Poulomi Acharya, Ph.D.
Affiliations: | 2007 | Drexel University, Philadelphia, PA, United States |
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General Biology, Cell Biology, Molecular BiologyGoogle:
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Wang Y, Guan S, Acharya P, et al. (2012) Multisite phosphorylation of human liver cytochrome P450 3A4 enhances Its gp78- and CHIP-mediated ubiquitination: a pivotal role of its Ser-478 residue in the gp78-catalyzed reaction. Molecular & Cellular Proteomics : McP. 11: M111.010132 |
Agnani D, Acharya P, Martinez E, et al. (2011) Fitting the elementary rate constants of the P-gp transporter network in the hMDR1-MDCK confluent cell monolayer using a particle swarm algorithm. Plos One. 6: e25086 |
Wang Y, Guan S, Acharya P, et al. (2011) Ubiquitin-dependent proteasomal degradation of human liver cytochrome P450 2E1: identification of sites targeted for phosphorylation and ubiquitination. The Journal of Biological Chemistry. 286: 9443-56 |
Acharya P, Liao M, Engel JC, et al. (2011) Liver cytochrome P450 3A endoplasmic reticulum-associated degradation: a major role for the p97 AAA ATPase in cytochrome P450 3A extraction into the cytosol. The Journal of Biological Chemistry. 286: 3815-28 |
Kim SM, Acharya P, Engel JC, et al. (2010) Liver cytochrome P450 3A ubiquitination in vivo by gp78/autocrine motility factor receptor and C terminus of Hsp70-interacting protein (CHIP) E3 ubiquitin ligases: physiological and pharmacological relevance. The Journal of Biological Chemistry. 285: 35866-77 |
Lumen AA, Acharya P, Polli JW, et al. (2010) If the KI is defined by the free energy of binding to P-glycoprotein, which kinetic parameters define the IC50 for the Madin-Darby canine kidney II cell line overexpressing human multidrug resistance 1 confluent cell monolayer? Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 260-9 |
Wang Y, Liao M, Hoe N, et al. (2009) A role for protein phosphorylation in cytochrome P450 3A4 ubiquitin-dependent proteasomal degradation. The Journal of Biological Chemistry. 284: 5671-84 |
Acharya P, O'Connor MP, Polli JW, et al. (2008) Kinetic identification of membrane transporters that assist P-glycoprotein-mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII-hMDR1 cells. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 452-60 |
Acharya P, Tran TT, Polli JW, et al. (2006) P-Glycoprotein (P-gp) expressed in a confluent monolayer of hMDR1-MDCKII cells has more than one efflux pathway with cooperative binding sites. Biochemistry. 45: 15505-19 |