Lauren J. Murphree, Ph.D.

Affiliations: 
2004 University of Virginia, Charlottesville, VA 
Area:
Pharmacology
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"Lauren Murphree"
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Parents

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Joel Linden grad student 2004 UVA
 (A(2A) adenosine receptor signaling pathways as endogenous regulators of inflammation.)
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Publications

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McIntire WE, MacCleery G, Murphree LJ, et al. (2006) Influence of differential stability of G protein βγ dimers containing the γ11 subunit on functional activity at the M1 muscarinic receptor, A1 adenosine receptor, and phospholipase C-β. Biochemistry. 45: 11616-31
Chordia MD, Zigler M, Murphree LJ, et al. (2005) 6-Aryl-8H-indeno[1,2-d]thiazol-2-ylamines: A1 adenosine receptor agonist allosteric enhancers having improved potency Journal of Medicinal Chemistry. 48: 5131-5139
Murphree LJ, Sullivan GW, Marshall MA, et al. (2005) Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: role of NF-kappaB in A(2A) adenosine receptor induction. The Biochemical Journal. 391: 575-80
Chordia MD, Murphree LJ, Macdonald TL, et al. (2002) 2-Aminothiazoles: A new class of agonist allosteric enhancers of A1 adenosine receptors Bioorganic and Medicinal Chemistry Letters. 12: 1563-1566
Murphree LJ, Marshall MA, Rieger JM, et al. (2002) Human A2A adenosine receptors: High-affinity agonist binding to receptor-g protein complexes containing Gβ4 Molecular Pharmacology. 61: 455-462
Tranberg CE, Zickgraf A, Giunta BN, et al. (2002) 2-Amino-3-aroyl-4,5-alkylthiophenes: agonist allosteric enhancers at human A(1) adenosine receptors. Journal of Medicinal Chemistry. 45: 382-9
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