Pradeep Kota, Ph.D.

2012 Biochemistry & Biophysics University of North Carolina, Chapel Hill, Chapel Hill, NC 
"Pradeep Kota"
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Nikolay Dokholyan grad student 2012 UNC Chapel Hill
 (Structural basis for the function and regulation of the epithelial sodium channel.)
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Shaaya M, Fauser J, Zhurikhina A, et al. (2020) Light-Regulated allosteric switch enables temporal and subcellular control of enzyme activity. Elife. 9
Kota P, Gentzsch M, Dang YL, et al. (2018) The N terminus of α-ENaC mediates ENaC cleavage and activation by furin. The Journal of General Physiology
Wang C, Aleksandrov AA, Yang Z, et al. (2018) Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator. The Journal of Biological Chemistry
Shobair M, Dagliyan O, Kota P, et al. (2015) Gain-of-function mutation W493R in the epithelial sodium channel allosterically reconfigures intersubunit coupling. The Journal of Biological Chemistry
Proctor EA, Kota P, Aleksandrov AA, et al. (2015) Rational Coupled Dynamics Network Manipulation Rescues Disease-Relevant Mutant Cystic Fibrosis Transmembrane Conductance Regulator. Chemical Science (Royal Society of Chemistry : 2010). 6: 1237-1246
Kota P, Buchner G, Chakraborty H, et al. (2014) The N-terminal domain allosterically regulates cleavage and activation of the epithelial sodium channel. The Journal of Biological Chemistry. 289: 23029-42
Thompson PM, Tolbert CE, Shen K, et al. (2014) Identification of an actin binding surface on vinculin that mediates mechanical cell and focal adhesion properties. Structure (London, England : 1993). 22: 697-706
Redler RL, Shirvanyants D, Dagliyan O, et al. (2014) Computational approaches to understanding protein aggregation in neurodegeneration. Journal of Molecular Cell Biology. 6: 104-15
He L, Kota P, Aleksandrov AA, et al. (2014) Correctors of δF508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein (FASEB Journal (2013) 27 (536 -545) DOI:10.1096/fj.12-216119) Faseb Journal. 28: 2737
Chong PA, Kota P, Dokholyan NV, et al. (2013) Dynamics intrinsic to cystic fibrosis transmembrane conductance regulator function and stability. Cold Spring Harbor Perspectives in Medicine. 3: a009522
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