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William J Lehman

Affiliations: 
Boston University, Boston, MA, United States 
Area:
General Biophysics
Website:
https://www.bumc.bu.edu/busm/profile/william-lehman/
Google:
"William Jeffrey Lehman" OR "William J Lehman"
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Parents

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Lionel Israel Rebhun grad student 1966-1969 Princeton (Neurotree)
 (The structural elements responsible for contraction in the ciliate Spirostomum)
Andrew G. Szent-Györgyi post-doc 1969-1972 Brandeis (Cell Biology Tree)
Richard T. Tregear research scientist 1973-1973 Oxford (Physiology Academic Tree)
Kenneth C. Holmes research scientist 1975-1975 MPI for Medical Research (Computational Biology Tree)

Children

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Deanna Dennault grad student 1992-1993 Franklin Pierce University
Michael S. Rosol grad student 2001 Boston University
Anthony R. Cammarato grad student 2004 Boston University
Alnoor Pirani grad student 2008 Boston University
Jasmine Nirody grad student 2010-2011 UCSF (Neurotree)
Xiaochuan Li post-doc MassMutual Financial Group
Anita Ghosh post-doc 2018- Boston University (Cell & Gene Therapy Tree)
Elumalai Pavadai post-doc 2019- Boston University
Julie Hodgkinson post-doc 1995-1998 Hannover Medical School
Chen Xu post-doc 1995-1998 University Of Massachusetts Med Sch Worcester
D. Bryan Foster post-doc 2001-2003 Johns Hopkins
Kiran Pant post-doc 2004-2006 Northeastern University
Agnieszka Galinska-Rakoczy Collins post-doc 2006-2009 Massachusetts General Hospital & Harvard Medical School
Duncan Sousa post-doc 2007-2011 Johns Hopkins Medical School
Worawit Supamumgmee post-doc 2009-2013 Mahidol University
Marek Orzechowski post-doc 2010-2015 Broad Institute (MIT/Harvard)
Michael Rynkiewicz research scientist 2015- Boston University
Farooq Kiani research scientist 2017-2018 Boston University

Collaborators

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Publications

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Rynkiewicz MJ, Pavadai E, Lehman W. (2022) Modeling Human Cardiac Thin Filament Structures. Frontiers in Physiology. 13: 932333
Suphamungmee W, Lehman W, Morgan KG. (2022) Functional Remodeling of the Contractile Smooth Muscle Cell Cortex, a Provocative Concept, Supported by Direct Visualization of Cortical Remodeling. Biology. 11
Pavadai E, Rynkiewicz MJ, Yang Z, et al. (2022) Modulation of cardiac thin filament structure by phosphorylated troponin-I analyzed by protein-protein docking and molecular dynamics simulation. Archives of Biochemistry and Biophysics. 725: 109282
Teekakirikul P, Zhu W, Xu X, et al. (2022) Genetic resiliency associated with dominant lethal mutation causing atrial septal defect with high heritability. Cell Reports. Medicine. 3: 100501
Doran MH, Lehman W. (2021) The Central Role of the F-Actin Surface in Myosin Force Generation. Biology. 10
Sewanan LR, Park J, Rynkiewicz MJ, et al. (2021) Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation. The Journal of General Physiology. 153
Lehman W, Pavadai E, Rynkiewicz MJ. (2021) C-terminal troponin-I residues trap tropomyosin in the muscle thin filament blocked-state. Biochemical and Biophysical Research Communications. 551: 27-32
Racca AW, Rynkiewicz MJ, LaFave N, et al. (2020) M8R tropomyosin mutation disrupts actin-binding and filament regulation: the beginning affects the middle and end. The Journal of Biological Chemistry
Doran MH, Pavadai E, Rynkiewicz MJ, et al. (2020) Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments. Biophysical Journal
Pavadai E, Lehman W, Rynkiewicz MJ. (2020) Protein-Protein Docking Reveals Dynamic Interactions of Tropomyosin on Actin Filaments. Biophysical Journal. 119: 75-86
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