Nicholas R. Silvaggi, Ph.D.

Affiliations: 
2003 University of Connecticut, Storrs, CT, United States 
Area:
General Biophysics, Biochemistry, Pharmacology
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"Nicholas Silvaggi"
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Parents

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Judith A. Kelly grad student 2003 University of Connecticut
 (On the road toward better antibiotics: Crystallographic studies of a penicillin -binding protein.)
Karen N. Allen post-doc Boston University (Chemistry Tree)
 (crystallography)
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Publications

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Mydy L, Hoppe RW, Hagemann TM, et al. (2019) Mechanistic Studies of the Streptomyces bingchenggensis Aldolase-Dehydratase: Implications for Substrate and Reaction Specificity in the Acetoacetate Decarboxylase-Like Superfamily. Biochemistry
Han L, Vuksanovic N, Oehm SA, et al. (2018) Streptomyces wadayamensis MppP is a PLP-dependent oxidase, not an oxygenase. Biochemistry
Mydy LS, Mashhadi Z, Knight TW, et al. (2017) Swit_4259, an acetoacetate decarboxylase-like enzyme from Sphingomonas wittichii RW1. Acta Crystallographica. Section F, Structural Biology Communications. 73: 672-681
Jacobson AR, Adler M, Silvaggi NR, et al. (2017) Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A. Toxicon : Official Journal of the International Society On Toxinology
Han L, Schwabacher AW, Moran GR, et al. (2015) Streptomyces wadayamensis MppP is a PLP-Dependent L-Arginine α-deaminase, γ-Hydroxylase in the Enduracididine Biosynthetic Pathway. Biochemistry
Guthrie ML, Sidhu PS, Hill EK, et al. (2015) Antitumor Activity of 3-Indolylmethanamines 31B and PS121912. Anticancer Research. 35: 6001-7
Mueller LS, Hoppe RW, Ochsenwald JM, et al. (2015) Sbi00515, a Protein of Unknown Function from Streptomyces bingchenggensis, Highlights the Functional Versatility of the Acetoacetate Decarboxylase Scaffold. Biochemistry. 54: 3978-88
Hoag MR, Roman J, Beaupre BA, et al. (2015) Bacterial Renalase: Structure and Kinetics of an Enzyme with 2- and 6-Dihydro-β-NAD(P) Oxidase Activity from Pseudomonas phaseolicola. Biochemistry. 54: 3791-802
Maule AF, Wright DP, Weiner JJ, et al. (2015) The aspartate-less receiver (ALR) domains: distribution, structure and function. Plos Pathogens. 11: e1004795
Sidhu PS, Teske K, Feleke B, et al. (2014) Anticancer activity of VDR-coregulator inhibitor PS121912. Cancer Chemotherapy and Pharmacology. 74: 787-98
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