Joe Bentz

Affiliations: 
Drexel University, Philadelphia, PA, United States 
Area:
General Biophysics, Biochemistry, Molecular Biology
Website:
http://drexel.edu/coas/faculty-research/faculty-directory/bentz-joseph/
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"Joe Bentz"
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Parents

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Shlomo Nir grad student 1979 SUNY Buffalo (Chemistry Tree)
 (On the analysis of aggregation of acidic phospholipid vesicles with regard to cation environment, temperature and their free energy of interaction.)

Children

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Aditya Mittal grad student 2002 Drexel
Poulomi Acharya grad student 2007 Drexel
Annie A. Lumen grad student 2011 Drexel
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Publications

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Bentz J, Ellens H. (2021) Case Study 8: Status of the Structural Mass Action Kinetic Model of P-gp-Mediated Transport Through Confluent Cell Monolayers. Methods in Molecular Biology (Clifton, N.J.). 2342: 737-763
Ellens H, Meng Z, Le Marchand SJ, et al. (2018) Mechanistic kinetic modeling generates system-independent P-glycoprotein mediated transport elementary rate constants for inhibition and, in combination with 3D SIM microscopy, elucidates the importance of microvilli morphology on P-glycoprotein mediated efflux activity. Expert Opinion On Drug Metabolism & Toxicology
Chaudhry A, Chung G, Lynn A, et al. (2018) Derivation of a system-independent Ki for Pgp-mediated digoxin transport from system-dependent IC50 data by accounting for the contribution of additional digoxin transporters. Drug Metabolism and Disposition: the Biological Fate of Chemicals
Meng Z, Ellens H, Bentz J. (2016) Extrapolation of elementary rate constants of P-glycoprotein mediated transport from MDCKII-hMDR1 to Caco-2 cells. Drug Metabolism and Disposition: the Biological Fate of Chemicals
Meng Z, Le Marchand S, Agnani D, et al. (2016) Microvilli morphology can affect efflux active P-glycoprotein in confluent MDCKII-NKI_hMDR1 and Caco-2 cell monolayers. Drug Metabolism and Disposition: the Biological Fate of Chemicals
O'Connor M, Lee C, Ellens H, et al. (2015) A novel application of t-statistics to objectively assess the quality of IC50 fits for P-glycoprotein and other transporters. Pharmacology Research & Perspectives. 3: e00078
Bentz J, Ellens H. (2014) A structural model for the mass action kinetic analysis of P-gp mediated transport through confluent cell monolayers. Methods in Molecular Biology (Clifton, N.J.). 1113: 289-316
Lumen AA, Li L, Li J, et al. (2013) Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp. Plos One. 8: e69394
Ellens H, Deng S, Coleman J, et al. (2013) Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactions. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1367-74
Bentz J, O'Connor MP, Bednarczyk D, et al. (2013) Variability in P-glycoprotein inhibitory potency (IC₅₀) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk assessment decision criteria. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1347-66
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