James A. Spudich
Affiliations: | Stanford University, Palo Alto, CA |
Area:
myosinWebsite:
http://spudlab.stanford.edu/Google:
"James Spudich"Bio:
http://chemistry.library.nd.edu/resources/genealogy/chemistry/documents/SpudichJA.pdf
Cross-listing: Chemistry Tree
Parents
Sign in to add mentorArthur Kornberg | grad student | 1968 | Stanford | |
(The nature and origin of bacterial spore proteins) |
Children
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Publications
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Nandwani N, Bhowmik D, Childers MC, et al. (2024) Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human beta-cardiac myosin allosterically. Biorxiv : the Preprint Server For Biology |
Morck MM, Bhowmik D, Pathak D, et al. (2022) Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function. Elife. 11 |
Sarkar SS, Trivedi DV, Morck MM, et al. (2020) The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin. Science Advances. 6: eaax0069 |
Trivedi DV, Nag S, Spudich A, et al. (2020) The Myosin Family of Mechanoenzymes: From Mechanisms to Therapeutic Approaches. Annual Review of Biochemistry |
Bhowmik D, Nandwani N, Ruppel K, et al. (2020) Study of Hcm Causing β-Cardiac Myosin Mutations Located at Different Structurally Significant Regions of the Myosin-Head Biophysical Journal. 118: 435a |
Nandwani N, Trivedi DV, Sarkar SS, et al. (2020) Uncovering the Molecular and Structural Basis of Hypertrophic Cardiomyopathy-Causing Mutations in Myosin and Myosin Binding Protein-C Biophysical Journal. 118: 435a |
Vera CD, Johnson CA, Walklate J, et al. (2019) Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties. The Journal of Biological Chemistry |
Adhikari AS, Trivedi DV, Sarkar SS, et al. (2019) β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity. Nature Communications. 10: 2685 |
Spudich JA. (2019) Three perspectives on the molecular basis of hypercontractility caused by hypertrophic cardiomyopathy mutations. Pflugers Archiv : European Journal of Physiology |
Trivedi DV, Sarkar SS, Adhikari AS, et al. (2019) On the Functional Assessment of Hypertrophic Cardiomyopathy-Causing Mutations in Human β-Cardiac Myosin and the Role of Myosin Binding Protein-C Biophysical Journal. 116: 466a-467a |