Joachim Jaeger

Biomedical Sciences State University of New York, Albany, Albany, NY, United States 
Biochemistry, General Biophysics
"Joachim Jaeger"
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Cherry AL, Dennis CA, Baron A, et al. (2015) Hydrophobic and charged residues in the C-terminal arm of hepatitis C virus RNA-dependent RNA polymerase regulate initiation and elongation. Journal of Virology. 89: 2052-63
Gridley CL, Rangarajan S, Firbank S, et al. (2013) Structural changes in the hydrophobic hinge region adversely affect the activity and fidelity of the I260Q mutator DNA polymerase β. Biochemistry. 52: 4422-32
Jaeger J, Belfort M. (2013) Hand-holding for retrohoming in a molecular diversity dance. Structure (London, England : 1993). 21: 195-6
Curti E, Jaeger J. (2013) Residues Arg283, Arg285, and Ile287 in the nucleotide binding pocket of bovine viral diarrhea virus NS5B RNA polymerase affect catalysis and fidelity. Journal of Virology. 87: 199-207
Li Y, Gridley CL, Jaeger J, et al. (2012) Unfavorable electrostatic and steric interactions in DNA polymerase β E295K mutant interfere with the enzyme's pathway. Journal of the American Chemical Society. 134: 9999-10010
Murphy DL, Donigan KA, Jaeger J, et al. (2012) The E288K colon tumor variant of DNA polymerase β is a sequence specific mutator. Biochemistry. 51: 5269-75
Van Slyke GA, Ciota AT, Willsey GG, et al. (2012) Point mutations in the West Nile virus (Flaviviridae; Flavivirus) RNA-dependent RNA polymerase alter viral fitness in a host-dependent manner in vitro and in vivo. Virology. 427: 18-24
Murphy DL, Jaeger J, Sweasy JB. (2011) A triad interaction in the fingers subdomain of DNA polymerase beta controls polymerase activity. Journal of the American Chemical Society. 133: 6279-87
Yamtich J, Starcevic D, Lauper J, et al. (2010) Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta. Biochemistry. 49: 2326-34
Lin GC, Jaeger J, Eckert KA, et al. (2009) Loop II of DNA polymerase beta is important for discrimination during substrate binding. Dna Repair. 8: 182-9
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