Marek Orzechowski
Affiliations: | 2010-2015 | Broad Institute (MIT/Harvard) |
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| Farman GP, Rynkiewicz MJ, Orzechowski M, et al. (2018) HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments. Archives of Biochemistry and Biophysics |
| Viswanathan MC, Schmidt W, Orzechowski M, et al. (2017) The Actc A295S Hypertrophic Cardiomyopathy Mutation Promotes Thin Filament Disinhibition and Enhances Contractile Activity Biophysical Journal. 112 |
| Farman GP, Rynkiewicz M, Orzechowski M, et al. (2016) Cardiomyopathy Linked Mutations in Alpha Tropomyosin Influence Blocked State Stability but not Myosin Strong Binding Biophysical Journal. 110: 124a-125a |
| Rynkiewicz M, Schott V, Orzechowski M, et al. (2016) Does Tropomyosin Slide or Roll over F-Actin during Regulatory Transitions? Biophysical Journal. 110 |
| Rynkiewicz MJ, Schott V, Orzechowski M, et al. (2015) Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin. Journal of Muscle Research and Cell Motility. 36: 525-33 |
| Farman GP, Orzechowski M, Fischer S, et al. (2015) Serine 61 Phosphorylation Rescues Cardiomyopathic Effects of Tropomyosin Mutation Biophysical Journal. 108: 446a-447a |
| Orzechowski M, Fischer S, Moore JR, et al. (2014) Energy landscapes reveal the myopathic effects of tropomyosin mutations. Archives of Biochemistry and Biophysics. 564: 89-99 |
| Orzechowski M, Li XE, Fischer S, et al. (2014) An atomic model of the tropomyosin cable on F-actin. Biophysical Journal. 107: 694-9 |
| Li XE, Orzechowski M, Lehman W, et al. (2014) Structure and flexibility of the tropomyosin overlap junction. Biochemical and Biophysical Research Communications. 446: 304-8 |
| Yang S, Barbu-Tudoran L, Orzechowski M, et al. (2014) Three-dimensional organization of troponin on cardiac muscle thin filaments in the relaxed state. Biophysical Journal. 106: 855-64 |