William J Lehman

Boston University, Boston, MA, United States 
General Biophysics
"William Jeffrey Lehman" OR "William J Lehman"
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Lionel Israel Rebhun grad student 1966-1969 Princeton (Neurotree)
 (The structural elements responsible for contraction in the ciliate Spirostomum)
Andrew G. Szent-Györgyi post-doc 1969-1972 Brandeis (Cell Biology Tree)
Richard T. Tregear research scientist 1973-1973 Oxford (Physiology Academic Tree)
Kenneth C. Holmes research scientist 1975-1975 MPI for Medical Research (Computational Biology Tree)
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Rynkiewicz MJ, Pavadai E, Lehman W. (2022) Modeling Human Cardiac Thin Filament Structures. Frontiers in Physiology. 13: 932333
Suphamungmee W, Lehman W, Morgan KG. (2022) Functional Remodeling of the Contractile Smooth Muscle Cell Cortex, a Provocative Concept, Supported by Direct Visualization of Cortical Remodeling. Biology. 11
Pavadai E, Rynkiewicz MJ, Yang Z, et al. (2022) Modulation of cardiac thin filament structure by phosphorylated troponin-I analyzed by protein-protein docking and molecular dynamics simulation. Archives of Biochemistry and Biophysics. 725: 109282
Teekakirikul P, Zhu W, Xu X, et al. (2022) Genetic resiliency associated with dominant lethal mutation causing atrial septal defect with high heritability. Cell Reports. Medicine. 3: 100501
Doran MH, Lehman W. (2021) The Central Role of the F-Actin Surface in Myosin Force Generation. Biology. 10
Sewanan LR, Park J, Rynkiewicz MJ, et al. (2021) Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation. The Journal of General Physiology. 153
Lehman W, Pavadai E, Rynkiewicz MJ. (2021) C-terminal troponin-I residues trap tropomyosin in the muscle thin filament blocked-state. Biochemical and Biophysical Research Communications. 551: 27-32
Racca AW, Rynkiewicz MJ, LaFave N, et al. (2020) M8R tropomyosin mutation disrupts actin-binding and filament regulation: the beginning affects the middle and end. The Journal of Biological Chemistry
Doran MH, Pavadai E, Rynkiewicz MJ, et al. (2020) Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments. Biophysical Journal
Pavadai E, Lehman W, Rynkiewicz MJ. (2020) Protein-Protein Docking Reveals Dynamic Interactions of Tropomyosin on Actin Filaments. Biophysical Journal. 119: 75-86
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