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Rakesh Nagarajan, Ph.D. - Publications

Affiliations: 
Washington University, Saint Louis, St. Louis, MO 
Area:
Axonal degeneration, peripheral neuropathy, Myelination, Schwann cell metabolism
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54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Olfson E, Cottrell CE, Davidson NO, Gurnett CA, Heusel JW, Stitziel NO, Chen LS, Hartz S, Nagarajan R, Saccone NL, Bierut LJ. Identification of Medically Actionable Secondary Findings in the 1000 Genomes. Plos One. 10: e0135193. PMID 26332594 DOI: 10.1371/Journal.Pone.0135193  0.318
2014 Cottrell CE, Al-Kateb H, Bredemeyer AJ, Duncavage EJ, Spencer DH, Abel HJ, Lockwood CM, Hagemann IS, O'Guin SM, Burcea LC, Sawyer CS, Oschwald DM, Stratman JL, Sher DA, Johnson MR, ... ... Nagarajan R, et al. Validation of a next-generation sequencing assay for clinical molecular oncology. The Journal of Molecular Diagnostics : Jmd. 16: 89-105. PMID 24211365 DOI: 10.1016/J.Jmoldx.2013.10.002  0.506
2013 Sharma MK, Phillips J, Agarwal S, Wiggins WS, Shrivastava S, Koul SB, Bhattacharjee M, Houchins CD, Kalakota RR, George B, Meyer RR, Spencer DH, Lockwood CM, Nguyen TT, Duncavage EJ, ... ... Nagarajan R, et al. Clinical genomicist workstation. Amia Joint Summits On Translational Science Proceedings Amia Summit On Translational Science. 2013: 156-7. PMID 24303327  0.411
2013 Chang LW, Viader A, Varghese N, Payton JE, Milbrandt J, Nagarajan R. An integrated approach to characterize transcription factor and microRNA regulatory networks involved in Schwann cell response to peripheral nerve injury. Bmc Genomics. 14: 84. PMID 23387820 DOI: 10.1186/1471-2164-14-84  0.752
2013 Hagemann IS, Al-Kateb H, Cottrell CE, Lockwood C, Nguyen T, Spencer D, Bredemeyer A, Head R, Varghese N, Nagarajan R, Seibert K, Duncavage EJ, Kulkarni S, Pfeifer JD. Abstract 813: Diagnostic yield of targeted next-generation sequencing for personalized cancer therapeutics. Cancer Research. 73: 813-813. DOI: 10.1158/1538-7445.Am2013-813  0.306
2012 Wartman LD, Welch JS, Uy GL, Klco JM, Lamprecht T, Varghese N, Nagarajan R, Ley TJ. Expression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA mice. Plos One. 7: e46529. PMID 23056333 DOI: 10.1371/Journal.Pone.0046529  0.388
2012 Hucthagowder V, Meyer R, Mullins C, Nagarajan R, DiPersio JF, Vij R, Tomasson MH, Kulkarni S. Resequencing analysis of the candidate tyrosine kinase and RAS pathway gene families in multiple myeloma. Cancer Genetics. 205: 474-8. PMID 22939401 DOI: 10.1016/J.Cancergen.2012.06.007  0.354
2012 Welch JS, Ley TJ, Link DC, Miller CA, Larson DE, Koboldt DC, Wartman LD, Lamprecht TL, Liu F, Xia J, Kandoth C, Fulton RS, McLellan MD, Dooling DJ, Wallis JW, ... ... Nagarajan R, et al. The origin and evolution of mutations in acute myeloid leukemia. Cell. 150: 264-78. PMID 22817890 DOI: 10.1016/J.Cell.2012.06.023  0.327
2011 Viader A, Chang LW, Fahrner T, Nagarajan R, Milbrandt J. MicroRNAs modulate Schwann cell response to nerve injury by reinforcing transcriptional silencing of dedifferentiation-related genes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 17358-69. PMID 22131398 DOI: 10.1523/Jneurosci.3931-11.2011  0.744
2011 Deshmukh H, Yu J, Shaik J, MacDonald TJ, Perry A, Payton JE, Gutmann DH, Watson MA, Nagarajan R. Identification of transcriptional regulatory networks specific to pilocytic astrocytoma. Bmc Medical Genomics. 4: 57. PMID 21745356 DOI: 10.1186/1755-8794-4-57  0.396
2011 Link DC, Schuettpelz LG, Shen D, Wang J, Walter MJ, Kulkarni S, Payton JE, Ivanovich J, Goodfellow PJ, Le Beau M, Koboldt DC, Dooling DJ, Fulton RS, Bender RH, Fulton LL, ... ... Nagarajan R, et al. Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML. Jama. 305: 1568-76. PMID 21505135 DOI: 10.1001/Jama.2011.473  0.337
2011 Jones EA, Lopez-Anido C, Srinivasan R, Krueger C, Chang LW, Nagarajan R, Svaren J. Regulation of the PMP22 gene through an intronic enhancer. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 4242-50. PMID 21411665 DOI: 10.1523/Jneurosci.5893-10.2011  0.477
2011 Yu J, Deshmukh H, Payton JE, Dunham C, Scheithauer BW, Tihan T, Prayson RA, Guha A, Bridge JA, Ferner RE, Lindberg GM, Gutmann RJ, Emnett RJ, Salavaggione L, Gutmann DH, ... Nagarajan R, et al. Array-based comparative genomic hybridization identifies CDK4 and FOXM1 alterations as independent predictors of survival in malignant peripheral nerve sheath tumor. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 1924-34. PMID 21325289 DOI: 10.1158/1078-0432.Ccr-10-1551  0.376
2011 Welch JS, Klco JM, Varghese N, Nagarajan R, Ley TJ. Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice. Blood. 117: 2460-8. PMID 21190992 DOI: 10.1182/Blood-2010-08-300087  0.318
2011 Welch JS, Larson D, Ding L, McLellan MD, Lamprecht T, Kandoth C, Payton JE, Baty J, Harris CC, Lichti CF, Fulton RS, Dooling DJ, Koboldt DC, Schmidt H, Zhang Q, ... ... Nagarajan R, et al. Complete Sequencing and Comparison of 12 Normal Karyotype M1 AML Genomes with 12 t(15;17) Positive M3-APL Genomes Blood. 118: 404-404. DOI: 10.1182/Blood.V118.21.404.404  0.354
2010 Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Payton JE, Baty J, Welch J, Harris CC, Lichti CF, Townsend RR, Fulton RS, Dooling DJ, ... ... Nagarajan R, et al. DNMT3A mutations in acute myeloid leukemia. The New England Journal of Medicine. 363: 2424-33. PMID 21067377 DOI: 10.1056/Nejmoa1005143  0.311
2010 Jang SW, Srinivasan R, Jones EA, Sun G, Keles S, Krueger C, Chang LW, Nagarajan R, Svaren J. Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes. Journal of Neurochemistry. 115: 1409-20. PMID 21044070 DOI: 10.1111/J.1471-4159.2010.07045.X  0.486
2010 Fehniger TA, Wylie T, Germino E, Leong JW, Magrini VJ, Koul S, Keppel CR, Schneider SE, Koboldt DC, Sullivan RP, Heinz ME, Crosby SD, Nagarajan R, Ramsingh G, Link DC, et al. Next-generation sequencing identifies the natural killer cell microRNA transcriptome. Genome Research. 20: 1590-604. PMID 20935160 DOI: 10.1101/Gr.107995.110  0.321
2010 Ramsingh G, Koboldt DC, Trissal M, Chiappinelli KB, Wylie T, Koul S, Chang LW, Nagarajan R, Fehniger TA, Goodfellow P, Magrini V, Wilson RK, Ding L, Ley TJ, Mardis ER, et al. Complete characterization of the microRNAome in a patient with acute myeloid leukemia. Blood. 116: 5316-26. PMID 20876853 DOI: 10.1182/Blood-2010-05-285395  0.384
2010 Wentz AE, d'Avignon DA, Weber ML, Cotter DG, Doherty JM, Kerns R, Nagarajan R, Reddy N, Sambandam N, Crawford PA. Adaptation of myocardial substrate metabolism to a ketogenic nutrient environment. The Journal of Biological Chemistry. 285: 24447-56. PMID 20529848 DOI: 10.1074/Jbc.M110.100651  0.559
2010 Ramsingh G, Koboldt D, Magrini V, Trissal M, Koul S, Chang L, Nagarajan R, Ley TJ, Mardis E, Link DC. Characterization of the microRNAome in a patient with acute myeloid leukemia. Journal of Clinical Oncology. 28: 10501-10501. DOI: 10.1200/Jco.2010.28.15_Suppl.10501  0.348
2010 Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Payton JE, Baty J, Welch JS, Harris CC, Lichti CF, Townsend RR, Fulton RS, Dooling DJ, ... ... Nagarajan R, et al. Mutations In the DNA Methyltransferase Gene DNMT3A Are Highly Recurrent In Patients with Intermediate Risk Acute Myeloid Leukemia, and Predict Poor Outcomes Blood. 116: 99-99. DOI: 10.1182/Blood.V116.21.99.99  0.349
2010 Schuettpelz L, Link DC, Shen D, Walter MJ, Koboldt DC, Dooling DJ, Fulton RS, Schmidt H, Maupin R, O'Laughlin M, Chen K, McLellan MD, Kulkarni S, Ivanovich J, Lebeau M, ... ... Nagarajan R, et al. DNA Sequence of the Cancer Genome of a Patient with Therapy-Related Acute Myeloid Leukemia Blood. 116: 580-580. DOI: 10.1182/Blood.V116.21.580.580  0.343
2010 Fehniger TA, Wylie T, Germino E, Leong JW, Magrini VJ, Koul S, Keppel CR, Schneider SE, Koboldt DC, Sullivan RP, Heinz ME, Crosby SD, Nagarajan R, Ramsingh G, Link DC, et al. The NK Cell MicroRNA Transcriptome Defined by Next-Generation Sequencing Identifies IL-15-Signaled Alterations In Mature MiR-223 Expression, and MiR-223 as a Potential Regulator of Murine Granzyme B Blood. 116: 104-104. DOI: 10.1182/Blood.V116.21.104.104  0.303
2010 Ramsingh G, Koboldt DC, Trissal M, Chiappinelli KB, Wylie T, Koul S, Chang L, Nagarajan R, Fehniger TA, Goodfellow P, Magrini V, Wilson RK, Ding L, Ley TJ, Mardis ER, et al. Abstract B12: Complete characterization of the “microRNAome” of a human acute myeloid leukemia Clinical Cancer Research. 16. DOI: 10.1158/1078-0432.Tcmusa10-B12  0.352
2009 Yu J, Deshmukh H, Gutmann RJ, Emnett RJ, Rodriguez FJ, Watson MA, Nagarajan R, Gutmann DH. Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma. Neurology. 73: 1526-31. PMID 19794125 DOI: 10.1212/Wnl.0B013E3181C0664A  0.322
2009 Mardis ER, Ding L, Dooling DJ, Larson DE, McLellan MD, Chen K, Koboldt DC, Fulton RS, Delehaunty KD, McGrath SD, Fulton LA, Locke DP, Magrini VJ, Abbott RM, Vickery TL, ... ... Nagarajan R, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. The New England Journal of Medicine. 361: 1058-66. PMID 19657110 DOI: 10.1056/Nejmoa0903840  0.346
2009 Walter MJ, Payton JE, Ries RE, Shannon WD, Deshmukh H, Zhao Y, Baty J, Heath S, Westervelt P, Watson MA, Tomasson MH, Nagarajan R, O'Gara BP, Bloomfield CD, Mrózek K, et al. Acquired copy number alterations in adult acute myeloid leukemia genomes. Proceedings of the National Academy of Sciences of the United States of America. 106: 12950-5. PMID 19651600 DOI: 10.1073/Pnas.0903091106  0.327
2009 Payton JE, Grieselhuber NR, Chang LW, Murakami M, Geiss GK, Link DC, Nagarajan R, Watson MA, Ley TJ. High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples. The Journal of Clinical Investigation. 119: 1714-26. PMID 19451695 DOI: 10.1172/Jci38248  0.383
2009 Baloh RH, Strickland A, Ryu E, Le N, Fahrner T, Yang M, Nagarajan R, Milbrandt J. Congenital hypomyelinating neuropathy with lethal conduction failure in mice carrying the Egr2 I268N mutation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 2312-21. PMID 19244508 DOI: 10.1523/Jneurosci.2168-08.2009  0.758
2009 Ramsingh G, Koboldt DC, Fehniger TA, Wylie T, Magrini V, Trissal M, Koul S, Chang L, Nagarajan R, Ley TJ, Mardis E, Link DC. Comprehensive Evaluation of MicroRNA Genes and Gene Expression Using Next Generation Sequencing in a Patient with Acute Myelogenous Leukemia. Blood. 114: 271-271. DOI: 10.1182/Blood.V114.22.271.271  0.363
2009 Grieselhuber NR, Shaik JS, Chang L, McGrath S, Wartman LD, Nagarajan R, Wilson RK, Mardis E, Ley TJ. Chromatin Immunoprecipitation of GFP-Tagged PML-Rara Coupled to High-Throughput Next Generation Sequencing. Blood. 114: 1276-1276. DOI: 10.1182/Blood.V114.22.1276.1276  0.376
2008 Ley TJ, Mardis ER, Ding L, Fulton B, McLellan MD, Chen K, Dooling D, Dunford-Shore BH, McGrath S, Hickenbotham M, Cook L, Abbott R, Larson DE, Koboldt DC, Pohl C, ... ... Nagarajan R, et al. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature. 456: 66-72. PMID 18987736 DOI: 10.1038/Nature07485  0.37
2008 Ryu EJ, Yang M, Gustin JA, Chang LW, Freimuth RR, Nagarajan R, Milbrandt J. Analysis of peripheral nerve expression profiles identifies a novel myelin glycoprotein, MP11. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 7563-73. PMID 18650334 DOI: 10.1523/Jneurosci.1659-08.2008  0.62
2008 Deshmukh H, Yeh TH, Yu J, Sharma MK, Perry A, Leonard JR, Watson MA, Gutmann DH, Nagarajan R. High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas. Oncogene. 27: 4745-51. PMID 18408760 DOI: 10.1038/Onc.2008.110  0.309
2008 Chang LW, Payton JE, Yuan W, Ley TJ, Nagarajan R, Stormo GD. Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia. Genome Biology. 9: R38. PMID 18291030 DOI: 10.1186/Gb-2008-9-2-R38  0.364
2008 Tomasson MH, Xiang Z, Walgren R, Zhao Y, Kasai Y, Miner T, Ries RE, Lubman O, Fremont DH, McLellan MD, Payton JE, Westervelt P, DiPersio JF, Link DC, Walter MJ, ... ... Nagarajan R, et al. Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia. Blood. 111: 4797-808. PMID 18270328 DOI: 10.1182/Blood-2007-09-113027  0.39
2008 Xiang Z, Zhao Y, Mitaksov V, Fremont DH, Kasai Y, Molitoris A, Ries RE, Miner TL, McLellan MD, DiPersio JF, Link DC, Payton JE, Graubert TA, Watson M, Shannon W, ... ... Nagarajan R, et al. Identification of somatic JAK1 mutations in patients with acute myeloid leukemia. Blood. 111: 4809-12. PMID 18160671 DOI: 10.1182/Blood-2007-05-090308  0.346
2007 Jones EA, Jang SW, Mager GM, Chang LW, Srinivasan R, Gokey NG, Ward RM, Nagarajan R, Svaren J. Interactions of Sox10 and Egr2 in myelin gene regulation. Neuron Glia Biology. 3: 377-87. PMID 18634568 DOI: 10.1017/S1740925X08000173  0.471
2007 Ellis MJ, Dixon M, Dowsett M, Nagarajan R, Mardis E. A luminal breast cancer genome atlas: progress and barriers. The Journal of Steroid Biochemistry and Molecular Biology. 106: 125-9. PMID 17826627 DOI: 10.1016/J.Jsbmb.2007.05.011  0.307
2007 Chang LW, Fontaine BR, Stormo GD, Nagarajan R. PAP: a comprehensive workbench for mammalian transcriptional regulatory sequence analysis. Nucleic Acids Research. 35: W238-44. PMID 17517777 DOI: 10.1093/Nar/Gkm308  0.385
2007 Link DC, Kunter G, Kasai Y, Zhao Y, Miner T, McLellan MD, Ries RE, Kapur D, Nagarajan R, Dale DC, Bolyard AA, Boxer LA, Welte K, Zeidler C, Donadieu J, et al. Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia. Blood. 110: 1648-55. PMID 17494858 DOI: 10.1182/Blood-2007-03-081216  0.353
2007 Sharma MK, Mansur DB, Reifenberger G, Perry A, Leonard JR, Aldape KD, Albin MG, Emnett RJ, Loeser S, Watson MA, Nagarajan R, Gutmann DH. Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin. Cancer Research. 67: 890-900. PMID 17283119 DOI: 10.1158/0008-5472.Can-06-0973  0.349
2007 Payton JE, Grieselhuber NR, Chang L, Murakami MA, Yuan W, Link DC, Nagarajan R, Watson MA, Ley TJ. The Expression Signature of M3 AML Suggests Direct and Indirect Effects of PML-RARA on Target Genes. Blood. 110: 719-719. DOI: 10.1182/Blood.V110.11.719.719  0.305
2006 Chang LW, Nagarajan R, Magee JA, Milbrandt J, Stormo GD. A systematic model to predict transcriptional regulatory mechanisms based on overrepresentation of transcription factor binding profiles. Genome Research. 16: 405-13. PMID 16449500 DOI: 10.1101/Gr.4303406  0.723
2005 Le N, Nagarajan R, Wang JY, Svaren J, LaPash C, Araki T, Schmidt RE, Milbrandt J. Nab proteins are essential for peripheral nervous system myelination. Nature Neuroscience. 8: 932-40. PMID 16136673 DOI: 10.1038/Nn1490  0.741
2005 Le N, Nagarajan R, Wang JY, Araki T, Schmidt RE, Milbrandt J. Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination. Proceedings of the National Academy of Sciences of the United States of America. 102: 2596-601. PMID 15695336 DOI: 10.1073/Pnas.0407836102  0.752
2004 Walter MJ, Park JS, Lau SK, Li X, Lane AA, Nagarajan R, Shannon WD, Ley TJ. Expression profiling of murine acute promyelocytic leukemia cells reveals multiple model-dependent progression signatures. Molecular and Cellular Biology. 24: 10882-93. PMID 15572690 DOI: 10.1128/Mcb.24.24.10882-10893.2004  0.381
2003 Young AP, Nagarajan R, Longmore GD. Mechanisms of transcriptional regulation by Rb-E2F segregate by biological pathway. Oncogene. 22: 7209-17. PMID 14562049 DOI: 10.1038/Sj.Onc.1206804  0.368
2002 Modur V, Nagarajan R, Evers BM, Milbrandt J. FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer. The Journal of Biological Chemistry. 277: 47928-37. PMID 12351634 DOI: 10.1074/Jbc.M207509200  0.521
2002 Nagarajan R, Le N, Mahoney H, Araki T, Milbrandt J. Deciphering peripheral nerve myelination by using Schwann cell expression profiling. Proceedings of the National Academy of Sciences of the United States of America. 99: 8998-9003. PMID 12084938 DOI: 10.1073/Pnas.132080999  0.742
2001 Araki T, Nagarajan R, Milbrandt J. Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery. The Journal of Biological Chemistry. 276: 34131-41. PMID 11427537 DOI: 10.1074/Jbc.M104271200  0.613
2001 Nagarajan R, Svaren J, Le N, Araki T, Watson M, Milbrandt J. EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression. Neuron. 30: 355-68. PMID 11394999 DOI: 10.1016/S0896-6273(01)00282-3  0.755
2000 Tourtellotte WG, Nagarajan R, Bartke A, Milbrandt J. Functional compensation by Egr4 in Egr1-dependent luteinizing hormone regulation and Leydig cell steroidogenesis. Molecular and Cellular Biology. 20: 5261-8. PMID 10866682 DOI: 10.1128/Mcb.20.14.5261-5268.2000  0.511
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