BETA: Related publications


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Amewu RK, Chadwick J, Hussain A, et al. (2013) Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers. Bioorganic & Medicinal Chemistry. 21: 7392-7
Mok NY, Chadwick J, Kellett KA, et al. (2013) Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design. Journal of Medicinal Chemistry. 56: 1843-52
Copple IM, Mercer AE, Firman J, et al. (2012) Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials. Molecular Medicine (Cambridge, Mass.). 18: 1045-55
Biagini GA, Fisher N, Shone AE, et al. (2012) Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria. Proceedings of the National Academy of Sciences of the United States of America. 109: 8298-303
Sharma R, Lawrenson AS, Fisher NE, et al. (2012) Identification of novel antimalarial chemotypes via chemoinformatic compound selection methods for a high-throughput screening program against the novel malarial target, PfNDH2: increasing hit rate via virtual screening methods. Journal of Medicinal Chemistry. 55: 3144-54
Chadwick J, Amewu RK, Marti F, et al. (2011) Antimalarial mannoxanes: hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action. Chemmedchem. 6: 1357-61
Marti F, Chadwick J, Amewu RK, et al. (2011) Second generation analogues of RKA182: Synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities Medchemcomm. 2: 661-665
Gibbons P, Verissimo E, Araujo NC, et al. (2010) Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity. Journal of Medicinal Chemistry. 53: 8202-6
Barton V, Ward SA, Chadwick J, et al. (2010) Rationale design of biotinylated antimalarial endoperoxide carbon centered radical prodrugs for applications in proteomics. Journal of Medicinal Chemistry. 53: 4555-9
Chadwick J, Jones M, Mercer AE, et al. (2010) Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines. Bioorganic & Medicinal Chemistry. 18: 2586-97
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