Nicholas R. Silvaggi, Ph.D.

Affiliations: 
2003 University of Connecticut, Storrs, CT, United States 
Area:
General Biophysics, Biochemistry, Pharmacology
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"Nicholas Silvaggi"
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Parents

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Judith A. Kelly grad student 2003 University of Connecticut
 (On the road toward better antibiotics: Crystallographic studies of a penicillin -binding protein.)
Karen N. Allen post-doc Boston University (Chemistry Tree)
 (crystallography)

Children

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Nemanja Vuksanovic grad student (Chemistry Tree)
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Publications

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Vuksanovic N, Melkonian TR, Serrano DA, et al. (2023) Structural and Biochemical Characterization of MppQ, an L-Enduracididine Biosynthetic Enzyme from . Biochemistry. 62: 3105-3115
Melkonian TR, Vuksanovic N, Silvaggi NR. (2023) Probing mechanistic questions in the PLP- and O-dependent l-Arg oxidases. Methods in Enzymology. 685: 493-529
Johnston N, Samuels TL, Goetz CJ, et al. (2022) Oral and Inhaled Fosamprenavir Reverses Pepsin-Induced Damaged in a Laryngopharyngeal Reflux Mouse Model. The Laryngoscope
Turner LD, Nielsen AL, Lin L, et al. (2021) Use of Crystallography and Molecular Modeling for the Inhibition of the Botulinum Neurotoxin A Protease. Acs Medicinal Chemistry Letters. 12: 1318-1324
Virdi RS, Bavisotto RV, Hopper NC, et al. (2020) Discovery of Drug-Like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3. Slas Discovery : Advancing Life Sciences R & D. 2472555220960428
Vuksanovic N, Zhu X, Serrano DA, et al. (2020) Structural characterization of three noncanonical NTF2-like superfamily proteins: implications for polyketide biosynthesis. Acta Crystallographica. Section F, Structural Biology Communications. 76: 372-383
Frick DN, Virdi RS, Vuksanovic N, et al. (2020) Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3. Biochemistry
Han L, Vuksanovic N, Oehm SA, et al. (2019) Correction to " MppP is a PLP-Dependent Oxidase, Not an Oxygenase". Biochemistry
Mydy L, Hoppe RW, Hagemann TM, et al. (2019) Mechanistic Studies of the Streptomyces bingchenggensis Aldolase-Dehydratase: Implications for Substrate and Reaction Specificity in the Acetoacetate Decarboxylase-Like Superfamily. Biochemistry
Roman JV, Melkonian TR, Silvaggi N, et al. (2019) Transient State Analysis of Human Isocitrate Dehydrogenase I: Accounting for the Interconversion of Active and Non-Active Conformational States. Biochemistry
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