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Huanghe Yang, Ph.D. - Publications

Affiliations: 
2015- Biochemistry Duke Medical School, Durham, NC, United States 
Area:
Ion channels, biophysics, electrophysiology, neuroscience
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49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Zhang G, Yang H, Wang Y, Liang H, Shi J, Cui J. Redox dependent Cd inhibition of BK type Ca activated K channels. Biophysical Journal. PMID 38400542 DOI: 10.1016/j.bpj.2024.02.015  0.677
2024 Lowry AJ, Liang P, Serena Wan YC, Pei ZM, Yang H, Zhang Y. TMEM16 and TMEM63/OSCA proteins share a conserved potential to permeate ions and phospholipids. Biorxiv : the Preprint Server For Biology. PMID 38370744 DOI: 10.1101/2024.02.04.578431  0.384
2023 Liang P, Zhang Y, Wan YC, Ma S, Dong P, Lowry AJ, Francis SJ, Khandelwal S, Delahunty M, Telen MJ, Strouse JJ, Arepally GM, Yang H. Deciphering and Disrupting PIEZO1-TMEM16F Interplay in Hereditary Xerocytosis. Blood. PMID 38033286 DOI: 10.1182/blood.2023021465  0.55
2023 Shan KZ, Le T, Liang P, Dong P, Yang H. Endothelial TMEM16F lipid scramblase regulates angiogenesis. Biorxiv : the Preprint Server For Biology. PMID 37645870 DOI: 10.1101/2023.08.17.553724  0.424
2022 Zhang Y, Liang P, Yang L, Shan KZ, Feng L, Chen Y, Liedtke W, Coyne CB, Yang H. Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion. Elife. 11. PMID 35670667 DOI: 10.7554/eLife.78840  0.447
2022 Dong P, Zhang Y, Hunanyan AS, Mikati MA, Cui J, Yang H. Neuronal mechanism of a BK channelopathy in absence epilepsy and dyskinesia. Proceedings of the National Academy of Sciences of the United States of America. 119: e2200140119. PMID 35286197 DOI: 10.1073/pnas.2200140119  0.646
2022 Zhou Q, Doherty J, Akk A, Springer LE, Fan P, Spasojevic I, Halade GV, Yang H, Pham CTN, Wickline SA, Pan H. Safety Profile of Rapamycin Perfluorocarbon Nanoparticles for Preventing Cisplatin-Induced Kidney Injury. Nanomaterials (Basel, Switzerland). 12. PMID 35159680 DOI: 10.3390/nano12030336  0.344
2022 Le SC, Yang H. Structure-Function of TMEM16 Ion Channels and Lipid Scramblases. Advances in Experimental Medicine and Biology. 1349: 87-109. PMID 35138612 DOI: 10.1007/978-981-16-4254-8_6  0.449
2021 Le SC, Liang P, Lowry AJ, Yang H. Gating and Regulatory Mechanisms of TMEM16 Ion Channels and Scramblases. Frontiers in Physiology. 12: 787773. PMID 34867487 DOI: 10.3389/fphys.2021.787773  0.363
2021 Liang P, Yang H. Molecular underpinning of intracellular pH regulation on TMEM16F. The Journal of General Physiology. 153. PMID 33346788 DOI: 10.1085/jgp.202012704  0.373
2020 Le SC, Yang H. An Additional Ca Binding Site Allosterically Controls TMEM16A Activation. Cell Reports. 33: 108570. PMID 33378669 DOI: 10.1016/j.celrep.2020.108570  0.44
2020 Le T, Le SC, Zhang Y, Liang P, Yang H. Evidence that polyphenols do not inhibit the phospholipid scramblase TMEM16F. The Journal of Biological Chemistry. PMID 32709749 DOI: 10.1074/jbc.AC120.014872  0.392
2020 Zhang G, Gibson RA, McDonald M, Liang P, Kang PW, Shi J, Yang H, Cui J, Mikati MA. A Gain-of-Function Mutation in KCNMA1 Causes Dystonia Spells Controlled With Stimulant Therapy. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 32633875 DOI: 10.1002/mds.28138  0.603
2020 Zhang Y, Le T, Grabau R, Mohseni Z, Kim H, Natale DR, Feng L, Pan H, Yang H. TMEM16F phospholipid scramblase mediates trophoblast fusion and placental development. Science Advances. 6: eaba0310. PMID 32494719 DOI: 10.1126/Sciadv.Aba0310  0.502
2020 Liang P, Le TP, Le SC, Yang H. Molecular Mechanism of pH Regulation on TMEM16F Lipid Scramblase and Ion Channel Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.3152  0.421
2020 Le SC, Yang H. An Allosteric Gating Mechanism of TMEM16A Calcium-Activated Chloride Channel Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.1554  0.575
2019 Le SC, Jia Z, Chen J, Yang H. Molecular basis of PIP-dependent regulation of the Ca-activated chloride channel TMEM16A. Nature Communications. 10: 3769. PMID 31434906 DOI: 10.1038/S41467-019-11784-8  0.631
2019 Le T, Jia Z, Le SC, Zhang Y, Chen J, Yang H. An inner activation gate controls TMEM16F phospholipid scrambling. Nature Communications. 10: 1846. PMID 31015464 DOI: 10.1038/S41467-019-09778-7  0.539
2019 Yin Y, Le SC, Hsu AL, Borgnia MJ, Yang H, Lee SY. Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel. Science (New York, N.Y.). PMID 30733385 DOI: 10.2210/Pdb6Nr2/Pdb  0.476
2019 Le T, Le SC, Yang H. Subdued is a moonlighting transmembrane protein 16 (TMEM16) that transports ions and phospholipids. The Journal of Biological Chemistry. PMID 30700552 DOI: 10.1074/jbc.AC118.006530  0.467
2018 Zubcevic L, Le S, Yang H, Lee SY. Conformational plasticity in the selectivity filter of the TRPV2 ion channel. Nature Structural & Molecular Biology. 25: 405-415. PMID 29728656 DOI: 10.2210/Pdb6Bwj/Pdb  0.488
2017 Zhou Y, Yang H, Cui J, Lingle CJ. Threading the biophysics of mammalian Slo1 channels onto structures of an invertebrate Slo1 channel. The Journal of General Physiology. PMID 29025867 DOI: 10.1085/jgp.201711845  0.755
2017 Zhang Y, Zhang Z, Xiao S, Tien J, Le S, Le T, Jan LY, Yang H. Inferior Olivary TMEM16B Mediates Cerebellar Motor Learning. Neuron. 95: 1103-1111.e4. PMID 28858616 DOI: 10.1016/J.Bpj.2017.11.752  0.761
2016 Jiang Y, Yu B, Yang H, Ma T. Shikonin Inhibits Intestinal Calcium-Activated Chloride Channels and Prevents Rotaviral Diarrhea. Frontiers in Pharmacology. 7: 270. PMID 27601995 DOI: 10.3389/fphar.2016.00270  0.428
2015 Huang X, He Y, Dubuc AM, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens SJ, Younger S, Barshow S, Zhu S, Cooper MK, Peacock J, Ramaswamy V, et al. EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. Nature Neuroscience. PMID 26258683 DOI: 10.1038/Nn.4088  0.792
2015 Yang H, Zhang G, Cui J. BK channels: multiple sensors, one activation gate. Frontiers in Physiology. 6: 29. PMID 25705194 DOI: 10.3389/fphys.2015.00029  0.676
2014 Zhang G, Yang H, Liang H, Yang J, Shi J, McFarland K, Chen Y, Cui J. A charged residue in S4 regulates coupling among the activation gate, voltage, and Ca2+ sensors in BK channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 12280-8. PMID 25209270 DOI: 10.1523/Jneurosci.1174-14.2014  0.799
2014 Tien J, Peters CJ, Wong XM, Cheng T, Jan YN, Jan LY, Yang H. A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity. Elife. 3. PMID 24980701 DOI: 10.7554/Elife.02772  0.772
2014 Hong T, Yang H, Zhang SS, Cho HC, Kalashnikova M, Sun B, Zhang H, Bhargava A, Grabe M, Olgin J, Gorelik J, Marbán E, Jan LY, Shaw RM. Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia. Nature Medicine. 20: 624-32. PMID 24836577 DOI: 10.1038/Nm.3543  0.614
2014 Tien J, Peters CJ, Wong XM, Cheng T, Jan YN, Jan LY, Yang H. Author response: A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity Elife. DOI: 10.7554/Elife.02772.012  0.749
2013 Sun X, Shi J, Delaloye K, Yang X, Yang H, Zhang G, Cui J. The interface between membrane-spanning and cytosolic domains in Ca²+-dependent K+ channels is involved in β subunit modulation of gating. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 11253-61. PMID 23825428 DOI: 10.1523/JNEUROSCI.0620-13.2013  0.731
2013 Yang J, Yang H, Sun X, Delaloye K, Yang X, Moller A, Shi J, Cui J. Interaction between residues in the Mg2+-binding site regulates BK channel activation. The Journal of General Physiology. 141: 217-28. PMID 23359284 DOI: 10.1085/Jgp.201210794  0.794
2013 Zhang G, Yang J, Yang H, Shi J, Yang X, Delaloye K, Moller A, Cui J. Electrostatic Interaction between the S4-S5 Linker and the Cytoplasmic End of S6 Regulates BK Channel Gating Biophysical Journal. 104: 462a-463a. DOI: 10.1016/J.Bpj.2012.11.2559  0.798
2012 Yang H, Kim A, David T, Palmer D, Jin T, Tien J, Huang F, Cheng T, Coughlin SR, Jan YN, Jan LY. TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell. 151: 111-22. PMID 23021219 DOI: 10.1016/J.Bpj.2012.11.2033  0.791
2012 Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, et al. Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proceedings of the National Academy of Sciences of the United States of America. 109: 16354-9. PMID 22988107 DOI: 10.1073/Pnas.1214596109  0.709
2012 Berg J, Yang H, Jan LY. Ca2+-activated Cl- channels at a glance. Journal of Cell Science. 125: 1367-71. PMID 22526416 DOI: 10.1242/jcs.093260  0.686
2012 Kim AY, Yang H, David T, Tien J, Coughlin SR, Jan YN, Jan L. TMEM16F Ion Channel Regulates Calcium-Dependent PS Exposure, Hemostasis, and Thrombosis Blood. 120: 1111-1111. DOI: 10.1182/Blood.V120.21.1111.1111  0.797
2012 Sun X, Shi J, Yang X, Delaloye K, Yang H, Cui J. Accessory Beta Subunits Alter the Interaction Between the Membrane-Spanning and Cytosolic Domains in BK Channels Biophysical Journal. 102: 684a. DOI: 10.1016/j.bpj.2011.11.3719  0.671
2011 Yang H, Jin T, Cheng T, Jan YN, Jan LY. Scan: A Novel Small-Conductance Ca2+-Activated Non-Selective Cation Channel Encoded by TMEM16F Biophysical Journal. 100: 259a. DOI: 10.1016/J.Bpj.2010.12.1631  0.719
2010 Yang J, Krishnamoorthy G, Saxena A, Zhang G, Shi J, Yang H, Delaloye K, Sept D, Cui J. An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing. Neuron. 66: 871-83. PMID 20620873 DOI: 10.1016/J.Neuron.2010.05.009  0.803
2010 Yang J(, Krishnamoorthy G, Saxena A, Zhang G, Shi J, Yang H, Delaloye K, Sept D, Cui J. An Epilepsy-Associated Mutation Enhances BK Channel Activity by Altering the Coupling of Calcium Sensing to Gate Activation Biophysical Journal. 98: 316a-317a. DOI: 10.1016/J.Bpj.2009.12.1718  0.775
2009 Cui J, Yang H, Lee US. Molecular mechanisms of BK channel activation. Cellular and Molecular Life Sciences : Cmls. 66: 852-75. PMID 19099186 DOI: 10.1007/S00018-008-8609-X  0.817
2009 Yang H, Shi J, Cui J. Gate Opening Remotely Controls the Interaction between the Voltage Sensor and the Cytosolic Domain in BK Channels Biophysical Journal. 96: 481a. DOI: 10.1016/j.bpj.2008.12.2479  0.723
2008 Yang H, Shi J, Zhang G, Yang J, Delaloye K, Cui J. Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains. Nature Structural & Molecular Biology. 15: 1152-9. PMID 18931675 DOI: 10.1038/Nsmb.1507  0.788
2008 Yang H, Zhang G, Shi J, Lee US, Delaloye K, Cui J. Subunit-specific effect of the voltage sensor domain on Ca2+ sensitivity of BK channels. Biophysical Journal. 94: 4678-87. PMID 18339745 DOI: 10.1529/Biophysj.107.121590  0.782
2007 Yang H, Hu L, Shi J, Delaloye K, Horrigan FT, Cui J. Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels. Proceedings of the National Academy of Sciences of the United States of America. 104: 18270-5. PMID 17984060 DOI: 10.1073/pnas.0705873104  0.759
2006 Yang H, Hu L, Shi J, Cui J. Tuning magnesium sensitivity of BK channels by mutations. Biophysical Journal. 91: 2892-900. PMID 16877509 DOI: 10.1529/biophysj.106.090159  0.686
2006 Hu L, Yang H, Shi J, Cui J. Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels. The Journal of General Physiology. 127: 35-49. PMID 16344323 DOI: 10.1085/jgp.200509317  0.747
2005 Du W, Bautista JF, Yang H, Diez-Sampedro A, You SA, Wang L, Kotagal P, Lüders HO, Shi J, Cui J, Richerson GB, Wang QK. Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder. Nature Genetics. 37: 733-8. PMID 15937479 DOI: 10.1038/Ng1585  0.719
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