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William J Lehman

Affiliations: 
Boston University, Boston, MA, United States 
Area:
General Biophysics
Website:
https://www.bumc.bu.edu/busm/profile/william-lehman/
Google:
"William Jeffrey Lehman" OR "William J Lehman"
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Parents

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Lionel Israel Rebhun grad student 1966-1969 Princeton (Neurotree)
 (The structural elements responsible for contraction in the ciliate Spirostomum)
Andrew G. Szent-Györgyi post-doc 1969-1972 Brandeis (Cell Biology Tree)
Richard T. Tregear research scientist 1973-1973 Oxford (Physiology Academic Tree)
Kenneth C. Holmes research scientist 1975-1975 MPI (Computational Biology Tree)

Children

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Deanna Dennault grad student 1992-1993 Franklin Pierce University
Michael S. Rosol grad student 2001 Boston University
Anthony R. Cammarato grad student 2004 Boston University
Alnoor Pirani grad student 2008 Boston University
Jasmine Nirody grad student 2010-2011 UCSF (Neurotree)
Xiaochuan Li post-doc MassMutual Financial Group
Anita Ghosh post-doc 2018- Boston University (Cell & Gene Therapy Tree)
Elumalai Pavadai post-doc 2019- Boston University
Julie Hodgkinson post-doc 1995-1998 Hannover Medical School
Chen Xu post-doc 1995-1998 University Of Massachusetts Med Sch Worcester
D. Bryan Foster post-doc 2001-2003 Johns Hopkins
Kiran Pant post-doc 2004-2006 Northeastern University
Agnieszka Galinska-Rakoczy Collins post-doc 2006-2009 Massachusetts General Hospital & Harvard Medical School
Duncan Sousa post-doc 2007-2011 Johns Hopkins Medical School
Worawit Supamumgmee post-doc 2009-2013 Mahidol University
Marek Orzechowski post-doc 2010-2015 Broad Institute (MIT/Harvard)
Michael Rynkiewicz research scientist 2015- Boston University
Farooq Kiani research scientist 2017-2018 Boston University

Collaborators

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Publications

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Viswanathan MC, Schmidt W, Franz P, et al. (2020) A role for actin flexibility in thin filament-mediated contractile regulation and myopathy. Nature Communications. 11: 2417
Sundar S, Rynkiewicz MJ, Ghosh A, et al. (2019) Cardiomyopathy Mutation Alters End-to-End Junction of Tropomyosin and Reduces Calcium Sensitivity. Biophysical Journal
Pavadai E, Rynkiewicz MJ, Ghosh A, et al. (2019) Docking Troponin T onto the Tropomyosin Overlapping Domain of Thin Filaments. Biophysical Journal
Janco M, Rynkiewicz MJ, Li L, et al. (2019) Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1. Scientific Reports. 9: 11262
Lehman W, Moore JR, Campbell SG, et al. (2019) The Effect of Tropomyosin Mutations on Actin-Tropomyosin Binding: In Search of Lost Time. Biophysical Journal
Lehman W, Rynkiewicz MJ, Moore JR. (2019) A new twist on tropomyosin binding to actin filaments: perspectives on thin filament function, assembly and biomechanics. Journal of Muscle Research and Cell Motility
Kiani FA, Lehman W, Fischer S, et al. (2018) Spontaneous transitions of actin-bound tropomyosin toward blocked and closed states. The Journal of General Physiology
Lehman W, Li X, Kiani FA, et al. (2018) Precise Binding of Tropomyosin on Actin Involves Sequence-Dependent Variance in Coiled-Coil Twisting. Biophysical Journal
Farman GP, Rynkiewicz MJ, Orzechowski M, et al. (2018) HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments. Archives of Biochemistry and Biophysics
Rynkiewicz MJ, Prum T, Hollenberg S, et al. (2017) Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function. Biophysical Journal. 113: 2444-2451
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