William J Lehman
Affiliations: | Boston University, Boston, MA, United States |
Area:
General BiophysicsWebsite:
https://www.bumc.bu.edu/busm/profile/william-lehman/Google:
"William Jeffrey Lehman" OR "William J Lehman"Mean distance: (not calculated yet)
Parents
Sign in to add mentorLionel Israel Rebhun | grad student | 1966-1969 | Princeton (Neurotree) | |
(The structural elements responsible for contraction in the ciliate Spirostomum) | ||||
Andrew G. Szent-Györgyi | post-doc | 1969-1972 | Brandeis (Cell Biology Tree) | |
Richard T. Tregear | research scientist | 1973-1973 | Oxford (Physiology Academic Tree) | |
Kenneth C. Holmes | research scientist | 1975-1975 | MPI for Medical Research (Computational Biology Tree) |
Children
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Publications
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Wen J, Campbell S, Moore J, et al. (2025) Screening single nucleotide changes to tropomyosin to identify novel cardiomyopathy mutants. Journal of Molecular and Cellular Cardiology. 203: 82-90 |
Ramachandran B, Rynkiewicz M, Lehman W. (2025) Velcro-binding by cardiac troponin-I traps tropomyosin on actin in a low-energy relaxed state. Biochemical and Biophysical Research Communications. 757: 151595 |
Barry ME, Rynkiewicz MJ, Wen J, et al. (2025) Dual Role of Tropomyosin-R160 in Thin Filament Regulation: Insights into Phosphorylation-Dependent Cardiac Relaxation and Cardiomyopathy Mechanisms. Archives of Biochemistry and Biophysics. 110380 |
Doran MH, Rynkiewicz MJ, Despond E, et al. (2025) The hypertrophic cardiomyopathy-associated A331P actin variant enhances basal contractile activity and elicits resting muscle dysfunction. Iscience. 28: 111816 |
Halder SS, Rynkiewicz MJ, Kim L, et al. (2024) Distinct mechanisms drive divergent phenotypes in hypertrophic and dilated cardiomyopathy associated TPM1 variants. The Journal of Clinical Investigation |
Creso JG, Gokhan I, Rynkiewicz MJ, et al. (2024) In silico and in vitro models reveal the molecular mechanisms of hypocontractility caused by M8R. Frontiers in Physiology. 15: 1452509 |
Rynkiewicz MJ, Childers MC, Karpicheva OE, et al. (2024) Myosin's powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin. The Journal of General Physiology. 156 |
Barry ME, Rynkiewicz MJ, Pavadai E, et al. (2024) Glutamate 139 of tropomyosin is critical for cardiac thin filament blocked-state stabilization. Journal of Molecular and Cellular Cardiology |
Lehman W, Rynkiewicz MJ. (2023) Troponin-I-induced tropomyosin pivoting defines thin-filament function in relaxed and active muscle. The Journal of General Physiology. 155 |
Halder SS, Rynkiewicz MJ, Creso JG, et al. (2023) Mechanisms of pathogenicity in the hypertrophic cardiomyopathy-associated TPM1 variant S215L. Pnas Nexus. 2: pgad011 |