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Peng Gong, Ph.D. - Publications

Affiliations: 
University of Massachusetts, Amherst, Amherst, MA 
Area:
transcription, rna
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49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Wang X, Jing X, Shi J, Liu Q, Shen S, Cheung PP, Wu J, Deng F, Gong P. A jingmenvirus RNA-dependent RNA polymerase structurally resembles the flavivirus counterpart but with different features at the initiation phase. Nucleic Acids Research. PMID 38296832 DOI: 10.1093/nar/gkae042  0.386
2023 Tan Z, Wu J, Huang L, Wang T, Zheng Z, Zhang J, Ke X, Zhang Y, Liu Y, Wang H, Tao J, Gong P. LGP2 directly interacts with flavivirus NS5 RNA-dependent RNA polymerase and downregulates its pre-elongation activities. Plos Pathogens. 19: e1011620. PMID 37656756 DOI: 10.1371/journal.ppat.1011620  0.389
2023 Fang X, Lu G, Deng Y, Yang S, Hou C, Gong P. Unusual substructure conformations observed in crystal structures of a dicistrovirus RNA-dependent RNA polymerase suggest contribution of the N-terminal extension in proper folding. Virologica Sinica. PMID 37156298 DOI: 10.1016/j.virs.2023.05.002  0.332
2022 Wu J, Wang X, Liu Q, Lu G, Gong P. Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases. Proceedings of the National Academy of Sciences of the United States of America. 120: e2211425120. PMID 36577062 DOI: 10.1073/pnas.2211425120  0.433
2022 Li R, Wang M, Gong P. Crystal structure of a pre-chemistry viral RNA-dependent RNA polymerase suggests participation of two basic residues in catalysis. Nucleic Acids Research. PMID 36477355 DOI: 10.1093/nar/gkac1133  0.309
2022 Chen S, Wu J, Yang X, Sun Q, Liu S, Rashid F, Dzakah EE, Wang H, Wang J, Gong P, Tang S. RNA-Dependent RNA Polymerase of the Second Human Pegivirus Exhibits a High-Fidelity Feature. Microbiology Spectrum. e0272922. PMID 35980196 DOI: 10.1128/spectrum.02729-22  0.319
2022 Hao H, Liu W, Miao Y, Ma L, Yu B, Liu L, Yang C, Zhang K, Chen Z, Yang J, Zheng Z, Zhang B, Deng F, Gong P, Yuan J, et al. N4-acetylcytidine regulates the replication and pathogenicity of enterovirus 71. Nucleic Acids Research. PMID 35971620 DOI: 10.1093/nar/gkac675  0.416
2022 Liu Q, Wu J, Gong P. Assessment of nucleotide/nucleoside analog intervention in primer-dependent viral RNA-dependent RNA polymerases. Star Protocols. 3: 101468. PMID 35761985 DOI: 10.1016/j.xpro.2022.101468  0.351
2022 Jia H, Zhong Y, Peng C, Gong P. Crystal Structures of Flavivirus NS5 Guanylyltransferase Reveal a GMP-Arginine Adduct. Journal of Virology. e0041822. PMID 35758665 DOI: 10.1128/jvi.00418-22  0.366
2021 Gong P. Within and Beyond the Nucleotide Addition Cycle of Viral RNA-dependent RNA Polymerases. Frontiers in Molecular Biosciences. 8: 822218. PMID 35083282 DOI: 10.3389/fmolb.2021.822218  0.432
2021 Gong P. Structural basis of viral RNA-dependent RNA polymerase nucleotide addition cycle in picornaviruses. The Enzymes. 49: 215-233. PMID 34696833 DOI: 10.1016/bs.enz.2021.06.002  0.452
2021 Wu J, Wang H, Liu Q, Li R, Gao Y, Fang X, Zhong Y, Wang M, Wang Q, Rao Z, Gong P. Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complex. Cell Reports. 109882. PMID 34653416 DOI: 10.1016/j.celrep.2021.109882  0.373
2021 Zhang BY, Liu W, Jia H, Lu G, Gong P. An induced-fit de novo initiation mechanism suggested by a pestivirus RNA-dependent RNA polymerase. Nucleic Acids Research. PMID 34365500 DOI: 10.1093/nar/gkab666  0.44
2021 Yang J, Jing X, Yi W, Li XD, Yao C, Zhang B, Zheng Z, Wang H, Gong P. Crystal structure of a tick-borne flavivirus RNA-dependent RNA polymerase suggests a host adaptation hotspot in RNA viruses. Nucleic Acids Research. PMID 33406260 DOI: 10.1093/nar/gkaa1250  0.347
2020 Wu L, Jin D, Wang D, Jing X, Gong P, Qin Y, Chen M. The two-stage interaction of Ebola virus VP40 with nucleoprotein results in a switch from viral RNA synthesis to virion assembly/budding. Protein & Cell. PMID 33141416 DOI: 10.1007/s13238-020-00764-0  0.305
2020 Wang Q, Wu J, Wang H, Gao Y, Liu Q, Mu A, Ji W, Yan L, Zhu Y, Zhu C, Fang X, Yang X, Huang Y, Gao H, Liu F, ... ... Gong P, et al. Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase. Cell. PMID 32526208 DOI: 10.1016/J.Cell.2020.05.034  0.519
2020 Wang M, Li R, Shu B, Jing X, Ye HQ, Gong P. Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures. Nature Communications. 11: 2605. PMID 32451382 DOI: 10.1038/s41467-020-16234-4  0.442
2020 Wu J, Ye HQ, Zhang QY, Lu G, Zhang B, Gong P. A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase. Plos Pathogens. 16: e1008484. PMID 32357182 DOI: 10.1371/Journal.Ppat.1008484  0.304
2020 Zhang QY, Li XF, Niu X, Li N, Wang HJ, Deng CL, Ye HQ, Huang XY, Chen Q, Xu YP, Dong HL, Li XD, Zhao H, Shi PY, Yuan ZM, ... Gong P, et al. Short direct repeats in the 3'-untranslated region are involved in subgenomic flaviviral RNA production. Journal of Virology. PMID 31896596 DOI: 10.1128/Jvi.01175-19  0.411
2019 Shi W, Ye HQ, Deng CL, Li R, Zhang B, Gong P. A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability. Nucleic Acids Research. PMID 31863580 DOI: 10.1093/Nar/Gkz1170  0.417
2019 Jia H, Gong P. A Structure-Function Diversity Survey of the RNA-Dependent RNA Polymerases From the Positive-Strand RNA Viruses. Frontiers in Microbiology. 10: 1945. PMID 31507560 DOI: 10.3389/fmicb.2019.01945  0.4
2018 Liu W, Shi X, Gong P. A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Research. PMID 30239956 DOI: 10.1093/nar/gky848  0.41
2018 Zheng Z, Yang J, Jiang X, Liu Y, Zhang X, Li M, Zhang M, Fu M, Hu K, Wang H, Luo MH, Gong P, Hu Q. Tick-Borne Encephalitis Virus Nonstructural Protein NS5 Induces RANTES Expression Dependent on the RNA-Dependent RNA Polymerase Activity. Journal of Immunology (Baltimore, Md. : 1950). PMID 29760190 DOI: 10.4049/Jimmunol.1701507  0.427
2018 Wu J, Gong P. Visualizing the Nucleotide Addition Cycle of Viral RNA-Dependent RNA Polymerase. Viruses. 10. PMID 29300357 DOI: 10.3390/v10010024  0.407
2017 Bi P, Shu B, Gong P. Crystal structure of the coxsackievirus A16 RNA-dependent RNA polymerase elongation complex reveals novel features in motif A dynamics. Virologica Sinica. PMID 29164396 DOI: 10.1007/s12250-017-4066-8  0.397
2017 Zheng F, Lu G, Li L, Gong P, Pan Z. The uncoupling of protease trans-cleavage and helicase activities in the pestivirus NS3. Journal of Virology. PMID 28835495 DOI: 10.1128/JVI.01094-17  0.323
2017 Shi W, Gong P. A practical approach to generate suitable de novo synthesis RNA template for a flavivirus RNA-dependent RNA polymerase. Virologica Sinica. PMID 28646484 DOI: 10.1007/s12250-017-4003-x  0.405
2017 Shu B, Gong P. The uncoupling of catalysis and translocation in the viral RNA-dependent RNA polymerase. Rna Biology. 0. PMID 28277928 DOI: 10.1080/15476286.2017.1300221  0.453
2017 Lu G, Gong P. A structural view of the RNA-dependent RNA polymerases from the Flavivirus genus. Virus Research. PMID 28131854 DOI: 10.1016/J.Virusres.2017.01.020  0.512
2016 Liu Y, Zheng Z, Shu B, Meng J, Zhang Y, Zheng C, Ke X, Gong P, Hu Q, Wang H. SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D to Facilitate Viral Replication. Journal of Virology. PMID 27630238 DOI: 10.1128/Jvi.01756-16  0.384
2016 Wang SR, Zhang QY, Wang JQ, Ge XY, Song YY, Wang YF, Li XD, Fu BS, Xu GH, Shu B, Gong P, Zhang B, Tian T, Zhou X. Chemical Targeting of a G-Quadruplex RNA in the Ebola Virus L Gene. Cell Chemical Biology. PMID 27617851 DOI: 10.1016/J.Chembiol.2016.07.019  0.435
2016 Shu B, Gong P. Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27339134 DOI: 10.1073/Pnas.1602591113  0.512
2015 Wu J, Liu W, Gong P. A Structural Overview of RNA-Dependent RNA Polymerases from the Flaviviridae Family. International Journal of Molecular Sciences. 16: 12943-12957. PMID 26062131 DOI: 10.3390/ijms160612943  0.449
2015 Chen L, Yan Q, Lu G, Hu Z, Zhang G, Zhang S, Ding B, Jiang Y, Zhong Y, Gong P, Chen M. Several residues within the N-terminal arm of vesicular stomatitis virus nucleoprotein play a critical role in protecting viral RNA from nuclease digestion. Virology. 478: 9-17. PMID 25682471 DOI: 10.1016/j.virol.2015.01.021  0.357
2015 Wu J, Lu G, Zhang B, Gong P. Perturbation in the conserved methyltransferase-polymerase interface of flavivirus NS5 differentially affects polymerase initiation and elongation. Journal of Virology. 89: 249-61. PMID 25320292 DOI: 10.1128/Jvi.02085-14  0.517
2014 Shang L, Wang Y, Qing J, Shu B, Cao L, Lou Z, Gong P, Sun Y, Yin Z. An adenosine nucleoside analogue NITD008 inhibits EV71 proliferation. Antiviral Research. 112: 47-58. PMID 25446894 DOI: 10.1016/J.Antiviral.2014.10.009  0.382
2014 Li XD, Shan C, Deng CL, Ye HQ, Shi PY, Yuan ZM, Gong P, Zhang B. The interface between methyltransferase and polymerase of NS5 is essential for flavivirus replication. Plos Neglected Tropical Diseases. 8: e2891. PMID 24852307 DOI: 10.1371/Journal.Pntd.0002891  0.446
2014 Deng Z, Lehmann KC, Li X, Feng C, Wang G, Zhang Q, Qi X, Yu L, Zhang X, Feng W, Wu W, Gong P, Tao Y, Posthuma CC, Snijder EJ, et al. Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase. Nucleic Acids Research. 42: 3464-77. PMID 24369429 DOI: 10.1093/Nar/Gkt1310  0.39
2013 Lu G, Gong P. Crystal Structure of the full-length Japanese encephalitis virus NS5 reveals a conserved methyltransferase-polymerase interface. Plos Pathogens. 9: e1003549. PMID 23950717 DOI: 10.1371/Journal.Ppat.1003549  0.446
2013 Gong P, Kortus MG, Nix JC, Davis RE, Peersen OB. Structures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contacts. Plos One. 8: e60272. PMID 23667424 DOI: 10.1371/Journal.Pone.0060272  0.527
2012 Gnädig NF, Beaucourt S, Campagnola G, Bordería AV, Sanz-Ramos M, Gong P, Blanc H, Peersen OB, Vignuzzi M. Coxsackievirus B3 mutator strains are attenuated in vivo. Proceedings of the National Academy of Sciences of the United States of America. 109: E2294-303. PMID 22853955 DOI: 10.1073/Pnas.1204022109  0.355
2011 Campagnola G, Gong P, Peersen OB. High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. Antiviral Research. 91: 241-51. PMID 21722674 DOI: 10.1016/J.Antiviral.2011.06.006  0.503
2010 Gong P, Peersen OB. Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase. Proceedings of the National Academy of Sciences of the United States of America. 107: 22505-10. PMID 21148772 DOI: 10.1073/Pnas.1007626107  0.518
2009 Murphy MN, Gong P, Ralto K, Manelyte L, Savery NJ, Theis K. An N-terminal clamp restrains the motor domains of the bacterial transcription-repair coupling factor Mfd. Nucleic Acids Research. 37: 6042-53. PMID 19700770 DOI: 10.1093/Nar/Gkp680  0.325
2009 Gong P, Campagnola G, Peersen OB. A quantitative stopped-flow fluorescence assay for measuring polymerase elongation rates. Analytical Biochemistry. 391: 45-55. PMID 19406094 DOI: 10.1016/J.Ab.2009.04.035  0.404
2006 Gong P, Martin CT. Mechanism of instability in abortive cycling by T7 RNA polymerase. The Journal of Biological Chemistry. 281: 23533-44. PMID 16790422 DOI: 10.1074/Jbc.M604023200  0.657
2005 Martin CT, Esposito EA, Theis K, Gong P. Structure and function in promoter escape by T7 RNA polymerase. Progress in Nucleic Acid Research and Molecular Biology. 80: 323-47. PMID 16164978 DOI: 10.1016/S0079-6603(05)80008-X  0.704
2004 Theis K, Gong P, Martin CT. Topological and conformational analysis of the initiation and elongation complex of t7 RNA polymerase suggests a new twist. Biochemistry. 43: 12709-15. PMID 15461442 DOI: 10.1021/Bi0486987  0.576
2004 Gong P, Esposito EA, Martin CT. Initial bubble collapse plays a key role in the transition to elongation in T7 RNA polymerase. The Journal of Biological Chemistry. 279: 44277-85. PMID 15337752 DOI: 10.1074/Jbc.M409118200  0.702
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