William J Lehman

Affiliations: 
Boston University, Boston, MA, United States 
Area:
General Biophysics
Website:
https://www.bumc.bu.edu/busm/profile/william-lehman/
Google:
"William Jeffrey Lehman" OR "William J Lehman"
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Parents

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Lionel Israel Rebhun grad student 1966-1969 Princeton (Neurotree)
 (The structural elements responsible for contraction in the ciliate Spirostomum)
Andrew G. Szent-Györgyi post-doc 1969-1972 Brandeis (Cell Biology Tree)
Richard T. Tregear research scientist 1973-1973 Oxford (Physiology Academic Tree)
Kenneth C. Holmes research scientist 1975-1975 MPI (Computational Biology Tree)
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Publications

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Viswanathan MC, Schmidt W, Franz P, et al. (2020) A role for actin flexibility in thin filament-mediated contractile regulation and myopathy. Nature Communications. 11: 2417
Sundar S, Rynkiewicz MJ, Ghosh A, et al. (2019) Cardiomyopathy Mutation Alters End-to-End Junction of Tropomyosin and Reduces Calcium Sensitivity. Biophysical Journal
Pavadai E, Rynkiewicz MJ, Ghosh A, et al. (2019) Docking Troponin T onto the Tropomyosin Overlapping Domain of Thin Filaments. Biophysical Journal
Janco M, Rynkiewicz MJ, Li L, et al. (2019) Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1. Scientific Reports. 9: 11262
Lehman W, Moore JR, Campbell SG, et al. (2019) The Effect of Tropomyosin Mutations on Actin-Tropomyosin Binding: In Search of Lost Time. Biophysical Journal
Lehman W, Rynkiewicz MJ, Moore JR. (2019) A new twist on tropomyosin binding to actin filaments: perspectives on thin filament function, assembly and biomechanics. Journal of Muscle Research and Cell Motility
Kiani FA, Lehman W, Fischer S, et al. (2018) Spontaneous transitions of actin-bound tropomyosin toward blocked and closed states. The Journal of General Physiology
Lehman W, Li X, Kiani FA, et al. (2018) Precise Binding of Tropomyosin on Actin Involves Sequence-Dependent Variance in Coiled-Coil Twisting. Biophysical Journal
Farman GP, Rynkiewicz MJ, Orzechowski M, et al. (2018) HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments. Archives of Biochemistry and Biophysics
Rynkiewicz MJ, Prum T, Hollenberg S, et al. (2017) Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function. Biophysical Journal. 113: 2444-2451
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