Orly Alter, Ph.D.

1991-1998 Applied Physics Stanford University, Palo Alto, CA 
 1998-2004 Genetics Stanford University, Palo Alto, CA 
 2004-2010 Biomedical Engineering, & Cellular & Molecular Biology University of Texas at Austin, Austin, Texas, U.S.A. 
 2010- Bioengineering, & Scientific Computing & Imaging University of Utah, Salt Lake City, UT 
 2010-2016 Mathematics University of Texas at Austin, Austin, Texas, U.S.A. 
 2011- Human Genetics University of Utah, Salt Lake City, UT 
 2016- Huntsman Cancer University of Utah, Salt Lake City, UT 
genetics, mathematics, physics
"Orly Alter"


Orly Alter is a Utah Science, Technology, and Research associate professor of bioengineering and human genetics at the Scientific Computing and Imaging Institute [1] and the Huntsman Cancer Institute at the University of Utah, the principal investigator of a National Cancer Institute's Physical Sciences in Oncology project [2,3], and the chief technology officer and a co-founder of Eigengene, Inc. [4,5] Alter received her Ph.D. in applied physics at Stanford University and her B.Sc. magna cum laude in physics at Tel Aviv University. Her Ph.D. thesis on "Quantum Measurement of a Single System," which was published by Wiley [6,7,8], is recognized as crucial to gravitational wave detection [9,10,11].

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Yoshihisa Yamamoto grad student 1999 Stanford
 (Impossibility of determining the quantum wavefunction of a single system and a fundamental limit to external force detection)
David Botstein post-doc 2004 Stanford (Cell Biology Tree)
Patrick O. Brown post-doc 2004 Stanford (FlyTree)


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Joel R. Meyerson research assistant 2007 UT Austin
Andrew M. Gross research assistant 2010 UT Austin
Justin A. Drake research assistant 2011 UT Austin
Nicolas M. Bertagnolli research assistant 2014 University of Utah
Larsson Omberg grad student 2007 UT Austin
Kayta Kobayashi grad student 2008 UT Austin
Chaitanya Muralidhara grad student 2010 UT Austin
Sri Priya Ponnapalli grad student 2010 UT Austin
Jason M. Tennessen post-doc 2013 University of Utah (Neurotree)


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Jill S. Barnholtz-Sloan collaborator National Cancer Institute (Epi Tree)
Huanming Yang collaborator Beijing Genomics Institute (Chemistry Tree)
Gene H. Golub collaborator 2007 Stanford (MathTree)
John FX Diffley collaborator 2009 Francis Crick Institute (PombeTree)
Michael Saunders collaborator 2011 Stanford (MathTree)
Charles F. Van Loan collaborator 2011 Cornell (Computer Science Tree)
Cheryl Ann Palmer collaborator 2020 University of Utah (Neurotree)
Carl T. Wittwer collaborator 2020 University of Utah (BME Tree)
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Ponnapalli SP, Bradley MW, Devine K, et al. (2020) Retrospective clinical trial experimentally validates glioblastoma genome-wide pattern of DNA copy-number alterations predictor of survival. Apl Bioengineering. 4: 026106
Bradley MW, Aiello KA, Ponnapalli SP, et al. (2019) GSVD- and tensor GSVD-uncovered patterns of DNA copy-number alterations predict adenocarcinomas survival in general and in response to platinum. Apl Bioengineering. 3: 036104
Alter O, Yamamoto Y. (2019) Protective measurement of the wave function of a single squeezed harmonic-oscillator state. Physical Review. a, Atomic, Molecular, and Optical Physics. 53: R2911-R2914
Aiello KA, Ponnapalli SP, Alter O. (2018) Mathematically universal and biologically consistent astrocytoma genotype encodes for transformation and predicts survival phenotype. Apl Bioengineering. 2
Aiello KA, Maughan CA, Schomay TE, et al. (2018) Abstract 4267: Patterns of DNA copy-number alterations revealed by the GSVD and tensor GSVD encode for cell transformation and predict survival and response to platinum in adenocarcinomas Cancer Research. 78: 4267-4267
Aiello KA, Alter O. (2016) Platform-Independent Genome-Wide Pattern of DNA Copy-Number Alterations Predicting Astrocytoma Survival and Response to Treatment Revealed by the GSVD Formulated as a Comparative Spectral Decomposition. Plos One. 11: e0164546
Alter O. (2016) Abstract A60: DNA copy-number alterations in primary ovarian serous cystadenocarcinoma encoding for cell transformation and predicting survival and response to platinum therapy throughout the course of the disease. Clinical Cancer Research. 22
Sankaranarayanan P, Schomay TE, Aiello KA, et al. (2015) Tensor GSVD of patient- and platform-matched tumor and normal DNA copy-number profiles uncovers chromosome arm-wide patterns of tumor-exclusive platform-consistent alterations encoding for cell transformation and predicting ovarian cancer survival. Plos One. 10: e0121396
Bertagnolli NM, Drake JA, Tennessen JM, et al. (2013) SVD identifies transcript length distribution functions from DNA microarray data and reveals evolutionary forces globally affecting GBM metabolism. Plos One. 8: e78913
Lee CH, Alpert BO, Sankaranarayanan P, et al. (2012) GSVD comparison of patient-matched normal and tumor aCGH profiles reveals global copy-number alterations predicting glioblastoma multiforme survival. Plos One. 7: e30098
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