Poulomi Acharya, Ph.D.

Affiliations: 
2007 Drexel University, Philadelphia, PA, United States 
Area:
General Biology, Cell Biology, Molecular Biology
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"Poulomi Acharya"
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Joe Bentz grad student 2007 Drexel
 (Modeling the Transport and Inhibition Kinetics of the Human Multidrug Resistance Transporter P-Glycoprotein in MDCK-II Cells.)
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Wang Y, Guan S, Acharya P, et al. (2012) Multisite phosphorylation of human liver cytochrome P450 3A4 enhances Its gp78- and CHIP-mediated ubiquitination: a pivotal role of its Ser-478 residue in the gp78-catalyzed reaction. Molecular & Cellular Proteomics : McP. 11: M111.010132
Agnani D, Acharya P, Martinez E, et al. (2011) Fitting the elementary rate constants of the P-gp transporter network in the hMDR1-MDCK confluent cell monolayer using a particle swarm algorithm. Plos One. 6: e25086
Lumen AA, Acharya P, Polli JW, et al. (2010) If the KI is defined by the free energy of binding to P-glycoprotein, which kinetic parameters define the IC50 for the Madin-Darby canine kidney II cell line overexpressing human multidrug resistance 1 confluent cell monolayer? Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 260-9
Wang Y, Liao M, Hoe N, et al. (2009) A role for protein phosphorylation in cytochrome P450 3A4 ubiquitin-dependent proteasomal degradation. The Journal of Biological Chemistry. 284: 5671-84
Acharya P, O'Connor MP, Polli JW, et al. (2008) Kinetic identification of membrane transporters that assist P-glycoprotein-mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII-hMDR1 cells. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 452-60
Acharya P, Tran TT, Polli JW, et al. (2006) P-Glycoprotein (P-gp) expressed in a confluent monolayer of hMDR1-MDCKII cells has more than one efflux pathway with cooperative binding sites. Biochemistry. 45: 15505-19
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