Shannon E. Telesco, Ph.D.

Affiliations: 
2011 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Biomedical Engineering, Oncology, Molecular Biology
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"Shannon Telesco"
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Parents

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Ravi Radhakrishnan grad student 2011 Penn
 (Multiscale modeling of the ErbB receptor tyrosine kinase signaling network through theory and experiment.)
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Publications

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Telesco SE, Vadigepalli R, Radhakrishnan R. (2013) Molecular modeling of ErbB4/HER4 kinase in the context of the HER4 signaling network helps rationalize the effects of clinically identified HER4 somatic mutations on the cell phenotype. Biotechnology Journal. 8: 1452-64
Telesco SE, Radhakrishnan R. (2012) Structural systems biology and multiscale signaling models. Annals of Biomedical Engineering. 40: 2295-306
Telesco SE, Shih A, Liu Y, et al. (2011) Investigating Molecular Mechanisms of Activation and Mutation of the HER2 Receptor Tyrosine Kinase through Computational Modeling and Simulation. Cancer Research Journal. 4: 1-35
Shih AJ, Telesco SE, Radhakrishnan R. (2011) Analysis of Somatic Mutations in Cancer: Molecular Mechanisms of Activation in the ErbB Family of Receptor Tyrosine Kinases. Cancers. 3: 1195-231
Telesco SE, Shih AJ, Jia F, et al. (2011) A multiscale modeling approach to investigate molecular mechanisms of pseudokinase activation and drug resistance in the HER3/ErbB3 receptor tyrosine kinase signaling network. Molecular Biosystems. 7: 2066-80
Shih AJ, Telesco SE, Choi SH, et al. (2011) Molecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinases. The Biochemical Journal. 436: 241-51
Shi F, Telesco SE, Liu Y, et al. (2010) ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 107: 7692-7
Telesco SE, Radhakrishnan R. (2009) Atomistic insights into regulatory mechanisms of the HER2 tyrosine kinase domain: a molecular dynamics study. Biophysical Journal. 96: 2321-34
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