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David V. Smil, Ph.D. - Publications

Affiliations: 
University of Toronto, Toronto, ON, Canada 
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40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Smil D, Wong JF, Williams E, Adamson R, Howarth A, McLeod D, Mamai A, Kim S, Wilson B, Kiyota T, Aman A, Owen J, Poda G, Horiuchi K, Kuznetsova E, et al. Leveraging an Open Science Drug Discovery Model to Develop CNS Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma. Journal of Medicinal Chemistry. PMID 32787083 DOI: 10.1021/Acs.Jmedchem.0C01199  0.323
2020 Ensan D, Smil D, Zepeda-Velázquez CA, Panagopoulos D, Wong JF, Williams EP, Adamson R, Bullock AN, Kiyota T, Aman A, Roberts OG, Edwards AM, O'Meara JA, Isaac MB, Al-Awar R. Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma. Journal of Medicinal Chemistry. PMID 32369358 DOI: 10.1021/Acs.Jmedchem.0C00395  0.314
2019 Mader P, Mendoza-Sanchez R, Iqbal A, Dong A, Dobrovetsky E, Corless VB, Liew SK, Houliston SR, De Freitas RF, Smil D, Sena CCD, Kennedy S, Diaz DB, Wu H, Dombrovski L, et al. Identification and characterization of the first fragment hits for SETDB1 Tudor domain. Bioorganic & Medicinal Chemistry. PMID 31327677 DOI: 10.1016/J.Bmc.2019.07.020  0.31
2017 Kaniskan HÜ, Eram MS, Zhao K, Szewczyk MM, Yang X, Schmidt K, Luo X, Xiao S, Dai M, He F, Zang I, Lin Y, Li F, Dobrovetsky E, Smil D, et al. Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3). Journal of Medicinal Chemistry. PMID 29244490 DOI: 10.1021/Acs.Jmedchem.7B01674  0.392
2016 Kaniskan HÜ, Eram MS, Liu J, Smil D, Martini ML, Shen Y, Santhakumar V, Brown PJ, Arrowsmith C, Vedadi M, Jin J. Design and synthesis of selective, small molecule inhibitors of coactivator-associated arginine methyltransferase 1 (CARM1). Medchemcomm. 7: 1793-1796. PMID 28042453 DOI: 10.1039/C6Md00342G  0.36
2016 Hughes SJ, Barnard L, Mottaghi K, Tempel W, Antoshchenko T, Hong BS, Allali-Hassani A, Smil D, Vedadi M, Strauss E, Park HW. Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product. Acs Infectious Diseases. 2: 627-641. PMID 27759386 DOI: 10.1021/Acsinfecdis.6B00090  0.354
2016 Shen Y, Szewczyk MM, Eram MS, Smil D, Kaniskan HÜ, de Freitas RF, Senisterra G, Li F, Schapira M, Brown PJ, Arrowsmith CH, Barsyte-Lovejoy D, Liu J, Vedadi M, Jin J. Discovery of a Potent, Selective and Cell-active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. Journal of Medicinal Chemistry. PMID 27584694 DOI: 10.1021/Acs.Jmedchem.6B01033  0.353
2016 Ferreira de Freitas R, Eram MS, Smil D, Szewczyk MM, Kennedy S, Brown PJ, Santhakumar V, Barsyte-Lovejoy D, Arrowsmith CH, Vedadi M, Schapira M. Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening. Journal of Medicinal Chemistry. PMID 27390919 DOI: 10.1021/Acs.Jmedchem.6B00668  0.323
2016 Gilan O, Lam EY, Becher I, Lugo D, Cannizzaro E, Joberty G, Ward A, Wiese M, Fong CY, Ftouni S, Tyler D, Stanley K, MacPherson L, Weng CF, Chan YC, ... ... Smil D, et al. Functional interdependence of BRD4 and DOT1L in MLL leukemia. Nature Structural & Molecular Biology. PMID 27294782 DOI: 10.1038/Nsmb.3249  0.308
2016 Getlik M, Smil D, Zepeda-Velázquez C, Bolshan Y, Poda G, Wu H, Dong A, Kuznetsova E, Marcellus R, Senisterra G, Dombrovski L, Hajian T, Kiyota T, Schapira M, Arrowsmith CH, et al. Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). Journal of Medicinal Chemistry. PMID 26958703 DOI: 10.1021/Acs.Jmedchem.5B01630  0.744
2016 Ferreira de Freitas R, Eram MS, Szewczyk MM, Steuber H, Smil D, Wu H, Li F, Senisterra G, Dong A, Brown PJ, Hitchcock M, Moosmayer D, Stegmann CM, Egner U, Arrowsmith C, et al. Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor. Journal of Medicinal Chemistry. PMID 26824386 DOI: 10.1021/Acs.Jmedchem.5B01772  0.363
2015 Davydov R, Strushkevich N, Smil D, Yantsevich A, Gilep A, Usanov S, Hoffman BM. Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies. Biochemistry. PMID 26603348 DOI: 10.1021/Acs.Biochem.5B00903  0.346
2015 Grebien F, Vedadi M, Getlik M, Giambruno R, Grover A, Avellino R, Skucha A, Vittori S, Kuznetsova E, Smil D, Barsyte-Lovejoy D, Li F, Poda G, Schapira M, Wu H, et al. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nature Chemical Biology. 11: 571-8. PMID 26167872 DOI: 10.1038/Nchembio.1859  0.313
2015 Smil D, Eram MS, Li F, Kennedy S, Szewczyk MM, Brown PJ, Barsyte-Lovejoy D, Arrowsmith CH, Vedadi M, Schapira M. Discovery of a Dual PRMT5-PRMT7 Inhibitor. Acs Medicinal Chemistry Letters. 6: 408-12. PMID 25893041 DOI: 10.1021/Ml500467H  0.353
2015 Kaniskan HÜ, Szewczyk MM, Yu Z, Eram MS, Yang X, Schmidt K, Luo X, Dai M, He F, Zang I, Lin Y, Kennedy S, Li F, Dobrovetsky E, Dong A, ... Smil D, et al. A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angewandte Chemie (International Ed. in English). 54: 5166-70. PMID 25728001 DOI: 10.1002/Anie.201412154  0.359
2014 Hughes SJ, Antoshchenko T, Kim KP, Smil D, Park HW. Structural characterization of a new N-substituted pantothenamide bound to pantothenate kinases from Klebsiella pneumoniae and Staphylococcus aureus. Proteins. 82: 1542-8. PMID 24470271 DOI: 10.1002/Prot.24524  0.321
2014 Al-Awar R, Al-Awar R, Getlik M, Smil D, Bolshan Y, Poda G, Senisterra G, Wu H, Allali-Hassani A, Wasney G, Barsyte-Lovejoy D, Dombrovski L, Dong A, He H, Seitova A, et al. 287 The discovery and optimization of small molecule antagonists of the WDR5–MLL interaction European Journal of Cancer. 50: 95. DOI: 10.1016/S0959-8049(14)70413-7  0.698
2013 Bolshan Y, Getlik M, Kuznetsova E, Wasney GA, Hajian T, Poda G, Nguyen KT, Wu H, Dombrovski L, Dong A, Senisterra G, Schapira M, Arrowsmith CH, Brown PJ, Al-Awar R, ... ... Smil D, et al. Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction. Acs Medicinal Chemistry Letters. 4: 353-7. PMID 24900672 DOI: 10.1021/Ml300467N  0.746
2013 Li B, Tempel W, Smil D, Bolshan Y, Schapira M, Park HW. Crystal structures of Klebsiella pneumoniae pantothenate kinase in complex with N-substituted pantothenamides. Proteins. 81: 1466-72. PMID 23553820 DOI: 10.1002/Prot.24290  0.719
2013 Liu F, Li F, Ma A, Dobrovetsky E, Dong A, Gao C, Korboukh I, Liu J, Smil D, Brown PJ, Frye SV, Arrowsmith CH, Schapira M, Vedadi M, Jin J. Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. Journal of Medicinal Chemistry. 56: 2110-24. PMID 23445220 DOI: 10.1021/Jm3018332  0.369
2013 Yu W, Smil D, Li F, Tempel W, Fedorov O, Nguyen KT, Bolshan Y, Al-Awar R, Knapp S, Arrowsmith CH, Vedadi M, Brown PJ, Schapira M. Bromo-deaza-SAH: a potent and selective DOT1L inhibitor. Bioorganic & Medicinal Chemistry. 21: 1787-94. PMID 23433670 DOI: 10.1016/J.Bmc.2013.01.049  0.728
2013 Nguyen KT, Li F, Poda G, Smil D, Vedadi M, Schapira M. Strategy to target the substrate binding site of SET domain protein methyltransferases. Journal of Chemical Information and Modeling. 53: 681-91. PMID 23410263 DOI: 10.1021/Ci300596X  0.334
2013 Bullwinkle TJ, Zou SB, Rajkovic A, Hersch SJ, Elgamal S, Robinson N, Smil D, Bolshan Y, Navarre WW, Ibba M. (R)-β-lysine-modified elongation factor P functions in translation elongation. The Journal of Biological Chemistry. 288: 4416-23. PMID 23277358 DOI: 10.1074/Jbc.M112.438879  0.693
2013 Senisterra G, Wu H, Allali-Hassani A, Wasney GA, Barsyte-Lovejoy D, Dombrovski L, Dong A, Nguyen KT, Smil D, Bolshan Y, Hajian T, He H, Seitova A, Chau I, Li F, et al. Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. The Biochemical Journal. 449: 151-9. PMID 22989411 DOI: 10.1042/Bj20121280  0.724
2012 Siarheyeva A, Senisterra G, Allali-Hassani A, Dong A, Dobrovetsky E, Wasney GA, Chau I, Marcellus R, Hajian T, Liu F, Korboukh I, Smil D, Bolshan Y, Min J, Wu H, et al. An allosteric inhibitor of protein arginine methyltransferase 3. Structure (London, England : 1993). 20: 1425-35. PMID 22795084 DOI: 10.1016/J.Str.2012.06.001  0.73
2009 Tessier P, Smil DV, Wahhab A, Leit S, Rahil J, Li Z, Déziel R, Besterman JM. Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 5684-8. PMID 19699639 DOI: 10.1016/J.Bmcl.2009.08.010  0.331
2009 Smil DV, Manku S, Chantigny YA, Leit S, Wahhab A, Yan TP, Fournel M, Maroun C, Li Z, Lemieux AM, Nicolescu A, Rahil J, Lefebvre S, Panetta A, Besterman JM, et al. Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 688-92. PMID 19111466 DOI: 10.1016/J.Bmcl.2008.12.045  0.348
2009 Wahhab A, Smil D, Ajamian A, Allan M, Chantigny Y, Therrien E, Nguyen N, Manku S, Leit S, Rahil J, Petschner AJ, Lu AH, Nicolescu A, Lefebvre S, Montcalm S, et al. Sulfamides as novel histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 336-40. PMID 19084395 DOI: 10.1016/J.Bmcl.2008.11.081  0.305
2004 Laurent A, Villalva-Servín NP, Forgione P, Wilson PD, Smil DV, Fallis AG. Part 1: Efficient strategies for the construction of variably substituted bicyclo[5.3.1]undecenones (AB taxane ring systems) Canadian Journal of Chemistry. 82: 215-226. DOI: 10.1139/V03-200  0.373
2002 Batey RA, Quach TD, Shen M, Thadani AN, Smil DV, Li SW, MacKay DB. Organoboron compounds as mild nucleophiles in Lewis acid- and transition metal-catalyzed C-C bond-forming reactions Pure and Applied Chemistry. 74: 43-55. DOI: 10.1351/Pac200274010043  0.728
2002 Thadani AN, Batey RA, Lough AJ, Smil DV. (E)-2-Styryl-[1,3,6,2]dioxazaborolane Acta Crystallographica Section E Structure Reports Online. 58: o238-o239. DOI: 10.1107/S1600536802001691  0.718
2001 Thadani AN, Batey RA, Smil DV, Lough AJ. Potassium trifluoro[(E)-2-phenyl-1-ethenyl]borate Acta Crystallographica Section E Structure Reports Online. 57: m333-m334. DOI: 10.1107/S1600536801010169  0.708
2001 Batey RA, Thadani AN, Smil DV, Lough AJ. Diastereoselective allylation and crotylation reactions of aldehydes with potassium allyl- and crotyltrifluoroborates under Lewis acid catalysis Synthesis. 990-998. DOI: 10.1055/S-2000-6303  0.738
2001 Batey RA, Thadani AN, Smil DV, Lough AJ. Diastereoselective allylation and crotylation reactions of aldehydes with potassium allyl- and crotyltrifluoroborates under Lewis acid catalysis Synthesis. 990-998.  0.685
1999 Batey RA, Smil DV. The First Boron-Tethered Radical Cyclizations and Intramolecular Homolytic Substitutions at Boron. Angewandte Chemie (International Ed. in English). 38: 1798-1800. PMID 29711210 DOI: 10.1002/(Sici)1521-3773(19990614)38:12<1798::Aid-Anie1798>3.0.Co;2-0  0.591
1999 Batey RA, Thadani AN, Smil DV. Potassium alkenyl- and aryltrifluoroborates: Stable and efficient agents for rhodium-catalyzed addition to aldehydes and enones Organic Letters. 1: 1683-1686. DOI: 10.1021/Ol9910767  0.738
1999 Batey RA, Smil DV. Tethered α-boryl radical cyclizations of haloalkyl boronates Tetrahedron Letters. 40: 9183-9187. DOI: 10.1016/S0040-4039(99)01970-X  0.563
1999 Batey RA, Thadani AN, Smil DV. Potassium allyl- and crotyltrifluoroborates: Stable and efficient agents for allylation and crotylation Tetrahedron Letters. 40: 4289-4292. DOI: 10.1016/S0040-4039(99)00774-1  0.733
1999 Batey RA, Smil DV. Erste durch Verknüpfung über Bor vermittelte radikalische Cyclisierungen und intramolekulare homolytische Substitutionen an Bor Angewandte Chemie. 111: 1914-1917. DOI: 10.1002/(Sici)1521-3757(19990614)111:12<1914::Aid-Ange1914>3.0.Co;2-A  0.468
1999 Batey RA, Smil DV. The first boron-tethered radical cyclizations and intramolecular homolytic substitutions at boron Angewandte Chemie - International Edition. 38: 1798-1800.  0.521
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