| Year |
Citation |
Score |
| 2023 |
Zhang B, Duan H, Kavaler J, Wei L, Eberl DF, Lai EC. A nonneural miRNA cluster mediates hearing via repression of two neural targets. Genes & Development. 37: 1041-1051. PMID 38110249 DOI: 10.1101/gad.351052.123 |
0.402 |
|
| 2023 |
Khanal S, de Cruz M, Strickland B, Mansfield K, Lai EC, Flynt A. A tailed mirtron promotes longevity in Drosophila. Nucleic Acids Research. PMID 38048325 DOI: 10.1093/nar/gkad1158 |
0.748 |
|
| 2023 |
Shang R, Lai EC. Parameters of clustered suboptimal miRNA biogenesis. Proceedings of the National Academy of Sciences of the United States of America. 120: e2306727120. PMID 37788316 DOI: 10.1073/pnas.2306727120 |
0.365 |
|
| 2023 |
Signor S, Vedanayagam J, Kim BY, Wierzbicki F, Kofler R, Lai EC. Rapid evolutionary diversification of the flamenco locus across simulans clade Drosophila species. Plos Genetics. 19: e1010914. PMID 37643184 DOI: 10.1371/journal.pgen.1010914 |
0.757 |
|
| 2023 |
Wang Z, Wang Y, Zhou T, Chen S, Morris D, Magalhães RDM, Li M, Wang S, Wang H, Xie Y, McSwiggin H, Oliver D, Yuan S, Zheng H, Mohammed J, ... Lai EC, et al. The Rapidly Evolving X-linked Family Finetunes Spermatogenesis to Enhance Sperm Competition. Biorxiv : the Preprint Server For Biology. PMID 37398484 DOI: 10.1101/2023.06.14.544876 |
0.385 |
|
| 2023 |
Shang R, Lee S, Senavirathne G, Lai EC. microRNAs in action: biogenesis, function and regulation. Nature Reviews. Genetics. PMID 37380761 DOI: 10.1038/s41576-023-00611-y |
0.427 |
|
| 2023 |
Vedanayagam J, Lin CJ, Papareddy R, Nodine M, Flynt AS, Wen J, Lai EC. Regulatory logic of endogenous RNAi in silencing de novo genomic conflicts. Plos Genetics. 19: e1010787. PMID 37343034 DOI: 10.1371/journal.pgen.1010787 |
0.787 |
|
| 2023 |
Vedanayagam J, Herbette M, Mudgett H, Lin CJ, Lai CM, McDonough-Goldstein C, Dorus S, Loppin B, Meiklejohn C, Dubruille R, Lai EC. Essential and recurrent roles for hairpin RNAs in silencing de novo sex chromosome conflict in Drosophila simulans. Plos Biology. 21: e3002136. PMID 37289846 DOI: 10.1371/journal.pbio.3002136 |
0.767 |
|
| 2023 |
Pan A, Zeng Y, Liu J, Zhou M, Lai EC, Yu Y. Unanticipated broad phylogeny of BEN DNA-binding domains revealed by structural homology searches. Current Biology : Cb. PMID 37236184 DOI: 10.1016/j.cub.2023.05.011 |
0.771 |
|
| 2023 |
Lee S, Jee D, Srivastava S, Yang A, Ramidi A, Shang R, Bortolamiol-Becet D, Pfeffer S, Gu S, Wen J, Lai EC. Promiscuous splicing-derived hairpins are dominant substrates of tailing-mediated defense of miRNA biogenesis in mammals. Cell Reports. 42: 112111. PMID 36800291 DOI: 10.1016/j.celrep.2023.112111 |
0.441 |
|
| 2022 |
Lee S, Chen YC, Gillen AE, Taliaferro JM, Deplancke B, Li H, Lai EC. Diverse cell-specific patterns of alternative polyadenylation in Drosophila. Nature Communications. 13: 5372. PMID 36100597 DOI: 10.1038/s41467-022-32305-0 |
0.322 |
|
| 2022 |
Shang R, Kretov DA, Adamson SI, Treiber T, Treiber N, Vedanayagam J, Chuang JH, Meister G, Cifuentes D, Lai EC. Regulated dicing of pre-mir-144 via reshaping of its terminal loop. Nucleic Acids Research. PMID 35801921 DOI: 10.1093/nar/gkac568 |
0.78 |
|
| 2021 |
Vedanayagam J, Lin CJ, Lai EC. Rapid evolutionary dynamics of an expanding family of meiotic drive factors and their hpRNA suppressors. Nature Ecology & Evolution. PMID 34862477 DOI: 10.1038/s41559-021-01592-z |
0.763 |
|
| 2021 |
Garaulet DL, Moro A, Lai EC. A double-negative gene regulatory circuit underlies the virgin behavioral state. Cell Reports. 36: 109335. PMID 34233178 DOI: 10.1016/j.celrep.2021.109335 |
0.313 |
|
| 2021 |
Bejarano F, Lai EC. A comprehensive dataset of microRNA misexpression phenotypes in the eye. Data in Brief. 36: 107037. PMID 34007867 DOI: 10.1016/j.dib.2021.107037 |
0.394 |
|
| 2021 |
Bejarano F, Chang CH, Sun K, Hagen JW, Deng WM, Lai EC. A comprehensive in vivo screen for anti-apoptotic miRNAs indicates broad capacities for oncogenic synergy. Developmental Biology. PMID 33662357 DOI: 10.1016/j.ydbio.2021.02.010 |
0.427 |
|
| 2020 |
Garaulet DL, Zhang B, Wei L, Li E, Lai EC. miRNAs and Neural Alternative Polyadenylation Specify the Virgin Behavioral State. Developmental Cell. PMID 32579967 DOI: 10.1016/j.devcel.2020.06.004 |
0.375 |
|
| 2020 |
Shang R, Baek SC, Kim K, Kim B, Kim VN, Lai EC. Genomic Clustering Facilitates Nuclear Processing of Suboptimal Pri-miRNA Loci. Molecular Cell. 78: 303-316.e4. PMID 32302542 DOI: 10.1016/j.molcel.2020.02.009 |
0.394 |
|
| 2020 |
Wang J, Lee JE, Riemondy K, Yu Y, Marquez SM, Lai EC, Yi R. XPO5 promotes primary miRNA processing independently of RanGTP. Nature Communications. 11: 1845. PMID 32296071 DOI: 10.1038/S41467-020-15598-X |
0.438 |
|
| 2020 |
Wang J, Lee J, Riemondy K, Yu Y, Marquez S, Lai EC, Yi R. XPO5 promotes primary miRNA processing independently of RanGTP Nature Communications. 15: 845. DOI: doi: 10.1038/s41467-020-15598-x. |
0.37 |
|
| 2019 |
Vedanayagam J, Chatila WK, Aksoy BA, Majumdar S, Skanderup AJ, Demir E, Schultz N, Sander C, Lai EC. Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis. Nature Communications. 10: 3682. PMID 31417090 DOI: 10.1038/S41467-019-11610-1 |
0.796 |
|
| 2019 |
Mohammed J, Flynt AS, Panzarino AM, Mondal MMH, DeCruz M, Siepel A, Lai EC. Erratum: Deep experimental profiling of microRNA diversity, deployment, and evolution across the genus. Genome Research. 29: 881. PMID 31043510 DOI: 10.1101/gr.250654.119 |
0.673 |
|
| 2018 |
Teijeiro V, Yang D, Majumdar S, González F, Rickert RW, Xu C, Koche R, Verma N, Lai EC, Huangfu D. DICER1 Is Essential for Self-Renewal of Human Embryonic Stem Cells. Stem Cell Reports. PMID 30146489 DOI: 10.1016/J.Stemcr.2018.07.013 |
0.41 |
|
| 2018 |
Lin CJ, Hu F, Dubruille R, Vedanayagam J, Wen J, Smibert P, Loppin B, Lai EC. The hpRNA/RNAi Pathway Is Essential to Resolve Intragenomic Conflict in the Drosophila Male Germline. Developmental Cell. 46: 316-326.e5. PMID 30086302 DOI: 10.1016/J.Devcel.2018.07.004 |
0.79 |
|
| 2018 |
Duan H, de Navas LF, Hu F, Sun K, Mavromatakis YE, Viets K, Zhou C, Kavaler J, Johnston RJ, Tomlinson A, Lai EC. Thecluster represses receptor tyrosine kinase signaling to determine cell fates in theeye. Development (Cambridge, England). PMID 29540498 DOI: 10.1242/Dev.159053 |
0.533 |
|
| 2018 |
Jee D, Yang JS, Park SM, Farmer DT, Wen J, Chou T, Chow A, McManus MT, Kharas MG, Lai EC. Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals. Molecular Cell. 69: 265-278.e6. PMID 29351846 DOI: 10.1016/J.Molcel.2017.12.027 |
0.332 |
|
| 2017 |
Mohammed J, Flynt AS, Panzarino AM, Mondal MMH, DeCruz M, Siepel A, Lai EC. Deep experimental profiling of microRNA diversity, deployment, and evolution across the Drosophila genus. Genome Research. PMID 29233922 DOI: 10.1101/Gr.226068.117 |
0.744 |
|
| 2017 |
Kavaler J, Duan H, Aradhya R, de Navas LF, Joseph B, Shklyar B, Lai EC. miRNA suppression of a Notch repressor directs non-neuronal fate in Drosophila mechanosensory organs. The Journal of Cell Biology. PMID 29196461 DOI: 10.1083/jcb.201706101 |
0.381 |
|
| 2017 |
Kondo S, Vedanayagam J, Mohammed J, Eizadshenass S, Kan L, Pang N, Aradhya R, Siepel A, Steinhauer J, Lai EC. New genes often acquire male-specific functions but rarely become essential in Drosophila. Genes & Development. 31: 1841-1846. PMID 29051389 DOI: 10.1101/Gad.303131.117 |
0.741 |
|
| 2017 |
Kan L, Grozhik AV, Vedanayagam J, Patil DP, Pang N, Lim KS, Huang YC, Joseph B, Lin CJ, Despic V, Guo J, Yan D, Kondo S, Deng WM, Dedon PC, ... ... Lai EC, et al. The m(6)A pathway facilitates sex determination in Drosophila. Nature Communications. 8: 15737. PMID 28675155 DOI: 10.1038/Ncomms15737 |
0.729 |
|
| 2017 |
Sanfilippo P, Smibert P, Duan H, Lai EC. Correction: Neural specificity of the RNA-binding protein Elav is achieved by post-transcriptional repression in non-neural tissues. Development (Cambridge, England). 144: 1578. PMID 28400435 DOI: 10.1242/dev.151753 |
0.655 |
|
| 2016 |
Lin CJ, Wen J, Bejarano F, Hu F, Bortolamiol-Becet D, Kan L, Sanfilippo P, Kondo S, Lai EC. Characterization of a TUTase/nuclease complex required for Drosophila gametogenesis. Rna (New York, N.Y.). PMID 27974621 DOI: 10.1261/rna.059527.116 |
0.389 |
|
| 2016 |
Sanfilippo P, Smibert P, Duan H, Lai EC. Neural specificity of the RNA binding protein Elav is achieved by post-transcriptional repression in non-neural tissues. Development (Cambridge, England). PMID 27802174 DOI: 10.1242/Dev.141978 |
0.744 |
|
| 2015 |
Lin CJ, Smibert P, Zhao X, Hu JF, Ramroop J, Kellner SM, Benton MA, Govind S, Dedon PC, Sternglanz R, Lai EC. An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis. Rna (New York, N.Y.). PMID 26516084 DOI: 10.1261/Rna.053934.115 |
0.66 |
|
| 2015 |
Wen J, Ladewig E, Shenker S, Mohammed J, Lai EC. Analysis of Nearly One Thousand Mammalian Mirtrons Reveals Novel Features of Dicer Substrates. Plos Computational Biology. 11: e1004441. PMID 26325366 DOI: 10.1371/journal.pcbi.1004441 |
0.459 |
|
| 2015 |
Garaulet DL, Lai EC. Hox miRNA regulation within the Drosophila Bithorax complex: Patterning behavior. Mechanisms of Development. PMID 26311219 DOI: 10.1016/j.mod.2015.08.006 |
0.416 |
|
| 2015 |
Bortolamiol-Becet D, Hu F, Jee D, Wen J, Okamura K, Lin CJ, Ameres SL, Lai EC. Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor. Molecular Cell. PMID 26145174 DOI: 10.1016/J.Molcel.2015.05.034 |
0.68 |
|
| 2015 |
Fulga TA, McNeill EM, Binari R, Yelick J, Blanche A, Booker M, Steinkraus BR, Schnall-Levin M, Zhao Y, DeLuca T, Bejarano F, Han Z, Lai EC, Wall DP, Perrimon N, et al. A transgenic resource for conditional competitive inhibition of conserved Drosophila microRNAs. Nature Communications. 6: 7279. PMID 26081261 DOI: 10.1038/Ncomms8279 |
0.404 |
|
| 2015 |
Lai EC. Two decades of miRNA biology: lessons and challenges. Rna (New York, N.Y.). 21: 675-7. PMID 25780186 DOI: 10.1261/rna.051193.115 |
0.374 |
|
| 2015 |
Chak LL, Mohammed J, Lai EC, Tucker-Kellogg G, Okamura K. A deeply conserved, noncanonical miRNA hosted by ribosomal DNA. Rna (New York, N.Y.). 21: 375-84. PMID 25605965 DOI: 10.1261/Rna.049098.114 |
0.682 |
|
| 2015 |
Wen J, Duan H, Bejarano F, Okamura K, Fabian L, Brill JA, Bortolamiol-Becet D, Martin R, Ruby JG, Lai EC. Adaptive regulation of testis gene expression and control of male fertility by the Drosophila harpin RNA pathway. Molecular Cell. 57: 165-78. PMID 25544562 DOI: 10.1016/J.Molcel.2014.11.025 |
0.632 |
|
| 2014 |
Westholm JO, Miura P, Olson S, Shenker S, Joseph B, Sanfilippo P, Celniker SE, Graveley BR, Lai EC. Genome-wide analysis of drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation. Cell Reports. 9: 1966-80. PMID 25544350 DOI: 10.1016/J.Celrep.2014.10.062 |
0.375 |
|
| 2014 |
Hu F, Lai EC, Okamura K. A signaling-induced switch in dicer localization and function. Developmental Cell. 31: 523-4. PMID 25490263 DOI: 10.1016/J.Devcel.2014.11.032 |
0.546 |
|
| 2014 |
Mohammed J, Siepel A, Lai EC. Diverse modes of evolutionary emergence and flux of conserved microRNA clusters. Rna (New York, N.Y.). 20: 1850-63. PMID 25332374 DOI: 10.1261/Rna.046805.114 |
0.379 |
|
| 2014 |
Gerstein MB, Rozowsky J, Yan KK, Wang D, Cheng C, Brown JB, Davis CA, Hillier L, Sisu C, Li JJ, Pei B, Harmanci AO, Duff MO, Djebali S, Alexander RP, ... ... Lai E, et al. Comparative analysis of the transcriptome across distant species. Nature. 512: 445-8. PMID 25164755 DOI: 10.1038/Nature13424 |
0.557 |
|
| 2014 |
Fagegaltier D, König A, Gordon A, Lai EC, Gingeras TR, Hannon GJ, Shcherbata HR. A genome-wide survey of sexually dimorphic expression of Drosophila miRNAs identifies the steroid hormone-induced miRNA let-7 as a regulator of sexual identity. Genetics. 198: 647-68. PMID 25081570 DOI: 10.1534/Genetics.114.169268 |
0.363 |
|
| 2014 |
Wen J, Mohammed J, Bortolamiol-Becet D, Tsai H, Robine N, Westholm JO, Ladewig E, Dai Q, Okamura K, Flynt AS, Zhang D, Andrews J, Cherbas L, Kaufman TC, Cherbas P, ... ... Lai EC, et al. Diversity of miRNAs, siRNAs, and piRNAs across 25 Drosophila cell lines. Genome Research. 24: 1236-50. PMID 24985917 DOI: 10.1101/Gr.161554.113 |
0.804 |
|
| 2014 |
Mohammed J, Bortolamiol-Becet D, Flynt AS, Gronau I, Siepel A, Lai EC. Adaptive evolution of testis-specific, recently evolved, clustered miRNAs in Drosophila. Rna (New York, N.Y.). 20: 1195-209. PMID 24942624 DOI: 10.1261/Rna.044644.114 |
0.743 |
|
| 2014 |
Garaulet DL, Castellanos MC, Bejarano F, Sanfilippo P, Tyler DM, Allan DW, Sánchez-Herrero E, Lai EC. Homeotic function of Drosophila Bithorax-complex miRNAs mediates fertility by restricting multiple Hox genes and TALE cofactors in the CNS. Developmental Cell. 29: 635-48. PMID 24909902 DOI: 10.1016/J.Devcel.2014.04.023 |
0.395 |
|
| 2014 |
Jee D, Lai EC. Alteration of miRNA activity via context-specific modifications of Argonaute proteins. Trends in Cell Biology. 24: 546-53. PMID 24865524 DOI: 10.1016/j.tcb.2014.04.008 |
0.439 |
|
| 2014 |
Yang JS, Smibert P, Westholm JO, Jee D, Maurin T, Lai EC. Intertwined pathways for Argonaute-mediated microRNA biogenesis in Drosophila. Nucleic Acids Research. 42: 1987-2002. PMID 24220090 DOI: 10.1093/Nar/Gkt1038 |
0.75 |
|
| 2013 |
Jin Z, Flynt AS, Lai EC. Drosophila piwi mutants exhibit germline stem cell tumors that are sustained by elevated Dpp signaling. Current Biology : Cb. 23: 1442-8. PMID 23891114 DOI: 10.1016/j.cub.2013.06.021 |
0.643 |
|
| 2013 |
Mohammed J, Flynt AS, Siepel A, Lai EC. The impact of age, biogenesis, and genomic clustering on Drosophila microRNA evolution. Rna (New York, N.Y.). 19: 1295-308. PMID 23882112 DOI: 10.1261/Rna.039248.113 |
0.745 |
|
| 2013 |
Pancratov R, Peng F, Smibert P, Yang S, Olson ER, Guha-Gilford C, Kapoor AJ, Liang FX, Lai EC, Flaherty MS, DasgGupta R. The miR-310/13 cluster antagonizes β-catenin function in the regulation of germ and somatic cell differentiation in the Drosophila testis. Development (Cambridge, England). 140: 2904-16. PMID 23821034 DOI: 10.1242/Dev.092817 |
0.708 |
|
| 2013 |
Sun K, Lai EC. Adult-specific functions of animal microRNAs. Nature Reviews. Genetics. 14: 535-48. PMID 23817310 DOI: 10.1038/nrg3471 |
0.399 |
|
| 2013 |
Smibert P, Yang JS, Azzam G, Liu JL, Lai EC. Homeostatic control of Argonaute stability by microRNA availability. Nature Structural & Molecular Biology. 20: 789-95. PMID 23708604 DOI: 10.1038/Nsmb.2606 |
0.75 |
|
| 2013 |
Okamura K, Ladewig E, Zhou L, Lai EC. Functional small RNAs are generated from select miRNA hairpin loops in flies and mammals. Genes & Development. 27: 778-92. PMID 23535236 DOI: 10.1101/Gad.211698.112 |
0.676 |
|
| 2013 |
Miura P, Shenker S, Andreu-Agullo C, Westholm JO, Lai EC. Widespread and extensive lengthening of 3' UTRs in the mammalian brain. Genome Research. 23: 812-25. PMID 23520388 DOI: 10.1101/gr.146886.112 |
0.376 |
|
| 2013 |
Arif S, Murat S, Almudi I, Nunes MD, Bortolamiol-Becet D, McGregor NS, Currie JM, Hughes H, Ronshaugen M, Sucena É, Lai EC, Schlötterer C, McGregor AP. Evolution of mir-92a underlies natural morphological variation in Drosophila melanogaster. Current Biology : Cb. 23: 523-8. PMID 23453955 DOI: 10.1016/J.Cub.2013.02.018 |
0.38 |
|
| 2012 |
Maurin T, Cazalla D, Yang S, Bortolamiol-Becet D, Lai EC. RNase III-independent microRNA biogenesis in mammalian cells. Rna (New York, N.Y.). 18: 2166-73. PMID 23097423 DOI: 10.1261/rna.036194.112 |
0.449 |
|
| 2012 |
Ladewig E, Okamura K, Flynt AS, Westholm JO, Lai EC. Discovery of hundreds of mirtrons in mouse and human small RNA data. Genome Research. 22: 1634-45. PMID 22955976 DOI: 10.1101/Gr.133553.111 |
0.806 |
|
| 2012 |
Bejarano F, Bortolamiol-Becet D, Dai Q, Sun K, Saj A, Chou YT, Raleigh DR, Kim K, Ni JQ, Duan H, Yang JS, Fulga TA, Van Vactor D, Perrimon N, Lai EC. A genome-wide transgenic resource for conditional expression of Drosophila microRNAs. Development (Cambridge, England). 139: 2821-31. PMID 22745315 DOI: 10.1242/dev.079939 |
0.449 |
|
| 2012 |
Smibert P, Miura P, Westholm JO, Shenker S, May G, Duff MO, Zhang D, Eads BD, Carlson J, Brown JB, Eisman RC, Andrews J, Kaufman T, Cherbas P, Celniker SE, ... ... Lai EC, et al. Global patterns of tissue-specific alternative polyadenylation in Drosophila. Cell Reports. 1: 277-89. PMID 22685694 DOI: 10.1016/J.Celrep.2012.01.001 |
0.71 |
|
| 2012 |
Yang JS, Maurin T, Lai EC. Functional parameters of Dicer-independent microRNA biogenesis. Rna (New York, N.Y.). 18: 945-57. PMID 22461413 DOI: 10.1261/rna.032938.112 |
0.39 |
|
| 2012 |
Azzam G, Smibert P, Lai EC, Liu JL. Drosophila Argonaute 1 and its miRNA biogenesis partners are required for oocyte formation and germline cell division. Developmental Biology. 365: 384-94. PMID 22445511 DOI: 10.1016/J.Ydbio.2012.03.005 |
0.756 |
|
| 2012 |
Dai Q, Smibert P, Lai EC. Exploiting Drosophila genetics to understand microRNA function and regulation. Current Topics in Developmental Biology. 99: 201-35. PMID 22365740 DOI: 10.1016/B978-0-12-387038-4.00008-2 |
0.748 |
|
| 2012 |
Westholm JO, Ladewig E, Okamura K, Robine N, Lai EC. Common and distinct patterns of terminal modifications to mirtrons and canonical microRNAs. Rna (New York, N.Y.). 18: 177-92. PMID 22190743 DOI: 10.1261/Rna.030627.111 |
0.786 |
|
| 2011 |
Smibert P, Bejarano F, Wang D, Garaulet DL, Yang JS, Martin R, Bortolamiol-Becet D, Robine N, Hiesinger PR, Lai EC. A Drosophila genetic screen yields allelic series of core microRNA biogenesis factors and reveals post-developmental roles for microRNAs. Rna (New York, N.Y.). 17: 1997-2010. PMID 21947201 DOI: 10.1261/Rna.2983511 |
0.823 |
|
| 2011 |
Yang JS, Lai EC. Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants. Molecular Cell. 43: 892-903. PMID 21925378 DOI: 10.1016/j.molcel.2011.07.024 |
0.428 |
|
| 2011 |
Westholm JO, Lai EC. Mirtrons: microRNA biogenesis via splicing. Biochimie. 93: 1897-904. PMID 21712066 DOI: 10.1016/j.biochi.2011.06.017 |
0.452 |
|
| 2011 |
Flynt AS, Lai EC. RNAi in Xenopus: look before you leap. Genes & Development. 25: 1105-8. PMID 21632820 DOI: 10.1101/gad.2062911 |
0.741 |
|
| 2011 |
Dávalos A, Goedeke L, Smibert P, RamÃrez CM, Warrier NP, Andreo U, Cirera-Salinas D, Rayner K, Suresh U, Pastor-Pareja JC, Esplugues E, Fisher EA, Penalva LO, Moore KJ, Suárez Y, ... Lai EC, et al. miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling. Proceedings of the National Academy of Sciences of the United States of America. 108: 9232-7. PMID 21576456 DOI: 10.1073/Pnas.1102281108 |
0.633 |
|
| 2011 |
Berezikov E, Robine N, Samsonova A, Westholm JO, Naqvi A, Hung JH, Okamura K, Dai Q, Bortolamiol-Becet D, Martin R, Zhao Y, Zamore PD, Hannon GJ, Marra MA, Weng Z, ... ... Lai EC, et al. Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. Genome Research. 21: 203-15. PMID 21177969 DOI: 10.1101/Gr.116657.110 |
0.831 |
|
| 2011 |
Chung WJ, Agius P, Westholm JO, Chen M, Okamura K, Robine N, Leslie CS, Lai EC. Computational and experimental identification of mirtrons in Drosophila melanogaster and Caenorhabditis elegans. Genome Research. 21: 286-300. PMID 21177960 DOI: 10.1101/Gr.113050.110 |
0.779 |
|
| 2011 |
Yang JS, Phillips MD, Betel D, Mu P, Ventura A, Siepel AC, Chen KC, Lai EC. Widespread regulatory activity of vertebrate microRNA* species. Rna (New York, N.Y.). 17: 312-26. PMID 21177881 DOI: 10.1261/Rna.2537911 |
0.435 |
|
| 2011 |
Okamura K, Robine N, Liu Y, Liu Q, Lai EC. R2D2 organizes small regulatory RNA pathways in Drosophila. Molecular and Cellular Biology. 31: 884-96. PMID 21135122 DOI: 10.1128/Mcb.01141-10 |
0.805 |
|
| 2010 |
Hain D, Bettencourt BR, Okamura K, Csorba T, Meyer W, Jin Z, Biggerstaff J, Siomi H, Hutvagner G, Lai EC, Welte M, Müller HA. Natural variation of the amino-terminal glutamine-rich domain in Drosophila argonaute2 is not associated with developmental defects. Plos One. 5: e15264. PMID 21253006 DOI: 10.1371/Journal.Pone.0015264 |
0.583 |
|
| 2010 |
Yao J, Hennessey T, Flynt A, Lai E, Beal MF, Lin MT. MicroRNA-related cofilin abnormality in Alzheimer's disease. Plos One. 5: e15546. PMID 21179570 DOI: 10.1371/Journal.Pone.0015546 |
0.667 |
|
| 2010 |
Roy S, Ernst J, Kharchenko PV, Kheradpour P, Negre N, Eaton ML, Landolin JM, Bristow CA, Ma L, Lin MF, Washietl S, Arshinoff BI, Ay F, Meyer PE, ... ... Lai EC, et al. Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science (New York, N.Y.). 330: 1787-97. PMID 21177974 DOI: 10.1126/Science.1198374 |
0.797 |
|
| 2010 |
Yang JS, Lai EC. Dicer-independent, Ago2-mediated microRNA biogenesis in vertebrates. Cell Cycle (Georgetown, Tex.). 9: 4455-60. PMID 21088485 DOI: 10.4161/cc.9.22.13958 |
0.394 |
|
| 2010 |
Rouget C, Papin C, Boureux A, Meunier AC, Franco B, Robine N, Lai EC, Pelisson A, Simonelig M. Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo. Nature. 467: 1128-32. PMID 20953170 DOI: 10.1038/Nature09465 |
0.666 |
|
| 2010 |
Yang JS, Maurin T, Robine N, Rasmussen KD, Jeffrey KL, Chandwani R, Papapetrou EP, Sadelain M, O'Carroll D, Lai EC. Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 15163-8. PMID 20699384 DOI: 10.1073/Pnas.1006432107 |
0.722 |
|
| 2010 |
Flynt AS, Greimann JC, Chung WJ, Lima CD, Lai EC. MicroRNA biogenesis via splicing and exosome-mediated trimming in Drosophila. Molecular Cell. 38: 900-7. PMID 20620959 DOI: 10.1016/J.Molcel.2010.06.014 |
0.764 |
|
| 2010 |
Okamura K, Lai EC. A deathly DNase activity for dicer. Developmental Cell. 18: 692-4. PMID 20493803 DOI: 10.1016/J.Devcel.2010.05.004 |
0.488 |
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| 2010 |
Büssing I, Yang JS, Lai EC, Grohans H. The nuclear export receptor XPO-1 supports primary miRNA processing in C. elegans and Drosophila Embo Journal. 29: 1830-1839. PMID 20436454 DOI: 10.1038/emboj.2010.82 |
0.419 |
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| 2010 |
Smibert P, Lai EC. A view from Drosophila: multiple biological functions for individual microRNAs. Seminars in Cell & Developmental Biology. 21: 745-53. PMID 20211749 DOI: 10.1016/J.Semcdb.2010.03.001 |
0.751 |
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| 2010 |
Berezikov E, Liu N, Flynt AS, Hodges E, Rooks M, Hannon GJ, Lai EC. Evolutionary flux of canonical microRNAs and mirtrons in Drosophila. Nature Genetics. 42: 6-9; author reply 9-. PMID 20037610 DOI: 10.1038/Ng0110-6 |
0.724 |
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| 2010 |
Bejarano F, Smibert P, Lai EC. miR-9a prevents apoptosis during wing development by repressing Drosophila LIM-only. Developmental Biology. 338: 63-73. PMID 19944676 DOI: 10.1016/J.Ydbio.2009.11.025 |
0.681 |
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| 2009 |
Robine N, Lau NC, Balla S, Jin Z, Okamura K, Kuramochi-Miyagawa S, Blower MD, Lai EC. A broadly conserved pathway generates 3'UTR-directed primary piRNAs. Current Biology : Cb. 19: 2066-76. PMID 20022248 DOI: 10.1016/J.Cub.2009.11.064 |
0.76 |
|
| 2009 |
Okamura K, Lai EC. [Diversity and complexity of dicer dependent small RNA networks in animals]. Seikagaku. the Journal of Japanese Biochemical Society. 81: 904-9. PMID 19928532 |
0.548 |
|
| 2009 |
Okamura K, Liu N, Lai EC. Distinct mechanisms for microRNA strand selection by Drosophila Argonautes. Molecular Cell. 36: 431-44. PMID 19917251 DOI: 10.1016/J.Molcel.2009.09.027 |
0.679 |
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| 2009 |
Lau NC, Robine N, Martin R, Chung WJ, Niki Y, Berezikov E, Lai EC. Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line. Genome Research. 19: 1776-85. PMID 19541914 DOI: 10.1101/Gr.094896.109 |
0.687 |
|
| 2009 |
Flynt A, Liu N, Martin R, Lai EC. Dicing of viral replication intermediates during silencing of latent Drosophila viruses. Proceedings of the National Academy of Sciences of the United States of America. 106: 5270-5. PMID 19251644 DOI: 10.1073/Pnas.0813412106 |
0.649 |
|
| 2009 |
Martin R, Smibert P, Yalcin A, Tyler DM, Schäfer U, Tuschl T, Lai EC. A Drosophila pasha mutant distinguishes the canonical microRNA and mirtron pathways. Molecular and Cellular Biology. 29: 861-70. PMID 19047376 DOI: 10.1128/Mcb.01524-08 |
0.768 |
|
| 2008 |
Flynt AS, Lai EC. Biological principles of microRNA-mediated regulation: shared themes amid diversity. Nature Reviews. Genetics. 9: 831-42. PMID 18852696 DOI: 10.1038/nrg2455 |
0.714 |
|
| 2008 |
Okamura K, Balla S, Martin R, Liu N, Lai EC. Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogaster. Nature Structural & Molecular Biology. 15: 998. PMID 18769470 DOI: 10.1038/nsmb0908-998c |
0.544 |
|
| 2008 |
Okamura K, Chung WJ, Lai EC. The long and short of inverted repeat genes in animals: microRNAs, mirtrons and hairpin RNAs. Cell Cycle (Georgetown, Tex.). 7: 2840-5. PMID 18769156 DOI: 10.4161/Cc.7.18.6734 |
0.691 |
|
| 2008 |
Okamura K, Lai EC. Endogenous small interfering RNAs in animals. Nature Reviews. Molecular Cell Biology. 9: 673-8. PMID 18719707 DOI: 10.1038/Nrm2479 |
0.59 |
|
| 2008 |
Smibert P, Lai EC. Lessons from microRNA mutants in worms, flies and mice. Cell Cycle (Georgetown, Tex.). 7: 2500-8. PMID 18719388 DOI: 10.4161/Cc.7.16.6454 |
0.745 |
|
| 2008 |
Liu N, Okamura K, Tyler DM, Phillips MD, Chung WJ, Lai EC. The evolution and functional diversification of animal microRNA genes. Cell Research. 18: 985-96. PMID 18711447 DOI: 10.1038/Cr.2008.278 |
0.677 |
|
| 2008 |
Hagen JW, Lai EC. MicroRNA control of cell-cell signaling during development and disease Cell Cycle. 7: 2327-2332. PMID 18677099 |
0.417 |
|
| 2008 |
Chung WJ, Okamura K, Martin R, Lai EC. Endogenous RNA interference provides a somatic defense against Drosophila transposons. Current Biology : Cb. 18: 795-802. PMID 18501606 DOI: 10.1016/J.Cub.2008.05.006 |
0.591 |
|
| 2008 |
Okamura K, Balla S, Martin R, Liu N, Lai EC. Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogaster. Nature Structural & Molecular Biology. 15: 581-90. PMID 18500351 DOI: 10.1038/Nsmb.1438 |
0.584 |
|
| 2008 |
Okamura K, Chung WJ, Ruby JG, Guo H, Bartel DP, Lai EC. The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs. Nature. 453: 803-6. PMID 18463630 DOI: 10.1038/Nature07015 |
0.6 |
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| 2008 |
Okamura K, Phillips MD, Tyler DM, Duan H, Chou YT, Lai EC. The regulatory activity of microRNA* species has substantial influence on microRNA and 3' UTR evolution. Nature Structural & Molecular Biology. 15: 354-63. PMID 18376413 DOI: 10.1038/Nsmb.1409 |
0.675 |
|
| 2008 |
Cayirlioglu P, Kadow IG, Zhan X, Okamura K, Suh GS, Gunning D, Lai EC, Zipursky SL. Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems. Science (New York, N.Y.). 319: 1256-60. PMID 18309086 DOI: 10.1126/Science.1149483 |
0.506 |
|
| 2008 |
Tyler DM, Okamura K, Chung WJ, Hagen JW, Berezikov E, Hannon GJ, Lai EC. Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci. Genes & Development. 22: 26-36. PMID 18172163 DOI: 10.1101/Gad.1615208 |
0.679 |
|
| 2007 |
Stark A, Lin MF, Kheradpour P, Pedersen JS, Parts L, Carlson JW, Crosby MA, Rasmussen MD, Roy S, Deoras AN, Ruby JG, Brennecke J, Hodges E, ... ... Lai EC, et al. Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature. 450: 219-32. PMID 17994088 DOI: 10.1038/Nature06340 |
0.37 |
|
| 2007 |
Ruby JG, Stark A, Johnston WK, Kellis M, Bartel DP, Lai EC. Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs. Genome Research. 17: 1850-64. PMID 17989254 DOI: 10.1101/Gr.6597907 |
0.437 |
|
| 2007 |
Silver SJ, Hagen JW, Okamura K, Perrimon N, Lai EC. Functional screening identifies miR-315 as a potent activator of Wingless signaling. Proceedings of the National Academy of Sciences of the United States of America. 104: 18151-6. PMID 17989227 DOI: 10.1073/Pnas.0706673104 |
0.661 |
|
| 2007 |
Berezikov E, Chung WJ, Willis J, Cuppen E, Lai EC. Mammalian Mirtron Genes Molecular Cell. 28: 328-336. PMID 17964270 DOI: 10.1016/j.molcel.2007.09.028 |
0.362 |
|
| 2007 |
Okamura K, Hagen JW, Duan H, Tyler DM, Lai EC. The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. Cell. 130: 89-100. PMID 17599402 DOI: 10.1016/J.Cell.2007.06.028 |
0.684 |
|
| 2005 |
Aboobaker AA, Tomancak P, Patel N, Rubin GM, Lai EC. Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development. Proceedings of the National Academy of Sciences of the United States of America. 102: 18017-22. PMID 16330759 DOI: 10.1073/Pnas.0508823102 |
0.756 |
|
| 2005 |
Lai EC. miRNAs: Whys and wherefores of miRNA-mediated regulation Current Biology. 15: R458-R460. PMID 15964265 DOI: 10.1016/j.cub.2005.06.015 |
0.407 |
|
| 2005 |
Lai EC, Tam B, Rubin GM. Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs. Genes & Development. 19: 1067-80. PMID 15833912 DOI: 10.1101/gad.1291905 |
0.626 |
|
| 2005 |
Lai EC, Roegiers F, Qin X, Jan YN, Rubin GM. The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta. Development (Cambridge, England). 132: 2319-32. PMID 15829515 DOI: 10.1242/dev.01825 |
0.444 |
|
| 2004 |
Lai EC, Wiel C, Rubin GM. Complementary miRNA pairs suggest a regulatory role for miRNA:miRNA duplexes. Rna (New York, N.Y.). 10: 171-5. PMID 14730015 DOI: 10.1261/rna.5191904 |
0.615 |
|
| 2003 |
Lai EC, Tomancak P, Williams RW, Rubin GM. Computational identification of Drosophila microRNA genes. Genome Biology. 4: R42. PMID 12844358 DOI: 10.1186/gb-2003-4-7-r42 |
0.765 |
|
| 2001 |
Lai EC, Deblandre GA, Kintner C, Rubin GM. Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta. Developmental Cell. 1: 783-94. PMID 11740940 DOI: 10.1016/S1534-5807(01)00092-2 |
0.455 |
|
| 2001 |
Lai EC, Rubin GM. Neuralized is essential for a subset of Notch pathway-dependent cell fate decisions during Drosophila eye development. Proceedings of the National Academy of Sciences of the United States of America. 98: 5637-42. PMID 11344304 DOI: 10.1073/pnas.101135498 |
0.435 |
|
| 2001 |
Lai EC, Rubin GM. neuralized functions cell-autonomously to regulate a subset of notch-dependent processes during adult Drosophila development. Developmental Biology. 231: 217-33. PMID 11180964 DOI: 10.1006/dbio.2000.0124 |
0.455 |
|
| 2000 |
Lai EC, Bodner R, Posakony JW. The enhancer of split complex of Drosophila includes four Notch-regulated members of the bearded gene family. Development (Cambridge, England). 127: 3441-55. PMID 10903170 |
0.586 |
|
| 2000 |
Lai EC, Bodner R, Kavaler J, Freschi G, Posakony JW. Antagonism of notch signaling activity by members of a novel protein family encoded by the bearded and enhancer of split gene complexes. Development (Cambridge, England). 127: 291-306. PMID 10603347 |
0.599 |
|
| 1999 |
Nellesen DT, Lai EC, Posakony JW. Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators. Developmental Biology. 213: 33-53. PMID 10452845 DOI: 10.1006/dbio.1999.9324 |
0.616 |
|
| 1998 |
Lai EC, Burks C, Posakony JW. The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts. Development (Cambridge, England). 125: 4077-88. PMID 9735368 |
0.616 |
|
| 1998 |
Lai EC, Posakony JW. Regulation of Drosophila neurogenesis by RNA:RNA duplexes? Cell. 93: 1103-4. PMID 9657143 DOI: 10.1016/S0092-8674(00)81454-3 |
0.618 |
|
| 1997 |
Lai EC, Posakony JW. The Bearded box, a novel 3' UTR sequence motif, mediates negative post-transcriptional regulation of Bearded and Enhancer of split Complex gene expression. Development (Cambridge, England). 124: 4847-56. PMID 9428421 |
0.638 |
|
| 1997 |
Leviten MW, Lai EC, Posakony JW. The Drosophila gene Bearded encodes a novel small protein and shares 3' UTR sequence motifs with multiple Enhancer of split complex genes. Development (Cambridge, England). 124: 4039-51. PMID 9374401 |
0.63 |
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