| Year |
Citation |
Score |
| 2023 |
Cui A, Huang T, Li S, Ma A, Pérez JL, Sander C, Keskin DB, Wu CJ, Fraenkel E, Hacohen N. Dictionary of immune responses to cytokines at single-cell resolution. Nature. PMID 38057668 DOI: 10.1038/s41586-023-06816-9 |
0.305 |
|
| 2023 |
Reyes M, Leff SM, Gentili M, Hacohen N, Blainey PC. Microscale combinatorial stimulation of human myeloid cells reveals inflammatory priming by viral ligands. Science Advances. 9: eade5090. PMID 36827376 DOI: 10.1126/sciadv.ade5090 |
0.305 |
|
| 2023 |
Gentili M, Liu B, Papanastasiou M, Dele-Oni D, Schwartz MA, Carlson RJ, Al'Khafaji AM, Krug K, Brown A, Doench JG, Carr SA, Hacohen N. ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling. Nature Communications. 14: 611. PMID 36739287 DOI: 10.1038/s41467-023-36132-9 |
0.305 |
|
| 2022 |
Chao S, Brenner MP, Hacohen N. Identifying Cell Type-Specific Chemokine Correlates with Hierarchical Signal Extraction from Single-Cell Transcriptomes. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 27: 254-265. PMID 34890154 |
0.3 |
|
| 2021 |
Chen J, Pelka K, Hofree M, Giannakis M, Boland G, Aguirre A, Anderson A, Rozenblatt-Rosen O, Regev A, Hacohen N. 641 Spatially organized multicellular immune hubs in MMRd and MMRp colorectal cancer Journal For Immunotherapy of Cancer. 9: A670-A670. DOI: 10.1136/jitc-2021-sitc2021.641 |
0.301 |
|
| 2020 |
Chia BS, Li B, Cui A, Eisenhaure T, Raychowdhury R, Lieb D, Hacohen N. Loss of the nuclear protein RTF2 enhances influenza replication. Journal of Virology. PMID 32878895 DOI: 10.1128/Jvi.00319-20 |
0.349 |
|
| 2020 |
Johnstone SE, Reyes A, Qi Y, Adriaens C, Hegazi E, Pelka K, Chen JH, Zou LS, Drier Y, Hecht V, Shoresh N, Selig MK, Lareau CA, Iyer S, Nguyen SC, ... ... Hacohen N, et al. Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer. Cell. PMID 32841603 DOI: 10.1016/J.Cell.2020.07.030 |
0.332 |
|
| 2020 |
Lareau CA, Ludwig LS, Muus C, Gohil SH, Zhao T, Chiang Z, Pelka K, Verboon JM, Luo W, Christian E, Rosebrock D, Getz G, Boland GM, Chen F, Buenrostro JD, ... Hacohen N, et al. Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling. Nature Biotechnology. PMID 32788668 DOI: 10.1038/S41587-020-0645-6 |
0.366 |
|
| 2020 |
Li B, Gould J, Yang Y, Sarkizova S, Tabaka M, Ashenberg O, Rosen Y, Slyper M, Kowalczyk MS, Villani AC, Tickle T, Hacohen N, Rozenblatt-Rosen O, Regev A. Cumulus provides cloud-based data analysis for large-scale single-cell and single-nucleus RNA-seq. Nature Methods. PMID 32719530 DOI: 10.1038/S41592-020-0905-X |
0.335 |
|
| 2020 |
Marigo I, Trovato R, Hofer F, Ingangi V, DE Sanctis F, Ugel S, Cane S, Simonelli A, Lamolinara A, Iezzi M, Fassan M, Rugge M, Boschi F, Borile G, Eisenhaure T, ... ... Hacohen N, et al. The Disabled homolog 2 controls pro-metastatic activity of tumor-associated macrophages. Cancer Discovery. PMID 32651166 DOI: 10.1158/2159-8290.Cd-20-0036 |
0.308 |
|
| 2020 |
de Boer CG, Ray JP, Hacohen N, Regev A. MAUDE: inferring expression changes in sorting-based CRISPR screens. Genome Biology. 21: 134. PMID 32493396 DOI: 10.1186/S13059-020-02046-8 |
0.332 |
|
| 2020 |
Fava A, Buyon JP, Mohan C, Zhang T, Belmont HM, Izmirly P, Clancy R, Monroy Trujillo J, Fine DM, Zhang Y, Magder L, Rao DA, Arazi A, Berthier CC, Davidson A, ... ... Hacohen N, et al. Integrated urine proteomics and renal single-cell genomics identify an interferon-γ response gradient in lupus nephritis. Jci Insight. PMID 32396533 DOI: 10.1172/Jci.Insight.138345 |
0.372 |
|
| 2020 |
Ding J, Adiconis X, Simmons SK, Kowalczyk MS, Hession CC, Marjanovic ND, Hughes TK, Wadsworth MH, Burks T, Nguyen LT, Kwon JYH, Barak B, Ge W, Kedaigle AJ, Carroll S, ... ... Hacohen N, et al. Systematic comparison of single-cell and single-nucleus RNA-sequencing methods. Nature Biotechnology. PMID 32341560 DOI: 10.1038/S41587-020-0465-8 |
0.328 |
|
| 2020 |
Ray JP, de Boer CG, Fulco CP, Lareau CA, Kanai M, Ulirsch JC, Tewhey R, Ludwig LS, Reilly SK, Bergman DT, Engreitz JM, Issner R, Finucane HK, Lander ES, Regev A, ... Hacohen N, et al. Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features. Nature Communications. 11: 1237. PMID 32144282 DOI: 10.1038/S41467-020-15022-4 |
0.3 |
|
| 2020 |
Hajaj E, Eisenberg G, Klein S, Frankenburg S, Merims S, Ben David I, Eisenhaure T, Henrickson SE, Villani AC, Hacohen N, Abudi N, Abramovich R, Cohen JE, Peretz T, Veillette A, et al. SLAMF6 deficiency augments tumor killing and skews towards an effector phenotype revealing it as a novel T cell checkpoint. Elife. 9. PMID 32122464 DOI: 10.7554/Elife.52539 |
0.365 |
|
| 2020 |
Menon R, Otto EA, Hoover PJ, Eddy S, Mariani LH, Godfrey B, Berthier CC, Eichinger F, Subramanian L, Harder JL, Ju W, Nair V, Larkina M, Naik AS, Luo J, ... ... Hacohen N, et al. Single cell transcriptomics identifies focal segmental glomerulosclerosis remission endothelial biomarker. Jci Insight. PMID 32107344 DOI: 10.1172/Jci.Insight.133267 |
0.378 |
|
| 2020 |
Reyes M, Filbin MR, Bhattacharyya RP, Billman K, Eisenhaure T, Hung DT, Levy BD, Baron RM, Blainey PC, Goldberg MB, Hacohen N. An immune-cell signature of bacterial sepsis. Nature Medicine. PMID 32066974 DOI: 10.1038/S41591-020-0752-4 |
0.429 |
|
| 2020 |
Helmink BA, Reddy SM, Gao J, Zhang S, Basar R, Thakur R, Yizhak K, Sade-Feldman M, Blando J, Han G, Gopalakrishnan V, Xi Y, Zhao H, Amaria RN, Tawbi HA, ... ... Hacohen N, et al. B cells and tertiary lymphoid structures promote immunotherapy response. Nature. PMID 31942075 DOI: 10.1038/S41586-019-1922-8 |
0.419 |
|
| 2020 |
Li B, Clohisey SM, Chia BS, Wang B, Cui A, Eisenhaure T, Schweitzer LD, Hoover P, Parkinson NJ, Nachshon A, Smith N, Regan T, Farr D, Gutmann MU, Bukhari SI, ... ... Hacohen N, et al. Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection. Nature Communications. 11: 164. PMID 31919360 DOI: 10.1038/S41467-019-13965-X |
0.321 |
|
| 2020 |
Hajaj E, Eisenberg G, Klein S, Frankenburg S, Merims S, David IB, Eisenhaure T, Henrickson SE, Villani AC, Hacohen N, Abudi N, Abramovich R, Cohen JE, Peretz T, Veillette A, et al. Author response: SLAMF6 deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint Elife. DOI: 10.7554/Elife.52539.Sa2 |
0.347 |
|
| 2020 |
Blum SM, Smith N, Sade-Feldman M, Frederick DT, Jenkins RW, Cohen JV, Lawrence DP, Mooradian M, Freedman C, Fadden R, Rubin KM, Richey S, Flaherty K, Wargo JA, Hacohen N, et al. Investigating the tumor immune infiltrate for populations that predict immune-related adverse events (irAEs) in patients receiving PD-1 inhibitors. Journal of Clinical Oncology. 38: 3116-3116. DOI: 10.1200/Jco.2020.38.15_Suppl.3116 |
0.301 |
|
| 2020 |
Mehta A, Rucevic M, Sprecher E, Rosenberg LH, Lieb D, Kasumova GG, Kim MS, Bai X, Frederick DT, Flaherty K, Sullivan RJ, Hacohen N, Boland GM. The use of plasma proteomic markers to understand the biology of immunotherapy response. Journal of Clinical Oncology. 38: 10062-10062. DOI: 10.1200/Jco.2020.38.15_Suppl.10062 |
0.323 |
|
| 2020 |
Mehta A, Rucevic M, Sprecher E, Rosenberg LH, Lieb D, Kasumova G, Kim MS, Bai X, Frederick DT, Flaherty K, Sullivan RJ, Hacohen N, Boland G. Abstract LB-260: The use of blood-based protein biomarkers to uncover determinants of immunotherapy response in melanoma Cancer Research. 80. DOI: 10.1158/1538-7445.Am2020-Lb-260 |
0.363 |
|
| 2020 |
Freeman SS, Sade-Feldman M, Kim J, Stewart C, Ravi A, Arniella M, Yizhak K, Leshchiner I, Elagina L, Spiro O, Livitz D, Rosebrock D, Aguet F, Carrot-Zhang J, Gonye A, ... ... Hacohen N, et al. Abstract 6670: Combined signals from tumor and immune cells predict outcomes of checkpoint inhibition in melanoma Immunology. 80: 6670-6670. DOI: 10.1158/1538-7445.Am2020-6670 |
0.361 |
|
| 2020 |
Hong X, Roh W, Sullivan RJ, Wong KH, Wittner BS, Guo H, Dubash TD, Sade-Feldman M, Wesley BK, Boland GM, Marvin DL, Bonesteel T, Lu C, Horwitz E, Aguet F, ... ... Hacohen N, et al. Abstract 6073: The lipogenic regulatorSREBPinducesTransferrinin circulating melanoma cells, suppressing their susceptibility to ferroptosis Tumor Biology. DOI: 10.1158/1538-7445.Am2020-6073 |
0.342 |
|
| 2020 |
Arniella M, Ravi A, Stewart C, Freeman S, Awad M, Forde P, Anagnostou V, Henick B, Riess J, Gibbons D, Pennell N, Velcheti V, Leshchiner I, Kim J, Digumarthy S, ... ... Hacohen N, et al. Abstract 5902: Integrative genomic analysis of checkpoint blockade in lung cancer: A multi-institution SU2C collaborative Cancer Research. 80: 5902-5902. DOI: 10.1158/1538-7445.Am2020-5902 |
0.352 |
|
| 2020 |
Thomas M, Slowikowski K, Marc S, Nasrallah M, Manakongtreecheep K, Jessica T, Leyre Z, Misdraji J, Reynolds K, Hacohen N, Villani A. 1091 SINGLE CELL IMMUNOLOGIC DISSECTION OF HEPATITIS RELATED TO IMMUNE CHECKPOINT INHIBITOR THERAPY REVEALS INSIGHTS INTO IMMUNE TOLERANCE IN THE HUMAN LIVER Gastroenterology. 158: S-1305. DOI: 10.1016/S0016-5085(20)33924-X |
0.32 |
|
| 2020 |
Thomas M, Slowikowski K, Nasrallah M, Manakongtreecheep K, Jessica T, Leyre Z, Khalili H, Reynolds K, Dougan M, Hacohen N, Villani A. 318 SINGLE CELL DISSECTION OF THE TRANSCRIPTIONAL LANDSCAPE DEFINING CHECKPOINT INHIBITOR-ASSOCIATED COLITIS OPENS A WINDOW INTO IMMUNE DYSREGULATION IN THE HUMAN COLON Gastroenterology. 158: S-57. DOI: 10.1016/S0016-5085(20)30825-8 |
0.384 |
|
| 2019 |
Chapuy L, Bsat M, Sarkizova S, Rubio M, Therrien A, Wassef E, Bouin M, Orlicka K, Weber A, Hacohen N, Villani AC, Sarfati M. Correction: Two distinct colonic CD14 subsets characterized by single-cell RNA profiling in Crohn's disease. Mucosal Immunology. PMID 31819171 DOI: 10.1038/S41385-019-0242-5 |
0.309 |
|
| 2019 |
Zhang J, Hu X, Wang J, Sahu AD, Cohen D, Song L, Ouyang Z, Fan J, Wang B, Fu J, Gu S, Sade-Feldman M, Hacohen N, Li W, Ying X, et al. Immune receptor repertoires in pediatric and adult acute myeloid leukemia. Genome Medicine. 11: 73. PMID 31771646 DOI: 10.1186/S13073-019-0681-3 |
0.362 |
|
| 2019 |
Arazi A, Rao DA, Berthier CC, Davidson A, Liu Y, Hoover PJ, Chicoine A, Eisenhaure TM, Jonsson AH, Li S, Lieb DJ, Zhang F, Slowikowski K, Browne EP, Noma A, ... ... Hacohen N, et al. Publisher Correction: The immune cell landscape in kidneys of patients with lupus nephritis. Nature Immunology. PMID 31409923 DOI: 10.1038/S41590-019-0473-3 |
0.316 |
|
| 2019 |
Arazi A, Rao DA, Berthier CC, Davidson A, Liu Y, Hoover PJ, Chicoine A, Eisenhaure TM, Jonsson AH, Li S, Lieb DJ, Zhang F, Slowikowski K, Browne EP, Noma A, ... ... Hacohen N, et al. The immune cell landscape in kidneys of patients with lupus nephritis. Nature Immunology. PMID 31209404 DOI: 10.1038/S41590-019-0398-X |
0.429 |
|
| 2019 |
Hu X, Zhang J, Wang J, Fu J, Li T, Zheng X, Wang B, Gu S, Jiang P, Fan J, Ying X, Zhang J, Carroll MC, Wucherpfennig KW, Hacohen N, et al. Publisher Correction: Landscape of B cell immunity and related immune evasion in human cancers. Nature Genetics. PMID 31101897 DOI: 10.1038/S41588-019-0437-4 |
0.329 |
|
| 2019 |
Zhang F, Wei K, Slowikowski K, Fonseka CY, Rao DA, Kelly S, Goodman SM, Tabechian D, Hughes LB, Salomon-Escoto K, Watts GFM, Jonsson AH, Rangel-Moreno J, Meednu N, Rozo C, ... ... Hacohen N, et al. Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry. Nature Immunology. PMID 31061532 DOI: 10.1038/S41590-019-0378-1 |
0.354 |
|
| 2019 |
Ludwig LS, Lareau CA, Ulirsch JC, Christian E, Muus C, Li LH, Pelka K, Ge W, Oren Y, Brack A, Law T, Rodman C, Chen JH, Boland GM, Hacohen N, et al. Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics. Cell. PMID 30827679 DOI: 10.1016/J.Cell.2019.01.022 |
0.367 |
|
| 2019 |
Myers SA, Rhoads A, Cocco AR, Peckner R, Haber A, Schweitzer LD, Krug K, Mani DR, Clauser KR, Rozenblatt-Rosen O, Hacohen N, Regev A, Carr SA. Streamlined protocol for deep proteomic profiling of FAC-sorted cells and its application to freshly isolated murine immune cells. Molecular & Cellular Proteomics : McP. PMID 30792265 DOI: 10.1074/Mcp.Ra118.001259 |
0.413 |
|
| 2019 |
Reyes M, Vickers D, Billman K, Eisenhaure T, Hoover P, Browne EP, Rao DA, Hacohen N, Blainey PC. Multiplexed enrichment and genomic profiling of peripheral blood cells reveal subset-specific immune signatures. Science Advances. 5: eaau9223. PMID 30746468 DOI: 10.1126/Sciadv.Aau9223 |
0.43 |
|
| 2019 |
Hu X, Zhang J, Wang J, Fu J, Li T, Zheng X, Wang B, Gu S, Jiang P, Fan J, Ying X, Zhang J, Carroll MC, Wucherpfennig KW, Hacohen N, et al. Landscape of B cell immunity and related immune evasion in human cancers. Nature Genetics. PMID 30742113 DOI: 10.1038/S41588-018-0339-X |
0.384 |
|
| 2019 |
Lan YY, Heather JM, Eisenhaure T, Garris CS, Lieb D, Raychowdhury R, Hacohen N. Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation. Aging Cell. e12901. PMID 30706626 DOI: 10.1111/Acel.12901 |
0.317 |
|
| 2019 |
Chapuy L, Bsat M, Sarkizova S, Rubio M, Therrien A, Wassef E, Bouin M, Orlicka K, Weber A, Hacohen N, Villani AC, Sarfati M. Two distinct colonic CD14 subsets characterized by single-cell RNA profiling in Crohn's disease. Mucosal Immunology. PMID 30670762 DOI: 10.1038/S41385-018-0126-0 |
0.33 |
|
| 2019 |
Sade-Feldman M, Yizhak K, Bjorgaard SL, Ray JP, de Boer CG, Jenkins RW, Lieb DJ, Chen JH, Frederick DT, Barzily-Rokni M, Freeman SS, Reuben A, Hoover PJ, Villani AC, Ivanova E, ... ... Hacohen N, et al. Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma. Cell. 176: 404. PMID 30633907 DOI: 10.1016/J.Cell.2018.12.034 |
0.327 |
|
| 2019 |
Hacohen N. Abstract IA35: Determinants of effective tumor immunity Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-Ia35 |
0.382 |
|
| 2019 |
Hu Z, Leet D, Sarkizova S, Holden R, Sun J, Klaeger S, Clauser KR, Shukla SA, Zhang W, Carr SA, Fritsch EF, Pentelute BL, Hacohen N, Keskin DB, Ott PA, et al. Abstract A010: Personalized neoantigen-targeting vaccines for high-risk melanoma generate epitope spreading Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-A010 |
0.32 |
|
| 2019 |
Mehta A, Kasumova G, Shi A, Rucevic M, Sallman-Almen M, Rosenberg LH, Sprecher E, Ohmura J, Kim M, Lieb D, Bai X, Frederick DT, Kellis M, Sullivan RJ, Flaherty KT, ... Hacohen N, et al. Abstract 4533: Plasma and exosome proteomic profiling for prediction of immunotherapy response and toxicity Cancer Research. 79: 4533-4533. DOI: 10.1158/1538-7445.Sabcs18-4533 |
0.322 |
|
| 2019 |
Ouspenskaia T, Law TE, Clauser KR, Klaeger S, Keskin DB, Li B, Christian E, Chow YT, Le PM, Gould J, Ji Z, Zhang W, Bachireddy P, Sarkizova S, Hacohen N, et al. Abstract 566: Neoantigens from translated unannotated open reading frames in cancer Cancer Research. 79: 566-566. DOI: 10.1158/1538-7445.Am2019-566 |
0.356 |
|
| 2019 |
Reddy SM, Helmink B, Gao J, Zhang S, Yizhak K, Sade-Feldman M, Basar R, Blando J, Han G, Gopalakrishnan V, Zhao H, Liu W, Tawbi H, Amaria R, Davies M, ... ... Hacohen N, et al. Abstract 4488: Effector B cells and tertiary lymphoid structures predict response to immune checkpoint blockade in solid tumors Cancer Research. 79: 4488-4488. DOI: 10.1158/1538-7445.Am2019-4488 |
0.399 |
|
| 2019 |
Mehta A, Liu D, Shi A, Frederick DT, Ho L, Larque AB, Miao B, Raghavan RS, Sharova T, Shin JH, Rinaldi N, Chebib IA, Kellis M, Allen EV, Hacohen N, et al. Abstract 3013: Acquired resistance to immune checkpoint inhibition by melanoma phenotypic transformation Cancer Research. 79: 3013-3013. DOI: 10.1158/1538-7445.Am2019-3013 |
0.363 |
|
| 2019 |
Fava A, Zhang Y, Hacohen N, Arazi A, Berthier CC, Rao D, Brenner M, Wofsy D, Davidson A, Kretzler M, Hildeman D, Woodle ES, Diamond B, Petri M. 205 Single cell RNA expression in lupus nephritis comparing african-american and caucasian patients identifies differential expression of type I interferon pathway Lupus Science & Medicine. 6. DOI: 10.1136/Lupus-2019-Lsm.205 |
0.422 |
|
| 2019 |
Berthier CC, Arazi A, Rao D, Davidson A, Browne E, Eisenhaure T, Hacohen N, Lieb DJ, Diamond B, Kretzler M. 204 The immune cell landscape in kidneys of lupus nephritis patients Lupus Science & Medicine. 6. DOI: 10.1136/Lupus-2019-Lsm.204 |
0.412 |
|
| 2019 |
Fava A, Zhang Y, Hacohen N, Arazi A, Berthier C, Rao D, Brenner M, Wofsy D, Davidson A, Kretzler M, Hildeman D, Woodle ES, Diamond B, Petri MA. Ab0167 Single Cell Rna Expression In Lupus Nephritis Comparing African-American And Caucasian Patients Identifies Differential Expression Of Type I Interferon Pathway Annals of the Rheumatic Diseases. 78: 1542-1542. DOI: 10.1136/Annrheumdis-2019-Eular.5673 |
0.428 |
|
| 2019 |
Reyes M, Bhattacharyya RP, Filbin M, Billman K, Eisenhaure T, Hung DT, Levy B, Baron R, Blainey P, Goldberg MB, Hacohen N. 1830. Single-cell Transcriptional Profiling Reveals an Immune Cell State Signature of Bacterial Sepsis Open Forum Infectious Diseases. 6: S42-S42. DOI: 10.1093/Ofid/Ofz359.092 |
0.429 |
|
| 2018 |
Keskin DB, Anandappa AJ, Sun J, Tirosh I, Mathewson ND, Li S, Oliveira G, Giobbie-Hurder A, Felt K, Gjini E, Shukla SA, Hu Z, Li L, Le PM, Allesøe RL, ... ... Hacohen N, et al. Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial. Nature. PMID 30568305 DOI: 10.1038/S41586-018-0792-9 |
0.361 |
|
| 2018 |
Mahoney KM, Shukla SA, Patsoukis N, Chaudhri A, Browne EP, Arazi A, Eisenhaure TM, Pendergraft WF, Hua P, Pham HC, Bu X, Zhu B, Hacohen N, Fritsch EF, Boussiotis VA, et al. A secreted PD-L1 splice variant that covalently dimerizes and mediates immunosuppression. Cancer Immunology, Immunotherapy : Cii. PMID 30564891 DOI: 10.1007/S00262-018-2282-1 |
0.317 |
|
| 2018 |
Ye CJ, Chen J, Villani AC, Gate RE, Subramaniam M, Bhangale T, Lee MN, Raj T, Raychowdhury R, Li W, Rogel N, Simmons S, Imboywa SH, Chipendo PI, McCabe C, ... ... Hacohen N, et al. Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of transcripts under balancing selection. Genome Research. PMID 30446528 DOI: 10.1101/Gr.240390.118 |
0.422 |
|
| 2018 |
Sade-Feldman M, Yizhak K, Bjorgaard SL, Ray JP, de Boer CG, Jenkins RW, Lieb DJ, Chen JH, Frederick DT, Barzily-Rokni M, Freeman SS, Reuben A, Hoover PJ, Villani AC, Ivanova E, ... ... Hacohen N, et al. Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma. Cell. 175: 998-1013.e20. PMID 30388456 DOI: 10.1016/J.Cell.2018.10.038 |
0.405 |
|
| 2018 |
Ranu N, Villani AC, Hacohen N, Blainey PC. Targeting individual cells by barcode in pooled sequence libraries. Nucleic Acids Research. PMID 30256981 DOI: 10.1093/Nar/Gky856 |
0.393 |
|
| 2018 |
Hu Z, Anandappa AJ, Sun J, Kim J, Leet DE, Bozym DJ, Chen C, Williams L, Shukla SA, Zhang W, Tabbaa D, Steelman S, Olive O, Livak KJ, Kishi H, ... ... Hacohen N, et al. A cloning and expression system to probe T cell receptor specificity and assess functional avidity to neoantigens. Blood. PMID 30150207 DOI: 10.1182/Blood-2018-04-843763 |
0.385 |
|
| 2018 |
Gillies CE, Putler R, Menon R, Otto E, Yasutake K, Nair V, Hoover P, Lieb D, Li S, Eddy S, Fermin D, McNulty MT, Hacohen N, Kiryluk K, et al. An eQTL Landscape of Kidney Tissue in Human Nephrotic Syndrome. American Journal of Human Genetics. PMID 30057032 DOI: 10.1016/J.Ajhg.2018.07.004 |
0.392 |
|
| 2018 |
Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, ... ... Hacohen N, et al. Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue. Arthritis Research & Therapy. 20: 139. PMID 29996944 DOI: 10.1186/S13075-018-1631-Y |
0.319 |
|
| 2018 |
Grossman SR, Engreitz J, Ray JP, Nguyen TH, Hacohen N, Lander ES. Positional specificity of different transcription factor classes within enhancers. Proceedings of the National Academy of Sciences of the United States of America. PMID 29987030 DOI: 10.1073/Pnas.1804663115 |
0.319 |
|
| 2018 |
Li T, Kim A, Rosenbluh J, Horn H, Greenfeld L, An D, Zimmer A, Liberzon A, Bistline J, Natoli T, Li Y, Tsherniak A, Narayan R, Subramanian A, Liefeld T, ... ... Hacohen N, et al. GeNets: a unified web platform for network-based genomic analyses. Nature Methods. PMID 29915188 DOI: 10.1038/S41592-018-0039-6 |
0.303 |
|
| 2018 |
Pelka K, Bertheloot D, Reimer E, Phulphagar K, Schmidt SV, Christ A, Stahl R, Watson N, Miyake K, Hacohen N, Haas A, Brinkmann MM, Marshak-Rothstein A, Meissner F, Latz E. The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport. Immunity. 48: 911-922.e7. PMID 29768176 DOI: 10.1016/J.Immuni.2018.04.011 |
0.336 |
|
| 2018 |
Villani AC, Sarkizova S, Hacohen N. Systems Immunology: Learning the Rules of the Immune System. Annual Review of Immunology. 36: 813-842. PMID 29677477 DOI: 10.1146/Annurev-Immunol-042617-053035 |
0.38 |
|
| 2018 |
Shukla SA, Bachireddy P, Schilling B, Galonska C, Zhan Q, Bango C, Langer R, Lee PC, Gusenleitner D, Keskin DB, Babadi M, Mohammad A, Gnirke A, Clement K, Cartun ZJ, ... ... Hacohen N, et al. Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade. Cell. PMID 29656892 DOI: 10.1016/J.Cell.2018.03.026 |
0.339 |
|
| 2018 |
Baillie JK, Bretherick A, Haley CS, Clohisey S, Gray A, Neyton LPA, Barrett J, Stahl EA, Tenesa A, Andersson R, Brown JB, Faulkner GJ, Lizio M, Schaefer U, Daub C, ... ... Hacohen N, et al. Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease. Plos Computational Biology. 14: e1005934. PMID 29494619 DOI: 10.1371/Journal.Pcbi.1005934 |
0.375 |
|
| 2018 |
Mizoguchi F, Slowikowski K, Wei K, Marshall JL, Rao DA, Chang SK, Nguyen HN, Noss EH, Turner JD, Earp BE, Blazar PE, Wright J, Simmons BP, Donlin LT, Kalliolias GD, ... ... Hacohen N, et al. Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis. Nature Communications. 9: 789. PMID 29476097 DOI: 10.1038/S41467-018-02892-Y |
0.356 |
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| 2018 |
Pasqual G, Chudnovskiy A, Tas JMJ, Agudelo M, Schweitzer LD, Cui A, Hacohen N, Victora GD. Monitoring T cell-dendritic cell interactions in vivo by intercellular enzymatic labelling. Nature. PMID 29342141 DOI: 10.1038/Nature25442 |
0.388 |
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| 2018 |
Li S, Sun J, Anandappa A, Spiro O, Leshchiner I, Datta K, Bao Y, Hu Z, Hacohen N, Mathewson ND, Tirosh I, Wucherpfennig K, Regev A, Suva M, Keskin DB, et al. Abstract 5387: Novel targeted single-cell TCR sequencing method used for analysis of a T cell infiltrate from a glioblastoma patient Cancer Research. 78: 5387-5387. DOI: 10.1158/1538-7445.Am2018-5387 |
0.372 |
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| 2018 |
Hoover PJ, Jones TD, Costenbader KH, Hacohen N. TD-07 Dissecting the role of myeloid cells in lupus nephritis Lupus Science & Medicine. 5. DOI: 10.1136/Lupus-2018-Lsm.126 |
0.413 |
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| 2017 |
Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell PJ, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, ... ... Hacohen N, et al. Science Forum: The Human Cell Atlas. Elife. 6. PMID 29206104 DOI: 10.7554/Elife.27041 |
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| 2017 |
Sarkizova S, Hacohen N. How T cells spot tumour cells. Nature. 551: 444-446. PMID 29168843 DOI: 10.1038/D41586-017-07267-9 |
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| 2017 |
Tukiainen T, Villani AC, Yen A, Rivas MA, Marshall JL, Satija R, Aguirre M, Gauthier L, Fleharty M, Kirby A, Cummings BB, Castel SE, Karczewski KJ, Aguet F, Byrnes A, ... ... Hacohen N, et al. Landscape of X chromosome inactivation across human tissues. Nature. 550: 244-248. PMID 29022598 DOI: 10.1038/Nature24265 |
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| 2017 |
Goudot C, Coillard A, Villani AC, Gueguen P, Cros A, Sarkizova S, Tang-Huau TL, Bohec M, Baulande S, Hacohen N, Amigorena S, Segura E. Aryl Hydrocarbon Receptor Controls Monocyte Differentiation into Dendritic Cells versus Macrophages. Immunity. 47: 582-596.e6. PMID 28930664 DOI: 10.1016/J.Immuni.2017.08.016 |
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| 2017 |
Ott PA, Hu Z, Keskin DB, Shukla SA, Sun J, Bozym DJ, Zhang W, Luoma A, Giobbie-Hurder A, Peter L, Chen C, Olive O, Carter TA, Li S, Lieb DJ, ... ... Hacohen N, et al. An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. PMID 28678778 DOI: 10.1038/Nature22991 |
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| 2017 |
Mertins P, Przybylski D, Yosef N, Qiao J, Clauser K, Raychowdhury R, Eisenhaure TM, Maritzen T, Haucke V, Satoh T, Akira S, Carr SA, Regev A, Hacohen N, Chevrier N. An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling. Cell Reports. 19: 2853-2866. PMID 28658630 DOI: 10.1016/J.Celrep.2017.06.016 |
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| 2017 |
Chen JH, Pelka K, Hacohen N. Heavy Metal Enlightens Tumor Immunity. Cell. 169: 567-569. PMID 28475889 DOI: 10.1016/J.Cell.2017.04.017 |
0.301 |
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| 2017 |
Vu LP, Prieto C, Amin EM, Chhangawala S, Krivtsov A, Calvo-Vidal MN, Chou T, Chow A, Minuesa G, Park SM, Barlowe TS, Taggart J, Tivnan P, Deering RP, Chu LP, ... ... Hacohen N, et al. Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells. Nature Genetics. PMID 28436985 DOI: 10.1038/Ng.3854 |
0.769 |
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| 2017 |
Villani AC, Satija R, Reynolds G, Sarkizova S, Shekhar K, Fletcher J, Griesbeck M, Butler A, Zheng S, Lazo S, Jardine L, Dixon D, Stephenson E, Nilsson E, Grundberg I, ... ... Hacohen N, et al. Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors. Science (New York, N.Y.). 356. PMID 28428369 DOI: 10.1126/Science.Aah4573 |
0.371 |
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| 2017 |
Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell P, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, ... ... Hacohen N, et al. Author response: The Human Cell Atlas Elife. DOI: 10.7554/Elife.27041.011 |
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| 2017 |
Villani A, Chun Y, Raychowdhury R, Li W, Eisenhaure T, Regev A, Hacohen N. Abstract B13: Integrative genomic and transcriptomic analysis of 775 human cancer cell lines reveals tumor-derived immune programs and their regulators Cancer Immunology Research. 5. DOI: 10.1158/2326-6074.Tumimm16-B13 |
0.389 |
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| 2017 |
Vu L, Prieto C, Amin EM, Minuesa G, Chhangawala S, Vidal MC, Krivtsov A, Chou T, Chow A, Barlowe T, Taggart J, Tivnan P, Deering RP, Chu LP, Gonen M, ... ... Hacohen N, et al. Abstract IA13: RNA regulators and the control of self-renewal Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Hemmal17-Ia13 |
0.778 |
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| 2017 |
Rooney MS, Abelin J, Sarkizova S, Keskin D, Hartigan C, Zhang W, Sidney J, Lane W, Stevens J, Zhang GL, Clauser K, Hacohen N, Carr S, Wu C. Abstract LB-179: Next-generation epitope prediction using mass spectrometry and integrative genomics Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-179 |
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| 2017 |
Berthier C, Rao D, Arazi A, Browne E, Eisenhaure T, Hacohen N, Lieb D, Diamond B, Kretzler M. 264 Pearl: pathway exploration and analysis in renal disease in the accelerating medicine partnership (amp) lupus network Lupus Science & Medicine. 4. DOI: 10.1136/Lupus-2017-000215.264 |
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| 2016 |
Park RJ, Wang T, Koundakjian D, Hultquist JF, Lamothe-Molina P, Monel B, Schumann K, Yu H, Krupzcak KM, Garcia-Beltran W, Piechocka-Trocha A, Krogan NJ, Marson A, Sabatini DM, Lander ES, ... Hacohen N, et al. A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Nature Genetics. PMID 27992415 DOI: 10.1038/Ng.3741 |
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| 2016 |
Schumacher TN, Hacohen N. Neoantigens encoded in the cancer genome. Current Opinion in Immunology. 41: 98-103. PMID 27518850 DOI: 10.1016/J.Coi.2016.07.005 |
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| 2016 |
Li B, Li T, Pignon JC, Wang B, Wang J, Shukla SA, Dou R, Chen Q, Hodi FS, Choueiri TK, Wu C, Hacohen N, Signoretti S, Liu JS, Liu XS. Landscape of tumor-infiltrating T cell repertoire of human cancers. Nature Genetics. PMID 27240091 DOI: 10.1038/Ng.3581 |
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| 2016 |
Mostafavi S, Yoshida H, Moodley D, LeBoité H, Rothamel K, Raj T, Ye CJ, Chevrier N, Zhang SY, Feng T, Lee M, Casanova JL, Clark JD, Hegen M, Telliez JB, ... Hacohen N, et al. Parsing the Interferon Transcriptional Network and Its Disease Associations. Cell. 164: 564-578. PMID 26824662 DOI: 10.1016/J.Cell.2015.12.032 |
0.76 |
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| 2016 |
Soucie EL, Weng Z, Geirsdóttir L, Molawi K, Maurizio J, Fenouil R, Mossadegh-Keller N, Gimenez G, VanHille L, Beniazza M, Favret J, Berruyer C, Perrin P, Hacohen N, Andrau JC, et al. Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells. Science (New York, N.Y.). PMID 26797145 DOI: 10.1126/Science.Aad5510 |
0.38 |
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| 2016 |
Togami K, Madan V, Li J, Villani A, Sarkizova S, Ghandi M, Buczkowski K, Li Y, Biichle S, Angelot-Delettre F, Seiler M, Buonamici S, Taylor J, Abdel-Wahab O, Hammerman PS, ... Hacohen N, et al. Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) Harbors Frequent Splicesosome Mutations That Cause Aberrant RNA Splicing Affecting Genes Critical in pDC Differentiation and Function Blood. 128: 738-738. DOI: 10.1182/Blood.V128.22.738.738 |
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| 2016 |
Ott PA, Hu Z, Keskin DB, Shukla SA, Sun J, Fritsch E, Hacohen N, Wu CJ. Abstract PR02: A personalized neoantigen vaccine in patients with high risk melanoma Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-Pr02 |
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| 2016 |
Li B, Liu T, Wang B, Wang J, Shukla S, Dou R, Hodi S, Wu C, Hacohen N, Liu J, Liu XS. Abstract LB-264: Landscape of tumor-infiltrating T-cell repertoire of human cancers Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-264 |
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| 2015 |
Fields AP, Rodriguez EH, Jovanovic M, Stern-Ginossar N, Haas BJ, Mertins P, Raychowdhury R, Hacohen N, Carr SA, Ingolia NT, Regev A, Weissman JS. A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation. Molecular Cell. 60: 816-27. PMID 26638175 DOI: 10.1016/J.Molcel.2015.11.013 |
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| 2015 |
Parnas O, Jovanovic M, Eisenhaure TM, Herbst RH, Dixit A, Ye CJ, Przybylski D, Platt RJ, Tirosh I, Sanjana NE, Shalem O, Satija R, Raychowdhury R, Mertins P, Carr SA, ... ... Hacohen N, et al. A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks. Cell. PMID 26189680 DOI: 10.1016/J.Cell.2015.06.059 |
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| 2015 |
Ray JP, Hacohen N. Impact of autoimmune risk alleles on the immune system. Genome Medicine. 7: 57. PMID 26089985 DOI: 10.1186/S13073-015-0182-Y |
0.31 |
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| 2015 |
Ramirez-Ortiz ZG, Prasad A, Griffith JW, Pendergraft WF, Cowley GS, Root DE, Tai M, Luster AD, El Khoury J, Hacohen N, Means TK. The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity. Nature Immunology. 16: 495-504. PMID 25848864 DOI: 10.1038/Ni.3143 |
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| 2015 |
De Jager PL, Hacohen N, Mathis D, Regev A, Stranger BE, Benoist C. ImmVar project: Insights and design considerations for future studies of "healthy" immune variation. Seminars in Immunology. 27: 51-7. PMID 25819567 DOI: 10.1016/J.Smim.2015.03.003 |
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| 2015 |
Jovanovic M, Rooney MS, Mertins P, Przybylski D, Chevrier N, Satija R, Rodriguez EH, Fields AP, Schwartz S, Raychowdhury R, Mumbach MR, Eisenhaure T, Rabani M, Gennert D, Lu D, ... ... Hacohen N, et al. Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens. Science (New York, N.Y.). 347: 1259038. PMID 25745177 DOI: 10.1126/Science.1259038 |
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| 2015 |
Park SM, Gönen M, Vu L, Minuesa G, Tivnan P, Barlowe TS, Taggart J, Lu Y, Deering RP, Hacohen N, Figueroa ME, Paietta E, Fernandez HF, Tallman MS, Melnick A, et al. Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program. The Journal of Clinical Investigation. 125: 1286-98. PMID 25664853 DOI: 10.1172/Jci78440 |
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| 2015 |
Rooney MS, Shukla SA, Wu CJ, Getz G, Hacohen N. Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell. 160: 48-61. PMID 25594174 DOI: 10.1016/J.Cell.2014.12.033 |
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| 2015 |
Hacohen N. Abstract SY11-04: Genetics of immune escape Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Sy11-04 |
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| 2014 |
Rabani M, Raychowdhury R, Jovanovic M, Rooney M, Stumpo DJ, Pauli A, Hacohen N, Schier AF, Blackshear PJ, Friedman N, Amit I, Regev A. High-resolution sequencing and modeling identifies distinct dynamic RNA regulatory strategies. Cell. 159: 1698-710. PMID 25497548 DOI: 10.1016/J.Cell.2014.11.015 |
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| 2014 |
Landau DA, Clement K, Ziller MJ, Boyle P, Fan J, Gu H, Stevenson K, Sougnez C, Wang L, Li S, Kotliar D, Zhang W, Ghandi M, Garraway L, Fernandes SM, ... ... Hacohen N, et al. Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia. Cancer Cell. 26: 813-25. PMID 25490447 DOI: 10.1016/J.Ccell.2014.10.012 |
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| 2014 |
Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, ... ... Hacohen N, et al. CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Cell. 159: 440-55. PMID 25263330 DOI: 10.1016/J.Cell.2014.09.014 |
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| 2014 |
Ye CJ, Feng T, Kwon HK, Raj T, Wilson MT, Asinovski N, McCabe C, Lee MH, Frohlich I, Paik HI, Zaitlen N, Hacohen N, Stranger B, De Jager P, Mathis D, et al. Intersection of population variation and autoimmunity genetics in human T cell activation. Science (New York, N.Y.). 345: 1254665. PMID 25214635 DOI: 10.1126/Science.1254665 |
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| 2014 |
Schwartz S, Mumbach MR, Jovanovic M, Wang T, Maciag K, Bushkin GG, Mertins P, Ter-Ovanesyan D, Habib N, Cacchiarelli D, Sanjana NE, Freinkman E, Pacold ME, Satija R, Mikkelsen TS, ... Hacohen N, et al. Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Reports. 8: 284-96. PMID 24981863 DOI: 10.1016/J.Celrep.2014.05.048 |
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| 2014 |
Shalek AK, Satija R, Shuga J, Trombetta JJ, Gennert D, Lu D, Chen P, Gertner RS, Gaublomme JT, Yosef N, Schwartz S, Fowler B, Weaver S, Wang J, Wang X, ... ... Hacohen N, et al. Single-cell RNA-seq reveals dynamic paracrine control of cellular variation. Nature. 510: 363-9. PMID 24919153 DOI: 10.1038/Nature13437 |
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| 2014 |
Fritsch EF, Rajasagi M, Ott PA, Brusic V, Hacohen N, Wu CJ. HLA-binding properties of tumor neoepitopes in humans. Cancer Immunology Research. 2: 522-9. PMID 24894089 DOI: 10.1158/2326-6066.Cir-13-0227 |
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| 2014 |
Rajasagi M, Shukla SA, Fritsch EF, Keskin DB, DeLuca D, Carmona E, Zhang W, Sougnez C, Cibulskis K, Sidney J, Stevenson K, Ritz J, Neuberg D, Brusic V, Gabriel S, ... ... Hacohen N, et al. Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia. Blood. 124: 453-62. PMID 24891321 DOI: 10.1182/Blood-2014-04-567933 |
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| 2014 |
Raj T, Rothamel K, Mostafavi S, Ye C, Lee MN, Replogle JM, Feng T, Lee M, Asinovski N, Frohlich I, Imboywa S, Von Korff A, Okada Y, Patsopoulos NA, Davis S, ... ... Hacohen N, et al. Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science (New York, N.Y.). 344: 519-23. PMID 24786080 DOI: 10.1126/Science.1249547 |
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| 2014 |
Wang L, Shalek AK, Lawrence M, Ding R, Gaublomme JT, Pochet N, Stojanov P, Sougnez C, Shukla SA, Stevenson KE, Zhang W, Wong J, Sievers QL, MacDonald BT, Vartanov AR, ... ... Hacohen N, et al. Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL. Blood. 124: 1089-98. PMID 24778153 DOI: 10.1182/Blood-2014-01-552067 |
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| 2014 |
Ponichtera HE, Shainheit MG, Liu BC, Raychowdhury R, Larkin BM, Russo JM, Salantes DB, Lai CQ, Parnell LD, Yun TJ, Cheong C, Bunnell SC, Hacohen N, Stadecker MJ. CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis. Journal of Immunology (Baltimore, Md. : 1950). 192: 4655-65. PMID 24729611 DOI: 10.4049/Jimmunol.1400121 |
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| 2014 |
Lee MN, Ye C, Villani AC, Raj T, Li W, Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K, Ward LD, Raddassi K, McCabe C, Lee MH, Frohlich IY, ... ... Hacohen N, et al. Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science (New York, N.Y.). 343: 1246980. PMID 24604203 DOI: 10.1126/Science.1246980 |
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| 2014 |
Filone CM, Caballero IS, Dower K, Mendillo ML, Cowley GS, Santagata S, Rozelle DK, Yen J, Rubins KH, Hacohen N, Root DE, Hensley LE, Connor J. The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection. Plos Pathogens. 10: e1003904. PMID 24516381 DOI: 10.1371/Journal.Ppat.1003904 |
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| 2014 |
Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, ... ... Hacohen N, et al. In vivo discovery of immunotherapy targets in the tumour microenvironment. Nature. 506: 52-7. PMID 24476824 DOI: 10.1038/Nature12988 |
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| 2014 |
Giraud M, Jmari N, Du L, Carallis F, Nieland TJ, Perez-Campo FM, Bensaude O, Root DE, Hacohen N, Mathis D, Benoist C. An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription. Proceedings of the National Academy of Sciences of the United States of America. 111: 1491-6. PMID 24434558 DOI: 10.1073/Pnas.1323535111 |
0.365 |
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| 2014 |
Park SM, Deering RP, Lu Y, Tivnan P, Lianoglou S, Al-Shahrour F, Ebert BL, Hacohen N, Leslie C, Daley GQ, Lengner CJ, Kharas MG. Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs. The Journal of Experimental Medicine. 211: 71-87. PMID 24395885 DOI: 10.1084/Jem.20130736 |
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| 2014 |
Bachireddy P, Hainz U, Rooney M, Pozdnyakova O, Aldridge J, Zhang W, Liao X, Hodi FS, O'Connell K, Haining WN, Goldstein NR, Canning CM, Soiffer RJ, Ritz J, Hacohen N, et al. Reversal of in situ T-cell exhaustion during effective human antileukemia responses to donor lymphocyte infusion. Blood. 123: 1412-21. PMID 24357730 DOI: 10.1182/Blood-2013-08-523001 |
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| 2014 |
Park SM, Gönen M, Vu LP, Minuesa G, Tivnan P, Barlowe T, Taggart J, Lu Y, Deering RP, Hacohen N, Figueroa M, Paietta EM, Tallman MS, Melnick AM, Levine RL, et al. Msi2 Maintains the MLL Leukemia Stem Cell Regulatory Program Blood. 124: 836-836. DOI: 10.1182/Blood.V124.21.836.836 |
0.775 |
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| 2013 |
Ramirez-Ortiz ZG, Pendergraft WF, Prasad A, Byrne MH, Iram T, Blanchette CJ, Luster AD, Hacohen N, El Khoury J, Means TK. The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity. Nature Immunology. 14: 917-26. PMID 23892722 DOI: 10.1038/Ni.2670 |
0.402 |
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| 2013 |
Shalek AK, Satija R, Adiconis X, Gertner RS, Gaublomme JT, Raychowdhury R, Schwartz S, Yosef N, Malboeuf C, Lu D, Trombetta JJ, Gennert D, Gnirke A, Goren A, Hacohen N, et al. Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells. Nature. 498: 236-40. PMID 23685454 DOI: 10.1038/Nature12172 |
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| 2013 |
Gat-Viks I, Chevrier N, Wilentzik R, Eisenhaure T, Raychowdhury R, Steuerman Y, Shalek AK, Hacohen N, Amit I, Regev A. Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli. Nature Biotechnology. 31: 342-9. PMID 23503680 DOI: 10.1038/Nbt.2519 |
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| 2013 |
Arazi A, Pendergraft WF, Ribeiro RM, Perelson AS, Hacohen N. Human systems immunology: hypothesis-based modeling and unbiased data-driven approaches. Seminars in Immunology. 25: 193-200. PMID 23375135 DOI: 10.1016/J.Smim.2012.11.003 |
0.301 |
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| 2013 |
Lee MN, Roy M, Ong SE, Mertins P, Villani AC, Li W, Dotiwala F, Sen J, Doench JG, Orzalli MH, Kramnik I, Knipe DM, Lieberman J, Carr SA, Hacohen N. Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach. Nature Immunology. 14: 179-85. PMID 23263557 DOI: 10.1038/Ni.2509 |
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| 2013 |
Landau D, Clement K, Boyle P, Ziller M, Stevenson KE, Kotliar D, Saksena G, Eng M, Sougnez C, Zhang W, Ghandi M, Garraway L, Gabriel S, Lander ES, Brown JR, ... ... Hacohen N, et al. Increased Local Disorder of DNA Methylation Forms the Basis of High Intra-Leukemic Epigenetic Heterogeneity and Enhances CLL Evolution Blood. 122: 596-596. DOI: 10.1182/Blood.V122.21.596.596 |
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| 2013 |
Rajasagi M, Shukla SA, Fritsch EF, DeLuca D, Getz G, Hacohen N, Wu CJ. Tumor Neoantigens Are Abundant Across Cancers Blood. 122: 3265-3265. DOI: 10.1182/Blood.V122.21.3265.3265 |
0.304 |
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| 2013 |
Kotliar D, Landau D, Litvin O, Stojanov P, Sougnez C, Saksena G, Eng M, Neuberg DS, Getz G, Brown JR, Pe'er D, Hacohen N, Wu CJ. Reconstructing a Genotype-Phenotype Map In Chronic Lymphocytic Leukemia Blood. 122: 2857-2857. DOI: 10.1182/Blood.V122.21.2857.2857 |
0.371 |
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| 2012 |
Shalek AK, Gaublomme JT, Wang L, Yosef N, Chevrier N, Andersen MS, Robinson JT, Pochet N, Neuberg D, Gertner RS, Amit I, Brown JR, Hacohen N, Regev A, Wu CJ, et al. Nanowire-mediated delivery enables functional interrogation of primary immune cells: application to the analysis of chronic lymphocytic leukemia. Nano Letters. 12: 6498-504. PMID 23190424 DOI: 10.1021/Nl3042917 |
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| 2012 |
Garber M, Yosef N, Goren A, Raychowdhury R, Thielke A, Guttman M, Robinson J, Minie B, Chevrier N, Itzhaki Z, Blecher-Gonen R, Bornstein C, Amann-Zalcenstein D, Weiner A, Friedrich D, ... ... Hacohen N, et al. A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals. Molecular Cell. 47: 810-22. PMID 22940246 DOI: 10.1016/J.Molcel.2012.07.030 |
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| 2012 |
Moita CF, Chora Â, Hacohen N, Moita LF. RNAi screen for kinases and phosphatases that play a role in antigen presentation by dendritic cells. European Journal of Immunology. 42: 1843-9. PMID 22585713 DOI: 10.1002/Eji.201142167 |
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| 2012 |
Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Molecular & Cellular Proteomics : McP. 11: 148-59. PMID 22505724 DOI: 10.1074/Mcp.M111.016857 |
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| 2012 |
Moseman EA, Iannacone M, Bosurgi L, Tonti E, Chevrier N, Tumanov A, Fu YX, Hacohen N, von Andrian UH. B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. Immunity. 36: 415-26. PMID 22386268 DOI: 10.1016/J.Immuni.2012.01.013 |
0.746 |
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| 2012 |
Rajasagi M, Keskin D, Kim J, Zhang W, Shukla S, DeLuca D, Sidney J, Brusic V, Neuberg DS, Getz G, Lander ES, Hacohen N, Wu CJ. Systematic Identification of Personal Mutated Tumor-Specific Neoantigens in CLL Blood. 120: 954-954. DOI: 10.1182/Blood.V120.21.954.954 |
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| 2012 |
Bachireddy P, Hainz U, Rooney M, Pozdnyakova O, Aldridge J, Haining WN, Goldstein NR, Canning CM, Soiffer RJ, Ritz J, Hacohen N, Kim HT, Alyea EP, Wu CJ. Reversal of T Cell Exhaustion in Pre-Treatment Marrow T Cells Is Associated with Effective Graft-Versus-Leukemia Responses to Donor Lymphocyte Infusion Blood. 120: 1903-1903. DOI: 10.1182/Blood.V120.21.1903.1903 |
0.4 |
|
| 2011 |
Wang L, Lawrence MS, Wan Y, Stojanov P, Sougnez C, Stevenson K, Werner L, Sivachenko A, DeLuca DS, Zhang L, Zhang W, Vartanov AR, Fernandes SM, Goldstein NR, Folco EG, ... ... Hacohen N, et al. SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. The New England Journal of Medicine. 365: 2497-506. PMID 22150006 DOI: 10.1056/Nejmoa1109016 |
0.324 |
|
| 2011 |
Amit I, Regev A, Hacohen N. Strategies to discover regulatory circuits of the mammalian immune system. Nature Reviews. Immunology. 11: 873-80. PMID 22094988 DOI: 10.1038/Nri3109 |
0.362 |
|
| 2011 |
Chevrier N, Mertins P, Artyomov MN, Shalek AK, Iannacone M, Ciaccio MF, Gat-Viks I, Tonti E, DeGrace MM, Clauser KR, Garber M, Eisenhaure TM, Yosef N, Robinson J, Sutton A, ... ... Hacohen N, et al. Systematic discovery of TLR signaling components delineates viral-sensing circuits. Cell. 147: 853-67. PMID 22078882 DOI: 10.1016/J.Cell.2011.10.022 |
0.749 |
|
| 2011 |
Garg S, Sharma M, Ung C, Tuli A, Barral DC, Hava DL, Veerapen N, Besra GS, Hacohen N, Brenner MB. Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b. Immunity. 35: 182-93. PMID 21802320 DOI: 10.1016/J.Immuni.2011.06.009 |
0.378 |
|
| 2011 |
Wang S, Villablanca EJ, De Calisto J, Gomes DC, Nguyen DD, Mizoguchi E, Kagan JC, Reinecker HC, Hacohen N, Nagler C, Xavier RJ, Rossi-Bergmann B, Chen YB, Blomhoff R, Snapper SB, et al. MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties. Journal of Immunology (Baltimore, Md. : 1950). 187: 141-50. PMID 21646294 DOI: 10.4049/Jimmunol.1003740 |
0.351 |
|
| 2011 |
Vander Lugt B, Beck ZT, Fuhlbrigge RC, Hacohen N, Campbell JJ, Boes M. TGF-β suppresses β-catenin-dependent tolerogenic activation program in dendritic cells. Plos One. 6: e20099. PMID 21625453 DOI: 10.1371/Journal.Pone.0020099 |
0.319 |
|
| 2011 |
Moura-Alves P, Neves-Costa A, Raquel H, Pacheco TR, D'Almeida B, Rodrigues R, Cadima-Couto I, Chora Â, Oliveira M, Gama-Carvalho M, Hacohen N, Moita LF. An shRNA-based screen of splicing regulators identifies SFRS3 as a negative regulator of IL-1β secretion. Plos One. 6: e19829. PMID 21611201 DOI: 10.1371/Journal.Pone.0019829 |
0.336 |
|
| 2011 |
Grabherr MG, Haas BJ, Yassour M, Levin JZ, Thompson DA, Amit I, Adiconis X, Fan L, Raychowdhury R, Zeng Q, Chen Z, Mauceli E, Hacohen N, Gnirke A, Rhind N, et al. Full-length transcriptome assembly from RNA-Seq data without a reference genome. Nature Biotechnology. 29: 644-52. PMID 21572440 DOI: 10.1038/Nbt.1883 |
0.307 |
|
| 2011 |
Benoist C, Hacohen N. Flow cytometry, amped up Science. 332: 677-678. PMID 21551055 DOI: 10.1126/Science.1206351 |
0.401 |
|
| 2011 |
Rabani M, Levin JZ, Fan L, Adiconis X, Raychowdhury R, Garber M, Gnirke A, Nusbaum C, Hacohen N, Friedman N, Amit I, Regev A. Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells. Nature Biotechnology. 29: 436-42. PMID 21516085 DOI: 10.1038/Nbt.1861 |
0.326 |
|
| 2011 |
Pe'er D, Hacohen N. Principles and strategies for developing network models in cancer. Cell. 144: 864-73. PMID 21414479 DOI: 10.1016/J.Cell.2011.03.001 |
0.331 |
|
| 2011 |
Lin Y, Zhang L, Cai AX, Lee M, Zhang W, Neuberg D, Canning CM, Soiffer RJ, Alyea EP, Ritz J, Hacohen N, Means TK, Wu CJ. Effective posttransplant antitumor immunity is associated with TLR-stimulating nucleic acid-immunoglobulin complexes in humans. The Journal of Clinical Investigation. 121: 1574-84. PMID 21403403 DOI: 10.1172/Jci44581 |
0.37 |
|
| 2011 |
Shapira SD, Hacohen N. Systems biology approaches to dissect mammalian innate immunity. Current Opinion in Immunology. 23: 71-7. PMID 21111589 DOI: 10.1016/J.Coi.2010.10.022 |
0.35 |
|
| 2011 |
Wang L, Shalek AK, Gaublomme J, Yosef N, Brown JR, Neuberg D, Hacohen N, Park H, Wu CJ. Sensitivity to Wnt Pathway Inhibition in CLL Is Associated with Specific Gene Expression Signatures Blood. 118: 801-801. DOI: 10.1182/Blood.V118.21.801.801 |
0.425 |
|
| 2011 |
Wan Y, Lawrence MS, Wang L, Stojanov P, Sougnez C, Stevenson K, Werner L, Zhang W, Folco EG, Tesar B, Sievers QL, Gabriel S, Hacohen N, Reed R, Meyerson M, et al. Large-Scale CLL Genome Analysis Reveals Novel Cancer Genes, Including SF3B1 Blood. 118: 463-463. DOI: 10.1182/Blood.V118.21.463.463 |
0.301 |
|
| 2010 |
Dougan M, Dougan S, Slisz J, Firestone B, Vanneman M, Draganov D, Goyal G, Li W, Neuberg D, Blumberg R, Hacohen N, Porter D, Zawel L, Dranoff G. IAP inhibitors enhance co-stimulation to promote tumor immunity. The Journal of Experimental Medicine. 207: 2195-206. PMID 20837698 DOI: 10.1084/Jem.20101123 |
0.41 |
|
| 2010 |
Colvin RA, Means TK, Diefenbach TJ, Moita LF, Friday RP, Sever S, Campanella GS, Abrazinski T, Manice LA, Moita C, Andrews NW, Wu D, Hacohen N, Luster AD. Synaptotagmin-mediated vesicle fusion regulates cell migration. Nature Immunology. 11: 495-502. PMID 20473299 DOI: 10.1038/Ni.1878 |
0.354 |
|
| 2010 |
Dixit E, Boulant S, Zhang Y, Lee AS, Odendall C, Shum B, Hacohen N, Chen ZJ, Whelan SP, Fransen M, Nibert ML, Superti-Furga G, Kagan JC. Peroxisomes are signaling platforms for antiviral innate immunity. Cell. 141: 668-81. PMID 20451243 DOI: 10.1016/J.Cell.2010.04.018 |
0.368 |
|
| 2010 |
Rato S, Maia S, Brito PM, Resende L, Pereira CF, Moita C, Freitas RP, Moniz-Pereira J, Hacohen N, Moita LF, Goncalves J. Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells. Plos One. 5: e9276. PMID 20174665 DOI: 10.1371/Journal.Pone.0009276 |
0.33 |
|
| 2010 |
Astier AL, Beriou G, Eisenhaure TM, Anderton SM, Hafler DA, Hacohen N. RNA interference screen in primary human T cells reveals FLT3 as a modulator of IL-10 levels. Journal of Immunology (Baltimore, Md. : 1950). 184: 685-93. PMID 20018615 DOI: 10.4049/Jimmunol.0902443 |
0.358 |
|
| 2010 |
Ostrowski M, Carmo NB, Krumeich S, Fanget I, Raposo G, Savina A, Moita CF, Schauer K, Hume AN, Freitas RP, Goud B, Benaroch P, Hacohen N, Fukuda M, Desnos C, et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nature Cell Biology. 12: 19-30; sup pp 1-13. PMID 19966785 DOI: 10.1038/Ncb2000 |
0.337 |
|
| 2010 |
Wang L, Pochet N, Cibulskis K, Zhang W, Lawrence M, Sievers QL, Shefler E, Neuberg D, Gabriel S, Sougnez C, Regev A, Getz G, Hacohen N, Brown JR, Wu CJ. Whole Genome Sequencing Identifies Functional Mutations In the Wnt Pathway In CLL Blood. 116: 693-693. DOI: 10.1182/Blood.V116.21.693.693 |
0.407 |
|
| 2009 |
Shapira SD, Gat-Viks I, Shum BO, Dricot A, de Grace MM, Wu L, Gupta PB, Hao T, Silver SJ, Root DE, Hill DE, Regev A, Hacohen N. A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection. Cell. 139: 1255-67. PMID 20064372 DOI: 10.1016/J.Cell.2009.12.018 |
0.334 |
|
| 2009 |
Amit I, Garber M, Chevrier N, Leite AP, Donner Y, Eisenhaure T, Guttman M, Grenier JK, Li W, Zuk O, Schubert LA, Birditt B, Shay T, Goren A, Zhang X, ... ... Hacohen N, et al. Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science (New York, N.Y.). 326: 257-63. PMID 19729616 DOI: 10.1126/Science.1179050 |
0.761 |
|
| 2009 |
Ali N, Karlsson C, Aspling M, Hu G, Hacohen N, Scadden DT, Larsson J. Forward RNAi screens in primary human hematopoietic stem/progenitor cells. Blood. 113: 3690-5. PMID 19188664 DOI: 10.1182/Blood-2008-10-176396 |
0.353 |
|
| 2009 |
Guttman M, Amit I, Garber M, French C, Lin MF, Feldser D, Huarte M, Zuk O, Carey BW, Cassady JP, Cabili MN, Jaenisch R, Mikkelsen TS, Jacks T, Hacohen N, et al. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature. 458: 223-7. PMID 19182780 DOI: 10.1038/Nature07672 |
0.4 |
|
| 2009 |
Raquel H, Moita C, Hacohen N, Moita L. Identification of genes involved in unconventional protein secretion pathways Cytokine. 48: 118. DOI: 10.1016/J.Cyto.2009.07.499 |
0.32 |
|
| 2008 |
Luo B, Cheung HW, Subramanian A, Sharifnia T, Okamoto M, Yang X, Hinkle G, Boehm JS, Beroukhim R, Weir BA, Mermel C, Barbie DA, Awad T, Zhou X, Nguyen T, ... ... Hacohen N, et al. Highly parallel identification of essential genes in cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 20380-5. PMID 19091943 DOI: 10.1073/Pnas.0810485105 |
0.383 |
|
| 2008 |
Oberdoerffer S, Moita LF, Neems D, Freitas RP, Hacohen N, Rao A. Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL. Science (New York, N.Y.). 321: 686-91. PMID 18669861 DOI: 10.1126/Science.1157610 |
0.378 |
|
| 2008 |
Adams EW, Ratner DM, Seeberger PH, Hacohen N. Carbohydrate-mediated targeting of antigen to dendritic cells leads to enhanced presentation of antigen to T cells. Chembiochem : a European Journal of Chemical Biology. 9: 294-303. PMID 18186095 DOI: 10.1002/Cbic.200700310 |
0.333 |
|
| 2008 |
Acharya S, Hacohen N, Soares L, Fathman C. OR.37. shRNA Mediated Downregulation of Genes Identified as ‘Core Transcriptome’ in Murine T Regulatory Cells Clinical Immunology. 127. DOI: 10.1016/J.Clim.2008.03.503 |
0.375 |
|
| 2008 |
Astier A, Beriou G, Eisenhaure T, Hafler D, Hacohen N. Flt3, a New Regulator of IL-10 Production by Human T Cells, Identified Using an RNAi Library Clinical Immunology. 127. DOI: 10.1016/J.Clim.2008.03.074 |
0.301 |
|
| 2006 |
Pacheco TR, Moita LF, Gomes AQ, Hacohen N, Carmo-Fonseca M. RNA interference knockdown of hU2AF35 impairs cell cycle progression and modulates alternative splicing of Cdc25 transcripts. Molecular Biology of the Cell. 17: 4187-99. PMID 16855028 DOI: 10.1091/Mbc.E06-01-0036 |
0.426 |
|
| 2006 |
Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N, et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell. 124: 1283-98. PMID 16564017 DOI: 10.1016/J.Cell.2006.01.040 |
0.358 |
|
| 2006 |
Astier A, Beriou G, Eisenhaure T, Hafler D, Hacohen N. OR.80. Identifying Regulators of Cytokine Production in Primary Human T-Cells Using a Lentiviral RNAi Library Clinical Immunology. 119. DOI: 10.1016/J.Clim.2006.04.385 |
0.346 |
|
| 2004 |
Palliser D, Huang Q, Hacohen N, Lamontagne SP, Guillen E, Young RA, Eisen HN. A role for Toll-like receptor 4 in dendritic cell activation and cytolytic CD8+ T cell differentiation in response to a recombinant heat shock fusion protein. Journal of Immunology (Baltimore, Md. : 1950). 172: 2885-93. PMID 14978090 DOI: 10.4049/Jimmunol.172.5.2885 |
0.346 |
|
| 2002 |
Alcamo E, Hacohen N, Schulte LC, Rennert PD, Hynes RO, Baltimore D. Requirement for the NF-kappaB family member RelA in the development of secondary lymphoid organs. The Journal of Experimental Medicine. 195: 233-44. PMID 11805150 DOI: 10.1084/Jem.20011885 |
0.319 |
|
| 2001 |
Huang Q, Liu D, Majewski P, Schulte LC, Korn JM, Young RA, Lander ES, Hacohen N. The plasticity of dendritic cell responses to pathogens and their components. Science (New York, N.Y.). 294: 870-5. PMID 11679675 DOI: 10.1126/Science.294.5543.870 |
0.413 |
|
| 1998 |
Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow MA. sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Cell. 92: 253-63. PMID 9458049 DOI: 10.1016/S0092-8674(00)80919-8 |
0.329 |
|
| 1996 |
Lee T, Hacohen N, Krasnow M, Montell DJ. Regulated Breathless receptor tyrosine kinase activity required to pattern cell migration and branching in the Drosophila tracheal system. Genes & Development. 10: 2912-21. PMID 8918892 DOI: 10.1101/Gad.10.22.2912 |
0.378 |
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