Edgar Young, Ph.D.

Molecular Biology and Biochemistry Simon Fraser University, Burnaby, British Columbia, Canada 
biophysics of ion channels
"Edgar Young"
Mean distance: 14.12 (cluster 6)
Cross-listing: Neurotree - Chemistry Tree


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Jeff Gelles grad student Brandeis (Chemistry Tree)
Steven A. Siegelbaum post-doc Simon Fraser (Neurotree)
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Magee KEA, Madden Z, Young EC. (2015) HCN Channel C-Terminal Region Speeds Activation Rates Independently of Autoinhibition Journal of Membrane Biology
Young EC. (2013) Will the real single HCN channel please stand up? Biophysical Journal. 105: 1549-50
Bovero E, Magee KEA, Young EC, et al. (2013) Dispersion of silver nanoparticles into polymer matrix dry adhesives to achieve antibacterial properties, increased adhesion, and optical absorption Macromolecular Reaction Engineering. 7: 624-631
Wong WF, Chan KS, Michaleski MS, et al. (2011) Ligand-binding domain subregions contributing to bimodal agonism in cyclic nucleotide-gated channels. The Journal of General Physiology. 137: 591-603
Wicks NL, Wong T, Sun J, et al. (2011) Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating. Proceedings of the National Academy of Sciences of the United States of America. 108: 609-14
Young EC. (2010) Ion channels regulated by direct binding of cyclic nucleotides Handbook of Cell Signaling, 2/E. 1: 225-231
Chan KS, Young EC. (2009) Bimodal agonism in heteromeric cyclic nucleotide-gated channels. Channels (Austin, Tex.). 3: 427-36
Wicks NL, Chan KS, Madden Z, et al. (2009) Sensitivity of HCN channel deactivation to cAMP is amplified by an S4 mutation combined with activation mode shift. PflüGers Archiv : European Journal of Physiology. 458: 877-89
Zhou L, Olivier NB, Yao H, et al. (2004) A conserved tripeptide in CNG and HCN channels regulates ligand gating by controlling C-terminal oligomerization. Neuron. 44: 823-34
Young EC, Krougliak N. (2004) Distinct structural determinants of efficacy and sensitivity in the ligand-binding domain of cyclic nucleotide-gated channels. The Journal of Biological Chemistry. 279: 3553-62
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