| Year |
Citation |
Score |
| 2020 |
Moritz AE, Free RB, Weiner WS, Akano EO, Gandhi D, Abramyan A, Keck TM, Ferrer M, Hu X, Southall N, Steiner J, Aubé J, Shi L, Frankowski KJ, Sibley DR. Discovery, Optimization and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist. Journal of Medicinal Chemistry. PMID 32342685 DOI: 10.1021/Acs.Jmedchem.0C00424 |
0.364 |
|
| 2020 |
Zhou H, Blevins MA, Hsu JY, Kong D, Galbraith MD, Goodspeed A, Culp-Hill R, Oliphant MU, Ramirez D, Zhang L, Pineiro JT, Mathews Griner L, King R, Barnaeva E, Hu X, ... Southall NT, et al. A SIX1/EYA2 small molecule inhibitor disrupts EMT and metastasis. Cancer Research. PMID 32341035 DOI: 10.1158/0008-5472.Can-20-0435 |
0.316 |
|
| 2020 |
Dextras C, Dashnyam M, Griner LAM, Sundaresan J, Chim B, Yu Z, Vodnala S, Lee CR, Hu X, Southall N, Marugan JJ, Jadhav A, Restifo NP, Acquavella N, Ferrer M, et al. Identification of Small Molecule Enhancers of Immunotherapy for Melanoma. Scientific Reports. 10: 5688. PMID 32231230 DOI: 10.1038/S41598-020-62369-1 |
0.39 |
|
| 2020 |
Kapoor A, Ghosh AK, Forman M, Hu X, Ye W, Southall N, Marugan JJ, Keyes RF, Smith BC, Meyers DJ, Ferrer M, Arav-Boger R. Validation and characterization of five distinct novel inhibitors of human cytomegalovirus. Journal of Medicinal Chemistry. PMID 32191456 DOI: 10.1021/Acs.Jmedchem.9B01501 |
0.393 |
|
| 2020 |
Sheils T, Mathias SL, Siramshetty VB, Bocci G, Bologa CG, Yang JJ, Waller A, Southall N, Nguyen DT, Oprea TI. How to Illuminate the Druggable Genome Using Pharos. Current Protocols in Bioinformatics. 69: e92. PMID 31898878 DOI: 10.1002/Cpbi.92 |
0.304 |
|
| 2020 |
Shah P, Siramshetty VB, Zakharov AV, Southall NT, Xu X, Nguyen D. Predicting liver cytosol stability of small molecules Journal of Cheminformatics. 12. DOI: 10.1186/S13321-020-00426-7 |
0.354 |
|
| 2019 |
Kaftanovskaya EM, Ng HH, Soula M, Rivas B, Myhr C, Ho BA, Cervantes BA, Shupe TD, Devarasetty M, Hu X, Xu X, Patnaik S, Wilson KJ, Barnaeva E, Ferrer M, ... Southall NT, et al. Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201901046R. PMID 31419161 DOI: 10.1096/Fj.201901046R |
0.304 |
|
| 2019 |
Huang R, Grishagin I, Wang Y, Zhao T, Greene J, Obenauer JC, Ngan D, Nguyen DT, Guha R, Jadhav A, Southall N, Simeonov A, Austin CP. The NCATS BioPlanet - An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics. Frontiers in Pharmacology. 10: 445. PMID 31133849 DOI: 10.3389/Fphar.2019.00445 |
0.308 |
|
| 2019 |
Sengupta N, Jović M, Barnaeva E, Kim DW, Hu X, Southall N, Dejmek M, Mejdrova I, Nencka R, Baumlova A, Chalupska D, Boura E, Ferrer M, Marugan J, Balla T. A large scale high throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha. Journal of Lipid Research. PMID 30626625 DOI: 10.1194/Jlr.D090159 |
0.365 |
|
| 2018 |
Chiang N, Barnaeva E, Hu X, Marugan J, Southall N, Ferrer M, Serhan CN. Identification of Chemotype Agonists for Human Resolvin D1 Receptor DRV1 with Pro-Resolving Functions. Cell Chemical Biology. PMID 30554914 DOI: 10.1016/J.Chembiol.2018.10.023 |
0.343 |
|
| 2018 |
Luderman KD, Conroy JL, Free RB, Southall N, Ferrer M, Sanchez-Soto M, Moritz AE, Willette BKA, Fyfe TJ, Jain P, Titus S, Hazelwood LA, Aube J, Lane JR, Frankowski KJ, et al. Identification of positive allosteric modulators of the D1 dopamine receptor that act at diverse binding sites. Molecular Pharmacology. PMID 30068735 DOI: 10.1124/Mol.118.113175 |
0.356 |
|
| 2018 |
Wilson KJ, Xiao J, Chen CZ, Huang Z, Agoulnik IU, Ferrer M, Southall N, Hu X, Zheng W, Xu X, Wang A, Myhr C, Barnaeva E, George ER, Agoulnik AI, et al. Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile. European Journal of Medicinal Chemistry. 156: 79-92. PMID 30006176 DOI: 10.1016/J.Ejmech.2018.06.008 |
0.352 |
|
| 2018 |
Datta A, Kim H, McGee L, Johnson AE, Talwar S, Marugan J, Southall N, Hu X, Lal M, Mondal D, Ferrer M, Abdel-Mageed AB. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Scientific Reports. 8: 8161. PMID 29802284 DOI: 10.1038/S41598-018-26411-7 |
0.403 |
|
| 2018 |
Frankowski KJ, Wang C, Patnaik S, Schoenen FJ, Southall N, Li D, Teper Y, Sun W, Kandela I, Hu D, Dextras C, Knotts Z, Bian Y, Norton J, Titus S, et al. Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis. Science Translational Medicine. 10. PMID 29769289 DOI: 10.1126/Scitranslmed.Aap8307 |
0.342 |
|
| 2017 |
Al-Ramahi I, Giridharan SSP, Chen YC, Patnaik S, Safren N, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada S, ... ... Southall N, et al. Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein. Elife. 6. PMID 29256861 DOI: 10.7554/Elife.29123 |
0.347 |
|
| 2017 |
Neumann S, Eliseeva E, Boutin A, Barnaeva E, Ferrer M, Southall N, Kim D, Hu X, Morgan SJ, Marugan JJ, Gershengorn MC. Discovery of a Positive Allosteric Modulator of the TSH Receptor: Potentiation of TSH-mediated Preosteoblast Differentiation In Vitro. The Journal of Pharmacology and Experimental Therapeutics. PMID 29089368 DOI: 10.1124/Jpet.117.244095 |
0.316 |
|
| 2017 |
Huang BX, Newcomer K, Kevala K, Barnaeva E, Zheng W, Hu X, Patnaik S, Southall N, Marugan J, Ferrer M, Kim HY. Identification of 4-phenylquinolin-2(1H)-one as a specific allosteric inhibitor of Akt. Scientific Reports. 7: 11673. PMID 28916818 DOI: 10.1038/S41598-017-11870-1 |
0.33 |
|
| 2017 |
Hamilton DH, Mathews-Griner L, Keller JM, Hu X, Southall N, Marugan J, David JM, Ferrer F, Schlom J, Palena C. Abstract B64: A high-throughput screen identifies fulvestrant as an enhancer of immune-mediated cytotoxicity of mesenchymal-like lung cancer cells Cancer Immunology Research. 5. DOI: 10.1158/2326-6074.Tumimm16-B64 |
0.312 |
|
| 2016 |
Sun H, Huang R, Xia M, Shahane S, Southall N, Wang Y. Prediction of hERG Liability - Using SVM Classification, Bootstrapping and Jackknifing. Molecular Informatics. PMID 28000393 DOI: 10.1002/Minf.201600126 |
0.329 |
|
| 2016 |
Sun W, Weingarten RA, Xu M, Southall N, Dai S, Shinn P, Sanderson PE, Williamson PR, Frank KM, Zheng W. Rapid antimicrobial susceptibility test for identification of new therapeutics and drug combinations against multidrug-resistant bacteria. Emerging Microbes & Infections. 5: e116. PMID 27826141 DOI: 10.1038/Emi.2016.123 |
0.332 |
|
| 2016 |
Wang L, Xu M, Southall N, Zheng W, Wang S. A High-Throughput Assay for Developing Inhibitors of PhoP, A Virulence Factor of Mycobacterium tuberculosis. Combinatorial Chemistry & High Throughput Screening. PMID 27748178 DOI: 10.2174/1386207319666161010163249 |
0.344 |
|
| 2016 |
Wang M, Xu M, Long Y, Fargue S, Southall N, Hu X, McKew JC, Danpure CJ, Zheng W. High throughput cell-based assay for identification of glycolate oxidase inhibitors as a potential treatment for Primary Hyperoxaluria Type 1. Scientific Reports. 6: 34060. PMID 27670739 DOI: 10.1038/Srep34060 |
0.402 |
|
| 2016 |
Jang DS, Ye W, Guimei T, Solomon M, Southall N, Hu X, Marugan J, Ferrer M, Maegawa GH. Cell-based high-throughput screening identifies galactocerebrosidase enhancers as potential small-molecule therapies for Krabbe's disease. Journal of Neuroscience Research. 94: 1231-45. PMID 27638606 DOI: 10.1002/Jnr.23875 |
0.406 |
|
| 2016 |
Mukhopadhyay R, Roy S, Venkatadri R, Su YP, Ye W, Barnaeva E, Mathews Griner L, Southall N, Hu X, Wang AQ, Xu X, Dulcey AE, Marugan JJ, Ferrer M, Arav-Boger R. Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus. Plos Pathogens. 12: e1005717. PMID 27336364 DOI: 10.1371/Journal.Ppat.1005717 |
0.321 |
|
| 2016 |
Hamilton DH, Matthews Griner L, Keller JM, Hu X, Southall N, Marugan J, David JM, Ferrer M, Palena C. Targeting estrogen receptor signaling with fulvestrant enhances immune and chemotherapy-mediated cytotoxicity of human lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27267852 DOI: 10.1158/1078-0432.Ccr-15-3059 |
0.305 |
|
| 2016 |
Thorne N, Malik N, Shah S, Zhao J, Class B, Aguisanda F, Southall N, Xia M, McKew JC, Rao M, Zheng W. High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress. Stem Cells Translational Medicine. PMID 27034412 DOI: 10.5966/Sctm.2015-0170 |
0.352 |
|
| 2016 |
Liao XH, Meena NP, Southall N, Liu L, Swaroop M, Zhang AL, Xiang JJ, Parent CA, Zheng W, Kimmel AR. A High-Throughput, Multi-Cell Phenotype Assay for the Identification of Novel Inhibitors of Chemotaxis/Migration. Scientific Reports. 6: 22273. PMID 26956526 DOI: 10.1038/Srep22273 |
0.423 |
|
| 2016 |
Hu X, Myhr C, Huang Z, Xiao J, Barnaeva E, Ho BA, Agoulnik IU, Ferrer M, Marugan JJ, Southall N, Agoulnik AI. Structural insights into the activation of human relaxin family peptide receptor 1 by small molecule agonists. Biochemistry. PMID 26866459 DOI: 10.1021/Acs.Biochem.5B01195 |
0.352 |
|
| 2016 |
Luderman KD, Conroy JL, Free RB, Southall NT, Ferrer M, Aubé J, Frankowski KJ, Sibley DR. Structurally Diverse Positive Allosteric Modulators of the D1 Dopamine Receptor Potentiate G‐Protein and β‐Arrestin‐Mediated Signaling The Faseb Journal. 30. DOI: 10.1096/Fasebj.30.1_Supplement.931.9 |
0.354 |
|
| 2015 |
Bernstock JD, Lee YJ, Peruzzotti-Jametti L, Southall N, Johnson KR, Maric D, Volpe G, Kouznetsova J, Zheng W, Pluchino S, Hallenbeck JM. A novel quantitative high-throughput screen identifies drugs that both activate SUMO conjugation via the inhibition of microRNAs 182 and 183 and facilitate neuroprotection in a model of oxygen and glucose deprivation. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26661196 DOI: 10.1177/0271678X15609939 |
0.352 |
|
| 2015 |
Hu Z, Hu X, He S, Yim HJ, Xiao J, Swaroop M, Tanega C, Zhang YQ, Yi G, Kao CC, Marugan J, Ferrer M, Zheng W, Southall N, Liang TJ. Identification of Novel Anti-Hepatitis C Virus Agents by a Quantitative High Throughput Screen in a Cell-Based Infection Assay. Antiviral Research. PMID 26515788 DOI: 10.1016/J.Antiviral.2015.10.018 |
0.314 |
|
| 2015 |
He S, Jain P, Lin B, Ferrer M, Hu Z, Southall N, Hu X, Zheng W, Neuenswander B, Cho CH, Chen Y, Worlikar SA, Aubé J, Larock RC, Schoenen FJ, et al. High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors. Acs Combinatorial Science. PMID 26332742 DOI: 10.1021/Acscombsci.5B00101 |
0.374 |
|
| 2015 |
Lee JA, Shinn P, Jaken S, Oliver S, Willard FS, Heidler S, Peery RB, Oler J, Chu S, Southall N, Dexheimer TS, Smallwood J, Huang R, Guha R, Jadhav A, et al. Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays. Plos One. 10: e0130796. PMID 26177200 DOI: 10.1371/Journal.Pone.0130796 |
0.367 |
|
| 2015 |
Kumari D, Swaroop M, Southall N, Huang W, Zheng W, Usdin K. High-Throughput Screening to Identify Compounds That Increase Fragile X Mental Retardation Protein Expression in Neural Stem Cells Differentiated From Fragile X Syndrome Patient-Derived Induced Pluripotent Stem Cells. Stem Cells Translational Medicine. 4: 800-8. PMID 25999519 DOI: 10.5966/Sctm.2014-0278 |
0.336 |
|
| 2015 |
Blevins MA, Kouznetsova J, Krueger AB, King R, Griner LM, Hu X, Southall N, Marugan JJ, Zhang Q, Ferrer M, Zhao R. Small Molecule, NSC95397, Inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression. Journal of Biomolecular Screening. 20: 663-72. PMID 25477201 DOI: 10.1177/1087057114561400 |
0.363 |
|
| 2015 |
Class B, Thorne N, Aguisanda F, Southall N, McKew JC, Zheng W. High-throughput viability assay using an autonomously bioluminescent cell line with a bacterial Lux reporter. Journal of Laboratory Automation. 20: 164-74. PMID 25447977 DOI: 10.1177/2211068214560608 |
0.345 |
|
| 2015 |
Wang C, Frankowski K, Yaroslav T, Patnaik S, Schoenen F, Southall N, Sun W, Titus S, Griner L, Dextras C, Sultan J, Kandela I, Lewandowska M, Wen Y, Norton J, et al. Abstract 5368: Metarrestin effectively disassembles PNCs and inhibits metastasis Cancer Research. 75: 5368-5368. DOI: 10.1158/1538-7445.Am2015-5368 |
0.317 |
|
| 2014 |
Kulakova L, Galkin A, Chen CZ, Southall N, Marugan JJ, Zheng W, Herzberg O. Discovery of novel antigiardiasis drug candidates. Antimicrobial Agents and Chemotherapy. 58: 7303-11. PMID 25267663 DOI: 10.1128/Aac.03834-14 |
0.33 |
|
| 2014 |
Hu X, Legler PM, Southall N, Maloney DJ, Simeonov A, Jadhav A. Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening. Journal of Computer-Aided Molecular Design. 28: 765-78. PMID 24958623 DOI: 10.1007/S10822-014-9758-7 |
0.341 |
|
| 2014 |
Free RB, Chun LS, Moritz AE, Miller BN, Doyle TB, Conroy JL, Padron A, Meade JA, Xiao J, Hu X, Dulcey AE, Han Y, Duan L, Titus S, Bryant-Genevier M, ... ... Southall NT, et al. Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor. Molecular Pharmacology. 86: 96-105. PMID 24755247 DOI: 10.1124/Mol.113.090563 |
0.357 |
|
| 2014 |
Krueger AB, Drasin DJ, Lea WA, Patrick AN, Patnaik S, Backos DS, Matheson CJ, Hu X, Barnaeva E, Holliday MJ, Blevins MA, Robin TP, Eisenmesser EZ, Ferrer M, Simeonov A, ... Southall N, et al. Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration. The Journal of Biological Chemistry. 289: 16349-61. PMID 24755226 DOI: 10.1074/Jbc.M114.566729 |
0.392 |
|
| 2014 |
Bhattacharyya N, Hu X, Chen CZ, Mathews Griner LA, Zheng W, Inglese J, Austin CP, Marugan JJ, Southall N, Neumann S, Northup JK, Ferrer M, Collins MT. A high throughput screening assay system for the identification of small molecule inhibitors of gsp. Plos One. 9: e90766. PMID 24667240 DOI: 10.1371/Journal.Pone.0090766 |
0.387 |
|
| 2014 |
Sun W, Tanaka TQ, Magle CT, Huang W, Southall N, Huang R, Dehdashti SJ, McKew JC, Williamson KC, Zheng W. Chemical signatures and new drug targets for gametocytocidal drug development. Scientific Reports. 4: 3743. PMID 24434750 DOI: 10.1038/Srep03743 |
0.353 |
|
| 2014 |
Hu Z, Lan KH, He S, Swaroop M, Hu X, Southall N, Zheng W, Liang TJ. Novel cell-based hepatitis C virus infection assay for quantitative high-throughput screening of anti-hepatitis C virus compounds. Antimicrobial Agents and Chemotherapy. 58: 995-1004. PMID 24277038 DOI: 10.1128/Aac.02094-13 |
0.356 |
|
| 2014 |
Ketley A, Chen CZ, Li X, Arya S, Robinson TE, Granados-Riveron J, Udosen I, Morris GE, Holt I, Furling D, Chaouch S, Haworth B, Southall N, Shinn P, Zheng W, et al. High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines. Human Molecular Genetics. 23: 1551-62. PMID 24179176 DOI: 10.1093/Hmg/Ddt542 |
0.408 |
|
| 2014 |
Hu Z, Lan K, He S, Swaroop M, Hu X, Southall N, Zheng W, Liang TJ. Novel Cell-Based Hepatitis C Virus Infection Assay for Quantitative High-Throughput Screening of Anti-Hepatitis C Virus Compounds Antimicrobial Agents and Chemotherapy. 58: 2995-2995. DOI: 10.1128/Aac.02529-14 |
0.303 |
|
| 2013 |
Patnaik S, Marugan JJ, Liu K, Zheng W, Southall N, Dehdashti SJ, Thorsell A, Heilig M, Bell L, Zook M, Eskay B, Brimacombe KR, Austin CP. Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor. Journal of Medicinal Chemistry. 56: 9045-56. PMID 24171469 DOI: 10.1021/Jm400904M |
0.307 |
|
| 2013 |
Sun W, Park YD, Sugui JA, Fothergill A, Southall N, Shinn P, McKew JC, Kwon-Chung KJ, Zheng W, Williamson PR. Rapid Identification of Antifungal Compounds against Exserohilum rostratum Using High Throughput Drug Repurposing Screens Plos One. 8. PMID 23990907 DOI: 10.1371/Journal.Pone.0070506 |
0.375 |
|
| 2013 |
Rhyasen GW, Bolanos L, Fang J, Jerez A, Wunderlich M, Rigolino C, Mathews L, Ferrer M, Southall N, Guha R, Keller J, Thomas C, Beverly LJ, Cortelezzi A, Oliva EN, et al. Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome. Cancer Cell. 24: 90-104. PMID 23845443 DOI: 10.1016/J.Ccr.2013.05.006 |
0.33 |
|
| 2013 |
Childs-Disney JL, Stepniak-Konieczna E, Tran T, Yildirim I, Park H, Chen CZ, Hoskins J, Southall N, Marugan JJ, Patnaik S, Zheng W, Austin CP, Schatz GC, Sobczak K, Thornton CA, et al. Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules. Nature Communications. 4: 2044. PMID 23806903 DOI: 10.1038/Ncomms3044 |
0.302 |
|
| 2013 |
Casson L, Howell L, Mathews LA, Ferrer M, Southall N, Guha R, Keller JM, Thomas C, Siskind LJ, Beverly LJ. Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins. Plos One. 8: e54525. PMID 23342165 DOI: 10.1371/Journal.Pone.0054525 |
0.365 |
|
| 2013 |
Hu X, Vujanac M, Southall N, Erec Stebbins C. Inhibitors of the Yersinia protein tyrosine phosphatase through high throughput and virtual screening approaches Bioorganic and Medicinal Chemistry Letters. 23: 1056-1062. PMID 23294700 DOI: 10.1016/J.Bmcl.2012.12.018 |
0.38 |
|
| 2013 |
Chen CZ, Southall N, Xiao J, Marugan JJ, Ferrer M, Hu X, Jones RE, Feng S, Agoulnik IU, Zheng W, Agoulnik AI. Identification of small-molecule agonists of human relaxin family receptor 1 (RXFP1) by using a homogenous cell-based cAMP assay. Journal of Biomolecular Screening. 18: 670-7. PMID 23212924 DOI: 10.1177/1087057112469406 |
0.35 |
|
| 2013 |
Ribbens J, Whiteley G, Furuya H, Southall N, Hu X, Marugan J, Ferrer M, Maegawa GHB. A high-throughput screening assay using Krabbe disease patient cells Analytical Biochemistry. 434: 15-25. PMID 23138179 DOI: 10.1016/J.Ymgme.2012.11.159 |
0.355 |
|
| 2013 |
Krueger AB, Dehdashti SJ, Southall N, Marugan JJ, Ferrer M, Li X, Ford HL, Zheng W, Zhao R. Identification of a selective small-molecule inhibitor series targeting the eyes absent 2 (Eya2) phosphatase activity. Journal of Biomolecular Screening. 18: 85-96. PMID 22820394 DOI: 10.1177/1087057112453936 |
0.397 |
|
| 2012 |
Dandapani S, Rosse G, Southall N, Salvino JM, Thomas CJ. Selecting, Acquiring, and Using Small Molecule Libraries for High-Throughput Screening. Current Protocols in Chemical Biology. 4: 177-191. PMID 26705509 DOI: 10.1002/9780470559277.Ch110252 |
0.367 |
|
| 2012 |
Chen CZ, Southall N, Galkin A, Lim K, Marugan JJ, Kulakova L, Shinn P, van Leer D, Zheng W, Herzberg O. A homogenous luminescence assay reveals novel inhibitors for giardia lamblia carbamate kinase. Current Chemical Genomics. 6: 93-102. PMID 23400734 DOI: 10.2174/1875397301206010093 |
0.395 |
|
| 2012 |
Titus SA, Southall N, Marugan J, Austin CP, Zheng W. High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington's Disease Model. Current Chemical Genomics. 6: 79-86. PMID 23346268 DOI: 10.2174/1875397301206010079 |
0.324 |
|
| 2012 |
Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, ... ... Southall N, et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nature Chemical Biology. 8: 839-47. PMID 22922757 DOI: 10.1038/Nchembio.1060 |
0.326 |
|
| 2012 |
Cunningham L, Finckbeiner S, Hyde RK, Southall N, Marugan J, Yedavalli VR, Dehdashti SJ, Reinhold WC, Alemu L, Zhao L, Yeh JR, Sood R, Pommier Y, Austin CP, Jeang KT, et al. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction. Proceedings of the National Academy of Sciences of the United States of America. 109: 14592-7. PMID 22912405 DOI: 10.1073/Pnas.1200037109 |
0.357 |
|
| 2012 |
Xiao J, Westbroek W, Motabar O, Lea WA, Hu X, Velayati A, Zheng W, Southall N, Gustafson AM, Goldin E, Sidransky E, Liu K, Simeonov A, Tamargo RJ, Ribes A, et al. Discovery of a novel noniminosugar acid α glucosidase chaperone series. Journal of Medicinal Chemistry. 55: 7546-59. PMID 22834902 DOI: 10.1021/Jm3005543 |
0.322 |
|
| 2012 |
Xu M, Liu K, Southall N, Marugan JJ, Remaley AT, Zheng W. A high-throughput sphingomyelinase assay using natural substrate Analytical and Bioanalytical Chemistry. 404: 407-414. PMID 22710568 DOI: 10.1007/S00216-012-6174-5 |
0.395 |
|
| 2012 |
Patnaik S, Zheng W, Choi JH, Motabar O, Southall N, Westbroek W, Lea WA, Velayati A, Goldin E, Sidransky E, Leister W, Marugan JJ. Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase. Journal of Medicinal Chemistry. 55: 5734-48. PMID 22646221 DOI: 10.1021/Jm300063B |
0.388 |
|
| 2012 |
Marugan JJ, Huang W, Motabar O, Zheng W, Xiao J, Patnaik S, Southall N, Westbroek W, Lea WA, Simeonov A, Goldin E, Debernardi MA, Sidransky E. Non-iminosugar glucocerebrosidase small molecule chaperones. Medchemcomm. 3: 56-60. PMID 22606365 DOI: 10.1039/C1Md00200G |
0.355 |
|
| 2012 |
Goldin E, Zheng W, Motabar O, Southall N, Choi JH, Marugan J, Austin CP, Sidransky E. High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase. Plos One. 7: e29861. PMID 22272254 DOI: 10.1371/Journal.Pone.0029861 |
0.397 |
|
| 2012 |
Motabar O, Goldin E, Leister W, Liu K, Southall N, Huang W, Marugan JJ, Sidransky E, Zheng W. A high throughput glucocerebrosidase assay using the natural substrate glucosylceramide Analytical and Bioanalytical Chemistry. 402: 731-739. PMID 22033823 DOI: 10.1007/S00216-011-5496-Z |
0.373 |
|
| 2011 |
Englund EE, Neumann S, Eliseeva E, McCoy JG, Titus S, Zheng W, Southall N, Shin P, Leister W, Thomas CJ, Inglese J, Austin CP, Gershengorn MC, Huang W. The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists. Medchemcomm. 2: 1016-1020. PMID 22408719 DOI: 10.1039/C1Md00145K |
0.329 |
|
| 2011 |
Geng H, Whiteley G, Ribbens J, Zheng W, Southall N, Hu X, Marugan JJ, Ferrer M, Maegawa GH. Novel patient cell-based HTS assay for identification of small molecules for a lysosomal storage disease. Plos One. 6: e29504. PMID 22216298 DOI: 10.1371/Journal.Pone.0029504 |
0.363 |
|
| 2011 |
Xiao J, Marugan JJ, Zheng W, Titus S, Southall N, Cherry JJ, Evans M, Androphy EJ, Austin CP. Discovery, synthesis, and biological evaluation of novel SMN protein modulators. Journal of Medicinal Chemistry. 54: 6215-33. PMID 21819082 DOI: 10.1021/Jm200497T |
0.311 |
|
| 2011 |
Huang R, Southall N, Wang Y, Yasgar A, Shinn P, Jadhav A, Nguyen DT, Austin CP. The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics. Science Translational Medicine. 3: 80ps16. PMID 21525397 DOI: 10.1126/Scitranslmed.3001862 |
0.348 |
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| 2011 |
Xia M, Shahane SA, Huang R, Titus SA, Shum E, Zhao Y, Southall N, Zheng W, Witt KL, Tice RR, Austin CP. Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. Toxicology and Applied Pharmacology. 252: 250-8. PMID 21362439 DOI: 10.1016/J.Taap.2011.02.016 |
0.325 |
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| 2011 |
Marugan JJ, Zheng W, Motabar O, Southall N, Goldin E, Westbroek W, Stubblefield BK, Sidransky E, Aungst RA, Lea WA, Simeonov A, Leister W, Austin CP. Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. Journal of Medicinal Chemistry. 54: 1033-58. PMID 21250698 DOI: 10.1021/Jm1008902 |
0.377 |
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| 2011 |
Chen CZ, Kulakova L, Southall N, Marugan JJ, Galkin A, Austin CP, Herzberg O, Zheng W. High-throughput Giardia lamblia viability assay using bioluminescent ATP content measurements. Antimicrobial Agents and Chemotherapy. 55: 667-75. PMID 21078930 DOI: 10.1128/Aac.00618-10 |
0.381 |
|
| 2010 |
Motabar O, Liu K, Southall N, Marugan JJ, Goldin E, Sidransky E, Zheng W. High throughput screening for inhibitors of alpha-galactosidase. Current Chemical Genomics. 4: 67-73. PMID 21331308 DOI: 10.2174/1875397301004010067 |
0.393 |
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| 2010 |
Jiang JK, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorganic & Medicinal Chemistry Letters. 20: 3387-93. PMID 20451379 DOI: 10.1016/J.Bmcl.2010.04.015 |
0.309 |
|
| 2010 |
Boxer MB, Jiang JK, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Journal of Medicinal Chemistry. 53: 1048-55. PMID 20017496 DOI: 10.1021/Jm901577G |
0.324 |
|
| 2009 |
Veith H, Southall N, Huang R, James T, Fayne D, Artemenko N, Shen M, Inglese J, Austin CP, Lloyd DG, Auld DS. Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries. Nature Biotechnology. 27: 1050-5. PMID 19855396 DOI: 10.1038/Nbt.1581 |
0.363 |
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| 2009 |
Parham F, Austin C, Southall N, Huang R, Tice R, Portier C. Dose-response modeling of high-throughput screening data. Journal of Biomolecular Screening. 14: 1216-27. PMID 19828774 DOI: 10.1177/1087057109349355 |
0.36 |
|
| 2009 |
Huang R, Southall N, Xia M, Cho MH, Jadhav A, Nguyen DT, Inglese J, Tice RR, Austin CP. Weighted feature significance: a simple, interpretable model of compound toxicity based on the statistical enrichment of structural features. Toxicological Sciences : An Official Journal of the Society of Toxicology. 112: 385-93. PMID 19805409 DOI: 10.1093/Toxsci/Kfp231 |
0.32 |
|
| 2009 |
Wang Z, Zheng M, Li Z, Li R, Jia L, Xiong X, Southall N, Wang S, Xia M, Austin CP, Zheng W, Xie Z, Sun Y. Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition. Cancer Research. 69: 6556-64. PMID 19679550 DOI: 10.1158/0008-5472.Can-09-0891 |
0.304 |
|
| 2009 |
Johnson RL, Huang R, Jadhav A, Southall N, Wichterman J, MacArthur R, Xia M, Bi K, Printen J, Austin CP, Inglese J. A quantitative high-throughput screen for modulators of IL-6 signaling: a model for interrogating biological networks using chemical libraries. Molecular Biosystems. 5: 1039-50. PMID 19668870 DOI: 10.1039/B902021G |
0.382 |
|
| 2009 |
Neumann S, Huang W, Titus S, Krause G, Kleinau G, Alberobello AT, Zheng W, Southall NT, Inglese J, Austin CP, Celi FS, Gavrilova O, Thomas CJ, Raaka BM, Gershengorn MC. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 12471-6. PMID 19592511 DOI: 10.1073/Pnas.0904506106 |
0.322 |
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| 2009 |
Titus SA, Beacham D, Shahane SA, Southall N, Xia M, Huang R, Hooten E, Zhao Y, Shou L, Austin CP, Zheng W. A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel. Analytical Biochemistry. 394: 30-8. PMID 19583963 DOI: 10.1016/J.Ab.2009.07.003 |
0.37 |
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| 2009 |
Zhu PJ, Hobson JP, Southall N, Qiu C, Thomas CJ, Lu J, Inglese J, Zheng W, Leppla SH, Bugge TH, Austin CP, Liu S. Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death. Bioorganic & Medicinal Chemistry. 17: 5139-45. PMID 19540764 DOI: 10.1016/J.Bmc.2009.05.054 |
0.388 |
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| 2009 |
MacArthur R, Leister W, Veith H, Shinn P, Southall N, Austin CP, Inglese J, Auld DS. Monitoring compound integrity with cytochrome P450 assays and qHTS. Journal of Biomolecular Screening. 14: 538-46. PMID 19483146 DOI: 10.1177/1087057109336954 |
0.328 |
|
| 2009 |
Motabar O, Shi ZD, Goldin E, Liu K, Southall N, Sidransky E, Austin CP, Griffiths GL, Zheng W. A new resorufin-based alpha-glucosidase assay for high-throughput screening. Analytical Biochemistry. 390: 79-84. PMID 19371716 DOI: 10.1016/J.Ab.2009.04.010 |
0.309 |
|
| 2009 |
Auld DS, Zhang YQ, Southall NT, Rai G, Landsman M, MacLure J, Langevin D, Thomas CJ, Austin CP, Inglese J. A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution. Journal of Medicinal Chemistry. 52: 1450-8. PMID 19215089 DOI: 10.1021/Jm8014525 |
0.331 |
|
| 2009 |
Yi F, Zhu P, Southall N, Inglese J, Austin CP, Zheng W, Regan L. An AlphaScreen-based high-throughput screen to identify inhibitors of Hsp90-cochaperone interaction. Journal of Biomolecular Screening. 14: 273-81. PMID 19211782 DOI: 10.1177/1087057108330114 |
0.395 |
|
| 2009 |
Xia M, Huang R, Guo V, Southall N, Cho MH, Inglese J, Austin CP, Nirenberg M. Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memory. Proceedings of the National Academy of Sciences of the United States of America. 106: 2412-7. PMID 19196967 DOI: 10.1073/Pnas.0813020106 |
0.379 |
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| 2009 |
Zheng W, Motabar O, Liu K, Goldin E, Southall N, Marugan J, Austin C, Sidransky E. 155. High Throughput screen for identifying small molecule modulators of alpha-glucosidase for the potential treatment of Pompe disease Molecular Genetics and Metabolism. 96: S46. DOI: 10.1016/J.Ymgme.2008.11.156 |
0.321 |
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| 2008 |
Liu K, Titus S, Southall N, Zhu P, Inglese J, Austin CP, Zheng W. Comparison on functional assays for Gq-coupled GPCRs by measuring inositol monophospate-1 and intracellular calcium in 1536-well plate format. Current Chemical Genomics. 1: 70-8. PMID 20161830 DOI: 10.2174/1875397300801010070 |
0.376 |
|
| 2008 |
Titus SA, Li X, Southall N, Lu J, Inglese J, Brasch M, Austin CP, Zheng W. A cell-based PDE4 assay in 1536-well plate format for high-throughput screening. Journal of Biomolecular Screening. 13: 609-18. PMID 18591513 DOI: 10.1177/1087057108319977 |
0.374 |
|
| 2008 |
Auld DS, Southall NT, Jadhav A, Johnson RL, Diller DJ, Simeonov A, Austin CP, Inglese J. Characterization of chemical libraries for luciferase inhibitory activity. Journal of Medicinal Chemistry. 51: 2372-86. PMID 18363348 DOI: 10.1021/Jm701302V |
0.338 |
|
| 2008 |
Xia M, Huang R, Witt KL, Southall N, Fostel J, Cho MH, Jadhav A, Smith CS, Inglese J, Portier CJ, Tice RR, Austin CP. Compound cytotoxicity profiling using quantitative high-throughput screening. Environmental Health Perspectives. 116: 284-91. PMID 18335092 DOI: 10.1289/Ehp.10727 |
0.307 |
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| 2008 |
Huang R, Southall N, Cho MH, Xia M, Inglese J, Austin CP. Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening. Chemical Research in Toxicology. 21: 659-67. PMID 18281954 DOI: 10.1021/Tx700365E |
0.344 |
|
| 2008 |
Skoumbourdis AP, Huang R, Southall N, Leister W, Guo V, Cho MH, Inglese J, Nirenberg M, Austin CP, Xia M, Thomas CJ. Identification of a potent new chemotype for the selective inhibition of PDE4. Bioorganic & Medicinal Chemistry Letters. 18: 1297-303. PMID 18243697 DOI: 10.1016/J.Bmcl.2008.01.028 |
0.309 |
|
| 2008 |
Titus S, Neumann S, Zheng W, Southall N, Michael S, Klumpp C, Yasgar A, Shinn P, Thomas CJ, Inglese J, Gershengorn MC, Austin CP. Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor. Journal of Biomolecular Screening. 13: 120-7. PMID 18216391 DOI: 10.1177/1087057107313786 |
0.378 |
|
| 2008 |
Xie Y, Deng S, Thomas CJ, Liu Y, Zhang YQ, Rinderspacher A, Huang W, Gong G, Wyler M, Cayanis E, Aulner N, Többen U, Chung C, Pampou S, Southall N, et al. Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation. Bioorganic & Medicinal Chemistry Letters. 18: 329-35. PMID 18024113 DOI: 10.1016/J.Bmcl.2007.10.100 |
0.386 |
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| 2007 |
Davis RE, Zhang YQ, Southall N, Staudt LM, Austin CP, Inglese J, Auld DS. A cell-based assay for IkappaBalpha stabilization using a two-color dual luciferase-based sensor. Assay and Drug Development Technologies. 5: 85-103. PMID 17355202 DOI: 10.1089/Adt.2006.048 |
0.358 |
|
| 2002 |
Southall NT, Dill KA. Potential of mean force between two hydrophobic solutes in water. Biophysical Chemistry. 101: 295-307. PMID 12488009 DOI: 10.1016/S0301-4622(02)00167-9 |
0.372 |
|
| 2002 |
Hribar B, Southall NT, Vlachy V, Dill KA. How ions affect the structure of water. Journal of the American Chemical Society. 124: 12302-11. PMID 12371874 DOI: 10.1021/Ja026014H |
0.447 |
|
| 2002 |
Urbi T, Vlachy V, Kalyuzhnyi YV, Southall NT, Dill KA. A two-dimensional model of water: Solvation of nonpolar solutes Journal of Chemical Physics. 116: 723-729. DOI: 10.1063/1.1427307 |
0.378 |
|
| 2002 |
Southall NT, Dill KA, Haymet ADJ. A view of the hydrophobic effect Journal of Physical Chemistry B. 106: 521-533. DOI: 10.1021/Jp015514E |
0.467 |
|
| 2001 |
Southall NT, Dill KA. Response to “Comment on ‘The Mechanism of Hydrophobic Solvation Depends on Solute Radius',J.Phys. Chem. B2000,104, 1326” The Journal of Physical Chemistry B. 105: 2082-2083. DOI: 10.1021/Jp010003D |
0.361 |
|
| 2000 |
Urbič T, Vlachy V, Kalyuzhnyi YV, Southall NT, Dill KA. A two-dimensional model of water: Theory and computer simulations Journal of Chemical Physics. 112: 2843-2848. DOI: 10.1063/1.480928 |
0.384 |
|
| 2000 |
Southall NT, Dill KA. The mechanism of hydrophobic solvation depends on solute radius Journal of Physical Chemistry B. 104: 1326-1331. DOI: 10.1021/Jp992860B |
0.38 |
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