| Year |
Citation |
Score |
| 2023 |
Rajaratnam V, Islam MM, Kub EF, Rajaratnam S, Kim KB, Rahman MT, Rashid F, Benko AM, Cook JM, Arnold LA, Mirza SP. Development and validation of an LC-MS/MS method for the determination of ARN14988, an acid ceramidase inhibitor, and its application to a pharmacokinetic study in a mouse model. Biomedical Chromatography : Bmc. e5754. PMID 37750452 DOI: 10.1002/bmc.5754 |
0.718 |
|
| 2023 |
Mitrović JR, Bjelošević Žiberna M, Vukadinović A, Knutson DE, Sharmin D, Kremenović A, Ahlin Grabnar P, Planinšek O, Lunter D, Cook JM, Savić MM, Savić SD. Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 189: 106557. PMID 37544333 DOI: 10.1016/j.ejps.2023.106557 |
0.653 |
|
| 2023 |
Huang YH, Lee MT, Hsueh HY, Knutson DE, Cook J, Mihovilovic MD, Sieghart W, Chiou LC. Cerebellar α6GABA Receptors as a Therapeutic Target for Essential Tremor: Proof-of-Concept Study with Ethanol and Pyrazoloquinolinones. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 36696034 DOI: 10.1007/s13311-023-01342-y |
0.678 |
|
| 2023 |
Mitrović JR, Divović-Matović B, Knutson DE, Petković M, Djorović D, Randjelović DV, Dobričić VD, Đoković JB, Lunter DJ, Cook JM, Savić MM, Savić SD. High amount of lecithin facilitates oral delivery of a poorly soluble pyrazoloquinolinone ligand formulated in lipid nanoparticles: Physicochemical, structural and pharmacokinetic performances. International Journal of Pharmaceutics. 633: 122613. PMID 36657554 DOI: 10.1016/j.ijpharm.2023.122613 |
0.658 |
|
| 2022 |
Pareek T, Overton JS, Nguyen LT, Rahman MT, Sharmin D, Cook JM, Platt DM. Modeling cue-exposure therapy for alcohol use disorder in rhesus monkeys: Effects of putative cognitive enhancers. Drug and Alcohol Dependence. 243: 109735. PMID 36549228 DOI: 10.1016/j.drugalcdep.2022.109735 |
0.717 |
|
| 2022 |
Lee MT, Mouri A, Kubota H, Lee HJ, Chang MH, Wu CY, Knutson DE, Mihovilovic M, Cook J, Sieghart W, Nabeshima T, Chiou LC. Targeting α6GABA receptors as a novel therapy for schizophrenia: A proof-of-concept preclinical study using various animal models. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 150: 113022. PMID 35483195 DOI: 10.1016/j.biopha.2022.113022 |
0.676 |
|
| 2022 |
Rahman MT, Tiruveedhula VVNPB, Stephen MR, Rallapalli SK, Pandey KP, Cook JM. Completion of the Total Synthesis of Several Bioactive Sarpagine/Macroline Alkaloids including the Important NF-κB Inhibitor -Methyltalpinine. Molecules (Basel, Switzerland). 27. PMID 35268836 DOI: 10.3390/molecules27051738 |
0.8 |
|
| 2022 |
Souza AJ, Cortez IL, Silva NR, Pedrazzi JFC, Domingos LB, Braga MS, Santos-Silva T, Del-Bel EA, Resstel LBM, Li G, Mian MY, Sharmin D, Guimarães FS, Cook JM, Gomes FV. Distinct sex-dependent behavioral responses induced by two positive allosteric modulators of alpha 5 subunit-containing GABA receptors. Behavioural Brain Research. 113832. PMID 35259414 DOI: 10.1016/j.bbr.2022.113832 |
0.622 |
|
| 2022 |
Witkin JM, Lippa A, Smith JL, Jin X, Ping X, Biggerstaff A, Kivell BM, Knutson DE, Sharmin D, Pandey KP, Mian MY, Cook JM, Cerne R. The imidazodiazepine, KRM-II-81: An example of a newly emerging generation of GABAkines for neurological and psychiatric disorders. Pharmacology, Biochemistry, and Behavior. 213: 173321. PMID 35041859 DOI: 10.1016/j.pbb.2021.173321 |
0.693 |
|
| 2021 |
Roni MSR, Zahn NM, Mikulsky BN, Webb DA, Mian MY, Knutson DE, Guthrie ML, Cook JM, Stafford DC, Arnold LA. Identification and Quantification of MIDD0301 metabolites. Current Drug Metabolism. PMID 34856893 DOI: 10.2174/1389200222666211202093841 |
0.665 |
|
| 2021 |
Cerne R, Lippa A, Poe MM, Smith JL, Jin X, Ping X, Golani LK, Cook JM, Witkin JM. GABAkines - Advances in the discovery, development, and commercialization of positive allosteric modulators of GABA receptors. Pharmacology & Therapeutics. 108035. PMID 34793859 DOI: 10.1016/j.pharmthera.2021.108035 |
0.643 |
|
| 2021 |
Arandelović J, Santrač A, Batinić B, Todorović L, Ahmed Khan MZ, Rashid F, Poe MM, Obradović A, Cook JM, Savić MM. Positive and Negative Selective Allosteric Modulators of α5 GABAA Receptors: Effects on Emotionality, Motivation, and Motor Function in the 5xFAD Model of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 34657887 DOI: 10.3233/JAD-215079 |
0.635 |
|
| 2021 |
Chandler CM, Reeves-Darby J, Jones SA, Li G, Rahman MT, Cook JM, Platt DM. Modulation of relapse-like drinking in male Sprague-Dawley rats by ligands targeting the α5GABA receptor. Neuropharmacology. 108785. PMID 34509495 DOI: 10.1016/j.neuropharm.2021.108785 |
0.639 |
|
| 2021 |
Santrač A, Batinić B, Stamenić TT, Aranđelović J, Sharmin D, Knutson DE, Cook JM, Savić MM. Positive modulation of α5GABAA receptors leads to dichotomous effects in rats on memory pattern and GABRA5 expression in prefrontal cortex and hippocampus. Behavioural Brain Research. 113578. PMID 34508769 DOI: 10.1016/j.bbr.2021.113578 |
0.656 |
|
| 2021 |
Duke AN, Tiruveedhula VVNPB, Sharmin D, Knutson DE, Cook JM, Platt DM, Rowlett JK. Tolerance and dependence following chronic alprazolam treatment in rhesus monkeys: Role of GABA receptor subtypes. Drug and Alcohol Dependence. 228: 108985. PMID 34500240 DOI: 10.1016/j.drugalcdep.2021.108985 |
0.705 |
|
| 2021 |
Mitrović JR, Divović-Matović B, Knutson DE, Đoković JB, Kremenović A, Dobričić VD, Randjelović DV, Pantelić I, Cook JM, Savić MM, Savić SD. Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach. Pharmaceutics. 13. PMID 34452149 DOI: 10.3390/pharmaceutics13081188 |
0.661 |
|
| 2021 |
Pandey KP, Rahman MT, Cook JM. Bisindole Alkaloids from the Species: Recent Isolation, Bioactivity, Biosynthesis, and Synthesis. Molecules (Basel, Switzerland). 26. PMID 34200196 DOI: 10.3390/molecules26113459 |
0.755 |
|
| 2021 |
Golani LK, Platt DM, Rüedi-Bettschen D, Edwanker C, Huang S, Poe MM, Furtmüller R, Sieghart W, Cook JM, Rowlett JK. 8-Substituted Triazolobenzodiazepines: and Pharmacology in Relation to Structural Docking at the α1 Subunit-Containing GABA Receptor. Frontiers in Pharmacology. 12: 625233. PMID 33959005 DOI: 10.3389/fphar.2021.625233 |
0.682 |
|
| 2021 |
Rivers-Auty J, Tapia VS, White CS, Daniels MJ, Drinkall S, Kennedy PT, Spence HG, Yu S, Green JP, Hoyle C, Cook J, Bradley A, Mather AE, Peters R, Tzeng TC, et al. Zinc status alters Alzheimer's disease progression through NLRP3-dependent inflammation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33597269 DOI: 10.1523/JNEUROSCI.1980-20.2020 |
0.721 |
|
| 2021 |
Rahman MA, Keck TM, Poe MM, Sharmin D, Cook JM, Fischer BD. Synergistic antihyperalgesic and antinociceptive effects of morphine and methyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate (MP-III-024): a positive allosteric modulator at α2GABA and α3GABA receptors. Psychopharmacology. PMID 33585961 DOI: 10.1007/s00213-021-05791-1 |
0.656 |
|
| 2021 |
Cadeddu R, Knutson DE, Mosher LJ, Loizou S, Odeh K, Fisher JL, Cook JM, Bortolato M. The α6 GABA Receptor Positive Allosteric Modulator DK-I-56-1 Reduces Tic-Related Behaviors in Mouse Models of Tourette Syndrome. Biomolecules. 11. PMID 33525455 DOI: 10.3390/biom11020175 |
0.706 |
|
| 2021 |
Fee C, Prevot TD, Misquitta K, Knutson DE, Li G, Mondal P, Cook JM, Banasr M, Sibille E. Behavioral deficits induced by somatostatin-positive GABA neuron silencing are rescued by alpha 5 GABA-A receptor potentiation. The International Journal of Neuropsychopharmacology. PMID 33438026 DOI: 10.1093/ijnp/pyab002 |
0.791 |
|
| 2020 |
Pandey KP, Khan ZA, Golani LK, Mondal P, Mian Y, Rashid F, Tiruveedhula VVNPB, Knutson DE, Sharmin D, Ahmed T, Rezvanian S, Zahn NM, Arnold LA, Witkin JM, Cook JM. Design, synthesis and characterization of novel gamma‑aminobutyric acid type A receptor ligands. Arkivoc : Free Online Journal of Organic Chemistry. 2020: 242-256. PMID 33642954 DOI: 10.24820/ark.5550190.p011.398 |
0.725 |
|
| 2020 |
Zahn NM, Mikulsky BN, Roni MSR, Yocum GT, Mian MY, Knutson DE, Cook JM, Emala CW, Stafford DC, Arnold LA. Nebulized MIDD0301 Reduces Airway Hyperresponsiveness in Moderate and Severe Murine Asthma Models. Acs Pharmacology & Translational Science. 3: 1381-1390. PMID 33344908 DOI: 10.1021/acsptsci.0c00180 |
0.668 |
|
| 2020 |
Pomeranz Krummel DA, Nasti TH, Kaluzova M, Kallay L, Bhattacharya D, Melms JC, Izar B, Xu M, Burnham A, Ahmed T, Li G, Lawson D, Kowalski J, Cao Y, Switchenko JM, ... ... Cook JM, et al. Melanoma Cell Intrinsic GABA Receptor Enhancement Potentiates Radiation and Immune Checkpoint Inhibitor Response by Promoting Direct and T Cell-Mediated Antitumor Activity. International Journal of Radiation Oncology, Biology, Physics. PMID 33289666 DOI: 10.1016/j.ijrobp.2020.10.025 |
0.593 |
|
| 2020 |
Tzeng HR, Lee MT, Fan PC, Knutson DE, Lai TH, Sieghart W, Cook J, Chiou LC. α6GABA Receptor Positive Modulators Alleviate Migraine-like Grimaces in Mice via Compensating GABAergic Deficits in Trigeminal Ganglia. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 33111258 DOI: 10.1007/s13311-020-00951-1 |
0.696 |
|
| 2020 |
Prevot TD, Sumitomo A, Tomoda T, Knutson DE, Li G, Mondal P, Banasr M, Cook JM, Sibille E. Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation. Cerebral Cortex (New York, N.Y. : 1991). PMID 33068001 DOI: 10.1093/cercor/bhaa310 |
0.781 |
|
| 2020 |
Knutson DE, Roni R, Mian Y, Cook JM, Stafford DC, Arnold LA. Improved scale-up synthesis and purification of clinical asthma candidate MIDD0301. Organic Process Research & Development. 24: 1467-1476. PMID 32952391 DOI: 10.1021/Acs.Oprd.0C00200 |
0.733 |
|
| 2020 |
Li G, Nieman AN, Mian MY, Zahn NM, Mikulsky BN, Poe MM, Methuku KR, Liu Y, Cook JM, Stafford DC, Arnold LA. A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABA Receptor. Molecules (Basel, Switzerland). 25. PMID 32854311 DOI: 10.3390/Molecules25173864 |
0.79 |
|
| 2020 |
Knutson DE, Smith JL, Ping X, Jin X, Golani LK, Li G, Tiruveedhula VVNPB, Rashid F, Mian MY, Jahan R, Sharmin D, Cerne R, Cook JM, Witkin JM. The Imidazodiazepine Anticonvulsant, KRM-II-81, Produces Novel, Non-diazepam-like Antiseizure Effects. Acs Chemical Neuroscience. PMID 32786313 DOI: 10.1021/Acschemneuro.0C00295 |
0.79 |
|
| 2020 |
Biggerstaff A, Kivell B, Smith JL, Mian MY, Golani LK, Rashid F, Sharmin D, Knutson DE, Cerne R, Cook JM, Witkin JM. The α2,3-selective potentiators of GABA receptors, KRM-II-81 and MP-III-80, produce anxiolytic-like effects, and block chemotherapy-induced hyperalgesia, in mice without tolerance development. Pharmacology, Biochemistry, and Behavior. 172996. PMID 32668266 DOI: 10.1016/J.Pbb.2020.172996 |
0.711 |
|
| 2020 |
Mitrović JR, Divović B, Knutson DE, Đoković JB, Vulić PJ, Randjelović DV, Dobričić VD, Čalija BR, Cook JM, Savić MM, Savić SD. Nanocrystal dispersion of DK-I-56-1, a poorly soluble pyrazoloquinolinone positive modulator of α6 GABA receptors: formulation approach toward improved in vivo performance. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 105432. PMID 32565331 DOI: 10.1016/J.Ejps.2020.105432 |
0.709 |
|
| 2020 |
Nieman AN, Li G, Zahn NM, Mian MY, Mikulsky BN, Hoffman DA, Wilcox TM, Kehoe AS, Luecke IW, Poe MM, Alvarez-Carbonell D, Cook JM, Stafford DC, Arnold LA. Targeting nitric oxide production in microglia with novel imidazodiazepines for non-sedative pain treatment. Acs Chemical Neuroscience. PMID 32511908 DOI: 10.1021/Acschemneuro.0C00324 |
0.791 |
|
| 2020 |
Tudeau L, Acuña MA, Albisetti GW, Neumann E, Ralvenius WT, Scheurer L, Poe M, Cook JM, Johannssen HC, Ulrich Zeilhofer H. Mice lacking spinal α2GABA receptors: Altered GABAergic neurotransmission, diminished GABAergic antihyperalgesia, and potential compensatory mechanisms preventing a hyperalgesic phenotype. Brain Research. 146889. PMID 32439345 DOI: 10.1016/J.Brainres.2020.146889 |
0.657 |
|
| 2020 |
Roni MSR, Li G, Mikulsky BN, Knutson DE, Mian MY, Zahn NM, Cook JM, Stafford DC, Arnold LA. The effects of pH on the structure and bioavailability of imidazobenzodiazepine-3-carboxylate MIDD0301. Molecular Pharmaceutics. PMID 32069056 DOI: 10.1021/Acs.Molpharmaceut.9B01210 |
0.772 |
|
| 2020 |
Prevot T, Li G, Knutson D, Mondal P, Mian Y, Guilloux J, Mendez-David I, David D, Cook J, Sibille E. Improved Cognitive Functions and Neurotrophic Effects of a Novel Molecule Enhancing α5-GABA-A Receptor Function in Adult or Aged Mice Biological Psychiatry. 87: S404. DOI: 10.1016/J.Biopsych.2020.02.1032 |
0.788 |
|
| 2019 |
McCusker P, Mian MY, Li G, Olp MD, Tiruveedhula VVNPB, Rashid F, Golani LK, Verma RS, Smith BC, Cook JM, Chan JD. Non-sedating benzodiazepines cause paralysis and tissue damage in the parasitic blood fluke Schistosoma mansoni. Plos Neglected Tropical Diseases. 13: e0007826. PMID 31730614 DOI: 10.1371/Journal.Pntd.0007826 |
0.648 |
|
| 2019 |
Witkin JM, Li G, Golani LK, Xiong W, Smith JL, Ping X, Rashid F, Jahan R, Cerne R, Cook JM, Jin X. The positive allosteric modulator of α2/3-containing GABAA receptors, KRM-II-81, is active in pharmaco-resistant models of epilepsy and reduces hyperexcitability after traumatic brain injury. The Journal of Pharmacology and Experimental Therapeutics. PMID 31694876 DOI: 10.1124/Jpet.119.260968 |
0.745 |
|
| 2019 |
Meng Z, Berro LF, Sawyer EK, Rüedi-Bettschen D, Cook JE, Li G, Platt DM, Cook JM, Rowlett JK. Evaluation of the anti-conflict, reinforcing, and sedative effects of YT-III-31, a ligand functionally selective for α3 subunit-containing GABA receptors. Journal of Psychopharmacology (Oxford, England). 269881119882803. PMID 31670615 DOI: 10.1177/0269881119882803 |
0.683 |
|
| 2019 |
Forkuo GS, Nieman AN, Kodali R, Zahn NM, Li G, Roni MSR, Stephen MR, Harris TW, Jahan R, Guthrie ML, Yu OB, Fisher JL, Yocum GT, Emala CW, Steeber DA, ... ... Cook JM, et al. Correction to "A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABA Receptors in the Lung". Molecular Pharmaceutics. PMID 31633359 DOI: 10.1021/acs.molpharmaceut.9b01053 |
0.729 |
|
| 2019 |
Witkin JM, Ping X, Cerne R, Mouser C, Jin X, Hobbs J, Tiruveedhula VVNPB, Li G, Jahan R, Rashid F, Kumar Golani L, Cook JM, Smith JL. The value of human epileptic tissue in the characterization and development of novel antiepileptic drugs:The example of CERC-611 and KRM-II-81. Brain Research. 146356. PMID 31369732 DOI: 10.1016/J.Brainres.2019.146356 |
0.749 |
|
| 2019 |
Prevot TD, Li G, Vidojevic A, Misquitta KA, Fee C, Santrac A, Knutson DE, Stephen MR, Kodali R, Zahn NM, Arnold LA, Scholze P, Fisher JL, Marković BD, Banasr M, ... Cook JM, et al. Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles. Molecular Neuropsychiatry. 5: 84-97. PMID 31192221 DOI: 10.1159/000496086 |
0.791 |
|
| 2019 |
Prevot TD, Li G, Cook JM, Sibille E. Insight into Novel Treatment for Cognitive Dysfunctions across Disorders. Acs Chemical Neuroscience. PMID 30920790 DOI: 10.1021/Acschemneuro.9B00148 |
0.657 |
|
| 2019 |
Berro LF, Rüedi-Bettschen D, Cook JE, Golani LK, Li G, Jahan R, Rashid F, Cook JM, Rowlett JK, Platt DM. GABA receptor subtypes and the abuse-related effects of ethanol in rhesus monkeys: Experiments with selective positive allosteric modulators. Alcoholism, Clinical and Experimental Research. PMID 30861153 DOI: 10.1111/Acer.14000 |
0.754 |
|
| 2019 |
Witkin JM, Cerne R, Davis PG, Freeman KB, do Carmo JM, Rowlett JK, Methuku KR, Okun A, Gleason SD, Li X, Krambis MJ, Poe M, Li G, Schkeryantz JM, Jahan R, ... ... Cook JM, et al. The α2,3-selective potentiator of GABA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats. Pharmacology, Biochemistry, and Behavior. PMID 30825491 DOI: 10.1016/J.Pbb.2019.02.013 |
0.802 |
|
| 2019 |
Kallay L, Keskin H, Ross A, Rupji M, Moody OA, Wang X, Li G, Ahmed T, Rashid F, Stephen MR, Cottrill KA, Nuckols TA, Xu M, Martinson DE, Tranghese F, ... ... Cook JM, et al. Modulating native GABA receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death. Journal of Neuro-Oncology. PMID 30725256 DOI: 10.1007/S11060-019-03115-0 |
0.662 |
|
| 2019 |
Zahn NM, Huber AT, Mikulsky BN, Stepanski ME, Kehoe AS, Li G, Schussman M, Rashid Roni MS, Kodali R, Cook JM, Stafford DC, Steeber DA, Arnold LA. MIDD0301 - A first-in-class anti-inflammatory asthma drug targets GABA receptors without causing systemic immune suppression. Basic & Clinical Pharmacology & Toxicology. PMID 30694594 DOI: 10.1111/Bcpt.13206 |
0.648 |
|
| 2019 |
Moerke MJ, Li G, Golani LK, Cook J, Negus SS. Effects of the α2/α3-subtype-selective GABAA receptor positive allosteric modulator KRM-II-81 on pain-depressed behavior in rats: comparison with ketorolac and diazepam. Behavioural Pharmacology. PMID 30640180 DOI: 10.1097/Fbp.0000000000000464 |
0.654 |
|
| 2019 |
Chandler CM, Reeves-Darby J, Jones SA, McDonald JA, Li G, Rahman MT, Cook JM, Platt DM. α5GABA subunit-containing receptors and sweetened alcohol cue-induced reinstatement and active sweetened alcohol self-administration in male rats. Psychopharmacology. PMID 30637435 DOI: 10.1007/S00213-018-5163-6 |
0.653 |
|
| 2019 |
Vasović D, Divović B, Treven M, Knutson DE, Steudle F, Scholze P, Obradović A, Fabjan J, Brković B, Sieghart W, Ernst M, Cook JM, Savić MM. Trigeminal neuropathic pain development and maintenance in rats are suppressed by a positive modulator of α6 GABA receptors. European Journal of Pain (London, England). PMID 30633839 DOI: 10.1002/Ejp.1365 |
0.725 |
|
| 2019 |
Kallay L, Keskin H, Ross A, Rupji M, Moody OA, Wang X, Li G, Ahmed T, Rashid F, Stephen MR, Cottrill KA, Nuckois A, Xu M, Martinson DE, Tranghese F, ... ... Cook JM, et al. Abstract 2623: Modulating native GABAA receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death Cancer Research. 79: 2623-2623. DOI: 10.1158/1538-7445.Am2019-2623 |
0.663 |
|
| 2019 |
Smith JL, Ping X, Jin X, Golani LK, Li G, Rashid F, Jahan R, Cook JM, Witkin JM. The Positive Allosteric Modulator of Alpha-2/3-Containing γ-Aminobutyric Acid Type A Receptors, KRM-II-81, Is Active in Pharmacoresistant Models of Epilepsy and in Human Epileptic Tissue Neurosurgery. 66. DOI: 10.1093/Neuros/Nyz310_697 |
0.755 |
|
| 2019 |
Pomeranz Krummel D, Nasti T, Izar B, Xu M, Lowder L, Press R, Kaluzova M, Kallay L, Rupji M, Burnham A, Li G, Ahmed T, Rosen H, Connolly E, Keskin H, ... ... Cook J, et al. EXTH-12. RADIATION ENHANCES MELANOMA RESPONSE TO IMMUNOTHERAPY AND SYNERGIZES WITH BENZODIAZEPINES TO PROMOTE ANTI-TUMOR ACTIVITY Neuro-Oncology. 21: vi84-vi84. DOI: 10.1093/Neuonc/Noz175.346 |
0.633 |
|
| 2019 |
Rahman M, Cook J. The Ambidextrous Pictet–Spengler Reaction: Access to the (+)- or (–)-Enantiomers of the Bioactive C-19 Methyl-Substituted Sarpagine/Macroline/Ajmaline Alkaloids from Either d- or l-Tryptophan Synthesis. 51: 1980-1988. DOI: 10.1055/S-0037-1610687 |
0.322 |
|
| 2019 |
Prevot T, Li G, Misquitta K, Fee C, Knutson D, Stephen MR, Kodali R, Zahn N, Arnold LA, Banasr M, Cook J, Sibille E. T117. Pro-Cognitive Properties of a Novel GABA-A Receptor Positive Modulator in Animal Models of Depression and Aging Biological Psychiatry. 85: S174. DOI: 10.1016/J.Biopsych.2019.03.440 |
0.784 |
|
| 2018 |
Li G, Stephen MR, Kodali R, Zahn NM, Poe MM, Tiruveedhula VVNPB, Huber AT, Schussman MK, Qualmann K, Panhans CM, Raddatz NJ, Baker DA, Prevot TD, Banasr M, Sibille E, ... ... Cook JM, et al. Synthesis of chiral GABA receptor subtype selective ligands as potential agents to treat schizophrenia as well as depression. Arkivoc : Free Online Journal of Organic Chemistry. 2018: 158-182. PMID 32774192 DOI: 10.24820/Ark.5550190.P010.460 |
0.791 |
|
| 2018 |
Li G, Golani LK, Jahan R, Rashid F, Cook JM. Improved Synthesis of Anxiolytic, Anticonvulsant and Antinociceptive α2/α3-GABA(A)ergic Receptor Subtype Selective Ligands as Promising Agents to Treat Anxiety, Epilepsy, as well as Neuropathic Pain. Synthesis. 50: 4124-4132. PMID 32773890 DOI: 10.1055/S-0037-1610211 |
0.781 |
|
| 2018 |
Neumann E, Rudolph U, Knutson DE, Li G, Cook JM, Hentschke H, Antkowiak B, Drexler B. Zolpidem Activation of Alpha 1-Containing GABA Receptors Selectively Inhibits High Frequency Action Potential Firing of Cortical Neurons. Frontiers in Pharmacology. 9: 1523. PMID 30687091 DOI: 10.3389/Fphar.2018.01523 |
0.798 |
|
| 2018 |
Yocum GT, Perez-Zoghbi JF, Danielsson J, Kuforiji AS, Zhang Y, Li G, Roni MSR, Kodali R, Stafford DC, Arnold LA, Cook JM, Emala CW. A Novel GABA Receptor Ligand MIDD0301 with Limited Blood-Brain Barrier Penetration Relaxes Airway Smooth Muscle Ex Vivo and In Vivo. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 30489155 DOI: 10.1152/Ajplung.00356.2018 |
0.665 |
|
| 2018 |
Fan PC, Lai TH, Hor CC, Lee MT, Huang P, Sieghart W, Ernst M, Knutson DE, Cook J, Chiou LC. The α6 subunit-containing GABA receptor: A novel drug target for inhibition of trigeminal activation. Neuropharmacology. PMID 30016665 DOI: 10.1016/J.Neuropharm.2018.07.017 |
0.732 |
|
| 2018 |
Batinić B, Stanković T, Stephen MR, Kodali R, Tiruveedhula VV, Li G, Scholze P, Marković BD, Obradović AL, Ernst M, Cook JM, Savić MM. Attaining in vivo selectivity of positive modulation of α3βγ2 GABA receptors in rats: A hard task! European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 29891214 DOI: 10.1016/J.Euroneuro.2018.05.014 |
0.685 |
|
| 2018 |
Witkin JM, Smith JL, Ping X, Gleason SD, Poe MM, Li G, Jin X, Hobbs J, Schkeryantz JM, McDermott JS, Alatorre AI, Siemian JN, Cramer JW, Airey DC, Methuku KR, ... ... Cook JM, et al. Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABA receptors: Improved bioavailability enhances anticonvulsant efficacy. Neuropharmacology. 137: 332-343. PMID 29778948 DOI: 10.1016/J.Neuropharm.2018.05.006 |
0.793 |
|
| 2018 |
Elgarf AA, Siebert DCB, Steudle F, Draxler A, Li G, Huang S, Cook JM, Ernst M, Scholze P. Different Benzodiazepines Bind with Distinct Binding Modes to GABA Receptors. Acs Chemical Biology. PMID 29767950 DOI: 10.1021/Acschembio.8B00144 |
0.794 |
|
| 2018 |
Duke AN, Meng Z, Platt DM, Atack JR, Dawson GR, Reynolds DS, Tiruveedhula VVNPB, Li G, Stephen MR, Sieghart W, Cook JM, Rowlett JK. Evidence that Sedative Effects of Benzodiazepines Involve Unexpected GABA Receptor Subtypes: Quantitative Observation Studies in Rhesus Monkeys. The Journal of Pharmacology and Experimental Therapeutics. PMID 29720564 DOI: 10.1124/Jpet.118.249250 |
0.685 |
|
| 2018 |
Methuku KR, Li X, Cerne R, Gleason SD, Schkeryantz JM, Tiruveedhula VVNPB, Golani LK, Li G, Poe MM, Rahman MT, Cook JM, Fisher JL, Witkin JM. An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABA receptors. Pharmacology, Biochemistry, and Behavior. PMID 29715490 DOI: 10.1016/J.Pbb.2018.04.009 |
0.79 |
|
| 2018 |
Forkuo GS, Nieman AN, Kodali R, Zahn NM, Li G, Rashid Roni S, Stephen MR, Harris TW, Jahan R, Guthrie ML, Yu OB, Fisher JL, Yocum GT, Emala CW, Steeber DA, ... ... Cook JM, et al. A novel orally available asthma drug candidate that reduces smooth muscle constriction and inflammation by targeting GABA(A) receptors in the lung. Molecular Pharmaceutics. PMID 29578347 DOI: 10.1021/Acs.Molpharmaceut.7B01013 |
0.754 |
|
| 2018 |
Chiou LC, Lee HJ, Ernst M, Huang WJ, Chou JF, Chen HL, Mouri A, Chen LC, Treven M, Mamiya T, Fan PC, Knutson DE, Witzigmann C, Cook J, Sieghart W, et al. Cerebellar α6 subunit-containing GABAreceptors: A novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders. British Journal of Pharmacology. PMID 29518821 DOI: 10.1111/Bph.14198 |
0.714 |
|
| 2018 |
Knutson DE, Kodali R, Divovic B, Treven M, Stephen MR, Zahn NM, Dobričić V, Huber AT, Meirelles MA, Verma RS, Wimmer L, Witzigmann C, Arnold LA, Chiou LC, Ernst M, ... ... Cook JM, et al. Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABAR) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability. Journal of Medicinal Chemistry. PMID 29481759 DOI: 10.1021/Acs.Jmedchem.7B01664 |
0.799 |
|
| 2018 |
Xu NZ, Ernst M, Treven M, Cerne R, Wakulchik M, Li X, Jones TM, Gleason SD, Morrow D, Schkeryantz JM, Rahman MT, Li G, Poe MM, Cook JM, Witkin JM. Negative allosteric modulation of alpha 5-containing GABAA receptors engenders antidepressant-like effects and selectively prevents age-associated hyperactivity in tau-depositing mice. Psychopharmacology. PMID 29374303 DOI: 10.1007/S00213-018-4832-9 |
0.787 |
|
| 2018 |
Li G, Stephen MR, Kodali R, Zahn NM, Poe MM, Tiruveedhula VVNPB, Huber AT, Schussman MK, Qualmann K, Panhans CM, Raddatz NJ, Baker DA, Prevot TD, Banasr M, Sibille E, ... ... Cook JM, et al. Synthesis of chiral GABAA receptor subtype selective ligands as potential agents to treat schizophrenia as well as depression Arkivoc. 2018: 158-182. DOI: 10.24820/ark.5550190.p010.460 |
0.765 |
|
| 2018 |
Kallay L, Keskin H, Ross A, Moody O, Cottrill K, Nuckols A, Li G, Ahmed T, Rashid F, Stephen M, Xu M, Martinson D, Macdonald T, Kowalski J, Wang X, ... ... Cook J, et al. PDTM-45. POSITIVE MODULATION OF NATIVE GABAA RECEPTORS IN MEDULLOBLASTOMA CANCER CELLS WITH BENZODIAZEPINES INDUCES RAPID MITOCHONDRIAL FRAGMENTATION AND TP53-DEPENDENT, CELL CYCLE-INDEPENDENT APOPTOSIS Neuro-Oncology. 20: vi213-vi213. DOI: 10.1093/Neuonc/Noy148.884 |
0.635 |
|
| 2018 |
Prevot T, Li G, Vidojevic A, Santrac A, Misquitta K, Hu X, Knutson D, Arnold L, Fisher J, Banasr M, Cook J, Savic M, Sibille E. S162. Antidepressant and Pro-Cognitive Effects of a Novel Series of GABA-A Receptor Positive Allosteric Modulators With α5 Subunit Efficacy Properties Biological Psychiatry. 83: S411. DOI: 10.1016/J.Biopsych.2018.02.1054 |
0.799 |
|
| 2018 |
Rahman MT, Cook JM. Unprecedented Stereocontrol in the Synthesis of 1,2,3-Trisubstituted Tetrahydro-β-carbolines through an Asymmetric Pictet-Spengler Reaction towards Sarpagine-Type Indole Alkaloids European Journal of Organic Chemistry. 2018: 3224-3229. DOI: 10.1002/Ejoc.201800600 |
0.327 |
|
| 2017 |
Rahman MT, Deschamps JR, Imler GH, Cook JM. Total Synthesis of Sarpagine-Related Bioactive Indole Alkaloids. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29244896 DOI: 10.1002/Chem.201705575 |
0.355 |
|
| 2017 |
Schwan WR, Polanowski R, Dunman PM, Medina-Bielski S, Lane M, Rott M, Lipker L, Wescott A, Monte A, Cook JM, Baumann DD, Tiruveedhula VVNPB, Witzigmann CM, Mikel C, Rahman MT. Identification of Staphylococcus aureus Cellular Pathways Affected by the Stilbenoid Lead Drug SK-03-92 Using a Microarray. Antibiotics (Basel, Switzerland). 6. PMID 28892020 DOI: 10.3390/Antibiotics6030017 |
0.766 |
|
| 2017 |
Stephen MR, Rahman MT, Tiruveedhula VVNPB, Fonseca GO, Deschamps JR, Cook JM. Concise Total Synthesis of (-)-Affinisine Oxindole, (+)-Isoalstonisine, (+)-Alstofoline, (-)-Macrogentine, (+)-Na-Demethylalstonisine, (-)-Alstonoxine A and (+)-Alstonisine. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28875520 DOI: 10.1002/Chem.201703572 |
0.769 |
|
| 2017 |
Meyer MAA, Corcoran KA, Chen HJ, Gallego S, Li G, Tiruveedhula VV, Cook JM, Radulovic J. Neurobiological correlates of state-dependent context fear. Learning & Memory (Cold Spring Harbor, N.Y.). 24: 385-391. PMID 28814463 DOI: 10.1101/Lm.045542.117 |
0.638 |
|
| 2017 |
Batinić B, Santrač A, Jančić I, Li G, Vidojević A, Marković B, Cook JM, Savić MM. Positive modulation of α5 GABAA receptors in preadolescence prevents reduced locomotor response to amphetamine in adult female but not male rats prenatally exposed to lipopolysaccharide. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 61: 31-39. PMID 28610974 DOI: 10.1016/J.Ijdevneu.2017.06.001 |
0.645 |
|
| 2017 |
Witkin JM, Cerne R, Wakulchik M, S J, Gleason SD, Jones TM, Li G, Arnold LA, Li JX, Schkeryantz JM, Methuku KR, Cook JM, Poe MM. Further evaluation of the potential anxiolytic activity of imidazo[1,5-a][1,4]diazepin agents selective for α2/3-containing GABAA receptors. Pharmacology, Biochemistry, and Behavior. PMID 28442369 DOI: 10.1016/J.Pbb.2017.04.009 |
0.797 |
|
| 2017 |
Forkuo GS, Nieman AN, Yuan NY, Kodali R, Yu OB, Zahn NM, Jahan R, Li G, Stephen MR, Guthrie ML, Poe MM, Hartzler BD, Harris TW, Yocum GT, Emala CW, ... ... Cook JM, et al. Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABAA Receptor Modulators. Molecular Pharmaceutics. PMID 28440659 DOI: 10.1021/Acs.Molpharmaceut.7B00183 |
0.788 |
|
| 2017 |
Schwienteck KL, Li G, Poe MM, Cook JM, Banks ML, Stevens Negus S. Abuse-related effects of subtype-selective GABAA receptor positive allosteric modulators in an assay of intracranial self-stimulation in rats. Psychopharmacology. PMID 28365836 DOI: 10.1007/S00213-017-4615-8 |
0.77 |
|
| 2017 |
Fischer BD, Schlitt RJ, Hamade BZ, Rehman S, Ernst M, Poe MM, Li G, Kodali R, Arnold LA, Cook JM. Pharmacological and antihyperalgesic properties of the novel α2/3 preferring GABAA receptor ligand MP-III-024. Brain Research Bulletin. PMID 28267561 DOI: 10.1016/J.Brainresbull.2017.03.001 |
0.801 |
|
| 2017 |
Lewter LA, Fisher JL, Siemian JN, Methuku KR, Poe MM, Cook JM, Li JX. Antinociceptive effects of a novel α2/α3-subtype selective GABAA receptor positive allosteric modulator. Acs Chemical Neuroscience. PMID 28150939 DOI: 10.1021/Acschemneuro.6B00447 |
0.678 |
|
| 2017 |
Kallay L, Ross A, Moody O, Li G, Cook J, MacDonald T, Jenkins A, Krummel DP, Sengupta S. PATH-50. UNDERSTANDING THE MECHANISM OF BENZODIAZEPINE MEDIATED CELL DEATH IN GABRA5 OVEREXPRESSING GROUP 3 MEDULLOBLASTOMAS Neuro-Oncology. 19: vi182-vi182. DOI: 10.1093/Neuonc/Nox168.739 |
0.615 |
|
| 2017 |
Arnold L, Forkuo G, Nieman A, Yu OB, Guthrie ML, Kodali R, Yuan N, Jahan R, Stephen MS, Emala CW, Yocum GT, Cook JM, Grayson MH. New Oral Treatments for Asthma through Tissue-Specific Modulation of the GABAA Receptor Journal of Allergy and Clinical Immunology. 139: AB9. DOI: 10.1016/J.Jaci.2016.12.083 |
0.587 |
|
| 2016 |
Poe MM, Methuku KR, Li G, Verma AR, Teske KA, Stafford DC, Arnold LA, Cramer JW, Jones TM, Cerne R, Krambis MJ, Witkin JM, Jambrina E, Rehman S, Ernst M, ... Cook JM, et al. Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy. Journal of Medicinal Chemistry. 59: 10800-10806. PMID 27933953 DOI: 10.1021/Acs.Jmedchem.6B01332 |
0.785 |
|
| 2016 |
Piantadosi SC, French BJ, Poe MM, Timić T, Marković BD, Pabba M, Seney ML, Oh H, Orser BA, Savić MM, Cook JM, Sibille E. Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABAA Receptor Positive Allosteric Modulator. Frontiers in Pharmacology. 7: 446. PMID 27920723 DOI: 10.3389/Fphar.2016.00446 |
0.66 |
|
| 2016 |
Jahan R, Stephen MR, Forkuo GS, Kodali R, Guthrie ML, Nieman AN, Yuan NY, Zahn NM, Poe MM, Li G, Yu OB, Yocum GT, Emala CW, Stafford DC, Cook JM, et al. Optimization of substituted imidazobenzodiazepines as novel asthma treatments. European Journal of Medicinal Chemistry. 126: 550-560. PMID 27915170 DOI: 10.1016/J.Ejmech.2016.11.045 |
0.786 |
|
| 2016 |
Holtyn AF, Tiruveedhula VV, Stephen MR, Cook JM, Weerts EM. Effects of the benzodiazepine GABAA α1-preferring antagonist 3-isopropoxy-β-carboline hydrochloride (3-ISOPBC) on alcohol seeking and self-administration in baboons. Drug and Alcohol Dependence. 170: 25-31. PMID 27865151 DOI: 10.1016/J.Drugalcdep.2016.10.036 |
0.32 |
|
| 2016 |
Rahman MT, Tiruveedhula VV, Cook JM. Synthesis of Bisindole Alkaloids from the Apocynaceae Which Contain a Macroline or Sarpagine Unit: A Review. Molecules (Basel, Switzerland). 21. PMID 27854259 DOI: 10.3390/Molecules21111525 |
0.764 |
|
| 2016 |
Stamenić TT, Poe MM, Rehman S, Santrač A, Divović B, Scholze P, Ernst M, Cook JM, Savić MM. Ester to amide substitution improves selectivity, efficacy and kinetic behavior of a benzodiazepine positive modulator of GABAA receptors containing the α5 subunit. European Journal of Pharmacology. PMID 27639297 DOI: 10.1016/J.Ejphar.2016.09.016 |
0.694 |
|
| 2016 |
Yuan NY, Poe MM, Witzigmann C, Cook JM, Stafford D, Arnold LA. Characterization of GABAA receptor ligands with automated patch-clamp using human neurons derived from pluripotent stem cells. Journal of Pharmacological and Toxicological Methods. PMID 27544543 DOI: 10.1016/J.Vascn.2016.08.006 |
0.775 |
|
| 2016 |
Rahman MT, Deschamps JR, Imler GH, Schwabacher AW, Cook JM. Total Synthesis of Macrocarpines D and E via an Enolate-Driven Copper-Mediated Cross-Coupling Process: Replacement of Catalytic Palladium with Copper Iodide. Organic Letters. PMID 27526647 DOI: 10.1021/Acs.Orglett.6B01526 |
0.309 |
|
| 2016 |
Jonas O, Calligaris D, Methuku KR, Poe MM, Francois JP, Tranghese F, Changelian A, Sieghart W, Ernst M, Krummel DA, Cook JM, Pomeroy SL, Cima M, Agar NY, Langer R, et al. First In Vivo Testing of Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development. Journal of Biomedical Nanotechnology. 12: 1297-302. PMID 27319222 DOI: 10.1166/Jbn.2016.2262 |
0.666 |
|
| 2016 |
Forkuo GS, Guthrie ML, Yuan NY, Nieman AN, Kodali R, Jahan R, Yocum GT, Treven M, Stephen MR, Poe MM, Li G, Yu OB, Hartzler BD, Zahn NM, Ernst M, ... ... Cook JM, et al. Development of GABAA Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma treatments. Molecular Pharmaceutics. PMID 27120014 DOI: 10.1021/Acs.Molpharmaceut.6B00159 |
0.798 |
|
| 2016 |
Heise C, Taha E, Murru L, Ponzoni L, Cattaneo A, Guarnieri FC, Montani C, Mossa A, Vezzoli E, Ippolito G, Zapata J, Barrera I, Ryazanov AG, Cook J, Poe M, et al. eEF2K/eEF2 Pathway Controls the Excitation/Inhibition Balance and Susceptibility to Epileptic Seizures. Cerebral Cortex (New York, N.Y. : 1991). PMID 27005990 DOI: 10.1093/Cercor/Bhw075 |
0.64 |
|
| 2016 |
Namjoshi OA, Cook JM. Sarpagine and Related Alkaloids. The Alkaloids. Chemistry and Biology. 76: 63-169. PMID 26827883 DOI: 10.1016/Bs.Alkal.2015.08.002 |
0.313 |
|
| 2016 |
Arnold LA, Forkuo GS, Nieman AN, Yu OB, Guthrie ML, Yuan NY, Kodali R, Jahan R, Emala CW, Cook JM, Stafford DC, Grayson MH. A New Pharmacological Approach for Asthma through Tissue-Specific Modulation of the GABA(A) Receptor Journal of Allergy and Clinical Immunology. 137: AB393. DOI: 10.1016/J.Jaci.2015.12.1218 |
0.607 |
|
| 2015 |
Schwan WR, Kolesar JM, Kabir MS, Elder EJ, Williams JB, Minerath R, Cook JM, Witzigmann CM, Monte A, Flaherty T. Pharmacokinetic/Toxicity Properties of the New Anti-Staphylococcal Lead Compound SK-03-92. Antibiotics (Basel, Switzerland). 4: 617-626. PMID 26877886 DOI: 10.3390/Antibiotics4040617 |
0.769 |
|
| 2015 |
Clayton T, Poe MM, Rallapalli S, Biawat P, Savić MM, Rowlett JK, Gallos G, Emala CW, Kaczorowski CC, Stafford DC, Arnold LA, Cook JM. A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model. International Journal of Medicinal Chemistry. 2015: 430248. PMID 26682068 DOI: 10.1155/2015/430248 |
0.808 |
|
| 2015 |
Botta P, Demmou L, Kasugai Y, Markovic M, Xu C, Fadok JP, Lu T, Poe MM, Xu L, Cook JM, Rudolph U, Sah P, Ferraguti F, Lüthi A. Corrigendum: Regulating anxiety with extrasynaptic inhibition. Nature Neuroscience. 18: 1862. PMID 26605888 DOI: 10.1038/Nn1215-1862A |
0.626 |
|
| 2015 |
Fischer BD, Platt DM, Rallapalli SK, Namjoshi OA, Cook JM, Rowlett JK. Antagonism of triazolam self-administration in rhesus monkeys responding under a progressive-ratio schedule: In vivo apparent pA2 analysis. Drug and Alcohol Dependence. PMID 26596587 DOI: 10.1016/J.Drugalcdep.2015.10.026 |
0.745 |
|
| 2015 |
Yocum GT, Gallos G, Zhang Y, Jahan R, Stephen MR, Varagic Z, Puthenkalam R, Ernst M, Cook JM, Emala CW. Targeting the GABAA Receptor α4 Subunit in Airway Smooth Muscle to Alleviate Bronchoconstriction. American Journal of Respiratory Cell and Molecular Biology. PMID 26405827 DOI: 10.1165/Rcmb.2015-0176Oc |
0.622 |
|
| 2015 |
Botta P, Demmou L, Kasugai Y, Markovic M, Xu C, Fadok JP, Lu T, Poe MM, Xu L, Cook JM, Rudolph U, Sah P, Ferraguti F, Lüthi A. Regulating anxiety with extrasynaptic inhibition. Nature Neuroscience. PMID 26322928 DOI: 10.1038/Nn.4102 |
0.642 |
|
| 2015 |
Timić Stamenić T, Joksimović S, Biawat P, Stanković T, Marković B, Cook JM, Savić MM. Negative modulation of α5 GABAA receptors in rats may partially prevent memory impairment induced by MK-801, but not amphetamine- or MK-801-elicited hyperlocomotion. Journal of Psychopharmacology (Oxford, England). PMID 26105958 DOI: 10.1177/0269881115590601 |
0.305 |
|
| 2015 |
Gallos G, Yocum GT, Siviski ME, Yim PD, Fu XW, Poe MM, Cook JM, Harrison N, Perez-Zoghbi J, Emala CW. Selective targeting of the α5-subunit of GABAA receptors relaxes airway smooth muscle and inhibits cellular calcium handling. American Journal of Physiology. Lung Cellular and Molecular Physiology. 308: L931-42. PMID 25659897 DOI: 10.1152/Ajplung.00107.2014 |
0.73 |
|
| 2015 |
Richetto J, Labouesse MA, Poe MM, Cook JM, Grace AA, Riva MA, Meyer U. Behavioral effects of the benzodiazepine-positive allosteric modulator SH-053-2'F-S-CH₃ in an immune-mediated neurodevelopmental disruption model. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 18. PMID 25636893 DOI: 10.1093/Ijnp/Pyu055 |
0.671 |
|
| 2015 |
Fonseca GO, Wang ZJ, Namjoshi OA, Deschamps JR, Cook JM. First stereospecific total synthesis of (-)-affinisine oxindole as well as facile entry into the C(7)-diastereomeric chitosenine stereochemistry Tetrahedron Letters. 56: 3052-3056. DOI: 10.1016/J.Tetlet.2014.11.036 |
0.363 |
|
| 2015 |
Rowlett J, Duke AN, Platt D, Namjoshi OA, Poe M, Tiruveedhula PB, Cook J. Evidence for sedative effects of benzodiazepines involving unexpected GABA A receptor subtypes Drug and Alcohol Dependence. 156: e194. DOI: 10.1016/J.Drugalcdep.2015.07.523 |
0.682 |
|
| 2015 |
Fischer BD, Kroll C, Poe M, Cook JM. Effects of HZ-166, a novel a2 and a3 subunit-containing GABAA receptor agonist, on inflammatory pain and operant behavior in mice Drug and Alcohol Dependence. 146: e278. DOI: 10.1016/J.Drugalcdep.2014.09.223 |
0.653 |
|
| 2014 |
Hackett CS, Quigley DA, Wong RA, Chen J, Cheng C, Song YK, Wei JS, Pawlikowska L, Bao Y, Goldenberg DD, Nguyen K, Gustafson WC, Rallapalli SK, Cho YJ, Cook JM, et al. Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma. Cell Reports. 9: 1034-46. PMID 25437558 DOI: 10.1016/J.Celrep.2014.09.046 |
0.722 |
|
| 2014 |
Edwankar RV, Edwankar CR, Deschamps JR, Cook JM. General strategy for synthesis of C-19 methyl-substituted sarpagine/macroline/ajmaline indole alkaloids including total synthesis of 19(S),20(R)-dihydroperaksine, 19(S),20(R)-dihydroperaksine-17-al, and peraksine. The Journal of Organic Chemistry. 79: 10030-48. PMID 25247616 DOI: 10.1021/Jo5016163 |
0.801 |
|
| 2014 |
Sidhu PS, Nassif N, McCallum MM, Teske K, Feleke B, Yuan NY, Nandhikonda P, Cook JM, Singh RK, Bikle DD, Arnold LA. Development of novel Vitamin D Receptor-Coactivator Inhibitors. Acs Medicinal Chemistry Letters. 5: 199-204. PMID 24799995 DOI: 10.1021/Ml400462J |
0.314 |
|
| 2014 |
Rallapalli SK, Namjoshi OA, Tiruveedhula VV, Deschamps JR, Cook JM. Stereospecific total synthesis of the indole alkaloid ervincidine. Establishment of the C-6 hydroxyl stereochemistry. The Journal of Organic Chemistry. 79: 3776-80. PMID 24697213 DOI: 10.1021/Jo402692U |
0.707 |
|
| 2014 |
KovaÄević J, Timić T, Tiruveedhula VV, Batinić B, Namjoshi OA, Milić M, Joksimović S, Cook JM, Savić MM. Duration of treatment and activation of α1-containing GABAA receptors variably affect the level of anxiety and seizure susceptibility after diazepam withdrawal in rats. Brain Research Bulletin. 104: 1-6. PMID 24695241 DOI: 10.1016/J.Brainresbull.2014.03.002 |
0.309 |
|
| 2014 |
McMurray KM, Distler MG, Sidhu PS, Cook JM, Arnold LA, Palmer AA, Plant LD. Glo1 inhibitors for neuropsychiatric and anti-epileptic drug development. Biochemical Society Transactions. 42: 461-7. PMID 24646261 DOI: 10.1042/Bst20140027 |
0.305 |
|
| 2014 |
Obradović ALj, Joksimović S, Poe MM, Ramerstorfer J, Varagic Z, Namjoshi O, Batinić B, Radulović T, Marković B, Roth BL, Sieghart W, Cook JM, Savić MM. Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects. Brain Research. 1554: 36-48. PMID 24472579 DOI: 10.1016/J.Brainres.2014.01.036 |
0.693 |
|
| 2014 |
Gill KM, Cook JM, Poe MM, Grace AA. Prior antipsychotic drug treatment prevents response to novel antipsychotic agent in the methylazoxymethanol acetate model of schizophrenia. Schizophrenia Bulletin. 40: 341-50. PMID 24464874 DOI: 10.1093/Schbul/Sbt236 |
0.649 |
|
| 2014 |
Sawyer EK, Moran C, Sirbu MH, Szafir M, Van Linn M, Namjoshi O, Phani Babu Tiruveedhula VV, Cook JM, Platt DM. Little evidence of a role for the α1GABAA subunit-containing receptor in a rhesus monkey model of alcohol drinking. Alcoholism, Clinical and Experimental Research. 38: 1108-17. PMID 24330519 DOI: 10.1111/Acer.12320 |
0.76 |
|
| 2014 |
Rae CD, Davidson JE, Maher AD, Rowlands BD, Kashem MA, Nasrallah FA, Rallapalli SK, Cook JM, Balcar VJ. Ethanol, not detectably metabolized in brain, significantly reduces brain metabolism, probably via action at specific GABA(A) receptors and has measureable metabolic effects at very low concentrations. Journal of Neurochemistry. 129: 304-14. PMID 24313287 DOI: 10.1111/Jnc.12634 |
0.716 |
|
| 2014 |
Sengupta S, Weeraratne SD, Sun H, Phallen J, Rallapalli SK, Teider N, Kosaras B, Amani V, Pierre-Francois J, Tang Y, Nguyen B, Yu F, Schubert S, Balansay B, Mathios D, ... ... Cook JM, et al. α5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth. Acta Neuropathologica. 127: 593-603. PMID 24196163 DOI: 10.1007/S00401-013-1205-7 |
0.731 |
|
| 2014 |
Obradović LA, Joksimović S, Poe MM, Timić T, Cook JM, Savić MM. Delayed behavioral effects of SH-I-048A, a novel nonselective positive modulator of GABAA receptors, after peripheral nerve injury in rats. Acta Veterinaria-Beograd. 64: 189-199. DOI: 10.2478/Acve-2014-0018 |
0.651 |
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| 2014 |
Jonas O, Sengupta S, Calligaris D, Poe M, Methuku K, Francois JP, Cook J, Agar N, Pomeroy S, Langer R. ET-24 * A NOVEL TROJAN HORSE FOR IN-VIVO SENSITIVITY TESTING OF MEDULLOBLASTOMA THERAPIES Neuro-Oncology. 16: v84-v84. DOI: 10.1093/Neuonc/Nou255.24 |
0.677 |
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| 2014 |
Richetto J, Labouesse MA, Poe MM, Cook JM, Grace AA, Riva MA, Meyer U. Poster #M240 BEHAVIORAL EFFECTS OF THE NOVEL BENZODIAZEPINE POSITIVE ALLOSTERIC MODULATOR SH-053-2′F-S-CH3 IN AN IMMUNE-MEDIATED NEURODEVELOPMENTAL DISRUPTION MODEL Schizophrenia Research. 153: S277. DOI: 10.1016/S0920-9964(14)70790-X |
0.633 |
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| 2014 |
Sawyer EK, Fischer B, Meng Z, Poe M, Namjoshi O, Cook J, Rowlett J. Role of α3GABAA receptor modulation in the anti-conflict effects of benzodiazepine-type drugs in monkeys Drug and Alcohol Dependence. 140: e196-e197. DOI: 10.1016/J.Drugalcdep.2014.02.548 |
0.663 |
|
| 2013 |
Huang CC, Monte A, Cook JM, Kabir MS, Peterson KP. Zebrafish heart failure models for the evaluation of chemical probes and drugs. Assay and Drug Development Technologies. 11: 561-72. PMID 24351044 DOI: 10.1089/Adt.2013.548 |
0.586 |
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| 2013 |
Tiruveedhula VV, Witzigmann CM, Verma R, Kabir MS, Rott M, Schwan WR, Medina-Bielski S, Lane M, Close W, Polanowski RL, Sherman D, Monte A, Deschamps JR, Cook JM. Design and synthesis of novel antimicrobials with activity against Gram-positive bacteria and mycobacterial species, including M. tuberculosis. Bioorganic & Medicinal Chemistry. 21: 7830-40. PMID 24200931 DOI: 10.1016/J.Bmc.2013.10.011 |
0.775 |
|
| 2013 |
Soto PL, Ator NA, Rallapalli SK, Biawat P, Clayton T, Cook JM, Weed MR. Allosteric modulation of GABA(A) receptor subtypes:effects on visual recognition and visuospatial working memory in rhesus monkeys [corrected]. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 2315-25. PMID 23722241 DOI: 10.1038/Npp.2013.137 |
0.714 |
|
| 2013 |
Edwankar CR, Edwankar RV, Namjoshi OA, Liao X, Cook JM. Stereospecific approach to the synthesis of ring-A oxygenated sarpagine indole alkaloids. Total synthesis of the dimeric indole alkaloid P-(+)-dispegatrine and six other monomeric indole alkaloids. The Journal of Organic Chemistry. 78: 6471-87. PMID 23721107 DOI: 10.1021/Jo400469T |
0.799 |
|
| 2013 |
Joksimović S, Varagic Z, KovaÄević J, Van Linn M, Milić M, Rallapalli S, Timić T, Sieghart W, Cook JM, Savić MM. Insights into functional pharmacology of α₠GABA(A) receptors: how much does partial activation at the benzodiazepine site matter? Psychopharmacology. 230: 113-23. PMID 23685860 DOI: 10.1007/S00213-013-3143-4 |
0.801 |
|
| 2013 |
Varagic Z, Ramerstorfer J, Huang S, Rallapalli S, Sarto-Jackson I, Cook J, Sieghart W, Ernst M. Subtype selectivity of α+β- site ligands of GABAA receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors. British Journal of Pharmacology. 169: 384-99. PMID 23472935 DOI: 10.1111/Bph.12153 |
0.805 |
|
| 2013 |
Varagic Z, Wimmer L, Schnürch M, Mihovilovic MD, Huang S, Rallapalli S, Cook JM, Mirheydari P, Ecker GF, Sieghart W, Ernst M. Identification of novel positive allosteric modulators and null modulators at the GABAA receptor α+β- interface. British Journal of Pharmacology. 169: 371-83. PMID 23472852 DOI: 10.1111/Bph.12151 |
0.8 |
|
| 2013 |
Drexler B, Zinser S, Huang S, Poe MM, Rudolph U, Cook JM, Antkowiak B. Enhancing the function of alpha5-subunit-containing GABAA receptors promotes action potential firing of neocortical neurons during up-states. European Journal of Pharmacology. 703: 18-24. PMID 23380687 DOI: 10.1016/J.Ejphar.2013.01.034 |
0.792 |
|
| 2013 |
Fischer BD, Teixeira LP, van Linn ML, Namjoshi OA, Cook JM, Rowlett JK. Role of gamma-aminobutyric acid type A (GABAA) receptor subtypes in acute benzodiazepine physical dependence-like effects: evidence from squirrel monkeys responding under a schedule of food presentation. Psychopharmacology. 227: 347-54. PMID 23354533 DOI: 10.1007/S00213-013-2975-2 |
0.773 |
|
| 2013 |
Makaron L, Moran CA, Namjoshi O, Rallapalli S, Cook JM, Rowlett JK. Cognition-impairing effects of benzodiazepine-type drugs: role of GABAA receptor subtypes in an executive function task in rhesus monkeys. Pharmacology, Biochemistry, and Behavior. 104: 62-8. PMID 23290931 DOI: 10.1016/J.Pbb.2012.12.018 |
0.722 |
|
| 2013 |
Kaminski BJ, Van Linn ML, Cook JM, Yin W, Weerts EM. Effects of the benzodiazepine GABAA α1-preferring ligand, 3-propoxy-β-carboline hydrochloride (3-PBC), on alcohol seeking and self-administration in baboons. Psychopharmacology. 227: 127-36. PMID 23271191 DOI: 10.1007/S00213-012-2946-Z |
0.771 |
|
| 2013 |
Milić M, Timić T, Joksimović S, Biawat P, Rallapalli S, Divljaković J, Radulović T, Cook JM, Savić MM. PWZ-029, an inverse agonist selective for α₅ GABAA receptors, improves object recognition, but not water-maze memory in normal and scopolamine-treated rats. Behavioural Brain Research. 241: 206-13. PMID 23261875 DOI: 10.1016/J.Bbr.2012.12.016 |
0.73 |
|
| 2013 |
Namjoshi OA, Wang ZJ, Rallapalli SK, Johnson EM, Johnson YT, Ng H, Ramerstorfer J, Varagic Z, Sieghart W, Majumder S, Roth BL, Rowlett JK, Cook JM. Search for α3β₂/₃γ2 subtype selective ligands that are stable on human liver microsomes. Bioorganic & Medicinal Chemistry. 21: 93-101. PMID 23218469 DOI: 10.1016/J.Bmc.2012.10.057 |
0.795 |
|
| 2013 |
Divljaković J, Milić M, Namjoshi OA, Tiruveedhula VV, Timić T, Cook JM, Savić MM. βCCT, an antagonist selective for α(1)GABA(A) receptors, reverses diazepam withdrawal-induced anxiety in rats. Brain Research Bulletin. 91: 1-7. PMID 23149168 DOI: 10.1016/J.Brainresbull.2012.10.011 |
0.345 |
|
| 2013 |
Rüedi-Bettschen D, Rowlett JK, Rallapalli S, Clayton T, Cook JM, Platt DM. Modulation of α5 subunit-containing GABAA receptors alters alcohol drinking by rhesus monkeys. Alcoholism, Clinical and Experimental Research. 37: 624-34. PMID 23126673 DOI: 10.1111/Acer.12018 |
0.72 |
|
| 2013 |
Joksimović S, Divljaković J, Van Linn ML, Varagic Z, Brajković G, Milinković MM, Yin W, Timić T, Sieghart W, Cook JM, Savić MM. Benzodiazepine-induced spatial learning deficits in rats are regulated by the degree of modulation of α1 GABA(A) receptors. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 390-9. PMID 22633616 DOI: 10.1016/J.Euroneuro.2012.05.003 |
0.788 |
|
| 2013 |
Soto PL, Ator NA, Rallapalli SK, Biawat P, Clayton T, Cook JM, Weed MR. Erratum: Allosteric Modulation of GABAA Receptor Subtypes: Effects on Visual Recognition and Visuospatial Working Memory in Rhesus Monkeys Neuropsychopharmacology. 38: 2553-2553. DOI: 10.1038/Npp.2013.162 |
0.704 |
|
| 2013 |
Timic T, Joksimovic S, Obradovic A, Poe M, Biawat P, Ramerstorfer J, Roth B, Sieghart W, Cook J, Savic M. P.1.h.029 MK-801-induced hyperlocomotion in rats is affected by modulation of α5-containing GABAA receptors European Neuropsychopharmacology. 23: S259-S260. DOI: 10.1016/S0924-977X(13)70405-X |
0.668 |
|
| 2012 |
Edwankar CR, Edwankar RV, Deschamps JR, Cook JM. Nature-inspired stereospecific total synthesis of P-(+)-dispegatrine and four other monomeric sarpagine indole alkaloids. Angewandte Chemie (International Ed. in English). 51: 11762-5. PMID 23073985 DOI: 10.1002/Anie.201206015 |
0.788 |
|
| 2012 |
Vinkers CH, van Oorschot R, Nielsen EØ, Cook JM, Hansen HH, Groenink L, Olivier B, Mirza NR. GABA(A) receptor α subunits differentially contribute to diazepam tolerance after chronic treatment. Plos One. 7: e43054. PMID 22912786 DOI: 10.1371/Journal.Pone.0043054 |
0.346 |
|
| 2012 |
Milić M, Divljaković J, Rallapalli S, van Linn ML, Timić T, Cook JM, Savić MM. The role of α1 and α5 subunit-containing GABAA receptors in motor impairment induced by benzodiazepines in rats. Behavioural Pharmacology. 23: 191-7. PMID 22327019 DOI: 10.1097/Fbp.0B013E3283512C85 |
0.793 |
|
| 2012 |
Edwankar RV, Edwankar CR, Namjoshi OA, Deschamps JR, Cook JM. Brønsted acid mediated cyclization of enaminones. Rapid and efficient access to the tetracyclic framework of the Strychnos alkaloids. Journal of Natural Products. 75: 181-8. PMID 22257244 DOI: 10.1021/Np200759H |
0.787 |
|
| 2012 |
Kabir MS, Namjoshi OA, Verma R, Lorenz M, Tiruveedhula VV, Monte A, Bertz SH, Schwabacher AW, Cook JM. Base-mediated stereospecific synthesis of aryloxy and amino substituted ethyl acrylates. The Journal of Organic Chemistry. 77: 300-10. PMID 22073965 DOI: 10.1021/Jo201948E |
0.644 |
|
| 2012 |
Gallos G, Yim P, Chang S, Zhang Y, Xu D, Cook JM, Gerthoffer WT, Emala CW. Targeting the restricted α-subunit repertoire of airway smooth muscle GABAA receptors augments airway smooth muscle relaxation. American Journal of Physiology. Lung Cellular and Molecular Physiology. 302: L248-56. PMID 21949156 DOI: 10.1152/Ajplung.00131.2011 |
0.322 |
|
| 2012 |
Vinkers CH, Hendriksen H, van Oorschot R, Cook JM, Rallipalli S, Huang S, Millan MJ, Olivier B, Groenink L. Lifelong CRF overproduction is associated with altered gene expression and sensitivity of discrete GABA(A) and mGlu receptor subtypes. Psychopharmacology. 219: 897-908. PMID 21833506 DOI: 10.1007/S00213-011-2423-0 |
0.721 |
|
| 2012 |
Schwan WR, Kabir MS, Kallaus M, Krueger S, Monte A, Cook JM. Synthesis and minimum inhibitory concentrations of SK-03-92 against Staphylococcus aureus and other gram-positive bacteria. Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy. 18: 124-6. PMID 21739106 DOI: 10.1007/S10156-011-0273-7 |
0.589 |
|
| 2011 |
Edwankar RV, Edwankar CR, Deschamps J, Cook JM. Regiospecific, enantiospecific total synthesis of C-19 methyl substituted sarpagine alkaloids dihydroperaksine-17-al and dihydroperaksine. Organic Letters. 13: 5216-9. PMID 21877687 DOI: 10.1021/Ol202101P |
0.789 |
|
| 2011 |
Iyer SV, Benavides RA, Chandra D, Cook JM, Rallapalli S, June HL, Homanics GE. α4-Containing GABA(A) Receptors are Required for Antagonism of Ethanol-Induced Motor Incoordination and Hypnosis by the Imidazobenzodiazepine Ro15-4513. Frontiers in Pharmacology. 2: 18. PMID 21779248 DOI: 10.3389/Fphar.2011.00018 |
0.702 |
|
| 2011 |
Namjoshi OA, Gryboski A, Fonseca GO, Van Linn ML, Wang ZJ, Deschamps JR, Cook JM. Development of a two-step route to 3-PBC and βCCt, two agents active against alcohol self-administration in rodent and primate models. The Journal of Organic Chemistry. 76: 4721-7. PMID 21495660 DOI: 10.1021/Jo200425M |
0.758 |
|
| 2011 |
Di Lio A, Benke D, Besson M, Desmeules J, Daali Y, Wang ZJ, Edwankar R, Cook JM, Zeilhofer HU. HZ166, a novel GABAA receptor subtype-selective benzodiazepine site ligand, is antihyperalgesic in mouse models of inflammatory and neuropathic pain. Neuropharmacology. 60: 626-32. PMID 21145329 DOI: 10.1016/J.Neuropharm.2010.11.026 |
0.796 |
|
| 2011 |
Pavel H, Ajeawung N, Faure R, Poirier D, Kamnasaran D, Ajeawung N, Joshi H, Kamnasaran D, Poirier D, Ajeawung N, Kamnasaran D, Lun X, Zemp F, Sun B, Stechishin O, ... ... Cook J, et al. PRECLINICAL EXPERIMENTAL THERAPEUTICS AND PHARMACOLOGY Neuro-Oncology. 13: iii107-iii120. DOI: 10.1093/Neuonc/Nor158 |
0.685 |
|
| 2010 |
Yin W, Majumder S, Clayton T, Petrou S, VanLinn ML, Namjoshi OA, Ma C, Cromer BA, Roth BL, Platt DM, Cook JM. Design, synthesis, and subtype selectivity of 3,6-disubstituted β-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse. Bioorganic & Medicinal Chemistry. 18: 7548-64. PMID 20888240 DOI: 10.1016/J.Bmc.2010.08.049 |
0.782 |
|
| 2010 |
Fischer BD, Licata SC, Edwankar RV, Wang ZJ, Huang S, He X, Yu J, Zhou H, Johnson EM, Cook JM, Furtmüller R, Ramerstorfer J, Sieghart W, Roth BL, Majumder S, et al. Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure. Neuropharmacology. 59: 612-8. PMID 20727364 DOI: 10.1016/J.Neuropharm.2010.08.011 |
0.799 |
|
| 2010 |
Kabir MS, Namjoshi OA, Verma R, Polanowski R, Krueger SM, Sherman D, Rott MA, Schwan WR, Monte A, Cook JM. A new class of potential anti-tuberculosis agents: Synthesis and preliminary evaluation of novel acrylic acid ethyl ester derivatives. Bioorganic & Medicinal Chemistry. 18: 4178-86. PMID 20537903 DOI: 10.1016/J.Bmc.2010.05.016 |
0.638 |
|
| 2010 |
Kabir MS, Lorenz M, Van Linn ML, Namjoshi OA, Ara S, Cook JM. A very active cu-catalytic system for the synthesis of aryl, heteroaryl, and vinyl sulfides. The Journal of Organic Chemistry. 75: 3626-43. PMID 20429581 DOI: 10.1021/Jo1004179 |
0.795 |
|
| 2010 |
Van Linn ML, Cook JM. Mechanistic studies on the cis to trans epimerization of trisubstituted 1,2,3,4-tetrahydro-beta-carbolines. The Journal of Organic Chemistry. 75: 3587-99. PMID 20429580 DOI: 10.1021/Jo1003778 |
0.766 |
|
| 2010 |
Yin W, Kabir MS, Wang Z, Rallapalli SK, Ma J, Cook JM. Enantiospecific total synthesis of the important biogenetic intermediates along the ajmaline pathway, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epivellosimine and macusine A. The Journal of Organic Chemistry. 75: 3339-49. PMID 20392128 DOI: 10.1021/Jo100279W |
0.804 |
|
| 2010 |
Lorenz M, Kabir MS, Cook JM. A two step synthesis of BzR/GABAergic active flavones via a Wacker-related oxidation. Tetrahedron Letters. 51: 1095. PMID 20161661 DOI: 10.1016/J.Tetlet.2009.12.107 |
0.637 |
|
| 2010 |
Savić MM, Kukić JM, Grayer RJ, Milinković MM, Marin PD, Divljaković J, Van Linn M, Cook JM, Petrović SD. Behavioural characterization of four endemic Stachys taxa. Phytotherapy Research : Ptr. 24: 1309-16. PMID 20127664 DOI: 10.1002/Ptr.3106 |
0.759 |
|
| 2010 |
Savić MM, Majumder S, Huang S, Edwankar RV, Furtmüller R, Joksimović S, Clayton T, Ramerstorfer J, Milinković MM, Roth BL, Sieghart W, Cook JM. Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats? Progress in Neuro-Psychopharmacology & Biological Psychiatry. 34: 376-86. PMID 20074611 DOI: 10.1016/J.Pnpbp.2010.01.004 |
0.798 |
|
| 2010 |
Kabir MS, Lorenz M, Namjoshi OA, Cook JM. First application of an efficient and versatile ligand for copper-catalyzed cross-coupling reactions of vinyl halides with N-heterocycles and phenols. Organic Letters. 12: 464-7. PMID 20039699 DOI: 10.1021/Ol9026446 |
0.637 |
|
| 2010 |
Grant JA, Bonnick T, Gossell-Williams M, Clayton T, Cook JM, Jackson YA. Synthesis, pharmacological studies and molecular modeling of some tetracyclic 1,3-diazepinium chlorides. Bioorganic & Medicinal Chemistry. 18: 909-21. PMID 19962901 DOI: 10.1016/J.Bmc.2009.11.032 |
0.343 |
|
| 2010 |
Licata SC, Platt DM, Rüedi-Bettschen D, Atack JR, Dawson GR, Van Linn ML, Cook JM, Rowlett JK. Discriminative stimulus effects of L-838,417 (7-tert-butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): role of GABA(A) receptor subtypes. Neuropharmacology. 58: 357-64. PMID 19853619 DOI: 10.1016/J.Neuropharm.2009.10.004 |
0.77 |
|
| 2010 |
Lorenz M, van Linn ML, Cook JM. The asymmetric pictet-spengler reaction Current Organic Synthesis. 7: 189-223. DOI: 10.2174/157017910791163011 |
0.752 |
|
| 2010 |
Yang J, Rallapalli SK, Cook JM. The first enantiospecific total synthesis of the 3-oxygenated sarpagine indole alkaloids affinine and 16-epiaffinine, as well as vobasinediol and 16-epivobasinediol Tetrahedron Letters. 51: 815-817. DOI: 10.1016/J.Tetlet.2009.12.002 |
0.721 |
|
| 2010 |
Ma C, Yu S, He X, Liu X, Cook JM. ChemInform Abstract: Efficient Asymmetric Synthesis of Important Tryptophan Analogues for Biological Research via the Schoellkopf Chiral Auxiliary. Cheminform. 31: no-no. DOI: 10.1002/chin.200030181 |
0.691 |
|
| 2010 |
Ma C, He X, Liu X, Yu S, Zhao S, Cook JM. ChemInform Abstract: Effect of the Leaving Group on the Alkylation Diastereoselectivity of the Schoellkopf Chiral Auxiliary. Cheminform. 30: no-no. DOI: 10.1002/chin.199929029 |
0.68 |
|
| 2010 |
Ma C, Liu X, Yu S, Zhao S, Cook JM. ChemInform Abstract: Concise Synthesis of Optically Active Ring-A Substituted Tryptophans. Cheminform. 30: no-no. DOI: 10.1002/chin.199917221 |
0.69 |
|
| 2010 |
COX ED, LI J, HAMAKER LK, YU P, COOK JM. ChemInform Abstract: Evidence for C(1)-N(2) Bond Scission in the Isomerization of cis-1,3- Disubstituted Nb-Benzyl-1,2,3,4-tetrahydro-β-carbolines into Their trans Diastereomers under Acidic Conditions. Cheminform. 28: no-no. DOI: 10.1002/chin.199710126 |
0.781 |
|
| 2010 |
COX ED, HAGEN TJ, MCKERNAN RM, COOK JM. ChemInform Abstract: Bz1 Receptor Subtype Specific Ligands. Synthesis and Biological Properties of βCCt, a Bz1 Receptor Subtype Specific Antagonist. Cheminform. 27: no-no. DOI: 10.1002/chin.199621165 |
0.635 |
|
| 2010 |
PETERSON AC, LA LOGGIA AJ, HAMAKER LK, AREND RA, FISETTE PL, OZAKI Y, WILL JA, BROWN RR, COOK JM. ChemInform Abstract: Evaluation of Substituted β-Carbolines as Noncompetitive Indolamine 2,3-Dioxygenase Inhibitors. Cheminform. 25: no-no. DOI: 10.1002/chin.199435294 |
0.778 |
|
| 2010 |
MARTIN MJ, DORN LJ, COOK JM. ChemInform Abstract: Novel Pyridodiindoles, Azadiindoles, and Indolopyridoimidazoles via the Fischer Indole Cyclization Cheminform. 24: no-no. DOI: 10.1002/chin.199312322 |
0.563 |
|
| 2010 |
CZERWINSKI KM, DENG L, COOK JM. ChemInform Abstract: Mechanism Driven trans-Stereospecificity in the Pictet-Spengler Reaction. Stereospecific Formation of trans-1,2,3-Trisubstituted Tetrahydro-β-carbolines by Condensation of Nβ- Diphenylmethyltryptophan Isopropyl Esters with Aldehydes. Cheminform. 24: no-no. DOI: 10.1002/chin.199301197 |
0.793 |
|
| 2010 |
TRUDELL ML, SOERENS D, WEBER RW, HUTCHINS L, GRUBISHA D, BENNETT D, COOK JM. ChemInform Abstract: Pictet-Spengler Reactions in Aprotic Media. The Total Synthesis of (.+-.) Suaveoline. Cheminform. 23: no-no. DOI: 10.1002/chin.199226273 |
0.548 |
|
| 2010 |
SZKARADZINSKA MB, ROSZAK AW, TRUDELL ML, COOK JM, CODDING PW. ChemInform Abstract: Structure of 2-Chloro-7,12-dihydropyrido(3,2-b:5,4-b′)diindole Cheminform. 23: no-no. DOI: 10.1002/chin.199221056 |
0.494 |
|
| 2010 |
DENG L, CZERWINSKI K, COOK JM. ChemInform Abstract: Stereospecificity in the Pictet-Spengler Reaction. Kinetic vs Thermodynamic Control. Cheminform. 22: no-no. DOI: 10.1002/chin.199148171 |
0.776 |
|
| 2010 |
ALLEN MS, TAN Y, TRUDELL ML, NARAYANAN K, SCHINDLER LR, MARTIN MJ, SCHULTZ C, HAGEN TJ, KOEHLER KF, CODDING PW, SKOLNICK P, COOK JM. ChemInform Abstract: Synthetic and Computer-Assisted Analyses of the Pharmacophore for the Benzodiazepine Receptor Inverse Agonist Site. Cheminform. 22: no-no. DOI: 10.1002/chin.199108209 |
0.751 |
|
| 2009 |
Yang J, Teng Y, Ara S, Rallapalli S, Cook JM. An Improved Process for the Synthesis of 4H-Imidazo[1,5-a][1,4]benzodiazepines. Synthesis. 40: nihpa145687. PMID 19936036 DOI: 10.1055/S-0028-1083358 |
0.709 |
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| 2009 |
Edwankar CR, Edwankar RV, Namjoshi OA, Rallapalli SK, Yang J, Cook JM. Recent progress in the total synthesis of indole alkaloids. Current Opinion in Drug Discovery & Development. 12: 752-71. PMID 19894188 |
0.803 |
|
| 2009 |
Rivas FM, Stables JP, Murphree L, Edwankar RV, Edwankar CR, Huang S, Jain HD, Zhou H, Majumder S, Sankar S, Roth BL, Ramerstorfer J, Furtmüller R, Sieghart W, Cook JM. Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models. Journal of Medicinal Chemistry. 52: 1795-8. PMID 19275170 DOI: 10.1021/Jm801652D |
0.792 |
|
| 2009 |
Kumpaty HJ, Van Linn ML, Kabir MS, Försterling FH, Deschamps JR, Cook JM. Study of the cis to trans isomerization of 1-phenyl-2,3-disubstituted tetrahydro-beta-carbolines at C(1). Evidence for the carbocation-mediated mechanism. The Journal of Organic Chemistry. 74: 2771-9. PMID 19275130 DOI: 10.1021/Jo8028168 |
0.793 |
|
| 2009 |
Savić MM, Milinković MM, Rallapalli S, Clayton T, Joksimović S, Van Linn M, Cook JM. The differential role of alpha1- and alpha5-containing GABA(A) receptors in mediating diazepam effects on spontaneous locomotor activity and water-maze learning and memory in rats. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 12: 1179-93. PMID 19265570 DOI: 10.1017/S1461145709000108 |
0.793 |
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| 2009 |
Vinkers CH, Klanker M, Groenink L, Korte SM, Cook JM, Van Linn ML, Hopkins SC, Olivier B. Dissociating anxiolytic and sedative effects of GABAAergic drugs using temperature and locomotor responses to acute stress. Psychopharmacology. 204: 299-311. PMID 19169673 DOI: 10.1007/S00213-009-1460-4 |
0.776 |
|
| 2009 |
Takahashi A, Yap JJ, Bohager DZ, Faccidomo S, Clayton T, Cook JM, Miczek KA. Glutamatergic and GABAergic modulations of ultrasonic vocalizations during maternal separation distress in mouse pups. Psychopharmacology. 204: 61-71. PMID 19099296 DOI: 10.1007/S00213-008-1437-8 |
0.352 |
|
| 2009 |
Ma J, Yin W, Zhou H, Liao X, Cook JM. General approach to the total synthesis of 9-methoxy-substituted indole alkaloids: synthesis of mitragynine, as well as 9-methoxygeissoschizol and 9-methoxy-N(b)-methylgeissoschizol. The Journal of Organic Chemistry. 74: 264-73. PMID 19046119 DOI: 10.1021/Jo801839T |
0.68 |
|
| 2009 |
Licata SC, Platt DM, Cook JM, Van Linn ML, Rowlett JK. Contribution of alpha1 subunit-containing gamma-aminobutyric acidA (GABAA) receptors to motor-impairing effects of benzodiazepines in squirrel monkeys. Psychopharmacology. 203: 539-46. PMID 19031072 DOI: 10.1007/S00213-008-1401-7 |
0.769 |
|
| 2009 |
Yang J, Teng Y, Ara S, Rallapalli S, Cook JM. An improved process for the synthesis of 4H-imidazo[1,5-a][1,4] benzodiazepines Synthesis. 1036-1040. DOI: 10.1055/s-0028-1083358 |
0.686 |
|
| 2008 |
Shahjahan Kabir M, Engelbrecht K, Polanowski R, Krueger SM, Ignasiak R, Rott M, Schwan WR, Stemper ME, Reed KD, Sherman D, Cook JM, Monte A. New classes of Gram-positive selective antibacterials: inhibitors of MRSA and surrogates of the causative agents of anthrax and tuberculosis. Bioorganic & Medicinal Chemistry Letters. 18: 5745-9. PMID 18849164 DOI: 10.1016/J.Bmcl.2008.09.085 |
0.3 |
|
| 2008 |
Han D, Holger Försterling F, Li X, Deschamps JR, Parrish D, Cao H, Rallapalli S, Clayton T, Teng Y, Majumder S, Sankar S, Roth BL, Sieghart W, Furtmuller R, Rowlett JK, ... ... Cook JM, et al. A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis. Bioorganic & Medicinal Chemistry. 16: 8853-62. PMID 18790643 DOI: 10.1016/J.Bmc.2008.08.072 |
0.76 |
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| 2008 |
Yang J, Wearing XZ, Le Quesne PW, Deschamps JR, Cook JM. Enantiospecific synthesis of (+)-alstonisine via a stereospecific osmylation process. Journal of Natural Products. 71: 1431-40. PMID 18611051 DOI: 10.1021/Np800269K |
0.331 |
|
| 2008 |
Kabir MS, Van Linn ML, Monte A, Cook JM. Stereo- and regiospecific cu-catalyzed cross-coupling reaction of vinyl iodides and thiols: a very mild and general route for the synthesis of vinyl sulfides. Organic Letters. 10: 3363-6. PMID 18611035 DOI: 10.1021/Ol801149N |
0.788 |
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| 2008 |
Harris D, Clayton T, Cook J, Sahbaie P, Halliwell RF, Furtmüller R, Huck S, Sieghart W, DeLorey TM. Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. Journal of Medicinal Chemistry. 51: 3788-803. PMID 18537233 DOI: 10.1021/Jm701433B |
0.348 |
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| 2008 |
Savić MM, Clayton T, Furtmüller R, Gavrilović I, Samardzić J, Savić S, Huck S, Sieghart W, Cook JM. PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats. Brain Research. 1208: 150-9. PMID 18394590 DOI: 10.1016/J.Brainres.2008.02.020 |
0.352 |
|
| 2008 |
Jain HD, Zhang C, Zhou S, Zhou H, Ma J, Liu X, Liao X, Deveau AM, Dieckhaus CM, Johnson MA, Smith KS, Macdonald TL, Kakeya H, Osada H, Cook JM. Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein. Bioorganic & Medicinal Chemistry. 16: 4626-51. PMID 18321710 DOI: 10.1016/J.Bmc.2008.02.050 |
0.786 |
|
| 2008 |
Savić MM, Huang S, Furtmüller R, Clayton T, Huck S, Obradović DI, Ugresić ND, Sieghart W, Bokonjić DR, Cook JM. Are GABAA receptors containing alpha5 subunits contributing to the sedative properties of benzodiazepine site agonists? Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 332-9. PMID 17392731 DOI: 10.1038/Sj.Npp.1301403 |
0.719 |
|
| 2008 |
Edwankar CR, Edwankar RV, Rallapalli S, Cook JM. General approach to the total synthesis of macroline-related sarpagine and ajmaline alkaloids Natural Product Communications. 3: 1839-1870. DOI: 10.1177/1934578X0800301114 |
0.781 |
|
| 2007 |
Clayton T, Chen JL, Ernst M, Richter L, Cromer BA, Morton CJ, Ng H, Kaczorowski CC, Helmstetter FJ, Furtmüller R, Ecker G, Parker MW, Sieghart W, Cook JM. An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric acid(a) receptors: correlation with comparative models. Current Medicinal Chemistry. 14: 2755-75. PMID 18045122 DOI: 10.2174/092986707782360097 |
0.352 |
|
| 2007 |
Ma J, Yin W, Zhou H, Cook JM. Total synthesis of the opioid agonistic indole alkaloid mitragynine and the first total syntheses of 9-methoxygeissoschizol and 9-methoxy-Nb-methylgeissoschizol. Organic Letters. 9: 3491-4. PMID 17685530 DOI: 10.1021/Ol071220L |
0.574 |
|
| 2007 |
Liao X, Huang S, Zhou H, Parrish D, Cook JM. Cascade approach toward the core structure of neosarpagine. Organic Letters. 9: 1469-71. PMID 17358071 DOI: 10.1021/Ol070148O |
0.742 |
|
| 2007 |
Han D, Försterling FH, Deschamps JR, Parrish D, Liu X, Yin W, Huang S, Cook JM. Conformational analysis of the cis- and trans-adducts of the Pictet - Spengler reaction. Evidence for the structural basis for the C(1) - N(2) scission process in the cis- to trans-isomerization. Journal of Natural Products. 70: 75-82. PMID 17253853 DOI: 10.1021/Np060391G |
0.779 |
|
| 2007 |
Yin W, Ma J, Rivas FM, Cook JM. First enantiospecific total synthesis of the important biogenetic intermediates, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epi-vellosimine and macusine A. Organic Letters. 9: 295-8. PMID 17217288 DOI: 10.1021/Ol062762Q |
0.577 |
|
| 2007 |
June HL, Foster KL, Eiler WJ, Goergen J, Cook JB, Johnson N, Mensah-Zoe B, Simmons JO, June HL, Yin W, Cook JM, Homanics GE. Dopamine and benzodiazepine-dependent mechanisms regulate the EtOH-enhanced locomotor stimulation in the GABAA alpha1 subunit null mutant mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 137-52. PMID 16710315 DOI: 10.1038/Sj.Npp.1301097 |
0.491 |
|
| 2007 |
Kabir MS, Monte A, Cook JM. An efficient palladium-catalyzed Negishi cross-coupling reaction with arylvinyl iodides: facile regioselective synthesis of E-stilbenes and their analogues Tetrahedron Letters. 48: 7269-7273. DOI: 10.1016/J.Tetlet.2007.08.047 |
0.632 |
|
| 2007 |
Yin W, Ma J, Rivas FM, Cook JM. First Enantiospecific Total Synthesis of the Important Biogenetic Intermediates, (+)-Polyneuridine(Ia) and (+)-Polyneuridine Aldehyde(IIa), as well as 16-Epi-vellosimine (IIb) and Macusine A (Ib). Cheminform. 38. DOI: 10.1002/chin.200721177 |
0.521 |
|
| 2006 |
Liao X, Zhou H, Yu J, Cook JM. An improved total synthesis of (+)-macroline and alstonerine as well as the formal total synthesis of (-)-talcarpine and (-)-anhydromacrosalhine-methine. The Journal of Organic Chemistry. 71: 8884-90. PMID 17081019 DOI: 10.1021/Jo061652U |
0.5 |
|
| 2006 |
Turner JG, Gump JL, Zhang C, Cook JM, Marchion D, Hazlehurst L, Munster P, Schell MJ, Dalton WS, Sullivan DM. ABCG2 expression, function, and promoter methylation in human multiple myeloma. Blood. 108: 3881-9. PMID 16917002 DOI: 10.1182/Blood-2005-10-009084 |
0.611 |
|
| 2006 |
Duke AN, Platt DM, Cook JM, Huang S, Yin W, Mattingly BA, Rowlett JK. Enhanced sucrose pellet consumption induced by benzodiazepine-type drugs in squirrel monkeys: role of GABAA receptor subtypes. Psychopharmacology. 187: 321-30. PMID 16783540 DOI: 10.1007/S00213-006-0431-2 |
0.756 |
|
| 2006 |
Savić MM, Obradović DI, Ugresić ND, Cook JM, Yin W, Van Linn M, Bokonjić DR. Benzodiazepine site inverse agonists and locomotor activity in rats: bimodal and biphasic influence. Pharmacology, Biochemistry, and Behavior. 84: 35-42. PMID 16725185 DOI: 10.1016/J.Pbb.2006.04.001 |
0.787 |
|
| 2006 |
Zhou H, Liao X, Yin W, Ma J, Cook JM. General approach for the synthesis of 12-methoxy-substituted sarpagine indole alkaloids including (-)-12-methoxy-N(b)-methylvoachalotine, (+)-12-methoxy-N(a)-methylvellosimine, (+)-12-methoxyaffinisine, and (-)-fuchsiaefoline. The Journal of Organic Chemistry. 71: 251-9. PMID 16388644 DOI: 10.1021/Jo052081T |
0.665 |
|
| 2005 |
Cook JB, Foster KL, Eiler WJ, McKay PF, Woods J, Harvey SC, Garcia M, Grey C, McCane S, Mason D, Cummings R, Li X, Cook JM, June HL. Selective GABAA alpha5 benzodiazepine inverse agonist antagonizes the neurobehavioral actions of alcohol. Alcoholism, Clinical and Experimental Research. 29: 1390-401. PMID 16131846 DOI: 10.1097/01.Alc.0000175073.94575.86 |
0.403 |
|
| 2005 |
Liao X, Zhou H, Wearing XZ, Ma J, Cook JM. The first regiospecific, enantiospecific total synthesis of 6-oxoalstophylline and an improved total synthesis of alstonerine and alstophylline as well as the bisindole alkaloid macralstonine. Organic Letters. 7: 3501-4. PMID 16048327 DOI: 10.1021/Ol051208Y |
0.53 |
|
| 2005 |
Yu J, Wearing XZ, Cook JM. A general strategy for the synthesis of vincamajine-related indole alkaloids: stereocontrolled total synthesis of (+)-dehydrovoachalotine, (-)-vincamajinine, and (-)-11-methoxy-17-epivincamajine as well as the related quebrachidine diol, vincamajine diol, and vincarinol. The Journal of Organic Chemistry. 70: 3963-79. PMID 15876085 DOI: 10.1021/Jo040282B |
0.381 |
|
| 2005 |
Savić MM, Obradović DI, Ugresić ND, Cook JM, Sarma PV, Bokonjić DR. Bidirectional effects of benzodiazepine binding site ligands on active avoidance acquisition and retention: differential antagonism by flumazenil and beta-CCt. Psychopharmacology. 180: 455-65. PMID 15719222 DOI: 10.1007/S00213-005-2170-1 |
0.338 |
|
| 2005 |
Savić MM, Obradović DI, Ugresić ND, Cook JM, Yin W, Bokonjić DR. Bidirectional effects of benzodiazepine binding site ligands in the passive avoidance task: differential antagonism by flumazenil and beta-CCt. Behavioural Brain Research. 158: 293-300. PMID 15698896 DOI: 10.1016/J.Bbr.2004.09.011 |
0.526 |
|
| 2005 |
Licata SC, Platt DM, Cook JM, Sarma PV, Griebel G, Rowlett JK. Contribution of GABAA receptor subtypes to the anxiolytic-like, motor, and discriminative stimulus effects of benzodiazepines: studies with the functionally selective ligand SL651498 [6-fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihydro-1H-pyridol[3,4-b]indol-1-one]. The Journal of Pharmacology and Experimental Therapeutics. 313: 1118-25. PMID 15687371 DOI: 10.1124/Jpet.104.081612 |
0.36 |
|
| 2005 |
Cao H, Van Ornum SG, Deschamps J, Flippen-Anderson J, Laib F, Cook JM. Synthesis of dicyclopenta[a,e]pentalenes via a molybdenum carbonyl mediated tandem allenic Pauson-Khand reaction and the X-ray crystal structure of a planar dicyclopenta[a,e]pentalene. Journal of the American Chemical Society. 127: 933-43. PMID 15656632 DOI: 10.1021/Ja040120X |
0.418 |
|
| 2005 |
Platt DM, Duggan A, Spealman RD, Cook JM, Li X, Yin W, Rowlett JK. Contribution of alpha 1GABAA and alpha 5GABAA receptor subtypes to the discriminative stimulus effects of ethanol in squirrel monkeys. The Journal of Pharmacology and Experimental Therapeutics. 313: 658-67. PMID 15650112 DOI: 10.1124/Jpet.104.080275 |
0.563 |
|
| 2005 |
Rowlett JK, Cook JM, Duke AN, Platt DM. Selective antagonism of GABAA receptor subtypes: an in vivo approach to exploring the therapeutic and side effects of benzodiazepine-type drugs. Cns Spectrums. 10: 40-8. PMID 15618946 DOI: 10.1017/S1092852900009895 |
0.331 |
|
| 2005 |
Gourley SL, Debold JF, Yin W, Cook J, Miczek KA. Benzodiazepines and heightened aggressive behavior in rats: reduction by GABA(A)/alpha(1) receptor antagonists. Psychopharmacology. 178: 232-40. PMID 15316711 DOI: 10.1007/S00213-004-1987-3 |
0.528 |
|
| 2005 |
Yin W, Sarma PVVS, Ma J, Han D, Chen JL, Cook JM. Synthesis of bivalent ligands of β-carboline-3-carboxylates via a palladium-catalyzed homocoupling process Tetrahedron Letters. 46: 6363-6368. DOI: 10.1016/J.Tetlet.2005.07.022 |
0.56 |
|
| 2005 |
Zhou H, Han D, Liao X, Cook JM. First regiospecific, enantiospecific total synthesis of gardnerine and gardnutine Tetrahedron Letters. 46: 4219-4224. DOI: 10.1016/J.Tetlet.2005.04.051 |
0.515 |
|
| 2004 |
Savić MM, Obradović DI, Ugresić ND, Cook JM, Yin W, Bokonjić DR. Bidirectional effects of benzodiazepine binding site ligands in the elevated plus-maze: differential antagonism by flumazenil and beta-CCt. Pharmacology, Biochemistry, and Behavior. 79: 279-90. PMID 15501303 DOI: 10.1016/J.Pbb.2004.07.013 |
0.521 |
|
| 2004 |
Han D, Försterling FH, Li X, Deschamps JR, Cao H, Cook JM. Determination of the stable conformation of GABA(A)-benzodiazepine receptor bivalent ligands by low temperature NMR and X-ray analysis. Bioorganic & Medicinal Chemistry Letters. 14: 1465-9. PMID 15006383 DOI: 10.1016/J.Bmcl.2004.01.018 |
0.504 |
|
| 2004 |
Yu J, Wearing XZ, Cook JM. Stereocontrolled total synthesis of (-)-vincamajinine and (-)-11-methoxy-17-epivincamajine. Journal of the American Chemical Society. 126: 1358-9. PMID 14759191 DOI: 10.1021/Ja039798N |
0.346 |
|
| 2004 |
Zhou H, Liao X, Cook JM. Regiospecific, enantiospecific total synthesis of the 12-alkoxy-substituted indole alkaloids, (+)-12-methoxy-Na-methylvellosimine, (+)-12-methoxyaffinisine, and (-)-fuchsiaefoline. Organic Letters. 6: 249-52. PMID 14723540 DOI: 10.1021/Ol0362212 |
0.529 |
|
| 2004 |
McKay PF, Foster KL, Mason D, Cummings R, Garcia M, Williams LS, Grey C, McCane S, He X, Cook JM, June HL. A high affinity ligand for GABAA-receptor containing alpha5 subunit antagonizes ethanol's neurobehavioral effects in Long-Evans rats. Psychopharmacology. 172: 455-62. PMID 14666398 DOI: 10.1007/S00213-003-1671-Z |
0.51 |
|
| 2004 |
Foster KL, McKay PF, Seyoum R, Milbourne D, Yin W, Sarma PV, Cook JM, June HL. GABA(A) and opioid receptors of the central nucleus of the amygdala selectively regulate ethanol-maintained behaviors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 269-84. PMID 14666116 DOI: 10.1038/Sj.Npp.1300306 |
0.529 |
|
| 2004 |
de Almeida RM, Rowlett JK, Cook JM, Yin W, Miczek KA. GABAA/alpha1 receptor agonists and antagonists: effects on species-typical and heightened aggressive behavior after alcohol self-administration in mice. Psychopharmacology. 172: 255-63. PMID 14647970 DOI: 10.1007/S00213-003-1661-1 |
0.513 |
|
| 2004 |
Li X, Yin W, Sarma PVVS, Zhou H, Jun Ma, Cook JM. Synthesis of optically active ring-A substituted tryptophans as IDO inhibitors Tetrahedron Letters. 45: 8569-8573. DOI: 10.1016/J.Tetlet.2004.09.113 |
0.556 |
|
| 2004 |
Yu J, Wearing XZ, Cook JM. The First Enantiospecific Total Synthesis of a C-Quaternary Voachalotine Alkaloid, (+)-Dehydrovoachalotine. Cheminform. 35. DOI: 10.1016/J.Tetlet.2004.03.096 |
0.338 |
|
| 2004 |
Li X, Yu J, Atack JR, Cook JM. Development of selective ligands for benzodiazepine receptor subtypes by manipulating the substituents at positions 3- and 7- of optically active BzR ligands Medicinal Chemistry Research. 13: 259-281. DOI: 10.1007/S00044-004-0033-7 |
0.399 |
|
| 2003 |
Li X, Cao H, Zhang C, Furtmueller R, Fuchs K, Huck S, Sieghart W, Deschamps J, Cook JM. Synthesis, in vitro affinity, and efficacy of a bis 8-ethynyl-4H-imidazo[1,5a]- [1,4]benzodiazepine analogue, the first bivalent alpha5 subtype selective BzR/GABA(A) antagonist. Journal of Medicinal Chemistry. 46: 5567-70. PMID 14667209 DOI: 10.1021/Jm034164C |
0.723 |
|
| 2003 |
Yu J, Wang T, Liu X, Deschamps J, Flippen-Anderson J, Liao X, Cook JM. General approach for the synthesis of sarpagine indole alkaloids. Enantiospecific total synthesis of (+)-vellosimine, (+)-normacusine B, (-)-alkaloid Q3, (-)-panarine, (+)-Na-methylvellosimine, and (+)-Na-methyl-16-epipericyclivine. The Journal of Organic Chemistry. 68: 7565-81. PMID 14510528 DOI: 10.1021/Jo030006H |
0.722 |
|
| 2003 |
June HL, Foster KL, McKay PF, Seyoum R, Woods JE, Harvey SC, Eiler WJ, Grey C, Carroll MR, McCane S, Jones CM, Yin W, Mason D, Cummings R, Garcia M, ... ... Cook JM, et al. The reinforcing properties of alcohol are mediated by GABA(A1) receptors in the ventral pallidum. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 2124-37. PMID 12968126 DOI: 10.1038/Sj.Npp.1300239 |
0.76 |
|
| 2003 |
Zhao S, Liao X, Wang T, Flippen-Anderson J, Cook JM. The enantiospecific, stereospecific total synthesis of the ring-A oxygenated sarpagine indole alkaloids (+)-majvinine, (+)-10-methoxyaffinisine, and (+)-N(a)-methylsarpagine, as well as the total synthesis of the alstonia bisindole alkaloid macralstonidine. The Journal of Organic Chemistry. 68: 6279-95. PMID 12895062 DOI: 10.1021/Jo030055U |
0.67 |
|
| 2003 |
Yu J, Wang T, Wearing XZ, Ma J, Cook JM. Enantiospecific total synthesis of (-)-(E)16-epiaffinisine, (+)-(E)16-epinormacusine B, and (+)-dehydro-16-epiaffinisine as well as the stereocontrolled total synthesis of alkaloid G. The Journal of Organic Chemistry. 68: 5852-9. PMID 12868917 DOI: 10.1021/Jo030116O |
0.435 |
|
| 2003 |
Cao H, Flippen-Anderson J, Cook JM. The synthesis of a dicyclopenta[a,e]pentalene via a molybdenum hexacarbonyl-mediated tandem allenic Pauson-Khand reaction. Journal of the American Chemical Society. 125: 3230-1. PMID 12630875 DOI: 10.1021/Ja021159+ |
0.442 |
|
| 2003 |
Rowlett JK, Spealman RD, Lelas S, Cook JM, Yin W. Discriminative stimulus effects of zolpidem in squirrel monkeys: role of GABA(A)/alpha1 receptors. Psychopharmacology. 165: 209-15. PMID 12420154 DOI: 10.1007/S00213-002-1275-Z |
0.529 |
|
| 2003 |
Cao H, Mundla SR, Cook JM. Studies on the Rh and Ir mediated tandem Pauson-Khand reaction. A new entry into the dicyclopenta[a,d]cyclooctene ring system Tetrahedron Letters. 44: 6165-6168. DOI: 10.1016/S0040-4039(03)01418-7 |
0.446 |
|
| 2003 |
Yu J, Wearing XZ, Cook JM. General Approach for the Total Synthesis of the Sarpagine Related Indole Alkaloids (+)-Na-Methyl-16-epipericyclivine, (-)-Alkaloid Q3 and (-)-Panarine via the Asymmetric Pictet—Spengler Reaction Cheminform. 34. DOI: 10.1016/S0040-4039(02)02618-7 |
0.321 |
|
| 2003 |
Cao H, Yu J, Wearing XZ, Zhang C, Liu X, Deschamps J, Cook JM. The first enantiospecific synthesis of (-)-koumidine via the intramolecular palladium-catalyzed enolate driven cross coupling reaction. The stereospecific introduction of the 19-(Z) ethylidene side chain Tetrahedron Letters. 44: 8013-8017. DOI: 10.1016/J.Tetlet.2003.08.072 |
0.78 |
|
| 2002 |
Yu J, Liao X, Cook JM. Stereospecific, enantiospecific total synthesis of the sarpagine indole alkaloids (E)16-epiaffinisine, (E)16-epinormacusine B, and dehydro-16-epiaffinisine. Organic Letters. 4: 4681-4. PMID 12489960 DOI: 10.1021/Ol020209C |
0.492 |
|
| 2002 |
Wearing XZ, Cook JM. Enantiospecific, stereospecific total synthesis of the oxindole alkaloid alstonisine. Organic Letters. 4: 4237-40. PMID 12443067 DOI: 10.1021/Ol020170B |
0.318 |
|
| 2002 |
Platt DM, Rowlett JK, Spealman RD, Cook J, Ma C. Selective antagonism of the ataxic effects of zolpidem and triazolam by the GABAA/alpha1-preferring antagonist beta-CCt in squirrel monkeys. Psychopharmacology. 164: 151-9. PMID 12404077 DOI: 10.1007/S00213-002-1189-9 |
0.72 |
|
| 2002 |
Liu X, Deschamp JR, Cook JM. Regiospecific, enantiospecific total synthesis of the alkoxy-substituted indole bases, 16-epi-N(a)-methylgardneral, 11-methoxyaffinisine, and 11-methoxymacroline as well as the indole alkaloids alstophylline and macralstonine. Organic Letters. 4: 3339-42. PMID 12323013 DOI: 10.1021/Ol020101X |
0.676 |
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| 2002 |
Bailey DJ, Tetzlaff JE, Cook JM, He X, Helmstetter FJ. Effects of hippocampal injections of a novel ligand selective for the alpha 5 beta 2 gamma 2 subunits of the GABA/benzodiazepine receptor on Pavlovian conditioning. Neurobiology of Learning and Memory. 78: 1-10. PMID 12071663 DOI: 10.1006/Nlme.2001.4050 |
0.584 |
|
| 2002 |
Lelas S, Rowlett JK, Spealman RD, Cook JM, Ma C, Li X, Yin W. Role of GABAA/benzodiazepine receptors containing alpha 1 and alpha 5 subunits in the discriminative stimulus effects of triazolam in squirrel monkeys. Psychopharmacology. 161: 180-8. PMID 11981598 DOI: 10.1007/S00213-002-1037-Y |
0.772 |
|
| 2002 |
Harvey SC, Foster KL, McKay PF, Carroll MR, Seyoum R, Woods JE, Grey C, Jones CM, McCane S, Cummings R, Mason D, Ma C, Cook JM, June HL. The GABA(A) receptor alpha1 subtype in the ventral pallidum regulates alcohol-seeking behaviors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 3765-75. PMID 11978852 |
0.694 |
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| 2002 |
Zhao S, Smith KS, Deveau AM, Dieckhaus CM, Johnson MA, Macdonald TL, Cook JM. Biological activity of the tryprostatins and their diastereomers on human carcinoma cell lines. Journal of Medicinal Chemistry. 45: 1559-62. PMID 11931609 DOI: 10.1021/Jm0155953 |
0.513 |
|
| 2002 |
Zhao S, Liao X, Cook JM. Enantiospecific, stereospecific total synthesis of (+)-majvinine, (+)-10-methoxyaffinisine, and (+)-N(a)-methylsarpagine as well as the total synthesis of the Alstonia bisindole macralstonidine. Organic Letters. 4: 687-90. PMID 11869102 DOI: 10.1021/Ol010222H |
0.635 |
|
| 2002 |
McMahon LR, Gerak LR, Carter L, Ma C, Cook JM, France CP. Discriminative stimulus effects of benzodiazepine (BZ)(1) receptor-selective ligands in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 300: 505-12. PMID 11805210 DOI: 10.1124/Jpet.300.2.505 |
0.72 |
|
| 2002 |
Vergnes M, Boehrer A, He X, Greney H, Dontenwill M, Cook J, Marescaux C. Differential sensitivity to inverse agonists of GABA(A)/benzodiazepine receptors in rats with genetic absence-epilepsy. Epilepsy Research. 47: 43-53. PMID 11673020 DOI: 10.1016/S0920-1211(01)00292-3 |
0.575 |
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| 2002 |
Harvey SC, Foster KL, McKay PF, Carroll MR, Seyoum R, Woods JE, Grey C, Jones CM, McCane S, Cummings R, Mason D, Ma C, Cook JM, June HL. The GABAAReceptor α1Subtype in the Ventral Pallidum Regulates Alcohol-Seeking Behaviors The Journal of Neuroscience. 22: 3765-3775. DOI: 10.1523/Jneurosci.22-09-03765.2002 |
0.71 |
|
| 2002 |
Liu X, Zhang C, Liao X, Cook JM. Enantiospecific total synthesis of the enantiomer of the indole alkaloid intermediate macroline Tetrahedron Letters. 43: 7373-7377. DOI: 10.1016/S0040-4039(02)01729-X |
0.809 |
|
| 2001 |
Liu X, Cook JM. General approach for the synthesis of sarpagine/macroline indole alkaloids. Enantiospecific total synthesis of the indole alkaloid trinervine. Organic Letters. 3: 4023-6. PMID 11735575 DOI: 10.1021/Ol0101990 |
0.676 |
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| 2001 |
DeLorey TM, Lin RC, McBrady B, He X, Cook JM, Lameh J, Loew GH. Influence of benzodiazepine binding site ligands on fear-conditioned contextual memory. European Journal of Pharmacology. 426: 45-54. PMID 11525770 DOI: 10.1016/S0014-2999(01)01199-2 |
0.528 |
|
| 2001 |
Paronis CA, Cox ED, Cook JM, Bergman J. Different types of GABA(A) receptors may mediate the anticonflict and response rate-decreasing effects of zaleplon, zolpidem, and midazolam in squirrel monkeys. Psychopharmacology. 156: 461-8. PMID 11498724 DOI: 10.1007/S002130100754 |
0.538 |
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| 2001 |
Wang T, Xu Q, Yu P, Liu X, Cook JM. Stereocontrolled total synthesis of alkaloid G via the oxy-anion Cope rearrangement and improved total synthesis of (+)-ajmaline. Organic Letters. 3: 345-8. PMID 11428010 DOI: 10.1021/Ol000331G |
0.662 |
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| 2001 |
Ma C, Liu X, Li X, Flippen-Anderson J, Yu S, Cook JM. Efficient asymmetric synthesis of biologically important tryptophan analogues via a palladium-mediated heteroannulation reaction. The Journal of Organic Chemistry. 66: 4525-42. PMID 11421771 DOI: 10.1021/Jo001679S |
0.801 |
|
| 2001 |
June HL, Harvey SC, Foster KL, McKay PF, Cummings R, Garcia M, Mason D, Grey C, McCane S, Williams LS, Johnson TB, He X, Rock S, Cook JM. GABA(A) receptors containing (alpha)5 subunits in the CA1 and CA3 hippocampal fields regulate ethanol-motivated behaviors: an extended ethanol reward circuitry. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 2166-77. PMID 11245701 DOI: 10.1523/Jneurosci.21-06-02166.2001 |
0.579 |
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| 2000 |
Strakhova MI, Harvey SC, Cook CM, Cook JM, Skolnick P. A single amino acid residue on the alpha(5) subunit (Ile215) is essential for ligand selectivity at alpha(5)beta(3)gamma(2) gamma-aminobutyric acid(A) receptors. Molecular Pharmacology. 58: 1434-40. PMID 11093783 DOI: 10.1124/Mol.58.6.1434 |
0.309 |
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| 2000 |
Harris DL, DeLorey TM, He X, Cook JM, Loew GH. Determinants of recognition of ligands binding to benzodiazepine receptor/GABA(A) receptors initiating sedation. European Journal of Pharmacology. 401: 271-87. PMID 10936485 DOI: 10.1016/S0014-2999(00)00462-3 |
0.584 |
|
| 2000 |
Wang T, Cook JM. General approach for the synthesis of sarpagine/ajmaline indole alkaloids. Stereospecific total synthesis of the sarpagine alkaloid (+)-vellosimine. Organic Letters. 2: 2057-9. PMID 10891229 DOI: 10.1021/Ol000095+ |
0.353 |
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| 2000 |
Yu P, Wang T, Li J, Cook JM. Enantiospecific total synthesis of the sarpagine related indole alkaloids talpinine and talcarpine as well as the improved total synthesis of alstonerine and anhydromacrosalhine-methine via the asymmetric Pictet-Spengler reaction. The Journal of Organic Chemistry. 65: 3173-91. PMID 10814213 DOI: 10.1021/Jo000126E |
0.416 |
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| 2000 |
Huang Q, He X, Ma C, Liu R, Yu S, Dayer CA, Wenger GR, McKernan R, Cook JM. Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. Journal of Medicinal Chemistry. 43: 71-95. PMID 10633039 DOI: 10.1021/Jm990341R |
0.775 |
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| 2000 |
Yu S, Berner OM, Cook JM. General Approach for the Synthesis of Indole Alkaloids via the Asymmetric Pictet−Spengler Reaction: First Enantiospecific Total Synthesis of (−)-Corynantheidine as Well as the Enantiospecific Total Synthesis of (−)-Corynantheidol, (−)-Geissoschizol, and (+)-Geissoschizine Journal of the American Chemical Society. 122: 7827-7828. DOI: 10.1021/Ja0016553 |
0.315 |
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| 2000 |
Liu X, Wang T, Xu Q, Ma C, Cook JM. Enantiospecific total synthesis of the enantiomer of the indole alkaloid affinisine Tetrahedron Letters. 41: 6299-6303. DOI: 10.1016/S0040-4039(00)01061-3 |
0.792 |
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| 2000 |
Cao H, Van Ornum SG, Cook JM. The molybdenum-mediated tandem Pauson–Khand reaction. High yield entry into [5.5.5.5]tetracyclic systems Tetrahedron Letters. 41: 5313-5316. DOI: 10.1016/S0040-4039(00)00847-9 |
0.441 |
|
| 2000 |
Ma C, Yu S, He X, Liu X, Cook JM. Efficient asymmetric synthesis of important tryptophan analogs for biological research via the Schollkopf chiral auxiliary Tetrahedron Letters. 41: 2781-2785. DOI: 10.1016/S0040-4039(00)00263-X |
0.777 |
|
| 1999 |
Huang Q, Cox ED, Gan T, Ma C, Bennett DW, McKernan RM, Cook JM. Studies of molecular pharmacophore/receptor models for GABAA/benzodiazepine receptor subtypes: binding affinities of substituted beta-carbolines at recombinant alpha x beta 3 gamma 2 subtypes and quantitative structure-activity relationship studies via a comparative molecular field analysis. Drug Design and Discovery. 16: 55-76. PMID 10466057 |
0.481 |
|
| 1999 |
Li J, Wang T, Yu P, Peterson A, Weber R, Soerens D, Grubisha D, Bennett D, Cook JM. General approach for the synthesis of ajmaline/sarpagine indole alkaloids: Enantiospecific total synthesis of (+)-ajmaline, alkaloid G, and norsuaveoline via the asymmetric Pictet-Spengler reaction Journal of the American Chemical Society. 121: 6998-7010. DOI: 10.1021/Ja990184L |
0.807 |
|
| 1999 |
Ma C, He X, Liu X, Yu S, Zhao S, Cook JM. Effect of the leaving group on the alkylation diastereoselectivity of the Schollkopf chiral auxiliary Tetrahedron Letters. 40: 2917-2918. DOI: 10.1016/S0040-4039(99)00394-9 |
0.784 |
|
| 1999 |
Bruendl MM, Van Ornum SG, Chan T, Cook JM. Extension of the tandem Pauson-Khand reaction to [5.6.6.5]tetracycles: A unique entry into cis-fused decalins Tetrahedron Letters. 40: 1113-1116. DOI: 10.1016/S0040-4039(98)02635-5 |
0.319 |
|
| 1999 |
Ma C, Liu X, Yu S, Zhao S, Cook JM. Concise synthesis of optically active ring-A substituted tryptophans Tetrahedron Letters. 40: 657-660. DOI: 10.1016/S0040-4039(98)02497-6 |
0.795 |
|
| 1998 |
Huang Q, Liu R, Zhang P, He X, McKernan R, Gan T, Bennett DW, Cook JM. Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via comparative molecular field analysis. Journal of Medicinal Chemistry. 41: 4130-42. PMID 9767648 DOI: 10.1021/Jm980317Y |
0.549 |
|
| 1998 |
Cox ED, Diaz-Arauzo H, Huang Q, Reddy MS, Ma C, Harris B, McKernan R, Skolnick P, Cook JM. Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423) at wild type and recombinant GABAA receptors. Journal of Medicinal Chemistry. 41: 2537-52. PMID 9651158 DOI: 10.1021/Jm970460B |
0.805 |
|
| 1998 |
June HL, Cason CR, Cheatham G, Lui R, Gan T, Cook JM. GABAA-benzodiazepine receptors in the striatum are involved in the sedation produced by a moderate, but not an intoxicating ethanol dose in outbred Wistar rats. Brain Research. 794: 103-18. PMID 9630547 DOI: 10.1016/S0006-8993(98)00222-4 |
0.318 |
|
| 1998 |
June HL, Grey C, Johnson TB, Williams L, McKay P, Rock S, He X, Cook JM. GABAERGIC SUBSTRATES INTHE NUCLEUS ACCUMBENS (NACC) AND DORSAL HIPPOCAMPUS MEDIATE RESPONDING MAINTAINED BY ETHANOL PRESENTATION IN ALCOHOL-PREFERRING RATS Behavioural Pharmacology. 9: S47. DOI: 10.1097/00008877-199808000-00096 |
0.497 |
|
| 1998 |
Yu P, Cook JM. Enantiospecific Total Synthesis of the Sarpagine Related Indole Alkaloids Talpinine and Talcarpine: The Oxyanion−Cope Approach The Journal of Organic Chemistry. 63: 9160-9161. DOI: 10.1021/Jo981815H |
0.301 |
|
| 1998 |
Li J, Cook JM. General Approach to the Synthesis of Sarpagine and Ajmaline Alkaloids. Enantiospecific Total Synthesis of (+)-Ajmaline and Alkaloid G via the Asymmetric Pictet−Spengler Reaction The Journal of Organic Chemistry. 63: 4166-4167. DOI: 10.1021/Jo980476P |
0.333 |
|
| 1998 |
Gan T, Cook JM. Enantiospecific Total Synthesis of (−)-Anhydromacrosalhine-methine and Partial Synthesis of the Antiamoebic Bisindole Alkaloid (−)-Macrocarpamine1 The Journal of Organic Chemistry. 63: 1478-1483. DOI: 10.1021/Jo971570T |
0.322 |
|
| 1998 |
Wang T, Yu P, Li J, Cook JM. The enantiospecific total synthesis of norsuaveoline Tetrahedron Letters. 39: 8009-8012. DOI: 10.1016/S0040-4039(98)01788-2 |
0.395 |
|
| 1998 |
Zhao S, Gan T, Yu P, Cook JM. Total synthesis of tryprostatin A and B as well as their enantiomers Tetrahedron Letters. 39: 7009-7012. DOI: 10.1016/S0040-4039(98)01466-X |
0.499 |
|
| 1997 |
Liu R, Zhang P, Gan T, Cook JM. Regiospecific Bromination of 3-Methylindoles with NBS and Its Application to the Concise Synthesis of Optically Active Unusual Tryptophans Present in Marine Cyclic Peptides(1). The Journal of Organic Chemistry. 62: 7447-7456. PMID 11671863 DOI: 10.1021/Jo971067G |
0.335 |
|
| 1997 |
Cox ED, Hamaker LK, Li J, Yu P, Czerwinski KM, Deng L, Bennett DW, Cook JM, Watson WH, Krawiec M. Enantiospecific Formation of Trans 1,3-Disubstituted Tetrahydro-beta-carbolines by the Pictet-Spengler Reaction and Conversion of Cis Diastereomers into Their Trans Counterparts by Scission of the C-1/N-2 Bond. The Journal of Organic Chemistry. 62: 44-61. PMID 11671363 DOI: 10.1021/Jo951170A |
0.79 |
|
| 1997 |
Greenberg HE, Scharf M, Mendelson W, Cook JM, Cox E, Scharf SM. Effect of beta-carboline-3-carboxoylate-t-butyl ester on ventilatory control. Life Sciences. 60: 485-92. PMID 9042377 DOI: 10.1016/S0024-3205(96)00679-0 |
0.513 |
|
| 1997 |
Van Ornum SG, Li J, Kubiak GG, Cook JM. Steric and electronic effects on the Weiss reaction. Isolation of 1:1 adducts Journal of the Chemical Society - Perkin Transactions 1. 3471-3478. DOI: 10.1039/A701232B |
0.683 |
|
| 1997 |
Williams RV, Gadgil VR, Vij A, Cook JM, Kubiak G, Huang Q. Unexpected stereoselectivity in the Weiss-Cook condensation of dimethyl 1,3-acetonedicarboxylate with pentane-2,3-dione Journal of the Chemical Society - Perkin Transactions 1. 1425-1428. DOI: 10.1039/A605817E |
0.663 |
|
| 1997 |
Gan T, Liu R, Yu P, Zhao S, Cook JM. Enantiospecific Synthesis of Optically Active 6-Methoxytryptophan Derivatives and Total Synthesis of Tryprostatin A1 The Journal of Organic Chemistry. 62: 9298-9304. DOI: 10.1021/Jo971640W |
0.562 |
|
| 1997 |
Cox ED, Hamaker LK, Li J, Yu P, Czerwinski KM, Deng L, Bennett DW, Cook JM, Watson WH, Krawiec M. Enantiospecific formation of trans 1,3-disubstituted tetrahydro-β-carbolines by the Pictet-Spengler reaction and conversion of cis diastereomers into their trans counterparts by scission of the C-1/N-2 bond Journal of Organic Chemistry. 62: 44-61. DOI: 10.1021/jo951170a |
0.779 |
|
| 1997 |
Gan T, Van Ornum SG, Cook JM. The synthesis of GABAA active ligands by the stille process Tetrahedron Letters. 38: 8453-8456. DOI: 10.1016/S0040-4039(97)10278-7 |
0.381 |
|
| 1997 |
Peng Y, Wang T, Fuxiang Y, Cook JM. General Approach for the synthesis of macroline/sarpagine related indole alkaloids Via the asymmetric pictet-spengler reaction: the enantiospecific synthesis of the Na-H, azabicyclo[3.3.1]nonone template Tetrahedron Letters. 38: 6819-6822. DOI: 10.1016/S0040-4039(97)01603-1 |
0.393 |
|
| 1997 |
Gan T, Cook JM. Enantiospecific total synthesis of tryprostatin A Tetrahedron Letters. 38: 1301-1304. DOI: 10.1016/S0040-4039(97)00077-4 |
0.306 |
|
| 1997 |
Bloomquist JR, Ferguson HJ, Cox ED, Reddy MS, Cook JM. Mode of action of β-carboline convulsants on the insect nervous system and their potential as insecticides Pesticide Science. 51: 1-6. DOI: 10.1002/(Sici)1096-9063(199709)51:1<1::Aid-Ps586>3.0.Co;2-P |
0.555 |
|
| 1996 |
Liu R, Hu RJ, Zhang P, Skolnick P, Cook JM. Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABAA receptors. Journal of Medicinal Chemistry. 39: 1928-34. PMID 8627617 DOI: 10.1021/Jm950887N |
0.347 |
|
| 1996 |
Van Ornum SG, Cook JM. Generation of four five-membered rings in a one pot process. Studies directed toward the synthesis of dicyclopenta[a,d]pentalene via the tandem Pauson-Khand reaction Tetrahedron Letters. 37: 7185-7188. DOI: 10.1016/0040-4039(96)01634-6 |
0.315 |
|
| 1996 |
Gan T, Cook JM. General approach for the synthesis of macroline/sarpagine related indole alkaloids via the asymmetric Pictet-Spengler reaction: The enantiospecific synthesis of (−)-anhydromacrosalhine-methine Tetrahedron Letters. 37: 5033-5036. DOI: 10.1016/0040-4039(96)01009-X |
0.334 |
|
| 1995 |
Zhang P, Zhang W, Liu R, Harris B, Skolnick P, Cook JM. Synthesis of novel imidazobenzodiazepines as probes of the pharmacophore for "diazepam-insensitive" GABAA receptors. Journal of Medicinal Chemistry. 38: 1679-88. PMID 7752192 DOI: 10.1021/Jm00010A013 |
0.7 |
|
| 1995 |
Codding PW, Roszak AW, Szkaradzinska MB, Cook JM, Hagen TJ, Allen MS. Structure – activity relationships in antagonist and inverse agonist ligands for the benzodiazepine receptor Canadian Journal of Chemistry. 73: 499-512. DOI: 10.1139/V95-065 |
0.654 |
|
| 1995 |
Peterson AC, Cook JM. Studies Directed toward the Enantiospecific Synthesis of Gardneria, Voacanga, and Alstonia Oxindole Alkaloids The Journal of Organic Chemistry. 60: 120-129. DOI: 10.1021/Jo00106A024 |
0.331 |
|
| 1995 |
Cox ED, Cook JM. The pictet-spengler condensation: A new direction for an old reaction Chemical Reviews. 95: 1797-1842. DOI: 10.1021/Cr00038A004 |
0.512 |
|
| 1995 |
Zhang W, Liu R, Huang Q, Zhang P, Koehler KF, Harris B, Skolnick P, Cook JM. Syntheses of 5-thienyl and 5-furyl-substituted benzodiazepines: probes of the pharmacophore for benzodiazepine receptor agonists European Journal of Medicinal Chemistry. 30: 483-496. DOI: 10.1016/0223-5234(96)88259-6 |
0.677 |
|
| 1995 |
Zhang P, Liu R, Cook JM. A concise synthesis of optically active 2-bromotryptophan amino acids present in konbamide and jaspamide via a regiospecific bromination procedure Tetrahedron Letters. 36: 9133-9136. DOI: 10.1016/0040-4039(95)01956-I |
0.31 |
|
| 1995 |
Zhang P, Cook JM. A successful acid promoted asymmetric pictet-spengler reaction of Na-BOC protected tryptophans. Effect of the BOC group on reactivity and stereoselectivity Tetrahedron Letters. 36: 6999-7002. DOI: 10.1016/0040-4039(95)01448-Q |
0.32 |
|
| 1995 |
Zhang P, Liu R, Cook JM. Regiospecific bromination of 3-methylindoles with N-bromosuccinimide Tetrahedron Letters. 36: 3103-3106. DOI: 10.1016/0040-4039(95)00478-U |
0.324 |
|
| 1994 |
Ator NA, Cook JM, Allen MS, Griffiths RR. Discriminative-stimulus effects of azaspirodecanedione anxiolytics in baboons trained to discriminate beta-carboline-3-carboxylic acid ethyl ester or pentylenetetrazole. Behavioural Pharmacology. 5: 176-188. PMID 11224266 DOI: 10.1097/00008877-199404000-00009 |
0.467 |
|
| 1994 |
Zhang W, Koehler KF, Harris B, Skolnick P, Cook JM. Synthesis of benzo-fused benzodiazepines employed as probes of the agonist pharmacophore of benzodiazepine receptors. Journal of Medicinal Chemistry. 37: 745-57. PMID 8145224 DOI: 10.1021/Jm00032A007 |
0.664 |
|
| 1994 |
Wigler PW, Lyon KL, Patterson FK, La Loggia AJ, Diaz-Araúzo H, Reddy MS, Cook JM. Epoxide metabolite of quinine and inhibition of the multidrug resistance pump in human leukemic lymphoblasts. Molecular Pharmacology. 46: 562-7. PMID 7935339 |
0.772 |
|
| 1994 |
Bertz SH, Zhang W, Cook JM, Bruch MD, Jelinski LW. Weiss's endo- and exo-tetracyclo[5.5.1.0.2,6 010,13]tridecane-4,8,12-trione: analysis of 1H NMR couplings in a system of fused 5-membered rings Canadian Journal of Chemistry. 72: 1926-1932. DOI: 10.1139/V94-245 |
0.634 |
|
| 1994 |
Bi Y, Zhang LH, Hamaker LK, Cook JM. Enantiospecific synthesis of (-)-alstonerine and (+)-macroline as well as a partial synthesis of (+)-villalstonine Journal of the American Chemical Society. 116: 9027-9041. DOI: 10.1021/Ja00099A021 |
0.792 |
|
| 1994 |
Peterson AC, Cook JM. Studies on the enantiospecific synthesis of oxindole alkaloids Tetrahedron Letters. 35: 2651-2654. DOI: 10.1016/S0040-4039(00)76997-8 |
0.304 |
|
| 1994 |
Bi Y, Cook JM, LeQuesne PW. A partial synthesis of the Alstonia bisindole alkaloid villalstonine Tetrahedron Letters. 35: 3877-3878. DOI: 10.1016/S0040-4039(00)76690-1 |
0.784 |
|
| 1994 |
Reddy MS, Cook JM. The synthesis of roeharmine and (-)-1,2,3,4-tetrahydroroeharmine Tetrahedron Letters. 35: 5413-5416. DOI: 10.1016/S0040-4039(00)73513-1 |
0.335 |
|
| 1993 |
Wong G, Koehler KF, Skolnick P, Gu ZQ, Ananthan S, Schönholzer P, Hunkeler W, Zhang W, Cook JM. Synthetic and computer-assisted analysis of the structural requirements for selective, high-affinity ligand binding to diazepam-insensitive benzodiazepine receptors. Journal of Medicinal Chemistry. 36: 1820-30. PMID 8390574 DOI: 10.1021/Jm00065A004 |
0.656 |
|
| 1993 |
Bertz SH, Kourouklis GA, Jayaraman A, Lannoye G, Cook JM. High-pressure Raman studies of triquinacene and dodecahedrane Canadian Journal of Chemistry. 71: 352-357. DOI: 10.1139/V93-052 |
0.693 |
|
| 1993 |
Fu X, Cook JM. General approach for the synthesis of ajmaline-related alkaloids. Enantiospecific total synthesis of (-)-suaveoline, (-)-raumacline, and (-)-Nb-methylraumacline Journal of Organic Chemistry. 58: 661-672. DOI: 10.1021/Jo00055A019 |
0.361 |
|
| 1993 |
Fu X, Kubiak G, Zhang W, Han W, Gupta AK, Cook JM. General approach for the synthesis of polyquinenes via the Weiss reaction XV. Synthesis of the [5.5.5.5]fenestrane system via the aldol approach and studies directed toward the [5.5.6.6]fenestranes Tetrahedron. 49: 1511-1524. DOI: 10.1016/S0040-4020(01)80338-0 |
0.795 |
|
| 1993 |
Bi Y, Cook JM. General approach for the synthesis of macroline/sarpagine alkaloids. The total synthesis of (+)-macroline Tetrahedron Letters. 34: 4501-4504. DOI: 10.1016/0040-4039(93)88069-U |
0.534 |
|
| 1992 |
Takada K, Barrett JE, Allen MS, Cook JM, Katz JL. Punishment of schedule-controlled behavior with beta-carboline injections: antagonism and comparisons with other compounds. The Journal of Pharmacology and Experimental Therapeutics. 261: 138-45. PMID 1560359 |
0.319 |
|
| 1992 |
Allen MS, LaLoggia AJ, Dorn LJ, Martin MJ, Costantino G, Hagen TJ, Koehler KF, Skolnick P, Cook JM. Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach. Journal of Medicinal Chemistry. 35: 4001-10. PMID 1331452 DOI: 10.1021/Jm00100A004 |
0.741 |
|
| 1992 |
Allen MS, Skolnick P, Cook JM. Synthesis of novel 2-phenyl-2H-pyrazolo[4,3-c]isoquinolin-3-ols: topological comparisons with analogues of 2-phenyl-2,5-dihydropyrazolo[4,3-c]quinolin-3(3H)-ones at benzodiazepine receptors. Journal of Medicinal Chemistry. 35: 368-74. PMID 1310121 DOI: 10.1021/Jm00080A024 |
0.443 |
|
| 1992 |
Zhang LH, Bi YZ, Yu FX, Menzia G, Cook JM. Stereospecificity in the Pictet-Spengler reaction. Enantiospecific synthesis of (6s, 10s)-(-)-5-methyl-9-oxo-12-benzyl-6,7,8,9,10,11-hexahydro-6,10-imino-5H-cyclooct[b]indole, a template for preparation of macroline/sarpagine alkaloids Heterocycles. 34: 517-547. DOI: 10.3987/Com-91-5927 |
0.613 |
|
| 1992 |
Szkaradzinska MB, Roszak AW, Trudell ML, Cook JM, Codding PW. Structure of 2‐chloro‐7,12‐dihydropyrido[3,2‐b:5,4‐b']diindole Acta Crystallographica Section C. 48: 382-384. DOI: 10.1107/S0108270191009733 |
0.53 |
|
| 1992 |
Allen MS, Hamaker LK, La Loggia AJ, Cook JM. Entry into 6-Methoxy-D(+)-tryptophans. Stereospecific Synthesis of 1-Benzenesulfonyl-6-methoxy-D(+)-tryptophan Ethyl Ester Synthetic Communications. 22: 2077-2102. DOI: 10.1080/00397919208021343 |
0.797 |
|
| 1992 |
Fu X, Cook JM. General approach for the synthesis of polyquinenes via the Weiss reaction. 14. Synthesis of ellacene (1,10-decanotriquinacene) and studies of the proposed dimerization to a substituted dodecahedrane Journal of Organic Chemistry. 57: 5121-5128. DOI: 10.1021/Jo00045A023 |
0.357 |
|
| 1992 |
Czerwinski KM, Deng L, Cook JM. Mechanism driven trans stereospecificity in the Pictet-Spengler reaction. Stereospecific formation of trans-1,2,3-trisubstituted-tetrahydro β- carbolines by condensation of Nb-diphenylmethyl tryptophan isopropyl esters wtm aldehydes Tetrahedron Letters. 33: 4721-4724. DOI: 10.1016/S0040-4039(00)61268-6 |
0.798 |
|
| 1992 |
Trudell ML, Soerens D, Weber RW, Hutchins L, Grubisha D, Bennett D, Cook JM. Pictet-spengler reactions in aprotic media. The total synthesis of (±) suaveoline Tetrahedron. 48: 1805-1822. DOI: 10.1016/S0040-4020(01)88507-0 |
0.794 |
|
| 1991 |
Diaz-Arauzo H, Evoniuk GE, Skolnick P, Cook JM. The agonist pharmacophore of the benzodiazepine receptor. Synthesis of a selective anticonvulsant/anxiolytic. Journal of Medicinal Chemistry. 34: 1754-6. PMID 1674542 DOI: 10.1021/Jm00109A035 |
0.814 |
|
| 1991 |
Sannerud CA, Allen M, Cook JM, Griffiths RR. Behavioral effects of benzodiazepine ligands in non-dependent, diazepam-dependent and diazepam-withdrawn baboons. European Journal of Pharmacology. 202: 159-69. PMID 1666365 DOI: 10.1016/0014-2999(91)90290-7 |
0.463 |
|
| 1991 |
Diaz-Arauzo H, Koehler KF, Hagen TJ, Cook JM. Synthetic and computer assisted analysis of the pharmacophore for agonists at benzodiazepine receptors. Life Sciences. 49: 207-16. PMID 1648158 DOI: 10.1016/0024-3205(91)90005-V |
0.799 |
|
| 1991 |
Narayanan K, Cook JM. Carboxyl-mediated Pictet-Spengler reaction. Improved synthesis of 2,3,5,6,11,11b-hexahydro-3-oxo-1H-indolizino[8,7-b]indoles from tryptamine-2-carboxylic acids Journal of Organic Chemistry. 56: 5733-5736. DOI: 10.1021/Jo00019A056 |
0.311 |
|
| 1991 |
Narayanan K, Schindler L, Cook JM. Carboxyl-mediated Pictet-Spengler reaction. Direct synthesis of 1,2,3,4-tetrahydro-β-carbolines from Tryptamine-2-Carboxylic acids Journal of Organic Chemistry. 56: 359-365. DOI: 10.1021/Jo00001A066 |
0.326 |
|
| 1991 |
Deng L, Czerwinski K, Cook JM. Stereospecificity in the Pictet-Spengler reaction kinetic vs thermodynamic control Tetrahedron Letters. 32: 175-178. DOI: 10.1016/0040-4039(91)80847-Y |
0.793 |
|
| 1990 |
Díaz-Araúzo H, Cook JM, Christie DJ. Synthesis of 10,11-dihydroxydihydroquinidine N-oxide, a new metabolite of quinidine. Preparation and 1H-nmr spectroscopy of the metabolites of quinine and quinidine and conformational analysis via 2D COSY nmr spectroscopy. Journal of Natural Products. 53: 112-24. PMID 2348197 DOI: 10.1021/Np50067A015 |
0.776 |
|
| 1990 |
Trudell ML, Lifer SL, Tan YC, Martin MJ, Deng L, Skolnick P, Cook JM. Synthesis of substituted 7,12-dihydropyrido[3,2-b:5,4-b']diindoles: rigid planar benzodiazepine receptor ligands with inverse agonist/antagonist properties. Journal of Medicinal Chemistry. 33: 2412-20. PMID 2167978 DOI: 10.1021/Jm00171A015 |
0.793 |
|
| 1990 |
Hollinshead SP, Trudell ML, Skolnick P, Cook JM. Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester. Journal of Medicinal Chemistry. 33: 1062-9. PMID 1968513 DOI: 10.1021/Jm00165A028 |
0.612 |
|
| 1990 |
Cook JM, Diaz-Arauzo H, Allen MS. Inverse agonists, probes to study the structure, topology and function of the benzodiazepine receptor. Nida Research Monograph. 105: 133-9. PMID 1652068 |
0.79 |
|
| 1990 |
Narayanan K, Cook JM. Molecular yardsticks: Synthesis of higher homologs of 7,12-dihydropyrido[3,4-b: 5,4-b′]diindole. Probing the dimensions of the benzodiazepine receptor inverse agonist site Heterocycles. 31: 203-209. DOI: 10.3987/Com-89-5248 |
0.311 |
|
| 1990 |
Sambasivarao K, Hollinshead S, Grubisha D, Laib F, Bennett D, Cook JM. Synthetic approach to pentaleno[2,1-b:5,4-b′]diindoles Journal of Organic Chemistry. 55: 3858-3866. DOI: 10.1021/Jo00299A031 |
0.311 |
|
| 1990 |
Kubiak O, Fu X, Gupta AK, Cook JM. General approach for the synthesis of polyquinenes via the weiss reaction XIII. Aldol approach to fenestranes Tetrahedron Letters. 31: 4285-4288. DOI: 10.1016/S0040-4039(00)97602-0 |
0.343 |
|
| 1990 |
Fu X, Cook JM. General approach for the synthesis of polyquinenes via the weiss reaction XII. The chugaev approach to ellacene (1,10-cyclododecanotriquinancene) Tetrahedron Letters. 31: 3409-3412. DOI: 10.1016/S0040-4039(00)97409-4 |
0.337 |
|
| 1990 |
ZHANG L, TRUDELL ML, HOLLINSHEAD SP, COOK JM. ChemInform Abstract: (3,3) Sigmatropic Rearrangements in Indoloazabicyclo(3.3.1)nonene Systems. Reversal of the Stereofacial Selectivity in the Claisen vs the Ortho Ester Claisen Rearrangement. Cheminform. 21. DOI: 10.1002/chin.199005084 |
0.521 |
|
| 1990 |
TRUDELL ML, COOK JM. ChemInform Abstract: Total Synthesis of (.+-.)-Suaveoline. Cheminform. 21. DOI: 10.1002/chin.199002315 |
0.549 |
|
| 1989 |
Martin JV, Cook JM, Hagen TJ, Mendelson WB. Inhibition of sleep and benzodiazepine receptor binding by a beta-carboline derivative. Pharmacology, Biochemistry, and Behavior. 34: 37-42. PMID 2560549 DOI: 10.1016/0091-3057(89)90349-3 |
0.614 |
|
| 1989 |
Takada K, Suzuki T, Hagen T, Cook JM, Katz JL. Behavioral effects of benzodiazepine antagonists in chlordiazepoxide tolerant and non-tolerant rats. Life Sciences. 44: 289-99. PMID 2492629 DOI: 10.1016/0024-3205(89)90187-2 |
0.636 |
|
| 1989 |
Hagen TJ, Narayanan K, Names J, Cook JM. DDQ oxidations in the indole area. Synthesis of 4-alkoxy-.beta.-carbolines including the natural products crenatine and 1-methoxycanthin-6-one Journal of Organic Chemistry. 54: 2170-2178. DOI: 10.1021/Jo00270A029 |
0.622 |
|
| 1989 |
Zhang LH, Trudell ML, Hollinshead SP, Cook JM. [3,3]-Sigmatropic rearrangements in indoloazabicyclo[3.3.1]nonene systems. Reversal of the stereofacial selectivity in the Claisen vs. the ortho ester Claisen rearrangement Journal of the American Chemical Society. 111: 8263-8265. DOI: 10.1021/Ja00203A030 |
0.561 |
|
| 1989 |
Trudell ML, Cook JM. Total synthesis of (±)-suaveoline Journal of the American Chemical Society. 111: 7504-7507. DOI: 10.1021/Ja00201A034 |
0.59 |
|
| 1989 |
Gupta AK, Lannoye GS, Kubiak G, Schkeryantz J, Wehrli S, Cook JM. General approach to the synthesis of polyquinenes. 8. Synthesis of triquinacene, 1,10-dimethyltriquinacene, and 1,10-cyclohexanotriquinacene Journal of the American Chemical Society. 111: 2169-2179. DOI: 10.1021/Ja00188A035 |
0.79 |
|
| 1989 |
Ator NA, Cook JM, Griffiths RR. Drug discrimination in pentylenetetrazol-trained baboons: Generalization to buspirone and ?-carboline-3-carboxylic acid ethyl ester but not lorazepam or pentobarbital Drug Development Research. 16: 257-267. DOI: 10.1002/Ddr.430160219 |
0.308 |
|
| 1989 |
CODDING PW, SZKARADZINSKA MB, ROSZAK AW, AHA LJ, HAGEN TJ, COOK JM. ChemInform Abstract: Structure-Activity Studies of β-Carbolines. Part 4. Crystal and Molecular Structures of tert.-Butyl β-Carboline-3-carboxylate and 2-(Methoxycarbonyl)canthin-6-one. Cheminform. 20. DOI: 10.1002/chin.198921311 |
0.574 |
|
| 1989 |
TRUDELL ML, TAN Y, COOK JM. ChemInform Abstract: Regioselective Methylation of 7,12-Dihydropyrido(3,2-b:5,4-b′)diindole. Experimental and Computational Results. Cheminform. 20. DOI: 10.1002/chin.198911323 |
0.498 |
|
| 1989 |
TRUDELL ML, LIFER SL, TAN Y, ENGLAND WB, COOK JM. ChemInform Abstract: Reactivity of 7,12-Dihydropyrido(3,2-b:5,4-b′)diindole with Electrophilic Reagents. Experimental and Computational Results. Cheminform. 20. DOI: 10.1002/chin.198905182 |
0.767 |
|
| 1989 |
TAN Y, TRUDELL ML, COOK JM. ChemInform Abstract: Synthesis of 7,12-Dihydropyridopyrroloindoles (Azapyridodiindoles) via the Fischer Indole Cyclization. A Search for Water Soluble Benzodiazepine Receptor Ligands. Cheminform. 20. DOI: 10.1002/chin.198901174 |
0.565 |
|
| 1989 |
Hagen TJ, Narayanan K, Names J, Cook JM. DDQ oxidations in the indole area. Synthesis of 4-alkoxy-β-carbolines including the natural products crenatine and 1-methoxycanthin-6-one Journal of Organic Chemistry. 54: 2170-2178. |
0.59 |
|
| 1988 |
Christie DJ, Diaz-Arauzo H, Cook JM. Antibody-mediated platelet destruction by quinine, quinidine, and their metabolites. The Journal of Laboratory and Clinical Medicine. 112: 92-8. PMID 3392460 |
0.777 |
|
| 1988 |
Takada K, Hagen TJ, Cook JM, Goldberg SR, Katz JL. Discriminative stimulus effects of intravenous nicotine in squirrel monkeys. Pharmacology, Biochemistry, and Behavior. 30: 243-7. PMID 3174749 DOI: 10.1016/0091-3057(88)90452-2 |
0.618 |
|
| 1988 |
Trullas R, Ginter H, Jackson B, Skolnick P, Allen MS, Hagen TJ, Cook JM. 3-Ethoxy-beta-carboline: a high affinity benzodiazepine receptor ligand with partial inverse agonist properties. Life Sciences. 43: 1189-97. PMID 2845211 DOI: 10.1016/0024-3205(88)90208-1 |
0.701 |
|
| 1988 |
Allen MS, Hagen TJ, Trudell ML, Codding PW, Skolnick P, Cook JM. Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. Journal of Medicinal Chemistry. 31: 1854-61. PMID 2842507 DOI: 10.1021/Jm00117A029 |
0.759 |
|
| 1988 |
Zhang Lh, Cook JM. Pictet-Spengler reactions in aprotic media. Nb-benzyl promoted retention of optical activity in the synthesis of an indolo substituted azabicyclo[3.3.1]nonane, a key template for the synthesis of macroline alkaloids Heterocycles. 27: 2795-2802. DOI: 10.3987/Com-88-4755 |
0.492 |
|
| 1988 |
Zhang LH, Cook JM. Pictet-spengler reactions in aprotic media. Stereospecific conversion of optically active cis-1,3-disubstituted 1,2,3,4-tetrahydro-β-carbolines into their corresponding trans diastereomers Heterocycles. 27: 1357-1363. DOI: 10.3987/Com-88-4554 |
0.484 |
|
| 1988 |
Codding PW, Szkaradzinska MB, Roszak AW, Aha LJ, Hagen TJ, Cook JM. Structure-activity studies of β-carbolines. 4. Crystal and molecular structures of t-butyl β-carboline-3-carboxylate and 2-(methoxycarbonyl)canthine-6-one Canadian Journal of Chemistry. 66: 2981-2988. DOI: 10.1139/V88-463 |
0.645 |
|
| 1988 |
Sambasivarao K, Kubiak G, Lannoye G, Cook JM. General approach to the synthesis of polyquinenes. 9. The monofunctionalization and alteration of the symmetry of the cis-bicyclo[3.3.0]octane-3,7-dione unit Journal of Organic Chemistry. 53: 5173-5175. DOI: 10.1021/Jo00256A057 |
0.781 |
|
| 1988 |
Trudell ML, Tan YC, Cook JM. Regioselective methylation of 7,12-dihydropyrido[3,2-b:5,4-b']diindole. Experimental and computational results The Journal of Organic Chemistry. 53: 4873-4875. DOI: 10.1021/Jo00255A043 |
0.542 |
|
| 1988 |
Trudell ML, Lifer SL, Tan YC, England WB, Cook JM. Reactivity of 7,12-dihydropyrido[3,2-b:5,4-b']diindole with electrophilic reagents. Experimental and computational results The Journal of Organic Chemistry. 53: 4185-4190. DOI: 10.1021/Jo00253A006 |
0.763 |
|
| 1988 |
Lannoye G, Sambasivarao K, Wehrli S, Cook JM, Weiss U. General approach to the synthesis of polyquinenes via the weiss reaction. 6. Progress toward the synthesis of dicyclopentapentalenes Journal of Organic Chemistry. 53: 2327-2340. DOI: 10.1021/Jo00245A037 |
0.724 |
|
| 1988 |
Hagen TJ, Cook JM. Synthesis of 1-methoxy canthine-6-one Tetrahedron Letters. 29: 2421-2424. DOI: 10.1016/S0040-4039(00)87897-1 |
0.66 |
|
| 1988 |
Gupta AK, Cook JM, Weiss U. General approach to the synthesis of polyquinenes VII. Synthesis of a centro-substituted triquinacene Tetrahedron Letters. 29: 2535-2538. DOI: 10.1016/S0040-4039(00)86105-5 |
0.361 |
|
| 1988 |
Lannoye G, Cook JM. General approach to the synthesis of polyquinenes via the weiss reaction. V. Progress toward the synthesis of dicyclopentapentalenes Tetrahedron Letters. 29: 171-174. DOI: 10.1016/S0040-4039(00)80044-1 |
0.72 |
|
| 1988 |
HAGEN TJ, COOK JM. ChemInform Abstract: Synthesis of 1-Methoxycanthine-6-one (VIII). Cheminform. 19. DOI: 10.1002/chin.198843351 |
0.618 |
|
| 1987 |
Hagen TJ, Skolnick P, Cook JM. Synthesis of 6-substituted beta-carbolines that behave as benzodiazepine receptor antagonists or inverse agonists. Journal of Medicinal Chemistry. 30: 750-3. PMID 3031296 DOI: 10.1021/Jm00387A033 |
0.66 |
|
| 1987 |
Trudell ML, Basile AS, Shannon HE, Skolnick P, Cook JM. Synthesis of 7,12-dihydropyrido[3,4-b:5,4-b']diindoles. A novel class of rigid, planar benzodiazepine receptor ligands. Journal of Medicinal Chemistry. 30: 456-8. PMID 3029372 DOI: 10.1021/Jm00386A003 |
0.595 |
|
| 1987 |
Codding PW, Szkaradzinska MB, Cook JM, Hagen TJ. Mapping the β-carboline binding site on the benzodiazepine receptor oligomer Acta Crystallographica Section a Foundations of Crystallography. 43: C47-C47. DOI: 10.1107/S0108767387084241 |
0.59 |
|
| 1987 |
Trudell ML, Fukada N, Cook JM. Hydrazine-mediated one-pot amination-oxidation reaction: facile synthesis of 4-amino-.beta.-carbolines and 4-aminoisoquinolines Journal of Organic Chemistry. 52: 4293-4296. DOI: 10.1021/Jo00228A025 |
0.591 |
|
| 1987 |
Venkatachalam M, Wehrli S, Kubiak G, Cook JM, Weiss U. General approach to the synthesis of polyquinanes. Preparation of trans,trans -4,8-diacetoxytetracyclo[9.3.0.01,5 .07,11]-tetradecan-6-one Journal of Organic Chemistry. 52: 4110-4115. DOI: 10.1021/Jo00227A030 |
0.686 |
|
| 1987 |
Lannoye G, Cook JM. General approach to the synthesis of polyquinenes. IV. Studies directed toward the preparation of dicyclopenta[cd,gh]pentalene. Tetrahedron Letters. 28: 4821-4824. DOI: 10.1016/S0040-4039(00)96634-6 |
0.734 |
|
| 1987 |
HAGEN TJ, GUZMAN F, SCHULTZ C, COOK JM, SKOLNICK P, SHANNON HE. ChemInform Abstract: Synthesis of 3,6-Disubstituted β-Carbolines which Possess Either Benzodiazepine Antagonist or Agonist Activity. Cheminform. 18. DOI: 10.1002/chin.198712218 |
0.633 |
|
| 1987 |
Trudell ML, Fukada N, Cook JM. Hydrazine-mediated one-pot amination-oxidation reaction: Facile synthesis of 4-amino-β-carbolines and 4-aminoisoquinolines Journal of Organic Chemistry. 52: 4293-4296. |
0.551 |
|
| 1986 |
Hoffman WE, Albrecht RF, Miletich DJ, Hagen TJ, Cook JM. Cerebrovascular and cerebral metabolic effects of physostigmine, midazolam, and a benzodiazepine antagonist. Anesthesia and Analgesia. 65: 639-44. PMID 2939779 DOI: 10.1213/00000539-198606000-00013 |
0.625 |
|
| 1986 |
Venkatachalam M, Wehrli S, Kubiak G, Cook JM, Weiss U. General approach to the synthesis of polyquinanes. Preparation of trans, Trans-4,8-diacetoxy-tetracyclo[9.3.0.0.1.5.07,11]T etradeca-6-one via the aldol approach. Tetrahedron Letters. 27: 4111-4114. DOI: 10.1016/S0040-4039(00)84923-0 |
0.668 |
|
| 1986 |
Venkatachalam M, Deshpande M, Jawdosiuk M, Kubiak G, Wehrli S, Cook J, Weiss U. General approach for the synthesis of polyquinenes Tetrahedron. 42: 1597-1605. DOI: 10.1016/S0040-4020(01)87576-1 |
0.682 |
|
| 1986 |
VENKATACHALAM M, WEHRLI S, KUBIAK G, COOK JM, WEISS U. ChemInform Abstract: General Approach to the Synthesis of Polyquinanes. Preparation of trans,trans- 4,8-Diacetoxy-tetracyclo[9.3.0.01,5.07,11]tetradeca-6-one via the Aldol Approach. Chemischer Informationsdienst. 17. DOI: 10.1002/Chin.198652130 |
0.697 |
|
| 1986 |
BERTZ SH, LANNOYE G, COOK JM. ChemInform Abstract: General Approach to the Synthesis of Polyquinenes. Part 3. The Synthesis of Triquinacene via the Weiss Reaction. Chemischer Informationsdienst. 17. DOI: 10.1002/Chin.198611167 |
0.746 |
|
| 1985 |
Van Gorder PN, Hoffman WE, Baughman V, Albrecht RF, Miletich DJ, Guzman F, Cook JM. Midazolam-ethanol interactions and reversal with a benzodiazepine antagonist. Anesthesia and Analgesia. 64: 129-35. PMID 2857540 DOI: 10.1213/00000539-198502000-00006 |
0.586 |
|
| 1985 |
Kubiak G, Cook JM, Weiss U. Studies on the reaction of 1,2-dicarbonyl compounds with dimethyl 3-ketoglutarate. Steric and electronic effects Tetrahedron Letters. 26: 2163-2166. DOI: 10.1016/S0040-4039(00)98951-2 |
0.678 |
|
| 1985 |
Fukada N, Trudell ML, Johnson B, Cook JM. Synthetic studies in the β-carboline area new entry into4-substituted and 3,4-disubstituied β-carbolines Tetrahedron Letters. 26: 2139-2142. DOI: 10.1016/S0040-4039(00)98945-7 |
0.575 |
|
| 1985 |
Venkatachalam M, Jawdosiuk M, Deshpande M, Cook J. General approach for the synthesis of polyquinenes the weiss reaction. Preparation of the chiral tetracyclo [6.6.0.01,5.08,12]tetradecane-3,6,10,13,-tetraene Tetrahedron Letters. 26: 2275-2278. DOI: 10.1016/S0040-4039(00)95073-1 |
0.341 |
|
| 1985 |
Venkatachalam M, Kubiak G, Cook JM, Weiss U. General approach for the synthesis of polyquinanes Tetrahedron Letters. 26: 4863-4866. DOI: 10.1016/S0040-4039(00)94971-2 |
0.645 |
|
| 1985 |
Bertz SH, Lannoye G, Cook JM. The synthesis of triquinacene via the weiss reaction. Tetrahedron Letters. 26: 4695-4698. DOI: 10.1016/S0040-4039(00)94926-8 |
0.746 |
|
| 1985 |
Deshpande MN, Jawdosiuk M, Kubiak G, Venkatachalam M, Weiss U, Cook JM. General approach for the synthesis of polyquinenes. 2. Synthesis of tetracyclo[5.5.1.04,13.010,13]tridecane-2,5,8,11-tetraene Journal of the American Chemical Society. 107: 4786-4788. DOI: 10.1002/Chin.198547143 |
0.683 |
|
| 1985 |
FUKADA N, TRUDELL ML, JOHNSON B, COOK JM. ChemInform Abstract: SYNTHETIC STUDIES IN THE β-CARBOLINE AREA. NEW ENTRY INTO 4-SUBSTITUTED AND 3,4-DISUBSTITUTED β-CARBOLINES Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198534238 |
0.513 |
|
| 1984 |
Christie DJ, Weber RW, Mullen PC, Cook JM, Aster RH. Structural features of the quinidine and quinine molecules necessary for binding of drug-induced antibodies to human platelets. The Journal of Laboratory and Clinical Medicine. 104: 730-40. PMID 6491470 DOI: 10.5555/Uri:Pii:0022214384902646 |
0.475 |
|
| 1984 |
Guzman F, Cain M, Larscheid P, Hagen T, Cook JM, Schweri M, Skolnick P, Paul SM. Biomimetic approach to potential benzodiazepine receptor agonists and antagonists. Journal of Medicinal Chemistry. 27: 564-70. PMID 6325688 DOI: 10.1002/Chin.198443191 |
0.798 |
|
| 1984 |
Shannon HE, Guzman F, Cook JM. beta-Carboline-3-carboxylate-t-butyl ester: a selective BZ1 benzodiazepine receptor antagonist. Life Sciences. 35: 2227-36. PMID 6094935 DOI: 10.1016/0024-3205(84)90464-8 |
0.587 |
|
| 1984 |
Kubiak G, Cook JM, Weiss U. Isolation of the key intermediate in the formation of cis-bicyclo[3.3.0]octane-3,7-diones from dimethyl 3-ketoglutarate and 1,2-dicarbonyl compounds The Journal of Organic Chemistry. 49: 561-564. DOI: 10.1002/Chin.198429165 |
0.666 |
|
| 1983 |
Mendelson WB, Cain M, Cook JM, Paul SM, Skolnick P. A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flurazepam. Science (New York, N.Y.). 219: 414-6. PMID 6294835 DOI: 10.1126/Science.6294835 |
0.508 |
|
| 1983 |
Ninan PT, Insel TM, Cohen RM, Cook JM, Skolnick P, Paul SM. Benzodiazepine receptor-mediated experimental "anxiety" in primates. Science (New York, N.Y.). 218: 1332-4. PMID 6293059 DOI: 10.1126/Science.6293059 |
0.352 |
|
| 1983 |
Wrobel J, Takahashi K, Honkan V, Lannoye G, Cook JM, Bertz SH. .alpha.-Lithio ketones. 1. Stereocontrolled synthesis of (.+-.)-modhephene via the Weiss reaction The Journal of Organic Chemistry. 48: 139-141. DOI: 10.1021/Jo00149A034 |
0.306 |
|
| 1983 |
Cain M, Campos O, Guzman F, Cook JM. Selenium dioxide oxidations in the indole area. Synthesis of β-carboline alkaloids Journal of the American Chemical Society. 105: 907-913. DOI: 10.1021/Ja00342A045 |
0.52 |
|
| 1983 |
WROBEL J, TAKAHASHI K, HONKAN V, LANNOYE G, COOK JM, BERTZ SH. ChemInform Abstract: α-LITHIO KETONES. 1. STEREOCONTROLLED SYNTHESIS OF (.+-.)-MODHEPHENE VIA THE WEISS REACTION Chemischer Informationsdienst. 14. DOI: 10.1002/Chin.198326154 |
0.723 |
|
| 1983 |
LEE S, COOK JM. ChemInform Abstract: SYNTHESIS OF AZAPHENALENES Chemischer Informationsdienst. 14. DOI: 10.1002/Chin.198325359 |
0.411 |
|
| 1983 |
WEBER RW, COOK JM. ChemInform Abstract: SYNTHESIS OF 9-METHOXY-1,6-DIAZAPHENALENE Chemischer Informationsdienst. 14. DOI: 10.1002/Chin.198315245 |
0.331 |
|
| 1983 |
CAIN M, WEBER RW, GUZMAN F, COOK JM, BARKER SA, RICE KC, CRAWLEY JN, PAUL SM, SKOLNICK P. ChemInform Abstract: β-CARBOLINES: SYNTHESIS AND NEUROCHEMICAL AND PHARMACOLOGICAL ACTIONS ON BRAIN BENZODIAZEPINE RECEPTORS Chemischer Informationsdienst. 14. DOI: 10.1002/Chin.198305238 |
0.563 |
|
| 1982 |
Mendelson WB, Cain M, Cook JM, Paul SM, Skolnick P. Do benzodiazepine receptors play a role in sleep regulation? Studies with the benzodiazepine antagonist, 3-hydroxymethyl-beta-carboline (3-HMC). Progress in Clinical and Biological Research. 90: 253-61. PMID 6287492 |
0.461 |
|
| 1982 |
Skolnick P, Williams EF, Cook JM, Cain M, Rice KC, Mendelson WB, Crawley JN, Paul SM. beta-Carbolines and benzodiazepine receptors: structure-activity relationships and pharmacologic activity. Progress in Clinical and Biological Research. 90: 233-52. PMID 6287491 |
0.477 |
|
| 1982 |
Cain M, Weber RW, Guzman F, Cook JM, Barker SA, Rice KC, Crawley JN, Paul SM, Skolnick P. Beta-carbolines: synthesis and neurochemical and pharmacological actions on brain benzodiazepine receptors. Journal of Medicinal Chemistry. 25: 1081-91. PMID 6127411 DOI: 10.1021/Jm00351A015 |
0.731 |
|
| 1982 |
Weber RW, Lee S, Milosevich S, England WB, Cook JM. Halogenation of 1,6-diazaphenalene. Theoretical and experimental results Canadian Journal of Chemistry. 60: 3049-3054. DOI: 10.1139/V82-436 |
0.382 |
|
| 1982 |
Avasthi K, Cook JM. Chemistry of 1,6-diazaphenalene. Reaction with alkylating and acylating agents Journal of Heterocyclic Chemistry. 19: 1415-1419. DOI: 10.1002/Jhet.5570190632 |
0.332 |
|
| 1982 |
MITSCHKA R, OEHLDRICH J, TAKAHASHI K, COOK JM, WEISS U, SILVERTON JV. ChemInform Abstract: GENERAL APPROACH FOR THE SYNTHESIS OF POLYQUINANES. FACILE GENERATION OF MOLECULAR COMPLEXITY VIA REACTION OF 1,2-DICARBONYL COMPOUNDS WITH DIMETHYL 3-OXOGLUTARATE Chemischer Informationsdienst. 13. DOI: 10.1002/chin.198217144 |
0.767 |
|
| 1982 |
AVASTHI K, LEE S, COOK JM, PICKETT JE, WASSERMAN HH. ChemInform Abstract: THE CHEMISTRY OF 1,6-DIAZAPHENALENE. ELECTROPHILIC SUBSTITUTION AND REACTION WITH SINGLET OXYGEN Chemischer Informationsdienst. 13. DOI: 10.1002/Chin.198208249 |
0.37 |
|
| 1981 |
Skolinick P, Paul S, Crawley J, Rice K, Barker S, Weber R, Cain M, Cook J. 3-hydroxymethyl-beta-carboline antagonizes some pharmacologic actions of diazepam. European Journal of Pharmacology. 69: 525-7. PMID 6265233 DOI: 10.1016/0014-2999(81)90462-3 |
0.602 |
|
| 1981 |
Chang JC, El-Sheikh M, Harmon A, Avasthi K, Cook JM. Synthesis of 1,6-diazaphenalene The Journal of Organic Chemistry. 46: 4188-4193. DOI: 10.1021/Jo00334A016 |
0.318 |
|
| 1981 |
Ungemach F, DiPierro M, Weber R, Cook JM. Stereospecific synthesis of trans-1,3-disubstituted-1,2,3,4-tetrahydro-.beta.-carbolines The Journal of Organic Chemistry. 46: 164-168. DOI: 10.1021/Jo00314A035 |
0.656 |
|
| 1981 |
Avasthi K, Deshpande M, Han W, Cook J, Weiss U. Reaction of dicarbonyl compounds with dimethyl 3-ketoglutarate. Influence of steric effects on success of the condensation Tetrahedron Letters. 22: 3475-3478. DOI: 10.1016/S0040-4039(01)81935-3 |
0.338 |
|
| 1981 |
Gawish A, Mitschka R, Cook JM, Weiss U. General approach for the synthesis of polyquinanes: stereospecific, regiospecific entry into the tetracyclo-[6.6.0.01,5.08,12]tetradecane system Tetrahedron Letters. 22: 211-214. DOI: 10.1016/0040-4039(81)80057-3 |
0.79 |
|
| 1981 |
Mitschka R, Oehldrich J, Takahashi K, Cook JM, Weiss U, Silverton JV. General approach for the synthesis of polyquinanes. Facile generation of molecular complexity via reaction of 1,2-dicarbonyl compounds with dimethyl 3- Tetrahedron. 37: 4521-4542. DOI: 10.1016/0040-4020(81)80020-8 |
0.791 |
|
| 1980 |
Wrobel J, Cook JM. A Convenient Preparation of Cyclopentane-1,2-Dione Synthetic Communications. 10: 333-337. DOI: 10.1080/00397918008062758 |
0.35 |
|
| 1980 |
Ungemach F, Soerens D, Weber R, DiPierro M, Campos O, Mokry P, Cook JM, Silverton JV. General method for the assignment of stereochemistry of 1,3-disubstituted 1,2,3,4-tetrahydro-.beta.-carbolines by carbon-13 spectroscopy Journal of the American Chemical Society. 102: 6976-6984. DOI: 10.1021/Ja00543A012 |
0.765 |
|
| 1979 |
Soerens D, Sandrin J, Ungemach F, Mokry P, Wu GS, Yamanaka E, Hutchins L, DiPierro M, Cook JM. Study of the Pictet-Spengler reaction in aprotic media: synthesis of the .beta.-galactosidase inhibitor, pyridindolol The Journal of Organic Chemistry. 44: 535-545. DOI: 10.1021/Jo01318A014 |
0.786 |
|
| 1979 |
Ungemach F, DiPierro M, Weber R, Cook JM. Stereospecific synthesis of trans-1,3-disubstituted-1,2,3,4-tetrahydro β-carbolines Tetrahedron Letters. 20: 3225-3228. DOI: 10.1016/S0040-4039(01)95369-9 |
0.675 |
|
| 1979 |
Campos O, Cook JM. Selenium dioxide entry into 3-acylindoles Tetrahedron Letters. 20: 1025-1028. DOI: 10.1016/S0040-4039(01)87180-X |
0.607 |
|
| 1979 |
UNGEMACH F, DIPIERRO M, WEBER R, COOK JM. ChemInform Abstract: STEREOSPECIFIC SYNTHESIS OF TRANS-1,3-DISUBSTITUTED-1,2,3,4-TETRAHYDRO β-CARBOLINES Chemischer Informationsdienst. 10. DOI: 10.1002/chin.197949231 |
0.544 |
|
| 1979 |
CHENG J, EL-SHEIKH MI, COOK JM. ChemInform Abstract: SYNTHESIS OF 1,6-DIAZAPHENALENE, A VINYLOGOUS IMIDAZOLE Chemischer Informationsdienst. 10. DOI: 10.1002/Chin.197948258 |
0.334 |
|
| 1979 |
SOERENS D, SANDRIN J, UNGEMACH F, MOKRY P, WU GS, YAMANAKA E, HUTCHINS L, DIPIERRO M, COOK JM. ChemInform Abstract: STUDY OF THE PICTET-SPENGLER REACTION IN APROTIC MEDIA: SYNTHESIS OF THE β-GALACTOSIDASE INHIBITOR, PYRIDINDOLOL Chemischer Informationsdienst. 10. DOI: 10.1002/chin.197926269 |
0.55 |
|
| 1978 |
Weber RW, Cook JM. General method for the synthesis of [n.3.3]propellanes, n ≥ 3 Canadian Journal of Chemistry. 56: 189-192. DOI: 10.1139/V78-030 |
0.322 |
|
| 1978 |
Mitschka R, Cook JM, Weiss U. Synthesis of a tetraketone of the tetracyclo[5.5.1.04,13.010,13]tridecane ("staurane") series Journal of the American Chemical Society. 100: 3973-3974. DOI: 10.1021/Ja00480A078 |
0.323 |
|
| 1978 |
UNGEMACH F, COOK JM. ChemInform Abstract: THE SPIROINDOLENINE INTERMEDIATE. A REVIEW Chemischer Informationsdienst. 9. DOI: 10.1002/Chin.197849251 |
0.544 |
|
| 1977 |
Oehldrich J, Cook JM. Reactions of dicarbonyl compounds with β-ketoglutaric acid: synthesis of 4-hydroxy-3,4-diphenylcyclopent-2-enone-2-carboxylic acid Canadian Journal of Chemistry. 55: 82-84. DOI: 10.1139/V77-015 |
0.777 |
|
| 1977 |
Oehldrich J, Cook JM. Reactions of dicarbonyl compounds with dimethyl .beta.-ketoglutarate. 6. Revision of the structure of the reaction product of cyclohexane-1,3-dione and dimethyl .beta.-ketoglutarate and conversion to 4-substituted 5,6,7,8-tetrahydro-5-oxo-2-quinolones The Journal of Organic Chemistry. 42: 889-894. DOI: 10.1021/Jo00425A028 |
0.771 |
|
| 1977 |
Campos O, Cook JM. Reaction of carbonyl compounds with dimethyl 3-ketoglutarate. Synthesis of bicyclic furan derivatives Journal of Heterocyclic Chemistry. 14: 711-715. DOI: 10.1002/Jhet.5570140501 |
0.657 |
|
| 1977 |
OEHLDRICH J, COOK JM. ChemInform Abstract: REACTIONS OF DICARBONYL COMPOUNDS WITH DIMETHYL β-KETOGLUTARATE. 6. REVISION OF THE STRUCTURE OF THE REACTION PRODUCT OF CYCLOHEXANE-1,3-DIONE AND DIMETHYL β-KETOGLUTARATE AND CONVERSION TO 4-SUBSTITUTED 5,6,7,8-TETRAHYDRO-5-OXO-2-QUI Chemischer Informationsdienst. 8: no-no. DOI: 10.1002/chin.197725256 |
0.763 |
|
| 1977 |
OEHLDRICH J, COOK JM. ChemInform Abstract: REACTIONS OF DICARBONYL COMPOUNDS WITH β-OXOGLUTARIC ACID- SYNTHESIS OF 4-HYDROXY-3,4-DIPHENYLCYCLOPENT-2-ENONE-2-CARBOXYLIC ACID Chemischer Informationsdienst. 8: no-no. DOI: 10.1002/chin.197719170 |
0.768 |
|
| 1977 |
YANG-LAN S, MUELLER-JOHNSON M, OEHLDRICH J, WICHMAN D, COOK JM, WEISS U. ChemInform Abstract: REACTIONS OF DIMETHYL β-KETOGLUTARATE WITH 1,2-DICARBONYL COMPOUNDS. 6. REACTIONS OF DICARBONYL COMPOUNDS WITH DIMETHYL β-KETOGLUTARATE. 4. FORMATION OF 1-1 ADDUCTS Chemischer Informationsdienst. 8: no-no. DOI: 10.1002/chin.197715089 |
0.758 |
|
| 1977 |
OEHLDRICH J, COOK JM, WEISS U. ChemInform Abstract: REACTIONS OF DICARBONYL COMPOUNDS WITH DIMETHYL β-KETOGLUTARATE. V. SIMPLE SYNTHESIS OF TRICYCLO(6.3.0.01,5)UNDECANE-3,7,9-TRIONE, A NOVEL CYCLOPENTANOID COMPOUND Chemischer Informationsdienst. 8: no-no. DOI: 10.1002/chin.197713172 |
0.766 |
|
| 1976 |
Yang-Lan S, Mueller-Johnson M, Oehldrich J, Wichman D, Cook JM, Weiss U. Reactions of dimethyl .beta.-ketoglutarate with 1,2-dicarbonyl compounds. 6. Reactions of dicarbonyl compounds with dimethyl .beta.-ketoglutarate. 4. Formation of 1:1 adducts The Journal of Organic Chemistry. 41: 4053-4058. DOI: 10.1021/Jo00888A001 |
0.767 |
|
| 1976 |
Yang D, Cook JM. Reactions of dicarbonyl compounds with dimethyl .beta.-ketoglutarate: II. Simple synthesis of compounds of the [10.3.3]- and [6.3.3]-propellane series The Journal of Organic Chemistry. 41: 1903-1907. DOI: 10.1021/Jo00873A004 |
0.315 |
|
| 1976 |
Yang D, Foerst D, Oehldrich J, Cook JM. Reaction of 1,2- and 1,3-dicarbonyl compounds with dimethyl .beta.-ketoglutarate. I. Synthesis of methyl 5,6,7,8-tetrahydro-5-oxocoumarin-.DELTA. 4(3H),.alpha.-acetate The Journal of Organic Chemistry. 41: 743-744. DOI: 10.1021/jo00866a050 |
0.765 |
|
| 1976 |
Oehldrich J, Cook JM, Weiss U. Reactions of dicarbonyl compounds with dimethyl β-ketoglutarate V. Simple synthesis of tricyclo [6.3.0.01,5] Undecane-3, 7, 9-trione, a novel cyclopentanoid compound Tetrahedron Letters. 17: 4549-4552. DOI: 10.1016/S0040-4039(00)93928-5 |
0.776 |
|
| 1976 |
SANDRIN J, SOERENS D, HUTCHINS L, RICHFIELD E, UNGEMACH F, COOK JM. ChemInform Abstract: PICTET-SPENGLER CONDENSATIONS IN REFLUXING BENZENE Chemischer Informationsdienst. 7: no-no. DOI: 10.1002/Chin.197644240 |
0.779 |
|
| 1976 |
YANG D, FOERST D, OEHLDRICH J, COOK JM. ChemInform Abstract: REACTION OF 1,2- AND 1,3-DICARBONYL COMPOUNDS WITH DIMETHYL β-KETOGLUTARATE. I. SYNTHESIS OF METHYL 5,6,7,8-TETRAHYDRO-5-OXOCOUMARIN-Δ 4(3H),α-ACETATE Chemischer Informationsdienst. 7: no-no. DOI: 10.1002/chin.197622216 |
0.771 |
|
| 1975 |
KUTNEY JP, COOK J, FUJI K, TREASURYWALA AM, CLARDY J, FAYOS J, WRIGHT C. ChemInform Abstract: STUDIES ON THE SYNTHESIS OF BISINDOLE ALKALOIDS. THE SYNTHESIS, STRUCTURE AND ABSOLUTE CONFIGURATION OF 18′-EPI-4′-DEOXO-EPIVINBLASTINE, 18′-DECARBOMETHOXY-18′-EPI-4′-EPIVINBLASTINE AND 18′-EPI-3′,4′-DEHYDROVINBLASTINE Chemischer Informationsdienst. 6: no-no. DOI: 10.1002/Chin.197532395 |
0.754 |
|
| 1974 |
KUTNEY JP, COOK G, COOK J, ITOH I, CLARDY J, FAYOS J, BROWN P, SVOBODA GH. ChemInform Abstract: STUDIES ON VINCA ALKALOIDS, THE STRUCTURE OF VINCARODINE Chemischer Informationsdienst. 5. DOI: 10.1002/Chin.197437093 |
0.486 |
|
| 1973 |
Burke DE, Cook JM, Le Quesne PW. Biomimetic synthesis of the bisindole alkaloids villalstonine and alstonisidine Journal of the American Chemical Society. 95: 546-552. DOI: 10.1021/Ja00783A039 |
0.328 |
|
| 1972 |
Burke DE, DeMarkey CA, Quesne PWL, Cook JM. Biomimetic synthesis of the bis-indole alkaloid macralstonine Journal of the Chemical Society, Chemical Communications. 1346-1347. DOI: 10.1039/C39720001346 |
0.344 |
|
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