William J Lehman

Boston University, Boston, MA, United States 
General Biophysics
"William Jeffrey Lehman" OR "William J Lehman"
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Lionel Israel Rebhun grad student 1966-1969 Princeton (Neurotree)
 (The structural elements responsible for contraction in the ciliate Spirostomum)
Andrew G. Szent-Györgyi post-doc 1969-1972 Brandeis (Cell Biology Tree)
Richard T. Tregear research scientist 1973-1973 Oxford (Physiology Academic Tree)
Kenneth C. Holmes research scientist 1975-1975 MPI (Computational Biology Tree)
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Doran MH, Pavadai E, Rynkiewicz MJ, et al. (2020) Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments. Biophysical Journal
Pavadai E, Lehman W, Rynkiewicz MJ. (2020) Protein-Protein Docking Reveals Dynamic Interactions of Tropomyosin on Actin Filaments. Biophysical Journal. 119: 75-86
Viswanathan MC, Schmidt W, Franz P, et al. (2020) A role for actin flexibility in thin filament-mediated contractile regulation and myopathy. Nature Communications. 11: 2417
Pavadai E, Rynkiewicz MJ, Lehman W. (2020) A Tropomyosin Cable Model on Thin-Filaments Deduced by Protein-Protein Docking Biophysical Journal. 118
Rynkiewicz MJ, Lehman W. (2020) Molecular Dynamics Simulations of Alpha-Beta-Tropomyosin Show Conformational Properties of Heterodimeric Tropomyosin Biophysical Journal. 118
Sundar S, Rynkiewicz MJ, Ghosh A, et al. (2019) Cardiomyopathy Mutation Alters End-to-End Junction of Tropomyosin and Reduces Calcium Sensitivity. Biophysical Journal
Pavadai E, Rynkiewicz MJ, Ghosh A, et al. (2019) Docking Troponin T onto the Tropomyosin Overlapping Domain of Thin Filaments. Biophysical Journal
Geeves MA, Lehrer SS, Lehman W. (2019) The mechanism of thin filament regulation: Models in conflict? The Journal of General Physiology
Janco M, Rynkiewicz MJ, Li L, et al. (2019) Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1. Scientific Reports. 9: 11262
Lehman W, Moore JR, Campbell SG, et al. (2019) The Effect of Tropomyosin Mutations on Actin-Tropomyosin Binding: In Search of Lost Time. Biophysical Journal
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