☰ Physics Tree

William J Lehman

Affiliations:

Boston University, Boston, MA, United States

Area:

General Biophysics

Website:

https://www.bumc.bu.edu/busm/profile/william-lehman/

Google:

"William Jeffrey Lehman" OR "William J Lehman"

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Parents

Lionel Israel Rebhun	grad student	1966-1969	Princeton (Neurotree)
(The structural elements responsible for contraction in the ciliate Spirostomum)
Andrew G. Szent-Györgyi	post-doc	1969-1972	Brandeis (Cell Biology Tree)
Richard T. Tregear	research scientist	1973-1973	Oxford (Physiology Academic Tree)
Kenneth C. Holmes	research scientist	1975-1975	MPI for Medical Research (Computational Biology Tree)

Children

Deanna Dennault	grad student	1992-1993	Franklin Pierce University
Michael S. Rosol	grad student	2001	Boston University
Anthony R. Cammarato	grad student	2004	Boston University
Alnoor Pirani	grad student	2008	Boston University
Jasmine Nirody	grad student	2010-2011	UCSF (Neurotree)
Xiaochuan Li	post-doc		MassMutual Financial Group
Anita Ghosh	post-doc	2018-	Boston University (Cell & Gene Therapy Tree)
Elumalai Pavadai	post-doc	2019-	Boston University
Julie Hodgkinson	post-doc	1995-1998	Hannover Medical School
Chen Xu	post-doc	1995-1998	University Of Massachusetts Med Sch Worcester
D. Bryan Foster	post-doc	2001-2003	Johns Hopkins
Kiran Pant	post-doc	2004-2006	Northeastern University
Agnieszka Galinska-Rakoczy Collins	post-doc	2006-2009	Massachusetts General Hospital & Harvard Medical School
Duncan Sousa	post-doc	2007-2011	Johns Hopkins Medical School
Worawit Supamumgmee	post-doc	2009-2013	Mahidol University
Marek Orzechowski	post-doc	2010-2015	Broad Institute (MIT/Harvard)
Michael Rynkiewicz	research scientist	2015-	Boston University
Farooq Kiani	research scientist	2017-2018	Boston University

Collaborators

BETA: Related publications

Publications

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Wen J, Campbell S, Moore J, et al. (2025) Screening single nucleotide changes to tropomyosin to identify novel cardiomyopathy mutants. Journal of Molecular and Cellular Cardiology. 203: 82-90
Ramachandran B, Rynkiewicz M, Lehman W. (2025) Velcro-binding by cardiac troponin-I traps tropomyosin on actin in a low-energy relaxed state. Biochemical and Biophysical Research Communications. 757: 151595
Barry ME, Rynkiewicz MJ, Wen J, et al. (2025) Dual Role of Tropomyosin-R160 in Thin Filament Regulation: Insights into Phosphorylation-Dependent Cardiac Relaxation and Cardiomyopathy Mechanisms. Archives of Biochemistry and Biophysics. 110380
Doran MH, Rynkiewicz MJ, Despond E, et al. (2025) The hypertrophic cardiomyopathy-associated A331P actin variant enhances basal contractile activity and elicits resting muscle dysfunction. Iscience. 28: 111816
Halder SS, Rynkiewicz MJ, Kim L, et al. (2024) Distinct mechanisms drive divergent phenotypes in hypertrophic and dilated cardiomyopathy associated TPM1 variants. The Journal of Clinical Investigation
Creso JG, Gokhan I, Rynkiewicz MJ, et al. (2024) In silico and in vitro models reveal the molecular mechanisms of hypocontractility caused by M8R. Frontiers in Physiology. 15: 1452509
Rynkiewicz MJ, Childers MC, Karpicheva OE, et al. (2024) Myosin's powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin. The Journal of General Physiology. 156
Barry ME, Rynkiewicz MJ, Pavadai E, et al. (2024) Glutamate 139 of tropomyosin is critical for cardiac thin filament blocked-state stabilization. Journal of Molecular and Cellular Cardiology
Lehman W, Rynkiewicz MJ. (2023) Troponin-I-induced tropomyosin pivoting defines thin-filament function in relaxed and active muscle. The Journal of General Physiology. 155
Halder SS, Rynkiewicz MJ, Creso JG, et al. (2023) Mechanisms of pathogenicity in the hypertrophic cardiomyopathy-associated TPM1 variant S215L. Pnas Nexus. 2: pgad011

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