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Yijun Huang, Ph.D.

Affiliations: 
2011 University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Pharmacy, General Biophysics
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"Yijun Huang"
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Alexander Doemling grad student 2011 University of Pittsburgh
 (Discovery of small molecule inhibitors of protein-protein interactions.)

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Christner SM, Clausen DM, Beumer JH, et al. (2015) In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of pyrazole-based small molecule inhibitors of Mdm2/4-p53 interaction. Cancer Chemotherapy and Pharmacology
Boltjes A, Huang Y, van de Velde R, et al. (2014) Fragment-based library generation for the discovery of a peptidomimetic p53-Mdm4 inhibitor. Acs Combinatorial Science. 16: 393-6
Huang Y, Wolf S, Beck B, et al. (2014) Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities. Acs Chemical Biology. 9: 802-11
Bista M, Wolf S, Khoury K, et al. (2013) Transient protein states in designing inhibitors of the MDM2-p53 interaction. Structure (London, England : 1993). 21: 2143-51
Huang Y, Khoury K, Chanas T, et al. (2012) Multicomponent synthesis of diverse 1,4-benzodiazepine scaffolds. Organic Letters. 14: 5916-9
Koes D, Khoury K, Huang Y, et al. (2012) Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists. Plos One. 7: e32839
Huang Y, Wolf S, Koes D, et al. (2012) Exhaustive fluorine scanning toward potent p53-Mdm2 antagonists. Chemmedchem. 7: 49-52
Huang Y, Dömling A. (2011) The Gewald multicomponent reaction. Molecular Diversity. 15: 3-33
Czarna A, Beck B, Srivastava S, et al. (2010) Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists. Angewandte Chemie (International Ed. in English). 49: 5352-6
Huang Y, Dömling A. (2010) 1,4-Thienodiazepine-2,5-diones via MCR (II): scaffold hopping by Gewald and Ugi-deprotection-cyclization strategy. Chemical Biology & Drug Design. 76: 130-41
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