William J Lehman

Affiliations: 
Boston University, Boston, MA, United States 
Area:
General Biophysics
Website:
https://www.bumc.bu.edu/busm/profile/william-lehman/
Google:
"William Jeffrey Lehman" OR "William J Lehman"
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Parents

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Lionel Israel Rebhun grad student 1966-1969 Princeton (Neurotree)
 (The structural elements responsible for contraction in the ciliate Spirostomum)
Andrew G. Szent-Györgyi post-doc 1969-1972 Brandeis (Cell Biology Tree)
Richard T. Tregear research scientist 1973-1973 Oxford (Physiology Academic Tree)
Kenneth C. Holmes research scientist 1975-1975 MPI for Medical Research (Computational Biology Tree)
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Publications

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Wen J, Campbell S, Moore J, et al. (2025) Screening single nucleotide changes to tropomyosin to identify novel cardiomyopathy mutants. Journal of Molecular and Cellular Cardiology. 203: 82-90
Ramachandran B, Rynkiewicz M, Lehman W. (2025) Velcro-binding by cardiac troponin-I traps tropomyosin on actin in a low-energy relaxed state. Biochemical and Biophysical Research Communications. 757: 151595
Barry ME, Rynkiewicz MJ, Wen J, et al. (2025) Dual Role of Tropomyosin-R160 in Thin Filament Regulation: Insights into Phosphorylation-Dependent Cardiac Relaxation and Cardiomyopathy Mechanisms. Archives of Biochemistry and Biophysics. 110380
Doran MH, Rynkiewicz MJ, Despond E, et al. (2025) The hypertrophic cardiomyopathy-associated A331P actin variant enhances basal contractile activity and elicits resting muscle dysfunction. Iscience. 28: 111816
Halder SS, Rynkiewicz MJ, Kim L, et al. (2024) Distinct mechanisms drive divergent phenotypes in hypertrophic and dilated cardiomyopathy associated TPM1 variants. The Journal of Clinical Investigation
Creso JG, Gokhan I, Rynkiewicz MJ, et al. (2024) In silico and in vitro models reveal the molecular mechanisms of hypocontractility caused by M8R. Frontiers in Physiology. 15: 1452509
Rynkiewicz MJ, Childers MC, Karpicheva OE, et al. (2024) Myosin's powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin. The Journal of General Physiology. 156
Barry ME, Rynkiewicz MJ, Pavadai E, et al. (2024) Glutamate 139 of tropomyosin is critical for cardiac thin filament blocked-state stabilization. Journal of Molecular and Cellular Cardiology
Lehman W, Rynkiewicz MJ. (2023) Troponin-I-induced tropomyosin pivoting defines thin-filament function in relaxed and active muscle. The Journal of General Physiology. 155
Halder SS, Rynkiewicz MJ, Creso JG, et al. (2023) Mechanisms of pathogenicity in the hypertrophic cardiomyopathy-associated TPM1 variant S215L. Pnas Nexus. 2: pgad011
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