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Hans D. Brightbill, Ph.D. - Publications

Affiliations: 
2000 University of California, Los Angeles, Los Angeles, CA 
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21 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Corzo CA, Varfolomeev E, Setiadi AF, Francis R, Klabunde S, Senger K, Sujatha-Bhaskar S, Drobnick J, Do S, Suto E, Huang Z, Eastham-Anderson J, Katewa A, Pang J, Domeyer M, ... ... Brightbill HD, et al. The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells. Science Signaling. 13. PMID 32487715 DOI: 10.1126/Scisignal.Aaz1053  0.483
2020 Rajapaksa NS, Gobbi A, Drobnick J, Do S, Kolesnikov A, Liang J, Chen Y, Sujatha-Bhaskar S, Huang Z, Brightbill H, Francis R, Yu C, Choo EF, DeMent K, Ran Y, et al. Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity. Acs Medicinal Chemistry Letters. 11: 327-333. PMID 32184965 DOI: 10.1021/Acsmedchemlett.9B00380  0.383
2018 Jie Z, Yang JY, Gu M, Wang H, Xie X, Li Y, Liu T, Zhu L, Shi J, Zhang L, Zhou X, Joo D, Brightbill HD, Cong Y, Lin D, et al. NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis. Nature Immunology. PMID 30250187 DOI: 10.1038/S41590-018-0206-Z  0.46
2018 Blaquiere N, Castanedo G, Burch J, Berezhkovskiy L, Brightbill H, Brown S, Chan C, Chiang PC, Crawford JJ, Dong T, Fan P, Feng J, Ghilardi N, Godemann R, Gogol E, et al. A scaffold-hopping approach to discover potent, selective and efficacious inhibitors of NF-κB inducing kinase. Journal of Medicinal Chemistry. PMID 29940120 DOI: 10.1021/Acs.Jmedchem.8B00678  0.383
2018 Brightbill HD, Suto E, Blaquiere N, Ramamoorthi N, Sujatha-Bhaskar S, Gogol EB, Castanedo GM, Jackson BT, Kwon YC, Haller S, Lesch J, Bents K, Everett C, Kohli PB, Linge S, et al. NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus. Nature Communications. 9: 179. PMID 29330524 DOI: 10.1038/S41467-017-02672-0  0.37
2016 Castanedo GM, Blaquiere N, Beresini MH, Bravo B, Brightbill H, Chen J, Cui H, Eigenbrot C, Everett C, Feng JA, Godemann R, Gogol E, Hymowitz SG, Johnson AR, Kayagaki N, et al. Structure-based design of tricyclic NF-κB inducing kinase (NIK) inhibitors that have high selectivity over phosphoinositide-3-kinase (PI3K). Journal of Medicinal Chemistry. PMID 28005357 DOI: 10.1021/Acs.Jmedchem.6B01363  0.324
2016 Li Y, Wang H, Zhou X, Xie X, Chen X, Jie Z, Zou Q, Hu H, Zhu L, Cheng X, Brightbill HD, Wu LC, Wang L, Sun SC. Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses. Scientific Reports. 6: 22115. PMID 26912039 DOI: 10.1038/Srep22115  0.384
2015 Katakam AK, Brightbill H, Franci C, Kung C, Nunez V, Jones C, Peng I, Jeet S, Wu LC, Mellman I, Delamarre L, Austin CD. Dendritic cells require NIK for CD40-dependent cross-priming of CD8+ T cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 26561586 DOI: 10.1073/Pnas.1520627112  0.384
2015 Brightbill HD, Jackman JK, Suto E, Kennedy H, Jones C, Chalasani S, Lin Z, Tam L, Roose-Girma M, Balazs M, Austin CD, Lee WP, Wu LC. Conditional Deletion of NF-κB-Inducing Kinase (NIK) in Adult Mice Disrupts Mature B Cell Survival and Activation. Journal of Immunology (Baltimore, Md. : 1950). PMID 26116508 DOI: 10.4049/Jimmunol.1401514  0.36
2014 Simpson LJ, Patel S, Bhakta NR, Choy DF, Brightbill HD, Ren X, Wang Y, Pua HH, Baumjohann D, Montoya MM, Panduro M, Remedios KA, Huang X, Fahy JV, Arron JR, et al. A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production. Nature Immunology. 15: 1162-70. PMID 25362490 DOI: 10.1038/Ni.3026  0.304
2013 Talay O, Yan D, Brightbill HD, Straney EE, Zhou M, Ladi E, Lee WP, Egen JG, Austin CD, Xu M, Wu LC. Addendum: IgE+ memory B cells and plasma cells generated through a germinal-center pathway. Nature Immunology. 14: 1302-4. PMID 24240161 DOI: 10.1038/Ni.2770  0.306
2012 Talay O, Yan D, Brightbill HD, Straney EE, Zhou M, Ladi E, Lee WP, Egen JG, Austin CD, Xu M, Wu LC. IgE⁺ memory B cells and plasma cells generated through a germinal-center pathway. Nature Immunology. 13: 396-404. PMID 22366892 DOI: 10.1038/Ni.2256  0.326
2012 Talay O, Yan D, Brightbill HD, Straney EEM, Zhou M, Ladi E, Lee WP, Egen JG, Austin CD, Xu M, Wu LC. Reply to "On the differentiation of mouse IgE + cells" Nature Immunology. 13: 623-624. DOI: 10.1038/Ni.2323  0.312
2010 Brightbill HD, Jeet S, Lin Z, Yan D, Zhou M, Tan M, Nguyen A, Yeh S, Delarosa D, Leong SR, Wong T, Chen Y, Ultsch M, Luis E, Ramani SR, et al. Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice. The Journal of Clinical Investigation. 120: 2218-29. PMID 20458139 DOI: 10.1172/Jci40141  0.322
2002 Kim J, Ochoa MT, Krutzik SR, Takeuchi O, Uematsu S, Legaspi AJ, Brightbill HD, Holland D, Cunliffe WJ, Akira S, Sieling PA, Godowski PJ, Modlin RL. Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. Journal of Immunology (Baltimore, Md. : 1950). 169: 1535-41. PMID 12133981 DOI: 10.4049/Jimmunol.169.3.1535  0.448
2000 Brightbill HD, Modlin RL. Toll-like receptors: molecular mechanisms of the mammalian immune response. Immunology. 101: 1-10. PMID 11012747 DOI: 10.1046/J.1365-2567.2000.00093.X  0.356
2000 Yamauchi PS, Bleharski JR, Uyemura K, Kim J, Sieling PA, Miller A, Brightbill H, Schlienger K, Rea TH, Modlin RL. A role for CD40-CD40 ligand interactions in the generation of type 1 cytokine responses in human leprosy. Journal of Immunology (Baltimore, Md. : 1950). 165: 1506-12. PMID 10903757 DOI: 10.4049/Jimmunol.165.3.1506  0.371
2000 Brightbill HD, Plevy SE, Modlin RL, Smale ST. A prominent role for Sp1 during lipopolysaccharide-mediated induction of the IL-10 promoter in macrophages. Journal of Immunology (Baltimore, Md. : 1950). 164: 1940-51. PMID 10657644 DOI: 10.4049/Jimmunol.164.4.1940  0.52
1999 Brightbill HD, Libraty DH, Krutzik SR, Yang RB, Belisle JT, Bleharski JR, Maitland M, Norgard MV, Plevy SE, Smale ST, Brennan PJ, Bloom BR, Godowski PJ, Modlin RL. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science (New York, N.Y.). 285: 732-6. PMID 10426995 DOI: 10.1126/Science.285.5428.732  0.548
1999 Modlin RL, Brightbill HD, Godowski PJ. The toll of innate immunity on microbial pathogens. The New England Journal of Medicine. 340: 1834-5. PMID 10362831 DOI: 10.1056/Nejm199906103402312  0.342
1998 Brightbill HD, Smale ST, Modlin RL. A single control element mediates the activation of the IL-10 promoter: A role for Sp1 in mediating LPS induction of IL-10 gene expression in macrophages Faseb Journal. 12: A1064.  0.325
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