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Arthur Melnick - Publications

Affiliations: 
University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
Area:
Philosophy
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95 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kawabata KC, Zong H, Meydan C, Wyman S, Wouters BJ, Sugita M, Goswami S, Albert M, Yip W, Roboz GJ, Chen Z, Delwel R, Carroll MP, Mason C, Melnick A, et al. BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells. Blood. PMID 32911532 DOI: 10.1182/Blood.2019001745  0.312
2020 Rosikiewicz W, Chen X, Dominguez PM, Ghamlouch H, Aoufouchi S, Bernard OA, Melnick A, Li S. TET2 deficiency reprograms the germinal center B cell epigenome and silences genes linked to lymphomagenesis. Science Advances. 6: eaay5872. PMID 32596441 DOI: 10.1126/Sciadv.Aay5872  0.321
2019 Hurtz C, Chan LN, Geng H, Ballabio E, Xiao G, Deb G, Khoury H, Chen CW, Armstrong SA, Chen J, Ernst P, Melnick A, Milne T, Müschen M. Rationale for targeting BCL6 in -rearranged acute lymphoblastic leukemia. Genes & Development. PMID 31395741 DOI: 10.1101/Gad.327593.119  0.319
2019 Chan LN, Hurtz C, Geng H, Ballabio E, Xiao G, Deb G, Khoury H, Armstrong SA, Ernst P, Melnick A, Milne TA, Müschen M. Rationale for Targeting BCL6 in MLL-Rearranged B-ALL Blood. 134: 1239-1239. DOI: 10.1182/Blood-2019-131565  0.303
2018 Lu X, Fernando T, Lossos C, Yusufova N, Liu F, Fontán L, Durant M, Geng H, Melnick J, Luo Y, Vega F, Moy V, Inghirami G, Nimer S, Melnick AM, et al. PRMT5 interacts with the BCL6 oncoprotein and is required for germinal center formation and lymphoma cell survival. Blood. PMID 30082494 DOI: 10.1182/Blood-2018-02-831438  0.319
2018 Teater M, Dominguez PM, Redmond D, Chen Z, Ennishi D, Scott DW, Cimmino L, Ghione P, Chaudhuri J, Gascoyne RD, Aifantis I, Inghirami G, Elemento O, Melnick A, Shaknovich R. AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis. Nature Communications. 9: 222. PMID 29335468 DOI: 10.1038/S41467-017-02595-W  0.318
2018 Melnick A. Abstract IA11: Epigenetic mechanisms in pathogenesis and targeted therapy for B-cell lymphomas Clinical Cancer Research. 24. DOI: 10.1158/1557-3265.Tcm17-Ia11  0.333
2018 Mondello P, Teater M, Fontan L, Durant M, Stanchina Ed, Inghirami G, Green M, Melnick A. Abstract 797: Targeting HDAC3 reactivates immunosurveillance and enhances immunocheckpoint activity in B-cell lymphoma Cancer Research. 78: 797-797. DOI: 10.1158/1538-7445.Am2018-797  0.348
2017 Valls E, Lobry C, Geng H, Wang L, Cardenas M, Rivas M, Cerchietti L, Oh P, Yang SN, Oswald E, Graham CW, Jiang Y, Hatzi K, Agirre X, Perkey E, ... ... Melnick A, et al. BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells. Cancer Discovery. PMID 28232365 DOI: 10.1158/2159-8290.Cd-16-1189  0.306
2017 Vu LP, Pickering BF, Cheng Y, Sara Z, Nguyen D, Minuesa G, Chou T, Chow A, MacKay M, Famulare C, Patel M, Garret-Bakelman F, Melnick A, Carroll M, Mason C, et al. m6a Regulates Differentiation State and mRNA Translation in Myeloid Leukemia Blood. 130: 791-791. DOI: 10.1182/BLOOD.V130.SUPPL_1.791.791  0.335
2017 Vu L, Prieto C, Amin EM, Minuesa G, Chhangawala S, Vidal MC, Krivtsov A, Chou T, Chow A, Barlowe T, Taggart J, Tivnan P, Deering RP, Chu LP, Gonen M, ... ... Melnick A, et al. Abstract IA13: RNA regulators and the control of self-renewal Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Hemmal17-Ia13  0.305
2017 Fachel AA, Jiang Y, Tam W, Muley AS, Meydan C, Agirre X, Melnick AM, Richards KL. Abstract 30: SOX9 enhancer regulator may play an oncogenic role in B-cell lymphomas Clinical Cancer Research. 23: 30-30. DOI: 10.1158/1557-3265.Hemmal17-30  0.366
2016 Cardenas MG, Oswald E, Yu W, Xue F, MacKerell AD, Melnick AM. The expanding role of the BCL6 oncoprotein as a cancer therapeutic target. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27881582 DOI: 10.1158/1078-0432.Ccr-16-2071  0.319
2016 Cardenas MG, Yu W, Beguelin W, Teater MR, Geng H, Goldstein RL, Oswald E, Hatzi K, Yang SN, Cohen J, Shaknovich R, Vanommeslaeghe K, Cheng H, Liang D, Cho HJ, ... Melnick AM, et al. Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma. The Journal of Clinical Investigation. PMID 27482887 DOI: 10.1172/Jci85795  0.302
2016 Hurtz C, Chan LN, Ballabio E, Willman CL, Carroll WL, Armstrong SA, Ernst P, Melnick A, Milne T, Müschen M. Oncogenic Feedback Activation Between BCL6 and MLL Promotes Malignant Transformation in MLL-RearrangedAcute Lymphoblastic Leukemia Blood. 128: 907-907. DOI: 10.1182/Blood.V128.22.907.907  0.316
2016 Ying H, Jiang Y, Ortega-Molina A, Geng H, McNally D, Wang L, Doane A, Agirre X, Ju H, Poloway D, Teater M, Parsa S, Ennishi D, Scott DW, Shaknovich R, ... ... Melnick A, et al. Crebbp Mutations Disrupt Dynamic Enhancer Acetylation in B-Cells, Enabling HDAC3 to Drive Lymphomagenesis Blood. 128: 735-735. DOI: 10.1182/Blood.V128.22.735.735  0.342
2016 Béguelin W, Rivas MA, Fernández MTC, Melnick A. EZH2 Enables the Proliferation of Germinal Center B Cells and DLBCL through a Rb-E2F1 Positive Feedback Loop Involving Repression of CDKN1A Blood. 128: 734-734. DOI: 10.1182/Blood.V128.22.734.734  0.319
2016 Duy C, Teater M, Garrett-Bakelman FE, Lee TC, Meydan C, Glass JL, Li M, Mohammad H, Smitheman K, Shih AH, Abdel-Wahab O, Paietta E, Tallman MS, Guzman ML, Kruger RG, ... ... Melnick A, et al. Cooperative Gene Repression By DNA Methylation and LSD1-Mediated Enhancer Inactivation in Acute Myeloid Leukemia Blood. 128: 1048-1048. DOI: 10.1182/Blood.V128.22.1048.1048  0.316
2016 Dominguez MDP, Teater M, Redmond D, Cheng Z, Chaudhuri J, Elemento O, Melnick A, Shaknovich R. AICDA Introduces Epigenetic Plasticity in Germinal Center-Derived Lymphomas and Accelerates Lymphomagenesis Blood. 128: 1045-1045. DOI: 10.1182/Blood.V128.22.1045.1045  0.342
2016 Ortega-Molina A, Boss IW, Canela A, Pan H, Jiang Y, Zhao C, Jiang M, Hu D, Lee J, Chen H, Ennishi D, Scott DW, Hother C, Liu S, Cao X, ... Melnick AM, et al. Abstract IA18: Functional characterization of the tumor suppressor lysine-specific methyltransferase KMT2D in lymphoma Cancer Research. 76. DOI: 10.1158/1538-7445.Chromepi15-Ia18  0.331
2015 Huang C, Melnick A. Mechanisms of action of BCL6 during germinal center B cell development. Science China. Life Sciences. PMID 26566802 DOI: 10.1007/S11427-015-4919-Z  0.316
2015 Verma A, Jiang Y, Du W, Fairchild L, Melnick A, Elemento O. Transcriptome sequencing reveals thousands of novel long non-coding RNAs in B cell lymphoma. Genome Medicine. 7: 110. PMID 26521025 DOI: 10.1182/Blood.V126.23.2427.2427  0.317
2015 Ortega-Molina A, Boss IW, Canela A, Pan H, Jiang Y, Zhao C, Jiang M, Hu D, Agirre X, Niesvizky I, Lee JE, Chen HT, Ennishi D, Scott DW, Mottok A, ... Melnick AM, et al. The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development. Nature Medicine. PMID 26366710 DOI: 10.1038/Nm.3943  0.332
2015 Buchner M, Park E, Geng H, Klemm L, Flach J, Passegué E, Schjerven H, Melnick A, Paietta E, Kopanja D, Raychaudhuri P, Müschen M. Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia. Nature Communications. 6: 6471. PMID 25753524 DOI: 10.1038/Ncomms7471  0.309
2015 Béguelin W, Teater M, Corcoran C, Hamline M, Gascoyne RD, Levine RL, Abdel-Wahab O, Shaknovich R, Elemento O, Bardwell VJ, Melnick A. A Chromatin Reader That Acts As a Key to Lock in and Coordinate Recruitment of Transcription Factors and a Novel Polycomb Complex to Bivalent Chromatin Thus Driving Formation of Germinal Centers and B-Cell Lymphomas Blood. 126: 434-434. DOI: 10.1182/Blood.V126.23.434.434  0.358
2015 Kraljacic-Culkjovic B, Fernando T, Goldstein R, Mctavish C, Patel J, Yang S, Tabbo F, Melnick A, Inghirami G, Borden KL, Cerchietti L. Abstract B12: EIF4E deregulation drives simultaneous expression of B-cell lymphoma oncogenes. Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Hemmal14-B12  0.309
2015 Ortega-Molina A, Boss I, Pan H, Jiang Y, Hu D, Gao X, Shaknovich R, Shilatifard A, Melnick AM, Wendel H. Abstract LB-064: Characterization of the tumor suppressor function of the lysine-specific methyltransferase KMT2D in follicular lymphoma Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Lb-064  0.312
2014 Green MR, Vicente-Dueñas C, Romero-Camarero I, Long Liu C, Dai B, González-Herrero I, García-Ramírez I, Alonso-Escudero E, Iqbal J, Chan WC, Campos-Sanchez E, Orfao A, Pintado B, Flores T, Blanco O, ... Melnick A, et al. Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma. Nature Communications. 5: 3904. PMID 24887457 DOI: 10.1038/Ncomms4904  0.34
2014 Kharabi Masouleh B, Geng H, Hurtz C, Chan LN, Logan AC, Chang MS, Huang C, Swaminathan S, Sun H, Paietta E, Melnick AM, Koeffler P, Müschen M. Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia. Proceedings of the National Academy of Sciences of the United States of America. 111: E2219-28. PMID 24821775 DOI: 10.1073/Pnas.1400958111  0.306
2014 Hatzi K, Melnick A. Breaking bad in the germinal center: How deregulation of BCL6 contributes to lymphomagenesis Trends in Molecular Medicine. 20: 343-352. PMID 24698494 DOI: 10.1016/J.Molmed.2014.03.001  0.32
2014 Huang C, Geng H, Boss I, Wang L, Melnick A. Cooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation Blood. 123: 1012-1020. PMID 24277074 DOI: 10.1182/Blood-2013-07-518605  0.321
2014 Park SM, Gönen M, Vu LP, Minuesa G, Tivnan P, Barlowe T, Taggart J, Lu Y, Deering RP, Hacohen N, Figueroa M, Paietta EM, Tallman MS, Melnick AM, Levine RL, et al. Msi2 Maintains the MLL Leukemia Stem Cell Regulatory Program Blood. 124: 836-836. DOI: 10.1182/Blood.V124.21.836.836  0.315
2014 Fernando TM, Yang SN, Huang C, Chiosis G, Cerchietti L, Melnick AM. BCL6 Mediates a Stress Tolerance Phenotype through Its BTB Domain Blood. 124: 567-567. DOI: 10.1182/Blood.V124.21.567.567  0.304
2014 Flynn RP, Goodman K, Qi J, Jing D, Panoskaltsis-Mortari A, Yi Z, Dong C, Liu X, MacDonald KPA, Hill GR, Serody JS, Murphy WJ, Luznik L, Maillard I, Koreth J, ... Melnick AM, et al. Targeting BCL6 and Germinal Centers (GCs) in Chronic Graft-Versus-Host Disease (cGVHD) Using Direct and Epigenomic Therapies Blood. 124: 535-535. DOI: 10.1182/Blood.V124.21.535.535  0.303
2014 Geng H, Hurtz C, Baumjohann D, Chen Z, Chen W, Ballabio E, Xiao G, Lee J, Deucher A, Qi Z, Huang C, Nahar R, Kweon S, Shojaee S, Chan LN, ... ... Melnick A, et al. Self-Enforcing Feedback Activation Between BCL6 and Tonic Pre-B Cell Receptor Signaling in Acute Lymphoblastic Leukemia Blood. 124: 284-284. DOI: 10.1182/Blood.V124.21.284.284  0.303
2014 Shojaee S, Cazzaniga V, Schjerven H, Buchner M, Hurtz C, Geng H, Hochhaus A, Cazzaniga G, Melnick AM, Kornblau SM, Graeber TG, Muschen M. PTEN Is Essential for Normal Cytokine Signaling and Oncogenic Transformation of Pre-B Cells Blood. 124: 262-262. DOI: 10.1182/Blood.V124.21.262.262  0.32
2014 Beguelin W, Teater M, Popovic R, Jiang Y, Cerchietti L, Shaknovich R, Gascoyne R, Levine R, Abdel-Wahab O, Licht J, Elemento O, Melnick AM. Abstract SY09-03: How deregulation of histone methyltransferases drive malignant transformation of B-cells Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Sy09-03  0.356
2013 Hatzi K, Jiang Y, Huang C, Garrett-Bakelman F, Gearhart MD, Giannopoulou EG, Zumbo P, Kirouac K, Bhaskara S, Polo JM, Kormaksson M, MacKerell AD, Xue F, Mason CE, Hiebert SW, ... Melnick A, et al. A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters. Cell Reports. 4: 578-88. PMID 23911289 DOI: 10.1016/J.Celrep.2013.06.016  0.315
2013 Swaminathan S, Huang C, Geng H, Chen Z, Harvey R, Kang H, Ng C, Titz B, Hurtz C, Sadiyah MF, Nowak D, Thoennissen GB, Rand V, Graeber TG, Koeffler HP, ... Melnick A, et al. BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint. Nature Medicine. 19: 1014-22. PMID 23852341 DOI: 10.1038/Nm.3247  0.321
2013 Bertolo C, Roa S, Sagardoy A, Mena-Varas M, Robles EF, Martinez-Ferrandis JI, Sagaert X, Tousseyn T, Orta A, Lossos IS, Amar S, Natkunam Y, Briones J, Melnick A, Malumbres R, et al. LITAF, a BCL6 target gene, regulates autophagy in mature B-cell lymphomas. British Journal of Haematology. 162: 621-30. PMID 23795761 DOI: 10.1111/Bjh.12440  0.329
2013 Béguelin W, Popovic R, Teater M, Jiang Y, Bunting KL, Rosen M, Shen H, Yang SN, Wang L, Ezponda T, Martinez-Garcia E, Zhang H, Zheng Y, Verma SK, McCabe MT, ... Melnick AM, et al. EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. Cancer Cell. 23: 677-92. PMID 23680150 DOI: 10.1016/J.Ccr.2013.04.011  0.325
2013 Sagardoy A, Martinez-Ferrandis JI, Roa S, Bunting KL, Aznar MA, Elemento O, Shaknovich R, Fontán L, Fresquet V, Perez-Roger I, Robles EF, De Smedt L, Sagaert X, Melnick A, Martinez-Climent JA. Downregulation of FOXP1 is required during germinal center B-cell function. Blood. 121: 4311-20. PMID 23580662 DOI: 10.1182/Blood-2012-10-462846  0.304
2013 De S, Shaknovich R, Riester M, Elemento O, Geng H, Kormaksson M, Jiang Y, Woolcock B, Johnson N, Polo JM, Cerchietti L, Gascoyne RD, Melnick A, Michor F. Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity. Plos Genetics. 9: e1003137. PMID 23326238 DOI: 10.1371/Journal.Pgen.1003137  0.314
2013 Masouleh BK, Geng H, Hurtz C, Huang C, Chan LN, Swaminathan S, Sun H, Koeffler HP, Melnick A, Paietta E, Glimcher LH, Muschen M. The Plasma Cell Transcription Factor XBP1 is Required To Mitigate The Unfolded Protein Response In Ph+ ALL Blood. 122: 836-836. DOI: 10.1182/Blood.V122.21.836.836  0.3
2013 Hatzi K, Maria Nieves C, Cerchietti L, Melnick AM. The Histone Demethylase LSD1 Acts As a BCL6 Corepressor In Germinal Center B Cells Blood. 122: 781-781. DOI: 10.1182/blood.v122.21.781.781  0.36
2013 Hurtz C, Geng H, Ballabio E, Xiao G, Ng C, Masouleh BK, Willman CL, Armstrong SA, Milne T, Melnick A, Muschen M. Identification Of BCL6 As a Therapeutic Target In MLL-Rearranged ALL Blood. 122: 72-72. DOI: 10.1182/Blood.V122.21.72.72  0.32
2013 Shih AH, Jiang Y, Shank K, Pandey S, Viale A, Sun Y, Socci N, Robertson A, de Stanchina E, Hricik T, Rapaport F, Woods B, Cimmino L, Barreyro L, Steidl U, ... ... Melnick A, et al. Epigenetic Profiling Of Leukemia Stem Cells In a Model Of TET2/FLT3-Mutant AML Blood. 122: 476-476. DOI: 10.1182/Blood.V122.21.476.476  0.31
2013 Geng H, Hurtz C, Chen Z, Chen W, Ballabio E, Xiao G, Kweon S, Nahar R, Sojaee S, Chan LN, Masouleh BK, Sykes DB, Melnick A, Roeder R, Milne T, et al. Targeting Pre-B Cell Receptor and BCL6 In TCF3-PBX1 B-Lineage Acute Lymphoblastic Leukemia Blood. 122: 349-349. DOI: 10.1182/Blood.V122.21.349.349  0.318
2013 Teater MR, Hatzi K, Popovich R, Jiang Y, Bunting KL, Rosen M, Shen H, Yang SN, Chung YR, Shaknovich R, Creasy C, Gascoyne RD, Cerchietti L, Levine RL, Abdel-Wahab O, ... Melnick AM, et al. EZH2 and BCL6 Cooperate To Create The Germinal Center B-Cell Phenotype and Induce Lymphomas Through Formation and Repression Of Bivalent Chromatin Domains Blood. 122: 1-1. DOI: 10.1182/Blood.V122.21.1.1  0.361
2012 Cubedo E, Gentles AJ, Huang C, Natkunam Y, Bhatt S, Lu X, Jiang X, Romero-Camarero I, Freud A, Zhao S, Bacchi CE, Martínez-Climent JA, Sánchez-García I, Melnick A, Lossos IS. Identification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma. Blood. 119: 5478-91. PMID 22517897 DOI: 10.1182/Blood-2012-01-403154  0.326
2012 Hurtz C, Ramezani-Rad P, Geng H, Kharabi B, Carroll WL, Willman CL, Armstrong SA, Melnick A, Muschen M. Targeting BCL6-Mediated Drug-Resistance in High-Risk Childhood ALL Blood. 120: 776-776. DOI: 10.1182/Blood.V120.21.776.776  0.302
2012 Pandolfi A, Bartholdy B, Kawahara M, Barreyro L, Will B, Stanley R, Michael R, Okoye-Okafor UC, Todorova TI, Figueroa ME, Melnick A, Mitsiades CS, Steidl U. H2.0-Like Homeobox (HLX) Induces Unlimited Clonogenicity, Blocks Differentiation, and Cooperates with FLT3-ITD in the Induction of Acute Myeloid Leukemia Blood. 120: 651-651. DOI: 10.1182/Blood.V120.21.651.651  0.327
2012 Jiang Y, Hatzi K, Elemento O, Melnick A. Enhancer Profiling Reveals SOX9 As a Novel Transcription Regulator of B Cell Activation and DLBCL Transformation Blood. 120: 527-527. DOI: 10.1182/Blood.V120.21.527.527  0.356
2012 Bunting KL, Soong D, Jiang Y, Swed BL, Hatzi K, Shaknovich R, Reisacher W, Elemento O, Melnick A. Three-Dimensional Reorganization of the Genome During B Cell Affinity Maturation Blood. 120: 279-279. DOI: 10.1182/Blood.V120.21.279.279  0.317
2012 Swaminathan S, Kang H, Harvey RC, Huang C, Buchner M, Chen Z, Geng H, Hall A, Igarashi K, Carroll WL, Willman CL, Melnick A, Muschen M. BACH2 Is Required for Pre-B Cell Receptor Checkpoint Control and p53-Dependent Tumor Surveillance Blood. 120: 1300-1300. DOI: 10.1182/Blood.V120.21.1300.1300  0.305
2011 Shaknovich R, Melnick A. Epigenetics and B-cell lymphoma Current Opinion in Hematology. 18: 293-299. PMID 21577103 DOI: 10.1097/Moh.0B013E32834788Cf  0.31
2011 Swaminathan S, Huang C, Titz B, Buchner M, Geng H, Graeber TG, Willman CL, Igarashi K, Melnick A, Muschen M. BACH2 Mediates Early B Cell Differentiation and Oncogene-Induced Senescence in Acute Lymphoblastic Leukemia Blood. 118: 562-562. DOI: 10.1182/Blood.V118.21.562.562  0.317
2011 Bunting KL, Soong TD, Chatzi K, Jiang Y, Elemento O, Melnick A. A Role for BCL6 in the Higher-Order Organization of Genes in DLBCL Blood. 118: 558-558. DOI: 10.1182/Blood.V118.21.558.558  0.323
2011 Cubedo E, Gentles AJ, Huang C, Natkunam Y, Bhatt S, Jiang X, Lu X, Romero-Camarero I, Plevritis SK, Martinez-Climent JA, Sanchez-Garcia I, Melnick A, Lossos IS. Identification of LMO2 Transcriptome and Interactome in Diffuse Large B-Cell Lymphoma by Integrated Experimental and Computational Approach Blood. 118: 438-438. DOI: 10.1182/Blood.V118.21.438.438  0.315
2011 Abdel-Wahab O, Adli M, Saunders L, Gao J, Shih AH, Pandey S, Jaffe J, Zhao X, Perna F, Carroll M, Melnick A, Nimer SD, Aifantis I, Bernstein B, Levine RL. ASXL1 Mutations Promote Myeloid Transformation Through Inhibition of PRC2-Mediated Gene Repression Blood. 118: 405-405. DOI: 10.1182/Blood.V118.21.405.405  0.301
2011 Jiang Y, Soong D, Huang C, Monni S, Melnick A, Elemento O. Genomewide Detection of Genes Targeted by Aberrant Somatic Hypermutation in Lymphoma Blood. 118: 3474-3474. DOI: 10.1182/Blood.V118.21.3474.3474  0.363
2011 Clozel T, Yang S, Kormaksson M, Elstrom R, Vasanthakumar A, Brennan S, Culjkovic B, Leser M, Martin P, Borden KL, Wang YL, Cheng S, Tam W, Shaknovich R, Chadburn A, ... ... Melnick A, et al. Chemosensitization of Diffuse Large B Cell Lymphoma by Demethylating Nucleoside Analogues Blood. 118: 1617-1617. DOI: 10.1182/Blood.V118.21.1617.1617  0.313
2011 Bertolo C, Malumbres R, Sagardoy A, Robles EF, Martinez-Ferrandis JI, Roa S, Lossos IS, Sagaert X, Melnick A, Amar S, Martinez-Climent JA. LITAF, a BCL6 Target Gene, Regulates Autophagia in B Cells and Is Essential for T-Cell Dependent Humoral Responses Blood. 118: 1391-1391. DOI: 10.1182/Blood.V118.21.1391.1391  0.304
2010 Cerchietti LC, Hatzi K, Caldas-Lopes E, Yang SN, Figueroa ME, Morin RD, Hirst M, Mendez L, Shaknovich R, Cole PA, Bhalla K, Gascoyne RD, Marra M, Chiosis G, Melnick A. BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy. The Journal of Clinical Investigation. 120: 4569-82. PMID 21041953 DOI: 10.1172/Jci42869  0.312
2010 Velichutina I, Shaknovich R, Geng H, Johnson NA, Gascoyne RD, Melnick AM, Elemento O. EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis. Blood. 116: 5247-55. PMID 20736451 DOI: 10.1182/blood-2010-04-280149  0.345
2010 Shaknovich R, Geng H, Johnson NA, Tsikitas L, Cerchietti L, Greally JM, Gascoyne RD, Elemento O, Melnick A. DNA methylation signatures define molecular subtypes of diffuse large B-cell lymphoma. Blood. 116: e81-9. PMID 20610814 DOI: 10.1182/Blood-2010-05-285320  0.312
2010 Matthews JM, Natkunam Y, Srinivasan S, Patricelli M, Nomanbhoy T, Cerchietti L, Melnick AM, Lossos IS. STAT3, Constitutively Activated In ABC-Like DLBCL, Regulates Expression of the Prognostic Factor Cyclin D2 Blood. 116: 705-705. DOI: 10.1182/Blood.V116.21.705.705  0.305
2010 Hurtz C, Duy C, Cerchietti L, Chatzi K, Park E, Klemm L, Kim Y, Kahn M, Braig M, Muller MC, Hochhaus A, Ye BH, Melnick AM, Muschen M. BCL6 Is Required for the Maintenance of Leukemia-Initiating Cells In Chronic Myeloid Leukemia Blood. 116: 202-202. DOI: 10.1182/Blood.V116.21.202.202  0.324
2010 Taylor KH, Shaknovich R, Martin-Subero J, Arthur G, Bennett L, Ammerpohl O, Richter J, Siebert R, Melnick A, Caldwell C. Abstract 168: Genome-wide survey of CpG methylation across the spectrum of B-cell lymphomas Cancer Research. 70: 168-168. DOI: 10.1158/1538-7445.Am10-168  0.309
2009 Juszczynski P, Chen L, O'Donnell E, Polo JM, Ranuncolo SM, Dalla-Favera R, Melnick A, Shipp MA. BCL6 modulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt. Blood. 114: 5315-21. PMID 19855081 DOI: 10.1182/Blood-2009-02-204362  0.317
2009 Ci W, Polo JM, Cerchietti L, Shaknovich R, Wang L, Yang SN, Ye K, Farinha P, Horsman DE, Gascoyne RD, Elemento O, Melnick A. The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL. Blood. 113: 5536-48. PMID 19307668 DOI: 10.1182/Blood-2008-12-193037  0.34
2009 Leshchenko V, Kuo P, Shaknovich R, Gellen T, Remache Y, Weniger M, Suh KS, Goy A, Wilson W, Braunschweig I, Verma A, Wiestner A, Melnick A, Parekh S. Genome-Wide Methylation Analysis of Primary Mantle Cell Lymphomas Identifies Novel Gene Targets for Epigenetic Drug Therapy. Blood. 114: 673-673. DOI: 10.1182/Blood.V114.22.673.673  0.318
2009 Velichutina I, Shaknovich R, Geng H, Melnick A, Elemento O. EZH2 Mediates DNA Methylation-Independent Epigenetic Silencing of a Germinal Center Specific Transcriptional Program That Contributes to Cellular Proliferation and Lymphomagenesis. Blood. 114: 3465-3465. DOI: 10.1182/Blood.V114.22.3465.3465  0.34
2009 Hurtz C, Duy C, Cerchietti L, Park E, Ci W, Swaminathan S, Kweon S, Klemm L, Kim Y, Martinelli G, Hofmann W, Ye BH, Melnick A, Müschen M. BCL6 Is Required for Leukemia-Initiation and Self-Renewal Signaling in Chronic Myeloid Leukemia. Blood. 114: 2167-2167. DOI: 10.1182/Blood.V114.22.2167.2167  0.301
2008 Ci W, Polo JM, Melnick A. B-cell lymphoma 6 and the molecular pathogenesis of diffuse large B-cell lymphoma. Current Opinion in Hematology. 15: 381-390. PMID 18536578 DOI: 10.1097/Moh.0B013E328302C7Df  0.33
2008 Ranuncolo SM, Wang L, Polo JM, Dell'Oso T, Dierov J, Gaymes TJ, Rassool F, Carroll M, Melnick A. BCL6-mediated attenuation of DNA damage sensing triggers growth arrest and senescence through a p53-dependent pathway in a cell context-dependent manner Journal of Biological Chemistry. 283: 22565-22572. PMID 18524763 DOI: 10.1074/Jbc.M803490200  0.315
2008 Parekh S, Prive G, Melnick A. Therapeutic targeting of the BCL6 oncogene for diffuse large B-cell lymphomas Leukemia and Lymphoma. 49: 874-882. PMID 18452090 DOI: 10.1080/10428190801895345  0.322
2008 Ranuncolo SM, Polo JM, Melnick A. BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells. Blood Cells Molecules and Diseases. 41: 95-99. PMID 18346918 DOI: 10.1016/J.Bcmd.2008.02.003  0.314
2008 Mendez LM, Polo JM, Yu JJ, Krupski M, Ding BB, Melnick A, Ye BH. CtBP is an essential corepressor for BCL6 autoregulation. Molecular and Cellular Biology. 28: 2175-86. PMID 18212045 DOI: 10.1128/Mcb.01400-07  0.322
2008 Gellen T, Kuo P, Shaknovich R, Figueroa ME, Melnick A, Wiestner A, Parekh S. Epigenetic Determinants of Pathogenesis and Resistance to Proteosome Inhibition in Mantle Cell Lymphoma. Blood. 112: 3373-3373. DOI: 10.1182/Blood.V112.11.3373.3373  0.32
2007 Ranuncolo SM, Polo JM, Dierov J, Singer M, Kuo T, Greally J, Green R, Carroll M, Melnick A. Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR. Nature Immunology. 8: 705-14. PMID 17558410 DOI: 10.1038/Ni1478  0.305
2007 Parekh S, Polo JM, Shaknovich R, Juszczynski P, Lev P, Ranuncolo SM, Yin Y, Klein U, Cattoretti G, Dalla Favera R, Shipp MA, Melnick A. BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms. Blood. 110: 2067-74. PMID 17545502 DOI: 10.1182/Blood-2007-01-069575  0.317
2007 Polo JM, Juszczynski P, Monti S, Cerchietti L, Ye K, Greally JM, Shipp M, Melnick A. Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas. Proceedings of the National Academy of Sciences of the United States of America. 104: 3207-12. PMID 17360630 DOI: 10.1073/Pnas.0611399104  0.316
2007 Shaknovich R, Cerchietti L, Figueroa ME, Melnick A. DNA Methyltransferase 1 Contributes to Epigenetic Signatures and Biological Phenotype during Normal B-Cell Differentiation and Lymphomagenesis. Blood. 110: 685-685. DOI: 10.1182/Blood.V110.11.685.685  0.331
2007 Ci W, Polo JM, Ranuncolo SM, Melnick A. A “Survival of the Fittest” Mechanism for Weeding Out Potentially Lymphomagenic B-Cells during Germinal Center B-Cell Differentiation. Blood. 110: 559-559. DOI: 10.1182/Blood.V110.11.559.559  0.325
2007 Mendez LM, Polo J, Krupski M, Yu J, Melnick AM, Ye B. CtBP1 Is a Novel and Essential Corepressor for BCL6 Autoregulation. Blood. 110: 3581-3581. DOI: 10.1182/BLOOD.V110.11.3581.3581  0.349
2007 Perez-Caro M, Cobaleda C, Piris MA, Melnick AM, Snachez-Garcia I. The BCL6 Oncogene Drives an Epigenomic Program Linking Stem Cells to the Pathogenesis of Human Diffuse Large B Cell Lymphoma in Mice. Blood. 110: 3372-3372. DOI: 10.1182/BLOOD.V110.11.3372.3372  0.322
2007 Velichutina I, Melnick A. Regulation of Hox Genes by Polycomb Group Protein EZH2 Plays a Critical Role in Diffuse Large B-Cell Lymphoma Cells. Blood. 110: 1562-1562. DOI: 10.1182/Blood.V110.11.1562.1562  0.342
2006 Polo JM, Juszczynski P, Cerchietti L, Monti S, Ye K, Shipp MA, Melnick AM. A BCL6 Target Gene Signature Predicts the Biological Behavior and Classification of Diffuse Large B-Cell Lymphoma. Blood. 108: 616-616. DOI: 10.1182/Blood.V108.11.616.616  0.326
2006 Parekh S, Polo J, Juszczynski P, Lev P, Ranuncolo S, Cattoretti G, Shaknovich R, Shipp M, Melnick A. BCL6 Programs Lymphoma Cells for Survival and Differentiation through Distinct Biochemical Mechanisms, Both of Which Can Be Therapeutically Targeted. Blood. 108: 225-225. DOI: 10.1182/Blood.V108.11.225.225  0.319
2005 Melnick A. Reprogramming specific gene expression pathways in B-cell lymphomas. Cell Cycle. 4: 239-241. DOI: 10.4161/Cc.4.2.1469  0.332
2005 Polo JM, Ranuncolo SM, Parek S, Arcaya J, Melnick AM. The BCL6 Oncoprotein Forms Distinct Transcriptional Repression Complexes on Cohorts of Target Genes Involved in Specific Cellular Functions. Blood. 106: 2615-2615. DOI: 10.1182/BLOOD.V106.11.2615.2615  0.327
2005 Ranuncolo SM, Polo JM, Dierov J, Shaknovich R, Carroll M, Melnick AM. BCL6 Attenuates DNA Damage Sensing in Normal and Malignant B-Cells by Directly Repressing ATR. Blood. 106: 157-157. DOI: 10.1182/BLOOD.V106.11.157.157  0.302
2004 Chevallier N, Corcoran CM, Lennon C, Hyjek E, Chadburn A, Bardwell VJ, Licht JD, Melnick A. ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein. Blood. 103: 1454-63. PMID 14551142 DOI: 10.1182/Blood-2003-06-2081  0.324
2004 Polo JM, Dell’Oso T, Ranuncolo SM, Cerchietti L, Silva GFD, Prive GG, Licht JD, Melnick A. Specific Peptide Disruption of the Bcl-6 Repression Complex Reveals Its Transcriptional Mechanism of Action in Normal and Malignant B-Cells and Is a Novel Therapeutic Approach for Diffuse Large B-Cell Lymphoma. Blood. 104: 5-5. DOI: 10.1182/Blood.V104.11.5.5  0.348
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