Pen-Jen Lin, Ph.D.

Affiliations: 
2003 University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Medical Biophysics, Molecular Biology
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"Pen-Jen Lin"
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Darrel W. Stafford grad student 2003 UNC Chapel Hill
 (Characterization of the putative vitamin K-dependent carboxylase internal propeptide sequence.)
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Publications

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Higgins-Gruber SL, Mutucumarana VP, Lin PJ, et al. (2010) Effect of vitamin K-dependent protein precursor propeptide, vitamin K hydroquinone, and glutamate substrate binding on the structure and function of {gamma}-glutamyl carboxylase. The Journal of Biological Chemistry. 285: 31502-8
Soute BA, Jin DY, Spronk HM, et al. (2004) Characteristics of recombinant W501S mutated human gamma-glutamyl carboxylase. Journal of Thrombosis and Haemostasis : Jth. 2: 597-604
Li T, Chang CY, Jin DY, et al. (2004) Identification of the gene for vitamin K epoxide reductase. Nature. 427: 541-4
Lin PJ, Straight DL, Stafford DW. (2004) Binding of the factor IX gamma-carboxyglutamic acid domain to the vitamin K-dependent gamma-glutamyl carboxylase active site induces an allosteric effect that may ensure processive carboxylation and regulate the release of carboxylated product. The Journal of Biological Chemistry. 279: 6560-6
Wang CP, Yagi K, Lin PJ, et al. (2003) Identification of a gene encoding a typical gamma-carboxyglutamic acid domain in the tunicate Halocynthia roretzi. Journal of Thrombosis and Haemostasis : Jth. 1: 118-23
Lin PJ, Jin DY, Tie JK, et al. (2002) The putative vitamin K-dependent gamma-glutamyl carboxylase internal propeptide appears to be the propeptide binding site. The Journal of Biological Chemistry. 277: 28584-91
Stanley TB, Jin DY, Lin PJ, et al. (1999) The propeptides of the vitamin K-dependent proteins possess different affinities for the vitamin K-dependent carboxylase. The Journal of Biological Chemistry. 274: 16940-4
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