| Year |
Citation |
Score |
| 2020 |
Wozniak JM, Silva TA, Thomas D, Siqueira-Neto JL, McKerrow JH, Gonzalez DJ, Calvet CM. Molecular dissection of chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways. Plos Neglected Tropical Diseases. 14: e0007980. PMID 32433643 DOI: 10.1371/Journal.Pntd.0007980 |
0.377 |
|
| 2020 |
Singh B, Bernatchez JA, McCall LI, Calvet CM, Ackermann J, Souza JM, Thomas D, Silva EM, Bachovchin KA, Klug DM, Jalani HB, Bag S, Buskes MJ, Leed SE, Roncal NE, ... ... McKerrow J, et al. Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors. Acs Medicinal Chemistry Letters. 11: 249-257. PMID 32184953 DOI: 10.1021/Acsmedchemlett.9B00453 |
0.387 |
|
| 2020 |
Chenna BC, Li L, Mellott D, Zhai X, Siqueira-Neto JL, Calvet Alvarez C, Bernatchez J, Desormeaux E, Alvarez Hernandez E, Gomez J, McKerrow J, Cruz-Reyes J, Meek TD. Peptidomimetic Vinyl Heterocycle Inhibitors of Cruzain Effect Anti-Trypanosomal Activity. Journal of Medicinal Chemistry. PMID 32125159 DOI: 10.1021/Acs.Jmedchem.9B02078 |
0.421 |
|
| 2020 |
Shing B, Singh S, Podust LM, McKerrow JH, Debnath A. The antifungal drug isavuconazole is both amebicidal and cysticidal against . Antimicrobial Agents and Chemotherapy. PMID 32094126 DOI: 10.1128/Aac.02223-19 |
0.34 |
|
| 2020 |
Chenna BC, Li L, Mellott DM, Zhai X, Siqueira-Neto JL, Alvarez CC, Bernatchez JA, Desormeaux E, Hernandez EA, Gomez J, McKerrow JH, Cruz-Reyes J, Meek TD. PeptidomimeticVinyl Heterocyclic Inhibitors of CruzainEffect Antitrypanosomal Activity Journal of Medicinal Chemistry. DOI: 10.1021/Acs.Jmedchem.9B02078.S001 |
0.407 |
|
| 2019 |
Shi D, Chahal KK, Oto P, Nothias LF, Debnath A, McKerrow JH, Podust LM, Abagyan R. Identification of four amoebicidal non-toxic compounds by a molecular docking screen of Naegleria fowleri sterol Δ8-Δ7-isomerase and phenotypic assays. Acs Infectious Diseases. PMID 31583882 DOI: 10.1021/Acsinfecdis.9B00227 |
0.333 |
|
| 2018 |
Rebello KM, McKerrow JH, Mota EM, O Donoghue AJ, Neves-Ferreira AGC. Activity profiling of peptidases in Angiostrongylus costaricensis first-stage larvae and adult worms. Plos Neglected Tropical Diseases. 12: e0006923. PMID 30379807 DOI: 10.1371/Journal.Pntd.0006923 |
0.391 |
|
| 2018 |
White Bear J, Long T, Skinner D, McKerrow JH. Predictions of novel Schistosoma mansoni - human protein interactions consistent with experimental data. Scientific Reports. 8: 13092. PMID 30166569 DOI: 10.1038/S41598-018-31272-1 |
0.353 |
|
| 2018 |
McKerrow JH. The diverse roles of cysteine proteases in parasites and their suitability as drug targets. Plos Neglected Tropical Diseases. 12: e0005639. PMID 30138311 DOI: 10.1371/Journal.Pntd.0005639 |
0.393 |
|
| 2018 |
McKerrow JH. Update on drug development targeting parasite cysteine proteases. Plos Neglected Tropical Diseases. 12: e0005850. PMID 30138309 DOI: 10.1371/Journal.Pntd.0005850 |
0.39 |
|
| 2018 |
Corvo I, Ferraro F, Merlino A, Zuberbühler K, O'Donoghue AJ, Pastro L, Pi-Denis N, Basika T, Roche L, McKerrow JH, Craik CS, Caffrey CR, Tort JF. Substrate Specificity of Cysteine Proteases Beyond the S Pocket: Mutagenesis and Molecular Dynamics Investigation of Cathepsins L. Frontiers in Molecular Biosciences. 5: 40. PMID 29725596 DOI: 10.3389/Fmolb.2018.00040 |
0.345 |
|
| 2018 |
Chaparro JD, Cheng T, Tran UP, Andrade RM, Brenner SBT, Hwang G, Cohn S, Hirata K, McKerrow JH, Reed SL. Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in in vitro and in vivo models of toxoplasmosis. Plos One. 13: e0193982. PMID 29565998 DOI: 10.1371/Journal.Pone.0193982 |
0.376 |
|
| 2018 |
Debnath A, Nelson AT, Silva-Olivares A, Shibayama M, Siegel D, McKerrow JH.
Efficacy of Ebselen and BAY 11-7082 Against. Frontiers in Microbiology. 9: 414. PMID 29559968 DOI: 10.3389/Fmicb.2018.00414 |
0.317 |
|
| 2018 |
Zyserman I, Mondal D, Sarabia F, McKerrow JH, Roush WR, Debnath A. Identification of cysteine protease inhibitors as new drug leads against Naegleria fowleri. Experimental Parasitology. PMID 29551628 DOI: 10.1016/J.Exppara.2018.03.010 |
0.373 |
|
| 2017 |
Debnath A, Calvet CM, Jennings G, Zhou W, Aksenov A, Luth MR, Abagyan R, Nes WD, McKerrow JH, Podust LM. CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM). Plos Neglected Tropical Diseases. 11: e0006104. PMID 29284029 DOI: 10.1371/Journal.Pntd.0006104 |
0.366 |
|
| 2017 |
Calvet CM, Choi JY, Thomas D, Suzuki B, Hirata K, Lostracco-Johnson S, de Mesquita LB, Nogueira A, Meuser-Batista M, Silva TA, Siqueira-Neto JL, Roush WR, de Souza Pereira MC, McKerrow JH, Podust LM. 4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection. Plos Neglected Tropical Diseases. 11: e0006132. PMID 29281643 DOI: 10.1371/Journal.Pntd.0006132 |
0.394 |
|
| 2017 |
McCall LI, Morton JT, Bernatchez JA, Siqueira-Neto JL, Knight R, Dorrestein PC, McKerrow JH. Mass Spectrometry-Based Chemical Cartography of a Cardiac Parasitic Infection. Analytical Chemistry. PMID 28892370 DOI: 10.1021/Acs.Analchem.7B02423 |
0.328 |
|
| 2017 |
Long T, Rojo-Arreola L, Shi D, El-Sakkary N, Jarnagin K, Rock F, Meewan M, Rascón AA, Lin L, Cunningham KA, Lemieux GA, Podust L, Abagyan R, Ashrafi K, McKerrow JH, et al. Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target. Plos Neglected Tropical Diseases. 11: e0005680. PMID 28704396 DOI: 10.1371/Journal.Pntd.0005680 |
0.313 |
|
| 2017 |
McKerrow JH, Lipinski CA. The rule of five should not impede anti-parasitic drug development. International Journal For Parasitology. Drugs and Drug Resistance. 7: 248-249. PMID 28623818 DOI: 10.1016/J.Ijpddr.2017.05.003 |
0.305 |
|
| 2017 |
Debnath A, McKerrow JH. Editorial: Drug Development for Parasite-Induced Diarrheal Diseases. Frontiers in Microbiology. 8: 577. PMID 28421063 DOI: 10.3389/Fmicb.2017.00577 |
0.329 |
|
| 2016 |
De Muylder G, Vanhollebeke B, Caljon G, Wolfe AR, McKerrow J, Dujardin JC. Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions. Plos Neglected Tropical Diseases. 10: e0005234. PMID 28036391 DOI: 10.1371/Journal.Pntd.0005234 |
0.431 |
|
| 2016 |
Ottilie S, Goldgof GM, Calvet CM, Jennings GK, LaMonte G, Schenken J, Vigil E, Kumar P, McCall LI, Lopes ES, Gunawan F, Yang J, Suzuki Y, Siqueira-Neto JL, McKerrow JH, et al. Rapid Chagas disease drug target discovery using directed evolution in drug-sensitive yeast. Acs Chemical Biology. PMID 27977118 DOI: 10.1021/Acschembio.6B01037 |
0.386 |
|
| 2016 |
Goupil LS, Ivry SL, Hsieh I, Suzuki BM, Craik CS, O'Donoghue AJ, McKerrow JH. Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria. Plos Neglected Tropical Diseases. 10: e0004893. PMID 27501047 DOI: 10.1371/Journal.Pntd.0004893 |
0.449 |
|
| 2016 |
McCall LI, Siqueira-Neto JL, McKerrow JH. Location, Location, Location: Five Facts about Tissue Tropism and Pathogenesis. Plos Pathogens. 12: e1005519. PMID 27227827 DOI: 10.1371/Journal.Ppat.1005519 |
0.322 |
|
| 2016 |
Parsonage D, Sheng F, Hirata K, Debnath A, McKerrow JH, Reed SL, Abagyan R, Poole LB, Podust LM. X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action. Journal of Structural Biology. PMID 26876147 DOI: 10.1016/J.Jsb.2016.02.015 |
0.332 |
|
| 2016 |
Jones BD, Tochowicz A, Tang Y, Cameron MD, McCall LI, Hirata K, Siqueira-Neto JL, Reed SL, McKerrow JH, Roush WR. Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain. Acs Medicinal Chemistry Letters. 7: 77-82. PMID 26819670 DOI: 10.1021/Acsmedchemlett.5B00336 |
0.374 |
|
| 2016 |
Long T, Neitz RJ, Beasley R, Kalyanaraman C, Suzuki BM, Jacobson MP, Dissous C, McKerrow JH, Drewry DH, Zuercher WJ, Singh R, Caffrey CR. Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni. Plos Neglected Tropical Diseases. 10: e0004356. PMID 26751972 DOI: 10.1371/Journal.Pntd.0004356 |
0.374 |
|
| 2015 |
Schulze CJ, Donia MS, Siqueira-Neto JL, Ray D, Raskatov JA, Green RE, McKerrow JH, Fischbach MA, Linington RG. Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei. Acs Chemical Biology. PMID 26270237 DOI: 10.1021/Acschembio.5B00308 |
0.356 |
|
| 2015 |
Khare S, Roach SL, Barnes SW, Hoepfner D, Walker JR, Chatterjee AK, Neitz RJ, Arkin MR, McNamara CW, Ballard J, Lai Y, Fu Y, Molteni V, Yeh V, McKerrow JH, et al. Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease. Plos Pathogens. 11: e1005058. PMID 26186534 DOI: 10.1371/Journal.Ppat.1005058 |
0.39 |
|
| 2015 |
Avelar LA, Camilo CD, de Albuquerque S, Fernandes WB, Gonçalez C, Kenny PW, Leitão A, McKerrow JH, Montanari CA, Orozco EV, Ribeiro JF, Rocha JR, Rosini F, Saidel ME. Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors. Plos Neglected Tropical Diseases. 9: e0003916. PMID 26173110 DOI: 10.1371/Journal.Pntd.0003916 |
0.337 |
|
| 2015 |
Ekins S, Lage de Siqueira-Neto J, McCall LI, Sarker M, Yadav M, Ponder EL, Kallel EA, Kellar D, Chen S, Arkin M, Bunin BA, McKerrow JH, Talcott C. Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery. Plos Neglected Tropical Diseases. 9: e0003878. PMID 26114876 DOI: 10.1371/Journal.Pntd.0003878 |
0.336 |
|
| 2015 |
Fajtová P, Štefanić S, Hradilek M, Dvořák J, Vondrášek J, Jílková A, Ulrychová L, McKerrow JH, Caffrey CR, Mareš M, Horn M. Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors. Plos Neglected Tropical Diseases. 9: e0003827. PMID 26039195 DOI: 10.1371/Journal.Pntd.0003827 |
0.479 |
|
| 2015 |
Shahinas D, Debnath A, Benedict C, McKerrow JH, Pillai DR. Heat shock protein 90 inhibitors repurposed against Entamoeba histolytica. Frontiers in Microbiology. 6: 368. PMID 26029171 DOI: 10.3389/Fmicb.2015.00368 |
0.327 |
|
| 2015 |
McCall LI, El Aroussi A, Choi JY, Vieira DF, De Muylder G, Johnston JB, Chen S, Kellar D, Siqueira-Neto JL, Roush WR, Podust LM, McKerrow JH. Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase. Plos Neglected Tropical Diseases. 9: e0003588. PMID 25768284 DOI: 10.1371/Journal.Pntd.0003588 |
0.44 |
|
| 2015 |
Fonseca NC, da Cruz LF, da Silva Villela F, do Nascimento Pereira GA, de Siqueira-Neto JL, Kellar D, Suzuki BM, Ray D, de Souza TB, Alves RJ, Sales Júnior PA, Romanha AJ, Murta SM, McKerrow JH, Caffrey CR, et al. Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1. Antimicrobial Agents and Chemotherapy. 59: 2666-77. PMID 25712353 DOI: 10.1128/Aac.04601-14 |
0.367 |
|
| 2015 |
Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rascón AA, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, ... ... McKerrow JH, et al. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. Plos Neglected Tropical Diseases. 9: e0003534. PMID 25700363 DOI: 10.1371/Journal.Pntd.0003534 |
0.329 |
|
| 2015 |
Zhou Y, Vedantham P, Lu K, Agudelo J, Carrion R, Nunneley JW, Barnard D, Pöhlmann S, McKerrow JH, Renslo AR, Simmons G. Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Research. 116: 76-84. PMID 25666761 DOI: 10.1016/J.Antiviral.2015.01.011 |
0.399 |
|
| 2015 |
Neitz RJ, Chen S, Supek F, Yeh V, Kellar D, Gut J, Bryant C, Gallardo-Godoy A, Molteni V, Roach SL, Khare S, Stinson M, Chatterjee AK, Robertson S, Renslo AR, ... ... McKerrow J, et al. Lead identification to clinical candidate selection: drugs for Chagas disease. Journal of Biomolecular Screening. 20: 101-11. PMID 25281737 DOI: 10.1177/1087057114553103 |
0.336 |
|
| 2014 |
Jílková A, Horn M, Rezáčová P, Marešová L, Fajtová P, Brynda J, Vondrášek J, McKerrow JH, Caffrey CR, Mareš M. Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch. Structure (London, England : 1993). 22: 1786-98. PMID 25456815 DOI: 10.1016/J.Str.2014.09.015 |
0.37 |
|
| 2014 |
Vieira DF, Choi JY, Calvet CM, Siqueira-Neto JL, Johnston JB, Kellar D, Gut J, Cameron MD, McKerrow JH, Roush WR, Podust LM. Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51. Journal of Medicinal Chemistry. 57: 10162-75. PMID 25393646 DOI: 10.1021/Jm501568B |
0.342 |
|
| 2014 |
Calvet CM, Vieira DF, Choi JY, Kellar D, Cameron MD, Siqueira-Neto JL, Gut J, Johnston JB, Lin L, Khan S, McKerrow JH, Roush WR, Podust LM. 4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency. Journal of Medicinal Chemistry. 57: 6989-7005. PMID 25101801 DOI: 10.1021/Jm500448U |
0.409 |
|
| 2014 |
McCall LI, McKerrow JH. Determinants of disease phenotype in trypanosomatid parasites. Trends in Parasitology. 30: 342-9. PMID 24946952 DOI: 10.1016/J.Pt.2014.05.001 |
0.326 |
|
| 2014 |
Choi JY, Calvet CM, Vieira DF, Gunatilleke SS, Cameron MD, McKerrow JH, Podust LM, Roush WR. R-Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi. Acs Medicinal Chemistry Letters. 5: 434-9. PMID 24900854 DOI: 10.1021/Ml500010M |
0.364 |
|
| 2014 |
Dandapani S, Germain AR, Jewett I, le Quement S, Marie JC, Muncipinto G, Duvall JR, Carmody LC, Perez JR, Engel JC, Gut J, Kellar D, Siqueira-Neto JL, McKerrow JH, Kaiser M, et al. Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease. Acs Medicinal Chemistry Letters. 5: 149-53. PMID 24900788 DOI: 10.1021/Ml400403U |
0.346 |
|
| 2014 |
Debnath A, Shahinas D, Bryant C, Hirata K, Miyamoto Y, Hwang G, Gut J, Renslo AR, Pillai DR, Eckmann L, Reed SL, McKerrow JH. Hsp90 inhibitors as new leads to target parasitic diarrheal diseases. Antimicrobial Agents and Chemotherapy. 58: 4138-44. PMID 24820073 DOI: 10.1128/Aac.02576-14 |
0.373 |
|
| 2014 |
Horn M, Fajtová P, Rojo Arreola L, Ulrychová L, Bartošová-Sojková P, Franta Z, Protasio AV, Opavský D, Vondrášek J, McKerrow JH, Mareš M, Caffrey CR, Dvořák J. Trypsin- and Chymotrypsin-like serine proteases in schistosoma mansoni-- 'the undiscovered country'. Plos Neglected Tropical Diseases. 8: e2766. PMID 24676141 DOI: 10.1371/Journal.Pntd.0002766 |
0.419 |
|
| 2014 |
Debnath A, Tunac JB, Silva-Olivares A, Galindo-Gómez S, Shibayama M, McKerrow JH. In vitro efficacy of corifungin against Acanthamoeba castellanii trophozoites and cysts. Antimicrobial Agents and Chemotherapy. 58: 1523-8. PMID 24366747 DOI: 10.1128/Aac.02254-13 |
0.305 |
|
| 2013 |
Abdulla MH, Bakhiet M, Lejon V, Andersson J, McKerrow J, Al-Obeed O, Harris RA. TLTF in cerebrospinal fluid for detection and staging of T. b. gambiense infection. Plos One. 8: e79281. PMID 24260185 DOI: 10.1371/Journal.Pone.0079281 |
0.305 |
|
| 2013 |
Choi JY, Calvet CM, Gunatilleke SS, Ruiz C, Cameron MD, McKerrow JH, Podust LM, Roush WR. Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents. Journal of Medicinal Chemistry. 56: 7651-68. PMID 24079662 DOI: 10.1021/Jm401067S |
0.341 |
|
| 2013 |
Ndao M, Nath-Chowdhury M, Sajid M, Marcus V, Mashiyama ST, Sakanari J, Chow E, Mackey Z, Land KM, Jacobson MP, Kalyanaraman C, McKerrow JH, Arrowood MJ, Caffrey CR. A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection. Antimicrobial Agents and Chemotherapy. 57: 6063-73. PMID 24060869 DOI: 10.1128/Aac.00734-13 |
0.37 |
|
| 2013 |
Wiggers HJ, Rocha JR, Fernandes WB, Sesti-Costa R, Carneiro ZA, Cheleski J, da Silva AB, Juliano L, Cezari MH, Silva JS, McKerrow JH, Montanari CA. Non-peptidic cruzain inhibitors with trypanocidal activity discovered by virtual screening and in vitro assay. Plos Neglected Tropical Diseases. 7: e2370. PMID 23991231 DOI: 10.1371/Journal.Pntd.0002370 |
0.389 |
|
| 2013 |
Corvo I, O'Donoghue AJ, Pastro L, Pi-Denis N, Eroy-Reveles A, Roche L, McKerrow JH, Dalton JP, Craik CS, Caffrey CR, Tort JF. Dissecting the Active Site of the Collagenolytic Cathepsin L3 Protease of the Invasive Stage of Fasciola hepatica Plos Neglected Tropical Diseases. 7. PMID 23875031 DOI: 10.1371/Journal.Pntd.0002269 |
0.39 |
|
| 2013 |
Nishino M, Choy JW, Gushwa NN, Oses-Prieto JA, Koupparis K, Burlingame AL, Renslo AR, McKerrow JH, Taunton J. Hypothemicin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei Elife. 2013. PMID 23853713 DOI: 10.7554/Elife.00712 |
0.773 |
|
| 2013 |
Rascón AA, McKerrow JH. Synthetic and natural protease inhibitors provide insights into parasite development, virulence and pathogenesis Current Medicinal Chemistry. 20: 3078-3102. PMID 23514418 DOI: 10.2174/0929867311320250005 |
0.334 |
|
| 2013 |
Sanchez LM, Knudsen GM, Helbig C, De Muylder G, Mascuch SM, Mackey ZB, Gerwick L, Clayton C, McKerrow JH, Linington RG. Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei. Journal of Natural Products. 76: 630-41. PMID 23445522 DOI: 10.1021/Np300834Q |
0.426 |
|
| 2013 |
Tejman-Yarden N, Miyamoto Y, Leitsch D, Santini J, Debnath A, Gut J, McKerrow JH, Reed SL, Eckmann L. A reprofiled drug, auranofin, is effective against metronidazole-resistant Giardia lamblia. Antimicrobial Agents and Chemotherapy. 57: 2029-35. PMID 23403423 DOI: 10.1128/Aac.01675-12 |
0.352 |
|
| 2013 |
Nishino M, Choy JW, Gushwa NN, Oses-Prieto JA, Koupparis K, Burlingame AL, Renslo AR, McKerrow JH, Taunton J. Correction: Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei Elife. 2. DOI: 10.7554/Elife.01214 |
0.765 |
|
| 2013 |
Nishino M, Choy JW, Gushwa NN, Oses-Prieto JA, Koupparis K, Burlingame AL, Renslo AR, McKerrow JH, Taunton J. Author response: Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei Elife. DOI: 10.7554/Elife.00712.010 |
0.76 |
|
| 2012 |
Mashiyama ST, Koupparis K, Caffrey CR, McKerrow JH, Babbitt PC. A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets. Plos Neglected Tropical Diseases. 6: e1942. PMID 23236535 DOI: 10.1371/Journal.Pntd.0001942 |
0.789 |
|
| 2012 |
Lee GM, Balouch E, Goetz DH, Lazic A, McKerrow JH, Craik CS. Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy. Biochemistry. 51: 10087-98. PMID 23181936 DOI: 10.1021/Bi301305K |
0.325 |
|
| 2012 |
O'Donoghue AJ, Eroy-Reveles AA, Knudsen GM, Ingram J, Zhou M, Statnekov JB, Greninger AL, Hostetter DR, Qu G, Maltby DA, Anderson MO, Derisi JL, McKerrow JH, Burlingame AL, Craik CS. Global identification of peptidase specificity by multiplex substrate profiling. Nature Methods. 9: 1095-100. PMID 23023596 DOI: 10.1038/Nmeth.2182 |
0.595 |
|
| 2012 |
dos Santos Filho JM, Moreira DR, de Simone CA, Ferreira RS, McKerrow JH, Meira CS, Guimarães ET, Soares MB. Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice. Bioorganic & Medicinal Chemistry. 20: 6423-33. PMID 23006639 DOI: 10.1016/J.Bmc.2012.08.047 |
0.324 |
|
| 2012 |
Lavrado J, Mackey Z, Hansell E, McKerrow JH, Paulo A, Moreira R. Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives. Bioorganic & Medicinal Chemistry Letters. 22: 6256-60. PMID 22926067 DOI: 10.1016/J.Bmcl.2012.07.104 |
0.33 |
|
| 2012 |
Debnath A, Tunac JB, Galindo-Gómez S, Silva-Olivares A, Shibayama M, McKerrow JH. Corifungin, a new drug lead against Naegleria, identified from a high-throughput screen. Antimicrobial Agents and Chemotherapy. 56: 5450-7. PMID 22869574 DOI: 10.1128/Aac.00643-12 |
0.341 |
|
| 2012 |
Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, GarcÃa-Rivera G, Orozco E, MartÃnez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, et al. A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nature Medicine. 18: 956-60. PMID 22610278 DOI: 10.1038/Nm.2758 |
0.355 |
|
| 2012 |
Sojka D, Franta Z, Frantová H, Bartosová P, Horn M, Váchová J, O'Donoghue AJ, Eroy-Reveles AA, Craik CS, Knudsen GM, Caffrey CR, McKerrow JH, Mares M, Kopácek P. Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1). The Journal of Biological Chemistry. 287: 21152-63. PMID 22539347 DOI: 10.1074/Jbc.M112.347922 |
0.353 |
|
| 2012 |
Ingram JR, Rafi SB, Eroy-Reveles AA, Ray M, Lambeth L, Hsieh I, Ruelas D, Lim KC, Sakanari J, Craik CS, Jacobson MP, McKerrow JH. Investigation of the proteolytic functions of an expanded cercarial elastase gene family in Schistosoma mansoni. Plos Neglected Tropical Diseases. 6: e1589. PMID 22509414 DOI: 10.1371/Journal.Pntd.0001589 |
0.618 |
|
| 2012 |
Marcellino C, Gut J, Lim KC, Singh R, McKerrow J, Sakanari J. WormAssay: a novel computer application for whole-plate motion-based screening of macroscopic parasites. Plos Neglected Tropical Diseases. 6: e1494. PMID 22303493 DOI: 10.1371/Journal.Pntd.0001494 |
0.334 |
|
| 2012 |
Quezada LA, Sajid M, Lim KC, McKerrow JH. A blood fluke serine protease inhibitor regulates an endogenous larval elastase. The Journal of Biological Chemistry. 287: 7074-83. PMID 22174417 DOI: 10.1074/Jbc.M111.313304 |
0.428 |
|
| 2012 |
Khalaf NB, Muylder GD, Louzir H, McKerrow J, Chenik M. Leishmania major protein disulfide isomerase as a drug target: enzymatic and functional characterization. Parasitology Research. 110: 1911-1917. PMID 22160278 DOI: 10.1007/S00436-011-2717-5 |
0.431 |
|
| 2011 |
Johnson TA, Sohn J, Inman WD, Estee SA, Loveridge ST, Vervoort HC, Tenney K, Liu J, Ang KK, Ratnam J, Bray WM, Gassner NC, Shen YY, Lokey RS, McKerrow JH, et al. Natural product libraries to accelerate the high-throughput discovery of therapeutic leads. Journal of Natural Products. 74: 2545-55. PMID 22129061 DOI: 10.1021/Np200673B |
0.322 |
|
| 2011 |
Abdulla MH, Lim KC, McKerrow JH, Caffrey CR. Proteomic identification of IPSE/alpha-1 as a major hepatotoxin secreted by Schistosoma mansoni eggs. Plos Neglected Tropical Diseases. 5: e1368. PMID 22039561 DOI: 10.1371/Journal.Pntd.0001368 |
0.307 |
|
| 2011 |
Ingram J, Knudsen G, Lim KC, Hansell E, Sakanari J, McKerrow J. Proteomic analysis of human skin treated with larval schistosome peptidases reveals distinct invasion strategies among species of blood flukes. Plos Neglected Tropical Diseases. 5: e1337. PMID 21980548 DOI: 10.1371/Journal.Pntd.0001337 |
0.566 |
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| 2011 |
Doyle PS, Zhou YM, Hsieh I, Greenbaum DC, McKerrow JH, Engel JC. The Trypanosoma cruzi protease cruzain mediates immune evasion. Plos Pathogens. 7: e1002139. PMID 21909255 DOI: 10.1371/Journal.Ppat.1002139 |
0.372 |
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| 2011 |
Jílková A, Rezácová P, Lepsík M, Horn M, Váchová J, Fanfrlík J, Brynda J, McKerrow JH, Caffrey CR, Mares M. Structural basis for inhibition of cathepsin B drug target from the human blood fluke, Schistosoma mansoni. The Journal of Biological Chemistry. 286: 35770-81. PMID 21832058 DOI: 10.1074/Jbc.M111.271304 |
0.437 |
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| 2011 |
Zhou Y, Agudelo J, Lu K, Goetz DH, Hansell E, Chen YT, Roush WR, McKerrow J, Craik CS, Amberg SM, Simmons G. Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. Antiviral Research. 92: 187-94. PMID 21820471 DOI: 10.1016/J.Antiviral.2011.07.016 |
0.342 |
|
| 2011 |
Franta Z, Sojka D, Frantova H, Dvorak J, Horn M, Srba J, Talacko P, Mares M, Schneider E, Craik CS, McKerrow JH, Caffrey CR, Kopacek P. IrCL1 - the haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus. International Journal For Parasitology. 41: 1253-62. PMID 21819989 DOI: 10.1016/J.Ijpara.2011.06.006 |
0.367 |
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| 2011 |
De Muylder G, Ang KK, Chen S, Arkin MR, Engel JC, McKerrow JH. A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit. Plos Neglected Tropical Diseases. 5: e1253. PMID 21811648 DOI: 10.1371/Journal.Pntd.0001253 |
0.353 |
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| 2011 |
Quezada LA, McKerrow JH. Schistosome serine protease inhibitors: parasite defense or homeostasis? Anais Da Academia Brasileira De CiêNcias. 83: 663-72. PMID 21670886 DOI: 10.1590/S0001-37652011000200025 |
0.449 |
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| 2011 |
Mackey ZB, Koupparis K, Nishino M, McKerrow JH. High-throughput analysis of an RNAi library identifies novel kinase targets in Trypanosoma brucei. Chemical Biology & Drug Design. 78: 454-63. PMID 21668652 DOI: 10.1111/J.1747-0285.2011.01156.X |
0.784 |
|
| 2011 |
Sajid M, Robertson SA, Brinen LS, McKerrow JH. Cruzain : the path from target validation to the clinic. Advances in Experimental Medicine and Biology. 712: 100-15. PMID 21660661 DOI: 10.1007/978-1-4419-8414-2_7 |
0.375 |
|
| 2011 |
Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. Mining a cathepsin inhibitor library for new antiparasitic drug leads. Plos Neglected Tropical Diseases. 5: e1023. PMID 21572521 DOI: 10.1371/Journal.Pntd.0001023 |
0.462 |
|
| 2011 |
Ben Khalaf N, De Muylder G, Ratnam J, Kean-Hooi Ang K, Arkin M, McKerrow J, Chenik M. A high-throughput turbidometric assay for screening inhibitors of Leishmania major protein disulfide isomerase. Journal of Biomolecular Screening. 16: 545-51. PMID 21441416 DOI: 10.1177/1087057111401026 |
0.378 |
|
| 2011 |
Gut J, Ang KK, Legac J, Arkin MR, Rosenthal PJ, McKerrow JH. An image-based assay for high throughput screening of Giardia lamblia. Journal of Microbiological Methods. 84: 398-405. PMID 21262276 DOI: 10.1016/J.Mimet.2010.12.026 |
0.34 |
|
| 2011 |
Swenerton RK, Zhang S, Sajid M, Medzihradszky KF, Craik CS, Kelly BL, McKerrow JH. The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion. The Journal of Biological Chemistry. 286: 429-40. PMID 20961853 DOI: 10.1074/Jbc.M110.138313 |
0.817 |
|
| 2010 |
Ding D, Zhao Y, Meng Q, Xie D, Nare B, Chen D, Bacchi CJ, Yarlett N, Zhang YK, Hernandez V, Xia Y, Freund Y, Abdulla M, Ang KH, Ratnam J, ... McKerrow JH, et al. Discovery of novel benzoxaborole-based potent antitrypanosomal agents. Acs Medicinal Chemistry Letters. 1: 165-9. PMID 24900190 DOI: 10.1021/Ml100013S |
0.307 |
|
| 2010 |
Stefanić S, Dvořák J, Horn M, Braschi S, Sojka D, Ruelas DS, Suzuki B, Lim KC, Hopkins SD, McKerrow JH, Caffrey CR. RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening. Plos Neglected Tropical Diseases. 4: e850. PMID 20976050 DOI: 10.1371/Journal.Pntd.0000850 |
0.38 |
|
| 2010 |
Hernandes MZ, Rabello MM, Leite AC, Cardoso MV, Moreira DR, Brondani DJ, Simone CA, Reis LC, Souza MA, Pereira VR, Ferreira RS, McKerrow JH. Studies toward the structural optimization of novel thiazolylhydrazone-based potent antitrypanosomal agents. Bioorganic & Medicinal Chemistry. 18: 7826-35. PMID 20961766 DOI: 10.1016/J.Bmc.2010.09.056 |
0.35 |
|
| 2010 |
Chen YT, Brinen LS, Kerr ID, Hansell E, Doyle PS, McKerrow JH, Roush WR. In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. Plos Neglected Tropical Diseases. 4. PMID 20856868 DOI: 10.1371/Journal.Pntd.0000825 |
0.412 |
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| 2010 |
Swenerton RK, Knudsen GM, Sajid M, Kelly BL, McKerrow JH. Leishmania subtilisin is a maturase for the trypanothione reductase system and contributes to disease pathology. The Journal of Biological Chemistry. 285: 31120-9. PMID 20675366 DOI: 10.1074/Jbc.M110.114462 |
0.796 |
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| 2010 |
Engel JC, Ang KK, Chen S, Arkin MR, McKerrow JH, Doyle PS. Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease. Antimicrobial Agents and Chemotherapy. 54: 3326-34. PMID 20547819 DOI: 10.1128/Aac.01777-09 |
0.408 |
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| 2010 |
Chen CK, Leung SS, Guilbert C, Jacobson MP, McKerrow JH, Podust LM. Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole. Plos Neglected Tropical Diseases. 4: e651. PMID 20386598 DOI: 10.1371/Journal.Pntd.0000651 |
0.388 |
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| 2010 |
Doyle PS, Chen CK, Johnston JB, Hopkins SD, Leung SS, Jacobson MP, Engel JC, McKerrow JH, Podust LM. A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection. Antimicrobial Agents and Chemotherapy. 54: 2480-8. PMID 20385875 DOI: 10.1128/Aac.00281-10 |
0.36 |
|
| 2010 |
He C, Nora GP, Schneider EL, Kerr ID, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, Liu WT, Eckmann L, Dorrestein PC, ... ... McKerrow J, et al. A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. The Journal of Biological Chemistry. 285: 18516-27. PMID 20378535 DOI: 10.1074/Jbc.M109.086181 |
0.418 |
|
| 2010 |
Zhang S, Kim CC, Batra S, McKerrow JH, Loke P. Delineation of diverse macrophage activation programs in response to intracellular parasites and cytokines. Plos Neglected Tropical Diseases. 4: e648. PMID 20361029 DOI: 10.1371/Journal.Pntd.0000648 |
0.497 |
|
| 2010 |
Watts KR, Ratnam J, Ang KH, Tenney K, Compton JE, McKerrow J, Crews P. Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi. Bioorganic & Medicinal Chemistry. 18: 2566-74. PMID 20303767 DOI: 10.1016/J.Bmc.2010.02.034 |
0.357 |
|
| 2010 |
Brak K, Kerr ID, Barrett KT, Fuchi N, Debnath M, Ang K, Engel JC, McKerrow JH, Doyle PS, Brinen LS, Ellman JA. Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy. Journal of Medicinal Chemistry. 53: 1763-73. PMID 20088534 DOI: 10.1021/Jm901633V |
0.38 |
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| 2010 |
Dvorák J, Beckmann S, Lim KC, Engel JC, Grevelding CG, McKerrow JH, Caffrey CR. Biolistic transformation of Schistosoma mansoni: Studies with modified reporter-gene constructs containing regulatory regions of protease genes. Molecular and Biochemical Parasitology. 170: 37-40. PMID 19914302 DOI: 10.1016/J.Molbiopara.2009.11.001 |
0.307 |
|
| 2010 |
Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin CP, Thomas CJ, Shoichet BK, et al. Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. Journal of Medicinal Chemistry. 53: 52-60. PMID 19908842 DOI: 10.1021/Jm901069A |
0.425 |
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| 2009 |
Ovat A, Muindi F, Fagan C, Brouner M, Hansell E, Dvorák J, Sojka D, Kopácek P, McKerrow JH, Caffrey CR, Powers JC. Aza-peptidyl Michael acceptor and epoxide inhibitors--potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases). Journal of Medicinal Chemistry. 52: 7192-210. PMID 19848405 DOI: 10.1021/Jm900849H |
0.344 |
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| 2009 |
Bryant C, Kerr ID, Debnath M, Ang KK, Ratnam J, Ferreira RS, Jaishankar P, Zhao D, Arkin MR, McKerrow JH, Brinen LS, Renslo AR. Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorganic & Medicinal Chemistry Letters. 19: 6218-21. PMID 19773167 DOI: 10.1016/J.Bmcl.2009.08.098 |
0.346 |
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| 2009 |
Mallari JP, Shelat AA, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK. Structure-guided development of selective TbcatB inhibitors. Journal of Medicinal Chemistry. 52: 6489-93. PMID 19769357 DOI: 10.1021/Jm900908P |
0.414 |
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| 2009 |
Mckerrow JH, Doyle PS, Engel JC, Podust LM, Robertson SA, Ferreira R, Saxton T, Arkin M, Kerr ID, Brinen LS, Craik CS. Two approaches to discovering and developing new drugs for Chagas disease Memorias Do Instituto Oswaldo Cruz. 104: 263-269. PMID 19753483 DOI: 10.1590/S0074-02762009000900034 |
0.323 |
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| 2009 |
Abodeely M, DuBois KN, Hehl A, Stefanic S, Sajid M, DeSouza W, Attias M, Engel JC, Hsieh I, Fetter RD, McKerrow JH. A contiguous compartment functions as endoplasmic reticulum and endosome/lysosome in Giardia lamblia. Eukaryotic Cell. 8: 1665-76. PMID 19749174 DOI: 10.1128/Ec.00123-09 |
0.751 |
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| 2009 |
Arico-Muendel C, Centrella PA, Contonio BD, Morgan BA, O'Donovan G, Paradise CL, Skinner SR, Sluboski B, Svendsen JL, White KF, Debnath A, Gut J, Wilson N, McKerrow JH, DeRisi JL, et al. Antiparasitic activities of novel, orally available fumagillin analogs. Bioorganic & Medicinal Chemistry Letters. 19: 5128-31. PMID 19648008 DOI: 10.1016/J.Bmcl.2009.07.029 |
0.419 |
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| 2009 |
Ferreira RS, Bryant C, Ang KK, McKerrow JH, Shoichet BK, Renslo AR. Divergent modes of enzyme inhibition in a homologous structure-activity series. Journal of Medicinal Chemistry. 52: 5005-8. PMID 19637873 DOI: 10.1021/Jm9009229 |
0.368 |
|
| 2009 |
Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS. Vinyl sulfones as antiparasitic agents and a structural basis for drug design. The Journal of Biological Chemistry. 284: 25697-703. PMID 19620707 DOI: 10.1074/Jbc.M109.014340 |
0.423 |
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| 2009 |
Abdulla MH, Ruelas DS, Wolff B, Snedecor J, Lim KC, Xu F, Renslo AR, Williams J, McKerrow JH, Caffrey CR. Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening. Plos Neglected Tropical Diseases. 3: e478. PMID 19597541 DOI: 10.1371/Journal.Pntd.0000478 |
0.337 |
|
| 2009 |
Dvorák J, Mashiyama ST, Sajid M, Braschi S, Delcroix M, Schneider EL, McKerrow WH, Bahgat M, Hansell E, Babbitt PC, Craik CS, McKerrow JH, Caffrey CR. SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni. Plos Neglected Tropical Diseases. 3: e449. PMID 19488406 DOI: 10.1371/Journal.Pntd.0000449 |
0.442 |
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| 2009 |
Caffrey CR, Rohwer A, Oellien F, Marhöfer RJ, Braschi S, Oliveira G, McKerrow JH, Selzer PM. A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni. Plos One. 4: e4413. PMID 19198654 DOI: 10.1371/Journal.Pone.0004413 |
0.396 |
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| 2009 |
Chen CK, Doyle PS, Yermalitskaya LV, Mackey ZB, Ang KK, McKerrow JH, Podust LM. Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit. Plos Neglected Tropical Diseases. 3: e372. PMID 19190730 DOI: 10.1371/Journal.Pntd.0000372 |
0.407 |
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| 2008 |
McKerrow JH, Rosenthal PJ, Swenerton R, Doyle P. Development of protease inhibitors for protozoan infections. Current Opinion in Infectious Diseases. 21: 668-72. PMID 18978536 DOI: 10.1097/Qco.0B013E328315Cca9 |
0.801 |
|
| 2008 |
Abdulla MH, O'Brien T, Mackey ZB, Sajid M, Grab DJ, McKerrow JH. RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model. Plos Neglected Tropical Diseases. 2: e298. PMID 18820745 DOI: 10.1371/Journal.Pntd.0000298 |
0.675 |
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| 2008 |
O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey CR, McKerrow JH. A parasite cysteine protease is key to host protein degradation and iron acquisition. The Journal of Biological Chemistry. 283: 28934-43. PMID 18701454 DOI: 10.1074/Jbc.M805824200 |
0.74 |
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| 2008 |
Fricker SP, Mosi RM, Cameron BR, Baird I, Zhu Y, Anastassov V, Cox J, Doyle PS, Hansell E, Lau G, Langille J, Olsen M, Qin L, Skerlj R, Wong RS, ... ... McKerrow JH, et al. Metal compounds for the treatment of parasitic diseases. Journal of Inorganic Biochemistry. 102: 1839-45. PMID 18684510 DOI: 10.1016/J.Jinorgbio.2008.05.010 |
0.341 |
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| 2008 |
Hansell E, Braschi S, Medzihradszky KF, Sajid M, Debnath M, Ingram J, Lim KC, McKerrow JH. Proteomic analysis of skin invasion by blood fluke larvae. Plos Neglected Tropical Diseases. 2: e262. PMID 18629379 DOI: 10.1371/Journal.Pntd.0000262 |
0.572 |
|
| 2008 |
Chen YT, Lira R, Hansell E, McKerrow JH, Roush WR. Synthesis of macrocyclic trypanosomal cysteine protease inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 5860-3. PMID 18585034 DOI: 10.1016/J.Bmcl.2008.06.012 |
0.413 |
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| 2008 |
Kongkerd N, Uparanukraw P, Morakote N, Sajid M, McKerrow JH. Identification and characterization of a cathepsin L-like cysteine protease from Gnathostoma spinigerum. Molecular and Biochemical Parasitology. 160: 129-37. PMID 18554733 DOI: 10.1016/J.Molbiopara.2008.05.001 |
0.356 |
|
| 2008 |
DuBois KN, Abodeely M, Sakanari J, Craik CS, Lee M, McKerrow JH, Sajid M. Identification of the major cysteine protease of Giardia and its role in encystation. The Journal of Biological Chemistry. 283: 18024-31. PMID 18445589 DOI: 10.1074/Jbc.M802133200 |
0.779 |
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| 2008 |
Brak K, Doyle PS, McKerrow JH, Ellman JA. Identification of a new class of nonpeptidic inhibitors of cruzain. Journal of the American Chemical Society. 130: 6404-10. PMID 18435536 DOI: 10.1021/Ja710254M |
0.41 |
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| 2008 |
Mallari JP, Shelat A, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK. Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. Bioorganic & Medicinal Chemistry Letters. 18: 2883-5. PMID 18420405 DOI: 10.1016/J.Bmcl.2008.03.083 |
0.393 |
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| 2008 |
Götz MG, James KE, Hansell E, Dvorák J, Seshaadri A, Sojka D, Kopácek P, McKerrow JH, Caffrey CR, Powers JC. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. Journal of Medicinal Chemistry. 51: 2816-32. PMID 18416543 DOI: 10.1021/Jm701311R |
0.351 |
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| 2008 |
Mallari JP, Shelat AA, Obrien T, Caffrey CR, Kosinski A, Connelly M, Harbut M, Greenbaum D, McKerrow JH, Guy RK. Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB. Journal of Medicinal Chemistry. 51: 545-52. PMID 18173229 DOI: 10.1021/Jm070760L |
0.369 |
|
| 2008 |
Stack CM, Caffrey CR, Donnelly SM, Seshaadri A, Lowther J, Tort JF, Collins PR, Robinson MW, Xu W, McKerrow JH, Craik CS, Geiger SR, Marion R, Brinen LS, Dalton JP. Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica. The Journal of Biological Chemistry. 283: 9896-908. PMID 18160404 DOI: 10.1074/Jbc.M708521200 |
0.404 |
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| 2008 |
Dvorák J, Mashiyama ST, Braschi S, Sajid M, Knudsen GM, Hansell E, Lim KC, Hsieh I, Bahgat M, Mackenzie B, Medzihradszky KF, Babbitt PC, Caffrey CR, McKerrow JH. Differential use of protease families for invasion by schistosome cercariae. Biochimie. 90: 345-58. PMID 17936488 DOI: 10.1016/J.Biochi.2007.08.013 |
0.421 |
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| 2008 |
Aslam A, Quinn P, McIntosh RS, Shi J, Ghumra A, McKerrow JH, Bunting KA, Dunne DW, Doenhoff MJ, Morrison SL, Zhang K, Pleass RJ. Proteases from Schistosoma mansoni cercariae cleave IgE at solvent exposed interdomain regions. Molecular Immunology. 45: 567-74. PMID 17631966 DOI: 10.1016/J.Molimm.2007.05.021 |
0.429 |
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| 2007 |
Davis FP, Barkan DT, Eswar N, McKerrow JH, Sali A. Host pathogen protein interactions predicted by comparative modeling. Protein Science : a Publication of the Protein Society. 16: 2585-96. PMID 17965183 DOI: 10.1110/Ps.073228407 |
0.366 |
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| 2007 |
Kanaji S, Tanaka Y, Sakata Y, Takeshita K, Arima K, Ohta S, Hansell EJ, Caffrey C, Mottram JC, Lowther J, Donnelly S, Stack C, Kadowaki T, Yamamoto K, McKerrow JH, et al. Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases. Febs Letters. 581: 4260-4. PMID 17707374 DOI: 10.1016/J.Febslet.2007.07.072 |
0.399 |
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| 2007 |
Doyle PS, Zhou YM, Engel JC, McKerrow JH. A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection. Antimicrobial Agents and Chemotherapy. 51: 3932-9. PMID 17698625 DOI: 10.1128/Aac.00436-07 |
0.353 |
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| 2007 |
Goetz DH, Choe Y, Hansell E, Chen YT, McDowell M, Jonsson CB, Roush WR, McKerrow J, Craik CS. Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus. Biochemistry. 46: 8744-52. PMID 17605471 DOI: 10.1021/Bi0621415 |
0.367 |
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| 2007 |
Meléndez-López SG, Herdman S, Hirata K, Choi MH, Choe Y, Craik C, Caffrey CR, Hansell E, Chávez-Munguía B, Yen TC, Roush WR, McKerrow J, Eckmann L, Guo J, Stanley SL, et al. Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model Eukaryotic Cell. 6: 1130-1136. PMID 17513563 DOI: 10.1128/Ec.00094-07 |
0.42 |
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| 2007 |
Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH. The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. Structure (London, England : 1993). 15: 535-43. PMID 17502099 DOI: 10.1016/J.Str.2007.03.012 |
0.379 |
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| 2007 |
Jolly ER, Chin CS, Miller S, Bahgat MM, Lim KC, DeRisi J, McKerrow JH. Gene expression patterns during adaptation of a helminth parasite to different environmental niches. Genome Biology. 8: R65. PMID 17456242 DOI: 10.1186/Gb-2007-8-4-R65 |
0.758 |
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| 2007 |
Delcroix M, Medzihradsky K, Caffrey CR, Fetter RD, McKerrow JH. Proteomic analysis of adult S. mansoni gut contents. Molecular and Biochemical Parasitology. 154: 95-7. PMID 17451823 DOI: 10.1016/J.Molbiopara.2007.03.008 |
0.414 |
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| 2007 |
Caffrey CR, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, Doyle PS, Fafarman AT, Zorn JA, Land KM, Beauchene J, Schreiber K, Moll H, Ponte-Sucre A, ... ... McKerrow JH, et al. Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro. Antimicrobial Agents and Chemotherapy. 51: 2164-72. PMID 17371810 DOI: 10.1128/Aac.01418-06 |
0.78 |
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| 2007 |
Debnath A, Tashker JS, Sajid M, McKerrow JH. Transcriptional and secretory responses of Entamoeba histolytica to mucins, epithelial cells and bacteria. International Journal For Parasitology. 37: 897-906. PMID 17362964 DOI: 10.1016/J.Ijpara.2007.01.016 |
0.346 |
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| 2007 |
Sojka D, Hajdusek O, Dvorák J, Sajid M, Franta Z, Schneider EL, Craik CS, Vancová M, Buresová V, Bogyo M, Sexton KB, McKerrow JH, Caffrey CR, Kopácek P. IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus. International Journal For Parasitology. 37: 713-24. PMID 17336985 DOI: 10.1016/J.Ijpara.2006.12.020 |
0.425 |
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| 2007 |
Abdulla MH, Lim KC, Sajid M, McKerrow JH, Caffrey CR. Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor. Plos Medicine. 4: e14. PMID 17214506 DOI: 10.1371/Journal.Pmed.0040014 |
0.316 |
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| 2006 |
McKerrow JH, Caffrey C, Kelly B, Loke P, Sajid M. Proteases in parasitic diseases. Annual Review of Pathology. 1: 497-536. PMID 18039124 DOI: 10.1146/Annurev.Pathol.1.110304.100151 |
0.392 |
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| 2006 |
Renslo AR, McKerrow JH. Drug discovery and development for neglected parasitic diseases Nature Chemical Biology. 2: 701-710. PMID 17108988 DOI: 10.1038/Nchembio837 |
0.313 |
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| 2006 |
Blank RB, Lamb EW, Tocheva AS, Crow ET, Lim KC, McKerrow JH, Davies SJ. The common gamma chain cytokines interleukin (IL)-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells. The Journal of Infectious Diseases. 194: 1609-16. PMID 17083048 DOI: 10.1086/508896 |
0.706 |
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| 2006 |
Delcroix M, Sajid M, Caffrey CR, Lim KC, Dvorák J, Hsieh I, Bahgat M, Dissous C, McKerrow JH. A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite. The Journal of Biological Chemistry. 281: 39316-29. PMID 17028179 DOI: 10.1074/Jbc.M607128200 |
0.404 |
|
| 2006 |
Beckham SA, Law RH, Smooker PM, Quinsey NS, Caffrey CR, McKerrow JH, Pike RN, Spithill TW. Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite. Biological Chemistry. 387: 1053-61. PMID 16895475 DOI: 10.1515/Bc.2006.130 |
0.356 |
|
| 2006 |
Wang SX, Pandey KC, Somoza JR, Sijwali PS, Kortemme T, Brinen LS, Fletterick RJ, Rosenthal PJ, McKerrow JH. Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. Proceedings of the National Academy of Sciences of the United States of America. 103: 11503-8. PMID 16864794 DOI: 10.1073/Pnas.0600489103 |
0.389 |
|
| 2006 |
MacKey ZB, Baca AM, Mallari JP, Apsel B, Shelat A, Hansell EJ, Chiang PK, Wolff B, Guy KR, Williams J, McKerrow JH. Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei Chemical Biology and Drug Design. 67: 355-363. PMID 16784460 DOI: 10.1111/J.1747-0285.2006.00389.X |
0.311 |
|
| 2006 |
DuBois KN, Abodeely M, Sajid M, Engel JC, McKerrow JH. Giardia lamblia cysteine proteases. Parasitology Research. 99: 313-6. PMID 16598471 DOI: 10.1007/S00436-006-0149-4 |
0.773 |
|
| 2006 |
Vicik R, Hoerr V, Glaser M, Schultheis M, Hansell E, McKerrow JH, Holzgrabe U, Caffrey CR, Ponte-Sucre A, Moll H, Stich A, Schirmeister T. Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents Bioorganic and Medicinal Chemistry Letters. 16: 2753-2757. PMID 16516467 DOI: 10.1016/J.Bmcl.2006.02.026 |
0.407 |
|
| 2006 |
McKerrow J. World Class Parasites: Vol. X, Schistosomiasis Emerging Infectious Diseases. 12: 535-535. DOI: 10.3201/Eid1203.051537 |
0.358 |
|
| 2005 |
Barr SC, Warner KL, Kornreic BG, Piscitelli J, Wolfe A, Benet L, McKerrow JH. A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi Antimicrobial Agents and Chemotherapy. 49: 5160-5161. PMID 16304193 DOI: 10.1128/Aac.49.12.5160-5161.2005 |
0.322 |
|
| 2005 |
McKerrow JH. Designing drugs for parasitic diseases of the developing world Plos Medicine. 2: 0712-0714. PMID 16120007 DOI: 10.1371/Journal.Pmed.0020210 |
0.333 |
|
| 2005 |
Knudsen GM, Medzihradszky KF, Lim KC, Hansell E, McKerrow JH. Proteomic analysis of Schistosoma mansoni cercarial secretions. Molecular & Cellular Proteomics : McP. 4: 1862-75. PMID 16112986 DOI: 10.1074/Mcp.M500097-Mcp200 |
0.347 |
|
| 2005 |
Pandey KC, Wang SX, Sijwali PS, Lau AL, McKerrow JH, Rosenthal PJ. The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif Proceedings of the National Academy of Sciences of the United States of America. 102: 9138-9143. PMID 15964982 DOI: 10.1073/Pnas.0502368102 |
0.423 |
|
| 2005 |
Dvořák J, Delcroix M, Rossi A, Vopálenský V, Pospíšek M, Šedinová M, Mikeš L, Sajid M, Sali A, McKerrow JH, Horák P, Caffrey CR. Multiple cathepsin B isoforms in schistosomula of Trichobilharzia regenti: Identification, characterisation and putative role in migration and nutrition International Journal For Parasitology. 35: 895-910. PMID 15950230 DOI: 10.1016/J.Ijpara.2005.02.018 |
0.422 |
|
| 2005 |
Caffrey CR, Placha L, Barinka C, Hradilek M, Dostál J, Sajid M, McKerrow JH, Majer P, Konvalinka J, Vondráŝek J. Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors Biological Chemistry. 386: 339-349. PMID 15899696 DOI: 10.1515/Bc.2005.041 |
0.403 |
|
| 2005 |
Wippersteg V, Sajid M, Walshe D, Khiem D, Salter JP, McKerrow JH, Grevelding CG, Caffrey CR. Biolistic transformation of Schistosoma mansoni with 5' flanking regions of two peptidase genes promotes tissue-specific expression. International Journal For Parasitology. 35: 583-9. PMID 15862572 DOI: 10.1016/J.Ijpara.2005.02.002 |
0.714 |
|
| 2005 |
Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain. Bioorganic & Medicinal Chemistry Letters. 15: 121-3. PMID 15582423 DOI: 10.1016/J.Bmcl.2004.10.023 |
0.389 |
|
| 2004 |
Guiliano DB, Hong X, McKerrow JH, Blaxter ML, Oksov Y, Liu J, Ghedin E, Lustigman S. A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodeling. Molecular and Biochemical Parasitology. 136: 227-42. PMID 15478801 DOI: 10.1016/J.Molbiopara.2004.03.015 |
0.365 |
|
| 2004 |
Götz MG, Caffrey CR, Hansell E, McKerrow JH, Powers JC. Peptidyl allyl sulfones: A new class of inhibitors for clan CA cysteine proteases Bioorganic and Medicinal Chemistry. 12: 5203-5211. PMID 15351403 DOI: 10.1016/J.Bmc.2004.07.016 |
0.323 |
|
| 2004 |
Mackey ZB, O'Brien TC, Greenbaum DC, Blank RB, McKerrow JH. A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei. The Journal of Biological Chemistry. 279: 48426-33. PMID 15326171 DOI: 10.1074/Jbc.M402470200 |
0.815 |
|
| 2004 |
Debnath A, Das P, Sajid M, McKerrow JH. Identification of genomic responses to collagen binding by trophozoites of Entamoeba histolytica Journal of Infectious Diseases. 190: 448-457. PMID 15243916 DOI: 10.1086/422323 |
0.371 |
|
| 2004 |
Williamson AL, Lecchi P, Turk BE, Choe Y, Hotez PJ, McKerrow JH, Cantley LC, Sajid M, Craik CS, Loukas A. A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms. The Journal of Biological Chemistry. 279: 35950-7. PMID 15199048 DOI: 10.1074/Jbc.M405842200 |
0.366 |
|
| 2004 |
Mahmoudzadeh-Niknam H, McKerrow JH. Leishmania tropica: Cysteine proteases are essential for growth and pathogenicity Experimental Parasitology. 106: 158-163. PMID 15172223 DOI: 10.1016/J.Exppara.2004.03.005 |
0.389 |
|
| 2004 |
Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. Journal of Medicinal Chemistry. 47: 3212-9. PMID 15163200 DOI: 10.1021/Jm030549J |
0.428 |
|
| 2004 |
Caffrey CR, McKerrow JH, Salter JP, Sajid M. Blood 'n' guts: an update on schistosome digestive peptidases. Trends in Parasitology. 20: 241-8. PMID 15105025 DOI: 10.1016/J.Pt.2004.03.004 |
0.746 |
|
| 2004 |
Ekici OD, Götz MG, James KE, Li ZZ, Rukamp BJ, Asgian JL, Caffrey CR, Hansell E, Dvorák J, McKerrow JH, Potempa J, Travis J, Mikolajczyk J, Salvesen GS, Powers JC. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. Journal of Medicinal Chemistry. 47: 1889-92. PMID 15055989 DOI: 10.1021/Jm049938J |
0.308 |
|
| 2004 |
Davies SJ, Lim KC, Blank RB, Kim JH, Lucas KD, Hernandez DC, Sedgwick JD, McKerrow JH. Involvement of TNF in limiting liver pathology and promoting parasite survival during schistosome infection. International Journal For Parasitology. 34: 27-36. PMID 14711587 DOI: 10.1016/J.Ijpara.2003.10.010 |
0.711 |
|
| 2003 |
James KE, Götz MG, Caffrey CR, Hansell E, Carter W, Barrett AJ, McKerrow JH, Powers JC. Aza-peptide epoxides: potent and selective inhibitors of Schistosoma mansoni and pig kidney legumains (asparaginyl endopeptidases). Biological Chemistry. 384: 1613-8. PMID 14719804 DOI: 10.1515/Bc.2003.179 |
0.339 |
|
| 2003 |
Davies SJ, McKerrow JH. Developmental plasticity in schistosomes and other helminths. International Journal For Parasitology. 33: 1277-84. PMID 13678642 DOI: 10.1016/S0020-7519(03)00161-9 |
0.3 |
|
| 2003 |
Sajid M, McKerrow JH, Hansell E, Mathieu MA, Lucas KD, Hsieh I, Greenbaum D, Bogyo M, Salter JP, Lim KC, Franklin C, Kim JH, Caffrey CR. Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase. Molecular and Biochemical Parasitology. 131: 65-75. PMID 12967713 DOI: 10.1016/S0166-6851(03)00194-4 |
0.769 |
|
| 2003 |
Nkemngu NJ, Grande R, Hansell E, McKerrow JH, Caffrey CR, Steverding D. Improved trypanocidal activities of cathepsin L inhibitors International Journal of Antimicrobial Agents. 22: 155-159. PMID 12927956 DOI: 10.1016/S0924-8579(03)00096-7 |
0.365 |
|
| 2003 |
Que X, Kim SH, Sajid M, Eckmann L, Dinarello CA, McKerrow JH, Reed SL. A surface amebic cysteine proteinase inactivates interleukin-18. Infection and Immunity. 71: 1274-80. PMID 12595442 DOI: 10.1128/Iai.71.3.1274-1280.2003 |
0.363 |
|
| 2002 |
Du X, Guo C, Hansell E, Doyle PS, Caffrey CR, Holler TP, McKerrow JH, Cohen FE. Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain. Journal of Medicinal Chemistry. 45: 2695-707. PMID 12061873 DOI: 10.1021/Jm010459J |
0.42 |
|
| 2002 |
Salter JP, Choe Y, Albrecht H, Franklin C, Lim KC, Craik CS, McKerrow JH. Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes. The Journal of Biological Chemistry. 277: 24618-24. PMID 11986325 DOI: 10.1074/Jbc.M202364200 |
0.749 |
|
| 2002 |
Caffrey CR, Salter JP, Lucas KD, Khiem D, Hsieh I, Lim KC, Ruppel A, McKerrow JH, Sajid M. SmCB2, a novel tegumental cathepsin B from adult Schistosoma mansoni. Molecular and Biochemical Parasitology. 121: 49-61. PMID 11985862 DOI: 10.1016/S0166-6851(02)00022-1 |
0.764 |
|
| 2002 |
Mckerrow JH, Salter J. Invasion of skin by Schistosoma cercariae. Trends in Parasitology. 18: 193-195. PMID 11983589 DOI: 10.1016/S1471-4922(02)02309-7 |
0.74 |
|
| 2002 |
Caffrey CR, Schanz M, Nkemngu NJ, Nkemgu-Njinkeng J, Brush M, Hansell E, Cohen FE, Flaherty TM, McKerrow JH, Steverding D. Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei. International Journal of Antimicrobial Agents. 19: 227-31. PMID 11932146 DOI: 10.1016/S0924-8579(01)00488-5 |
0.345 |
|
| 2002 |
Sajid M, McKerrow JH. Cysteine proteases of parasitic organisms Molecular and Biochemical Parasitology. 120: 1-21. PMID 11849701 DOI: 10.1016/S0166-6851(01)00438-8 |
0.435 |
|
| 2002 |
Que X, Brinen LS, Perkins P, Herdman S, Hirata K, Torian BE, Rubin H, McKerrow JH, Reed SL. Cysteine proteinases from distinct cellular compartments are recruited to phagocytic vesicles by Entamoeba histolytica. Molecular and Biochemical Parasitology. 119: 23-32. PMID 11755183 DOI: 10.1016/S0166-6851(01)00387-5 |
0.392 |
|
| 2001 |
Caffrey CR, Hansell E, Lucas KD, Brinen LS, Alvarez Hernandez A, Cheng J, Gwaltney SL, Roush WR, Stierhof YD, Bogyo M, Steverding D, McKerrow JH. Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense. Molecular and Biochemical Parasitology. 118: 61-73. PMID 11704274 DOI: 10.1016/S0166-6851(01)00368-1 |
0.432 |
|
| 2001 |
Davies SJ, Grogan JL, Blank RB, Lim KC, Locksley RM, McKerrow JH. Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes. Science (New York, N.Y.). 294: 1358-61. PMID 11701932 DOI: 10.1126/Science.1064462 |
0.733 |
|
| 2001 |
Lecaille F, Cotton J, McKerrow JH, Ferrer-Di Martino M, Boll-Bataillé E, Gauthier F, Lalmanach G. Reversible inhibition of cathepsin L-like proteases by 4-mer pseudopeptides. Febs Letters. 507: 362-6. PMID 11696372 DOI: 10.1016/S0014-5793(01)03008-3 |
0.333 |
|
| 2001 |
Roush WR, Cheng J, Knapp-Reed B, Alvarez-Hernandez A, McKerrow JH, Hansell E, Engel JC. Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain. Bioorganic & Medicinal Chemistry Letters. 11: 2759-62. PMID 11591518 DOI: 10.1016/S0960-894X(01)00566-2 |
0.33 |
|
| 2001 |
Paddock CD, McKerrow JH, Hansell E, Foreman KW, Hsieh I, Marshall N. Identification, cloning, and recombinant expression of procalin, a major triatomine allergen Journal of Immunology. 167: 2694-2699. PMID 11509613 DOI: 10.4049/Jimmunol.167.5.2694 |
0.301 |
|
| 2000 |
Brinen LS, Que X, McKerrow JH, Reed SL. Homology modeling of Entamoeba histolytica cysteine proteinases reveals the basis for cathepsin L-like structure with cathepsin B-like specificity. Archives of Medical Research. 31: S63-4. PMID 11070225 DOI: 10.1016/S0188-4409(00)00154-5 |
0.341 |
|
| 2000 |
Troeberg L, Chen X, Flaherty TM, Morty RE, Cheng M, Hua H, Springer C, McKerrow JH, Kenyon GL, Lonsdale-Eccles JD, Coetzer TH, Cohen FE. Chalcone, acyl hydrazide, and related amides kill cultured Trypanosoma brucei brucei. Molecular Medicine (Cambridge, Mass.). 6: 660-9. PMID 11055585 DOI: 10.1007/Bf03402046 |
0.401 |
|
| 2000 |
Brinen LS, Hansell E, Cheng J, Roush WR, McKerrow JH, Fletterick RJ. A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure (London, England : 1993). 8: 831-40. PMID 10997902 DOI: 10.1016/S0969-2126(00)00173-8 |
0.395 |
|
| 2000 |
Salter JP, Lim KC, Hansell E, Hsieh I, McKerrow JH. Schistosome invasion of human skin and degradation of dermal elastin are mediated by a single serine protease. The Journal of Biological Chemistry. 275: 38667-73. PMID 10993899 DOI: 10.1074/Jbc.M006997200 |
0.767 |
|
| 2000 |
Du X, Hansell E, Engel JC, Caffrey CR, Cohen FE, McKerrow JH. Aryl ureas represent a new class of anti-trypanosomal agents. Chemistry & Biology. 7: 733-42. PMID 10980453 DOI: 10.1016/S1074-5521(00)00018-1 |
0.396 |
|
| 2000 |
McKerrow JH, Bhargava V, Hansell E, Huling S, Kuwahara T, Matley M, Coussens L, Warren R. A functional proteomics screen of proteases in colorectal carcinoma Molecular Medicine (Cambridge, Mass.). 6: 450-460. PMID 10952024 DOI: 10.1007/Bf03401787 |
0.35 |
|
| 2000 |
Caffrey CR, Mathieu MA, Gaffney AM, Salter JP, Sajid M, Lucas KD, Franklin C, Bogyo M, McKerrow JH. Identification of a cDNA encoding an active asparaginyl endopeptidase of Schistosoma mansoni and its expression in Pichia pastoris. Febs Letters. 466: 244-8. PMID 10682836 DOI: 10.1016/S0014-5793(99)01798-6 |
0.74 |
|
| 2000 |
Roush WR, Hernandez AA, McKerrow JH, Selzer PM, Hansell E, Engel JC. Design, synthesis and evaluation of D-Homophenylalanyl epoxysuccinate inhibitors of the trypanosomal cysteine protease cruzain Tetrahedron. 56: 9747-9762. DOI: 10.1016/S0040-4020(00)00882-6 |
0.324 |
|
| 2000 |
McKerrow JH, Caffrey CR, Salter JP. Parasite Proteases as Targets for Therapy Handbook of Experimental Pharmacology. 140: 189-204. DOI: 10.1007/978-3-642-57092-6_10 |
0.745 |
|
| 1999 |
Loer CM, Davidson B, Mckerrow J. A phenylalanine hydroxylase gene from the nematode C. elegans is expressed in the hypodermis. Journal of Neurogenetics. 13: 157-80. PMID 10928216 DOI: 10.3109/01677069909083472 |
0.32 |
|
| 1999 |
Britton C, Redmond DL, Knox DP, McKerrow JH, Barry JD. Identification of promoter elements of parasite nematode genes in transgenic Caenorhabditis elegans. Molecular and Biochemical Parasitology. 103: 171-81. PMID 10551361 DOI: 10.1016/S0166-6851(99)00121-8 |
0.351 |
|
| 1999 |
Selzer PM, Pingel S, Hsieh I, Ugele B, Chan VJ, Engel JC, Bogyo M, Russell DG, Sakanari JA, Mckerrow JH. Cysteine protease inhibitors as chemotherapy: Lessons from a parasite target Proceedings of the National Academy of Sciences of the United States of America. 96: 11015-11022. PMID 10500116 DOI: 10.1073/Pnas.96.20.11015 |
0.468 |
|
| 1999 |
McKerrow JH. Development of cysteine protease inhibitors as chemotherapy for parasitic diseases: insights on safety, target validation, and mechanism of action. International Journal For Parasitology. 29: 833-837. PMID 10480720 DOI: 10.1016/S0020-7519(99)00044-2 |
0.459 |
|
| 1999 |
Lim KC, Sun E, Bahgat M, Bucks D, Guy R, Hinz RS, Cullander C, McKerrow JH. Blockage of skin invasion by schistosome cercariae by serine protease inhibitors. The American Journal of Tropical Medicine and Hygiene. 60: 487-92. PMID 10466982 DOI: 10.4269/Ajtmh.1999.60.487 |
0.333 |
|
| 1999 |
McKerrow JH, Engel JC, Caffrey CR. Cysteine protease inhibitors as chemotherapy for parasitic infections Bioorganic and Medicinal Chemistry. 7: 639-644. PMID 10353643 DOI: 10.1016/S0968-0896(99)00008-5 |
0.476 |
|
| 1999 |
Huete-Pérez JA, Engel JC, Brinen LS, Mottram JC, McKerrow JH. Protease trafficking in two primitive eukaryotes is mediated by a prodomain protein motif. The Journal of Biological Chemistry. 274: 16249-56. PMID 10347181 DOI: 10.1074/Jbc.274.23.16249 |
0.348 |
|
| 1999 |
Troeberg L, Morty RE, Pike RN, Lonsdale-Eccles JD, Palmer JT, McKerrow JH, Coetzer TH. Cysteine proteinase inhibitors kill cultured bloodstream forms of Trypanosoma brucei brucei. Experimental Parasitology. 91: 349-55. PMID 10092479 DOI: 10.1006/Expr.1998.4386 |
0.367 |
|
| 1999 |
Chan VJ, Selzer PM, McKERROW JH, Sakanari JA. Expression and alteration of the S2 subsite of the Leishmania major cathepsin B-like cysteine protease. Biochemical Journal. 340: 113-117. DOI: 10.1042/Bj3400113 |
0.351 |
|
| 1998 |
Scheidt KA, Roush WR, McKerrow JH, Selzer PM, Hansell E, Rosenthal PJ. Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors. Bioorganic & Medicinal Chemistry. 6: 2477-94. PMID 9925304 DOI: 10.1016/S0968-0896(98)80022-9 |
0.379 |
|
| 1998 |
Engel JC, Doyle PS, Hsieh I, McKerrow JH. Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection Journal of Experimental Medicine. 188: 725-734. PMID 9705954 DOI: 10.1084/Jem.188.4.725 |
0.361 |
|
| 1998 |
Stoka V, McKerrow JH, Cazzulo JJ, Turk V. Substrate inhibition of cruzipain is not affected by the C-terminal domain Febs Letters. 429: 129-133. PMID 9650575 DOI: 10.1016/S0014-5793(98)00532-8 |
0.323 |
|
| 1998 |
Roush WR, Gwaltney SL, Cheng J, Scheidt KA, McKerrow JH, Hansell E. Vinyl sulfonate esters and vinyl sulfonamides: Potent, irreversible inhibitors of cysteine proteases [10] Journal of the American Chemical Society. 120: 10994-10995. DOI: 10.1021/Ja981792O |
0.336 |
|
| 1997 |
McKERROW JH. Cytokine induction and exploitation in schistosome infections. Parasitology. 115: 107-112. PMID 9571696 DOI: 10.1017/S0031182097001765 |
0.358 |
|
| 1997 |
Selzer PM, Chen X, Chan VJ, Cheng M, Kenyon GL, Kuntz ID, Sakanari JA, Cohen FE, McKerrow JH. Leishmania major: molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors. Experimental Parasitology. 87: 212-21. PMID 9371086 DOI: 10.1006/Expr.1997.4220 |
0.386 |
|
| 1997 |
Ward W, Alvarado L, Rawlings ND, Engel JC, Franklin C, McKerrow JH. A primitive enzyme for a primitive cell: the protease required for excystation of Giardia. Cell. 89: 437-44. PMID 9150143 DOI: 10.1016/S0092-8674(00)80224-X |
0.427 |
|
| 1996 |
McKerrow JH. Parasitic infections--molecular diagnosis and rational drug design. Biologicals. 24: 207-209. PMID 8978920 DOI: 10.1006/Biol.1996.0028 |
0.325 |
|
| 1996 |
Wasilewski MM, Lim KC, Phillips J, McKerrow JH. Cysteine protease inhibitors block schistosome hemoglobin degradation in vitro and decrease worm burden and egg production in vivo Molecular and Biochemical Parasitology. 81: 179-189. PMID 8898333 DOI: 10.1016/0166-6851(96)02703-X |
0.422 |
|
| 1996 |
Li R, Chen X, Gong B, Selzer PM, Li Z, Davidson E, Kurzban G, Miller RE, Nuzum EO, McKerrow JH, Fletterick RJ, Gillmor SA, Craik CS, Kuntz ID, Cohen FE, et al. Structure-based design of parasitic protease inhibitors. Bioorganic & Medicinal Chemistry. 4: 1421-7. PMID 8894100 DOI: 10.1016/0968-0896(96)00136-8 |
0.394 |
|
| 1995 |
McKerrow JH, McGrath ME, Engel JC. The cysteine protease of Trypanosoma cruzi as a model for antiparasite drug design. Parasitology Today (Personal Ed.). 11: 279-82. PMID 15275323 DOI: 10.1016/0169-4758(95)80039-5 |
0.372 |
|
| 1995 |
Tume C, Sun E, Titanji V, Bathurst I, Barr P, Hough M, Weiss N, Chakravarti B, Wahi M, Lackey A, Staunton C, Lustigman S, Mckerrow JH. Onchocerca volvulus: Identification and Characterization of an Immunogenic Eggshell Protein (Oveg 1) Experimental Parasitology. 81: 445-452. PMID 8542985 DOI: 10.1006/Expr.1995.1137 |
0.348 |
|
| 1995 |
McGrath ME, Eakin AE, Engel JC, McKerrow JH, Craik CS, Fletterick RJ. The crystal structure of cruzain: a therapeutic target for Chagas' disease. Journal of Molecular Biology. 247: 251-9. PMID 7707373 DOI: 10.1006/Jmbi.1994.0137 |
0.428 |
|
| 1995 |
Brindley PJ, Gam AA, McKerrow JH, Neva FA. Ss40: the zinc endopeptidase secreted by infective larvae of Strongyloides stercoralis. Experimental Parasitology. 80: 1-7. PMID 7529715 DOI: 10.1006/Expr.1995.1001 |
0.343 |
|
| 1995 |
Eakin AE, McKerrow JH, Craik CS. A Cysteine Protease is a Target for the Enzyme Structure-Based Design of Antiparasitic Drugs Drug Information Journal. 29: 1501S-1517S. DOI: 10.1177/00928615950290S102 |
0.431 |
|
| 1995 |
McKerrow JH. Cysteine proteases of parasites: A remarkable diversity of function Perspectives in Drug Discovery and Design. 2: 437-444. DOI: 10.1007/Bf02172036 |
0.425 |
|
| 1994 |
Mitro K, Bhagavathiammai A, Zhou O, Bobbett G, Mckerrow JH, Chokshi R, Chokshi B, James ER. Partial characterization of the proteolytic secretions of Acanthamoeba polyphaga Experimental Parasitology. 78: 377-385. PMID 8206136 DOI: 10.1006/Expr.1994.1041 |
0.323 |
|
| 1994 |
Aldape K, Huizinga H, Bouvier J, McKerrow J. Naegleria fowleri: Characterization of a Secreted Histolytic Cysteine Protease Experimental Parasitology. 78: 230-241. PMID 8119377 DOI: 10.1006/Expr.1994.1023 |
0.411 |
|
| 1993 |
Ring CS, Sun E, McKerrow JH, Lee GK, Rosenthal PJ, Kuntz ID, Cohen FE. Structure-based inhibitor design by using protein models for the development of antiparasitic agents. Proceedings of the National Academy of Sciences of the United States of America. 90: 3583-7. PMID 8475107 DOI: 10.1073/Pnas.90.8.3583 |
0.403 |
|
| 1993 |
Harth G, Andrews N, Mills AA, Engel JC, Smith R, McKerrow JH. Peptide-fluoromethyl ketones arrest intracellular replication and intercellular transmission of Trypanosoma cruzi. Molecular and Biochemical Parasitology. 58: 17-24. PMID 8459830 DOI: 10.1016/0166-6851(93)90086-D |
0.455 |
|
| 1993 |
Hong X, Bouvier J, Wong MM, Yamagata GYL, Mckerrow JH. Brugia pahangi: Identification and Characterization of an Aminopeptidase Associated with Larval Molting Experimental Parasitology. 76: 127-133. PMID 8454021 DOI: 10.1006/Expr.1993.1015 |
0.341 |
|
| 1993 |
McKerrow JH, Sun E, Rosenthal PJ, Bouvier J. The Proteases and Pathogenicity of Parasitic Protozoa Annual Review of Microbiology. 47: 821-853. PMID 8257117 DOI: 10.1146/Annurev.Mi.47.100193.004133 |
0.441 |
|
| 1992 |
McKerrow JH, Ritter D. Schistosomes and host TNF. Parasitology Today (Personal Ed.). 8: 411-2. PMID 15463555 DOI: 10.1016/0169-4758(92)90192-5 |
0.306 |
|
| 1992 |
Yuan L, Craig SP, McKerrow JH, Wang CC. Steady-state kinetics of the schistosomal hypoxanthine-guanine phosphoribosyltransferase. Biochemistry. 31: 806-810. PMID 1731938 DOI: 10.1021/Bi00118A024 |
0.337 |
|
| 1992 |
Fishelson Z, Amiri P, Friend DS, Marikovsky M, Petitt M, Newport G, Mckerrow JH. Schistosoma mansoni: Cell-specific expression and secretion of a serine protease during development of cercariae Experimental Parasitology. 75: 87-98. PMID 1639166 DOI: 10.1016/0014-4894(92)90124-S |
0.399 |
|
| 1992 |
Ray C, McKerrow JH. Gut-specific and developmental expression of a Caenorhabditis elegans cysteine protease gene. Molecular and Biochemical Parasitology. 51: 239-49. PMID 1574082 DOI: 10.1016/0166-6851(92)90074-T |
0.358 |
|
| 1992 |
Amiri P, Locksley RM, Parslow TG, Sadick M, Rector E, Ritter D, McKerrow JH. Tumour necrosis factor alpha restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice. Nature. 356: 604-7. PMID 1560843 DOI: 10.1038/356604A0 |
0.365 |
|
| 1991 |
McKerrow JH, Newport G, Fishelson Z. Recent insights into the structure and function of a larval proteinase involved in host infection by a multicellular parasite. Experimental Biology and Medicine. 197: 119-124. PMID 2031051 DOI: 10.3181/00379727-197-43233 |
0.372 |
|
| 1991 |
Craig SP, Yuan L, Kuntz DA, McKerrow JH, Wang CC. High level expression in Escherichia coli of soluble, enzymatically active schistosomal hypoxanthine/guanine phosphoribosyltransferase and trypanosomal ornithine decarboxylase. Proceedings of the National Academy of Sciences of the United States of America. 88: 2500-2504. PMID 2006185 DOI: 10.1073/Pnas.88.6.2500 |
0.341 |
|
| 1991 |
Cohen FE, Gregoret LM, Amiri P, Aldape K, Railey J, McKerrow JH. Arresting tissue invasion of a parasite by protease inhibitors chosen with the aid of computer modeling Biochemistry. 30: 11221-11229. PMID 1958659 DOI: 10.1021/Bi00111A005 |
0.387 |
|
| 1990 |
Eakin AE, Bouvier J, Sakanari JA, Craik CS, McKerrow JH. Amplification and sequencing of genomic DNA fragments encoding cysteine proteases from protozoan parasites. Molecular and Biochemical Parasitology. 39: 1-8. PMID 2406590 DOI: 10.1016/0166-6851(90)90002-4 |
0.343 |
|
| 1990 |
McKerrow JH, Brindley P, Brown M, Gam AA, Staunton C, Neva FA. Strongyloides stercoralis: identification of a protease that facilitates penetration of skin by the infective larvae. Experimental Parasitology. 70: 134-43. PMID 2137091 DOI: 10.1016/0014-4894(90)90094-S |
0.411 |
|
| 1990 |
Apodaca G, McKerrow JH. Expression of proteolytic activity by cultures of Trichophyton rubrum. Journal of Medical and Veterinary Mycology : Bi-Monthly Publication of the International Society For Human and Animal Mycology. 28: 159-71. PMID 1696313 DOI: 10.1080/02681219080000211 |
0.306 |
|
| 1989 |
Craig SP, Muralidhar MG, McKerrow JH, Wang CC. Evidence for a class of very small introns in the gene for hypoxanthine-guanine phosphoribosyltransferase in Schistosoma mansoni. Nucleic Acids Research. 17: 1635-47. PMID 2701934 DOI: 10.1093/Nar/17.4.1635 |
0.304 |
|
| 1989 |
Apodaca G, McKerrow JH. Purification and characterization of a 27,000-Mr extracellular proteinase from Trichophyton rubrum. Infection and Immunity. 57: 3072-80. PMID 2674015 DOI: 10.1128/Iai.57.10.3072-3080.1989 |
0.323 |
|
| 1989 |
Rosenthal PJ, McKerrow JH, Rasnick D, Leech JH. Plasmodium falciparum: inhibitors of lysosomal cysteine proteinases inhibit a trophozoite proteinase and block parasite development. Molecular and Biochemical Parasitology. 35: 177-183. PMID 2671722 DOI: 10.1016/0166-6851(89)90120-5 |
0.379 |
|
| 1989 |
Sakanari JA, Staunton CE, Eakin AE, Craik CS, McKerrow JH. Serine proteases from nematode and protozoan parasites: isolation of sequence homologs using generic molecular probes. Proceedings of the National Academy of Sciences of the United States of America. 86: 4863-7. PMID 2662185 DOI: 10.1073/Pnas.86.13.4863 |
0.407 |
|
| 1989 |
Robertson BD, Bianco AT, Mckerrow JH, Maizels RM. Toxocara canis: proteolytic enzymes secreted by the infective larvae in vitro. Experimental Parasitology. 69: 30-36. PMID 2659374 DOI: 10.1016/0014-4894(89)90168-9 |
0.361 |
|
| 1989 |
Lackey A, James ER, Sakanari JA, Resnick SD, Brown M, Bianco AE, McKerrow JH. Extracellular proteases of Onchocerca. Experimental Parasitology. 68: 176-185. PMID 2647506 DOI: 10.1016/0014-4894(89)90095-7 |
0.327 |
|
| 1989 |
Reed SL, Keene WE, McKerrow JH. Thiol proteinase expression and pathogenicity of Entamoeba histolytica. Journal of Clinical Microbiology. 27: 2772-7. PMID 2556432 DOI: 10.1128/Jcm.27.12.2772-2777.1989 |
0.314 |
|
| 1989 |
Apodaca G, McKerrow JH. Regulation of Trichophyton rubrum proteolytic activity. Infection and Immunity. 57: 3081-90. PMID 2476398 DOI: 10.1128/Iai.57.10.3081-3090.1989 |
0.322 |
|
| 1988 |
Craig SP, McKerrow JH, Newport GR, Wang CC. Analysis of cDNA encoding the hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) of Schistosoma mansoni; a putative target for chemotherapy Nucleic Acids Research. 16: 7087-7101. PMID 3136439 DOI: 10.1093/Nar/16.14.7087 |
0.361 |
|
| 1988 |
Rosenthal PJ, McKerrow JH, Aikawa M, Nagasawa H, Leech JH. A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum. Journal of Clinical Investigation. 82: 1560-1566. PMID 3053784 DOI: 10.1172/Jci113766 |
0.383 |
|
| 1988 |
Amiri P, Sakanari J, Basch P, Newport G, McKerrow JH. The Schistosomatium douthitti cercarial elastase is biochemically and structurally distinct from that of Schistosoma mansoni. Molecular and Biochemical Parasitology. 28: 113-120. PMID 2452979 DOI: 10.1016/0166-6851(88)90058-8 |
0.332 |
|
| 1987 |
Newport GR, Harrison RA, McKerrow J, Tarr P, Kallestad J, Agabian N. Molecular cloning of Schistosoma mansoni myosin. Molecular and Biochemical Parasitology. 26: 29-38. PMID 3431565 DOI: 10.1016/0166-6851(87)90127-7 |
0.33 |
|
| 1987 |
Resnick S, Pappagianis D, McKerrow JH. Proteinase production by the parasitic cycle of the pathogenic fungus Coccidioides immitis. Infection and Immunity. 55: 2807-2815. PMID 3312014 DOI: 10.1128/Iai.55.11.2807-2815.1987 |
0.368 |
|
| 1987 |
Banda MJ, Werb Z, McKerrow JH. Elastin degradation Methods in Enzymology. 144: 288-305. PMID 3306285 DOI: 10.1016/0076-6879(87)44184-0 |
0.329 |
|
| 1987 |
Rosenthal PJ, Kim K, McKerrow JH, Leech JH. Identification of three stage-specific proteinases of Plasmodium falciparum. Journal of Experimental Medicine. 166: 816-821. PMID 3305763 DOI: 10.1084/Jem.166.3.816 |
0.424 |
|
| 1986 |
Lindquist RN, Senft AW, Petitt M, McKerrow J. Schistosoma mansoni: purification and characterization of the major acidic proteinase from adult worms. Experimental Parasitology. 61: 398-404. PMID 3519269 DOI: 10.1016/0014-4894(86)90196-7 |
0.311 |
|
| 1986 |
Keene WE, Petitt MG, Allen S, McKERROW JH. The major neutral proteinase of Entamoeba histolytica. Journal of Experimental Medicine. 163: 536-549. PMID 2869098 DOI: 10.1084/Jem.163.3.536 |
0.347 |
|
| 1985 |
Asahi M, Lindquist R, Fukuyama K, Apodaca G, Epstein WL, McKerrow JH. Purification and characterization of major extracellular proteinases from Trichophyton rubrum. The Biochemical Journal. 232: 139-44. PMID 3910025 DOI: 10.1042/Bj2320139 |
0.352 |
|
| 1985 |
Pino-Heiss S, Brown M, McKerrow JH. Schistosoma mansoni: degradation of host extracellular matrix by eggs and miracidia. Experimental Parasitology. 59: 217-221. PMID 3882446 DOI: 10.1016/0014-4894(85)90075-X |
0.301 |
|
| 1985 |
McKerrow JH, Jeong KH, Beckstead JH. Enzyme histochemical comparison of biomphalaria glabrata amebocytes with human granuloma macrophages. Journal of Leukocyte Biology. 37: 341-347. PMID 2981947 DOI: 10.1002/Jlb.37.3.341 |
0.343 |
|
| 1984 |
Dovey HF, McKerrow JH, Wang CC. Purine salvage in Schistosoma mansoni schistosomules Molecular and Biochemical Parasitology. 11: 157-167. PMID 6431283 DOI: 10.1016/0166-6851(84)90062-8 |
0.332 |
|
| 1982 |
Tzeng S, McKerrow JH, Jeong K, Fukuyama K, Epstein WL. Partial purification and characterization of an inhibitor from newborn-rat epidermis with activity against the proteinase of Schistosoma mansoni cercariae. The Biochemical Journal. 207: 479-84. PMID 7165704 DOI: 10.1042/Bj2070479 |
0.389 |
|
| 1982 |
Werb Z, Banda MJ, Mckerrow JH, Sandhaus RA. Elastases and Elastin Degradation Journal of Investigative Dermatology. 79: 154-159. DOI: 10.1038/Jid.1982.28 |
0.368 |
|
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