| Year |
Citation |
Score |
| 2023 |
Cantley J, Poitout V, Hull-Meichle RL. 100 years of glucagon anniversary, special collection - editorial. The Journal of Endocrinology. PMID 37194667 DOI: 10.1530/JOE-23-0138 |
0.349 |
|
| 2023 |
Lacombe J, Guo K, Bonneau J, Faubert D, Gioanni F, Vivoli A, Muir SM, Hezzaz S, Poitout V, Ferron M. Vitamin K-dependent carboxylation regulates Ca flux and adaptation to metabolic stress in β cells. Cell Reports. 42: 112500. PMID 37171959 DOI: 10.1016/j.celrep.2023.112500 |
0.337 |
|
| 2022 |
Vivoli A, Ghislain J, Filali-Mouhim A, Angeles ZE, Castell AL, Sladek R, Poitout V. Single-cell RNA Sequencing Reveals a Role for Reactive Oxygen Species and Peroxiredoxins in Fatty-Acid-Induced Rat Beta-Cell Proliferation. Diabetes. PMID 36191509 DOI: 10.2337/db22-0121 |
0.353 |
|
| 2022 |
Castell AL, Goubault C, Ethier M, Fergusson G, Tremblay C, Baltz M, Dal Soglio D, Ghislain J, Poitout V. Beta-cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood. Jci Insight. PMID 36107617 DOI: 10.1172/jci.insight.160854 |
0.415 |
|
| 2022 |
Castell AL, Vivoli A, Tippetts TS, Frayne IR, Angeles ZE, Moullé VS, Campbell SA, Ruiz M, Ghislain J, Rosiers CD, Holland WL, Summers SA, Poitout V. Very Long-Chain Unsaturated Sphingolipids Mediate Oleate-Induced Rat β-Cell Proliferation. Diabetes. PMID 35287172 DOI: 10.2337/db21-0640 |
0.343 |
|
| 2021 |
Jouvet N, Bouyakdan K, Campbell SA, Baldwin C, Townsend SE, Gannon MA, Poitout V, Alquier T, Estall JL. The Tetracycline-Controlled Transactivator (Tet-On/Off) System in Beta Cells Reduces Insulin Expression and Secretion in Mice. Diabetes. PMID 34610983 DOI: 10.2337/db21-0147 |
0.484 |
|
| 2021 |
Maachi H, Ghislain J, Tremblay C, Poitout V. Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans. Scientific Reports. 11: 11283. PMID 34050242 DOI: 10.1038/s41598-021-90643-3 |
0.303 |
|
| 2021 |
Croze ML, Guillaume A, Ethier M, Fergusson G, Tremblay C, Campbell SA, Maachi H, Ghislain J, Poitout V. Combined Deletion of Free Fatty-Acid Receptors 1 and 4 Minimally Impacts Glucose Homeostasis in Mice. Endocrinology. 162. PMID 33543237 DOI: 10.1210/endocr/bqab002 |
0.471 |
|
| 2021 |
Ghislain J, Poitout V. Targeting lipid GPCRs to treat type 2 diabetes mellitus - progress and challenges. Nature Reviews. Endocrinology. PMID 33495605 DOI: 10.1038/s41574-020-00459-w |
0.411 |
|
| 2021 |
Croze ML, Flisher MF, Guillaume A, Tremblay C, Noguchi GM, Granziera S, Vivot K, Castillo VC, Campbell SA, Ghislain J, Huising MO, Poitout V. Free fatty-acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice. Molecular Metabolism. 101166. PMID 33484949 DOI: 10.1016/j.molmet.2021.101166 |
0.488 |
|
| 2021 |
Croze ML, Guillaume A, Ethier M, Fergusson G, Tremblay C, Campbell SA, Maachi H, Ghislain J, Poitout V. Combined deletion of free fatty-acid receptors 1 and 4 minimally impacts glucose homeostasis in mice. Endocrinology. PMID 33406231 DOI: 10.1210/endocr/bqab002 |
0.47 |
|
| 2020 |
VIVOLI A, CASTELL A, PACIS A, SLADEK RM, GHISLAIN J, POITOUT V. 2098-P: Transcriptomic Changes Associated with Oleate-Induced ß-Cell Proliferation in Rat Islets Diabetes. 69: 2098-P. DOI: 10.2337/Db20-2098-P |
0.325 |
|
| 2020 |
CASTELL A, FERGUSSON G, ETHIER M, TREMBLAY C, GHISLAIN J, POITOUT V. 2068-P: Beta-Cell Compensation to Pubertal Insulin Resistance Is Compromised in High-Fat Fed Rats and Impairs Glucose Homeostasis Later in Life Diabetes. 69: 2068-P. DOI: 10.2337/Db20-2068-P |
0.58 |
|
| 2019 |
Maachi H, Fergusson G, Ethier M, Brill GN, Katz LS, Honig LB, Metukuri MR, Scott DK, Ghislain J, Poitout V. HB-EGF Signaling is Required for Glucose-Induced Pancreatic β-cell Proliferation in Rats. Diabetes. PMID 31882563 DOI: 10.2337/Db19-0643 |
0.489 |
|
| 2019 |
Lytrivi M, Anne-Laure C, Poitout V, Cnop M. Recent insights into mechanisms of β-cell lipo- and glucolipotoxicity in type 2 diabetes. Journal of Molecular Biology. PMID 31628942 DOI: 10.1016/J.Jmb.2019.09.016 |
0.485 |
|
| 2019 |
Khan S, Ferdaoussi M, Bautista A, Bergeron V, Smith N, Poitout V, MacDonald PE. A role for PKD1 in insulin secretion downstream of P2Y receptor activation in mouse and human islets. Physiological Reports. 7: e14250. PMID 31591827 DOI: 10.14814/Phy2.14250 |
0.592 |
|
| 2019 |
Moullé VS, Tremblay C, Castell AL, Vivot K, Ethier M, Fergusson G, Alquier T, Ghislain J, Poitout V. The autonomic nervous system regulates pancreatic beta-cell proliferation in adult male rats. American Journal of Physiology. Endocrinology and Metabolism. PMID 31013146 DOI: 10.1152/Ajpendo.00385.2018 |
0.465 |
|
| 2019 |
MAACHI H, SCOTT D, GHISLAIN J, POITOUT V. 2196-P: HB-EGF Signaling Is Required for Glucose-Induced Pancreatic ß-Cell Proliferation in Rats Diabetes. 68: 2196-P. DOI: 10.2337/db19-2196-P |
0.353 |
|
| 2019 |
CASTELL A, VIVOLI A, MOULLÉ VS, GHISLAIN J, POITOUT V. 2177-P: Role of De Novo Sphingolipid Metabolites in Oleate-Induced Pancreatic ß-Cell Proliferation in Rats Diabetes. 68: 2177-P. DOI: 10.2337/Db19-2177-P |
0.324 |
|
| 2019 |
CASTELL A, ETHIER M, FERGUSSON G, GHISLAIN J, POITOUT V. 2159-P: Beta-Cell Compensation to Pubertal Insulin Resistance Is Compromised in High-Fat Fed Rats and Impairs Glucose Homeostasis Later in Life Diabetes. 68: 2159-P. DOI: 10.2337/DB19-2159-P |
0.451 |
|
| 2019 |
CROZE ML, GRANZIERA S, VIVOT K, SZPIGEL A, GHISLAIN J, POITOUT V. 200-OR: Role of Delta Cell Gpr120 in the Regulation of Islet Function and Glucose Control Diabetes. 68: 200-OR. DOI: 10.2337/Db19-200-Or |
0.617 |
|
| 2018 |
Poitout V, Satin LS, Kahn SE, Stoffers DA, Marchetti P, Gannon M, Verchere CB, Herold KC, Myers MG, Marshall SM. A Call for Improved Reporting of Human Islet Characteristics in Research Articles. Diabetes. PMID 30552106 DOI: 10.2337/Dbi18-0055 |
0.329 |
|
| 2018 |
Poitout V. Fatty Acids and Insulin Secretion: From FFAR and Near? Diabetes. 67: 1932-1934. PMID 30237161 DOI: 10.2337/Dbi18-0027 |
0.61 |
|
| 2018 |
Seferovic MD, Beamish CA, Mosser RE, Townsend SE, Pappan K, Poitout V, Aagaard K, Gannon M. Increases in bioactive lipids accompany early metabolic changes associated with β-cell expansion in response to short-term high fat diet. American Journal of Physiology. Endocrinology and Metabolism. PMID 30106624 DOI: 10.1152/Ajpendo.00001.2018 |
0.387 |
|
| 2017 |
Alquier T, Poitout V. Considerations and guidelines for mouse metabolic phenotyping in diabetes research. Diabetologia. PMID 29143855 DOI: 10.1007/S00125-017-4495-9 |
0.373 |
|
| 2017 |
Bergeron V, Ghislain J, Vivot K, Tamarina N, Philipson LH, Fielitz J, Poitout V. Deletion of Protein Kinase D1 in Pancreatic Beta Cells Impairs Insulin Secretion in High-Fat Fed Mice. Diabetes. PMID 29038309 DOI: 10.2337/Db17-0982 |
0.546 |
|
| 2017 |
Moullé VS, Ghislain J, Poitout V. Nutrient regulation of pancreatic β-cell proliferation. Biochimie. PMID 28987628 DOI: 10.1016/J.Biochi.2017.09.017 |
0.512 |
|
| 2017 |
Moullé VS, Vivot K, Tremblay C, Zarrouki B, Ghislain J, Poitout V. Glucose and fatty acids synergistically and reversibly promote beta cell proliferation in rats. Diabetologia. PMID 28078385 DOI: 10.1007/S00125-016-4197-8 |
0.596 |
|
| 2016 |
Ghislain J, Poitout V. The Role and Future of FFA1 as a Therapeutic Target. Handbook of Experimental Pharmacology. PMID 27807697 DOI: 10.1007/164_2016_51 |
0.571 |
|
| 2016 |
Bergeron V, Ghislain J, Poitout V. The P21-activated kinase PAK4 is implicated in fatty-acid potentiation of insulin secretion downstream of free fatty acid receptor 1. Islets. 0. PMID 27700527 DOI: 10.1080/19382014.2016.1243191 |
0.607 |
|
| 2016 |
Vivot K, Moullé VS, Zarrouki B, Tremblay C, Mancini AD, Maachi H, Ghislain J, Poitout V. The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets. Molecular Metabolism. 5: 988-96. PMID 27689011 DOI: 10.1016/J.Molmet.2016.08.010 |
0.462 |
|
| 2016 |
Koppe L, Nyam E, Vivot K, Manning Fox JE, Dai XQ, Nguyen BN, Trudel D, Attané C, Moullé VS, MacDonald PE, Ghislain J, Poitout V. Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease. The Journal of Clinical Investigation. PMID 27525435 DOI: 10.1172/Jci86181 |
0.563 |
|
| 2016 |
Koppe L, Poitout V. CMPF: A Biomarker for Type 2 Diabetes Mellitus Progression? Trends in Endocrinology and Metabolism: Tem. 27: 439-40. PMID 27132217 DOI: 10.1016/J.Tem.2016.04.010 |
0.487 |
|
| 2016 |
Auguste S, Fisette A, Fernandes MF, Hryhorczuk C, Poitout V, Alquier T, Fulton S. Central Agonism of GPR120 Acutely Inhibits Food Intake and Food Reward and Chronically Suppresses Anxiety-Like Behavior in Mice. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). PMID 26888796 DOI: 10.1093/Ijnp/Pyw014 |
0.348 |
|
| 2016 |
Ghislain J, Fontés G, Tremblay C, Kebede MA, Poitout V. Dual-Reporter β-Cell-Specific Male Transgenic Rats for the Analysis of β-Cell Functional Mass and Enrichment by Flow Cytometry. Endocrinology. 157: 1299-306. PMID 26671180 DOI: 10.1210/En.2015-1550 |
0.533 |
|
| 2015 |
Oropeza D, Jouvet N, Bouyakdan K, Perron G, Ringuette LJ, Philipson LH, Kiss RS, Poitout V, Alquier T, Estall JL. PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids. Molecular Metabolism. 4: 811-22. PMID 26629405 DOI: 10.1016/J.Molmet.2015.08.001 |
0.539 |
|
| 2015 |
Fontés G, Ghislain J, Benterki I, Zarrouki B, Trudel D, Berthiaume Y, Poitout V. The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice. Diabetes. 64: 4112-22. PMID 26283735 DOI: 10.2337/Db14-0810 |
0.525 |
|
| 2015 |
Mancini AD, Bertrand G, Vivot K, Carpentier É, Tremblay C, Ghislain J, Bouvier M, Poitout V. β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1. The Journal of Biological Chemistry. 290: 21131-40. PMID 26157145 DOI: 10.1074/Jbc.M115.644450 |
0.444 |
|
| 2015 |
Oropeza D, Jouvet N, Budry L, Campbell JE, Bouyakdan K, Lacombe J, Perron G, Bergeron V, Neuman JC, Brar HK, Fenske RJ, Meunier C, Sczelecki S, Kimple ME, Drucker DJ, ... ... Poitout V, et al. Phenotypic characterization of MIP-CreERT1Lphi mice with transgene-driven islet expression of human growth hormone. Diabetes. PMID 26153246 DOI: 10.2337/Db15-0272 |
0.573 |
|
| 2015 |
Priyadarshini M, Villa SR, Fuller M, Wicksteed B, Mackay CR, Alquier T, Poitout V, Mancebo H, Mirmira RG, Gilchrist A, Layden BT. An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion. Molecular Endocrinology (Baltimore, Md.). 29: 1055-66. PMID 26075576 DOI: 10.1210/Me.2015-1007 |
0.612 |
|
| 2015 |
Mosser RE, Maulis MF, Moullé VS, Dunn JC, Carboneau BA, Arasi K, Pappan K, Poitout V, Gannon M. High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice. American Journal of Physiology. Endocrinology and Metabolism. 308: E573-82. PMID 25628421 DOI: 10.1152/Ajpendo.00460.2014 |
0.518 |
|
| 2015 |
Mancini AD, Poitout V. GPR40 agonists for the treatment of type 2 diabetes: life after 'TAKing' a hit. Diabetes, Obesity & Metabolism. 17: 622-9. PMID 25604916 DOI: 10.1111/Dom.12442 |
0.43 |
|
| 2014 |
Fergusson G, Ethier M, Guévremont M, Chrétien C, Attané C, Joly E, Fioramonti X, Prentki M, Poitout V, Alquier T. Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice. Molecular Metabolism. 3: 848-54. PMID 25506550 DOI: 10.1016/J.Molmet.2014.09.006 |
0.56 |
|
| 2014 |
Semache M, Ghislain J, Zarrouki B, Tremblay C, Poitout V. Pancreatic and duodenal homeobox-1 nuclear localization is regulated by glucose in dispersed rat islets but not in insulin-secreting cell lines. Islets. 6: e982376. PMID 25437380 DOI: 10.4161/19382014.2014.982376 |
0.623 |
|
| 2014 |
Kilic G, Alvarez-Mercado AI, Zarrouki B, Opland D, Liew CW, Alonso LC, Myers MG, Jonas JC, Poitout V, Kulkarni RN, Mauvais-Jarvis F. The islet estrogen receptor-α is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes. Plos One. 9: e87941. PMID 24498408 DOI: 10.1371/Journal.Pone.0087941 |
0.481 |
|
| 2014 |
Zarrouki B, Benterki I, Fontés G, Peyot ML, Seda O, Prentki M, Poitout V. Epidermal growth factor receptor signaling promotes pancreatic β-cell proliferation in response to nutrient excess in rats through mTOR and FOXM1. Diabetes. 63: 982-93. PMID 24194502 DOI: 10.2337/Db13-0425 |
0.446 |
|
| 2014 |
Mancini A, Bertrand G, Vivot K, Carpentier E, Ghislain J, Bouvier M, Poitout V. Beta-Arrestin 2 Recruitment and Biased Agonism at the Free Fatty Acid Receptor GPR40 Canadian Journal of Diabetes. 38: S66. DOI: 10.1016/J.Jcjd.2014.07.187 |
0.402 |
|
| 2014 |
Nyam E, Semache M, Poitout V. Glucose Regulation of Pdx-1 Does Not Involve Changes in Pcif1 Protein Expression Canadian Journal of Diabetes. 38: 151. DOI: 10.1016/J.Jcjd.2014.02.011 |
0.431 |
|
| 2013 |
Poitout V, Lin DC. Modulating GPR40: therapeutic promise and potential in diabetes. Drug Discovery Today. 18: 1301-8. PMID 24051395 DOI: 10.1016/J.Drudis.2013.09.003 |
0.553 |
|
| 2013 |
d'Assignies G, Fontés G, Kauffmann C, Latour M, Gaboury L, Boulanger Y, Van Beers BE, Soulez G, Poitout V, Tang A. Early detection of liver steatosis by magnetic resonance imaging in rats infused with glucose and intralipid solutions and correlation to insulin levels. Metabolism: Clinical and Experimental. 62: 1850-7. PMID 24035445 DOI: 10.1016/J.Metabol.2013.08.003 |
0.327 |
|
| 2013 |
Mancini AD, Poitout V. [Membrane fatty acid receptors in the β-cell: novel therapeutic targets for type 2 diabetes]. MéDecine Sciences : M/S. 29: 715-21. PMID 24005625 DOI: 10.1051/Medsci/2013298009 |
0.605 |
|
| 2013 |
Fergusson G, Ethier M, Zarrouki B, Fontés G, Poitout V. A model of chronic nutrient infusion in the rat Journal of Visualized Experiments : Jove. PMID 23979115 DOI: 10.3791/50267 |
0.505 |
|
| 2013 |
Semache M, Zarrouki B, Fontés G, Fogarty S, Kikani C, Chawki MB, Rutter J, Poitout V. Per-Arnt-Sim kinase regulates pancreatic duodenal homeobox-1 protein stability via phosphorylation of glycogen synthase kinase 3β in pancreatic β-cells. The Journal of Biological Chemistry. 288: 24825-33. PMID 23853095 DOI: 10.1074/Jbc.M113.495945 |
0.516 |
|
| 2013 |
Sabatini PV, Krentz NA, Zarrouki B, Westwell-Roper CY, Nian C, Uy RA, Shapiro AM, Poitout V, Lynn FC. Npas4 is a novel activity-regulated cytoprotective factor in pancreatic β-cells. Diabetes. 62: 2808-20. PMID 23656887 DOI: 10.2337/Db12-1527 |
0.493 |
|
| 2013 |
Mancini AD, Poitout V. The fatty acid receptor FFA1/GPR40 a decade later: how much do we know? Trends in Endocrinology and Metabolism: Tem. 24: 398-407. PMID 23631851 DOI: 10.1016/J.Tem.2013.03.003 |
0.604 |
|
| 2013 |
Honoré JC, Kooli A, Hamel D, Alquier T, Rivera JC, Quiniou C, Hou X, Kermorvant-Duchemin E, Hardy P, Poitout V, Chemtob S. Fatty acid receptor Gpr40 mediates neuromicrovascular degeneration induced by transarachidonic acids in rodents. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 954-61. PMID 23520164 DOI: 10.1161/Atvbaha.112.300943 |
0.335 |
|
| 2013 |
Lamontagne J, Jalbert-Arsenault E, Pepin E, Peyot ML, Ruderman NB, Nolan CJ, Joly E, Madiraju SR, Poitout V, Prentki M. Pioglitazone acutely reduces energy metabolism and insulin secretion in rats. Diabetes. 62: 2122-9. PMID 23378607 DOI: 10.2337/Db12-0428 |
0.581 |
|
| 2013 |
Wauquier F, Philippe C, Léotoing L, Mercier S, Davicco MJ, Lebecque P, Guicheux J, Pilet P, Miot-Noirault E, Poitout V, Alquier T, Coxam V, Wittrant Y. The free fatty acid receptor G protein-coupled receptor 40 (GPR40) protects from bone loss through inhibition of osteoclast differentiation. The Journal of Biological Chemistry. 288: 6542-51. PMID 23335512 DOI: 10.1074/Jbc.M112.429084 |
0.301 |
|
| 2013 |
Semache M, Fontés G, Fogarty S, Kikani C, Rutter J, Poitout V. PAS Kinase Regulates PDX-1 Protein Stability Via Phosphorylation of GSK3β in Pancreatic Beta Cells Canadian Journal of Diabetes. 37: S59. DOI: 10.1016/J.Jcjd.2013.08.177 |
0.32 |
|
| 2013 |
Bergeron V, Vivot K, Ghislain J, Poitout V. Role of Protein Kinase D 1 in Pancreatic Beta Cells Canadian Journal of Diabetes. 37: S58-S59. DOI: 10.1016/J.Jcjd.2013.08.175 |
0.315 |
|
| 2013 |
benterki I, Fontes G, Berthiaume Y, Poitout V. The ΔF508 Gene Mutation of Cystic Fibrosis Transmembrane Regulator Protein Leads to a Progressive Decline of Beta-Cell Function in Mice Carrying This Mutation Canadian Journal of Diabetes. 37: S57. DOI: 10.1016/J.Jcjd.2013.08.169 |
0.489 |
|
| 2013 |
Zarrouki B, Benterki I, Fontés G, Peyot M, Seda O, Prentki M, Poitout V. Epidermal Growth Factor Signalling Promotes Pancreatic Beta-Cell Proliferation In Response to Nutrient Excess tn Rats Through MTOR And FOXM1 Canadian Journal of Diabetes. 37: S8. DOI: 10.1016/J.Jcjd.2013.08.019 |
0.344 |
|
| 2012 |
Poitout V. Lipotoxicity impairs incretin signalling. Diabetologia. 56: 231-3. PMID 23188391 DOI: 10.1007/S00125-012-2788-6 |
0.544 |
|
| 2012 |
Ferdaoussi M, Bergeron V, Zarrouki B, Kolic J, Cantley J, Fielitz J, Olson EN, Prentki M, Biden T, MacDonald PE, Poitout V. G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1. Diabetologia. 55: 2682-92. PMID 22820510 DOI: 10.1007/S00125-012-2650-X |
0.527 |
|
| 2012 |
Schrimpe-Rutledge AC, Fontès G, Gritsenko MA, Norbeck AD, Anderson DJ, Waters KM, Adkins JN, Smith RD, Poitout V, Metz TO. Discovery of novel glucose-regulated proteins in isolated human pancreatic islets using LC-MS/MS-based proteomics. Journal of Proteome Research. 11: 3520-32. PMID 22578083 DOI: 10.1021/Pr3002996 |
0.559 |
|
| 2012 |
Amyot J, Semache M, Ferdaoussi M, Fontés G, Poitout V. Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling. Plos One. 7: e36200. PMID 22558381 DOI: 10.1371/Journal.Pone.0036200 |
0.773 |
|
| 2012 |
Kebede M, Ferdaoussi M, Mancini A, Alquier T, Kulkarni RN, Walker MD, Poitout V. Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1. Proceedings of the National Academy of Sciences of the United States of America. 109: 2376-81. PMID 22308370 DOI: 10.1073/Pnas.1114350109 |
0.574 |
|
| 2012 |
Ferdaoussi M, Bergeron V, Kebede M, Mancini A, Alquier T, Poitout V. Free Fatty Acid Receptor 1: A New Drug Target for Type 2 Diabetes? Canadian Journal of Diabetes. 36: 275-280. DOI: 10.1016/J.Jcjd.2012.08.002 |
0.551 |
|
| 2011 |
Semplici F, Vaxillaire M, Fogarty S, Semache M, Bonnefond A, Fontés G, Philippe J, Meur G, Diraison F, Sessions RB, Rutter J, Poitout V, Froguel P, Rutter GA. Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion. The Journal of Biological Chemistry. 286: 44005-14. PMID 22065581 DOI: 10.1074/Jbc.M111.254995 |
0.556 |
|
| 2011 |
Amyot J, Benterki I, Fontés G, Hagman DK, Ferdaoussi M, Teodoro T, Volchuk A, Joly É, Poitout V. Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression. Journal of Molecular Endocrinology. 47: 273-83. PMID 21821716 DOI: 10.1530/Jme-11-0016 |
0.79 |
|
| 2010 |
Fontés G, Zarrouki B, Hagman DK, Latour MG, Semache M, Roskens V, Moore PC, Prentki M, Rhodes CJ, Jetton TL, Poitout V. Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass Diabetologia. 53: 2369-2379. PMID 20628728 DOI: 10.1007/S00125-010-1850-5 |
0.58 |
|
| 2010 |
Fontés G, Hagman DK, Latour MG, Semache M, Poitout V. Lack of preservation of insulin gene expression by a glucagon-like peptide 1 agonist or a dipeptidyl peptidase 4 inhibitor in an in vivo model of glucolipotoxicity. Diabetes Research and Clinical Practice. 87: 322-8. PMID 20092903 DOI: 10.1016/J.Diabres.2009.12.020 |
0.618 |
|
| 2010 |
Chen J, Fontes G, Saxena G, Poitout V, Shalev A. Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death. Diabetes. 59: 440-7. PMID 19875615 DOI: 10.2337/Db09-0949 |
0.429 |
|
| 2010 |
Poitout V, Amyot J, Semache M, Zarrouki B, Hagman D, Fontés G. Glucolipotoxicity of the pancreatic beta cell. Biochimica Et Biophysica Acta. 1801: 289-98. PMID 19715772 DOI: 10.1016/S0003-4266(04)95628-4 |
0.812 |
|
| 2009 |
Kebede MA, Alquier T, Latour MG, Poitout V. Lipid receptors and islet function: therapeutic implications? Diabetes, Obesity & Metabolism. 11: 10-20. PMID 19817784 DOI: 10.1111/J.1463-1326.2009.01114.X |
0.512 |
|
| 2009 |
Alquier T, Peyot ML, Latour MG, Kebede M, Sorensen CM, Gesta S, Ronald Kahn C, Smith RD, Jetton TL, Metz TO, Prentki M, Poitout V. Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets. Diabetes. 58: 2607-15. PMID 19720802 DOI: 10.2337/Db09-0362 |
0.609 |
|
| 2009 |
Fontés G, Semache M, Hagman DK, Tremblay C, Shah R, Rhodes CJ, Rutter J, Poitout V. Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells. Diabetes. 58: 2048-58. PMID 19502418 DOI: 10.2337/Db08-0579 |
0.558 |
|
| 2009 |
Lamontagne J, Pepin E, Peyot ML, Joly E, Ruderman NB, Poitout V, Madiraju SR, Nolan CJ, Prentki M. Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations. Endocrinology. 150: 3465-74. PMID 19406947 DOI: 10.1210/En.2008-1557 |
0.574 |
|
| 2009 |
Alquier T, Poitout V. GPR40: good cop, bad cop? Diabetes. 58: 1035-6. PMID 19401432 DOI: 10.2337/Db09-0215 |
0.595 |
|
| 2009 |
Peyot ML, Guay C, Latour MG, Lamontagne J, Lussier R, Pineda M, Ruderman NB, Haemmerle G, Zechner R, Joly E, Madiraju SR, Poitout V, Prentki M. Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion. The Journal of Biological Chemistry. 284: 16848-59. PMID 19389712 DOI: 10.1074/Jbc.M109.006650 |
0.624 |
|
| 2009 |
Guo S, Burnette R, Zhao L, Vanderford NL, Poitout V, Hagman DK, Henderson E, Ozcan S, Wadzinski BE, Stein R. The stability and transactivation potential of the mammalian MafA transcription factor are regulated by serine 65 phosphorylation. The Journal of Biological Chemistry. 284: 759-65. PMID 19004825 DOI: 10.1074/Jbc.M806314200 |
0.392 |
|
| 2009 |
Lamontagne J, Pepin É, Peyot M, Joly É, Poitout V, Madiraju S, Nolan C, Prentki M. Pioglitazone acutely causes metabolic deceleration of the pancreatic ß-cell and reduces insulin secretion at submaximal glucose concentrations via AMP-kinase Canadian Journal of Diabetes. 33: 239-240. DOI: 10.1016/S1499-2671(09)33144-5 |
0.556 |
|
| 2008 |
Poitout V. Glucolipotoxicity of the pancreatic beta-cell: myth or reality? Biochemical Society Transactions. 36: 901-4. PMID 18793158 DOI: 10.1042/Bst0360901 |
0.647 |
|
| 2008 |
Kebede M, Alquier T, Latour MG, Semache M, Tremblay C, Poitout V. The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding. Diabetes. 57: 2432-7. PMID 18559658 DOI: 10.1016/S1499-2671(08)24147-X |
0.617 |
|
| 2008 |
Poitout V, Robertson RP. Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocrine Reviews. 29: 351-66. PMID 18048763 DOI: 10.1210/Er.2007-0023 |
0.539 |
|
| 2008 |
Hagman DK, Latour MG, Chakrabarti SK, Fontes G, Amyot J, Tremblay C, Semache M, Lausier JA, Roskens V, Mirmira RG, Jetton TL, Poitout V. Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets. Diabetes. 57: 424-31. PMID 17991758 DOI: 10.2337/Db07-1285 |
0.812 |
|
| 2008 |
Poitout V. Phospholipid hydrolysis and insulin secretion: a step toward solving the Rubik's cube. American Journal of Physiology. Endocrinology and Metabolism. 294: E214-6. PMID 17925452 DOI: 10.1152/Ajpendo.00638.2007 |
0.57 |
|
| 2008 |
Amyot J, Hagman D, Fontès G, Poitout V. A Role for ER Stress and JNK in Fatty Acid Inhibition of the Insulin Gene Canadian Journal of Diabetes. 32: 338. DOI: 10.1016/S1499-2671(08)24155-9 |
0.781 |
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| 2008 |
FontÉs G, Semache M, Hagman D, Rutter J, Poitout V. PAS Kinase Mediates Palmitate Inhibition of Insulin Gene Expression in Pancreatic Beta-Cells Canadian Journal of Diabetes. 32: 303. DOI: 10.1016/S1499-2671(08)24021-9 |
0.546 |
|
| 2007 |
Madiraju SR, Poitout V. G protein-coupled receptors and insulin secretion: 119 and counting. Endocrinology. 148: 2598-600. PMID 17507578 DOI: 10.1210/En.2007-0336 |
0.601 |
|
| 2007 |
Latour MG, Alquier T, Oseid E, Tremblay C, Jetton TL, Luo J, Lin DC, Poitout V. GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo. Diabetes. 56: 1087-94. PMID 17395749 DOI: 10.2337/Db06-1532 |
0.631 |
|
| 2006 |
Metz TO, Jacobs JM, Gritsenko MA, Fontès G, Qian WJ, Camp DG, Poitout V, Smith RD. Characterization of the human pancreatic islet proteome by two-dimensional LC/MS/MS. Journal of Proteome Research. 5: 3345-54. PMID 17137336 DOI: 10.1021/Pr060322N |
0.389 |
|
| 2006 |
Poitout V, Hagman D, Stein R, Artner I, Robertson RP, Harmon JS. Regulation of the insulin gene by glucose and fatty acids. The Journal of Nutrition. 136: 873-6. PMID 16549443 DOI: 10.1093/Jn/136.4.873 |
0.651 |
|
| 2005 |
Hagman DK, Hays LB, Parazzoli SD, Poitout V. Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans. The Journal of Biological Chemistry. 280: 32413-8. PMID 15944145 DOI: 10.1074/Jbc.M506000200 |
0.627 |
|
| 2005 |
Bihan H, Rouault C, Reach G, Poitout V, Staels B, Guerre-Millo M. Pancreatic islet response to hyperglycemia is dependent on peroxisome proliferator-activated receptor alpha (PPARalpha). Febs Letters. 579: 2284-8. PMID 15848159 DOI: 10.1016/J.Febslet.2005.03.020 |
0.594 |
|
| 2005 |
Zhao L, Guo M, Matsuoka TA, Hagman DK, Parazzoli SD, Poitout V, Stein R. The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription. The Journal of Biological Chemistry. 280: 11887-94. PMID 15665000 DOI: 10.1074/Jbc.M409475200 |
0.587 |
|
| 2005 |
Pino MF, Ye DZ, Linning KD, Green CD, Wicksteed B, Poitout V, Olson LK. Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic beta-cells via reduced nuclear factor binding to the A5/core and Z element. Molecular Endocrinology (Baltimore, Md.). 19: 1343-60. PMID 15650027 DOI: 10.1210/Me.2003-0493 |
0.587 |
|
| 2004 |
Moore PC, Ugas MA, Hagman DK, Parazzoli SD, Poitout V. Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion. Diabetes. 53: 2610-6. PMID 15448091 DOI: 10.2337/Diabetes.53.10.2610 |
0.581 |
|
| 2004 |
Roduit R, Nolan C, Alarcon C, Moore P, Barbeau A, Delghingaro-Augusto V, Przybykowski E, Morin J, Massé F, Massie B, Ruderman N, Rhodes C, Poitout V, Prentki M. A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. Diabetes. 53: 1007-19. PMID 15047616 DOI: 10.2337/Diabetes.53.4.1007 |
0.598 |
|
| 2004 |
Robertson RP, Harmon J, Tran PO, Poitout V. Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes. 53: S119-24. PMID 14749276 DOI: 10.2337/Diabetes.53.2007.S119 |
0.45 |
|
| 2003 |
Parker SM, Moore PC, Johnson LM, Poitout V. Palmitate potentiation of glucose-induced insulin release: a study using 2-bromopalmitate. Metabolism: Clinical and Experimental. 52: 1367-71. PMID 14564691 DOI: 10.1016/S0026-0495(03)00279-8 |
0.6 |
|
| 2003 |
Poitout V. The ins and outs of fatty acids on the pancreatic beta cell. Trends in Endocrinology and Metabolism: Tem. 14: 201-3. PMID 12826323 DOI: 10.1016/S1043-2760(03)00086-9 |
0.525 |
|
| 2003 |
Kelpe CL, Moore PC, Parazzoli SD, Wicksteed B, Rhodes CJ, Poitout V. Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. The Journal of Biological Chemistry. 278: 30015-21. PMID 12771145 DOI: 10.1074/Jbc.M302548200 |
0.614 |
|
| 2003 |
Yaekura K, Julyan R, Wicksteed BL, Hays LB, Alarcon C, Sommers S, Poitout V, Baskin DG, Wang Y, Philipson LH, Rhodes CJ. Insulin secretory deficiency and glucose intolerance in Rab3A null mice. The Journal of Biological Chemistry. 278: 9715-21. PMID 12510060 DOI: 10.1074/Jbc.M211352200 |
0.623 |
|
| 2002 |
Guest PC, Abdel-Halim SM, Gross DJ, Clark A, Poitout V, Amaria R, Ostenson CG, Hutton JC. Proinsulin processing in the diabetic Goto-Kakizaki rat. The Journal of Endocrinology. 175: 637-47. PMID 12475375 DOI: 10.1677/Joe.0.1750637 |
0.556 |
|
| 2002 |
Kelpe CL, Johnson LM, Poitout V. Increasing triglyceride synthesis inhibits glucose-induced insulin secretion in isolated rat islets of langerhans: a study using adenoviral expression of diacylglycerol acyltransferase. Endocrinology. 143: 3326-32. PMID 12193544 DOI: 10.1210/En.2002-220402 |
0.625 |
|
| 2002 |
Briaud I, Kelpe CL, Johnson LM, Tran PO, Poitout V. Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic rats. Diabetes. 51: 662-8. PMID 11872664 DOI: 10.2337/Diabetes.51.3.662 |
0.61 |
|
| 2002 |
Poitout V, Robertson RP. Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity. Endocrinology. 143: 339-42. PMID 11796484 DOI: 10.1210/Endo.143.2.8623 |
0.626 |
|
| 2001 |
Guerre-Millo M, Rouault C, Poulain P, André J, Poitout V, Peters JM, Gonzalez FJ, Fruchart JC, Reach G, Staels B. PPAR-alpha-null mice are protected from high-fat diet-induced insulin resistance. Diabetes. 50: 2809-14. PMID 11723064 DOI: 10.2337/Diabetes.50.12.2809 |
0.503 |
|
| 2001 |
Harmon JS, Gleason CE, Tanaka Y, Poitout V, Robertson RP. Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats. Diabetes. 50: 2481-6. PMID 11679425 DOI: 10.2337/Diabetes.50.11.2481 |
0.561 |
|
| 2001 |
Briaud I, Harmon JS, Kelpe CL, Segu VB, Poitout V. Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids. Diabetes. 50: 315-21. PMID 11272142 DOI: 10.2337/Diabetes.50.2.315 |
0.599 |
|
| 2000 |
Briaud I, Rouault C, Bailbé D, Portha B, Reach G, Poitout V. Glucose-induced insulin mRNA accumulation is impaired in islets from neonatal streptozotocin-treated rats. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme. 32: 103-6. PMID 10786928 DOI: 10.1055/S-2007-978599 |
0.612 |
|
| 2000 |
Jacqueminet S, Briaud I, Rouault C, Reach G, Poitout V. Inhibition of insulin gene expression by long-term exposure of pancreatic beta cells to palmitate is dependent on the presence of a stimulatory glucose concentration. Metabolism: Clinical and Experimental. 49: 532-6. PMID 10778881 DOI: 10.1016/S0026-0495(00)80021-9 |
0.625 |
|
| 2000 |
Briaud I, Rouault C, Bailbé D, Portha B, Reach G, Poitout V. Glucose-induced insulin mRNA accumulation is impaired in islets from neonatal streptozotocin-treated rats. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme. 32: 53-6. PMID 10741685 DOI: 10.1055/s-2007-978588 |
0.54 |
|
| 2000 |
Briaud I, Harmon JS, Kelpe CL, Segu VB, Poitout V. Lipotoxicity of the pancreatic beta-cell is associated with a glucose-dependent, substrate-driven increase in esterification of fatty acids into neutral lipids Diabetes Research and Clinical Practice. 50: 147. DOI: 10.1016/S0168-8227(00)81954-3 |
0.474 |
|
| 1999 |
Tran PO, Gleason CE, Poitout V, Robertson RP. Prostaglandin E(2) mediates inhibition of insulin secretion by interleukin-1beta. The Journal of Biological Chemistry. 274: 31245-8. PMID 10531320 DOI: 10.1074/Jbc.274.44.31245 |
0.459 |
|
| 1999 |
Briaud I, Rouault C, Reach G, Poitout V. Long-term exposure of isolated rat islets of Langerhans to supraphysiologic glucose concentrations decreases insulin mRNA levels. Metabolism: Clinical and Experimental. 48: 319-23. PMID 10094107 DOI: 10.1016/S0026-0495(99)90079-3 |
0.568 |
|
| 1999 |
BENES C, POITOUT V, MARIE J, MARTIN-PEREZ J, ROISIN M, FAGARD R. Mode of regulation of the extracellular signal-regulated kinases in the pancreatic β-cell line MIN6 and their implication in the regulation of insulin gene transcription Biochemical Journal. 340: 219-225. DOI: 10.1042/Bj3400219 |
0.529 |
|
| 1998 |
Poitout V, Rouault C, Guerre-Millo ML, Briaud I, Reach GR. Inhibition of Insulin Secretion by Leptin in Normal Rodent Islets of Langerhans. Endocrinology. 139: 822-826. PMID 28200464 DOI: 10.1210/Endo.139.3.5812 |
0.601 |
|
| 1998 |
Reach G, Darquy S, Poitout V. [Use of islet cells in cell therapy]. Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine. 5: 88-96. PMID 9577883 DOI: 10.1016/S1246-7820(98)80114-6 |
0.517 |
|
| 1998 |
Olson LK, Qian J, Poitout V. Glucose rapidly and reversibly decreases INS-1 cell insulin gene transcription via decrements in STF-1 and C1 activator transcription factor activity. Molecular Endocrinology (Baltimore, Md.). 12: 207-19. PMID 9482663 DOI: 10.1210/Mend.12.2.0066 |
0.615 |
|
| 1997 |
Moran A, Zhang HJ, Olson LK, Harmon JS, Poitout V, Robertson RP. Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15. The Journal of Clinical Investigation. 99: 534-9. PMID 9022089 DOI: 10.1172/Jci119190 |
0.634 |
|
| 1997 |
Gupta V, Wahoff DC, Rooney DP, Poitout V, Sutherland DE, Kendall DM, Robertson RP. The defective glucagon response from transplanted intrahepatic pancreatic islets during hypoglycemia is transplantation site-determined. Diabetes. 46: 28-33. PMID 8971077 DOI: 10.2337/Diab.46.1.28 |
0.308 |
|
| 1996 |
Poitout V, Olson LK, Robertson RP. Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator. The Journal of Clinical Investigation. 97: 1041-6. PMID 8613527 DOI: 10.1172/Jci118496 |
0.595 |
|
| 1995 |
Kendall DM, Poitout V, Olson LK, Sorenson RL, Robertson RP. Somatostatin coordinately regulates glucagon gene expression and exocytosis in HIT-T15 cells. The Journal of Clinical Investigation. 96: 2496-502. PMID 7593640 DOI: 10.1172/Jci118309 |
0.489 |
|
| 1995 |
Poitout V, Stout LE, Armstrong MB, Walseth TF, Sorenson RL, Robertson RP. Morphological and functional characterization of beta TC-6 cells--an insulin-secreting cell line derived from transgenic mice. Diabetes. 44: 306-13. PMID 7533732 DOI: 10.2337/Diab.44.3.306 |
0.601 |
|
| 1995 |
Pueyo M, Darquy S, Arbet-Engels C, Poitout V, Dl Maria S, Gangnerau M, Reach G. A Method for Obtaining Monodispersed Cells from Isolated Porcine Islets of Langerhans The International Journal of Artificial Organs. 18: 34-38. DOI: 10.1177/039139889501800108 |
0.376 |
|
| 1994 |
Poitout V, Moatti-Sirat D, Reach G. Development of a glucose sensor for glucose monitoring in man: the disposable implant concept. Clinical Materials. 15: 241-6. PMID 10172070 DOI: 10.1016/0267-6605(94)90052-3 |
0.448 |
|
| 1994 |
Arbet-Engels C, Darquy S, Capron F, Pueyo ME, Dimaria S, Poitout V, Reach G. A one-step, operator-independent method for isolating islets of Langerhans from the porcine pancreas. Artificial Organs. 18: 570-5. PMID 7993192 DOI: 10.1111/J.1525-1594.1994.Tb03381.X |
0.372 |
|
| 1994 |
Moatti-Sirat D, Poitout V, Thomé V, Gangnerau MN, Zhang Y, Hu Y, Wilson GS, Lemonnier F, Klein JC, Reach G. Reduction of acetaminophen interference in glucose sensors by a composite Nafion membrane: demonstration in rats and man. Diabetologia. 37: 610-6. PMID 7926347 DOI: 10.1007/Bf00403381 |
0.337 |
|
| 1993 |
Poitout V, Moatti-Sirat D, Reach G, Zhang Y, Wilson GS, Lemonnier F, Klein JC. A glucose monitoring system for on line estimation in man of blood glucose concentration using a miniaturized glucose sensor implanted in the subcutaneous tissue and a wearable control unit. Diabetologia. 36: 658-63. PMID 8359584 DOI: 10.1007/Bf00404077 |
0.43 |
|
| 1993 |
Poitout V, Moatti-Sirat D, Reach G. Calibration in dogs of a subcutaneous miniaturized glucose sensor using a glucose meter for blood glucose determination. Biosensors & Bioelectronics. 7: 587-92. PMID 1457093 DOI: 10.1016/0956-5663(92)85010-8 |
0.431 |
|
| 1992 |
Wilson GS, Zhang Y, Reach G, Moatti-Sirat D, Poitout V, Thévenot DR, Lemonnier F, Klein JC. Progress toward the development of an implantable sensor for glucose. Clinical Chemistry. 38: 1613-7. PMID 1525989 DOI: 10.1093/Clinchem/38.9.1613 |
0.383 |
|
| 1992 |
Moatti-Sirat D, Capron F, Poitout V, Reach G, Bindra DS, Zhang Y, Wilson GS, Thévenot DR. Towards continuous glucose monitoring: in vivo evaluation of a miniaturized glucose sensor implanted for several days in rat subcutaneous tissue. Diabetologia. 35: 224-30. PMID 1373393 DOI: 10.1007/Bf00400921 |
0.39 |
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