Richard Perham
Affiliations: | Biochemistry | University of Cambridge, Cambridge, England, United Kingdom |
Area:
immunologyWebsite:
http://www.bioc.cam.ac.uk/uto/perham.htmlGoogle:
"Richard Perham"Mean distance: 15.82 (cluster 11)
Cross-listing: Chemistry Tree
Children
Sign in to add trainee| David H. Rowitch | grad student | Cambridge | |
| T. Michael A. Wilson | grad student | University of Cambridge and MRC (Plant Biology Tree) | |
| Sheena Radford | grad student | 1987 | Cambridge (Physics Tree) |
| Nigel Scrutton | grad student | 1988 | Cambridge (Crystallography Tree) |
| Alan Berry | post-doc | 1985-1987 | Cambridge (Chemistry Tree) |
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Publications
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| Jones DD, Perham RN. (2008) The role of loop and beta-turn residues as structural and functional determinants for the lipoyl domain from the Escherichia coli 2-oxoglutarate dehydrogenase complex. The Biochemical Journal. 409: 357-66 |
| Frank RA, Price AJ, Northrop FD, et al. (2007) Crystal structure of the E1 component of the Escherichia coli 2-oxoglutarate dehydrogenase multienzyme complex. Journal of Molecular Biology. 368: 639-51 |
| McManus E, Luisi BF, Perham RN. (2006) Structure of a putative lipoate protein ligase from Thermoplasma acidophilum and the mechanism of target selection for post-translational modification. Journal of Molecular Biology. 356: 625-37 |
| Frank RA, Titman CM, Pratap JV, et al. (2004) A molecular switch and proton wire synchronize the active sites in thiamine enzymes. Science (New York, N.Y.). 306: 872-6 |
| Brockwell DJ, Paci E, Zinober RC, et al. (2003) Pulling geometry defines the mechanical resistance of a beta-sheet protein. Nature Structural Biology. 10: 731-7 |
| Fries M, Jung HI, Perham RN. (2003) Reaction mechanism of the heterotetrameric (alpha2beta2) E1 component of 2-oxo acid dehydrogenase multienzyme complexes. Biochemistry. 42: 6996-7002 |
| Fries M, Chauhan HJ, Domingo GJ, et al. (2003) Site-directed mutagenesis of a loop at the active site of E1 (alpha2beta2) of the pyruvate dehydrogenase complex. A possible common sequence motif. European Journal of Biochemistry / Febs. 270: 861-70 |
| Perham RN, Jones DD, Chauhan HJ, et al. (2002) Substrate channelling in 2-oxo acid dehydrogenase multienzyme complexes. Biochemical Society Transactions. 30: 47-51 |
| Perham RN. (2000) Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions. Annual Review of Biochemistry. 69: 961-1004 |
| Jones DD, Horne HJ, Reche PA, et al. (2000) Structural determinants of post-translational modification and catalytic specificity for the lipoyl domains of the pyruvate dehydrogenase multienzyme complex of Escherichia coli. Journal of Molecular Biology. 295: 289-306 |