Frank A. Simmen
Affiliations: | Physiology and Biophysics | University of Arkansas for Medical Sciences, United States |
Area:
Oncology, GeneralWebsite:
https://medicine.uams.edu/physiology/faculty/primary-faculty/frank-simmen/Google:
"Frank Simmen"Bio:
https://medicine.uams.edu/physiology/faculty/primary-faculty/frank-simmen/f-a-simmen-lab/
https://www.researchgate.net/profile/Frank-Simmen-2
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Parents
Sign in to add mentorTom Humphreys | grad student | 1981 | University of Hawai'i at Manoa (DevTree) | |
(Characterization of the ribosomal RNA genes in the Hawaiian sea urchin, Tripneustes gratilla) |
Children
Sign in to add traineeSihong Song | grad student | 1996 | UF Gainesville (Chemistry Tree) |
Rijin Xiao | grad student | 2007 | UAMS |
Ahmed Al-Dwairi | grad student | 2013 | UAMS |
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Publications
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Simmen FA, Pabona JMP, Al-Dwairi A, et al. (2023) Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice. International Journal of Molecular Sciences. 24 |
Simmen FA, Alhallak I, Simmen RCM. (2020) Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism. Journal of Molecular Endocrinology. 65: R77-R90 |
Pabona JMP, Burnett AF, Brown DM, et al. (2020) Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells. Reproductive Sciences (Thousand Oaks, Calif.) |
Blossom SJ, Melnyk SB, Simmen FA. (2020) Complex epigenetic patterns in cerebellum generated after developmental exposure to trichloroethylene and/or high fat diet in autoimmune-prone mice. Environmental Science. Processes & Impacts |
Fernandes LM, Al-Dwairi A, Simmen RCM, et al. (2018) Malic Enzyme 1 (ME1) is pro-oncogenic in Apc mice. Scientific Reports. 8: 14268 |
Blossom SJ, Fernandes L, Bai S, et al. (2018) Opposing actions of developmental trichloroethylene and high-fat-diet co-exposure on markers of lipogenesis and inflammation in autoimmune-prone mice. Toxicological Sciences : An Official Journal of the Society of Toxicology |
Montales MT, Melnyk SB, Liu S, et al. (2016) Metabolic history impacts mammary tumor epithelial hierarchy and early drug response in mice. Endocrine-Related Cancer |
Heard ME, Melnyk SB, Simmen FA, et al. (2016) High-Fat Diet Promotion of Endometriosis in an Immunocompetent Mouse Model is Associated with Altered Peripheral and Ectopic Lesion Redox and Inflammatory Status. Endocrinology. en20161092 |
Montales MT, Simmen RC, Ferreira ES, et al. (2015) Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells. Genes & Nutrition. 10: 49 |
Brown AR, Simmen RC, Raj VR, et al. (2015) Krüppel-like Factor 9 (KLF9) prevents colorectal cancer through inhibition of interferon-related signaling. Carcinogenesis |