| Year |
Citation |
Score |
| 2022 |
Bideyan L, López Rodríguez M, Priest C, Kennelly JP, Gao Y, Ferrari A, Rajbhandari P, Feng AC, Tevosian SG, Smale ST, Tontonoz P. Hepatic GATA4 regulates cholesterol and triglyceride homeostasis in collaboration with LXRs. Genes & Development. PMID 36522129 DOI: 10.1101/gad.350145.122 |
0.384 |
|
| 2022 |
Qian K, Tol MJ, Wu J, Uchiyama LF, Xiao X, Cui L, Bedard AH, Weston TA, Rajendran PS, Vergnes L, Shimanaka Y, Yin Y, Jami-Alahmadi Y, Cohn W, Bajar BT, ... ... Tontonoz P, et al. CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization. Nature. PMID 36477540 DOI: 10.1038/s41586-022-05507-1 |
0.336 |
|
| 2022 |
Bideyan L, Fan W, Kaczor-Urbanowicz KE, Priest C, Casero D, Tontonoz P. Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35145035 DOI: 10.1073/pnas.2122683119 |
0.393 |
|
| 2021 |
Guo F, Seldin M, Péterfy M, Charugundla S, Zhou Z, Lee SD, Mouton A, Rajbhandari P, Zhang W, Pellegrini M, Tontonoz P, Lusis AJ, Shih DM. NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice. Scientific Reports. 11: 16409. PMID 34385484 DOI: 10.1038/s41598-021-95720-1 |
0.329 |
|
| 2020 |
Zhou Z, Moore TM, Drew BG, Ribas V, Wanagat J, Civelek M, Segawa M, Wolf DM, Norheim F, Seldin MM, Strumwasser AR, Whitney KA, Lester E, Reddish BR, Vergnes L, ... ... Tontonoz P, et al. Estrogen receptor α controls metabolism in white and brown adipocytes by regulating and mitochondrial remodeling. Science Translational Medicine. 12. PMID 32759275 DOI: 10.1126/Scitranslmed.Aax8096 |
0.419 |
|
| 2020 |
Ferrari A, He C, Kennelly JP, Sandhu J, Xiao X, Chi X, Jiang H, Young SG, Tontonoz P. Aster proteins regulate the accessible cholesterol pool in the plasma membrane. Molecular and Cellular Biology. PMID 32719109 DOI: 10.1128/Mcb.00255-20 |
0.42 |
|
| 2020 |
Zhou QD, Chi X, Lee MS, Hsieh WY, Mkrtchyan JJ, Feng AC, He C, York AG, Bui VL, Kronenberger EB, Ferrari A, Xiao X, Daly AE, Tarling EJ, Damoiseaux R, ... ... Tontonoz P, et al. Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins. Nature Immunology. PMID 32514064 DOI: 10.1038/S41590-020-0695-4 |
0.406 |
|
| 2020 |
Ichu TA, Reed A, Ogasawara D, Ulanovskaya O, Roberts A, Aguirre CA, Bar-Peled L, Gao J, Germain J, Barbas S, Masuda K, Conti B, Tontonoz P, Cravatt BF. ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease. Biochemistry. PMID 32364701 DOI: 10.1021/Acs.Biochem.0C00292 |
0.351 |
|
| 2020 |
He C, Jiang H, Song W, Riezman H, Tontonoz P, Weston TA, Guagliardo P, Kim PH, Jung R, Heizer P, Fong LG, Young SG. Cultured macrophages transfer surplus cholesterol into adjacent cells in the absence of serum or high-density lipoproteins. Proceedings of the National Academy of Sciences of the United States of America. PMID 32354992 DOI: 10.1073/Pnas.1922879117 |
0.395 |
|
| 2020 |
Wang X, Cai B, Yang X, Sonubi OO, Zheng Z, Ramakrishnan R, Shi H, Valenti L, Pajvani UB, Sandhu J, Infante RE, Radhakrishnan A, Covey DF, Guan KL, Buck J, ... ... Tontonoz P, et al. Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis. Cell Metabolism. PMID 32259482 DOI: 10.1016/J.Cmet.2020.03.010 |
0.427 |
|
| 2020 |
Gao J, Littman R, Diamante G, Xiao X, Ahn IS, Yang X, Cole TA, Tontonoz P. Therapeutic IDOL reduction ameliorates amyloidosis and improves cognitive function in APP/PS1 mice. Molecular and Cellular Biology. PMID 31964754 DOI: 10.1128/Mcb.00518-19 |
0.395 |
|
| 2020 |
Wang X, Radhakrishnan A, Covey D, Horton J, Schwabe R, Tontonoz P, Guan K, Tabas I. Abstract B04: Hepatic cholesterol upregulates TAZ in nonalcoholic steatohepatitis Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Hippo19-B04 |
0.426 |
|
| 2019 |
Lee SD, Priest C, Bjursell M, Gao J, Arneson DV, Ahn IS, Diamante G, van Veen JE, Massa MG, Calkin AC, Kim J, Andersén H, Rajbhandari P, Porritt M, Carreras A, ... ... Tontonoz P, et al. IDOL regulates systemic energy balance through control of neuronal VLDLR expression. Nature Metabolism. 1: 1089-1100. PMID 32072135 DOI: 10.1038/s42255-019-0127-7 |
0.655 |
|
| 2019 |
Choudhary M, Ismail EN, Yao PL, Tayyari F, Radu RA, Nusinowitz S, Boulton ME, Apte RS, Ruberti JW, Handa JT, Tontonoz P, Malek G. LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target. Jci Insight. PMID 31829999 DOI: 10.1172/Jci.Insight.131928 |
0.414 |
|
| 2019 |
Rajbhandari P, Arneson D, Hart SK, Ahn IS, Diamante G, Santos LC, Zaghari N, Feng AC, Thomas BJ, Vergnes L, Lee SD, Rajbhandari AK, Reue K, Smale ST, Yang X, ... Tontonoz P, et al. Single cell analysis reveals immune cell-adipocyte crosstalk regulating the transcription of thermogenic adipocytes. Elife. 8. PMID 31644425 DOI: 10.7554/Elife.49501 |
0.38 |
|
| 2019 |
Hu X, Weston TA, He C, Jung RS, Heizer PJ, Young BD, Tu Y, Tontonoz P, Wohlschlegel JA, Jiang H, Young SG, Fong LG. Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia. Elife. 8. PMID 31486771 DOI: 10.7554/Elife.50231 |
0.311 |
|
| 2019 |
Pearson S, Loft A, Rahbhandari P, Simcox J, Lee S, Tontonoz P, Mandrup S, Villanueva CJ. Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism. Genes & Development. PMID 31123067 DOI: 10.1101/Gad.321059.118 |
0.408 |
|
| 2019 |
Blázquez-Medela AM, Jumabay M, Rajbhandari P, Sallam T, Guo Y, Yao J, Vergnes L, Reue K, Zhang L, Yao Y, Fogelman AM, Tontonoz P, Lusis AJ, Wu X, Boström KI. Noggin depletion in adipocytes promotes obesity in mice. Molecular Metabolism. PMID 31027994 DOI: 10.1016/J.Molmet.2019.04.004 |
0.337 |
|
| 2019 |
Shih DM, Meng Y, Sallam T, Vergnes L, Shu ML, Reue K, Tontonoz P, Fogelman AM, Lusis AJ, Reddy ST. PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity. Antioxidants (Basel, Switzerland). 8. PMID 30641857 DOI: 10.3390/Antiox8010019 |
0.363 |
|
| 2019 |
Ramón-Vázquez A, de la Rosa JV, Tabraue C, Lopez F, Díaz-Chico BN, Bosca L, Tontonoz P, Alemany S, Castrillo A. Common and Differential Transcriptional Actions of Nuclear Receptors LXRα and LXRβ in macrophages. Molecular and Cellular Biology. PMID 30602495 DOI: 10.1128/Mcb.00376-18 |
0.518 |
|
| 2019 |
Rajbhandari P, Arneson D, Hart SK, Ahn IS, Diamante G, Santos LC, Zaghari N, Feng A, Thomas BJ, Vergnes L, Lee SD, Rajbhandari AK, Reue K, Smale ST, Yang X, ... Tontonoz P, et al. Author response: Single cell analysis reveals immune cell–adipocyte crosstalk regulating the transcription of thermogenic adipocytes Elife. DOI: 10.7554/Elife.49501.021 |
0.35 |
|
| 2018 |
Zhang P, Csaki LS, Ronquillo E, Baufeld LJ, Lin JY, Gutierrez A, Dwyer JR, Brindley DN, Fong LG, Tontonoz P, Young SG, Reue K. Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis. The Journal of Clinical Investigation. PMID 30507612 DOI: 10.1172/Jci122595 |
0.379 |
|
| 2018 |
Wang B, Tontonoz P. Phospholipid Remodeling in Physiology and Disease. Annual Review of Physiology. PMID 30379616 DOI: 10.1146/Annurev-Physiol-020518-114444 |
0.382 |
|
| 2018 |
He C, Hu X, Weston TA, Jung RS, Heizer P, Tu Y, Ellison R, Matsumoto K, Gerhardt H, Tontonoz P, Fong LG, Young SG, Jiang H. NanoSIMS imaging reveals unexpected heterogeneity in nutrient uptake by brown adipocytes. Biochemical and Biophysical Research Communications. PMID 30224066 DOI: 10.1016/J.Bbrc.2018.09.051 |
0.358 |
|
| 2018 |
Sandhu J, Li S, Fairall L, Pfisterer SG, Gurnett JE, Xiao X, Weston TA, Vashi D, Ferrari A, Orozco JL, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, ... ... Tontonoz P, et al. Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells. Cell. PMID 30220461 DOI: 10.1016/J.Cell.2018.08.033 |
0.587 |
|
| 2018 |
He C, Hu X, Weston TA, Jung RS, Sandhu J, Huang S, Heizer P, Kim J, Ellison R, Xu J, Kilburn M, Bensinger SJ, Riezman H, Tontonoz P, Fong LG, et al. Macrophages release plasma membrane-derived particles rich in accessible cholesterol. Proceedings of the National Academy of Sciences of the United States of America. PMID 30127022 DOI: 10.1073/Pnas.1810724115 |
0.333 |
|
| 2018 |
Wang B, Tontonoz P. Liver X receptors in lipid signalling and membrane homeostasis. Nature Reviews. Endocrinology. PMID 29904174 DOI: 10.1038/S41574-018-0037-X |
0.515 |
|
| 2018 |
Cheng Y, Yuan Q, Vergnes L, Rong X, Youn JY, Li J, Yu Y, Liu W, Cai H, Lin JD, Tontonoz P, Hong C, Reue K, Wang CY. KDM4B protects against obesity and metabolic dysfunction. Proceedings of the National Academy of Sciences of the United States of America. PMID 29844188 DOI: 10.1073/Pnas.1721814115 |
0.65 |
|
| 2018 |
Seldin MM, Koplev S, Rajbhandari P, Vergnes L, Rosenberg GM, Meng Y, Pan C, Phuong TMN, Gharakhanian R, Che N, Mäkinen S, Shih DM, Civelek M, Parks BW, Kim ED, ... ... Tontonoz P, et al. A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism. Cell Metabolism. 27: 1138-1155.e6. PMID 29719227 DOI: 10.1016/J.Cmet.2018.03.015 |
0.328 |
|
| 2018 |
He C, Weston TA, Jung RS, Heizer P, Larsson M, Hu X, Allan CM, Tontonoz P, Reue K, Beigneux AP, Ploug M, Holme A, Kilburn M, Guagliardo P, Ford DA, et al. NanoSIMS Analysis of Intravascular Lipolysis and Lipid Movement across Capillaries and into Cardiomyocytes. Cell Metabolism. 27: 1055-1066.e3. PMID 29719224 DOI: 10.1016/J.Cmet.2018.03.017 |
0.361 |
|
| 2018 |
Beceiro S, Pap A, Czimmerer Z, Sallam T, Guillén JA, Gallardo G, Hong C, A-Gonzalez N, Tabraue C, Diaz M, Lopez F, Matalonga J, Valledor AF, Dominguez P, Ardavin C, ... ... Tontonoz P, et al. LXR nuclear receptors are transcriptional regulators of dendritic cell chemotaxis. Molecular and Cellular Biology. PMID 29507185 DOI: 10.1128/Mcb.00534-17 |
0.657 |
|
| 2018 |
Sallam T, Jones M, Thomas BJ, Wu X, Gilliland T, Qian K, Eskin A, Casero D, Zhang Z, Sandhu J, Salisbury D, Rajbhandari P, Civelek M, Hong C, Ito A, ... ... Tontonoz P, et al. Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA. Nature Medicine. PMID 29431742 DOI: 10.1038/Nm.4479 |
0.709 |
|
| 2018 |
Wang B, Rong X, Palladino END, Wang J, Fogelman AM, Martín MG, Alrefai WA, Ford DA, Tontonoz P. Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis. Cell Stem Cell. 22: 206-220.e4. PMID 29395055 DOI: 10.1016/J.Stem.2017.12.017 |
0.427 |
|
| 2018 |
Zhou Z, Ribas V, Rajbhandari P, Drew BG, Moore TM, Fluitt AH, Reddish BR, Whitney KA, Georgia S, Vergnes L, Reue K, Liesa M, Shirihai O, van der Bliek AM, Chi NW, ... ... Tontonoz P, et al. Estrogen receptor alpha protects pancreatic beta cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress. The Journal of Biological Chemistry. PMID 29378845 DOI: 10.1074/Jbc.M117.805069 |
0.364 |
|
| 2018 |
Rajbhandari P, Thomas BJ, Feng AC, Hong C, Wang J, Vergnes L, Sallam T, Wang B, Sandhu J, Seldin MM, Lusis AJ, Fong LG, Katz M, Lee R, Young SG, ... ... Tontonoz P, et al. IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure. Cell. 172: 218-233.e17. PMID 29249357 DOI: 10.1016/J.Cell.2017.11.019 |
0.603 |
|
| 2017 |
Bornfeldt KE, Kramer F, Batorsky A, Choi J, Hudkins KL, Tontonoz P, Alpers CE, Kanter JE. A Novel Type 2 Diabetes Mouse Model of Combined Diabetic Kidney Disease and Atherosclerosis. The American Journal of Pathology. PMID 29154962 DOI: 10.1016/J.Ajpath.2017.10.012 |
0.329 |
|
| 2017 |
Zhang L, Rajbhandari P, Priest C, Sandhu J, Wu X, Temel R, Castrillo A, de Aguiar Vallim TQ, Sallam T, Tontonoz P. Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP. Elife. 6. PMID 29068315 DOI: 10.7554/Elife.28766 |
0.455 |
|
| 2017 |
Rong X, Wang B, Palladino EN, de Aguiar Vallim TQ, Ford DA, Tontonoz P. ER phospholipid composition modulates lipogenesis during feeding and in obesity. The Journal of Clinical Investigation. PMID 28846071 DOI: 10.1172/Jci93616 |
0.408 |
|
| 2017 |
Yao J, Guihard PJ, Wu X, Blazquez-Medela AM, Spencer MJ, Jumabay M, Tontonoz P, Fogelman AM, Boström KI, Yao Y. Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation. The Journal of Cell Biology. PMID 28838957 DOI: 10.1083/Jcb.201612122 |
0.309 |
|
| 2017 |
Tontonoz P, Wu X, Jones M, Zhang Z, Salisbury D, Sallam T. Long Noncoding RNA Facilitated Gene Therapy Reduces Atherosclerosis in a Murine Model of Familial Hypercholesterolemia. Circulation. 136: 776-778. PMID 28827223 DOI: 10.1161/Circulationaha.117.029002 |
0.428 |
|
| 2017 |
Mukherjee P, Hough G, Chattopadhyay A, Navab M, Fogelman HR, Meriwether D, Williams K, Bensinger S, Moller T, Faull KF, Lusis AJ, Iruela-Arispe L, Bostrom KI, Tontonoz P, Reddy ST, et al. Transgenic Tomatoes Expressing the 6F Peptide and Ezetimibe Prevent Diet-induced Increases of Interferon-β and Cholesterol 25-hydroxylase in Jejunum. Journal of Lipid Research. PMID 28592401 DOI: 10.1194/Jlr.M076554 |
0.31 |
|
| 2017 |
Wang J, Tontonoz P. Pioneering EBF2 remodels the brown fat chromatin landscape. Genes & Development. 31: 632-633. PMID 28446594 DOI: 10.1101/Gad.299644.117 |
0.414 |
|
| 2017 |
Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, ... ... Tontonoz P, et al. Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia. The New England Journal of Medicine. PMID 28402248 DOI: 10.1056/Nejmoa1611930 |
0.303 |
|
| 2017 |
Wang J, Rajbhandari P, Damianov A, Han A, Sallam T, Waki H, Villanueva CJ, Lee SD, Nielsen R, Mandrup S, Reue K, Young SG, Whitelegge J, Saez E, Black DL, ... Tontonoz P, et al. RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs. The Journal of Clinical Investigation. PMID 28192372 DOI: 10.1172/Jci89484 |
0.651 |
|
| 2017 |
Zhang L, Rajbhandari P, Priest C, Sandhu J, Wu X, Temel R, Castrillo A, Vallim TQdA, Sallam T, Tontonoz P. Author response: Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP Elife. DOI: 10.7554/Elife.28766.018 |
0.335 |
|
| 2016 |
Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum JL, Diaz M, Castrillo A, Bensinger SJ, Chan L, Tontonoz P. Cholesterol Accumulation in CD11c(+) Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease. Immunity. 45: 1311-1326. PMID 28002731 DOI: 10.1016/J.Immuni.2016.11.008 |
0.663 |
|
| 2016 |
Kim DH, Kim J, Kwon JS, Sandhu J, Tontonoz P, Lee SK, Lee S, Lee JW. Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARγ2. Cell Reports. 17: 1671-1682. PMID 27806304 DOI: 10.1016/J.Celrep.2016.10.023 |
0.393 |
|
| 2016 |
Villa GR, Hulce JJ, Zanca C, Bi J, Ikegami S, Cahill GL, Gu Y, Lum KM, Masui K, Yang H, Rong X, Hong C, Turner KM, Liu F, Hon GC, ... ... Tontonoz P, et al. An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers. Cancer Cell. PMID 27746144 DOI: 10.1016/J.Ccell.2016.09.008 |
0.597 |
|
| 2016 |
Song NJ, Kim S, Jang BH, Chang SH, Yun UJ, Park KM, Waki H, Li DY, Tontonoz P, Park KW. Small Molecule-Induced Complement Factor D (Adipsin) Promotes Lipid Accumulation and Adipocyte Differentiation. Plos One. 11: e0162228. PMID 27611793 DOI: 10.1371/Journal.Pone.0162228 |
0.485 |
|
| 2016 |
Lee SD, Tontonoz P. sLRP1ng Up Glucose: LRP1 Regulates Hepatic Insulin Responses. Ebiomedicine. 7: 17-18. PMID 27322451 DOI: 10.1016/J.Ebiom.2016.05.018 |
0.418 |
|
| 2016 |
Sallam T, Jones MC, Gilliland T, Zhang L, Wu X, Eskin A, Sandhu J, Casero D, Vallim TQ, Hong C, Katz M, Lee R, Whitelegge J, Tontonoz P. Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis. Nature. 534: 124-8. PMID 27251289 DOI: 10.1038/Nature17674 |
0.683 |
|
| 2016 |
Song NJ, Choi S, Rajbhandari P, Chang SH, Kim S, Vergnes L, Kwon SM, Yoon JH, Lee S, Ku JM, Lee JS, Reue K, Koo SH, Tontonoz P, Park KW. Prdm4 induction by the small molecule butein promotes white adipose tissue browning. Nature Chemical Biology. PMID 27159578 DOI: 10.1038/Nchembio.2081 |
0.372 |
|
| 2016 |
Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, ... ... Tontonoz P, et al. Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Science Translational Medicine. 8: 334ra54. PMID 27075628 DOI: 10.1126/Scitranslmed.Aad3815 |
0.361 |
|
| 2016 |
Allan CM, Procaccia S, Tran D, Tu Y, Barnes RH, Larsson M, Allan BB, Young LC, Hong C, Tontonoz P, Fong LG, Young SG, Beigneux AP. Palmoplantar Keratoderma in Slurp2-Deficient Mice. The Journal of Investigative Dermatology. 136: 436-443. PMID 26967477 DOI: 10.1016/J.Jid.2015.11.003 |
0.582 |
|
| 2016 |
Wang B, Rong X, Duerr MA, Hermanson DJ, Hedde PN, Wong JS, de Aguiar Vallim TQ, Cravatt BF, Gratton E, Ford DA, Tontonoz P. Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet. Cell Metabolism. PMID 26833026 DOI: 10.1016/J.Cmet.2016.01.001 |
0.346 |
|
| 2015 |
Choi J, Gao J, Kim J, Hong C, Kim J, Tontonoz P. The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aβ amyloidosis. Science Translational Medicine. 7: 314ra184. PMID 26582899 DOI: 10.1126/Scitranslmed.Aad1904 |
0.593 |
|
| 2015 |
Briot A, Civelek M, Seki A, Hoi K, Mack JJ, Lee SD, Kim J, Hong C, Yu J, Fishbein GA, Vakili L, Fogelman AM, Fishbein MC, Lusis AJ, Tontonoz P, et al. Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis. The Journal of Experimental Medicine. PMID 26552708 DOI: 10.1084/Jem.20150603 |
0.64 |
|
| 2015 |
Ito A, Hong C, Rong X, Zhu X, Tarling EJ, Hedde PN, Gratton E, Parks J, Tontonoz P. LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling. Elife. 4: e08009. PMID 26173179 DOI: 10.7554/Elife.08009 |
0.692 |
|
| 2015 |
Lee SD, Tontonoz P. Liver X receptors at the intersection of lipid metabolism and atherogenesis. Atherosclerosis. 242: 29-36. PMID 26164157 DOI: 10.1016/J.Atherosclerosis.2015.06.042 |
0.537 |
|
| 2015 |
Rong X, Wang B, Dunham MM, Hedde PN, Wong JS, Gratton E, Young SG, Ford DA, Tontonoz P. Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. Elife. 4. PMID 25806685 DOI: 10.7554/Elife.06557 |
0.407 |
|
| 2015 |
Parks BW, Sallam T, Mehrabian M, Psychogios N, Hui ST, Norheim F, Castellani LW, Rau CD, Pan C, Phun J, Zhou Z, Yang WP, Neuhaus I, Gargalovic PS, Kirchgessner TG, ... ... Tontonoz P, et al. Genetic architecture of insulin resistance in the mouse. Cell Metabolism. 21: 334-46. PMID 25651185 DOI: 10.1016/J.Cmet.2015.01.002 |
0.309 |
|
| 2015 |
Tontonoz P, Cortez-Toledo O, Wroblewski K, Hong C, Lim L, Carranza R, Conneely O, Metzger D, Chao LC. The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice. Molecular and Cellular Biology. 35: 1125-38. PMID 25605333 DOI: 10.1128/Mcb.00715-14 |
0.591 |
|
| 2015 |
Warrier M, Shih DM, Burrows AC, Ferguson D, Gromovsky AD, Brown AL, Marshall S, McDaniel A, Schugar RC, Wang Z, Sacks J, Rong X, Vallim TA, Chou J, Ivanova PT, ... ... Tontonoz P, et al. The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance. Cell Reports. PMID 25600868 DOI: 10.1016/J.Celrep.2014.12.036 |
0.472 |
|
| 2015 |
Drew BG, Hamidi H, Zhou Z, Villanueva CJ, Krum SA, Calkin AC, Parks BW, Ribas V, Kalajian NY, Phun J, Daraei P, Christofk HR, Hewitt SC, Korach KS, Tontonoz P, et al. Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression. The Journal of Biological Chemistry. 290: 5566-81. PMID 25468909 DOI: 10.1074/Jbc.M114.606459 |
0.417 |
|
| 2015 |
Ito A, Hong C, Rong X, Zhu X, Tarling EJ, Hedde PN, Gratton E, Parks J, Tontonoz P. Author response: LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling Elife. DOI: 10.7554/Elife.08009.023 |
0.612 |
|
| 2015 |
Badeau RM, Honka M, Immonen H, Hannukainen J, Soininen P, Kangas A, Ala-Korpela M, Tontonoz P, Nuutila P. VLDL and HDL associates with hepatic glucose uptake, production, and the liver X receptor and its targets in morbidly obese before and after rapid weight-loss interventions Atherosclerosis. 241. DOI: 10.1016/J.Atherosclerosis.2015.04.370 |
0.353 |
|
| 2014 |
Hong C, Marshall SM, McDaniel AL, Graham M, Layne JD, Cai L, Scotti E, Boyadjian R, Kim J, Chamberlain BT, Tangirala RK, Jung ME, Fong L, Lee R, Young SG, ... ... Tontonoz P, et al. The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice. Cell Metabolism. 20: 910-8. PMID 25440061 DOI: 10.1016/J.Cmet.2014.10.001 |
0.637 |
|
| 2014 |
Ma F, Liu SY, Razani B, Arora N, Li B, Kagechika H, Tontonoz P, Núñez V, Ricote M, Cheng G. Retinoid X receptor α attenuates host antiviral response by suppressing type I interferon. Nature Communications. 5: 5494. PMID 25417649 DOI: 10.1038/Ncomms6494 |
0.419 |
|
| 2014 |
Priest C, Tontonoz P. SUMOylation places LRH-1 in PROXimity to lipid metabolism. Cell Metabolism. 20: 558-9. PMID 25295783 DOI: 10.1016/J.Cmet.2014.09.008 |
0.412 |
|
| 2014 |
Chung S, Cuffe H, Marshall SM, McDaniel AL, Ha JH, Kavanagh K, Hong C, Tontonoz P, Temel RE, Parks JS. Dietary cholesterol promotes adipocyte hypertrophy and adipose tissue inflammation in visceral, but not in subcutaneous, fat in monkeys. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 1880-7. PMID 24969772 DOI: 10.1161/Atvbaha.114.303896 |
0.603 |
|
| 2014 |
Calkin AC, Lee SD, Kim J, Van Stijn CM, Wu XH, Lusis AJ, Hong C, Tangirala RI, Tontonoz P. Transgenic expression of dominant-active IDOL in liver causes diet-induced hypercholesterolemia and atherosclerosis in mice. Circulation Research. 115: 442-9. PMID 24935961 DOI: 10.1161/Circresaha.115.304440 |
0.668 |
|
| 2014 |
Lee SD, Tontonoz P. Eosinophils in fat: pink is the new brown. Cell. 157: 1249-50. PMID 24906141 DOI: 10.1016/J.Cell.2014.05.025 |
0.323 |
|
| 2014 |
Hong C, Tontonoz P. Liver X receptors in lipid metabolism: opportunities for drug discovery. Nature Reviews. Drug Discovery. 13: 433-44. PMID 24833295 DOI: 10.1038/Nrd4280 |
0.69 |
|
| 2014 |
Goulbourne CN, Gin P, Tatar A, Nobumori C, Hoenger A, Jiang H, Grovenor CR, Adeyo O, Esko JD, Goldberg IJ, Reue K, Tontonoz P, Bensadoun A, Beigneux AP, Young SG, et al. The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries. Cell Metabolism. 19: 849-60. PMID 24726386 DOI: 10.1016/J.Cmet.2014.01.017 |
0.396 |
|
| 2014 |
Tessem JS, Moss LG, Chao LC, Arlotto M, Lu D, Jensen MV, Stephens SB, Tontonoz P, Hohmeier HE, Newgard CB. Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors. Proceedings of the National Academy of Sciences of the United States of America. 111: 5242-7. PMID 24706823 DOI: 10.1073/Pnas.1320953111 |
0.391 |
|
| 2014 |
Sallam T, Ito A, Rong X, Kim J, van Stijn C, Chamberlain BT, Jung ME, Chao LC, Jones M, Gilliland T, Wu X, Su GL, Tangirala RK, Tontonoz P, Hong C. The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis. Journal of Lipid Research. 55: 1120-1130. PMID 24671012 DOI: 10.1194/Jlr.M047548 |
0.689 |
|
| 2014 |
Adeyo O, Allan BB, Barnes RH, Goulbourne CN, Tatar A, Tu Y, Young LC, Weinstein MM, Tontonoz P, Fong LG, Beigneux AP, Young SG. Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice. The Journal of Investigative Dermatology. 134: 1589-98. PMID 24499735 DOI: 10.1038/Jid.2014.19 |
0.375 |
|
| 2014 |
Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M, Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, ... ... Tontonoz P, et al. MafB promotes atherosclerosis by inhibiting foam-cell apoptosis. Nature Communications. 5: 3147. PMID 24445679 DOI: 10.1038/Ncomms4147 |
0.653 |
|
| 2013 |
Rong X, Albert CJ, Hong C, Duerr MA, Chamberlain BT, Tarling EJ, Ito A, Gao J, Wang B, Edwards PA, Jung ME, Ford DA, Tontonoz P. LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metabolism. 18: 685-97. PMID 24206663 DOI: 10.1016/J.Cmet.2013.10.002 |
0.634 |
|
| 2013 |
Fan J, Shimizu Y, Chan J, Wilkinson A, Ito A, Tontonoz P, Dullaghan E, Galea LA, Pfeifer T, Wellington CL. Hormonal modulators of glial ABCA1 and apoE levels. Journal of Lipid Research. 54: 3139-50. PMID 23999864 DOI: 10.1194/Jlr.M042473 |
0.478 |
|
| 2013 |
Beaven SW, Matveyenko A, Wroblewski K, Chao L, Wilpitz D, Hsu TW, Lentz J, Drew B, Hevener AL, Tontonoz P. Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance. Cell Metabolism. 18: 106-17. PMID 23823481 DOI: 10.1016/J.Cmet.2013.04.021 |
0.424 |
|
| 2013 |
A-Gonzalez N, Guillen JA, Gallardo G, Diaz M, de la Rosa JV, Hernandez IH, Casanova-Acebes M, Lopez F, Tabraue C, Beceiro S, Hong C, Lara PC, Andujar M, Arai S, Miyazaki T, ... ... Tontonoz P, et al. The nuclear receptor LXRα controls the functional specialization of splenic macrophages. Nature Immunology. 14: 831-9. PMID 23770640 DOI: 10.1038/Ni.2622 |
0.66 |
|
| 2013 |
Csaki LS, Dwyer JR, Fong LG, Tontonoz P, Young SG, Reue K. Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling. Progress in Lipid Research. 52: 305-16. PMID 23603613 DOI: 10.1016/J.Plipres.2013.04.001 |
0.454 |
|
| 2013 |
Villanueva CJ, Vergnes L, Wang J, Drew BG, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener AL, Reue K, Fong LG, Young SG, ... Tontonoz P, et al. Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Cell Metabolism. 17: 423-35. PMID 23473036 DOI: 10.1016/J.Cmet.2013.01.016 |
0.767 |
|
| 2013 |
Zhang L, Xu M, Scotti E, Chen ZJ, Tontonoz P. Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor Journal of Lipid Research. 54: 1410-1420. PMID 23419260 DOI: 10.1194/Jlr.M035774 |
0.303 |
|
| 2013 |
Scotti E, Calamai M, Goulbourne CN, Zhang L, Hong C, Lin RR, Choi J, Pilch PF, Fong LG, Zou P, Ting AY, Pavone FS, Young SG, Tontonoz P. IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor. Molecular and Cellular Biology. 33: 1503-14. PMID 23382078 DOI: 10.1128/Mcb.01716-12 |
0.644 |
|
| 2013 |
Chao LC, Soto E, Hong C, Ito A, Pei L, Chawla A, Conneely OM, Tangirala RK, Evans RM, Tontonoz P. Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice. Journal of Lipid Research. 54: 806-15. PMID 23288947 DOI: 10.1194/Jlr.M034157 |
0.684 |
|
| 2013 |
Halperin DS, Pan C, Lusis AJ, Tontonoz P. Vestigial-like 3 is an inhibitor of adipocyte differentiation. Journal of Lipid Research. 54: 473-81. PMID 23152581 DOI: 10.1194/Jlr.M032755 |
0.709 |
|
| 2012 |
Chao LC, Wroblewski K, Ilkayeva OR, Stevens RD, Bain J, Meyer GA, Schenk S, Martinez L, Vergnes L, Narkar VA, Drew BG, Hong C, Boyadjian R, Hevener AL, Evans RM, ... ... Tontonoz P, et al. Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization. Journal of Lipid Research. 53: 2610-9. PMID 23028113 DOI: 10.1194/Jlr.M029355 |
0.589 |
|
| 2012 |
Zhang L, Reue K, Fong LG, Young SG, Tontonoz P. Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 2541-6. PMID 22936343 DOI: 10.1161/Atvbaha.112.250571 |
0.506 |
|
| 2012 |
Chen X, McClusky R, Chen J, Beaven SW, Tontonoz P, Arnold AP, Reue K. The number of x chromosomes causes sex differences in adiposity in mice. Plos Genetics. 8: e1002709. PMID 22589744 DOI: 10.1371/Journal.Pgen.1002709 |
0.306 |
|
| 2012 |
Hong C, Bradley MN, Rong X, Wang X, Wagner A, Grijalva V, Castellani LW, Salazar J, Realegeno S, Boyadjian R, Fogelman AM, Van Lenten BJ, Reddy ST, Lusis AJ, Tangirala RK, ... Tontonoz P, et al. LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice Journal of Lipid Research. 53: 1126-1133. PMID 22454476 DOI: 10.1194/Jlr.M022061 |
0.671 |
|
| 2012 |
Calkin AC, Tontonoz P. Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR Nature Reviews Molecular Cell Biology. 13: 213-224. PMID 22414897 DOI: 10.1038/Nrm3312 |
0.48 |
|
| 2012 |
Chao LC, Tontonoz P. SIRT1 regulation-it ain't all NAD. Molecular Cell. 45: 9-11. PMID 22244328 DOI: 10.1016/J.Molcel.2011.12.017 |
0.307 |
|
| 2012 |
Weinstein MM, Goulbourne CN, Davies BS, Tu Y, Barnes RH, Watkins SM, Davis R, Reue K, Tontonoz P, Beigneux AP, Fong LG, Young SG. Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 230-5. PMID 22173228 DOI: 10.1161/Atvbaha.111.241406 |
0.459 |
|
| 2012 |
Hong C, Kidani Y, A-Gonzalez N, Phung T, Ito A, Rong X, Ericson K, Mikkola H, Beaven SW, Miller LS, Shao WH, Cohen PL, Castrillo A, Tontonoz P, Bensinger SJ. Coordinate regulation of neutrophil homeostasis by liver X receptors in mice. The Journal of Clinical Investigation. 122: 337-47. PMID 22156197 DOI: 10.1172/Jci58393 |
0.669 |
|
| 2011 |
Calkin AC, Goult BT, Zhang L, Fairall L, Hong C, Schwabe JW, Tontonoz P. FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors. Proceedings of the National Academy of Sciences of the United States of America. 108: 20107-12. PMID 22109552 DOI: 10.1073/Pnas.1111589108 |
0.644 |
|
| 2011 |
Guo D, Reinitz F, Youssef M, Hong C, Nathanson D, Akhavan D, Kuga D, Amzajerdi AN, Soto H, Zhu S, Babic I, Tanaka K, Dang J, Iwanami A, Gini B, ... ... Tontonoz P, et al. An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway. Cancer Discovery. 1: 442-56. PMID 22059152 DOI: 10.1158/2159-8290.Cd-11-0102 |
0.624 |
|
| 2011 |
Tontonoz P. Transcriptional and Posttranscriptional Control of Cholesterol Homeostasis by Liver X Receptors Cold Spring Harbor Symposia On Quantitative Biology. 76: 129-137. PMID 21859674 DOI: 10.1101/Sqb.2011.76.010702 |
0.546 |
|
| 2011 |
Young SG, Davies BS, Voss CV, Gin P, Weinstein MM, Tontonoz P, Reue K, Bensadoun A, Fong LG, Beigneux AP. GPIHBP1, an endothelial cell transporter for lipoprotein lipase. Journal of Lipid Research. 52: 1869-84. PMID 21844202 DOI: 10.1194/Jlr.R018689 |
0.35 |
|
| 2011 |
Weissglas-Volkov D, Calkin AC, Tusie-Luna T, Sinsheimer JS, Zelcer N, Riba L, Tino AM, Ordoñez-Sánchez ML, Cruz-Bautista I, Aguilar-Salinas CA, Tontonoz P, Pajukanta P. The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans. The Journal of Clinical Investigation. 121: 3062-71. PMID 21765216 DOI: 10.1172/Jci45504 |
0.376 |
|
| 2011 |
Zhang L, Fairall L, Goult BT, Calkin AC, Hong C, Millard CJ, Tontonoz P, Schwabe JW. The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. Genes & Development. 25: 1262-74. PMID 21685362 DOI: 10.1101/Gad.2056211 |
0.594 |
|
| 2011 |
Villanueva CJ, Waki H, Godio C, Nielsen R, Chou WL, Vargas L, Wroblewski K, Schmedt C, Chao LC, Boyadjian R, Mandrup S, Hevener A, Saez E, Tontonoz P. TLE3 is a dual-function transcriptional coregulator of adipogenesis. Cell Metabolism. 13: 413-27. PMID 21459326 DOI: 10.1016/J.Cmet.2011.02.014 |
0.703 |
|
| 2011 |
Scotti E, Hong C, Yoshinaga Y, Tu Y, Hu Y, Zelcer N, Boyadjian R, de Jong PJ, Young SG, Fong LG, Tontonoz P. Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists. Molecular and Cellular Biology. 31: 1885-93. PMID 21343340 DOI: 10.1128/Mcb.01469-10 |
0.689 |
|
| 2011 |
Hong C, Walczak R, Dhamko H, Bradley MN, Marathe C, Boyadjian R, Salazar JV, Tontonoz P. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. Journal of Lipid Research. 52: 531-9. PMID 21187453 DOI: 10.1194/Jlr.M010686 |
0.848 |
|
| 2011 |
Beaven SW, Wroblewski K, Wang J, Hong C, Bensinger S, Tsukamoto H, Tontonoz P. Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease. Gastroenterology. 140: 1052-62. PMID 21134374 DOI: 10.1053/J.Gastro.2010.11.053 |
0.656 |
|
| 2010 |
Bruhn KW, Marathe C, Maretti-Mira AC, Nguyen H, Haskell J, Tran TA, Vanchinathan V, Gaur U, Wilson ME, Tontonoz P, Craft N. LXR deficiency confers increased protection against visceral Leishmania infection in mice. Plos Neglected Tropical Diseases. 4: e886. PMID 21103366 DOI: 10.1371/Journal.Pntd.0000886 |
0.825 |
|
| 2010 |
Villanueva CJ, Tontonoz P. Licensing PPARγ to Work in Macrophages Immunity. 33: 647-649. PMID 21094459 DOI: 10.1016/J.Immuni.2010.11.017 |
0.436 |
|
| 2010 |
Feig JE, Pineda-Torra I, Sanson M, Bradley MN, Vengrenyuk Y, Bogunovic D, Gautier EL, Rubinstein D, Hong C, Liu J, Wu C, van Rooijen N, Bhardwaj N, Garabedian M, Tontonoz P, et al. LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression. The Journal of Clinical Investigation. 120: 4415-24. PMID 21041949 DOI: 10.1172/Jci38911 |
0.621 |
|
| 2010 |
Calkin AC, Tontonoz P. Genome-Wide Association Studies Identify New Targets in Cardiovascular Disease Science Translational Medicine. 2. PMID 20826839 DOI: 10.1126/Scitranslmed.3001557 |
0.338 |
|
| 2010 |
Weinstein MM, Tu Y, Beigneux AP, Davies BS, Gin P, Voss C, Walzem RL, Reue K, Tontonoz P, Bensadoun A, Fong LG, Young SG. Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 2106-13. PMID 20814015 DOI: 10.1161/Atvbaha.110.214403 |
0.337 |
|
| 2010 |
Calkin AC, Tontonoz P. Liver X Receptor Signaling Pathways and Atherosclerosis Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 1513-1518. PMID 20631351 DOI: 10.1161/Atvbaha.109.191197 |
0.559 |
|
| 2010 |
Park KW, Waki H, Choi SP, Park KM, Tontonoz P. The small molecule phenamil is a modulator of adipocyte differentiation and PPARgamma expression. Journal of Lipid Research. 51: 2775-84. PMID 20519739 DOI: 10.1194/Jlr.M008490 |
0.449 |
|
| 2010 |
Hong C, Duit S, Jalonen P, Out R, Scheer L, Sorrentino V, Boyadjian R, Rodenburg KW, Foley E, Korhonen L, Lindholm D, Nimpf J, van Berkel TJ, Tontonoz P, Zelcer N. The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2. The Journal of Biological Chemistry. 285: 19720-6. PMID 20427281 DOI: 10.1074/Jbc.M110.123729 |
0.699 |
|
| 2010 |
Scotti E, Tontonoz P. Peroxisome Proliferator-Activated Receptor γ Dances with Different Partners in Macrophage and Adipocytes Molecular and Cellular Biology. 30: 2076-2077. PMID 20176804 DOI: 10.1128/Mcb.00171-10 |
0.497 |
|
| 2009 |
Chao LC, Wroblewski K, Zhang Z, Pei L, Vergnes L, Ilkayeva OR, Ding SY, Reue K, Watt MJ, Newgard CB, Pilch PF, Hevener AL, Tontonoz P. Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77. Diabetes. 58: 2788-96. PMID 19741162 DOI: 10.2337/Db09-0763 |
0.412 |
|
| 2009 |
A-Gonzalez N, Bensinger SJ, Hong C, Beceiro S, Bradley MN, Zelcer N, Deniz J, Ramirez C, DÃaz M, Gallardo G, de Galarreta CR, Salazar J, Lopez F, Edwards P, Parks J, ... ... Tontonoz P, et al. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity. 31: 245-58. PMID 19646905 DOI: 10.1016/J.Immuni.2009.06.018 |
0.667 |
|
| 2009 |
Kim WK, Meliton V, Park KW, Hong C, Tontonoz P, Niewiadomski P, Waschek JA, Tetradis S, Parhami F. Negative regulation of Hedgehog signaling by liver X receptors. Molecular Endocrinology (Baltimore, Md.). 23: 1532-43. PMID 19608643 DOI: 10.1210/Me.2008-0453 |
0.673 |
|
| 2009 |
Zelcer N, Hong C, Boyadjian R, Tontonoz P. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science (New York, N.Y.). 325: 100-4. PMID 19520913 DOI: 10.1126/Science.1168974 |
0.677 |
|
| 2009 |
Dean JT, Tran L, Beaven S, Tontonoz P, Reue K, Dipple KM, Liao JC. Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt. Cell Metabolism. 9: 525-36. PMID 19490907 DOI: 10.1016/J.Cmet.2009.04.008 |
0.399 |
|
| 2009 |
Park KW, Waki H, Kim WK, Davies BS, Young SG, Parhami F, Tontonoz P. The small molecule phenamil induces osteoblast differentiation and mineralization. Molecular and Cellular Biology. 29: 3905-14. PMID 19433444 DOI: 10.1128/Mcb.00002-09 |
0.35 |
|
| 2009 |
Bensinger SJ, Tontonoz P. A Nurr1 pathway for neuroprotection. Cell. 137: 26-8. PMID 19345183 DOI: 10.1016/J.Cell.2009.03.024 |
0.352 |
|
| 2009 |
Hsu JJ, Lu J, Huang MS, Geng Y, Sage AP, Bradley MN, Tontonoz P, Demer LL, Tintut Y. T0901317, an LXR agonist, augments PKA-induced vascular cell calcification. Febs Letters. 583: 1344-8. PMID 19327357 DOI: 10.1016/J.Febslet.2009.03.039 |
0.363 |
|
| 2009 |
Marathe C, Bradley MN, Hong C, Chao L, Wilpitz D, Salazar J, Tontonoz P. Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/- bone marrow. Journal of Lipid Research. 50: 214-24. PMID 18772483 DOI: 10.1194/Jlr.M800189-Jlr200 |
0.825 |
|
| 2008 |
Park KW, Halperin DS, Tontonoz P. Before they were fat: adipocyte progenitors. Cell Metabolism. 8: 454-7. PMID 19041761 DOI: 10.1016/J.Cmet.2008.11.001 |
0.652 |
|
| 2008 |
Naiki Y, Sorrentino R, Wong MH, Michelsen KS, Shimada K, Chen S, Yilmaz A, Slepenkin A, Schröder NW, Crother TR, Bulut Y, Doherty TM, Bradley M, Shaposhnik Z, Peterson EM, ... Tontonoz P, et al. TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis. Journal of Immunology (Baltimore, Md. : 1950). 181: 7176-85. PMID 18981139 DOI: 10.4049/Jimmunol.181.10.7176 |
0.395 |
|
| 2008 |
Chao LC, Bensinger SJ, Villanueva CJ, Wroblewski K, Tontonoz P. Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1. Molecular Endocrinology (Baltimore, Md.). 22: 2596-608. PMID 18945812 DOI: 10.1210/Me.2008-0161 |
0.491 |
|
| 2008 |
Davies BS, Waki H, Beigneux AP, Farber E, Weinstein MM, Wilpitz DC, Tai LJ, Evans RM, Fong LG, Tontonoz P, Young SG. The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma. Molecular Endocrinology (Baltimore, Md.). 22: 2496-504. PMID 18787041 DOI: 10.1210/Me.2008-0146 |
0.494 |
|
| 2008 |
Hong C, Tontonoz P. Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors. Current Opinion in Genetics & Development. 18: 461-7. PMID 18782619 DOI: 10.1016/J.Gde.2008.07.016 |
0.71 |
|
| 2008 |
Hummasti S, Hong C, Bensinger SJ, Tontonoz P. HRASLS3 is a PPARgamma-selective target gene that promotes adipocyte differentiation. Journal of Lipid Research. 49: 2535-44. PMID 18664718 DOI: 10.1194/Jlr.M800269-Jlr200 |
0.831 |
|
| 2008 |
Bensinger SJ, Tontonoz P. Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature. 454: 470-7. PMID 18650918 DOI: 10.1038/Nature07202 |
0.512 |
|
| 2008 |
Bensinger SJ, Bradley MN, Joseph SB, Zelcer N, Janssen EM, Hausner MA, Shih R, Parks JS, Edwards PA, Jamieson BD, Tontonoz P. LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell. 134: 97-111. PMID 18614014 DOI: 10.1016/J.Cell.2008.04.052 |
0.696 |
|
| 2008 |
Park KW, Waki H, Villanueva CJ, Monticelli LA, Hong C, Kang S, MacDougald OA, Goldrath AW, Tontonoz P. Inhibitor of DNA binding 2 is a small molecule-inducible modulator of peroxisome proliferator-activated receptor-gamma expression and adipocyte differentiation. Molecular Endocrinology (Baltimore, Md.). 22: 2038-48. PMID 18562627 DOI: 10.1210/Me.2007-0454 |
0.681 |
|
| 2008 |
Jiang Q, Lee CY, Mandrekar S, Wilkinson B, Cramer P, Zelcer N, Mann K, Lamb B, Willson TM, Collins JL, Richardson JC, Smith JD, Comery TA, Riddell D, Holtzman DM, ... Tontonoz P, et al. ApoE promotes the proteolytic degradation of Abeta. Neuron. 58: 681-93. PMID 18549781 DOI: 10.1016/J.Neuron.2008.04.010 |
0.332 |
|
| 2008 |
Tontonoz P, Spiegelman BM. Fat and beyond: the diverse biology of PPARgamma. Annual Review of Biochemistry. 77: 289-312. PMID 18518822 DOI: 10.1146/Annurev.Biochem.77.061307.091829 |
0.657 |
|
| 2008 |
Gallardo-Soler A, Gómez-Nieto C, Campo ML, Marathe C, Tontonoz P, Castrillo A, Corraliza I. Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity. Molecular Endocrinology (Baltimore, Md.). 22: 1394-402. PMID 18323470 DOI: 10.1210/Me.2007-0525 |
0.832 |
|
| 2008 |
Hummasti S, Tontonoz P. Adopting New Orphans into the Family of Metabolic Regulators Molecular Endocrinology. 22: 1743-1753. PMID 18258684 DOI: 10.1210/Me.2007-0566 |
0.808 |
|
| 2007 |
Waki H, Tontonoz P. Endocrine Functions of Adipose Tissue Annual Review of Pathology-Mechanisms of Disease. 2: 31-56. PMID 18039092 DOI: 10.1146/Annurev.Pathol.2.010506.091859 |
0.359 |
|
| 2007 |
Molteni V, Li X, Nabakka J, Liang F, Wityak J, Koder A, Vargas L, Romeo R, Mitro N, Mak PA, Seidel HM, Haslam JA, Chow D, Tuntland T, Spalding TA, ... ... Tontonoz P, et al. N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta. Journal of Medicinal Chemistry. 50: 4255-9. PMID 17665897 DOI: 10.1021/Jm070453F |
0.699 |
|
| 2007 |
Bradley MN, Hong C, Chen M, Joseph SB, Wilpitz DC, Wang X, Lusis AJ, Collins A, Hseuh WA, Collins JL, Tangirala RK, Tontonoz P. Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. The Journal of Clinical Investigation. 117: 2337-46. PMID 17657314 DOI: 10.1172/Jci31909 |
0.778 |
|
| 2007 |
Zelcer N, Khanlou N, Clare R, Jiang Q, Reed-Geaghan EG, Landreth GE, Vinters HV, Tontonoz P. Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors. Proceedings of the National Academy of Sciences of the United States of America. 104: 10601-6. PMID 17563384 DOI: 10.1073/Pnas.0701096104 |
0.464 |
|
| 2007 |
Chao LC, Zhang Z, Pei L, Saito T, Tontonoz P, Pilch PF. Nur77 coordinately regulates expression of genes linked to glucose metabolism in skeletal muscle. Molecular Endocrinology (Baltimore, Md.). 21: 2152-63. PMID 17550977 DOI: 10.1210/Me.2007-0169 |
0.38 |
|
| 2007 |
Waki H, Park KW, Mitro N, Pei L, Damoiseaux R, Wilpitz DC, Reue K, Saez E, Tontonoz P. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression. Cell Metabolism. 5: 357-70. PMID 17488638 DOI: 10.1016/J.Cmet.2007.03.010 |
0.713 |
|
| 2007 |
Waki H, Tontonoz P. STAMPing out Inflammation Cell. 129: 451-452. PMID 17482536 DOI: 10.1016/J.Cell.2007.04.022 |
0.306 |
|
| 2007 |
Cao F, Castrillo A, Tontonoz P, Re F, Byrne GI. Chlamydia pneumoniae--induced macrophage foam cell formation is mediated by Toll-like receptor 2. Infection and Immunity. 75: 753-9. PMID 17145941 DOI: 10.1128/Iai.01386-06 |
0.402 |
|
| 2007 |
Marathe C, Tontonoz P. Linking metabolism to immunity through PPARγ Blood. 110: 3092-3093. DOI: 10.1182/Blood-2007-08-105478 |
0.817 |
|
| 2006 |
Blaschke F, Takata Y, Caglayan E, Collins A, Tontonoz P, Hsueh WA, Tangirala RK. A nuclear receptor corepressor-dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor. Circulation Research. 99: e88-99. PMID 17110595 DOI: 10.1161/01.Res.0000252878.34269.06 |
0.519 |
|
| 2006 |
Chow EK, Castrillo A, Shahangian A, Pei L, O'Connell RM, Modlin RL, Tontonoz P, Cheng G. A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections. The Journal of Experimental Medicine. 203: 2589-602. PMID 17074929 DOI: 10.1084/Jem.20060929 |
0.413 |
|
| 2006 |
Marathe C, Bradley MN, Hong C, Lopez F, Ruiz de Galarreta CM, Tontonoz P, Castrillo A. The arginase II gene is an anti-inflammatory target of liver X receptor in macrophages. The Journal of Biological Chemistry. 281: 32197-206. PMID 16943198 DOI: 10.1074/Jbc.M605237200 |
0.833 |
|
| 2006 |
Pei L, Waki H, Vaitheesvaran B, Wilpitz DC, Kurland IJ, Tontonoz P. NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism. Nature Medicine. 12: 1048-55. PMID 16906154 DOI: 10.1038/Nm1471 |
0.438 |
|
| 2006 |
Chen M, Bradley MN, Beaven SW, Tontonoz P. Phosphorylation of the liver X receptors. Febs Letters. 580: 4835-41. PMID 16904112 DOI: 10.1016/J.Febslet.2006.07.074 |
0.448 |
|
| 2006 |
Baldán A, Pei L, Lee R, Tarr P, Tangirala RK, Weinstein MM, Frank J, Li AC, Tontonoz P, Edwards PA. Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 2301-7. PMID 16888235 DOI: 10.1161/01.Atv.0000240051.22944.Dc |
0.383 |
|
| 2006 |
Hummasti S, Tontonoz P. The peroxisome proliferator-activated receptor N-terminal domain controls isotype-selective gene expression and adipogenesis. Molecular Endocrinology. 20: 1261-1275. PMID 16556736 DOI: 10.1210/Me.2006-0025 |
0.832 |
|
| 2006 |
Zelcer N, Tontonoz P. Liver X receptors as integrators of metabolic and inflammatory signaling. Journal of Clinical Investigation. 116: 607-614. PMID 16511593 DOI: 10.1172/Jci27883 |
0.548 |
|
| 2006 |
Beaven SW, Tontonoz P. Nuclear Receptors in Lipid Metabolism: Targeting the Heart of Dyslipidemia Annual Review of Medicine. 57: 313-329. PMID 16409152 DOI: 10.1146/Annurev.Med.57.121304.131428 |
0.498 |
|
| 2006 |
Pei L, Castrillo A, Tontonoz P. Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77. Molecular Endocrinology (Baltimore, Md.). 20: 786-94. PMID 16339277 DOI: 10.1210/Me.2005-0331 |
0.526 |
|
| 2005 |
Zelcer N, Tontonoz P. SUMOylation and PPARγ: Wrestling with inflammatory signaling Cell Metabolism. 2: 273-275. PMID 16271524 DOI: 10.1016/J.Cmet.2005.10.004 |
0.392 |
|
| 2005 |
Chen M, Beaven S, Tontonoz P. Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha. Journal of Lipid Research. 46: 2570-2579. PMID 16170053 DOI: 10.1194/Jlr.M500157-Jlr200 |
0.502 |
|
| 2005 |
Arai S, Shelton JM, Chen M, Bradley MN, Castrillo A, Bookout AL, Mak PA, Edwards PA, Mangelsdorf DJ, Tontonoz P, Miyazaki T. A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Cell Metabolism. 1: 201-13. PMID 16054063 DOI: 10.1016/J.Cmet.2005.02.002 |
0.351 |
|
| 2005 |
Pei L, Castrillo A, Chen M, Hoffmann A, Tontonoz P. Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli. The Journal of Biological Chemistry. 280: 29256-62. PMID 15964844 DOI: 10.1074/Jbc.M502606200 |
0.514 |
|
| 2005 |
Lin J, Yang R, Tarr PT, Wu PH, Handschin C, Li S, Yang W, Pei L, Uldry M, Tontonoz P, Newgard CB, Spiegelman BM. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell. 120: 261-73. PMID 15680331 DOI: 10.1016/J.Cell.2004.11.043 |
0.738 |
|
| 2005 |
Bradley MN, Tontonoz P. Lesion macrophages are a key target for the antiatherogenic effects of LXR agonists. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 10-1. PMID 15626767 DOI: 10.1161/01.Atv.0000152727.69018.61 |
0.556 |
|
| 2005 |
Sheth SS, Castellani LW, Chari S, Wagg C, Thipphavong CK, Bodnar JS, Tontonoz P, Attie AD, Lopaschuk GD, Lusis AJ. Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition. Journal of Lipid Research. 46: 123-34. PMID 15520447 DOI: 10.1194/Jlr.M400341-Jlr200 |
0.408 |
|
| 2005 |
Bradley MN, Tontonoz P. LXR: A nuclear receptor target for cardiovascular disease? Drug Discovery Today: Therapeutic Strategies. 2: 97-103. DOI: 10.1016/J.Ddstr.2005.05.018 |
0.515 |
|
| 2004 |
Castrillo A, Tontonoz P. PPARs in atherosclerosis: the clot thickens Journal of Clinical Investigation. 114: 1538-1540. PMID 15578084 DOI: 10.1172/Jci23705 |
0.336 |
|
| 2004 |
Joseph SB, Bradley MN, Castrillo A, Bruhn KW, Mak PA, Pei L, Hogenesch J, O'connell RM, Cheng G, Saez E, Miller JF, Tontonoz P. LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell. 119: 299-309. PMID 15479645 DOI: 10.1016/J.Cell.2004.09.032 |
0.821 |
|
| 2004 |
Castrillo A, Tontonoz P. NUCLEAR RECEPTORS IN MACROPHAGE BIOLOGY: At the Crossroads of Lipid Metabolism and Inflammation Annual Review of Cell and Developmental Biology. 20: 455-480. PMID 15473848 DOI: 10.1146/Annurev.Cellbio.20.012103.134432 |
0.549 |
|
| 2004 |
Hummasti S, Laffitte BA, Watson MA, Galardi C, Chao LC, Ramamurthy L, Moore JT, Tontonoz P. Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target. Journal of Lipid Research. 45: 616-25. PMID 14703507 DOI: 10.1194/Jlr.M300312-Jlr200 |
0.846 |
|
| 2004 |
Walczak R, Joseph SB, Laffitte BA, Castrillo A, Pei L, Tontonoz P. Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors. The Journal of Biological Chemistry. 279: 9905-11. PMID 14699103 DOI: 10.1074/Jbc.M310587200 |
0.679 |
|
| 2003 |
Castrillo A, Joseph SB, Vaidya SA, Haberland M, Fogelman AM, Cheng G, Tontonoz P. Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism. Molecular Cell. 12: 805-16. PMID 14580333 DOI: 10.1016/S1097-2765(03)00384-8 |
0.73 |
|
| 2003 |
Laffitte BA, Chao LC, Li J, Walczak R, Hummasti S, Joseph SB, Castrillo A, Wilpitz DC, Mangelsdorf DJ, Collins JL, Saez E, Tontonoz P. Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proceedings of the National Academy of Sciences of the United States of America. 100: 5419-24. PMID 12697904 DOI: 10.1073/Pnas.0830671100 |
0.809 |
|
| 2003 |
Tontonoz P, Mangelsdorf DJ. Liver X Receptor Signaling Pathways in Cardiovascular Disease Molecular Endocrinology. 17: 985-993. PMID 12690094 DOI: 10.1210/Me.2003-0061 |
0.52 |
|
| 2003 |
Joseph SB, Tontonoz P. LXRs: new therapeutic targets in atherosclerosis? Current Opinion in Pharmacology. 3: 192-7. PMID 12681243 DOI: 10.1016/S1471-4892(03)00009-2 |
0.729 |
|
| 2003 |
Laffitte BA, Joseph SB, Chen M, Castrillo A, Repa J, Wilpitz D, Mangelsdorf D, Tontonoz P. The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions. Molecular and Cellular Biology. 23: 2182-91. PMID 12612088 DOI: 10.1128/Mcb.23.6.2182-2191.2003 |
0.753 |
|
| 2003 |
Castrillo A, Joseph SB, Marathe C, Mangelsdorf DJ, Tontonoz P. Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages. The Journal of Biological Chemistry. 278: 10443-9. PMID 12531895 DOI: 10.1074/Jbc.M213071200 |
0.794 |
|
| 2003 |
Joseph SB, Castrillo A, Laffitte BA, Mangelsdorf DJ, Tontonoz P. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nature Medicine. 9: 213-9. PMID 12524534 DOI: 10.1038/nm820 |
0.718 |
|
| 2002 |
Tangirala RK, Bischoff ED, Joseph SB, Wagner BL, Walczak R, Laffitte BA, Daige CL, Thomas D, Heyman RA, Mangelsdorf DJ, Wang X, Lusis AJ, Tontonoz P, Schulman IG. Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America. 99: 11896-901. PMID 12193651 DOI: 10.1073/Pnas.182199799 |
0.731 |
|
| 2002 |
Xu J, Xiao G, Trujillo C, Chang V, Blanco L, Joseph SB, Bassilian S, Saad MF, Tontonoz P, Lee WN, Kurland IJ. Peroxisome proliferator-activated receptor alpha (PPARalpha) influences substrate utilization for hepatic glucose production. The Journal of Biological Chemistry. 277: 50237-44. PMID 12176975 DOI: 10.1074/Jbc.M201208200 |
0.636 |
|
| 2002 |
Joseph SB, McKilligin E, Pei L, Watson MA, Collins AR, Laffitte BA, Chen M, Noh G, Goodman J, Hagger GN, Tran J, Tippin TK, Wang X, Lusis AJ, Hsueh WA, ... ... Tontonoz P, et al. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 7604-9. PMID 12032330 DOI: 10.1073/Pnas.112059299 |
0.716 |
|
| 2002 |
Mak PA, Laffitte BA, Desrumaux C, Joseph SB, Curtiss LK, Mangelsdorf DJ, Tontonoz P, Edwards PA. Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta. The Journal of Biological Chemistry. 277: 31900-8. PMID 12032151 DOI: 10.1074/Jbc.M202993200 |
0.699 |
|
| 2002 |
Laffitte BA, Tontonoz P. Orphan nuclear receptors find a home in the arterial wall. Current Atherosclerosis Reports. 4: 213-21. PMID 11931719 DOI: 10.1007/S11883-002-0022-6 |
0.519 |
|
| 2002 |
Walczak R, Tontonoz P. PPARadigms and PPARadoxes: expanding roles for PPARgamma in the control of lipid metabolism. Journal of Lipid Research. 43: 177-86. PMID 11861659 |
0.389 |
|
| 2002 |
Joseph SB, Laffitte BA, Patel PH, Watson MA, Matsukuma KE, Walczak R, Collins JL, Osborne TF, Tontonoz P. Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. The Journal of Biological Chemistry. 277: 11019-25. PMID 11790787 DOI: 10.1074/Jbc.M111041200 |
0.727 |
|
| 2002 |
Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. The Journal of Biological Chemistry. 277: 2908-15. PMID 11706036 DOI: 10.1074/Jbc.M109326200 |
0.482 |
|
| 2001 |
Laffitte BA, Joseph SB, Walczak R, Pei L, Wilpitz DC, Collins JL, Tontonoz P. Autoregulation of the human liver X receptor alpha promoter. Molecular and Cellular Biology. 21: 7558-68. PMID 11604492 DOI: 10.1128/Mcb.21.22.7558-7568.2001 |
0.7 |
|
| 2001 |
Singh Ahuja H, Liu S, Crombie DL, Boehm M, Leibowitz MD, Heyman RA, Depre C, Nagy L, Tontonoz P, Davies PJ. Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents. Molecular Pharmacology. 59: 765-73. PMID 11259621 DOI: 10.1124/Mol.59.4.765 |
0.405 |
|
| 2001 |
Chawla A, Boisvert WA, Lee CH, Laffitte BA, Barak Y, Joseph SB, Liao D, Nagy L, Edwards PA, Curtiss LK, Evans RM, Tontonoz P. A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Molecular Cell. 7: 161-71. PMID 11172721 DOI: 10.1016/S1097-2765(01)00164-2 |
0.704 |
|
| 2001 |
Chawla A, Barak Y, Nagy L, Liao D, Tontonoz P, Evans RM. PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nature Medicine. 7: 48-52. PMID 11135615 DOI: 10.1038/83336 |
0.511 |
|
| 2001 |
Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR, Mangelsdorf DJ, Tontonoz P. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes Proceedings of the National Academy of Sciences of the United States of America. 98: 507-512. DOI: 10.1073/Pnas.98.2.507 |
0.735 |
|
| 2000 |
Venkateswaran A, Laffitte BA, Joseph SB, Mak PA, Wilpitz DC, Edwards PA, Tontonoz P. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. Proceedings of the National Academy of Sciences of the United States of America. 97: 12097-102. PMID 11035776 DOI: 10.1073/Pnas.200367697 |
0.722 |
|
| 2000 |
Lee H, Shi W, Tontonoz P, Wang S, Subbanagounder G, Hedrick CC, Hama S, Borromeo C, Evans RM, Berliner JA, Nagy L. Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells. Circulation Research. 87: 516-21. PMID 10988245 DOI: 10.1161/01.Res.87.6.516 |
0.439 |
|
| 1999 |
Tontonoz P, Nagy L. Regulation of macrophage gene expression by peroxisome-proliferator-activated receptor y: implications for cardiovascular disease Current Opinion in Lipidology. 10: 485-490. PMID 10680041 DOI: 10.1097/00041433-199912000-00002 |
0.511 |
|
| 1999 |
Devine JH, Eubank DW, Clouthier DE, Tontonoz P, Spiegelman BM, Hammer RE, Beale EG. Adipose expression of the phosphoenolpyruvate carboxykinase promoter requires peroxisome proliferator-activated receptor gamma and 9-cis-retinoic acid receptor binding to an adipocyte-specific enhancer in vivo. The Journal of Biological Chemistry. 274: 13604-12. PMID 10224131 DOI: 10.1074/Jbc.274.19.13604 |
0.605 |
|
| 1998 |
Saez E, Tontonoz P, Nelson MC, Alvarez JG, Ming UT, Baird SM, Thomazy VA, Evans RM. Activators of the nuclear receptor PPARgamma enhance colon polyp formation. Nature Medicine. 4: 1058-61. PMID 9734400 DOI: 10.1038/2042 |
0.717 |
|
| 1998 |
Mueller E, Sarraf P, Tontonoz P, Evans RM, Martin KJ, Zhang M, Fletcher C, Singer S, Spiegelman BM. Terminal differentiation of human breast cancer through PPAR gamma. Molecular Cell. 1: 465-70. PMID 9660931 DOI: 10.1016/S1097-2765(00)80047-7 |
0.535 |
|
| 1998 |
Tontonoz P, Nagy L, Alvarez JG, Thomazy VA, Evans RM. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell. 93: 241-52. PMID 9568716 DOI: 10.1016/S0092-8674(00)81575-5 |
0.539 |
|
| 1998 |
Nagy L, Tontonoz P, Alvarez JG, Chen H, Evans RM. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell. 93: 229-40. PMID 9568715 DOI: 10.1016/S0092-8674(00)81574-3 |
0.5 |
|
| 1997 |
Hollenberg AN, Susulic VS, Madura JP, Zhang B, Moller DE, Tontonoz P, Sarraf P, Spiegelman BM, Lowell BB. Functional antagonism between CCAAT/enhancer binding protein-α and peroxisome proliferator-activated receptor-γ on the leptin promoter Journal of Biological Chemistry. 272: 5283-5290. PMID 9030601 DOI: 10.1074/Jbc.272.8.5283 |
0.602 |
|
| 1997 |
Tontonoz P, Singer S, Forman BM, Sarraf P, Fletcher JA, Fletcher CD, Brun RP, Mueller E, Altiok S, Oppenheim H, Evans RM, Spiegelman BM. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor. Proceedings of the National Academy of Sciences of the United States of America. 94: 237-41. PMID 8990192 DOI: 10.1073/Pnas.94.1.237 |
0.606 |
|
| 1996 |
Tontonoz P, Hu E, Spiegelman BM. Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor gamma. Current Opinion in Genetics & Development. 5: 571-6. PMID 8664544 DOI: 10.1016/0959-437X(95)80025-5 |
0.682 |
|
| 1996 |
Brun RP, Tontonoz P, Forman BM, Ellis R, Chen J, Evans RM, Spiegelman BM. Differential activation of adipogenesis by multiple PPAR isoforms. Genes & Development. 10: 974-84. PMID 8608944 DOI: 10.1101/Gad.10.8.974 |
0.646 |
|
| 1996 |
Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell. 83: 803-12. PMID 8521497 DOI: 10.1016/0092-8674(95)90193-0 |
0.63 |
|
| 1995 |
Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell. 79: 1147-56. PMID 8001151 DOI: 10.1016/0092-8674(94)90006-X |
0.641 |
|
| 1995 |
Tontonoz P, Graves RA, Budavari AI, Erdjument-Bromage H, Lui M, Hu E, Tempst P, Spiegelman BM. Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha. Nucleic Acids Research. 22: 5628-34. PMID 7838715 DOI: 10.1093/Nar/22.25.5628 |
0.592 |
|
| 1995 |
Tontonoz P, Hu E, Devine J, Beale EG, Spiegelman BM. PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Molecular and Cellular Biology. 15: 351-7. PMID 7799943 DOI: 10.1128/Mcb.15.1.351 |
0.621 |
|
| 1995 |
Hu E, Tontonoz P, Spiegelman BM. Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha. Proceedings of the National Academy of Sciences of the United States of America. 92: 9856-60. PMID 7568232 DOI: 10.1073/Pnas.92.21.9856 |
0.56 |
|
| 1994 |
Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM. mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes & Development. 8: 1224-34. PMID 7926726 DOI: 10.1101/Gad.8.10.1224 |
0.627 |
|
| 1993 |
Tontonoz P, Kim JB, Graves RA, Spiegelman BM. ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Molecular and Cellular Biology. 13: 4753-9. PMID 8336713 DOI: 10.1128/Mcb.13.8.4753 |
0.678 |
|
| 1992 |
Graves RA, Tontonoz P, Platt KA, Ross SR, Spiegelman BM. Identification of a fat cell enhancer: analysis of requirements for adipose tissue-specific gene expression. Journal of Cellular Biochemistry. 49: 219-24. PMID 1644859 DOI: 10.1002/Jcb.240490303 |
0.593 |
|
| 1992 |
Graves RA, Tontonoz P, Spiegelman BM. Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression. Molecular and Cellular Biology. 12: 1202-8. PMID 1545801 DOI: 10.1128/Mcb.12.3.1202 |
0.598 |
|
| 1991 |
Graves RA, Tontonoz P, Ross SR, Spiegelman BM. Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor. Genes & Development. 5: 428-37. PMID 2001842 DOI: 10.1101/Gad.5.3.428 |
0.589 |
|
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