Justin F. Shaffer, Ph.D.

Affiliations: 
2010 University of Washington, Seattle, Seattle, WA 
Area:
General Biophysics, Biochemistry, Biomedical Engineering
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Samantha Harris grad student 2010 University of Washington
 (Interactions between cardiac myosin binding protein-C and actin contribute to the regulation of muscle contraction.)
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Publications

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Chow ML, Shaffer JF, Harris SP, et al. (2014) Altered interactions between cardiac myosin binding protein-C and α-cardiac actin variants associated with cardiomyopathies. Archives of Biochemistry and Biophysics. 550: 28-32
Bezold KL, Shaffer JF, Khosa JK, et al. (2013) A gain-of-function mutation in the M-domain of cardiac myosin-binding protein-C increases binding to actin Journal of Biological Chemistry. 288: 21496-21505
Shaffer JF, Kier WM. (2012) Muscular tissues of the squid Doryteuthis pealeii express identical myosin heavy chain isoforms: an alternative mechanism for tuning contractile speed. The Journal of Experimental Biology. 215: 239-46
Kensler RW, Shaffer JF, Harris SP. (2011) Binding of the N-terminal fragment C0-C2 of cardiac MyBP-C to cardiac F-actin. Journal of Structural Biology. 174: 44-51
Shaffer JF, Gillis TE. (2010) Evolution of the regulatory control of vertebrate striated muscle: the roles of troponin I and myosin binding protein-C. Physiological Genomics. 42: 406-19
Shaffer JF, Wong P, Bezold KL, et al. (2010) Functional differences between the N-terminal domains of mouse and human myosin binding protein-C. Journal of Biomedicine & Biotechnology. 2010: 789798
Jia W, Shaffer JF, Harris SP, et al. (2010) Identification of novel protein kinase A phosphorylation sites in the M-domain of human and murine cardiac myosin binding protein-C using mass spectrometry analysis. Journal of Proteome Research. 9: 1843-53
Shaffer JF, Harris SP. (2010) Identification of Amino Acid Residues in the Cardiac Myosin Binding Protein-C Motif Important for Actin Binding Biophysical Journal. 98: 756a
Shaffer JF, Wong P, Bezold KL, et al. (2010) Comparative Effects of the Proline-Alanine Rich Regions of Human and Murine Cardiac Myosin Binding Protein-C Biophysical Journal. 98: 555a
Bezold KL, Hoye E, Shaffer J, et al. (2010) Incorporation of the A31P Cardiac Myosin Binding Protein C Missense Mutation Into Feline Cardiac Sarcomeres Biophysical Journal. 98: 554a
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