Jean-Pierre Jaffrezou - Publications

Affiliations: 
1992- Stanford University School of Medicine, Palo Alto, CA, United States 

46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Chen KG, Duran GE, Mogul MJ, Wang YC, Ross KL, Jaffrézou JP, Huff LM, Johnson KR, Fojo T, Lacayo NJ, Sikic BI. Genomic stability at the coding regions of the multidrug transporter gene : insights into the development of alternative drug resistance mechanisms in human leukemia cells. Cancer Drug Resistance (Alhambra, Calif.). 3: 959-979. PMID 34541464 DOI: 10.20517/cdr.2020.51  0.605
2006 Ségui B, Andrieu-Abadie N, Jaffrézou JP, Benoist H, Levade T. Sphingolipids as modulators of cancer cell death: potential therapeutic targets. Biochimica Et Biophysica Acta. 1758: 2104-20. PMID 16925980 DOI: 10.1016/J.Bbamem.2006.05.024  0.436
2004 Jaffrezou JP, Laurent G. Ceramide : A New Target in Anticancer Research? Bulletin Du Cancer. 91: E133-61. PMID 15568227  0.305
2004 Dumontet C, Jaffrezou JP, Tsuchiya E, Duran GE, Chen G, Derry WB, Wilson L, Jordan MA, Sikic BI. Resistance to microtubule-targeted cytotoxins in a K562 leukemia cell variant associated with altered tubulin expression and polymerization. Bulletin Du Cancer. 91: E81-112. PMID 15568225  0.592
2004 Grazide S, Terrisse AD, Lerouge S, Laurent G, Jaffrézou JP. Cytoprotective effect of glucosylceramide synthase inhibition against daunorubicin-induced apoptosis in human leukemic cell lines. The Journal of Biological Chemistry. 279: 18256-61. PMID 14766899 DOI: 10.1074/Jbc.M314105200  0.505
2004 Jaffrézou J, Laurent G, Levade T. Ceramide in Regulation of Apoptosis Sub-Cellular Biochemistry. 36: 269-284. DOI: 10.1007/0-306-47931-1_14  0.456
2003 Bezombes C, Laurent G, Jaffrézou JP. Implication of raft microdomains in drug induced apoptosis. Current Medicinal Chemistry. Anti-Cancer Agents. 3: 263-70. PMID 12769772 DOI: 10.2174/1568011033482413  0.433
2003 Maestre N, Bezombes C, Plo I, Levade T, Lavelle F, Laurent G, Jaffrézou JP. Phosphatidylcholine-derived phosphatidic acid and diacylglycerol are involved in the signaling pathways activated by docetaxel. Journal of Experimental Therapeutics & Oncology. 3: 36-46. PMID 12724857 DOI: 10.1046/J.1359-4117.2003.01065.X  0.337
2003 Mas VM, Hernandez H, Plo I, Bezombes C, Maestre N, Quillet-Mary A, Filomenko R, Demur C, Jaffrézou JP, Laurent G. Protein kinase Czeta mediated Raf-1/extracellular-regulated kinase activation by daunorubicin. Blood. 101: 1543-50. PMID 12406911 DOI: 10.1182/Blood-2002-05-1585  0.355
2002 Bezombes C, de Thonel A, Apostolou A, Louat T, Jaffrézou JP, Laurent G, Quillet-Mary A. Overexpression of protein kinase Czeta confers protection against antileukemic drugs by inhibiting the redox-dependent sphingomyelinase activation. Molecular Pharmacology. 62: 1446-55. PMID 12435813 DOI: 10.1124/Mol.62.6.1446  0.475
2002 Terrisse AD, Bezombes C, Lerouge S, Laurent G, Jaffrézou JP. Daunorubicin- and Ara-C-induced interphasic apoptosis of human type II leukemia cells is caspase-8-independent. Biochimica Et Biophysica Acta. 1584: 99-103. PMID 12385892 DOI: 10.1016/S1388-1981(02)00297-4  0.452
2002 Grazide S, Maestre N, Veldman RJ, Bezombes C, Maddens S, Levade T, Laurent G, Jaffrézou JP. Ara-C- and daunorubicin-induced recruitment of Lyn in sphingomyelinase-enriched membrane rafts. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 1685-7. PMID 12206990 DOI: 10.1096/Fj.01-0794Fje  0.394
2002 Lecompte MF, Laurent G, Jaffrézou JP. Sphingomyelin content conditions insertion of daunorubicin within phosphatidylcholine monolayers. Febs Letters. 525: 141-4. PMID 12163177 DOI: 10.1016/S0014-5793(02)03063-6  0.339
2002 Maddens S, Charruyer A, Plo I, Dubreuil P, Berger S, Salles B, Laurent G, Jaffrézou JP. Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: implication in stem cell factor radioprotective effect. Blood. 100: 1294-301. PMID 12149210  0.36
2002 Jaffrézou JP, Laurent G, Levade T. Ceramide in regulation of apoptosis. Implication in multitoxicant resistance. Sub-Cellular Biochemistry. 36: 269-84. PMID 12037986  0.308
2002 Maddens S, Charruyer A, Plo I, Dubreuil P, Berger S, Salles B, Laurent G, Jaffrézou J. Kit signaling inhibits the sphingomyelin-ceramide pathway through PLCγ1: implication in stem cell factor radioprotective effect Blood. 100: 1294-1301. DOI: 10.1182/Blood.V100.4.1294.H81602001294_1294_1301  0.451
2001 Laurent G, Jaffrézou JP. Signaling pathways activated by daunorubicin. Blood. 98: 913-24. PMID 11493433 DOI: 10.1182/Blood.V98.4.913  0.37
2001 Bezombes C, Plo I, Mansat-De Mas V, Quillet-Mary A, Nègre-Salvayre A, Laurent G, Jaffrézou JP. Oxidative stress-induced activation of Lyn recruits sphingomyelinase and is requisite for its stimulation by Ara-C. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 1583-5. PMID 11427493 DOI: 10.1096/Fj.00-0787Fje  0.413
2001 Maestre N, Tritton TR, Laurent G, Jaffrézou JP. Cell surface-directed interaction of anthracyclines leads to cytotoxicity and nuclear factor kappaB activation but not apoptosis signaling. Cancer Research. 61: 2558-61. PMID 11289131  0.37
2001 Bezombes C, Ségui B, Cuvillier O, Bruno AP, Uro-Coste E, Gouazé V, Andrieu-Abadie N, Carpentier S, Laurent G, Salvayre R, Jaffrézou JP, Levade T. Lysosomal sphingomyelinase is not solicited for apoptosis signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 297-9. PMID 11156942 DOI: 10.1096/Fj.00-0466Fje  0.414
2001 Jaffrézou JP, Bruno AP, Moisand A, Levade T, Laurent G. Activation of a nuclear sphingomyelinase in radiation-induced apoptosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 123-133. PMID 11149900 DOI: 10.1096/Fj.00-0305Com  0.381
2000 Ségui B, Bezombes C, Uro-Coste E, Medin JA, Andrieu-Abadie N, Augé N, Brouchet A, Laurent G, Salvayre R, Jaffrézou JP, Levade T. Stress-induced apoptosis is not mediated by endolysosomal ceramide. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 36-47. PMID 10627278 DOI: 10.1096/Fasebj.14.1.36  0.399
1999 Levade T, Andrieu-Abadie N, Ségui B, Augé N, Chatelut M, Jaffrézou JP, Salvayre R. Sphingomyelin-degrading pathways in human cells role in cell signalling. Chemistry and Physics of Lipids. 102: 167-78. PMID 11001571 DOI: 10.1016/S0009-3084(99)00085-7  0.388
1999 Jaffrézou JP, Laurent G. [Role of lipid second messengers involved in the response of leukemic cells to anticancer drugs]. Journal De La SociéTé De Biologie. 193: 429-37. PMID 10689626  0.368
1999 Delpy E, Hatem SN, Andrieu N, de Vaumas C, Henaff M, Rücker-Martin C, Jaffrézou JP, Laurent G, Levade T, Mercadier JJ. Doxorubicin induces slow ceramide accumulation and late apoptosis in cultured adult rat ventricular myocytes. Cardiovascular Research. 43: 398-407. PMID 10536670 DOI: 10.1016/S0008-6363(99)00142-X  0.343
1999 Mansat-de Mas V, Bezombes C, Quillet-Mary A, Bettaïeb A, D'orgeix AD, Laurent G, Jaffrézou JP. Implication of radical oxygen species in ceramide generation, c-Jun N-terminal kinase activation and apoptosis induced by daunorubicin. Molecular Pharmacology. 56: 867-74. PMID 10531389 DOI: 10.1124/Mol.56.5.867  0.4
1999 Andrieu-Abadie N, Jaffrezou JP, Hatem S, Laurent G, Levade T, Mercadier JJ. L-carnitine prevents doxorubicin-induced apoptosis of cardiac myocytes: role of inhibition of ceramide generation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 13: 1501-10. PMID 10463940 DOI: 10.1096/Fasebj.13.12.1501  0.379
1999 Levade T, Jaffrézou JP. Signalling sphingomyelinases: which, where, how and why? Biochimica Et Biophysica Acta. 1438: 1-17. PMID 10216276 DOI: 10.1016/S1388-1981(99)00038-4  0.356
1999 Bettaïeb A, Plo I, Mansat-De Mas V, Quillet-Mary A, Levade T, Laurent G, Jaffrézou JP. Daunorubicin- and mitoxantrone-triggered phosphatidylcholine hydrolysis: implication in drug-induced ceramide generation and apoptosis. Molecular Pharmacology. 55: 118-25. PMID 9882705  0.358
1998 Bruno AP, Laurent G, Averbeck D, Demur C, Bonnet J, Bettaïeb A, Levade T, Jaffrézou JP. Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation. Cell Death and Differentiation. 5: 172-82. PMID 10200462 DOI: 10.1038/Sj.Cdd.4400330  0.45
1998 Jaffrézou JP, Maestre N, de Mas-Mansat V, Bezombes C, Levade T, Laurent G. Positive feedback control of neutral sphingomyelinase activity by ceramide. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 12: 999-1006. PMID 9707172 DOI: 10.1096/Fasebj.12.11.999  0.444
1998 Jaffrézou JP, Bettaïeb A, Levade T, Laurent G. Antitumor agent-induced apoptosis in myeloid leukemia cells: a controlled suicide. Leukemia & Lymphoma. 29: 453-63. PMID 9643559 DOI: 10.3109/10428199809050905  0.474
1998 Augé N, Escargueil-Blanc I, Lajoie-Mazenc I, Suc I, Andrieu-Abadie N, Pieraggi MT, Chatelut M, Thiers JC, Jaffrézou JP, Laurent G, Levade T, Nègre-Salvayre A, Salvayre R. Potential role for ceramide in mitogen-activated protein kinase activation and proliferation of vascular smooth muscle cells induced by oxidized low density lipoprotein. The Journal of Biological Chemistry. 273: 12893-900. PMID 9582320 DOI: 10.1074/Jbc.273.21.12893  0.374
1998 Bezombes C, Maestre N, Laurent G, Levade T, Bettaïeb A, Jaffrézou JP. Restoration of TNF-alpha-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 12: 101-9. PMID 9438415 DOI: 10.1096/Fasebj.12.1.101  0.408
1997 Mansat V, Laurent G, Levade T, Bettaïeb A, Jaffrézou JP. The protein kinase C activators phorbol esters and phosphatidylserine inhibit neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin. Cancer Research. 57: 5300-4. PMID 9393753  0.321
1997 Quillet-Mary A, Jaffrézou JP, Mansat V, Bordier C, Naval J, Laurent G. Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis. The Journal of Biological Chemistry. 272: 21388-95. PMID 9261153 DOI: 10.1074/Jbc.272.34.21388  0.351
1997 Mansat V, Bettaïeb A, Levade T, Laurent G, Jaffrézou JP. Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 11: 695-702. PMID 9240970 DOI: 10.1096/Fasebj.11.8.9240970  0.465
1996 Bettaieb A, Record M, Côme MG, Bras AC, Chap H, Laurent G, Jaffrézou JP. Opposite effects of tumor necrosis factor alpha on the sphingomyelin-ceramide pathway in two myeloid leukemia cell lines: role of transverse sphingomyelin distribution in the plasma membrane. Blood. 88: 1465-72. PMID 8695867 DOI: 10.1182/Blood.V88.4.1465.Bloodjournal8841465  0.387
1996 Jaffrézou JP, Levade T, Bettaïeb A, Andrieu N, Bezombes C, Maestre N, Vermeersch S, Rousse A, Laurent G. Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis. The Embo Journal. 15: 2417-24. PMID 8665849  0.363
1994 Laredo J, Huynh A, Muller C, Jaffrézou JP, Bailly JD, Cassar G, Laurent G, Demur C. Effect of the protein kinase C inhibitor staurosporine on chemosensitivity to daunorubicin of normal and leukemic fresh myeloid cells. Blood. 84: 229-37. PMID 7912555  0.366
1994 Muller C, Bailly JD, Goubin F, Laredo J, Jaffrézou JP, Bordier C, Laurent G. Verapamil decreases P-glycoprotein expression in multidrug-resistant human leukemic cell lines. International Journal of Cancer. Journal International Du Cancer. 56: 749-54. PMID 7906257 DOI: 10.1002/Ijc.2910560523  0.418
1994 Schlaifer D, Meyer K, Muller C, Attal M, Smith MT, Tamaki S, Weimels J, Pris J, Jaffrézou JP, Laurent G. Antisense inhibition of myeloperoxidase increases the sensitivity of the HL-60 cell line to vincristine. Leukemia. 8: 289-91. PMID 7905941  0.356
1994 Jaffrézou JP, Sikic BI, Laurent G. Cyclosporin A and cyclosporin SDZ PSC 833 enhance anti-CD5 ricin A-chain immunotoxins in human leukemic T cells. Blood. 83: 482-9. PMID 7506953  0.454
1993 Jaffrézou JP, Laurent G. The intriguing link between modulation of both multidrug resistance and ligand-toxin conjugate cytotoxicity. Febs Letters. 323: 191-7. PMID 8099019 DOI: 10.1016/0014-5793(93)81337-Y  0.348
1992 Jaffrézou JP, Levade T, Chatelain P, Laurent G. Modulation of subcellular distribution of doxorubicin in multidrug-resistant P388/ADR mouse leukemia cells by the chemosensitizer ((2-isopropyl-1-(4-[3-N-methyl-N-(3,4-dimethoxy-beta- phenethyl)amino]propyloxy)-benzenesulfonyl))indolizine. Cancer Research. 52: 6440-6. PMID 1423291  0.347
1991 Jaffrézou JP, Herbert JM, Levade T, Gau MN, Chatelain P, Laurent G. Reversal of multidrug resistance by calcium channel blocker SR33557 without photoaffinity labeling of P-glycoprotein. The Journal of Biological Chemistry. 266: 19858-64. PMID 1918089  0.304
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