Utpal B. Pajvani, Ph.D.

Affiliations: 
2005 Yeshiva University, New York, NY, United States 
Area:
Cell Biology, Animal Physiology Biology, Molecular Biology
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"Utpal Pajvani"
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Philipp E. Scherer grad student 2005 Yeshiva University
 (Functional consequences of adiponectin oligomerization state: The role of adiponectin in maintaining systemic insulin sensitivity.)
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Publications

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Sparling DP, Yu J, Kim K, et al. (2016) Adipocyte-specific blockade of gamma-secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity. Molecular Metabolism. 5: 113-21
Kim K, Qiang L, Hayden MS, et al. (2016) mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2. Nature Communications. 7: 10255
Valenti L, Mendoza RM, Rametta R, et al. (2013) Hepatic notch signaling correlates with insulin resistance and nonalcoholic fatty liver disease. Diabetes. 62: 4052-62
Pajvani UB, Qiang L, Kangsamaksin T, et al. (2013) Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability. Nature Medicine. 19: 1054-60
Pajvani UB, Shawber CJ, Samuel VT, et al. (2011) Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner. Nature Medicine. 17: 961-7
Basu R, Pajvani UB, Rizza RA, et al. (2007) Selective downregulation of the high molecular weight form of adiponectin in hyperinsulinemia and in type 2 diabetes: differential regulation from nondiabetic subjects. Diabetes. 56: 2174-7
Nawrocki AR, Rajala MW, Tomas E, et al. (2006) Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. The Journal of Biological Chemistry. 281: 2654-60
Trujillo ME, Pajvani UB, Scherer PE. (2005) Apoptosis through targeted activation of caspase 8 ("ATTAC-mice"): novel mouse models of inducible and reversible tissue ablation. Cell Cycle (Georgetown, Tex.). 4: 1141-5
Pajvani UB, Trujillo ME, Combs TP, et al. (2005) Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy. Nature Medicine. 11: 797-803
Bouskila M, Pajvani UB, Scherer PE. (2005) Adiponectin: a relevant player in PPARgamma-agonist-mediated improvements in hepatic insulin sensitivity? International Journal of Obesity (2005). 29: S17-23
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