0.647
2012 Wang C, Niu L. Mechanism of Inhibition of the GluA2 AMPA Receptor Channel Opening by 2,3-Benzodiazepine Derivatives Biophysical Journal. 102: 116a. DOI: 10.1016/J.Bpj.2011.11.652  0.69
2011 Ritz M, Wang C, Micale N, Ettari R, Niu L. Mechanism of Inhibition of the GluA2 AMPA Receptor Channel Opening: the Role of 4-Methyl versus 4-Carbonyl Group on the Diazepine Ring of 2,3-Benzodiazepine Derivatives. Acs Chemical Neuroscience. 2: 506-513. PMID 22059113 DOI: 10.1021/Cn200033J  0.703
2011 Wang C, Sheng Z, Niu L. Mechanism of inhibition of the GluA2 AMPA receptor channel opening: consequences of adding an N-3 methylcarbamoyl group to the diazepine ring of 2,3-benzodiazepine derivatives. Biochemistry. 50: 7284-93. PMID 21751782 DOI: 10.1021/Bi2007977  0.654
2011 Park JS, Wang C, Han Y, Huang Z, Niu L. Potent and selective inhibition of a single alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit by an RNA aptamer. The Journal of Biological Chemistry. 286: 15608-17. PMID 21402710 DOI: 10.1074/Jbc.M111.229559  0.699
2010 Han Y, Wang C, Park JS, Niu L. Channel-opening kinetic mechanism for human wild-type GluK2 and the M867I mutant kainate receptor. Biochemistry. 49: 9207-16. PMID 20863077 DOI: 10.1016/J.Bpj.2010.12.1674  0.645
2010 Huang Z, Han Y, Wang C, Niu L. Potent and selective inhibition of the open-channel conformation of AMPA receptors by an RNA aptamer. Biochemistry. 49: 5790-8. PMID 20518485 DOI: 10.1016/J.Bpj.2010.12.1678  0.689
2010 Huang Z, Seon Park J, Pei W, Han Y, Jayaseelan S, Niu L. Development of AMPA Receptor Aptamers Biophysical Journal. 98: 526a. DOI: 10.1016/J.Bpj.2009.12.2856  0.816
2009 Huang Z, Pei W, Han Y, Jayaseelan S, Shekhtman A, Shi H, Niu L. One RNA aptamer sequence, two structures: a collaborating pair that inhibits AMPA receptors. Nucleic Acids Research. 37: 4022-32. PMID 19417060 DOI: 10.1016/J.Bpj.2008.12.3029  0.757
2009 Pei W, Huang Z, Wang C, Han Y, Park JS, Niu L. Flip and flop: a molecular determinant for AMPA receptor channel opening. Biochemistry. 48: 3767-77. PMID 19275243 DOI: 10.1021/Bi8015907  0.725
2009 Jayaseelan S, Huang Z, Theimer C, Niu L. UV Melting and Footprinting Studies of Three Structures of an RNA Aptamer with the Same Sequence Biophysical Journal. 96: 579a. DOI: 10.1016/J.Bpj.2008.12.3028  0.712
2008 Ritz M, Micale N, Grasso S, Niu L. Mechanism of inhibition of the GluR2 AMPA receptor channel opening by 2,3-benzodiazepine derivatives Biochemistry. 47: 1061-1069. PMID 18161947 DOI: 10.1021/Bi700782X  0.588
2007 Huang Z, Pei W, Jayaseelan S, Shi H, Niu L. RNA aptamers selected against the GluR2 glutamate receptor channel. Biochemistry. 46: 12648-55. PMID 17929944 DOI: 10.1021/Bi701036P  0.82
2007 Pei W, Ritz M, McCarthy M, Huang Z, Niu L. Receptor occupancy and channel-opening kinetics: a study of GLUR1 L497Y AMPA receptor. The Journal of Biological Chemistry. 282: 22731-6. PMID 17545169 DOI: 10.1074/Jbc.M611821200  0.686
2007 Kornreich BG, Niu L, Roberson MS, Oswald RE. Identification of C-terminal domain residues involved in protein kinase A-mediated potentiation of kainate receptor subtype 6. Neuroscience. 146: 1158-68. PMID 17379418 DOI: 10.1016/J.Neuroscience.2007.02.012  0.369
2007 Pei W, Huang Z, Niu L. GluR3 flip and flop: differences in channel opening kinetics. Biochemistry. 46: 2027-36. PMID 17256974 DOI: 10.1021/Bi062213S  0.691
2005 Li G, Sheng Z, Huang Z, Niu L. Kinetic mechanism of channel opening of the GluRDflip AMPA receptor Biochemistry. 44: 5835-5841. PMID 15823042 DOI: 10.1021/Bi047413N  0.568
2005 Huang Z, Li G, Pei W, Sosa LA, Niu L. Enhancing protein expression in single HEK 293 cells. Journal of Neuroscience Methods. 142: 159-66. PMID 15652630 DOI: 10.1016/J.Jneumeth.2004.09.009  0.554
2004 Li G, Niu L. How Fast Does the GluR1Qflip Channel Open? Journal of Biological Chemistry. 279: 3990-3997. PMID 14610080 DOI: 10.1074/jbc.M310410200  0.429
2003 Li G, Oswald RE, Niu L. Channel-opening kinetics of GluR6 kainate receptor. Biochemistry. 42: 12367-75. PMID 14567698 DOI: 10.1021/Bi034797T  0.538
2003 Li G, Pei W, Niu L. Channel-Opening Kinetics of GluR2Qflip AMPA Receptor: A Laser-Pulse Photolysis Study Biochemistry. 42: 12358-12366. PMID 14567697 DOI: 10.1021/Bi0347961  0.689
2000 Hess GP, Ulrich H, Breitinger HG, Niu L, Gameiro AM, Grewer C, Srivastava S, Ippolito JE, Lee SM, Jayaraman V, Coombs SE. Mechanism-based discovery of ligands that counteract inhibition of the nicotinic acetylcholine receptor by cocaine and MK-801. Proceedings of the National Academy of Sciences of the United States of America. 97: 13895-900. PMID 11095713 DOI: 10.1073/Pnas.240459497  0.776
1999 Gee KR, Niu L, Schaper K, Jayaraman V, Hess GP. Synthesis and photochemistry of a photolabile precursor of N-methyl-D-aspartate (NMDA) that is photolyzed in the microsecond time region and is suitable for chemical kinetic investigations of the NMDA receptor. Biochemistry. 38: 3140-7. PMID 10074369 DOI: 10.1021/Bi9826557  0.801
1996 Niu L, Vazquez RW, Nagel G, Friedrich T, Bamberg E, Oswald RE, Hess GP. Rapid chemical kinetic techniques for investigations of neurotransmitter receptors expressed in Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. 93: 12964-8. PMID 8917527 DOI: 10.1073/Pnas.93.23.12964  0.662
1996 Niu L, Wieboldt R, Ramesh D, Carpenter BK, Hess GP. Synthesis and characterization of a caged receptor ligand suitable for chemical kinetic investigations of the glycine receptor in the 3-microseconds time domain. Biochemistry. 35: 8136-42. PMID 8679565 DOI: 10.1021/Bi952364N  0.788
1996 Niu L, Gee KR, Schaper K, Hess GP. Synthesis and photochemical properties of a kainate precursor and activation of kainate and AMPA receptor channels on a microsecond time scale. Biochemistry. 35: 2030-6. PMID 8639688 DOI: 10.1021/Bi9516485  0.793
1996 Niu L, Grewer C, Hess GP. Chemical kinetic investigations of neurotransmitter receptors on a cell Surface in the μs time region Techniques in Protein Chemistry. 7: 139-149. DOI: 10.1016/S1080-8914(96)80018-4  0.785
1995 Niu L, Abood LG, Hess GP. Cocaine: mechanism of inhibition of a muscle acetylcholine receptor studied by a laser-pulse photolysis technique. Proceedings of the National Academy of Sciences of the United States of America. 92: 12008-12. PMID 8618833 DOI: 10.1073/Pnas.92.26.12008  0.644
1995 Hess GP, Niu L, Wieboldt R. Determination of the chemical mechanism of neurotransmitter receptor-mediated reactions by rapid chemical kinetic methods. Annals of the New York Academy of Sciences. 757: 23-39. PMID 7611678 DOI: 10.1111/J.1749-6632.1995.Tb17462.X  0.78
1995 Gee KR, Niu L, Schaper K, Hess GP. Caged bioactive carboxylates. Synthesis, photolysis studies, and biological characterization of a new caged N-methyl-D-aspartic acid Journal of Organic Chemistry. 60: 4260-4263. DOI: 10.1021/Jo00118A050  0.653
1994 Wieboldt R, Gee KR, Niu L, Ramesh D, Carpenter BK, Hess GP. Photolabile precursors of glutamate: synthesis, photochemical properties, and activation of glutamate receptors on a microsecond time scale. Proceedings of the National Academy of Sciences of the United States of America. 91: 8752-6. PMID 8090718 DOI: 10.1073/Pnas.91.19.8752  0.782
1993 Niu L, Hess GP. An acetylcholine receptor regulatory site in BC3H1 cells: characterized by laser-pulse photolysis in the microsecond-to-millisecond time region. Biochemistry. 32: 3831-5. PMID 8471597 DOI: 10.1021/Bi00066A001  0.671
1993 Ramesh D, Wieboldt R, Niu L, Carpenter BK, Hess GP. Photolysis of a protecting group for the carboxyl function of neurotransmitters within 3 microseconds and with product quantum yield of 0.2. Proceedings of the National Academy of Sciences of the United States of America. 90: 11074-8. PMID 7902580 DOI: 10.1073/Pnas.90.23.11074  0.794
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