| Year |
Citation |
Score |
| 2022 |
Ramdas B, Yuen LD, Palam LR, Patel R, Pasupuleti SK, Jideonwo V, Zhang J, Maguire C, Wong E, Kanumuri R, Zhang C, Sandusky G, Chan RJ, Zhang C, Stieglitz E, et al. Inhibition of BTK and PI3Kδ impairs the development of Human JMML Stem and Progenitor cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 35443935 DOI: 10.1016/j.ymthe.2022.04.009 |
0.395 |
|
| 2018 |
Tarnawsky SP, Yu WM, Qu CK, Chan RJ, Yoder MC. Hematopoietic-restricted Ptpn11E76K reveals indolent MPN progression in mice. Oncotarget. 9: 21831-21843. PMID 29774106 DOI: 10.18632/Oncotarget.25073 |
0.427 |
|
| 2018 |
Deng L, Richine BM, Virts EL, Jideonwo-Auman VN, Chan RJ, Kapur R. Rapid development of myeloproliferative neoplasm in mice withmutation and haploinsufficient for. Oncotarget. 9: 6055-6061. PMID 29464054 DOI: 10.18632/Oncotarget.23680 |
0.394 |
|
| 2018 |
Patel R, Ramdas B, Deng L, Jideonwo-Auman V, Chan RJ, Kapur R. Combined Pharmacological Inhibition of Bruton's Tyrosine Kinase (BTK) and Phosphoinositide 3-Kinase (PI3K) p110δ Rescues Monocytosis, Thrombocytopenia, and Splenomegaly in a Genetic Mouse Model for JMML Blood. 132: 2623-2623. DOI: 10.1182/Blood-2018-99-118802 |
0.515 |
|
| 2017 |
Deng L, Chan RJ. Cleaning up the environment in juvenile myelomonocytic leukemia. Translational Cancer Research. 6: S36-S38. PMID 31649860 DOI: 10.21037/Tcr.2017.02.06 |
0.371 |
|
| 2017 |
Deng L, Virts EL, Kapur R, Chan RJ. Pharmacologic inhibition of PI3K p110δ in mutant Shp2E76K-expressing mice. Oncotarget. 8: 84776-84781. PMID 29156682 DOI: 10.18632/Oncotarget.21455 |
0.433 |
|
| 2017 |
Tarnawsky SP, Yoshimoto M, Deng L, Chan RJ, Yoder MC. Yolk Sac Erythromyeloid Progenitors Expressing Gain Of Function PTPN11 Have Functional Features Of JMML But Are Not Sufficient To Cause Disease In Mice. Developmental Dynamics : An Official Publication of the American Association of Anatomists. PMID 28975680 DOI: 10.1002/Dvdy.24598 |
0.396 |
|
| 2017 |
Tarnawsky SP, Chan RJ, Yoder MC. Mice expressing KrasG12D in hematopoietic multipotent progenitor cells develop neonatal myeloid leukemia. The Journal of Clinical Investigation. PMID 28846072 DOI: 10.1172/Jci94031 |
0.419 |
|
| 2017 |
O'Leary HA, Capitano M, Cooper S, Mantel C, Boswell HS, Kapur R, Ramdas B, Chan R, Deng L, Qu CK, Broxmeyer HE. DPP4 truncated GM-CSF & IL-3 manifest distinct receptor binding & regulatory functions compared to their full length forms. Leukemia. PMID 28344320 DOI: 10.1038/Leu.2017.98 |
0.348 |
|
| 2016 |
Liu W, Yu WM, Zhang J, Chan RJ, Loh ML, Zhang Z, Qu CK. Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations. Leukemia. PMID 27840422 DOI: 10.1038/Leu.2016.326 |
0.462 |
|
| 2016 |
Ghosh J, Kobayashi M, Ramdas B, Chatterjee A, Ma P, Mali RS, Carlesso N, Liu Y, Plas DR, Chan RJ, Kapur R. S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance. The Journal of Clinical Investigation. PMID 27294524 DOI: 10.1172/Jci84565 |
0.442 |
|
| 2016 |
Richine BM, Virts EL, Bowling JD, Ramdas B, Mali R, Naoye R, Liu Z, Zhang ZY, Boswell HS, Kapur R, Chan RJ. Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia. Leukemia. PMID 27256702 DOI: 10.1038/Leu.2016.131 |
0.387 |
|
| 2016 |
Li XJ, Deng L, Brandt SL, Goodwin CB, Ma P, Yang Z, Mali RS, Liu Z, Kapur R, Serezani CH, Chan RJ. Role of p85α in neutrophil extra- and intracellular reactive oxygen species generation. Oncotarget. PMID 27049833 DOI: 10.18632/Oncotarget.8500 |
0.308 |
|
| 2016 |
Tarnawsky SP, Yoder MC, Chan RJ. PTPN11D61Y/+; Vavcre+ Animals Commonly Succumb to Leukemia Relapse Despite Robust Engraftment of Transplanted Wild-Type Hematopoietic Stem and Progenitor Cells Blood. 128: 496-496. DOI: 10.1182/Blood.V128.22.496.496 |
0.412 |
|
| 2015 |
Chen L, Chen W, Mysliwski M, Serio J, Ropa J, Abulwerdi FA, Chan RJ, Patel JP, Tallman MS, Paietta E, Melnick A, Levine RL, Abdel-Wahab O, Nikolovska-Coleska Z, Muntean AG. Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition. Leukemia. 29: 1290-300. PMID 25650089 DOI: 10.1038/Leu.2015.18 |
0.459 |
|
| 2015 |
Kim H, Huang L, Critser PJ, Yang Z, Chan RJ, Wang L, Carlesso N, Voytik-Harbin SL, Bernstein ID, Yoder MC. Notch ligand Delta-like 1 promotes in vivo vasculogenesis in human cord blood-derived endothelial colony forming cells. Cytotherapy. 17: 579-92. PMID 25559145 DOI: 10.1016/J.Jcyt.2014.12.003 |
0.334 |
|
| 2015 |
Niemeyer CM, Loh ML, Cseh A, Cooper T, Dvorak CC, Chan R, Xicoy B, Germing U, Kojima S, Manabe A, Dworzak M, De Moerloose B, Starý J, Smith OP, Masetti R, et al. Criteria for evaluating response and outcome in clinical trials for children with juvenile myelomonocytic leukemia. Haematologica. 100: 17-22. PMID 25552679 DOI: 10.3324/Haematol.2014.109892 |
0.309 |
|
| 2015 |
Li XJ, Goodwin CB, Nabinger SC, Richine BM, Yang Z, Hanenberg H, Ohnishi H, Matozaki T, Feng GS, Chan RJ. Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst. The Journal of Biological Chemistry. 290: 3894-909. PMID 25538234 DOI: 10.1074/Jbc.M114.614057 |
0.568 |
|
| 2014 |
Chatterjee A, Ghosh J, Ramdas B, Mali RS, Martin H, Kobayashi M, Vemula S, Canela VH, Waskow ER, Visconte V, Tiu RV, Smith CC, Shah N, Bunting KD, Boswell HS, ... ... Chan RJ, et al. Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis. Cell Reports. 9: 1333-48. PMID 25456130 DOI: 10.1016/J.Celrep.2014.10.039 |
0.427 |
|
| 2014 |
Zeng LF, Zhang RY, Yu ZH, Li S, Wu L, Gunawan AM, Lane BS, Mali RS, Li X, Chan RJ, Kapur R, Wells CD, Zhang ZY. Therapeutic potential of targeting the oncogenic SHP2 phosphatase. Journal of Medicinal Chemistry. 57: 6594-609. PMID 25003231 DOI: 10.1021/Jm5006176 |
0.325 |
|
| 2014 |
Goodwin CB, Li XJ, Mali RS, Chan G, Kang M, Liu Z, Vanhaesebroeck B, Neel BG, Loh ML, Lannutti BJ, Kapur R, Chan RJ. PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML. Blood. 123: 2838-42. PMID 24553178 DOI: 10.1182/Blood-2013-10-535104 |
0.443 |
|
| 2014 |
Chen L, Chen W, Mysliwski M, Serio J, Ropa J, Abulwerdi F, Chan RJ, Patel JP, Tallman MS, Paietta EM, Melnick AM, Levine RL, Abdel-Wahab O, Nikolovska-Coleska Z, Muntean AG. Hyperactive Ptpn11 Mutations Alters Leukemic Stem Cell Frequency through Mcl-1 Overexpression Blood. 124: 3565-3565. DOI: 10.1182/Blood.V124.21.3565.3565 |
0.464 |
|
| 2014 |
Tarnawsky SP, Yoshimoto M, Chan G, Neel B, Chan RJ, Yoder MC. HSC-Independent Yolk Sac Progenitors Bear Hallmarks of JMML in a PTPN11D61Y Mouse Model Blood. 124: 3236-3236. DOI: 10.1182/Blood.V124.21.3236.3236 |
0.416 |
|
| 2014 |
Li X, Goodwin C, Yang Z, Nabinger SC, Richine B, Chan G, Hanenberg H, Ohnishi H, Matozaki T, El Benna J, Feng G, Neel B, Chan RJ. Macrophage NADPH Oxidase Activation and ROS Production Is Positively Regulated By Shp2 Phosphatase Function Blood. 124: 1397-1397. DOI: 10.1182/Blood.V124.21.1397.1397 |
0.566 |
|
| 2013 |
Chan RJ, Yoder MC. JMML patient-derived iPSCs induce new hypotheses. Blood. 121: 4815-7. PMID 23766458 DOI: 10.1182/Blood-2013-05-500090 |
0.325 |
|
| 2013 |
Nabinger SC, Li XJ, Ramdas B, He Y, Zhang X, Zeng L, Richine B, Bowling JD, Fukuda S, Goenka S, Liu Z, Feng GS, Yu M, Sandusky GE, Boswell HS, ... ... Chan RJ, et al. The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo. Leukemia. 27: 398-408. PMID 23103841 DOI: 10.1038/leu.2012.308 |
0.575 |
|
| 2013 |
Broxmeyer HE, Etienne-Julan M, Gotoh A, Braun SE, Lu L, Cooper S, Feng GS, Li XJ, Chan RJ. Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on SHP2 phosphatase function. Stem Cells and Development. 22: 998-1006. PMID 23082805 DOI: 10.1089/Scd.2012.0478 |
0.568 |
|
| 2013 |
Goodwin CB, Mali R, Chan G, Neel B, Lannutti B, Kapur R, Chan RJ. Phosphatidylinositol-3-Kinase p110d Uniquely Promotes Gain-Of-Function PTPN11-Induced GM-CSF Hypersensitivity In a Model Of Juvenile Myelomonocytic Leukemia Blood. 122: 3678-3678. DOI: 10.1182/Blood.V122.21.3678.3678 |
0.4 |
|
| 2012 |
Mali RS, Chan R, Kapur R. Targeting SHP2 phosphatase in myeloproliferative neoplasms. Oncotarget. 3: 1049-51. PMID 23165317 DOI: 10.18632/Oncotarget.665 |
0.517 |
|
| 2012 |
Mali RS, Ma P, Zeng LF, Martin H, Ramdas B, He Y, Sims E, Nabinger S, Ghosh J, Sharma N, Munugalavadla V, Chatterjee A, Li S, Sandusky G, Craig AW, ... ... Chan RJ, et al. Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood. 120: 2669-78. PMID 22806893 DOI: 10.1182/Blood-2011-08-375873 |
0.563 |
|
| 2012 |
Nabinger SC, Chan RJ. Shp2 function in hematopoietic stem cell biology and leukemogenesis. Current Opinion in Hematology. 19: 273-9. PMID 22504523 DOI: 10.1097/Moh.0B013E328353C6Bf |
0.402 |
|
| 2012 |
Goodwin CB, Yang Z, Yin F, Yu M, Chan RJ. Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF. Haematologica. 97: 1042-7. PMID 22315502 DOI: 10.3324/Haematol.2011.046896 |
0.423 |
|
| 2012 |
Goodwin CB, Gearinger RL, Mali R, Cerabona D, Chan G, Neel BG, Kapur R, Chan RJ. The PI3K catalytic subunit p110-delta is a crucial mediator of leukemia-associated mutant PTPN11 -induced GM-CSF hypersensitivity F1000research. 3. DOI: 10.7490/F1000Research.1092775.1 |
0.336 |
|
| 2012 |
Chatterjee A, Ghosh J, Ramdas B, Vemula S, Martin H, Mali R, Nabinger SC, Goodwin CB, Boswell HS, Chan RJ, Kapur R. Unraveling a Novel Mechanism of Stat5 Regulation by FAK and Rac1 in Flt3ITD Induced Leukemogenesis Blood. 120: 858-858. DOI: 10.1182/Blood.V120.21.858.858 |
0.499 |
|
| 2012 |
Nabinger SC, Li XJ, Ramdas B, He Y, Zhang X, Richine B, Bowling J, Fukuda S, Goenka S, Liu Z, Feng G, Yu M, Sandusky G, Boswell HS, Zhang Z, ... ... Chan RJ, et al. The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Malignant Disease in Vivo and Co-Localizes with Nuclear Phospho-STAT5 in FLT3-ITD-Expressing Leukemic Cells. Blood. 120: 2420-2420. DOI: 10.1182/Blood.V120.21.2420.2420 |
0.615 |
|
| 2011 |
Mali RS, Ramdas B, Ma P, Shi J, Munugalavadla V, Sims E, Wei L, Vemula S, Nabinger SC, Goodwin CB, Chan RJ, Traina F, Visconte V, Tiu RV, Lewis TA, et al. Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL. Cancer Cell. 20: 357-69. PMID 21907926 DOI: 10.1016/J.Ccr.2011.07.016 |
0.439 |
|
| 2011 |
Ma P, Mali RS, Munugalavadla V, Krishnan S, Ramdas B, Sims E, Martin H, Ghosh J, Li S, Chan RJ, Krystal G, Craig AW, Takemoto C, Kapur R. The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor. Blood. 118: 3459-69. PMID 21791431 DOI: 10.1182/Blood-2011-04-351809 |
0.458 |
|
| 2011 |
Chen M, Burgin S, Staser K, He Y, Li X, Robinson M, Jiang L, Chan RJ, Ingram D, Clapp DW. Kinase suppressor of Ras (KSR1) modulates multiple kit-ligand-dependent mast cell functions. Experimental Hematology. 39: 969-76. PMID 21726514 DOI: 10.1016/J.Exphem.2011.06.009 |
0.449 |
|
| 2011 |
Yang Z, Chen M, Sitarski SA, Saadatzadeh T, Yin F, Yu M, Yang FC, Chan RJ. Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K. Leukemia Research. 35: 961-4. PMID 21555152 DOI: 10.1016/J.Leukres.2011.04.003 |
0.461 |
|
| 2011 |
Cai S, Wang H, Bailey B, Ernstberger A, Juliar BE, Sinn AL, Chan RJ, Jones DR, Mayo LD, Baluyut AR, Goebel WS, Pollok KE. Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 2195-206. PMID 21487065 DOI: 10.1158/1078-0432.Ccr-10-1959 |
0.307 |
|
| 2011 |
Ranahan WP, Han Z, Smith-Kinnaman W, Nabinger SC, Heller B, Herbert BS, Chan R, Wells CD. The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases. Cancer Research. 71: 2203-11. PMID 21285250 DOI: 10.1158/0008-5472.Can-10-1995 |
0.449 |
|
| 2011 |
Liu S, Yu Z, Yu X, Huang SX, Luo Y, Wu L, Shen W, Yang Z, Wang L, Gunawan AM, Chan RJ, Shen B, Zhang ZY. SHP2 is a target of the immunosuppressant tautomycetin. Chemistry & Biology. 18: 101-10. PMID 21276943 DOI: 10.1016/J.Chembiol.2010.10.015 |
0.387 |
|
| 2011 |
Stevenson DA, Schwarz EL, Carey JC, Viskochil DH, Hanson H, Bauer S, Weng HY, Greene T, Reinker K, Swensen J, Chan RJ, Yang FC, Senbanjo L, Yang Z, Mao R, et al. Bone resorption in syndromes of the Ras/MAPK pathway. Clinical Genetics. 80: 566-73. PMID 21204800 DOI: 10.1111/J.1399-0004.2010.01619.X |
0.314 |
|
| 2011 |
Ma P, Mali R, Zeng L, Martin H, Ramdas B, He Y, Sims E, Ghosh J, Nabinger SC, Li S, Munugalavadla V, Chatterjee A, Sandusky G, Craig A, Bunting KD, ... ... Chan RJ, et al. KIT Induced Myeloproliferative Disease Is Dependent on PI3Kinase and SHP2 Phosphatase: Identification of SHP2 As a Druggable Target for Treating MPD and AML Blood. 118: 868-868. DOI: 10.1182/Blood.V118.21.868.868 |
0.591 |
|
| 2011 |
Cai S, Wang H, Bailey B, Ernstberger A, Juliar BE, Sinn AL, Chan RJ, Jones DR, Mayo LD, Baluyut AR, Goebel WS, Pollok KE. Abstract 2543: Humanized bone-marrow mouse model as a pre-clinical tool to assess therapy-mediated hematotoxicity Cancer Research. 71: 2543-2543. DOI: 10.1158/1538-7445.Am2011-2543 |
0.36 |
|
| 2010 |
Zhang X, He Y, Liu S, Yu Z, Jiang ZX, Yang Z, Dong Y, Nabinger SC, Wu L, Gunawan AM, Wang L, Chan RJ, Zhang ZY. Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). Journal of Medicinal Chemistry. 53: 2482-93. PMID 20170098 DOI: 10.1021/Jm901645U |
0.374 |
|
| 2010 |
Zhou B, He Y, Zhang X, Xu J, Luo Y, Wang Y, Franzblau SG, Yang Z, Chan RJ, Liu Y, Zheng J, Zhang ZY. Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents. Proceedings of the National Academy of Sciences of the United States of America. 107: 4573-8. PMID 20167798 DOI: 10.1073/Pnas.0909133107 |
0.327 |
|
| 2009 |
Yang Z, Kondo T, Voorhorst CS, Nabinger SC, Ndong L, Yin F, Chan EM, Yu M, Würstlin O, Kratz CP, Niemeyer CM, Flotho C, Hashino E, Chan RJ. Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants. Molecular and Cellular Biology. 29: 4376-93. PMID 19528235 DOI: 10.1128/Mcb.01330-08 |
0.406 |
|
| 2009 |
Zhang W, Chan RJ, Chen H, Yang Z, He Y, Zhang X, Luo Y, Yin F, Moh A, Miller LC, Payne RM, Zhang ZY, Fu XY, Shou W. Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia. The Journal of Biological Chemistry. 284: 22353-63. PMID 19509418 DOI: 10.1074/Jbc.M109.020495 |
0.437 |
|
| 2009 |
Nabinger SC, He Y, Yin F, Zhang X, Senbanjo L, Fukuda S, Yu M, Feng G, Zhang Z, Kapur R, Chan RJ. Targeting the Protein Phosphatase, Shp2, Reduces FLT3-ITD-Induced Hyperproliferation of Murine Hematopoietic Progenitors. Blood. 114: 827-827. DOI: 10.1182/Blood.V114.22.827.827 |
0.542 |
|
| 2009 |
Goodwin CB, Yang Z, Vemula S, Yin F, Kapur R, Chan RJ. Genetic Disruption of the PI3K Regulatory Subunit, p85α Partially Normalizes Gain-of-Function PTPN11-Induced Hypersensitivity to GM-CSF in Hematopoietic Progenitors. Blood. 114: 3968-3968. DOI: 10.1182/Blood.V114.22.3968.3968 |
0.41 |
|
| 2008 |
Yang Z, Li Y, Yin F, Chan RJ. Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival. Experimental Hematology. 36: 1285-96. PMID 18640765 DOI: 10.1016/J.Exphem.2008.04.016 |
0.411 |
|
| 2008 |
Kondo T, Sheets PL, Zopf DA, Aloor HL, Cummins TR, Chan RJ, Hashino E. Tlx3 exerts context-dependent transcriptional regulation and promotes neuronal differentiation from embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 5780-5. PMID 18391221 DOI: 10.1073/Pnas.0708704105 |
0.382 |
|
| 2008 |
Munugalavadla V, Sims EC, Chan RJ, Lenz SD, Kapur R. Requirement for p85alpha regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT. Experimental Hematology. 36: 301-8. PMID 18179858 DOI: 10.1016/J.Exphem.2007.11.008 |
0.434 |
|
| 2008 |
Yan J, Chen S, Zhang Y, Li X, Li Y, Wu X, Yuan J, Robling AG, Kapur R, Karpur R, Chan RJ, Yang FC. Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1. Human Molecular Genetics. 17: 936-48. PMID 18089636 DOI: 10.1093/Hmg/Ddm366 |
0.358 |
|
| 2008 |
Yang Z, Kondo T, Voorhorst Cs, Nabinger SC, Ndong L, Yin F, Chan Em, Wurstlin O, Kratz C, Niemeyer CM, Flotho C, Hashino E, Chan R. Increased C-Jun and Reduced GATA2 Expression Promotes Aberrant Monocytic Differentiation and Expansion Induced by Activating PTPN11 Mutants Blood. 112: 3720-3720. DOI: 10.1182/Blood.V112.11.3720.3720 |
0.448 |
|
| 2008 |
Nabinger SC, Fukuda S, Kapur R, Chan R. The Role of Protein Tyrosine Phosphatase, Shp2, in FLT3-ITD-Induced Leukemogenesis. Blood. 112: 1804-1804. DOI: 10.1182/Blood.V112.11.1804.1804 |
0.409 |
|
| 2007 |
Chan EM, Chan RJ, Comer EM, Goulet RJ, Crean CD, Brown ZD, Fruehwald AM, Yang Z, Boswell HS, Nakshatri H, Gabig TG. MOZ and MOZ-CBP cooperate with NF-kappaB to activate transcription from NF-kappaB-dependent promoters. Experimental Hematology. 35: 1782-92. PMID 17920756 DOI: 10.1016/J.Exphem.2007.07.015 |
0.33 |
|
| 2007 |
Munugalavadla V, Sims EC, Borneo J, Chan RJ, Kapur R. Genetic and pharmacologic evidence implicating the p85 alpha, but not p85 beta, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis. Blood. 110: 1612-20. PMID 17483298 DOI: 10.1182/Blood-2006-10-053058 |
0.429 |
|
| 2007 |
Chan RJ, Feng GS. PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase. Blood. 109: 862-7. PMID 17053061 DOI: 10.1182/Blood-2006-07-028829 |
0.531 |
|
| 2007 |
Chan EM, Chan RJ, Comer EM, Goulet RJ, Crean CD, Brown ZD, Fruehwald AM, Yang Z, Boswell HS, Nakshatri H, Gabig TG. MOZ and MOZ-CBP Cooperate with NFκB To Induce Expression of NFκB-Dependent Genes. Blood. 110: 887-887. DOI: 10.1182/Blood.V110.11.887.887 |
0.41 |
|
| 2007 |
Yang Z, Voorhorst CS, Ndong L, Yin F, Kondo T, Hashino E, Chan RJ. The C-Terminal Zinc Finger of GATA2 Is Necessary for Normalization of Aberrant Myelomonocytic Differentiation Induced by Activating PTPN11 Mutations. Blood. 110: 3177-3177. DOI: 10.1182/blood.v110.11.3177.3177 |
0.376 |
|
| 2007 |
Chen S, Yan J, Zhang Y, Li Y, Li X, Yuan J, Eskwick S, Nebesio TD, Robling A, Chan RJ, Yang F. Rac1, but Not Rac2, Mediates Osteoclast Gain-of-Function Induced by Nf1 Haploinsufficiency. Blood. 110: 237-237. DOI: 10.1182/Blood.V110.11.237.237 |
0.347 |
|
| 2006 |
Chan RJ, Li Y, Hass MN, Walter A, Voorhorst CS, Shelley WC, Yang Z, Orschell CM, Yoder MC. Shp-2 heterozygous hematopoietic stem cells have deficient repopulating ability due to diminished self-renewal. Experimental Hematology. 34: 1230-9. PMID 16939816 DOI: 10.1016/J.Exphem.2006.04.017 |
0.382 |
|
| 2006 |
Chan RJ, Hromas R, Yoder MC. The role of Hex in hemangioblast and hematopoietic development. Methods in Molecular Biology (Clifton, N.J.). 330: 123-33. PMID 16846021 DOI: 10.1385/1-59745-036-7:123 |
0.387 |
|
| 2006 |
Zou GM, Chan RJ, Shelley WC, Yoder MC. Reduction of Shp-2 expression by small interfering RNA reduces murine embryonic stem cell-derived in vitro hematopoietic differentiation. Stem Cells (Dayton, Ohio). 24: 587-94. PMID 16269528 DOI: 10.1634/Stemcells.2005-0272 |
0.428 |
|
| 2006 |
Chan R, Voorhorst C, Hass M, Kondo T, Hashino E. Activating PTPN11 mutants aberrantly promote myelomonocytic differentiation Leukemia Research. 30: S3-S4. DOI: 10.1016/S0145-2126(06)80014-7 |
0.337 |
|
| 2005 |
Chan RJ, Leedy MB, Munugalavadla V, Voorhorst CS, Li Y, Yu M, Kapur R. Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor. Blood. 105: 3737-42. PMID 15644411 DOI: 10.1182/Blood-2004-10-4002 |
0.442 |
|
| 2005 |
Li Y, McClintick J, Zhong L, Edenberg HJ, Yoder MC, Chan RJ. Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4. Blood. 105: 635-7. PMID 15358627 DOI: 10.1182/Blood-2004-07-2681 |
0.444 |
|
| 2005 |
Chan RJ, Voorhorst CS, Kondo T, Hashino E. Activating PTPN11 Mutants Promote Myelomonocytic Differentiation Due to Altered Hematopoietic Lineage-Specific Transcription Factor Expression. Blood. 106: 3519-3519. DOI: 10.1182/Blood.V106.11.3519.3519 |
0.45 |
|
| 2005 |
Zou G, Chan RJ, Shelley WC, Yoder MC. 374. Knockdown of Shp-2 Expression by siRNA in Mouse Embryonic Stem Cell Derived EB Cells Affects Their Hematopoietic Development Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.377 |
0.466 |
|
| 2004 |
Chan RJ, Yoder MC. The multiple facets of hematopoietic stem cells. Current Neurovascular Research. 1: 197-206. PMID 16181070 DOI: 10.2174/1567202043362324 |
0.389 |
|
| 2004 |
Zhong L, Li W, Yang Z, Qing K, Tan M, Hansen J, Li Y, Chen L, Chan RJ, Bischof D, Maina N, Weigel-Kelley KA, Zhao W, Larsen SH, Yoder MC, et al. Impaired nuclear transport and uncoating limit recombinant adeno-associated virus 2 vector-mediated transduction of primary murine hematopoietic cells. Human Gene Therapy. 15: 1207-18. PMID 15684697 DOI: 10.1089/Hum.2004.15.1207 |
0.401 |
|
| 2004 |
Zhong L, Chen L, Li Y, Qing K, Weigel-Kelley KA, Chan RJ, Yoder MC, Srivastava A. Self-complementary adeno-associated virus 2 (AAV)-T cell protein tyrosine phosphatase vectors as helper viruses to improve transduction efficiency of conventional single-stranded AAV vectors in vitro and in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 10: 950-7. PMID 15509512 DOI: 10.1016/J.Ymthe.2004.07.018 |
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Chan RJ, You M, Feng GS. Identification of trans-acting factors by electrophoretic mobility shift assay. Methods in Molecular Biology (Clifton, N.J.). 249: 7-20. PMID 14573887 DOI: 10.1385/1-59259-667-3:7 |
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Chan RJ, Li Y, Leedy MB. PTPN11 Mutations E76K, D61V, and D61Y Induce Hypersensitivity of Hematopoietic Progenitors to GM-CSF and IL-3. Blood. 104: 2559-2559. DOI: 10.1182/Blood.V104.11.2559.2559 |
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Chan RJ, Li Y, Shelley C, Yoder MC. Shp-2 Heterozygous Hematopoietic Stem Cells Have Deficient Repopulating Activity Due to a Self-Renewal Defect. Blood. 104: 1690-1690. DOI: 10.1182/Blood.V104.11.1690.1690 |
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Zhong L, Chen L, Li Y, Qing K, Chan RJ, Yoder MC, Rao KS, Srivastava A. 342. Self-Complementary Adeno-Associated Virus 2 (AAV)-T Cell Protein Tyrosine Phosphatase Vector as a Helper-Virus to Improve Transduction Efficiency of Conventional AAV Vectors in vitro and in vivo Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.287 |
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Zhong L, Li W, Yang Z, Maina N, Qing K, Li Y, Chen L, Tan M, Chan RJ, Zhao W, Larsen SH, Yoder MC, Shou W, Srivastava A. 303. Impaired Nuclear Transport and Virus Uncoating Limit Recombinant Adeno-Associated Virus 2 Vector-Mediated Transduction of Primary Murine Hematopoietic Cells|[ast]| Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.245 |
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Chan RJ, Li Y, Zhong L, Yoder MC. 52. Gut Enriched Kruppel-Like Factor (GKLF) Inhibits Differentiation and Induces Self-Renewal of Murine Embryonic Stem Cells Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.05.075 |
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Chan RJ, Johnson SA, Li Y, Yoder MC, Feng GS. A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis. Blood. 102: 2074-80. PMID 12791646 DOI: 10.1182/Blood-2003-04-1171 |
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Xie X, Chan RJ, Johnson SA, Starr M, McCarthy J, Kapur R, Yoder MC. Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs. Blood. 101: 1329-35. PMID 12393382 DOI: 10.1182/Blood-2002-05-1468 |
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Xie X, Chan RJ, Yoder MC. Thrombopoietin acts synergistically with LIF to maintain an undifferentiated state of embryonic stem cells homozygous for a Shp-2 deletion mutation. Febs Letters. 529: 361-4. PMID 12372629 DOI: 10.1016/S0014-5793(02)03400-2 |
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Crabb DW, Stewart MJ, Chan RJ. Dexamethasone represses phorbol ester-, forskolin-, and calcium-stimulated expression of a preproenkephalin A promoter-chloramphenicol acetyltransferase gene via a receptor-mediated mechanism. Brain Research. Molecular Brain Research. 42: 103-8. PMID 8915585 DOI: 10.1016/S0169-328X(96)00119-2 |
0.36 |
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